ANTIBODIES AGAINST CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AND THEIR USES

Claims

Anti-CTGF (connective tissue growth factor) antibodies or antigen-binding fragments thereof. Examples of anti-CTGF antibodies address the need for treatments of conditions modulated by CTGF signaling. In some respects, anti-CTGF antibodies or antigen-binding fragments thereof are for therapeutic and / or diagnostic use, for example, in a subject who needs them, such as a human being.

1. An anti-CTGF antibody, or an antigen-binding fragment thereof, characterized in that it comprises: a light chain variable region comprising a light chain complementarity-determining region 1 (L-CDR1) having the amino acid sequence Y1-SSQSIVHYN-Y2-Y3-TYLE, wherein Y1 is K or R, Y2 is A, E, G or T and Y3 is K or N (SEQ ID No. 10), a light chain complementarity-determining region 2 (L-CDR2) having the amino acid sequence KVS-Z1-R-Z2-S, wherein Z1 is N or S and Z2 is A or F (SEQ ID No. 11), and a light chain complementarity-determining region 3 (L-CDR3), having the amino acid sequence FQGSHFPLT (SEQ ID No. 12);and a variable heavy chain region comprising a heavy chain complementarity-determining region 1 (H-CDR1) having the amino acid sequence DYYMA (SEQ ID No. 15), a heavy chain complementarity-determining region 2 (H-CDR2) having the amino acid sequence NINY-X1-GSRTDLL-X2-SLKS, wherein X1 is D, E, or Y and X2 is A, D, or E (SEQ ID No. 16), and a heavy chain complementarity-determining region 3 (H-CDR3) having the amino acid sequence DTSRGSYFDV (SEQ ID No. 17).

43. A pharmaceutical composition characterized in that it comprises the antibody or an antigen-binding fragment thereof according to any of the preceding claims and, optionally, a pharmaceutically acceptable carrier.

62. An isolated polynucleotide characterized in that it encodes a sequence comprising the variable region of the heavy chain and / or the variable region of the light chain of the antibody or an antigen-binding fragment thereof according to any of claims 1 to 42.

63. A plurality of isolated polynucleotides characterized in that it encodes a sequence comprising the variable region of the heavy chain and / or the variable region of the light chain of the antibody or an antigen-binding fragment thereof according to any of claims 1 to 42.

64. A vector characterized in that it comprises the polynucleotide according to claim 62 or the plurality of polynucleotides according to claim 63.

65. A plurality of vectors characterized in that it comprises the plurality of polynucleotides according to claim 63.

68. A host cell characterized in that it comprises the polynucleotide according to claim 62 or the plurality of polynucleotides according to claim 63.

87. A pharmaceutical composition characterized in that it comprises the antibody or an antigen-binding fragment thereof according to any of claims 73 to 86 and, optionally, a pharmaceutically acceptable carrier.