ANTI-EPHRIN B2 ANTIBODIES AND METHODS OF USE

Claims

This document provides antibodies and antibody fragments that specifically bind to the ephrin B2 protein. The anti-ephrin B2 antibodies provided herein bind to the ephrin B2 protein with high affinity and specificity. Anti-ephrin B2 antibodies are considered effective for treating and preventing fibrosis in patients who require them.An anti-Ephrine B2 antibody comprising a heavy chain variable domain and a light chain variable domain, wherein said heavy chain variable domain comprises: a CDR H1 as set forth in SEQ ID No. 66, a CDR H2 as set forth in SEQ ID No. 67, and a CDR H3, wherein said CDR H3 is a variant of SEQ ID No. 68; wherein said light chain variable domain comprises: a CDR L1 as set forth in SEQ ID No. 69, a CDR L2 comprising LGS, and a CDR L3 as set forth in SEQ ID No. 70; and wherein said variant of SEQ ID No. 68 comprises the sequence of SEQ ID No. 68 including a substitution thereof at positions corresponding to position 4, position 6, position 10, and position 11 with respect to SEQ ID No. 68.