DESIGNED AFFINITY ANTI-TRANSFERRIN RECEPTOR ANTIBODIES

Abstract

This document discloses an anti-transferrin receptor antibody that binds specifically to the human transferrin receptor and the macaque transferrin receptor, comprising (i) a humanized heavy-chain variable domain derived from the heavy-chain variable domain of SEQ ID No. 01, and (ii) a humanized light-chain variable domain derived from the light-chain variable domain of SEQ ID No. 26, wherein the antibody has a dissociation rate for the human transferrin receptor that is equal to or less than (i.e., at most) the dissociation rate of anti-transferrin receptor antibody 128.1 for the macaque transferrin receptor, wherein the dissociation rates are determined by surface plasmon resonance, and wherein the anti-transferrin receptor antibody 128.1 has a heavy-chain variable domain of SEQ ID No. 64 and a light-chain variable domain of SEQ ID No. 26. No. 65.