SULFONYLUREA DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND THEIR USE IN THE TREATMENT OF NLRP3 INFLAMASOME-MEDIATED DISEASES

Abstract

It also relates to salts, solvates, and prodrugs of said compounds, to pharmaceutical compositions of said compounds, and to the use of said compounds in the treatment and prevention of medical disorders and diseases, more particularly by inhibiting NLRP3. Claim 1: A compound of formula (1), wherein: Q is selected from O or S; R¹ is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R¹ is linked to the sulfur atom of the sulfonylurea group by means of a ring carbon atom and wherein R¹ may be optionally substituted; and R² is a cyclic group substituted at the d position wherein R² may be further optionally substituted.

Claims

1. A compound of formula (I): (FORMULA I) or a pharmaceutically acceptable salt thereof; characterized in that: Q is O; R1 is a non-aromatic heterocyclic group selected from: (FORMULAS), wherein R1 is attached to the sulfur atom of the sulfonylurea group by means of a carbon atom of the ring, and wherein R1 may optionally be substituted with one or more substituents selected independently of the halo; -CN; -NO2; -N3; ​​-Rβ; -OH; -ORβ; -SH; -SRβ; -SO2Rβ; -NH2; -NHRβ; -N(Rβ)2; -CHO; -CORβ; -COOH; -COORβ; -OCORβ; -Rα-CHO; -Rα-CORβ; -R  COOH; -R  -COOR  ; -R  -OCOR  ; -NH-CHO; -NR  -CHO; -NH-COR  ; -NR  COR  ; -CONH2; -CONHR  ; -WITH(R  )2; -R  -NH-CHO; -R  -NR  -CHO; -R  NH-COR  ; -R  -NR  -COR  ; -R  -CONH2; -R  -CONHR  ; -R  -WITH(R  )2; a C3-7 cycloalkyl group optionally substituted with one or more C1-3 alkyl or C1-3 haloalkyl groups;a C3-7 cycloalkenyl group optionally substituted with one or more C1-3 alkyl or C1-3 haloalkyl groups; (FORMULAS); oxo (=O); or a C1-4 alkylene bridge; each -R  - is independently selected from an alkylene, alkenylene or alkynylene group, where the alkylene, alkenylene or alkynylene group contains from 1 to 6 carbon atoms in its main structure, and where the alkylene, alkenylene or alkynylene group may optionally be substituted with one or more halo and / or -R  groups; each -R  is independently selected from a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C2-6 cyclic group, and wherein each -R  may optionally be substituted with one or more C1-3 alkyl, C1-3 haloalkyl, C3-7 cycloalkyl, -O(C1-3 alkyl), halo, -CN, -C≡CH or oxo (=O) groups; each -R  is independently selected from a C1-6 alkyl or C1-3 haloalkyl group; each m is independently selected from 1, 2 or 3; each n is independently selected from 1, 2 or 3;and R2 is (FORMULA). 15 Claims follow;