GLUCAGON RECEPTOR AGONISTS
AR106325B1Active Publication Date: 2026-08-26ELANCO US INC
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Patent Information
- Application Number
- ARP20160103112
- Authority / Receiving Office
- AR · AR
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2015-10-26
- Filing Date
- 2016-10-12
- Publication Date
- 2026-08-26
- Estimated Expiration
- 2036-10-12
Abstract
Claim 1: A glucagon receptor agonist compound, characterized in that it comprises the formula: YX¹QGTFX²SDYSKYLDX³KKAX⁴EFVX⁵WLLEX⁶X⁷ wherein X¹ is Aib; X² is T; X³ is Aib; X⁴ is K chemically modified by conjugation to the e-amino group of the side chain of K with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)₂-(gGlu)ₐ-CO-(CH₂)ᵇ-CO₂H, wherein a is 1 and b is 18; X⁵ is A; X⁶ is E; and X⁷ is absent; (SEC ID No. 12); or a pharmaceutically acceptable salt thereof. Claim 5: A method for treating fatty liver, characterized in that it comprises administering to a bovine in need thereof, an effective amount of the glucagon receptor agonist according to any one of claims 1-4. Claim 9: A pharmaceutical composition, characterized in that it comprises the glucagon receptor agonist according to any one of claims 1-4 and a pharmaceutically acceptable carrier, diluent, or excipient.
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Claims
1. An isolated glucagon receptor agonist compound, characterized in that it comprises the formula: YX1QGTFX2SDYSKYLDX3KKAX4EFVX5WLLEX6X7 wherein X1 is Aib; X2 is T; X3 is Aib; X4 is K chemically modified by conjugation to the epsilon-amino group of the K side chain with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(γGlu)a-CO-(CH2)b-CO2H, wherein a is 1 and b is 16 or 18; X5 is A; X6 is E; and X7 is absent; (SEC ID NO: 12) or (SEQ ID NO: 11); or a pharmaceutically acceptable salt thereof. Four claims follow.