PROCEDURES FOR THE PREPARATION OF ENZALUTAMIDE, PROCEDURES FOR THE PREPARATION OF FORM I CRYSTALLINE ENZALUTAMIDE, PROCEDURES FOR THE PREPARATION OF AMORPHOUS FORM OF ENZALUTAMIDE AND ALKYL OR BENZYL ESTERS OF [4-CYANO-3-(TRIFLOMETHYL)PHENYL]CARBAMODITHIOIC ACID

Abstract

The invention proposes a novel [4'-cyano-3-(trifluoromethyl)phenyl]carbamodithioic acid, a synthesis process for this acid, and a more economical and efficient HPLC synthesis process for Enzalutamide, resulting in higher purity and reduced impurities. Furthermore, the invention proposes a synthesis process for the crystalline form of Enzalutamide and a synthesis process for the amorphous form of Enzalutamide.