STING AGONISM FOR SPECIFIC ANTIGEN TOLERANCE
Patent Information
- Application Number
- ARP20250100705
- Authority / Receiving Office
- AR · AR
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-03-18
- Filing Date
- 2025-03-18
- Publication Date
- 2026-09-23
Claims
This application relates, in general, to compositions comprising antigens and activating agents of the cGAS stimulation pathway and uses thereof to induce or enhance tolerogenic immune responses to an antigen.
1. A composition comprising: (i) one or more antigens; and (ii) one or more cGAS-STING activating agents.
57. A composition comprising an effective amount of a composition comprising (i) one or more antigens; and (ii) one or more cGAS-STING activating agents to induce antigen-specific tolerance in a subject.
61. A composition comprising antigens and STING activating agent encapsulated in or coupled to carrier particles, wherein the carrier particles are liposomes.
63. A composition comprising antigens and STING activating agent encapsulated in or coupled to carrier particles, wherein the carrier particles are lipid nanoparticles.