Title - AN AQUEOUS COSMETIC COMPOSITION FOR PERSONAL CARE EXCLUDING ITS THERAPEUTIC USES

Abstract

A composition comprising itaconic acid, a surfactant selected from anionic, non-ionic, zwitterionic or amphoteric surfactants or mixtures thereof and at least 75% by weight of water.

Description

DESCRIPTIVE MEMORANDUM Field of invention The present invention relates to the area of ​​preservation for personal care, in particular to hair care compositions. Background of the invention In the personal care and cosmetics industry, there is a constant need for preservative chemicals, especially preservative chemicals that come from natural sources, are abundant and readily available. A large number of antimicrobial active compounds are already used in the personal care industry, but alternatives are still being sought. Not all antimicrobial agents have suitable preservative properties, and therefore, new preservative chemicals are particularly needed. It should be noted that substances used in the personal care field must be: toxicologically acceptable; easily tolerated by the skin; stable; largely and preferably completely odorless; economical to prepare (i.e., using standard processes and / or from standard precursors); easy to formulate (i.e., preferably liquid); and must not be detrimental to the final product. Gerardo Messerer - 20137826543 IF-2019-78234356-APN-ANP#INPI 1 Page 1 of 12 The present application has found a preservative chemical suitable for use with personal care compositions. Description of the invention The present invention relates to a composition comprising a short chain (C1 to C6), an unsaturated organic acid or a salt thereof having at least two carboxyl groups, and a surfactant selected from anionic, non-ionic, zwitterionic, or amphoteric surfactants, or mixtures thereof. The invention further relates to a method for preserving a composition according to any preceding claim by using: a short-chain (C1 to C6), unsaturated organic acid, or a salt thereof having at least two carboxyl groups. Detailed description of the invention The compositions of the invention comprise itaconic acid or a salt thereof. Preferably, the total level of itaconic acid in the total composition is from 0.05 to 7% by weight of the total composition, more preferably from 0.1 to 5% by weight, much more preferably from 0.2 to 3% by weight, for example from 0.05 to 0.25% by weight. Preferably, the composition further comprises a cyclic, aromatic or acyclic organic compound and / or terpene, more preferably the cyclic or acyclic compound comprises an aldehyde, ketone, amide, amine, alcohol and ester group. Preferably, the level of cyclic, aromatic or acyclic organic compound is 0.05 to 3% by weight of the total composition. IF-2019-78234356-APN-ANP#INPI 2 Page 2 of 12 In a preferred embodiment, the cyclic or acyclic organic compound comprises an aromatic compound, preferably the aromatic compound being benzoic acid or a salt thereof. In a second preferred embodiment, the composition further comprises a terpene and / or thymol, a particularly preferred terpene being terpineol. In a third embodiment, the composition comprises a cyclohexane or a derivative thereof. Preferably, the individual level of aromatic compound, benzoic acid or salt thereof or terpene is 0.05 to 3% by weight of the total composition. The compositions of the invention comprise at least 75% by weight, preferably at least 80% by weight, more preferably at least 85% by weight, and much more preferably at least 87% by weight of water, by weight of the total composition. Preferably, the compositions of the invention are free of denatured ethanol, preferably denatured alcohol. The composition according to the invention comprises a surfactant selected from anionic, non-ionic, zwitterionic or amphoteric surfactants or mixtures thereof. IF-2019-78234356-APN-ANP#INPI3 Page 3 of 12 Suitable anionic surfactants include alkyl sulfates, alkyl ether sulfates, alkaryl sulfonates, alkanoyl isethionates, alkyl succinates, alkyl sulfosuccinates, N-alkoyl sarcosinates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, and alpha-olefin sulfonates, especially their sodium, magnesium, ammonium, and mono-, di-, and triethanolamine salts. The alkyl and acyl groups generally contain 8 to 18 carbon atoms and may be unsaturated. Alkyl ether sulfates, alkyl ether phosphates, and alkyl ether carboxylates may contain 1 to 10 ethylene oxide or propylene oxide units per molecule, and preferably contain 2 to 3 ethylene oxide units per molecule. Examples of suitable anionic surfactants include sodium oleyl succinate, ammonium lauryl sulfosuccinate, ammonium lauryl sulfate, sodium dodecylbenzene sulfonate, triethanolamine dodecylbenzene sulfonate, sodium cocoyl isethionate, sodium lauryl isethionate, and sodium N-lauryl sarcosinate. The most preferred anionic surfactants are sodium lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine monolauryl phosphate, sodium lauryl ether sulfate 1EO, 2EO, and 3EO, ammonium lauryl sulfate, and ammonium lauryl ether sulfate 1EO, 2EO, and 3EO. Suitable nonionic surfactants for use in compositions of the invention may include condensation products of primary or secondary aliphatic (C8-C18) linear or branched-chain alcohols or phenols with alkylene oxides, generally ethylene oxide, and generally having from 6 to 30 ethylene oxide groups. Other suitable nonionic surfactants include mono- or di-alkyl alkanolamides, glycolipids preferably selected from the rhamnolipid and sophorolipid groups. IF-2019-78234356-APN-ANP#INPI 4 Page 4 of 12 Examples include: Amphoteric and zwitterionic surfactants suitable for use in compositions of the invention may include alkylamine oxides, alkyl betaines, alkylamidopropyl betaines, alkyl sulfobetaines (sultains), alkyl glycinates, alkyl carboxyglycinates, alkyl amphopropionates, alkylphoglycinates, alkylamidopropyl hydroxysultains, acyl taurates, and acyl glutamates, wherein the alkyl and acyl groups have from 8 to 19 carbon atoms. Examples include lauryl amine oxide, cocodimethylsulfopropyl betaine, and preferably lauryl betaine, cocamidopropyl betaine, coco mono- or diethanolamide, coco monoisopropanolamide, and sodium cocamphopropionate. In general, surfactants are present in shampoo compositions of the invention in an amount of 0.1 to 50%, preferably 5 to 30%, more preferably 10% to 25% by weight. Preferably, the weight ratio of anionic surfactant, preferably alkyl ether sulfates, to unsaturated organic acid or salt thereof, preferably itaconic acid, is 200:1 to 2:1 Preferably, the weight ratio of amphoteric or zwitterionic surfactant, preferably betaine, to unsaturated organic acid or salt thereof, preferably itaconic acid, is from 100:1 to 1:1. The compositions of the invention are preferably personal care compositions, more preferably shampoo compositions. IF-2019-78234356-APN-ANP#INPI5 Page 5 of 12 The compositions of the invention may comprise a silicone conditioning agent, preferably in the form of emulsified droplets to improve the conditioner's performance. Suitable silicones include polydiorganosiloxanes, in particular polydimethylsiloxanes designated CTFA dimethicone. Also suitable for use in the compositions of the invention (especially shampoos and conditioners) are polydimethylsiloxanes with terminal hydroxyl groups, designated CTFA dimethiconol. Silicone rubbers having a slight degree of crosslinking, as described, for example, in WO 96 / 31188, are also suitable for use in the compositions of the invention. The viscosity of the emulsified silicone itself (not the emulsion or the final hair conditioning composition) is normally at least 10,000 cSt at 25°C, preferably at least 60,000 cSt, much more preferably at least 500,000 cSt, and ideally at least 1,000,000 cSt. Preferably, the viscosity does not exceed 109 cSt for ease of formulation. The emulsified silicones for use in the shampoo compositions of the invention will normally have a D90 silicone droplet size in the composition of less than 30, preferably less than 20, more preferably less than 10 micrometers, and ideally from 0.01 to 1 micrometer. Silicone emulsions having an average silicone droplet size (D50) of 0.15 micrometers are generally referred to as microemulsions. The particle size of silicone can be measured using a technique of IF-2019-78234356-APN-ANP#INPI 6 Page 6 of 12. Laser light scattering, for example, using a Malvern Instruments 2600D Particle Sizer. Examples of suitable preformed emulsions include Xiameter MEM 1785 and DC2-1865 microemulsion available from Dow Corning. These are dimethiconol emulsions / microemulsions. Crosslinked silicone gums are also available in a preemulsified form, which is advantageous for simplifying formulation. An additional preferred class of silicones for inclusion in shampoos and conditioners of the invention are amino-functional silicones. An amino-functional silicone is understood to be a silicone containing at least one primary, secondary, or tertiary amine group, or one quaternary ammonium group. Examples of suitable amino-functional silicones include polysiloxanes designated CTFA amodimethicone. Specific examples of amino functional silicones suitable for use in the invention are DC2-8220, DC2-8166, and DC2-8566 aminosilicone oils (all from Dow Corning). Suitable quaternary silicone polymers are described in EP-A-0 530 974. A preferred quaternary silicone polymer is K3474, from Goldschmidt. Emulsions of amino-functional silicone oils with nonionic and / or cationic surfactants are also suitable. Pre-formed emulsions of amino-functional silicone are also available from silicone oil suppliers such as Dow Corning and General Electric. Specific examples include the IF-2019-78234356-APN-ANP#INPI 7 Page 7 of 12 cationic emulsion DC939 and non-ionic emulsions DC2-7224, DC2-8467, DC2-8177 and DC2-8154 (all ex Dow Corning). The total amount of silicone is preferably 0.01 to 10% by weight of the total composition, more preferably 0.1 to 5% by weight, much more preferably 0.5 to 3% by weight is a suitable level. Preferably, the weight ratio of silicone conditioning agent to short-chain, unsaturated organic acid is 20:1 to 1:4. The compositions of the invention may comprise additional ingredients such as cationic deposition polymer, preferably those selected from cationic cellulose and cationic guar derivatives. Other examples of ingredients found in compositions according to the invention include perfumes and pH adjusting agents. The invention will be illustrated by the following non-restrictive examples. Examples A shampoo base was prepared that had the formulation according to Table 1. Table 1: Shampoo formulation IF-2019-78234356-APN-ANP#INPI 8 Page 8 of 12 Active Ingredient Percentage Water 79.09 Carbomer 0.3 Sodium Laureth Sulfate 14 Cocoamidopropyl Betaine 1.6 C14 Guar Hydroxypropyl Trimethylammonium Chloride 0.08 C17 Guar Hydroxypropyl Trimethylammonium Chloride 0.03 Dimethiconol 1.5 Ethylene Glycol Distearate 1.25 Titanium Dioxide Coated Mica 0.05 Polyethylene Glycol 0.05 Fragrance 0.05 Organic Acid + pH Adjustment 2 Total 100 Itaconic acid, lactic acid, and citric acid were added to the conditioning composition at 0.5% by weight and 1% by weight of the total conditioner level. Sample preparation Itaconic acid, lactic acid, and citric acid were purchased from Sigma-Aldrich. Six samples of unpreserved conditioner were dosed separately with 0.5% and 1% (w / w) itaconic acid, citric acid, and lactic acid. One unpreserved sample was kept as a control. Each dosed product was adjusted to pH 5 using 50% sodium hydroxide (Sigma-Aldrich). IF-2019-78234356-APN-ANP#INPI9 Page 9 of 12 Challenge test method A modified stimulation test, based on the criteria of the European Pharmacopoeia (Ph. Eur. O EP) 5.1.3, was performed on a subsample of unpreserved product and on each dosed product. Table 2 summarizes the set of bacterial stimulation tests and the inoculum level. The microbial stimulation test was added to each sample container at a ratio of 1:100. The final inoculum concentration in the product should be 5 x 10⁶ CFU / g of the test product. Each product was mixed with a sterile spatula to ensure homogeneous distribution of the inoculum throughout. Table 2: Microbial stimulation test group and inoculum levels Grouping Microorganism Group inoculum CFU / ml Product inoculum CFU / G 1 Non-fermenting gram-negative bacteria Pseudomonas aeruginosa 7.1 x 108 CFU / ml 5 x 105-6 CFU / ml Burkholderia cepacia Strenotrophomonas sp 2 Fermenting gram-negative bacteria Enterobacter cloacae 5.2 x 108 CFU / ml 5 x 105-6 CFU / ml Klebsiella sp Both the inoculum level and the microorganism level within each sample were quantified using a Total Viable Count (TVC) pour plate method. IF-2019-78234356-APN-ANP#INPI 10 Page 10 of 12 On days 7, 14, 21, and 28, a 1:10 dilution was prepared using a subsample of each product, prepared separately in a peptone (0.1%) / Tween 80 (2%) neutralizing agent. A 1:10 and 1:100 dilution of each subsample was prepared, and plates produced at each dilution were poured onto tryptone soy agar (TSA). The TSA plates were incubated at 28°C for 48 hours and then examined for growth. Visible colonies were counted using a Quebec colony counter and recorded for analysis based on the stimulation test criteria. During the disposal of a product subsample for TVC, reinoculation was performed on days 7 and 14, and 5 x 10⁶ CFU / g of bacteria were reintroduced before mixing using a sterile spatula to homogenize the reinoculation. Table 3: Microbial stimulation test inoculation level Inoculum level (c1 fu / ml) Stimulation test group Microorganisms Day 0 Day 7 Day 14 Group 1 B.cepacia P.aeruginosa Strenotrophomonas sp 7.1E+08 7.8E+08 6.1E+08 Group 2 E.cloacae Klebsiella sp. 5.2E+08 4.1E+08 6.6E+08 IF-2019-78234356-APN-ANP#INPI 11 Page 11 of 12 Table 4: Destruction of the microbial stimulation test record Microbial Count Reduction Sample Grouping 7 days 14 days 21 days 28 days 1 Non-preserved shampoo 1 >5.61 3.01 <2.74 >5.74 2 3.94 4.61 4.72 >5.80 2 0.5% itaconic acid 1 >5.68 >5.56 >5.74 >5.74 2 >5.88 >5.69 >5.80 >5.80 3 1.0% itaconic acid 1 >5.61 >5.56 >5.74 >5.74 2 >5.88 >5.69 >5.80 >5.80 4 0.5% lactic acid 1 >5.61 >5.56 >5.74 >5.74 2 3.93 >5.69 >5.80 >5.80 5 1.0% lactic acid 1 >5.61 >5.56 >5.74 >5.74 2 >5.88 >5.69 >5.80 >5.80 6 0.5% citric acid 1 >5.61 3.84 >5.74 >5.74 2 4.88 >5.69 >5.80 >5.80 7 1.0% citric acid 1 >5.61 >5.56 >5.74 >5.74 2 4.97 >5.69 >5.80 >5.80 The table above demonstrates the improved preservation properties of itaconic acid compared to other organic acids. IF-2019-78234356-APN-ANP#INPI 12 Page 12 of 12 Argentine Republic - National Executive Branch 2019 - Year of Exports Additional Signature Sheet Graphic Report Number: IF-2019-782343 5 6-APN-ANP#INPI CITY OF BUENOS AIRES Friday, August 30, 2019 Reference: 20190101506 The document was imported by the GEDO system with a total of 12 page(s). Digitally signed by GESTION DOCUMENTAL ELECTRONICA - GDE DN: cn=ELECTRONIC DOCUMENTARY MANAGEMENT - GDE, c=AR, o=GOVERNMENT SECRETARY OF MODERNIZATION, ou=ADMINISTRATIVE MODERNIZATION SECRETARY, serialNumber=CUIT 30715117564 Date: 2019.08.30 03:34:46 -03'00' Mariela Flavia Gonnet Administrative Advisor National Patent Administration National Institute of Industrial Property Digitally signed by GESTION DOCUMENTAL ELECTRONICA GDE DN: cn=GEST10N ELECTRONIC DOCUMENTARY - GDE, c=AR, o=GOVERNMENT SECRETARY OF MODERNIZATION, ou=ADMINISTRATIVE MODERNIZATION SECRETARY, serialNumber=CUIT 30715117564 Date: 2019.08.30 03:34:46 -03'00'

Claims

1. An aqueous cosmetic composition for personal care, excluding its therapeutic uses, characterized in that it comprises i- 0.05 to 7% of the total composition of itaconic acid or a salt thereof and ii- a surfactant selected from: - anionic surfactant of the sodium lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine monolauryl phosphate, sodium lauryl ether sulfate 1EO, 2EO and 3EO, ammonium lauryl sulfate and ammonium lauryl ether sulfate 1EO, 2EO and 3EO group, - amphoteric and zwitterionic surfactants of the lauryl amine oxide, cocodimethylsulfopropyl betaine, lauryl betaine, cocamidopropyl betaine, coco mono- or diethanolamide, coco mono-isopropanolamide and sodium cocamphopropionate group, and iii- at ​​least 75% water, wherein The weight ratio of anionic surfactant to itaconic acid is 200:1 to 2:1, and the weight ratio of amphoteric or zwitterionic surfactant to itaconic acid is 100:1 to 1:

1. Ten claims follow.