IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED ESCHERICHIA COLI SACCHARIDES AND USES THEREOF
Patent Information
- Application Number
- ARP20250100641
- Authority / Receiving Office
- AR · AR
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-02-14
- Filing Date
- 2025-03-10
- Publication Date
- 2026-09-16
Claims
In one aspect, an immunogenic composition comprising conjugated O-polysaccharide molecules derived from E. coli lipopolysaccharides. In one embodiment, the O-polysaccharide molecules are conjugated with streptococcal C5a peptidase (SCP). In some embodiments, the O-polysaccharide molecules are conjugated with SCP using click chemistry.
1. A pharmaceutical composition characterized in that it comprises a glycoconjugate, wherein the glycoconjugate comprises a streptococcal C5a peptidase carrier protein (SCP), or a functional fragment thereof, covalently linked to an E. coli saccharide, and wherein the saccharide comprises the structure of Formula O25b.
2. A pharmaceutical composition characterized in that it comprises a glycoconjugate comprising an E. coli saccharide, and an RNA molecule encoding a FimH-derived polypeptide, or a functional fragment thereof.
34. A pharmaceutical composition characterized in that it comprises a glycoconjugate and a CpG oligonucleotide, wherein the glycoconjugate comprises a streptococcal C5a peptidase carrier protein (SCP), or a functional fragment thereof, covalently linked to an E. coli saccharide, and wherein the saccharide comprises the structure of Formula O25b.