Hydroxylamine nitric oxide donors for thermally induced delivery of inhalable nitric oxide

Thermo-responsive nitric oxide releasing compounds address the limitations of current iNO delivery systems by enabling portable, stable, and safe NO delivery for pulmonary disorders and antimicrobial uses.

WO2026006808A1 Publication Date: 2026-01-02WAYNE STATE UNIV
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Patent Information

Application Number
PCT/US2025/035801
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-28
Filing Date
2025-06-27
Publication Date
2026-01-02

AI Technical Summary

Technical Problem

Current iNO delivery systems are costly, difficult to transport, and dangerous, limiting their use to controlled hospital settings, and alternative on-demand systems face challenges with portability, NO purity, and stability, especially when using toxic and/or explosive NO precursors.

Method used

Development of thermo-responsive nitric oxide releasing compounds based on N-trityl 3,6-dihydro-1,2-oxazines and allyl hydroxylamine, which can be stored for extended periods and released via heat, integrated into portable inhalation devices for controlled NO delivery.

Benefits of technology

Provides portable, stable, and safe delivery of nitric oxide for treating pulmonary disorders and antimicrobial applications with minimal loss of NO delivery activity, maintaining purity and controlled release profiles.

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Abstract

Provided are thermo-responsive nitric oxide (NO) releasing molecules ("donors") and their use with polymer delivery systems. The delivery systems may include devices that allow for delivery of a dose of NO for inhalation such as portable inhalation devices. The compositions and methods may be used in the treatment of pulmonary conditions such as pulmonary hypertension, acute pulmonary vasoconstriction, respiratory distress syndrome, pulmonary edema, sepsis, and asthma. In some aspects, the compositions and methods provide a portable NO delivery mechanism allowing safe and pure NO administration outside of as well as in hospital settings.
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