PROCEDURE FOR PREPARING STREPTOMYCIN SULFATE NANO EMULSION SYSTEM

Abstract

The invention proposes a process for preparing a streptomycin sulfate nanoemulsion system including the following steps: i) preparing the oil phase including vitamin E acetate, Span 20, and Tween 80; ii) adding water to the oil phase of step i) to obtain the dispersed phase; iii) balancing the dispersed phase mixture of step ii) by gentle magnetic stirring; iv) adding streptomycin sulfate to the dispersed phase of step iii) and cutting the resulting crude emulsion; v) high-pressure homogenization of the emulsion of step iv) using a high-pressure homogenizer; and vi) leaving the emulsion of step v) overnight and filtering to obtain the microemulsion system. The process according to the invention allows the creation of a streptomycin sulfate microemulsion system with very small particle sizes, stable with suitable active ingredient content, helping to increase bioavailability.