ANTIBODY-DRUG CONJUGATE AND USE THEREOF

Claims

A drug conjugate represented by formula (III). An isolated nucleic acid, wherein the isolated nucleic acid encodes the anti-CD38 antibody or the antigen-binding fragment thereof according to claim 35; furthermore, the nucleic acid encodes a heavy chain and / or a light chain of the anti-CD38 antibody or the antigen-binding fragment thereof according to claim 35; furthermore, the nucleic acid encodes a heavy chain variable region and / or a light chain variable region of the anti-CD38 antibody or the antigen-binding fragment thereof according to claim 35.A recombinant vector or expression vector, wherein the recombinant vector or expression vector comprises one or more nucleic acids according to claim 36; furthermore, the vector is suitable for the recombinant production of the anti-CD38 antibody or the antigen-binding fragment thereof according to claim 35, and, for example, the vector is a pcDNA vector, such as pCDNA3.1 and pCDNA3.

4. A host cell comprising one or more nucleic acids according to claim 36 or the recombinant vector or expression vector according to claim 37, wherein the host cell is, for example, a CHO cell or a 293 cell, such as Expi293.A method for producing the anti-CD38 antibody or the antigen-binding fragment thereof according to claim 35, wherein the method comprises culturing a host cell containing the encoding for a polypeptide chain of the antibody under conditions suitable for expression of the polypeptide chain, and optionally, the method further comprises assembling the polypeptide chain to produce a molecule under conditions suitable for assembling the polypeptide chain within the molecule; or culturing a host cell comprising the nucleic acid molecule according to claim 36 or the recombinant vector or expression vector according to claim 37, or culturing the host cell according to claim 38 under conditions suitable for expression of a chain of the antibody, and optionally recovering the antibody from the host cell (or a culture medium for the host cell).A pharmaceutical composition comprising the drug conjugate, or pharmaceutically acceptable salt thereof, or solvate, racemic mixture, enantiomer, diastereomer or tautomer thereof according to any one of claims 1 to 25, the drug conjugate, or pharmaceutically acceptable salt thereof, or solvate, racemic mixture, enantiomer, diastereomer or tautomer thereof according to any one of claims 32 to 34, the anti-CD38 antibody or antigen-binding fragment thereof according to claim 35, the nucleic acid according to claim 36, the recombinant vector or expression vector according to claim 37, the host cell according to claim 38, or the immune conjugate or immune fusion according to claim 40, and optionally a pharmaceutically acceptable adjuvant material such as a pharmaceutical carrier or a pharmaceutical excipient.