Novel thyromimetics

Abstract

Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, X1, X2, Y1, and Y2 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

Description

NOVEL THYROMIMETICS BACKGROUND Technical Field The invention relates to thyromimetic compounds and to products containing the same, as well as to methods of their use and preparation. Description of the Related Art Thyroid hormone (TH) is a key signal for oligodendrocyte differentiation and myelin formation during development, and also stimulates remyelination in adult models of multiple sclerosis (MS) (Calza et al., Brain Res Revs 48:339-346, 2005). However, TH is not an acceptable long-term therapy due to the limited therapeutic window in which remyelination can be achieved while avoiding the cardiotoxicity and bone demineralization associated with chronic hyperthyroidism. Some thyroid hormone analogs can activate thyroid hormone- responsive genes while avoiding the associated downsides of TH by exploiting molecular and physiological features of thyroid hormone receptors (Malm et al., Mini Rev Med Chem 7:79-86, 2007). These receptors are expressed in two major forms with heterogenous tissue distributions and overlapping but distinct sets of target genes (Yen, Physiol Rev 81:1097-1142, 2001). TRa is enriched in the heart, brain, and bone while TRP is enriched in the liver (O'Shea et al., Nucl Recept Signal 4:e011, 2006). It has also been reported that TH can inhibit the transforming growth factor beta (TGF-B) signaling, and, therefore, attenuate fibrotic responses (Alonso-Merino et al., Proc Natl Acad Sci U S A. 113(24):E3451-60, 2016). TGF-B is a cytokine with pleiotropic effects in tissue homeostasis that plays a key role in pathological processes such as fibrosis (Massagué, Nat Rev Mol Cell Biol. 13(10):616-630, 2012). By inhibiting TGF-P signalling, TR ligands or agonists could have beneficial effects to block the progression of fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) or systemic sclerosis (Varga et al., Curr Opin Rheumatol. 20(6): 720-728, 2008). Developing selective thyromimetics has been challenging due to the high sequence homology of thyroid hormone receptor subtypes; namely, only one amino acid residue on the internal surface of the ligand binding domain cavity varies between the al and B1 forms. Despite this challenge, several groups have reported TRB-selective agonists. Scanlan et al. identified GC-1 (sobetirome) as one of the first potent analogs to demonstrate significant TRB-selectivity in vitro (Chiellini et al., Chem Biol 5:299-306, 1998; Yoshihara et al., J Med Chem 46:3152-3161, 2003) and in vivo (Trost et al., Endocrinology 141:3057-3064, 2000; Grover et al., Endocrinology 145:1656-1661, 2004; Baxter et al., Trends Endocrinol Metab 15:154-157, 2004). As used herein, the term “sobetirome” refers to a synthetic diarylmethane derivative that was investigated clinically as a potential therapeutic for hypercholesterolemia (see U.S. Patent No. 5,883,294, which is incorporated by reference herein). Other names for sobetirome found in the literature and regulatory filings include QRX-431 and GC-1. Metabasis employs a similar core with a novel liver-targeting prodrug strategy in MBO7811 (Erion et al., PNAS 104(39), 15490-15495, 2007). Madrigal has reported TRpB-selective activity in vivo for MGL- 3196 (Taub et al., Atherosclerosis 230{2):373-380, 2013). KaroBio has reported on eprotirome (KB2115; Berkenstam et al., PNAS 105(2):663-668, 2008) and KB-141 (Ye et al., J Med Chem 46:1580-1588, 2003), both of which demonstrate improved TRB-selectivity in vitro. Further studies from this group highlight additional selective compounds (Hangeland et al., BMCL 14:3549-3553, 2004). Two TRB-selective agonists, identified as SKL-12846 and SKL-13784, have been reported to accumulate in the liver and to reduce cholesterol levels in rodents (Takahashi et al., BMC 22(1):488-498, 2014; Xenobiotica 2015, 1-9). Kissei has also reported selective compounds (Shiohara et af., BMC 20{11), 3622-3634, 2012). While progress has been made in this field, there remains a need in the art for further selective thyromimetic compounds, as well as to products containing the same, and for methods related to their use and preparation. BRIEF SUMMARY Disclosed herein are compounds according to Formula I: v2 x1 H O A x2 Cl ' 1 oY R! oq or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein RL, RZ, X!, X24, Y!, and Y? are as defined below. In an embodiment, a pharmaceutical composition is provided comprising a compound having the structure of Formula (1), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, in combination with a pharmaceutically acceptable carrier, diluent, or excipient. In an embodiment, the pharmaceutical composition is for use in treating a neurodegenerative disorder including neurodegenerative disorders classified as a demyelinating disease such as X-linked adrenoleukodystrophy or multiple sclerosis. In another embodiment, the pharmaceutical composition is for use in treating a medical condition associated increased activity of TGF-B, such as a fibrotic disease. In an embodiment, a method is provided for treating a neurodegenerative disorder in a subject in need thereof, comprising administering a compound having the structure of Formula (1), or a pharmaceutically acceptable salt or composition comprising the same. In some aspects, the neurodegenerative disorder can be classified as a demyelinating disease such as X-linked adrenoleukodystrophy or multiple sclerosis. In another embodiment, a method is provided for treating a medical condition associated with over-expression of TGF- in a subject in need thereof, comprising administering a compound having the structure of Formula (I), or a pharmaceutically acceptable salt or composition comprising the same. In some aspects, the medical condition associated with over-expression of TGF-B is a fibrotic disease. DRAWINGS Figure 1 indicates that the amide prodrugs Compound 16 & 17 provide higher brain levels of the parent acid Compound 15 than are achieved by dosing Compound 15 itself. DETAILED DESCRIPTION As mentioned above, the invention relates to thyromimetic compounds, to products comprising the same, and to methods for their use and synthesis. In one embodiment, compounds are provided having the structure of Formula (1): v2 x1 Hi O A CC ; ag LL} R oq or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y!and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY apie ol r -0 Rl. R!2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R and R*® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; and R?is lower alkyl, lower alkenyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein RY, R!°, R, and R? are each, independently, optionally substituted with one or more halo, lower alkyl, lower haloalkyl, cyano, -OR, =NR'R", =O, =S, =S(0).R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. The acid compounds of the present invention (R! = ~OR* and R= H) are active agonists selectively activating the TRB receptor. The amide compounds of the present invention (R! = -NR*R*) may act as substrates for the specific hydrolase enzyme fatty acid- amide hydrolase (FAAH), which cleaves the amide, liberating the thyromimetic. Thus, prodrug conversion to drug is enhanced in tissues that express high levels of FAAH such as the central nervous system. Figure 1 indicates that the amide prodrugs Compound 16 and 17 provides markedly higher brain levels of the parent acid Compound 15, than can be achieved by dosing Compound 15 itself. The ester compounds of the present invention (R* = OR and R% # H) are also prodrugs, typically processed through the action of esterases which may exist selectively in specific tissues. As used herein, “lower alkyl” means a straight chain or branched alkyl group having from 1 to 8 carbon atoms, in some embodiments from 1 to 6 carbon atoms, in some embodiments from 1 to 4 carbon atoms, and in some embodiments from 1 to 3 carbon atoms. Examples of straight chain lower alkyl groups include, but are not limited to, methyl, ethyl, n- propyl, n-butyl, n-pentyl-, n-hexyl, n-heptyl, and n-octyl groups. Examples of branched lower alkyl groups include, but are not limited to, isopropyl, iso-butyl, sec-butyl, t-butyl, neopentyl, isopentyl, and 2,2-dimethylpropyl groups. As used herein, “lower alkenyl” means a straight chain or branched alkenyl group having from 2 to 8 carbon atoms, in some embodiments from 2 to 6 carbon atoms, in some embodiments from 2 to 4 carbon atoms, and in some embodiments from 2 to 3 carbon atoms. Alkenyl groups are unsaturated hydrocarbons that contain at least one carbon-carbon double bond. Examples of lower alkenyl groups include, but are not limited to, vinyl, propenyl, isopropenyl, butenyl, pentenyl, and hexenyl. As used herein, “lower alkynyl” means a straight chain or branched alkynyl group having from 2 to 8 carbon atoms, in some embodiments from 2 to 6 carbon atoms, in some embodiments from 2 to 4 carbon atoms, and in some embodiments from 2 to 3 carbon atoms. Alkynyl groups are unsaturated hydrocarbons that contain at least one carbon-carbon triple bond. Examples of lower alkynyl groups include, but are not limited to, ethynyl, propynyl, butynyl, pentynyl, and hexynyl. “Halo" or “halogen” refers to fluorine, chlorine, bromine, and iodine. "Hydroxy" refers to -OH. “Cyano” refers to -CN. “Lower haloalkyl” refers to a lower alkyl as defined above with one or more hydrogen atoms replaced with halogen. Examples of lower haloalkyl groups include, but are not limited to, -CFs;, =CHF5, and the like. “Lower alkoxy" refers to a lower alkyl as defined above joined by way of an oxygen atom {(i.e., ~-O-(lower alkyl). Examples of lower alkoxy groups include, but are not limited to, methoxy, ethoxy, n-propoxy, n-butoxy, isopropoxy, sec-butoxy, tert-butoxy, and the like. "Lower haloalkoxy" refers to a lower haloalkyl as defined above joined by way of an oxygen atom (i.e., -O-{lower haloalkyl). Examples of lower haloalkoxy groups include, but are not limited to, ~OCF3, =OCHF;, and the like. "Cycloalkyl" refers to alkyl groups forming a ring structure, which can be substituted or unsubstituted, wherein the ring is either completely saturated, partially unsaturated, or fully unsaturated, wherein if there is unsaturation, the conjugation of the pi- electrons in the ring do not give rise to aromaticity. Examples of cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl groups. In some embodiments, the cycloalkyl group has 3 to 8 ring members, whereas in other embodiments the number of ring carbon atoms range from 3to 5, 3 to 6, or 3 to 7. Cycloalkyl groups further include polycyclic cycloalkyl groups such as, but not limited to, norbornyl, adamantyl, bornyl, camphenyl, isocamphenyl, and carenyl groups, and fused rings such as, but not limited to, decalinyl, and the like. "Cycloalkylalkyl" are alkyl groups as defined above in which a hydrogen or carbon bond of the alkyl group is replaced with a bond to a cycloalkyl group as defined above. “Aryl” groups are cyclic aromatic hydrocarbons that do not contain heteroatoms. Thus, aryl groups include, but are not limited to, phenyl, azulenyl, heptalenyl, biphenyl, indacenyl, fluorenyl, phenanthrenyl, triphenylenyl, pyrenyl, naphthacenyl, chrysenyl, biphenylenyl, anthracenyl, and naphthyl groups. In some embodiments, aryl groups contain 6- 14 carbons in the ring portions of the groups. The terms "aryl" and "aryl groups" include fused rings wherein at least one ring, but not necessarily all rings, are aromatic, such as fused aromatic-aliphatic ring systems (e.g., indanyl, tetrahydronaphthyl, and the like). In one embodiment, aryl is phenyl or naphthyl, and in another embodiment aryl is phenyl. "Carbocyclyl," “carbocycle,” or "carbocyclic" refers to alkyl groups forming a ring structure, which can be substituted or unsubstituted, wherein the ring is either completely saturated, partially unsaturated, or fully unsaturated, wherein if there is unsaturation, the conjugation of the pi-electrons in the ring may give rise to aromaticity. In one embodiment, carbocycle includes cycloalkyl as defined above. In another embodiment, carbocycle includes aryl as defined above. "Carbocyclealkyl" are alkyl groups as defined above in which a hydrogen or carbon bond of the alkyl group is replaced with a bond to a carbocycle group as defined above. Examples of carbocyclealkyl groups include, but are not limited to, cyclopropylmethyl, cyclobutylmethyl, benzyl, and the like. "Heterocyclyl,” "heterocycle," or "heterocyclic" refers to aromatic and non- aromatic ring moieties containing 3 or more ring members, of which one or more is a heteroatom such as, but not limited to, N, O, S, or P. In some embodiments, heterocyclyl include 3 to 20 ring members, whereas other such groups have 3 to 15 ring members. At least one ring contains a heteroatom, but every ring in a polycyclic system need not contain a heteroatom. For example, a dioxolanyl ring and a benzdioxolanyl ring system (methylenedioxyphenyl ring system) are both heterocyclyl groups within the meaning herein. Heterocyclyl groups also include fused ring species including those having fused aromatic and non-aromatic groups. A heterocyclyl group also includes polycyclic ring systems containing a heteroatom such as, but not limited to, quinuclidyl, and also includes heterocyclyl groups that have substituents, including but not limited to alkyl, halo, amino, hydroxy, cyano, carboxy, nitro, thio, or alkoxy groups, bonded to one of the ring members. A heterocyclyl group as defined herein can be a heteroaryl group or a partially or completely saturated cyclic group including at least one ring heteroatom. Heterocyclyl groups include, but are not limited to, pyrrolidinyl, furanyl, tetrahydrofuranyl, dioxolanyl, piperidinyl, piperazinyl, morpholinyl, pyrrolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridinyl, thiophenyl, benzothiophenyl, benzofuranyl, dihydrobenzofuranyl, indolyl, dihydroindolyl, azaindolyl, indazolyl, benzimidazolyl, azabenzimidazolyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, imidazopyridinyl, isoxazolopyridinyl, thianaphthalenyl, purinyl, xanthinyl, adeninyl, guaninyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, quinoxalinyl, and quinazolinyl groups. "Heterocyclealkyl" are alkyl groups as defined above in which a hydrogen or carbon bond of the alkyl group is replaced with a bond to a heterocycle group as defined above. "Heteroaryl" refers to aromatic ring moieties containing 5 or more ring members, of which, one or more is a heteroatom such as, but not limited to, N, O, and S. Heteroaryl groups include, but are not limited to, groups such as pyrrolyl, pyrazolyl, pyridinyl, pyridazinyl, pyrimidyl, pyrazyl, pyrazinyl, pyrimidinyl, thienyl, triazolyl, tetrazolyl, triazinyl, thiazolyl, thiophenyl, oxazolyl, isoxazolyl, benzothiophenyl, benzofuranyl, indolyl, azaindolyl, indazolyl, benzimidazolyl, azabenzimidazolyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, imidazopyridinyl, isoxazolopyridinyl, thianaphthalenyl, purinyl, xanthinyl, adeninyl, guaninyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinoxalinyl, and quinazolinyl groups. The terms "heteroaryl" and "heteroaryl groups" include fused ring compounds such as wherein at least one ring, but not necessarily all rings, are aromatic, including tetrahydroquinolinyl, tetrahydroisoquinolinyl, indolyl, and 2,3-dihydro indolyl. In one embodiment, compounds are provided having the structure of Formula (1), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl optionally substituted with one or more halo, cyano, -OR, -NR'R", =O, =S, -5(0):R" or -S(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In another embodiment, R? is unsubstituted lower alkyl. In a more specific embodiment, R? is methyl, ethyl, propyl, isopropyl, or butyl. In one embodiment, compounds are provided having the structure of Formula (mn: v2 x! rr ~ “Ore R! HO x2 oY om or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY aglb ol r -0 Ric R* and Rare each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein R*?, R™®, and R¢ are each, independently, optionally substituted with one or more halo, cyano, OR, =NR'R", =0, =5, =5(0)2R" or -5{0),OR', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (I-A): y2 x! R12 x= a» “YY Re | N. HO x2 oY R' 0 (I-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; and Rand R® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, =NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R*® taken together with the nitrogen atom to which they are attached form heterocycle; wherein R'? and R™ are each, independently, optionally substituted with one or more halo, cyano, -OR, =NR'R", =0, =5, -5{0)R" or =5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (II-B): v2 x! 1 a, vy! JX on HO x: oY R 0 (II-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; XZ is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; and Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein RX is optionally substituted with one or more halo, cyano, -OR), -NR'R", =0, =5, -S(0):R' or -S(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula ny: y2 x! T H QO A XC 1 oY 1 ® 0 {hy or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and YZ is not H; Rlis ~N| RY apie ol r -0 Rl Rand R° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Qis —C(R*R*)- or —{C(R3R*)},-; Ais aryl or heteroaryl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, =NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O}R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and R® are each, independently, H, lower alkyl, or lower haloalkyl; wherein R™?, R™®, RI, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR, -NR'R", =O, =S, =S{0):R' or =S(0)0R’, wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (IlI-A): y2 x1 (ir) Rie Tr T Q Y! oy Cr | HO x2 oN re 0 (I-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R* and R* are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NRR®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Q is —C(R*RY)- or —{C(R3R*)}>~; Ais aryl or heteroaryl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, =NR®R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, ~C(O)R?, -C(0)OR?, ~C{O)NR®R?, -NR2C{O)R®, -5{0),R?, or =5{0),0R?%; nis 0-5; and R? and R® are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R™°, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, -NR'R", =O, =5, -5(0)R' or -5(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (III-B): v2 x1 es) ral B Tr 7 HO x2 oN Ore o (11I-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; XZ is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Qis —C(R3R*)- or —{C(R3R¥)},-; Ais aryl or heteroaryl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, =NR®R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, ~C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -5{0),R?, or =5{0),0R?%; nis 0-5; and R? and R® are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR, -NR'R", =O, =5, -5(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (IV): Rac v2 x1 (RS n A j R3 R* ! HO x1 CC oY R! ov) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y!and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY agile ol r -0 Re. Rand R'° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, =NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R* taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR®R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S(0).R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R?, R™®, RIS, R3, R%, R%, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR', =NR'R", =0, =S, -5S(0)2R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (IV-A): 4 — v2 x1 (RS n A ) R3 R* A ® HO x! x: 2 ’ re | pis B, Rb 0 (IV-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and YZ is not H; Rand R® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, ~NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R*® taken together with the nitrogen atom to which they are attached form heterocycle; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR? -NR°R®, ~C(O)R?, -C(0)OR?, ~C{O)NR®Rt, -NR2C{O)R®, -5{0),R?, or =5{0),0R%; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R%°, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =S(0)R" or -5(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (IV-B): 4 = v2 x1 (ro n A ) R3 R* HO x1 CCC 1 oY I o. Rc 0 (IV-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y* and Y? is not H; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; R?® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O)R®, -S(0).R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R% R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, =NR'R", =0, =S, -5(0);R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (Vv): 22 Qt QQ (RO}— II Ql. 0 R® ; R* ! HO x! CL 1 oY R! © v) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Ql, Q% Q3 Q% and Q° are each, independently, CH, CRS, or N; X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY aRlb o r -0 Rie R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R*® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O}R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and R® are each, independently, H, lower alkyl, or lower haloalkyl; wherein R™?, R™, R'¢, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR, -NR'R", =O, =S, =S(0):R' or =S(0)0R’, wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (V-A): 2° Q4 "y2 x1 Ria yo E: Q2” Saf (RO—— Il "Ql. Qf ¥z x! R3 x 1a R4 2 2 Nib Ho x oR o coutically accentable icamar raremate hvdrate <alvate i © (v-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Ql, Q3 Q3 Q% and @° are each, independently, CH, CR®, or N; X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; XZ is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y* and Y? is not H; Rand R'° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R* taken together with the nitrogen atom to which they are attached form heterocycle; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR®R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR2R?, ~NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R22, R1°, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -5(0)R" or -S(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (V-B): JPR ~ Q4 Cy2 x1 ot 2” Nat RS In 5 Y: X Rr i yi! R* 2 O~ pio HO xX oY TR Oo ceuticallv accentable isamer racemate hvdrate solvate i © (v-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Q%, Q% Q3, Q% and Q° are each, independently, CH, CR®, or N; X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y!and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and YZ is not H; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR®R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR2Rt, ~NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =5(0)R' or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (V1): v2 x1 (RS + R3 R* ! HO x! oC 1 oY 1 ® ov) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y!and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y* and Y? is not H; Rlis -N RY apie ol r -0 Re. R!2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, ~NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R*® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, ~OR®, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S(0).R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R™?, R™®, R'¢, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR, -NR'R", =O, =S, =S{0):R' or =S(0),0R’, wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VI-A): v2 x! (RS R® R* : HO x! JC yi po | I No Rt 0 (VI-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y* and Y? is not H; Rand R are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; R?® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O}R®, -S(0).R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R'®, R* R%, R%, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, =NR'R", =0, =S, -5(0);R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VI-B): y2 x1 (Re R3 R* ! HO x! CC 1 oY T O. Rc o (VI-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O)R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R?, R%, RS, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =S(0)R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VI): ) Y? x! (Rel A | vt @ ® fd HO x2 oN" 0 (vi) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY apie ol r -0 Rie Rand Rare each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{Q}R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R'?, R™®, R!¢, R%, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =S(0)R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VII-A): Y2 x1 Ra (re “nds Y2 HO x1 XC A N TT “Rt o (VII-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; XZ is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR°R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R*® taken together with the nitrogen atom to which they are attached form heterocycle; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, =NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O}R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and R® are each, independently, H, lower alkyl, or lower haloalkyl; wherein R', R™®, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, =NR'R", =0, =S, -5(0);R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VII-B): (RE 7 A y2 HO’ x! CL 1 oY TY O. Re 0 (VII-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O}R®, -S(0).R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R'?, R™®, R!¢, R%, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =S(0)R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VI): Cob ; y2 As x! JC 1 oY 1 R 0 (vin) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y* and Y? is not H; Rlis -N RY aRlb o r -0 Rie R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, =OR?, -NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R* and R* taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®R?, -NR2C{O)R®, -S(0)R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R'?, R™®, R!¢, R%, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, OR’, =NR'R", =0, =S, =S(0)R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VIII-A): y2 x1 Ra (RS 2g Y2 “10 oO x! CC 1 O ~~ Ag Mn Rb o (VIII-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X* is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R* and R are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R*® taken together with the nitrogen atom to which they are attached form heterocycle; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR®, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®RP, -NRC{O}R®, -S(0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R', R'®, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, OR’, -NR'R", =0, =5, -5(0):R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of Formula (VIII-B): HO n 2) ¥* HO x1 CCL 1 oY I o. Rc o (VIII-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y!and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, ~OR?, -NR°R®, -C(O)R?, -C(O)OR?, -C{O)NR®RP, -NRC{O)R®, -S(0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R', R'®, RS, RS, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, -NR'R", =O, =5, -5(0)R" or -5{0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula (llI-A), Formula (1lI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Ris H. In one embodiment, compounds are provided having the structure of Formula (In), Formula (111-A), Formula (11-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is carbocycle. In one embodiment, R? is cyclopropyl or cyclobutyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula (llI-A), Formula (llI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl. In one embodiment, R? is methyl, ethyl, or propyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula {Ill-A), Formula {I1-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula {V-B), Formula (V1), Formula (VI-A), Formula (VI-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R® is ~OR®. In one embodiment, R? is H. In one embodiment, R® is lower alkyl. In a more specific embodiment, R? is methyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula (ll-A), Formula (Ill), Formula (111-A), Formula (IV), Formula (Iv-A), Formula (V), Formula (V-A), Formula (V1), Formula (VI-A), Formula (VII), Formula (VII-A), Formula (VII), Formula (VIII-A), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R! is =NR*2R® and Rt is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {ll-A), Formula (Ill), Formula (111-A), Formula (IV), Formula (Iv-A), Formula (V), Formula (V-A), Formula (V1), Formula (VI-A), Formula (VII), Formula (VII-A), Formula (VIII), Formula (VIII-A), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R* is =NR*R*® and R* is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {II-B}, Formula (lll), Formula (I1I-B), Formula (IV), Formula (IV-B), Formula (V), Formula (V-B), Formula (VI), Formula (VI-B), Formula (VII), Formula (VII-B), Formula (VIII), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R* is -OR and R¥ is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-B), Formula (Ill), Formula (I1I-B), Formula (IV), Formula (Iv-B), Formula (V), Formula (V-B), Formula (VI), Formula (VI-B), Formula (VII), Formula (VII-B), Formula (VII), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R* is OR! and Ris lower alkyl. In one embodiment, RI is methyl or ethyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (l1l-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is lower alkyl. In one embodiment, X! is methyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {II-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is halo. In one embodiment, X* is Cl or Br. In one embodiment, X* is Cl. In one embodiment, X* is Br. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula {VIl), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X! is lower haloalkyl. In one embodiment, X! is CFs. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (I1-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is lower alkenyl. In one embodiment, X! is vinyl; in another embodiment, X! is isopropenyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower alkyl. In one embodiment, X? is methyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {II-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is halo. In one embodiment, X? is Cl or Br. In one embodiment, X2 is Cl. In one embodiment, X? is Br. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower haloalkyl. In one embodiment, X2 is CFs. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (I1-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower alkenyl. In one embodiment, X? is vinyl; in another embodiment, X? is isopropenyl. In one embodiment, compounds are provided having the structure of any one of Formula (Ill), Formula {Ill-A), Formula {I1-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula (llI-A), Formula (llI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula {VIIl}, Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower alkyl substitued with -OR". In one embodiment, R'is H. In another embodiment, R' is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (Ill), Formula {III-A}, Formula {Il-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower haloalkyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula (llI-A), Formula (1lI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula {VII}, Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is —OR®. In one embodiment, R? is lower alkyl. In one embodiment, R? is lower haloalkyl. In one embodiment, compounds are provided having the structure of any one of Formula (lll), Formula {Ill-A), Formula {Il-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is -C(O)R?. In one embodiment, R? is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (I11), Formula (llI-A), Formula (llI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula {V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is -NR*C(O)R®. In one embodiment, R? is H and R® is lower alkyl. In one embodiment, R® is methyl. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula (llI-A), Formula (llI-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula {VIII}, Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is -C(O)OR®. In one embodiment, R? is lower alkyl. In one embodiment, R? is methyl or ethyl. In one embodiment, compounds are provided having the structure of any one of Formula (Ill), Formula {Ill-A), Formula {II-B}, Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is =5{0);R®. In one embodiment, R® is lower alkyl. In one embodiment, R?is methyl. In one embodiment, compounds are provided having the structure of any one of Formula (Ill), Formula {Ill-A), Formula {Il-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula {VII}, Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is halo. In one embodiment, at least one RS is F. In one embodiment, compounds are provided having the structure of any one of Formula (111), Formula {Ill-A), Formula {Il-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula {VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is cyano. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {II-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is halogen. In one embodiment, Y! is F. In one embodiment, Y! is Cl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is cyano. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {lI-A), Formula (1I-B), Formula (111), Formula {lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y is lower alkoxy. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula {1I-B), Formula (Ill), Formula (III-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is halogen. In one embodiment, Y2is F. In one embodiment, Y2 is Cl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {lI-A), Formula (1I-B), Formula (111), Formula {lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y? is cyano. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula {IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (1I-B), Formula (111), Formula (llI-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is lower alkoxy. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula (lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {lI-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIIl), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y!is F and Y2is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is Cl and Y? is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {lI-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is cyano and YZis H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (1I-B), Formula (111), Formula (llI-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is lower alkyl and Y? is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {II-A), Formula (1I-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is lower alkoxy and Y?is H. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is H and Y? is F. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (Il), Formula {lI-A), Formula (1I-B), Formula (111), Formula {lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VI), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y!is H and Y? is Cl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {II-A), Formula (II-B), Formula (111), Formula (l1l-A), Formula (I1-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is H and Y? is cyano. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (1I-B), Formula (111), Formula (l1I-A), Formula (ll-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is H and Y? is lower alkyl. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula (IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (V1), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VI1I-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is H and Y? is lower alkoxy. In one embodiment, compounds are provided having the structure of any one of Formula (1), Formula (11), Formula {lI-A), Formula (II-B), Formula (111), Formula (lll-A), Formula (II-B), Formula (IV), Formula (IV-A), Formula {IV-B), Formula (V), Formula (V-A), Formula (V-B), Formula (VI), Formula (VI-A), Formula (VI-B), Formula (VII), Formula (VII-A), Formula (VII-B), Formula (VIII), Formula (VIII-A), Formula (VIII-B), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y!is F and Y?is F. Representative compounds of Formula {I}, and Formulas {Il} through (VIII-B) as applicable, include the compounds listed in Table 1 below, as well as pharmaceutically acceptable salts thereof. To this end, representative compounds are identified herein by their respective “Compound Number”, which is sometimes abbreviated as “Compound No.”, “Cmpd. No.” or “No.” Representative Compounds STRUCTURE NAME F 1 - | methyl 2-(4-(2-fluoro-4- hydroxy-3- " methyl 2-(4-(2-fluoro-4- © @ hydroxy-3- 0. isopropylbenzyl)-3,5- HO ~ J y ) oY dimethylphenoxy)acetate oO T IN | 2-(4-2-uoro-4-hydroxy-3- | isopropylbenzyl)-3,5- dimethylphenoxy)acetic | 2-(4-(2-fluoro-4-] isopropylbenz OH dimethylpheno HO oY acid oO Ey OF C23 FE F 2-(4-((3"- PY O t (difluoromethoxy)-2-fluoro- | 0 CJ Cl 6-hydroxy-[1,1'-biphenyl]- OH 3-yl)methyl)-3,5- HO oY dimethylphenoxy)acetic an oT o © acid E | methyl 2-(4-(2-fluoro-3-(1- F (4-fluorophenyl)vinyl)-4- 3 2 DEE hydroxybenzyl)-3.5- O CO dimethylphenoxy)acetate 0. HO Cd oO F 2-(4-(2-fluoro-3-(1-(4- fluorophenyl)vinyl)-4- F MUHVW YY YY z | hvdroxybenzyl)-3.5- dimethylphenoxy)acetic | bi hydroxybenz; dimethylpheno OH acid HO oY oO STRUCTURE NAME F 2-(4-(2-fluoro-3-(1-(4- fluorophenyl)ethyl)-4- F ARM UVIATLY IU 1) ' | hydroxvbenzyl)-3.5- dimethylphenoxy)acetic J hydroxybenz; dimethylpheno: OH acid HO oY 0 F Bi x - 1 r ethyl 2-(3-bromo-4-(2- fluoro-4-hydroxy-3- r br ] ethyl 2-(3-bromo-4-(2- ® Cl fluoro-4-hydroxy-3- 0 isopropylbenzyl)-5- HO ~~ pl y ¢ ~ methvlphenoxy)acetate F N t I 2-(4-(2-fluoro-4-hydroxy-3- ® Cl isopropylbenzyl)-3-methyl- HO oN! 5-vinylphenoxy)acetic acid 0 v 1 2-(3-ethv]-4-(2-fluoro-4- hydroxy-3- j 2-(3-ethyl-4-(2-fluoro-4- | ® Cl hydroxy-3- OH isopropylbenzyl)-5- HO oY | methylphenoxy)acetic acid l » 0 I oo Bh Ll F 2-(3-ethyl-4-(2-fluoro-4- | hydroxy-3- hydroxy-3- C ) H isopropylbenzyl)-5- N 7 HO Oo ~ methylphenoxy)-N- ad rathedanatarmids ° methylacetamide F ~~ ethyl 2-(4-(2-fluoro-4- hydroxy-3- a 1 EEE SERS IE SEE LS ES hydroxy-3- @® ® | isopropylbenzyl)-3-methyl- | oOo 5-(prop-l-en-2- HO 0 (prop-1-en ~r vIinhenavvacetate o yl)phenoxy)acetate STRUCTURE NAME F ~F | 244-7 -Flnoro-4-hy 2-(4-(2-fluoro-4-hydroxy-3- isopropylbenzyl)-3-methyl- 5-(prop-1-en-2- i: L 2-(4~(2-fluoro-4-hydroxy-: ® Cl isopropylbenzyl)-3-methy OH 5-(prop-1-en-2- HO oY yD)phenoxy)acetic acid © ~ £ IR T | 2-(4-(2-fluoro-4-hydroxy-3- | isopropvlbenzyl)-3- " I | 2-(4-(2-fluoro-4-hydroxy-3- | ® Cl isopropylbenzyl)-3- OH isopropyl-5- HO oY | methylphenoxy)acetic acid l - oO F Cl TL methyl 2-(3.5-dichloro-4- | (2-fluoro-4-hydroxy-3- oak la AA a SE | isopropylbenzyl)phenoxy)a | Fr ol } methyl 2-(3.5-di § ® (2-fluoro-4-hyd 0. | isopropylbenzyl)y ~ 3 3 HO cl ° ~r cetate 0 F Cl | 2-(3,5-dichloro-4-(2-fluoro- | 4-hvdroxv-3- I ol y | 2-(3,5-dichloro-4-(2-fluoro- | J) C 4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid 0 F Cl 4-hvdroxv-3- Ln ol . : | 2-(3,5-dichloro-4-(2-fluo 4-hydroxy-3- A | isopropylbenzyl)phenox ~ ) ) hoy gl oY N-methylacetamide oO F £4 | 2+(3.5-dichloro-4-(2-fluoro- | 4-hydroxy-3- r ol 3 ' | 2-(3,5-dichloro-4-(2-fluoro Oi |i N isopropylbenzyl)phenoxy) ~ He cl oY | N.N-dimethvlacetamide Oo F Cl 4-hydroxy-3- i T | 2-(3,5-dichloro-4-(2-flu 4-hydroxy-3- ® ® RN | isopropylbenzyl)pheno: Ho cl oY N-ethylacetamide 0 STRUCTURE NAME F Cl 1 | 2-(3,5-dichloro-4-(2-fluoro- 4-hvdroxy-3- F ol 4 HO cl oY ~ LA i AA Ne isopropylbenzyl)phenoxy)- Y N-ethyl-N-methylacetamide F I rT oo F Cl ” | 2-(3,5-dichloro-4-(2-fluoro- CJ J) " 4-hydroxy-3- N ~~ isopropylbenzyl)phenoxy)- Ho cl oy F N-(2-fluoroethyl)acetamide 2 a APN N ~E isopropylbenzyhphenoxy)- ] N-(2-fluoroethyl)acetamide F Cl 1 | 2-(3,5-dichloro-4-(2-fluoro- 4-hydroxy-3- i i | 2-(3,5-dichloro-4-(2-fluoro- HO al oo” | isopropylbenzyl)phenoxy)- 11 N-methoxvacetamide 0 F Cl | 2-(3,5-dichloro-4-(2-fluoro- 4-hvdroxv-3- F Ol | <4-(3,5-dichloro-4-(Z-1luoro- 4-hydroxy-3- N | isopropylbenzyl)phenoxy)- HO cl oY 0” N-methoxy-N- o methylacetamide E cl | 5-03 5 -dichlarod-(2-f: | 2-(3,5-dichloro-4-(2-fluoro- 4-hvdroxv-3- v ol | <=(3,2=dIChIOro=-4-( 2-tiuoro- 4-hydroxy-3- @ J) 3 | isopropylbenzyl)phenoxy)- “— NN HO” al oY TN ~~ NN- o dimethylacetohydrazide F F cl 2+(3,5-dichloro-4-((3"- wh (difluoromethoxy)-2-fluoro- Fe O OD 6-hydroxy-[1,1"-biphenyl]- Ho cl oN 3-ylymethyl)phenoxy)acetic a acid 2-(3,5-dichloro-4-((2,2'- F coo . ol difluoro-6-hydroxy-5'- (trifluoromethyl)-[1,1'- F 7 a 2-(3,5-dichloro-4-((2,2"- OO . difluoro-6-hydroxy-5'- FsC 0) ) (trifluoromethyl)-[1,1'- biphenyl]-3- OH = HO cl oY | v)methyl)phenoxy)acetic oO acid STRUCTURE NAME F 2-(3,5-dichloro-4-((5'- E Y FE cl (difluoromethoxy)-2,2'- difluoro-6-hydroxy-[1,1'- | F 2-(3,5-dichloro-4-((5'- E 2 F cl (difluoromethoxy)-2,2'"- Ao ® Cl difluoro-6-hydroxy-[1,1'- biphenyl]-3- OH phony Ho cl oY vl)methyl)phenoxy)acetic o ) © acid | ethyl 2-3,5-dichloro-4-(2- fluoro-3-(4-fluorobenzyl)- CO ARAVA AAR F Cl ’ 1 Ba | hydroxybenzyl)phenoxy)ac | IT E wl B 4 oO. ctate HO cl oY ~ 0 F | 2+(3,5dichoro~4-(2+fluoro- | F Cl 3-(4-fluorobenzv])=4- T r ol S=(4-tluorobenzyl)-a- | hydroxybenzyl)phenoxy)ac | OD C oH etic acid HO cl oY 0 F | 2+(3,5-dichloro-4-(2-fluoro- | 3-(1-(4- F Cl th a L | ~ fluorophenyl)vinyl)-4- F ul AN Tr ’ fluorophenyl)vinyl)-4- | hydroxybenzyl)phenoxy)ac | OH etic acid HO cl oY oO STRUCTURE NAME F 2-(3,5-dichloro-4-(2-fluoro- 3-(1-(4-fluorophenyl)ethyl)- F Cl Jimi ' 1 4- Ir Fr ul LE - 1 CJ Cl | hydroxybenzyl)phenoxy)ac | OH etic acid HO cl oY 0 E | ethyl 2+(3,5-dichloro-4-(2- | fluoro-3-(1-(4- Cl F Cl AEM z | ~ fluorophenyl)propyl)-4- TR A A Ld Lf NITY lg Voss | hydroxybenzyl)phenoxy)ac | F wl » IT = fluorophenyl)p | hydroxybenzyl)p 0 ctate HO cl oy 0 EF | 2-(3,5-dichloro-4-(2-fluoro- | 3-(1-(4- F Cl RS : | ~ fluorophenyl)propyl)-4- La | ® in 7 } T fluorophenyl)propyl)-4- ® ® | hydroxybenzyl)phenoxy)ac | OH etic acid HO cl oY 0 F | ethyl 2+(3,5-dichloro-4-(2- | fluoro-3-(1-(4- Cl F cl nRLLRNA LA el REE ¥ | ~ fluorophenyl)butyl)-4- a OE SPS Sal | hydroxybenzyl)phenoxy)ac | Tr 7 fluorophenyl)t etate HO cl oO oO STRUCTURE NAME EF | 2-(3,5-dichloro-4-(2-fluoro- | 3-(1-(4- F Cl =~ AEA ' | ~ fluorophenvl)butyl)-4- Trou 7 fluorophenyl)butyl)-4- | hydroxybenzyl)phenoxy)ac | OH etic acid HO cl oY oO F cl - | ethyl 2-(3-chloro-4-(2- fluoro-4-hydroxy-3- = ol 1 ethyl 2-(3-chloro-4-(2- ® Cl fluoro-4-hydroxy-3- oO isopropylbenzyl)-5- HO ~~ pl y c ~ methvlphenoxy)acetate 0 F Re be | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- r ol 1 | 2-(3-chloro-4-(2-fluoro-4- | ® C hydroxy-3- OH isopropylbenzyl)-5- HO FT08EY oY | methylphenoxy)acetic acid l oO | EA | F a | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- > ol | Z=(3=-Cchloro=-4-( Z-1luQro- hydroxy-3- CJ ® H isopropylbenzyl)-3- HO 0 yr Ns methylphenoxy)-N- 0 methylacetamide F cl | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- rm wl | 4-{3-chloro-4-( Z-tluoro-4 hydroxy-3- CJ ® 4 isopropylbenzyl)-5- HO oY ic methylphenoxy)-N,N- o dimethylacetamide F Br ¥ | ethyl 2-(3-bromo-5-chloro- | 4-(2-fluoro-4-hydroxy-3- | isopropylbenzyl)phenoxy)a y 1 | ethyl 2-(3-bromo- ® Cl 4-(2-fluoro-4-hy o_ | isopropylbenzyl)y hey cl oY cetate 0 STRUCTURE NAME F Br 1 | 2-(3-bromo-5-chloro-4-(2- | fluoro-4-hydroxy-3- r br 4 | 2-(3-bromo-5-chloro-4-(2- | CJ C fluoro-4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid N F ~ ' ho ethyl 2-(3-chloro-4-(2- fluoro-4-hydroxy-3- 1 ethyl 2-(3-chloro-4-(2- OD O fluoro-4-hydroxy-3- o_~ isopropylbenzyl)-5- HO cl oY vinylphenoxy)acetate 0 = ~~ F nN NN | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- i 1 | 2-(3-chloro-4-(2-fluoro-4- ® Cl hydroxy-3- OH isopropylbenzyl)-5- Ho cl oY vinyvlphenoxy)acetic acid oO v | 2-(3-chloro-5-ethyl-4-(2- fluoro-4-hydroxy-3- i; 2-(3-chloro-5-ethyl-4-(2- | ® Cl fluoro-4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO al oY cetic acid | 0 e | 2-(3-chloro-5-ethyl-4-(2- fluoro-4-hydroxy-3- H u 2-(3-chloro-5-ethyl-4-(2- | C ) H fluoro-4-hydroxy-3- N isopropylbenzyl)phenoxy)- | HO cl oY > | N-methylacetamide | ~~ F ' tr ethyl 2-(3-chloro-4-(2- fluoro-4-hydroxy-3- 4 1 ethyl 2-(3-chloro-4-(2- 0) 0D) fluoro-4-hydroxy-3- o_- | isopropylbenzyl)-5-(prop-1- | HO cl oY en-2-yl)phenoxy)acetate 0 STRUCTURE NAME ~¢F F Yo hd | 2-(3chloro-4-(2-fluoro-4- | or 1 | 2-(3-chloro-4-(2-tlu ) OD hydroxy-3- OH isopropylbenzyl)-5-( HO cl oY | en-2-vl)phenoxy)ace bi | . i = PN OH isopropylbenzyl)-5-(prop-1- cl oY en-2-yl)phenoxy)acetic acid o F ~ | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- or ! Lo TT em meme hydroxy-3- ® Cl oh isopropylbenzyl)-5- HO cl 0 isopropylphenoxy)acetic 0 acid Cl Cl Co chloro-4-hvdroxy-3- ul ul | ethyl 2-(3,5-dichloro-4-(2- | J) CJ chloro-4-hydroxy-3- o- | isopropylbenzyl)phenoxy)a HO cl oY conte I o cl cl | 2-(3,5-dichloro-4-(2-chloro- | 4-hydroxy-3- ul wl | 2-(3.5-dichloro-4-(2-chloro- | J) C 4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid oO Cl methyl 2-(3,5-dichloro-4- | (4-hvdroxv-2-methyvl-3- Cl methyl 2-(3,5-dichloro-4- | © CC (4-hydroxy-2-methyl-3- Oo (prop-1-en-2- HO a oY | vl)benzyl)phenoxy)acetate | Cl methyl 2-(3,5-dichloro-4- (4-hydroxy-3-isopropyl-2- methylbenzyl)phenoxy)acet ul ; methyl 2-(3,5-¢ § @ | (4-hydroxy-3-is o methylbenzyl)pl ~ vibenzy HO cl oN 0 { 5] 2-(3,5-dichloro-4-(4- hydroxy-3-isopropyl-2- | methylbenzyDphenoxy)acet | wl . 2-(3,5-dichlorc J) C hydroxy-3-isopr OH methylbenzyl)phe HO cl oY ic acid oO STRUCTURE NAME Cl o” | ethyl 2-(3,5-dichloro-4-(4- | hydroxy-3-isopropyl-2- 1 T | ethyl 235-dichloro-4-(4- | ® CO hydroxy-3-isopropyl-2- 0. methoxybenzyl)phenoxy)ac HO cl oY te I Oo Cl o” 2-(3.5-dichloro-4-(4- hydroxy-3-isopropyl-2- 7 T 2-(3,5-dichloro-4-(4- ® OC hydroxy-3-isopropyl-2- OH | methoxybenzyl)phenoxy)ac HO cl oY etic acid | o CN Ci methyl 2-(3,5-dichloro-4- | (2-cyano-4-hydroxy-3- AE RRA MRR | isopropylbenzyl)phenoxy)a | WIN ol methyl 2-(3,5-di ® i (2-cyano-4-hyd 0 | isopropylbenzyl)y ~ 3 3 HO cl o ~Nr cetate 0 CN Cl | 2-(3,5-dichloro-4-(2-cyano- | 4-hvdroxv-3- UN ol | 2-(3.5-dichloro-4-(2-cyano- | ® C 4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid oO ethyl 2-(2-fluoro-4-(4- hvdroxy-3- E ethyl 2-(2-fluoro-4-(4- hydroxy-3- wl CY isopropylbenzyl)-3,5- Ji dimethylphenoxy)acetate fe] | 2-(2-fluoro-4-(4-hydroxy-3- | isopropylbenzyl)-3,5- dimethylphenoxy)acetic F | 2-(2-fluoro-4-(4- ) OC isopropylbenz OH dimethylpheno: HO oY acid 0 | 2-(2-fluoro-4-(4-hydroxy-3- | H " isopropylbenzyl)-3,5- E | 2-(2-fluoro-4-(4-hydrox ® ® isopropylbenzyl)-3,; N dimethylphenoxy)-N HO 0 ~ 3 y ~ methylacetamide 0 STRUCTURE NAME | 2-(2-fluoro-4-(4-hydroxy-3- | isopropylbenzyl)-3,5- F | 2-(2-fluoro-4-(4-hydrox; ® ) , isopropylbenzyl)-3,5- N dimethylphenoxy)-N,) Ho 0 ~ 5 AN dimethylacetamide 0 Cl ethyl 2-(3,5-dichloro-2- fluoro-4-(4-hvdroxy-3- MG LEE ili aati | isopropylbenzyl)phenoxy)a | 5 F ethyl 2-(3,5-dic fluoro-4-(4-hyd TOC. | isopropylbenzyl)y 1 cetate oO Cl | 23, 5-dichloro-2-fluoro-4- | (4-hydroxy-3- wl # | 2-3, 5dichloro-2-fluoro-4- | J) Cl (4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid 0 Cl | 2-(3.5-dichloro-2-fluoro-4- | il E | 2-(3.5-dichloro-2-fluoro ie a o ~rS | isopropylbenzyl)phenox ji N-methvlacetamide 0 Cl | 2-(3.5-dichloro-2-fluoro-4- | (4-hydroxv-3- ol F | 2-(3.5-dichloro-2-fluoro-4- ® ® . (4-hydroxy-3- N isopropylbenzyl)phenoxy) ~ 2. cl oY | N,N-dimethylacetamide oO Br | ethyl 2+(3-bromo-5-chloro- | 2-fluoro-4-(4-hydroxy-3- | isopropylbenzyl)phenoxy)a Br F | ethyl 2-(3-bromo- ® Cl 2-fluoro-4-(4-hy oO | isopropylbenzyl)y ho el oY cetate 0 7“ | ethyl 2-(3-chloro-2-fluoro- | 4-(4-hvdroxy-3- 1 F | ethyl 2-(5-chloro-2-fluor 4-(4-hydroxy-3- o_- isopropylbenzyl)-3- HO cl oY vinylphenoxy)acetate 0 STRUCTURE NAME Z 2-(5-chloro-2-fluoro-4-(4- | hydroxy-3- ) F | 2-(5-chloro-2-fluoro-4-(4- ® Cl hydroxy-3- OH isopropylbenzyl)-3- HO a oY vinyvlphenoxy)acetic acid 0 | ethyl 2-(5-chloro-3-ethyl-2- l fluoro-4-(4-hydroxy-3- SA HRY. Dt woo | isopropylbenzyl)phenoxy)a | F | ethyl 2-(5-chloro- ® O fluoro-4-(4-hyd o_- | isopropylbenzyl)y HO cl ° SN cetate 0 2-(5-chloro-3-¢thyl-2- fluoro-4-(4-hydroxy-3- 2-(5-chloro-3-ethyl-2- ® OC F fluoro-4-(4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a | HO cl oY cetic acid 0 ~¢ | ethyl 2-(3-chloro-2-fluoro- | 4-(4-hvdroxy-3- 7 | ethyl 2-(3-chloro-2-tluoro- 1 @ OC F 4-(4-hydroxy-3- o_- | isopropylbenzyl)-3-(prop-1- | HO cl oN en-2-yl)phenoxy)acetate 0 ~F | 2-(5-chloro-2-fluoro-4-(4- | L | 2-(3-chloro-2-tluorc 0 Cl F hydroxy-3- OH isopropylbenzyl)-3-( Ho cl oY | en-2-yl)phenoxy)ace isopropylbenzyl)-3-(prop- 1- en-2-yl)phenoxy)acetic acid oO ~ | ethyl 2-(5-chloro-2-fluoro- | 4-(4-hvdroxy-3- I F | ethyl 2-(5-chloro-2-fluoro- 4-(4-hydroxy-3- o_- isopropylbenzyl)-3- HO cl oY isopropylphenoxy)acetate 0 STRUCTURE NAME ~ | 2-(5-chloro-2-fluoro-4-(4- | hydroxy-3- ! I Ait AA sn ae Re F hydroxy-3- ® Cl isopropylbenzyl)-3- HO cl Ca isopropylphenoxy)acetic 11 id o acid Z | ethyl 2-(3-chloro-2-fluoro- | 4-(4-hydroxy-3- isopropvlbenzvl)-5- vinvlphenoxy)acetate Xe F fo) Z isopropvlbenzvl)-5- vinvlphenoxy)acetic acid | | 2-(3-chloro-2-fluoro-4-(4- | ® OC hydroxy-3- OH isopropylbenzyl)-5- " ) 3 3 NS) cl oN vinyvlphenoxy)acetic acid | F 0 ERLE WATE Spel are: | isopropylbenzyl)phenoxy)a | cetate | ethyl 2-(3-chloro-S-sthyl-2- | fluoro-4-(4-hydroxy-3- ou | isopropylbenzyphenoxyla | HO cl oY cetate F 0 Er LEN. Be RAIN NT | isopropylbenzyl)phenoxy)a | cetic acid 2-(3-chloro-5-ethyl-2- ® O fluoro-4-(4-hydroxy-3- OH | isopropylbenzyl)phenoxy’ HO cl oN cetic acid F 0 ~F | isopropylbenzyl)-3-(prop-1- | en-2-yl)phenoxy)acetate r | ethyl 2-(3-chloro-2-fluoro- | CO ® 4-(4-hydroxy-3- ow | isopropylbenzy1)-5-(prop-1- | HO cl oY en-2-yl)phenoxy)acetate F oD STRUCTURE NAME ~F hd | 2-(3-chloro-2-fluoro-4-(4- ® Cl hydroxy-3- OH isopropylbenzyl)-5-(prop-1- HO Cl oN | en-2-v])phenoxy)acetic acid isopropylbenzyl)-5-(prop-1- en-2-yl)phenoxy)acetic acid F 0 ~~ isopropylbenzyl)-3- isopropvlphenoxy)acetate Tr | ethyl 2-(3-chloro-2-fluoro- CO ® 4-(4-hydroxy-3- o_- isopropylbenzyl)-5- HO cl oY isopropylphenoxy)acetate F fo) isopropvlbenzvl)-5- isopropvlphenoxy)acetic ~ | 2-(3-chloro-2-fluoro-4-(4- hydroxy-3- ® OC isopropylbenzyl)-5- HO cl oN oH isopropylphenoxy)acetic ra 1 1 3 F ° acid E ethyl 2-(3,5-dichloro-2- fluoro-4-(3-(4- Cl fluorobenzyl)-4- T T fluorobenzyl)-4- ® O F | hydroxybenzyl)phenoxy)ac 0. etate HO cl oy 0 F | 2+(3.5-dichloro-2-fluoro-4- Cl © (3-(4-fluorobenzyl)-4- I rl (2-(a-Tluorooenzyi)-4- F | hydroxybenzyl)phenoxy)ac ® Cl etic acid HO al oY oH 0 STRUCTURE NAME FE ethyl 2-(3,5-dichloro-2- fluoro-4-(3-(1-(4- Cl fluorophenvl)butyl)-4- na Por el ly SR LO JV | hydroxybenzyl)phenoxy)ac | T 7 fluorophenyl)t 0 etate HO al oy 0 F | 2-(3.5-dichloro-2-fluoro-4- | (3-(1-(4- Cl fluorophenyl)butyl)-4- Cl LE T 7 fluorophenyl)butyl)-4- | hydroxybenzyl)phenoxy)ac | H etic acid HO cl oN oO F AY a | ethyl 2-(3.5-dichloro-4-((3" | F 2) cl | ethyl 2-35-dichloro-4-((3™ | A F (difluoromethoxy)-6- Fro ® OD ydroxy-[1,biphenyl]-3- | HO cl wy yhmethyl)-2- o fluorophenoxy)acetate 0 ~ fluorophenoxy)acetate EA cl 2-(3.5-dichloro-4-((3'- (difluoromethoxy)-6- F cl 2-(3,5-dichloro-4-((3- A F (difluoromethoxy)-6- Foo CJ Cl | hydroxy-{1,1'-biphenyl]-3- | HO al oy" yhmethyl)-2- o fluorophenoxy)acetic acid | Cl ethyl 2-(2,3,5-trichloro-4- | ol a ethyl 2-(2,3,5-trichloro-4- | ® Cl (4-hydroxy-3- o_~ | isopropylbenzyl)phenoxy)a HO cl oY cetate I oO STRUCTURE NAME Cl 2-(2.3,5-trichloro-4-(4- hydroxy-3- isopropylbenzyl)phenoxy)a | ol al 2-(2,3,5-trichloro ® Cl hydroxy-3- OH isopropylbenzyl)ph HO cl oY cetic acid oO Cl ethyl 2-(3,5-dichloro-4-(4- | hydroxy-3- ol ethyl 2-(3,5-dichloro-4-(4 ® CJ hydroxy-3- oOo isopropylbenzyl)-2- Ho ¢ oY methylphenoxy)acetate oO £3 2-(3.5-dichloro-4-(4- hydroxy-3- L 2-(3,5-dichloro-4-(4- J) Cl hydroxy-3- 2 isopropylbenzyl)-2- Ho “ oY methylphenoxy)acetic acid l F : - | _ ethyl 2-(2-fluoro-4-(2- fluoro-4-hydroxy-3- i F ethyl 2-(2-fluoro-4-(2- J) Cl fluoro-4-hydroxy-3- o._~ isopropylbenzyl)-3,5- H y y © 0 ~ dimethvlphenoxy)acetate 0 a i i | F 2-(2-fluoro-4-(2-fluoro-4- | hvdroxy-3- » A A A A a NL REE RR F hydroxy-3- 9 isopropylbenzyl)-3,5- HO oY dimethylphenoxy)acetic 0 acid F 2-(2-fluoro-4-(2-fluoro-4- | hydroxy-3- B 1 HN EN ATT RA SRA F hydroxy-3- oy isopropylbenzyl)-3,5- HO oY ~ dimethylphenoxy)-N- 0 methylacetamide F 2-(2-fluoro-4-(2-fluoro-4- | hydroxy-3- 21 AE ARRMAA TAA ARE F hydroxy-3- N isopropylbenzyl)-3,5- HO oY *% dimethylphenoxy)-N,N- 0 dimethylacetamide STRUCTURE NAME F Cl ethyl 2-(3,5-dichloro-2- | isopropylbenzyl)phenoxy)a | r ol ethyl 2-(3,5-a1chlo F fluoro-4-(2-fluor ® @ a hydroxy-3- HO cl oY ~ | isopropylbenzyl)phe 0 | cetate F Cl I | 23, 5-dichloro-2-fluoro-4- | (2-fluoro-4-hvdroxy-3- r ol ' 5 | 243.5-dichloro-2-fluoro-4- | CJ Cl (2-fluoro-4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO cl oY cetic acid oO F iC | 2-(3.5-dichloro-2-fluoro-4- | i T 7 | 2-(3.5-dichloro-2-fluoro J) Cl i (2-fluoro-4-hydroxy-3 N isopropylbenzyl)phenox ~ Ho cl oY | N-methvlacetamide oO F Cl | 2-(3.5-dichloro-2-fluoro-4- | (2-fluoro-4-hydroxy-3- Y T F | 2-(3.5-dichloro-2-fluoro-4- ® § (2-fluoro-4-hydroxy-3- N isopropylbenzyl)phenoxy) ~ Ho cl oY | N.N-dimethvlacetamide fo} PPE a | ethyl 2-(3.5-dichloro-4-((5" | F F F a | ethyl 2-(3.5-dichloro-4-((5*- A F (difluoromethoxy)-2,2'- Fo J) ® difluoro-6-hydroxy-[1,1' HO cl oO tipten 3 hmethy 2 3 fluorophenoxy acetate o | fluorophenoxy)acetate A A Bi 2-(3,5-dichloro-4-((5'- (difluoromethoxy)-2.2'- F F F a 2-(3,5-dichloro-4-((5'- F (difluoromethoxy)-2.2"- F~ ro ® Cl | difluoro-6-hydroxy-[1,1- OH| biphenyl]-3-yl)methyl)-2- HO” ci oy | biphenyll-3-vhmethyl)-2- oO STRUCTURE NAME E ethyl 2-(3,5-dichloro-2- fluoro-4-(2-fluoro-3-(4- AAS Ae LI F cl b ' | _ fluorobenzyl)-4- hydroxybenzyl)phenoxy)ac | ro T r fluorobenzy hydroxybenzyl)p oO etate HO cl oN 0 F 2-(3.5-dichloro-2-fluoro-4- | (2-fluoro-3-(4- F Cl Ae MAMET ' | _ fluorobenzyl)-4- hydroxybenzyl)phenoxy)ac | T h iil # fluorobenzyl) hydroxybenzyl)phe H etic acid Ho cl oy 0 F 2-(3,5-dichloro-2-fluoro-4- | (2-fluoro-3-(4- F Cl As BMA z | _ fluorobenzyl)-4- hydroxybenzyl)phenoxy)- | N-methylacetamide 1 Ek wl F OHO: HO cl CE 0 F ethyl 2-(3,5-dichloro-2- fluoro-4-(2-fluoro-3-(1-(4- | F Cl ARAVA Ae MAAMTRATT 3 | _ fluorophenyl)vinyl)-4- hydroxybenzyl)phenoxy)ac | r ul 3 I P fluorophenyl)y hydroxybenzyl)p 0 ctate Ho cl oY 0 STRUCTURE NAME E 2-(3,5-dichloro-2-fluoro-4- | (2-fluoro-3-(1-(4- F Cl Ae MRVIMVTEVEAT : | _ fluorophenvl)vinyl)-4- hydroxybenzyl)phenoxy)ac | rx T fluorophenyl)vir CJ ® R hydroxybenzyl)phe OH etic acid HO a oY 0 F 2-(3.5-dichloro-2-fluoro-4- | (2-fluoro-3-(1-(4- F Cl Ad RL le 5 | _ fluorophenyl)ethyl)-4- hydroxybenzyl)phenoxy)ac | = ul y , Tr 4 E fluorophenyl)eth hydroxybenzyl)phe OH etic acid Ho cl oY 0 F Cl S$ 7 ethyl 2-(3-chloro-2-fluoro- | ANA 4-(2-fluoro-4-hydroxy-3- r ul 1 F ethyl 2-(3-chloro-2-fluoro § @ 4-(2-fluoro-4-hydroxy-3- o._~ isopropylbenzyl)-5- Ho oY methylphenoxy)acetate oO F cl Te 2~(3-chloro-2-fluoro-4-(2- | fluoro-4-hvdroxy-3- Y 7 " 2+(3-chloro-2-fluoro-4-2- | J) Cl fluoro-4-hydroxy-3- OH isopropylbenzyl)-5- bo oY methylphenoxy)acetic acid l oO SE EH F cl 2-(3-chloro-2-fluoro-4-(2- | fluoro-4-hydroxy-3- 5 ol 4=(3-Chloro-4-Tiuoro-4-{ F fluoro-4-hydroxy-3- ® ® + isopropylbenzyl)-5- HO oY ~ methylphenoxy)-N- 0 methylacetamide F ' F ethyl 2-(5-chloro-2-fluoro- | ANY 4-(2-fluoro-4-hydroxy-3- 1 F ethyl 2-(5-chloro-2-fluoro § Cl 4-(2-fluoro-4-hydroxy-3- o_~ isopropylbenzyl)-3- Ho cl oY methylphenoxy)acetate 0 STRUCTURE NAME F ’ | _ 2-(5-chloro-2-fluoro-4-(2- fluoro-4-hydroxy-3- 1 F 2-(5-chloro-2-fluoro-4-(2- ® Cl fluoro-4-hydroxy-3- OH isopropylbenzyl)-3- Ho ¢ oY methylphenoxy)acetic acid 0 TT ER F 2-(5-chloro-2-fluoro-4-(2- fluoro-4-hydroxy-3- hl og EL EN EAS Re F fluoro-4-hydroxy-3- @ ® By isopropylbenzyl)-3- HO cl oY ~ methylphenoxy)-N- 0 methylacetamide Cl ethyl 2-(3-chloro-2-fluoro- 4-(4-hydroxy-3- T F ethyl 2-(3-chloro-2-fluoro ® @ 4-(4-hydroxy-3- Oo isopropylbenzyl)-5- ho 0 ~~ methvlphenoxy)acetate 0 Cl 2-(3-chloro-2-fluoro-4-(4- hydroxy-3- wl F 2-(3-chloro-2-fluoro-4-(4- J) Cl hydroxy-3- OH isopropylbenzyl)-5- HO - - oY methylphenoxy)acetic acid oO EL TT rT To RA Tir et Ree TH F Cl 2-(3-chloro-2-fluoro-4-(2- fluoro-4-hvdroxy-3- M wl Z=(5=-ChIoro=-2-1Iuoro=-4-{ F fluoro-4-hydroxy-3- § J] + isopropylbenzyl)-5- HO oY ~ methylphenoxy)-N- 0 methvlacetamide ethyl 2-(5-chloro-2-fluoro- 4-(4-hvdroxy-3- F ethyl 2-(5-chloro-2-fluoro ) @ 4-(4-hydroxy-3- o_ isopropylbenzyl)-3- bs of oY methylphenoxy)acetate 0 2-(5-chloro-2-fluoro-4-(4- hydroxy-3- F 2-(5-chloro-2-fluoro-4-(4- ® CO hydroxy-3- OH isopropylbenzyl)-3- HO cl oO - - ~ methylphenoxy)acetic acid oO STRUCTURE NAME | 2-(5-chloro-2-fluoro-4-(4- | hydroxy-3- I £=(2=CNI0rO=2-T1UOTO=4={ F hydroxy-3- ) [) i isopropylbenzyl)-3- HO cl oY > methylphenoxy)-N- 0 methylacetamide ~¢ 1 athui 208 nb bie a ! F | ethyl 2-(3-chloro-2-tluoro- 4-(2-fluoro-4-hydroxy-3- o_- | isopropylbenzyl)-3-(prop-1 HO cl oN en-2-yl)phenoxy)acetate ~¢F F " y R hd _ | 2-(5-chloro-2-fluoro-4-(2- | J | | 2-(5-chloro-2-fluoro-4-( ® Cl F fluoro-4-hydroxy-3- OH isopropylbenzyl)-3-(prop HO cl oY | en-2-yl)phenoxy)acetic a lJ A OH isopropylbenzyl)-3-(prop-1- cl oY | en-2-vl)phenoxy)acetic acid 0 F ~ Io moe may | ethyl 2-(5-chloro-2-fluoro- | 4-(2-fluoro-4-hydroxy-3- a | F | ethyl 2-(5-chloro-2-fluoro- ® O 4-(2-fluoro-4-hydroxy-3- o_- isopropylbenzyl)-3- Ho cl © ~ isopropylphenoxy)acetate 0 - L F ~ | 2-(5-chloro-2-fluoro-4-(2- | fluoro-4-hydroxy-3- on I A AORN TELAT A Rh F fluoro-4-hydroxy-3- ® Cl o isopropylbenzyl)-3- H : 3 HO cl 0 isopropylphenoxy)acetic ~r ad o acid ° PS | 2-(4-(2-fluoro-4-hydroxy-3- | Hy " isopropylbenzyl)-3,5- b | 2-(4-(2-fluoro-4-hydrox H isopropylbenzyl)-3, N dimethylphenoxy)-N ~ 3 ) HO oY methylacetamide STRUCTURE NAME F ethyl 2-(2,3-difluoro-4-(4- | hydroxy-3- 1 F | ethyl 2-(2,3-difluoro-4-(4 J gi hydroxy-3- o isopropylbenzyl)-5- HO ~ oY methylphenoxy)acetate 0 F 2-(2,3-difluoro-4-(4- hydroxy-3- J F 2-(2,3-difluoro-4-(4- J CJ hydroxy-3- GH isopropylbenzyl)-5- HO . ' oY | methylphenoxy)acetic acid l ethyl 2-(2,5-difluoro-4-(4- | F | ethyl 2-(2,5-difluoro-4-( @ Cl hydroxy-3- oOo isopropylbenzyl)-3- HO F 0 Prop} > ~ swath YnThah Avnet al: °o methylphenoxy)acetate 2-(2,5-difluoro-4-(4- hydroxyv-3- F 2-(2,5-difluoro-4-(4- hydroxy-3- HO FE oy! isopropylbenzyl)-3- 0 | methylphenoxy)acetic acid l N° 2-(4-(2-fluoro-4-hydroxy-3- isopropylbenzyl)-3-methyl- 5-(prop-1-en-2- F ~ 2-(4-(2-fluoro-4-hydro: isopropylbenzyl)-3-me H 5-(prop-1-en-2- HO oN yD)phenoxy)-N- o methylacetamide F N° | 2:4-2-fluoro-4-hydroy 2-(4-(2-flyoro-4-hydroxy-3- isopropylbenzyl)-3-methyl- 5-(prop-1-en-2- F a LIA mee SLA), | x1 isopropylbenzyl)-3-met | 5-(prop-1-en-2- HO oN Dphenoxy)-N,N- o dimethylacetamide F ~ | 2-(4-2-fluoro-4-hydroxy-3- | isopropvlbenzyl)-3- F YT |tmemim ibis ya IO isopropylbenzyl)-3- H isopropyl-5- HO’ oY NS methylphenoxy)-N- 0 methylacetamide STRUCTURE NAME FN 2:(23-difluoro-4-(4- hydroxy-3- N 1 co hydroxy-3- | isopropylbenzyl)-5- HO oN methylphenoxy)-N- o methvlacetamide F 2-(2,3-difluoro-4-(4- hydroxy-3- F 2-(2,3-difluoro-4-(4- F hydroxy-3- a isopropylbenzyl)-5- HO oY ~ methylphenoxy)-N- 0 methylacetamide 2-(2,5-difluoro-4-(4- hydroxy-3- 2-(2,5-difluoro-4-(4- F hydroxy-3- H isopropylbenzyl)-3- ® Cl RN 3 ) HO F oY > methylphenoxy)-N- o methvlacetamide 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- F “ 2-(3-chloro-4-(2-fluoro J hydroxy-3- CY ) H isopropylbenzyl)-5- HO Cl oY NJ vinylphenoxy)-N- 0 methylacetamide 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- F Zz 2-(3-chloro-4-(2-fluoro- | hydroxy-3- CY ) | isopropylbenzyl)-5- HO Cl oN Le vinylphenoxy)-N.N- 0 dimethylacetamide 2-(3-chloro-5-ethyl-4-(2- | fluoro-4-hydroxy-3- isopropylbenzyl)phenoxy)a | F 2-(3-chloro-5-ethy 2) @ fluoro-4-hydrox NH, isopropylbenzyl)ph Ho of YY cetamide F ) 2-(3-chloro-S-cthyl-4-(2- fluoro-4-hydroxy-3- 1] <-(3-chloro->-cthyl-4-(2- fluoro-4-hydroxy-3- J @ N isopropylbenzyl)phenoxy) HO ol oY N.N-dimethvlacetamide 0 STRUCTURE NAME 2-(3-chloro-5-ethyl-4-(2- | fluoro-4-hydroxy-3- H E 2-(3-chloro-5-ethyl-4-2- | fluoro-4-hydroxy-3- CJ g i | isopropylbenzyl)phenoxy)- | ho cl oY 7 N-cyclopropylacetamide [eo] E 1-(azetidin-1-y1)-2-(3- | isopropylbenzyl)phenoxy)et | F I=(azeuain=1=yi)=2- “XIX | chloro-5-ethyl-4-(2-f J 2) 4-hydroxy-3- HO Cl ~~ | isopropylbenzyl)phen 0 han-1-one | isopropylbenzylphenoxy)- | F 2-(3-chloro-5-ethyl-4-(2 J 2] W fluoro-4-hydroxy-3- N isopropylbenzyl)phenox; HO Cl Oo * ~ y Y Fe N-cyclohexylacetamide 0 ~~ AVA WIMVRTVAY ldbb dt TIM F } 2-(3-chloro-5-ethyl-4-Q2- | F 2-(3-chloro-5-ethyl-4-Q2- | 2) 2) 0 fluoro-4-hydroxy-3- N._.0, isopropylbenzyl)phenoxy)- HO cl oY Ip | N-(3.,4-dimethylisoxazol-5- 0 vl)acetamide cl | 2-(3chloro-2-fluoro-4-(4- | hvdroxy-3- cl | 2-(3-chloro-2-fluoro-4- F hydroxy-3- 2) 2] H isopropylbenzyl)-5- HO oN methylphenoxy)-N- 0 methylacetamide 0 methylacetamide F Cl Vo oo wou = | 2+(3.5-dichloro-4-(2-fluoro- | 4-hvdroxy-3- F ol | 2+(3,5~dichoro~4-(2+fluoro- | @® 2 4-hydroxy-3- NH, | isopropylbenzyl)phenoxy)a HO cl oY cetamide 0 Cl ethyl 2-(5-chloro-2,3- F o ethyl 2-(5-chloro-2,3- difluoro-4-(4-hydroxy-3- Ho F oN ON | isopropylbenzyl)phenoxy)a E 5 cetate STRUCTURE NAME Cl | 2-(5-chloro-2,3-difluoro-4- | (4-hydroxy-3- o | 2-(5-chloro-2,3-difluoro-4- | @® O (4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO F & oY cetic acid | ethyl 2-(3-chloro-2,5- difluoro-4-(4-hydroxy-3- | isopropylbenzyl)phenoxy)a gl F ethyl 2-(3-chlo difluoro-4-(4-hy NO | isopropylbenzyl)y 1 cetate 0 Cl | 2-3-chloro-2,5-difluoro-4- | (4-hydroxy-3- ig | 2:(3-chloro-2,5-difluoro-4- | 2) ig (4-hydroxy-3- OH | isopropylbenzyl)phenoxy)a HO F oY cetic acid 0 F ~ | 2~(3-chloro-4-(2-fluoro-4- | hydroxy-3- F he I &={2-CNIoTO-4-{ £-TIUOro-4 hydroxy-3- | isopropylbenzyl)-5- HO cl oY hi isopropylphenoxy)-N- o methylacetamide F ~ | 2-(3chloro-4-(2-fluoro-d- | hvdroxyv-3- h 1 So hydroxy-3- | isopropylbenzyl)-5- HO’ cl oN isopropylphenoxy)-N,N- 0 dimethvlacetamide | 2-(3chloro-4-(2-fluoro-d- | hvdroxy-3- F ~~ | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- | | isopropylbenzyl)-5-(prop-1- | HO cl oy en-2-yl)phenoxy)-N- 0 methylacetamide v ~# | 2-(3chloro-4-(2-fluoro-d- | hydroxy-3- F ~ | 2-(3-chloro-4-(2-fluoro-4- | hydroxy-3- | | isopropylbenzy1)-5-(prop-1- | HO cl oS en-2-yl)phenoxy)-N,N- 0 dimethylacetamide STRUCTURE NAME Cl 2-(5-chloro-2,3-difluoro-4- | (4-hydroxy-3- o 2-(5-chloro-2,3-difluoro @® ) (4-hydroxy-3- NH isopropylbenzyl)phenox ho F ) oY N-methylacetamide 2-(3-chloro-2,3-difluoro-4- | i ~~ (4-hydroxy-3- o F 2-(3-chloro-2,5-difluoro: 2) 2] a (4-hydroxy-3- N isopropylbenzyl)phenox ~ ) ) HO E oY N-methylacetamide 0 2-(3-chloro-2-fluoro-4-(4- | hydroxy-3- A 2-(3-chloro-2-fluoro-4- hydroxy-3- J g H isopropylbenzyl)-5- HO’ cl oY NS vinylphenoxy)-N- F o methylacetamide 2-(3-chloro-2-fluoro-4-(4- | hydroxy-3- x 2-(3-chloro-2-fluoro-4-( hydroxy-3- J J | isopropylbenzyl)-5- HO cl oY Ns vinylphenoxy)-N.N- F o dimethylacetamide 2-(3-chloro-5-ethy1-2- fluoro-4-(4-hvdroxy-3- isopropylbenzyl)phenoxy)- | 2-(3-chloro-5-ethyl-2- fluoro-4-(4-hydroxy-3 i isopropylbenzyl)phenox H ~ pha , 0 Y N-methylacetamide 2-(3-chloro-5-¢thyl1-2- fluoro-4-(4-hvdroxy-3- aml SMITTY I J g fluoro-4-(4-hydroxy-3- | ; N isopropylbenzyl)phenoxy) ~ HO cl i oY N,N-dimethylacetamide 2~(5-chloro-2-fluoro-4-(4- | hydroxy-3- “ 2-(5-chloro-2-fluoro-4- F hydroxy-3- J CJ | isopropylbenzyl)-3- HO’ Cl oY NA vinylphenoxy)-N- 0 methylacetamide STRUCTURE NAME 2~(5-chloro-2-fluoro-4-(4- | hydroxy-3- “ 2-(5-chloro-2-fluoro-4-(: F hydroxy-3- J Cl | isopropylbenzyl)-3- HO cl oN vinylphenoxy)-N,N- 0 dimethvlacetamide 2~(3-chloro-2-fluoro-4-(4- | hydroxy-3- “ 2-(3-chloro-2-fluoro-4- hydroxy-3- 2) J H isopropylbenzyl)-5- HO’ Cl oN vinylphenoxy)-N- F oO ethylacetamide 2-(3-chloro-2-fluoro-4-(4- | hydroxy-3- “ 2-(3-chloro-2-fluoro-4-(: hydroxy-3- CJ) CJ H isopropylbenzyl)-5- HO Cl oY N ~"g vinylphenoxy)-N-(2- F 0 fluoroethyl)acetamide 2-(3.5-dichloro-2-cyano-4- | (4-hydroxy-3- isopropylbenzyl)phenoxy)a | ? ZN 2-(3.5-dichloro-2-c 2) 2] (4-hydroxy-’ OH isopropylbenzyl)ph HO cl oY cetic acid 0 Cl isopropylbenzyl)phenoxy)a | cetic acid 1 ZN 2-(3.5-dichloro-2-cyano-4- | Z g ig (4-hydroxy-3- OH isopropylbenzyl)phenoxy)a Ho @ oY cetic acid | ethyl 2-3 5-dichloro-4-(4- | hvdroxy-3- | ¢ 4 ethyl 2-(3,5-dichloro-4-(4- 2) 2) hydroxy-3- o_- isopropylbenzyl)-2- ho ci oY methoxyphenoxy)acetate 0 cl 2-(3,5-dichloro-4-(4- hydroxy-3- cl ; 2-(3,5-dichloro-4-(4- o hydroxy-3- g 2) isopropylbenzyl)-2- HO Cl oy" methoxyphenoxy)acetic o acid | cme | NAME STRUCTURE NO Cl 2-(3.5-dichloro-4-(4- Z ~ 0 hydroxy-3- 167 “ Co H isopropvlbenzyl)-2- methoxyphenoxy)-N- methvlacetamide a 0 ; HO cl oN 0 “Isomer” is used herein to encompass all chiral, diastereomeric or racemic forms of a structure, unless a particular stereochemistry or isomeric form is specifically indicated. Such compounds can be enriched or resolved optical isomers at any or all asymmetric atoms as are apparent from the depictions, at any degree of enrichment. Both racemic and diastereomeric mixtures, as well as the individual optical isomers can be synthesized so as to be substantially free of their enantiomeric or diastereomeric partners, and these are all within the scope of certain embodiments of the invention. The isomers resulting from the presence of a chiral center comprise a pair of nonsuperimposable- isomers that are called “enantiomers.” Single enantiomers of a pure compound are optically active (i.e., they are capable of rotating the plane of plane polarized light and designated R or §). “Isolated optical isomer” means a compound which has been substantially purified from the corresponding optical isomer(s) of the same formula. For example, the isolated isomer may be at least about 80%, at least 80% or at least 85% pure by weight. In other embodiments, the isolated isomer is at least 90% pure or at least 98% pure, or at least 99% pure by weight. “Substantially enantiomerically or diastereomerically” pure means a level of enantiomeric or diastereomeric enrichment of one enantiomer with respect to the other enantiomer or diastereomer of at least about 80%, and more specifically in excess of 80%, 85%, 90%, 95%, 98%, 99%, 99.5% or 99.9%. The terms "racemate" and "racemic mixture" refer to an equal mixture of two enantiomers. A racemate is labeled “(+)” because it is not optically active (i.e., will not rotate plane-polarized light in either direction since its constituent enantiomers cancel each other out). All compounds with an asterisk (*) adjacent to a tertiary or quarternary carbon are optically active isomers, which may be purified from the respective racemate and / or synthesized by appropriate chiral synthesis. A "hydrate" is a compound that exists in combination with water molecules. The combination can include water in stoichiometric quantities, such as a monohydrate or a dihydrate, or can include water in random amounts. As the term is used herein a "hydrate" refers to a solid form; that is, a compound in a water solution, while it may be hydrated, is not a hydrate as the term is used herein. A "solvate" is similar to a hydrate except that a solvent other that water is present. For example, methanol or ethanol can form an "alcoholate", which can again be stoichiometric or non-stoichiometric. As the term is used herein a "solvate" refers to a solid form; that is, a compound in a solvent solution, while it may be solvated, is not a solvate as the term is used herein. “Isotope” refers to atoms with the same number of protons but a different number of neutrons, and an isotope of a compound of Formula (1) includes any such compound wherein one or more atoms are replaced by an isotope of that atom. For example, carbon 12, the most common form of carbon, has six protons and six neutrons, whereas carbon 13 has six protons and seven neutrons, and carbon 14 has six protons and eight neutrons. Hydrogen has two stable isotopes, deuterium {one proton and one neutron) and tritium (one proton and two neutrons). While fluorine has a number of isotopes, fluorine 19 is longest-lived. Thus, an isotope of a compound having the structure of Formula (1) includes, but not limited to, compounds of Formula {I) wherein one or more carbon 12 atoms are replaced by carbon-13 and / or carbon-14 atoms, wherein one or more hydrogen atoms are replaced with deuterium and / or tritium, and / or wherein one or more fluorine atoms are replaced by fluorine-19. "Salt" generally refers to an organic compound, such as a carboxylic acid or an amine, in ionic form, in combination with a counter ion. For example, salts formed between acids in their anionic form and cations are referred to as “acid addition salts”. Conversely, salts formed between bases in the cationic form and anions are referred to as “base addition salts.” The term "pharmaceutically acceptable" refers an agent that has been approved for human consumption and is generally non-toxic. For example, the term “pharmaceutically acceptable salt" refers to nontoxic inorganic or organic acid and / or base addition salts (see, e.g., Lit et al., Salt Selection for Basic Drugs, Int. J. Pharm., 33, 201-217, 1986) (incorporated by reference herein). Pharmaceutically acceptable base addition salts of compounds of the invention include, for example, metallic salts including alkali metal, alkaline earth metal, and transition metal salts such as, for example, calcium, magnesium, potassium, sodium, and zinc salts. Pharmaceutically acceptable base addition salts also include organic salts made from basic amines such as, for example, N,N'dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine), tromethamine (tris- hydroxymethyl methylamine), and procaine. Pharmaceutically acceptable acid addition salts may be prepared from an inorganic acid or from an organic acid. Examples of inorganic acids include hydrochloric, hydrobromic, hydriodic, nitric, carbonic, sulfuric, and phosphoric acids. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, aromatic, aromatic aliphatic, heterocyclic, carboxylic, and sulfonic classes of organic acids, examples of which include formic, acetic, propionic, succinic, glycolic, gluconic, lactic, malic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzoic, anthranilic, 4-hydroxybenzoic, phenylacetic, mandelic, hippuric, malonic, oxalic, embonic (pamoic), methanesulfonic, ethanesulfonic, benzenesulfonic, panthothenic, trifluoromethanesulfonic, 2-hydroxyethanesulfonic, p- toluenesulfonic, sulfanilic, cyclohexylaminosulfonic, stearic, alginic, Bhydroxybutyric, salicylic, -galactaric, and galacturonic acid. Although pharmaceutically unacceptable salts are not generally useful as medicaments, such salts may be useful, for example as intermediates in the synthesis of compounds having the structure of Formula |, for example in their purification by recrystallization. In certain embodiments, the invention provides a pharmaceutical composition comprising a compound of the invention together with at least one pharmaceutically acceptable carrier, diluent, or excipient. For example, the active compound will usually be mixed with a carrier, or diluted by a carrier, or enclosed within a carrier which can be in the form of an ampoule, capsule, sachet, paper, or other container. When the active compound is mixed with a carrier, or when the carrier serves as a diluent, it can be solid, semi-solid, or liquid material that acts as a vehicle, excipient, or medium for the active compound. The active compound can be adsorbed on a granular solid carrier, for example contained in a sachet. Some examples of suitable carriers are water, salt solutions, alcohols, polyethylene glycols, polyhydroxyethoxylated castor oil, peanut oil, olive oil, gelatin, lactose, terra alba, sucrose, dextrin, magnesium carbonate, sugar, cyclodextrin, amylose, magnesium stearate, talc, gelatin, agar, pectin, acacia, stearic acid, or lower alkyl ethers of cellulose, silicic acid, fatty acids, fatty acid amines, fatty acid monoglycerides and diglycerides, pentaerythritol fatty acid esters, polyoxyethylene, hydroxymethylcellulose, and polyvinylpyrrolidone. Similarly, the carrier or diluent can include any sustained release material known in the art, such as glyceryl monostearate or glyceryl distearate, alone or mixed with a wax. As used herein, the term “pharmaceutical composition” refers to a composition containing one or more of the compounds described herein, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, formulated with a pharmaceutically acceptable carrier, which can also include other additives, and manufactured or sold with the approval of a governmental regulatory agency as part of a therapeutic regimen for the treatment of disease in a mammal. Pharmaceutical compositions can be formulated, for example, for oral administration in unit dosage form (e.g., a tablet, capsule, caplet, gelcap, or syrup); for topical administration {e.g., as a cream, gel, lotion, or ointment); for intravenous administration (e.g., as a sterile solution free of particulate emboli and in a solvent system suitable for intravenous use); or in any other formulation described herein. Conventional procedures and ingredients for the selection and preparation of suitable formulations are described, for example, in Remington: The Science and Practice of Pharmacy, 21% Ed., Gennaro, Ed., Lippencott Williams & Wilkins (2005) and in The United States Pharmacopeia: The National Formulary (USP 36 NF31), published in 2013. As used herein, the term “pharmaceutically acceptable carrier” refers to any ingredient other than the disclosed compounds, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof (e.g., a carrier capable of suspending or dissolving the active compound) and having the properties of being nontoxic and non- inflammatory in a patient. Excipients may include, for example: antiadherents, antioxidants, binders, coatings, compression aids, disintegrants, dyes (colors), emollients, emulsifiers, fillers (diluents), film formers or coatings, flavors, fragrances, glidants (flow enhancers), lubricants, preservatives, printing inks, sorbents, suspensing or dispersing agents, sweeteners, or waters of hydration. Exemplary excipients include, but are not limited to: butylated hydroxytoluene (BHT), calcium carbonate, calcium phosphate (dibasic), calcium stearate, croscarmellose, crosslinked polyvinyl pyrrolidone, citric acid, crospovidone, cysteine, ethylcellulose, gelatin, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, maltitol, mannitol, methionine, methylcelluloFse, methyl paraben, microcrystalline cellulose, polyethylene glycol, polyvinyl pyrrolidone, povidone, pregelatinized starch, propyl paraben, retinyl palmitate, shellac, silicon dioxide, sodium carboxymethyl cellulose, sodium citrate, sodium starch glycolate, sorbitol, starch (corn), stearic acid, stearic acid, sucrose, talc, titanium dioxide, vitamin A, vitamin E, vitamin C, and xylitol. The formulations can be mixed with auxiliary agents which do not deleteriously react with the active compounds. Such additives can include wetting agents, emulsifying and suspending agents, salt for influencing osmotic pressure, buffers and / or coloring substances, preserving agents, sweetening agents, or flavoring agents. The compositions can also be sterilized if desired. The route of administration can be any route which effectively transports the active compound of the invention to the appropriate or desired site of action, such as oral, nasal, pulmonary, buccal, subdermal, intradermal, transdermal, or parenteral, including intravenous, subcutaneous and / or intramuscular. In one embodiment, the route of administration is oral. Dosage forms can be administered once a day, or more than once a day, such as twice or thrice daily. Alternatively, dosage forms can be administered less frequently than daily, such as every other day, or weekly, if found to be advisable by a prescribing physician or drug’s prescribing information. Dosing regimens include, for example, dose titration to the extent necessary or useful for the indication to be treated, thus allowing the patient’s body to adapt to the treatment, to minimize or avoid unwanted side effects associated with the treatment, and / or to maximize the therapeutic effect of the present compounds. Other dosage forms include delayed or controlled-release forms. Suitable dosage regimens and / or forms include those set out, for example, in the latest edition of the Physicians’ Desk Reference, incorporated herein by reference. In another embodiment, there are provided methods of making a composition of a compound described herein including formulating a compound of the invention with a pharmaceutically acceptable carrier or diluent. In some embodiments, the pharmaceutically acceptable carrier or diluent is suitable for oral administration. In some such embodiments, the methods can further include the step of formulating the composition into a tablet or capsule. In other embodiments, the pharmaceutically acceptable carrier or diluent is suitable for parenteral administration. In some such embodiments, the methods further include the step of lyophilizing the composition to form a lyophilized preparation. In another embodiment, a method of treating a subject having a neurodegenerative disease is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the neurodegenerative disease is a demyelinating disease. In another embodiment, the demyelinating disease is a chronic demyelinating disease. In yet another embodiment, the demyelinating disease is or is associated with a X-linked genetic disorder, leukodystrophy, dementia, tauopathy, or ischaemic stroke. In another embodiment, the demyelinating disease is or is associated with adult Refsum disease, Alexander disease, Alzheimer’s disease, Balo concentric sclerosis, Canavan disease, central pontine myelinolysis (CPM), cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy (CIDP), Devic's syndrome, diffuse myelinoclastic sclerosis, encephalomyelitis, idiopathic inflammatory demyelinating disease (IIDD), infantile Refsum disease, Krabbe disease, Leber hereditary optic neuropathy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy, multifocal motor neuropathy, paraproteinemic demyelinating polyneuropathy, Pelizaeus- Merzbacher disease, peroneal muscular atrophy, progressive multifocal leukoencephalopathy, transverse myelitis, tropical spastic paraparesis, van der Knaap disease, or Zellweger syndrome. In one embodiment, the demyelinating disease is or is associated with multiple sclerosis, MCT8 deficiency, X-linked adrenoleukodystrophy (ALD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, frontotemporal dementia, or lacunar stroke. As used herein, the term “neurodegenerative disease” refers to any type of disease that is characterized by the progressive deterioration of the nervous system. As used herein, the term “demyelinating disease” refers to any disease or medical condition of the nervous system in which myelin is damaged or lost, or in which the growth or development of the myelin sheath is impaired. Demyelination inhibits the conduction of signals in the affected nerves, causing impairment in sensation, movement, cognition, or other functions for which nerves are involved. Demyelinating diseases have a number of different causes and can be hereditary or acquired. In some cases, a demyelinating disease is caused by an infectious agent, an autoimmune response, a toxic agent or traumatic injury. In other cases, the cause of the demyelinating disease is unknown (“idiopathic”) or develops from a combination of factors. As used herein, the term “leukodystrophy” refers to a group of diseases that affects the growth or development of the myelin sheath. As used herein, the term “leukoencephalopathy” refers to any of a group of diseases affecting the white substance of the brain; can refer specifically to several diseases including, for example, “leukoencephalopathy with vanishing white matter” and “toxic leukoencephalopathy.” Leukoencephalopathies are leukodystrophy-like diseases. As used herein, the term “tauopathy” refers to tau-related disorders or conditions, e.g., Alzheimer's Disease (AD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Pick's Disease (PiD), Argyrophilic grain disease {AGD), Frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP-17), Parkinson's disease, stroke, traumatic brain injury, mild cognitive impairment and the like. As used herein, the terms “multiple sclerosis” and “MS” refer to a slowly progressive CNS disease characterized by disseminated patches of demyelination in the brain and spinal cord, resulting in multiple and varied neurological symptoms and signs, usually with remissions and exacerbation. The cause of MS is unknown but an immunological abnormality is suspected. An increased family incidence suggests genetic susceptibility, and women are somewhat more often affected than men. The symptoms of MS include weakness, lack of coordination, paresthesias, speech disturbances, and visual disturbances, most commonly double vision. More specific signs and symptoms depend on the location of the lesions and the severity and destructiveness of the inflammatory and sclerotic processes. Relapsing-remitting multiple sclerosis (RRMS) is a clinical course of MS that is characterized by clearly defined, acute attacks with full or partial recovery and no disease progression between attacks. Secondary-progressive multiple sclerosis (SPMS) is a clinical course of MS that initially is relapsing-remitting, and then becomes progressive at a variable rate, possibly with an occasional relapse and minor remission. Primary-progressive multiple sclerosis (PPMS) presents initially in the progressive form. A clinically isolated syndrome is the first neurologic episode, which is caused by inflammation / demyelination at one or more sites in the CNS. Progressive-relapsing multiple sclerosis (PRMS) is a rare form of MS (~5%) characterized by a steadily worsening disease state from onset, with acute relapses but no remissions. In yet another embodiment, a method of treating a subject having a X-linked genetic disorder is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the X-linked genetic disorder is MCTS deficiency or X-linked adrenoleukodystrophy (ALD). In another embodiment, a method of treating a subject having a leukodystrophy is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the leukodystrophy is adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN), cerebral form of adrenoleukodystrophy (cALD), metachromatic leukodystrophy (MLD), Canavan'’s disease, or Krabbe disease (globoid leukodystrophy). As used herein, the term “adrenomyeloneuropathy” or “AMN” refers to an adult variant of X-linked adrenoleukodystrophy, characterized by ABCD1 gene mutation, that results in impaired peroxisome function with accumulation of very long chain fatty acids (VLCFA) and demyelination. In one embodiment, a method of treating a subject having a tauopathy is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the tauopathy is Alzheimer’s disease, frontotemporal dementia, primary age-related tauopathy (PART), Pick’s disease, or frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). In yet another embodiment, a method of treating a subject having an ischaemic stroke is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the ischaemic stroke is lacunar stroke (also called “lacunar infarct”). In another embodiment, the present method is used to treat a subject suffering from a lacunar stroke syndrome {LACS). In another embodiment, a method of treating a subject having adult Refsum disease, infantile Refsum disease, Alexander disease, Alzheimer's disease, balo concentric sclerosis, Canavan disease, central pontine myelinolysis (CPM), cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy (CIDP), Devic's syndrome, diffuse myelinoclastic sclerosis, encephalomyelitis, idiopathic inflammatory demyelinating disease (IIDD), Krabbe disease, Leber hereditary optic neuropathy, leukodystrophy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy (MLD), multifocal motor neuropathy (MMN), multiple sclerosis (MS), paraproteinemic demyelinating polyneuropathy, Pelizaeus-Merzbacher disease (PMD), progressive multifocal leukoencephaalopathy (PML), tropical spastic paraparesis (TSP), X- linked adrenoleukodystrophy (X-ALD, ALO, or X-linked ALO), or Zellweger syndrome is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the demyelinating disease is multiple sclerosis. In another embodiment, the demyelinating disease is X-linked adrenoleukodystrophy (ALD). In another embodiment, a method of treating a subject having an amyotrophic lateral sclerosis (ALS) disease is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the ALS is sporadic or familial ALS, or ALS with Superoxide dismutase-1 mutation. In one embodiment, a method of treating a subject having a medical condition associated with increased activity of TGF-B is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In one embodiment, the medical condition associated with increased activity of TGF-B is a fibrotic disease. In another embodiment, the fibrotic disease is or is associated with nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF), systemic scleroderma, or Alport syndrome. As used herein, the term “Alport syndrome” refers to a hereditary disorder caused by mutations in the a3a4a5(IV) collagen network genes resulting in structural defects in the glomerular basement membrane (GBM) early during development leading subsequently to the breakdown of the filtration barrier, development of renal fibrosis and kidney failure. As used herein, the term “fibrotic disease” refers to a condition, disease or disorder that is amenable to treatment by administration of a compound having anti-fibrotic activity. Fibrotic diseases include, but are not limited to, pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and pulmonary fibrosis from a known etiology, liver fibrosis, and renal-fibrosis. Other exemplary fibrotic diseases include musculoskeletal fibrosis, cardiac fibrosis, post-surgical adhesions, scleroderma, glaucoma, and skin lesions such as keloids. In another embodiment, a method of treating a subject having NASH, NAFLD, NAFLD with hyperlipidemia, alcoholic liver disease / alcoholic steatohepatitis, liver fibrosis associated with viral infection (HBV, HCV), fibrosis associated with cholestatic diseases (primary biliary cholangitis, primary sclerosing cholangitis), (familial) hypercholesterolemia, dyslipidemia, genetic lipid disorders, cirrhosis, alcohol-induced fibrosis, hemochromatosis, glycogen storage diseases, alpha-1 antitrypsin deficiency, autoimmune hepatitis, Wilson’s disease, Crigler-Najjar Syndrome, lysosomal acid lipase deficiency, liver disease in cystic fibrosis is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having Alport syndrome, diabetic nephropathy, FSGS, fibrosis associated with IgA nephropathy, chronic kidney diseases (CKD), post AKI, HIV associated CKD, chemotherapy induced CKD, CKD associated with nephrotoxic agents, nephrogenic systemic fibrosis, tubulointerstitial fibrosis, glomerulosclerosis, or polycystic kidney disease (PKD) is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having IPF, ILD, pulmonary fibrosis, pulmonary fibrosis associated with autoimmune diseases like rheumatoid arthritis, scleroderma or Sjogren's syndrome, asthma-related pulmonary fibrosis, COPD, asbestos or silica induced PF, silicosis, respiratory bronchiolitis, Idiopathic interstitial pneumonias (IIP), Idiopathic nonspecific interstitial pneumonia, Respiratory bronchiolitis- interstitial lung disease, desquamative interstitial pneumonia, acute interstitial pneumonia, Rare IIPs: Idiopathic lymphoid interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, unclassifiable idiopathic interstitial pneumonias, hypersensitivity pneumonitis, radiation-induced lung injury, progressive massive fibrosis — pneumoconiosis, bronchiectasis, byssinosis, chronic respiratory disease, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary arterial hypertension (PAH), or Cystic fibrosis is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having scleroderma / systemic sclerosis, graft versus host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutanea tarda, restrictive dermopathy, Dupuytren’s contracture, dermal fibrosis, nephrogenic systemic fibrosis / nephrogenic fibrosing dermopathy, mixed connective tissue disease, scleromyxedema, eosinophilic fasciitis, fibrosis caused by exposure to chemicals or physical agents. GvHD induced fibrosis, Scleredema adultorum, Lipodermatosclerosis, or Progeroid disorders (progeria, acrogeria, Werner's syndrome) is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having atrial fibrosis, endomyocardial fibrosis, cardiac fibrosis, atherosclerosis, restenosis, or arthrofibrosis is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having mediastinal fibrosis, myelofibrosis, post-polycythermia vera myelofibrosis, or post essential thrombocythemia is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having Crohn's disease, retroperitoneal fibrosis, intestinal fibrosis, fibrosis in inflammatory bowel disease, ulcerative colitis, Gl fibrosis due to cystic fibrosis, or pancreatic fibrosis due to pancreatitis is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having endometrial fibrosis, uterine fibroids, or Peyronie's disease is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having macular degeneration, diabetic retinopathy, retinal fibrovascular diseases, or vitreal retinopathy is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (I) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. In another embodiment, a method of treating a subject having scarring associated with trauma (surgical complications, chemotherapeutics drug-induced fibrosis, radiation induced fibrosis) is provided, the method comprising administering to the subject a pharmaceutically effective amount of a compound having the structure of Formula (1) or pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof, or a pharmaceutical composition thereof. As used herein, the term “administration” refers to providing a compound, a prodrug of a compound, or a pharmaceutical composition comprising the compound or prodrug as described herein. The compound or composition can be administered by another person to the subject or it can be self-administered by the subject. Non-limiting examples of routes of administration are oral, parenteral {e.g., intravenous), or topical. As used herein, the term “treatment” refers to an intervention that ameliorates a sign or symptom of a disease or pathological condition. As used herein, the terms “treatment”, “treat” and "treating," with reference to a disease, pathological condition or symptom, also refers to any observable beneficial effect of the treatment. The beneficial effect can be evidenced, for example, by a delayed onset of clinical symptoms of the disease in a susceptible subject, a reduction in severity of some or all clinical symptoms of the disease, a slower progression of the disease, a reduction in the number of relapses of the disease, an improvement in the overall health or well-being of the subject, or by other parameters well known in the art that are specific to the particular disease. A prophylactic treatment is a treatment administered to a subject who does not exhibit signs of a disease or exhibits only early signs, for the purpose of decreasing the risk of developing pathology. A therapeutic treatment is a treatment administered to a subject after signs and symptoms of the disease have developed. As used herein, the term “subject” refers to an animal (e.g., a mammal, such as a human). A subject to be treated according to the methods described herein may be one who has been diagnosed with a neurodegenerative disease involving demyelination, insufficient myelination, or underdevelopment of a myelin sheath, e.g., a subject diagnosed with multiple sclerosis or cerebral palsy, or one at risk of developing the condition. Diagnosis may be performed by any method or technique known in the art. One skilled in the art will understand that a subject to be treated according to the present disclosure may have been subjected to standard tests or may have been identified, without examination, as one at risk due to the presence of one or more risk factors associated with the disease or condition. As used herein, the term “effective amount” refers to a quantity of a specified agent sufficient to achieve a desired effect in a subject being treated with that agent. Ideally, an effective amount of an agent is an amount sufficient to inhibit or treat the disease without causing substantial toxicity in the subject. The effective amount of an agent will be dependent on the subject being treated, the severity of the affliction, and the manner of administration of the pharmaceutical composition. Methods of determining an effective amount of the disclosed compound sufficient to achieve a desired effect in a subject will be understood by those of skill in the art in light of this disclosure. As used herein, the terms “chronic” refers to a medical disorder or condition that persists over time or is frequently recurring. Compounds having the structure of Formulas (1), (11), (111), (IV), (V), (VI), (VIl) and (VII) can be synthesized using standard synthetic techniques known to those skilled in the art. For example, compounds of the present invention can be synthesized using appropriately modified synthetic procedures set forth in WO 2014 / 178892, WO 2014 / 178931, WO 2016 / 134292, WO 2017 / 201320, WO 2018 / 032012, and Schemes 1-7 below. To this end, the reactions, processes, and synthetic methods described herein are not limited to the specific conditions described in the following experimental section, but rather are intended as a guide to one with suitable skill in this field. For example, reactions may be carried out in any suitable solvent, or other reagents to perform the transformation[s] necessary. Generally, suitable solvents are protic or aprotic solvents which are substantially non-reactive with the reactants, the intermediates or products at the temperatures at which the reactions are carried out (i.e., temperatures which may range from the freezing to boiling temperatures, or higher if reactions are run in sealed vessels). A given reaction may be carried out in one solvent or a mixture of more than one solvent. Depending on the particular reaction, suitable solvents for a particular work-up following the reaction may be employed. Rr? )§ Hi S0Cl, ih SN? E Lewis acid 2 x! “5 @ IX ’ wa XE~F oo Orie 0 x? . 0, o ® c D F Compounds of the present invention can be prepared according to Scheme 1. Referring to Scheme 1, a di- or tri-substituted phenol (A) (for example, 3,5-dichlorophenol or 3-methyl-5-chlorophenol or 3,5-dichloro-2-fluoro-phenol, or the like) is reacted with a formaldehyde equivalent (for example, aqueous formaldehyde or paraformaldehyde or dimethoxymethane or the like) to give a hydroxymethyl derivative (B), which is subsequently reacted with an activated acetate moiety {for example ethyl chloroacetate or methyl bromoacetate or the like) in the presence of base, selectively at the phenolic oxygen, to provide intermediate (C). The hydroxymethyl group is activated (for example, through reaction with thionyl chloride or oxalyl chloride or p-toluenesulfonylchloride or the like) to give a chloromethyl derivative (D) {or the corresponding tosylate, or mesylate, or bromomethyl analog, or the like), which is condensed with a 2-substituted phenol (E) in the presence of a Lewis acid (like zinc chloride, or aluminum chloride, or the like) to give an ester (F). Alternatively intermediate alcohol (C) can be reacted directly with phenol (E) in the presence of a protic acid like sulfuric acid or the like, or a Lewis acid like boron trifluoride etherate or the like. Scheme 2. R2.X y2 x! R2-X y2 x! HO XEN 0 ORT Lewssacd HO x2 oR" 0 G F Compounds of the present invention can be prepared according to Scheme 2. Referring to Scheme 2, phenol G (=F, R*=H; prepared according to Scheme 1) is then reacted with a reactive halide H, for example p-fluorobenzyl chloride or 1-(1-chloroethyl)-4-fluoro- benzene or 2,4-difluorobenzyl alcohol or the like, in the presence of a Lewis acid like Zinc chloride or Aluminum chloride or boron trifluoride etherate or the like, to give a 3’-alkylated product like ester F. Scheme 3. Y? x! Y? x! oC nol HO x? 0 OR® HO x? oY OR 0 0 G R2-B(OR), J ¥2 x! R%-B(OR), ¥2 x! | xy! J R? xy! J 1 O10 . ® 1 O.n 1c HO X oY UR Pd(ll) HO x 0 R 0 0 K Compounds of the present invention can be prepared according to Scheme 3. Referring to Scheme 3, ortho-iodination of phenol G, for example using N-iodosuccinimide or solid iodine or the like, provides key intermediate I. To prepare compounds of the present invention, | is reacted with a boronic acid (or boronate) J under various Suzuki conditions to provide esters K of the present invention. Scheme 4. hydrolysis Y? x! Y? x! R2 xy! hydrolysis R2 x! (Lo > J HO XE Po Ore HO x2 ~~ OH N lo 0 K heat R12R1E.NH activating agent NS Y? xX! “CY Ra R HO » oR 0 As shown in Scheme 4, hydrolysis of the ester group of (K), for example using aqueous sodium hydroxide {if R! is methyl) or TFA {if R* is t-butyl) provides acids (L) of the present invention. If desired, acid (L) can be converted to an amide {M) by condensing with the corresponding amine {for example methylamine or propylamine or 2-sulfonylethylamine or the like) in the presence of a coupling agent like DDC or EDCI or the like, or by forming an activated intermediate (for example the corresponding acid chloride) using thionyl chloride or the like. Alternatively, if desired, either esters (K), or acids (L) may be heated with an amine RIPRINH, for example methylamine or propylamine or 2-sulfonylethylamine or the like, to give amides (M) of the present invention. Scheme 5. (RO),B-B(OR)> or (RO),B-X AY! [01 ——— IN | — Nie Ae x! or x! x! y (RORB-X lod [0] ox an —_— 7 Ir(l) x? B(OR); x? OH N o A Phenols (A) of the present invention may be commercially available, or may be prepared according to Scheme 5. Referring to Scheme 5, di- or -tri-substituted arenes (N) may be oxidatively borolated using an activated borylating agent like {(bis-pinacolato)diboron or the like, in the presence of an active metal catalyst like (1,5-cyclooctadiene)(methoxy)iridium(l) dimer or the like, to give the corresponding boronate (0). Oxidative deborylation of O, for example using hydrogen peroxide solution, provides the corresponding phenol (A). Scheme 6. X'-B(OR), AY! [H] — Pd catalyst Bril C X2 OH x x2 y! ‘OH my x! LX y! ‘OH P A A An alternative approach to the preparation of key intermediate phenols (A) is described in Scheme 6. Referring to Scheme 6, di- or tri-substituted phenols (P) having one substituent as bromine or iodine may be reacted under Suzuki coupling conditions, for example using a boronic acid or boronate reagent or the like, in the presence of a Palladium catalyst like Pd{OAc), or Pd{dppf)Cl; or the like, to produce alkyl, alkenyl, or alkynyl products (A). In the case where X! is an alkene or alkyne, subsequent hydrogenation, for example using Pd-C catalyst under a hydrogen atmosphere, can provide the corresponding alkyl-substituted (A). Scheme 7. J Pd catalyst Y? R2-B(OR), , Y? "0 rm SO HO Pd catalyst HO Q E — = | | —— 2) Ye AY? AY? OM TO "0 — — HO 2) A HO HO ) A IN Q BV S E Substituted phenols (E) as employed in Scheme 3 may be prepared as indicated in Scheme 7. Referring to Scheme 7, a 2-halophenol {Q) like 2-bromophenol or 2- bromo-3-fluorophenol or the like may be condensed with a boronic acid or ester (J) under Suzuki conditions in the presence of a palladium catalyst or the like, to give 2-substituted phenol (E). In the case where the R? group is an alkene or alkyne, subsequent hydrogenation, for example using Pd-C catalyst under a hydrogen atmosphere, can provide the corresponding alkyl-substituted phenl (E). Alternatively a 2-halophenol (Q) like 2-bromophenol or 2-bromo-3- fluorophenol or the like may be metallated using isopropylmagnesium bromide or n- butyllithium or the like, then condensed with an aldehyde or ketone (R), to give an intermediate like {S). Deoxygenation of (S) under hydrogenolysis conditions, using hydrogen gas in the presence of a palladium or platinum catalyst or the like, or under reductive- deoxygenation conditions in the presence of a reducing agent triethylsilane or the like, in the presence of an acid like TFA or the like, produces substituted phenol (E). Scheme 8. R2 R2 {RO);B-B(OR), — He xX Pd no X A, on ) OR J R2 Co R2 1) R-M — He xX 2) B(OR), ne 2 RIS gor . OR J Arylboronic acids or esters (J) as employed in Scheme 3 may be sourced commercially, or may be prepared as described in Scheme 8. Referring to Scheme 8, aryl halides (T) may be reacted with di(pinacolato)diboron or a similar reagent, using a palladium catalyst or the like, to give (J). Alternatively (T) may be metallated using isopropylmagnesium bromide or n-butyllithium or the like, then reacted with a trialkoxyborate or the like, to provide (J). EXAMPLES The invention is further illustrated by the following examples. The examples below are non-limiting are merely representative of various aspects of the invention. Solid and dotted wedges within the structures herein disclosed illustrate relative stereochemistry, with absolute stereochemistry depicted only when specifically stated or delineated. General Methods All reagents, for which the synthesis is not described in the experimental part, are either commercially available, or are known compounds or may be formed from known compounds by known methods by a person skilled in the art. The compounds and intermediates produced according to the methods of the invention may require purification. Purification of organic compounds is well known to a person skilled in the art and there may be several ways of purifying the same compound. In some cases, no purification may be necessary. In some cases, the compounds may be purified by crystallization. In some cases, impurities may be stirred out using a suitable solvent. In some cases, the compounds may be purified by chromatography, particularly flash column chromatography, using purpose-made or prepacked silica gel cartridges and eluents such as gradients of solvents such as heptane, ether, ethyl acetate, acetonitrile, ethanol and the like. In some cases, the compounds may be purified by preparative HPLC (normal-phase or reversed-phase) using methods as described. Preparative HPLC purification by reverse phase HPLC was performed using gradients of acetonitrile in aqueous TFA or an equivalent HPLC system such as Methanol in aqueous ammonium acetate. Purification methods as described herein may provide compounds of the present invention which possess a sufficiently basic or acidic functionality in the form of a salt, such as, in the case of a compound of the present invention which is sufficiently basic, a trifluoroacetate or formate salt, or, in the case of a compound of the present invention which is sufficiently acidic, an ammonium salt. A salt of this type can either be transformed into its free base or free acid form, respectively, by various methods known to a person skilled in the art, or be used as salts in subsequent biological assays. It is to be understood that the specific form of a compound of the present invention as isolated and as described herein is not necessarily the only form in which said compound can be applied to a biological assay in order to quantify the specific biological activity. All the starting materials and reagents are commercially available and were used as is. *H Nuclear magnetic resonance (NMR) spectroscopy was carried out using a Bruker instrument operating at 400 MHz using the stated solvent at around room temperature unless otherwise stated. In all cases, NMR data were consistent with the proposed structures. Characteristic chemical shifts (8) are given in parts-per-million using conventional abbreviations for designation of major peaks: e.g. s, singlet; d, doublet; t, triplet; q, quartet; dd, doublet of doublets; dt, doublet of triplets; m, multiplet; br, broad. Chemical names were generated using the ChemDraw naming software (Version 17.0.0.206) by PerkinElmer Informatics, Inc. In some cases, generally accepted names and generally accepted acronyms for commercially available reagents were used in place of names generated by the naming software. INTERMEDIATE Al Synthesis of methyl 2-{4-formyl-3,5-dimethylphenoxy)acetate (Intermediate Al “1, 0 NOS 0 Al To a solution of 2,6-dimethyl-4-hydroxybenzaldehyde (5.0 g, 33.3 mmol) in acetone (50 mL) were added methyl chloroacetate (3.9 g, 36.6 mmol), Nal {1.1 g, 6.66 mmol) and Cs,C03(11.0 g, 33.3 mmol). The mixture was stirred at 55°C for 5h. Water (200 mL) was added and the mixture was extracted with EtOAc {50 mL*3). The combined organic layer was washed with brine (100 mL), dried over Na,SO, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=4:1) to afford Intermediate Al (7.1 g, 96.0% yield) as a yellow solid. TLC: Pet. ether / EtOAc=3 / 1(v / v), Rf=0.5 LCMS: RT=3.177 min, [M+1]= 223.0 IH NMR: {400 MHz, DMSO-d6) § 10.34 (s, 1 H), 6.70 {s, 2 H), 4.85 (s, 2 H), 3.67(s, 3 H). INTERMEDIATE A2 Synthesis of methyl 2-(4-(hydroxymethyl)-3,5-dimethylphenoxy)acetate (Intermediate A2 “CL 0. oY ~ 0 A2 To a mixture of Intermediate Al (6.9 g, 31.1 mmol) in MeOH (50 mL) at 0°C was added NaBHz (1.2 g, 31.1 mmol). The mixture was stirred at rt for 2h. Water (50 mL) was added, and the mixture was extracted with EtOAc (20 mL*2). The organic layer was washed with brine (20 mL), dried over Na,SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (Pet. ether / EtOAc=3:1) to afford Intermediate A2 (5.8 g) as a white solid. TLC: Pet. ether / EtOAc=3 / 1(v / v), Rf=0.3 1H NMR: {400 MHz, DMSO-d6) 8 6.56 {s, 2 H), 4.73 (s, 2 H), 4.59 (t, }=8.0, 1 H), 4.39(d, J=7.6 Hz, 2 H), 3.68 (s, 3 H), 2.30 (s, 6 H). INTERMEDIATE A3 Synthesis of methyl 2-(4-(chloromethyl)-3,5-dimethylphenoxy)acetate (Intermediate A3 © pon 0 A3 To a solution of Intermediate A2 (5.8 g, 25.9 mmol) in DCM (50 mL) at 0°C was added SOCI; (9.2 g, 77.6 mmol) dropwise. The mixture was stirred at rt for 2h. The mixture was concentrated in vacuo and the product was washed with n-hexane (50 mL) to afford Intermediate A3 (5.3 g, 84.4% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1(v / v), Rf=0.6 1H NMR: (400 MHz, DMSQ-d6) 6 6.65 (s, 2 H), 4.77 (s, 2 H), 4.75 (s, 2 H), 3.69 (5, 3 H), 2.33(s, 6 H), INTERMEDIATE A4 Synthesis of 3-bromo-4-(hydroxymethyl)-5-methylphenol (Intermediate A4) Br Br 7 OH Ad To a solution of sodium hydroxide (1.76 g, 44.1 mmol) in water (30 mL) was added 3-bromo-5-methyl-phenol (7.5 g, 40.1 mmol). The solution was heated to 45°C, and formaldehyde (3.25 g, 40.1 mmol, 37% / w in water) was added dropwise. The mixture was stirred at 45°C for 2h. The mixture was cooled, and water (10 mL) was added. The mixture was acidified with HCl (3N) to pH~3. The mixture was extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na,SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (pet. ether:EtOAc=30:1 to 4:1) to afford Intermediate Ad (1.0 g, 4.6 mmol, 11.5% yield) as a white solid. TLC: Pet. ether / EtOAc=1 / 1(v / v), Rf=0.8 1H NMR: (400 MHz, DMSO-d) § 9.67 (s, 1H), 6.80 (d, J = 2.4 Hz, 1H), 6.60 (d, J = 2.5 Hz, 1H), 4.73 (t, J = 5.1 Hz, 1H), 4.51 {d, J = 5.1 Hz, 2H), 2.33 (s, 3H). INTERMEDIATE AS Synthesis of ethyl 2-(3-bromo-4-(hydroxymethyl)-5-methylphenoxy)acetate (Intermediate AS! Br “CL Oo oY oO AS To a solution of Intermediate A4 {1.0 g, 4.6 mmol) and sodium bicarbonate (657 mg, 7.8 mmol) in DMF {10 mL) at rt was added ethyl 2-bromoacetate (1.0 g, 6.0 mmol). The mixture was stirred at rt overnight. Water (20 mL) was added, and the mixture was extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na;SOs, and concentrated in vacuo. The residue was purified by silica gel column chromatography (pet. ether: EtOAc=100:1 to 5:1) to afford Intermediate AS (600 mg, 42% yield) as a white solid. TLC: Pet. ether / EtOAc=2 / 1(v / v), Rf=0.7 1H NMR: {400 MHz, DMSO-d) 6 6.99 (d, J = 2.8 Hz, 1H), 6.83 — 6.80 (m, 1H), 4.85 (t, J = 5.2 Hz, 1H), 4.79 (s, 2H), 4.55 (d, J = 5.2 Hz, 2H), 4.17 (q, J = 7.2 Hz, 2H), 2.38 (s, 3H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A6 Synthesis of ethyl 2-(3-bromo-4-(chloromethyl)-5-methylphenoxy)acetate (Intermediate A6 Br I OL ~ oY 0 AB To a solution of Intermediate A5 (600 mg, 1.98 mmol) in dichloromethane (10 mL) at rt was added thionyl chloride (471 mg, 3.96 mmol). The mixture was stirred at rt for 1h, then concentrated in vacuo to afford Intermediate A6 (600 mg, 94% yield) as a white solid. TLC: Pet. ether / EtOAc=2 / 1(v / v), Rf=0.8 1H NMR: (400 MHz, DMSO-ds) § 7.10 (d, J = 2.8 Hz, 1H), 6.92 — 6.89 {m, 1H), 4.84 (s, 4H), 4.17 (gq, J =7.2 Hz, 2H), 2.42 (s, 3H), 1.21 {t, J = 7.2 Hz, 3H). INTERMEDIATE A7 Synthesis of 3,5-dichloro-4-(hydroxymethyl)phenol {Intermediate AZ Cl 7. Cl OH AT To a solution of NaOH (6.7g, 169 mmol) in water (20 mL) was added 3,5- dichlorophenol (25.0 g, 153 mmol). The mixture was heated to 45°C and 36% aqueous formaldehyde (12.4 g, 153 mmol) was added dropwise slowly. The mixture was stirred at 45°C for 2h, then cooled to rt. The pH was adjusted to 3-4 with 1N HCl, and the mixture was stirred at rt for 20 min. The solid was filtered, washed with water (50 mL) and dried to afford Intermediate A7 (11.5 g, 59.6 mmol, 39% yield) as an off-white solid. TLC: EtOAc / pet. ether 1 / 3, Rf 0.36 1H NMR: (400 MHz, DMSO-ds) § 10.02 {s, 1H), 6.82 (s, 2H), 4.98 (s, 1H), 4.57 (d, J=2.1 Hz, 2H) INTERMEDIATE A8 Synthesis of methyl 2-(3,5-dichloro-4-(hydroxymethyl)phenoxy)acetate {Intermediate A8! Cl wl “0 o cl oY ~ oO AB To a solution of Intermediate A7 (3.0 g, 15.5 mmol) in acetone {40 mL) were added potassium carbonate (3.22 g, 23.3 mmol) and methyl 2-chloroacetate (2.02 g, 18.6 mmol). The mixture was refluxed for 2h. The mixture was cooled to rt, diluted with water (120 mL), and extracted with EtOAc (80 mL*3). The combined organic phase was washed with brine (200 mL), dried over Na;SOs, and concentrated in vacuo. The residue was purified by silica gel column chromatography (pet. ether / EtOAc=20 / 1 to 5 / 1) to afford Intermediate A8 (2.0 g, 7.54 mmol, 48.5% yield) as a white solid. TLC: EtOAc / pet. ether 1 / 5, Rf 0.28 1H NMR: {400 MHz, DMSO-ds) 6 7.10 (s, 2H), 5.08 (t, / = 5.3 Hz, 1H), 4.91 (s, 2H), 4.61 (d, J=5.3 Hz, 2H), 3.70 {s, 3H). INTERMEDIATE A9 Synthesis of ethyl 2-(3,5-dichloro-4-(hydroxymethyl)phenoxy)acetate (Intermediate AS Cl wl gol cl oN ON oO To a solution of Intermediate A7 (13.0 g, 67.4 mmol) in DMF (120 mL) at rt were added ethyl 2-bromoacetate (11.25 g, 67.4 mmol) and K,COs (11.2 g, 80.8 mmol). The mixture was stirred at rt for 2h, diluted with water (200 mL), and extracted with EtOAc (100 mL*3). The combined organic phase was washed with water (100 mL*3) and brine (200 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=5 / 1) to afford Intermediate AS (15 g, 79% yield) as an off-white solid. TLC: EtOAc / pet. ether =1 / 5 {v / v}, Rf=0.42 1H NMR: (400 MHz, DMSO-ds) § 7.09 (s, 2H), 5.09 (t, J = 5.2 Hz, 1H), 4.88 (s, 2H), 4.60 (d, J=5.2 Hz, 2H), 4.17 {q, J = 7.1 Hz, 2H), 1.21 (t, J = 7.1 Hz, 3H). INTERMEDIATE A10 Synthesis of methyl 2-(3,5-dichloro-4-(chloromethyl}phenoxy)acetate {Intermediate A10 Cl wl cl ou cl oY oO A110 To a mixture of Intermediate A8 (1.0 g, 3.77 mmol) in DCM (10 mL) was added thionyl chloride (0.67g, 5.66 mmol). The mixture was stirred at rt for 1h, then was concentrated in vacuo to afford crude Intermediate A10 (1.0 g, 3.53 mmol, 93.5% yield) as a light yellow solid. TLC: EtOAc / pet. ether 1 / 5, Rf 0.72 1H NMR: (400 MHz, DMSO-ds) § 7.21 (s, 2H), 4.94 (s, 2H), 4.85 (s, 2H), 3.71 (s, 3H). INTERMEDIATE A11 Synthesis of ethyl 2-(3,5-dichloro-4-(chloromethyl)phenoxy)acetate {Intermediate A11 Cl ol “1. cl oN ON oO AM To a reaction mixture of Intermediate AS (15.0 g, 3.77 mmol) in DCM (150 mL) at 0°C was added dropwise thionyl chloride (9.59 g, 80.6 mmol). The mixture was stirred at rt for 1h, diluted with DCM (100 mL), and concentrated in vacuo to afford Intermediate A11 (15.0 g, 93.5% yield) as a light yellow solid. TLC: EtOAc / pet. ether =1 / 5 {v / v), Rf=0.72 1H NMR: (400 MHz, DMSO-d) § 7.20 (s, 2H), 4.92 (s, 2H), 4.86 (s, 2H), 4.17 (q, J = 7.2 Hz, 2H), 1.21 (t, f= 7.1 Hz, 3H). INTERMEDIATE A12 Synthesis of 3-chloro-4-(hydroxymethyl}-5-methylphenol {Intermediate A12 Cl Al pel OH Al12 To a mixture of 3-chloro-5-methyl-phenol (3.55 g, 24.9 mmol) in water (10 mL) at rt was added NaOH (1.10 g, 27.42 mmol). The mixture was heated to 45°C, and formaldehyde (0.75 g, 24.93 mmol, 37% / w in water) was added dropwise. The mixture was stirred at 45°C for 2h. The mixture was cooled to rt, then acidified with HCI (3N) to pH~3, and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (15 mL), dried over Na;S04, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=50 / 1 to 5 / 1) to afford Intermediate A12 (0.76 g, 4.40 mmol, 17.7% yield) as an off-white solid. TLC: EtOAc / pet. ether =1 / 1{v / v), Rf=0.8 1H NMR: (400 MHz, DMSO-d) § 9.68 (s, 1H), 6.62 (d, J = 2.4 Hz, 1H), 6.56 (d, J = 2.4 Hz, 1H), 4.73 (t, J = 5.2 Hz, 1H), 4.49 {d, J = 5.2 Hz, 2H), 2.31 (s, 3H). INTERMEDIATE A13 Synthesis of ethyl 2-(3-chloro-4-(hydroxymethyl}-5-methylphenoxy)acetate Intermediate A13 Cl “3. oO ~ 0 A13 To a solution of Intermediate A12 {1.00 g, 5.79 mmol) in DMF (10 mL) at rt were added K,CO; (0.97 g, 6.95 mmol), and ethyl bromoacetate (0.98 g, 5.79 mmol). The mixture was stirred at rt for 4h, then diluted with water (30 mL) and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na;SOs, and concentrated in vacuo to afford Intermediate A13 (1.2 g, 75.9 % yield). TLC: EtOAc / pet. ether =1 / 2{v / v), Rf=0.54 INTERMEDIATE A14 Synthesis of ethyl 2-(3-chloro-4-(chloromethyl}-5-methylphenoxylacetate {Intermediate A14] Cl “XX ot Br nN oO To a solution of Intermediate A13 (1.00 g, 3.87 mmol) in DCM (10 mL) at rt was added SOCI; (0.55 g, 4.64 mmol). The mixture was stirred at rt for 2h, then concentrated in vacuo to afford Intermediate A14 (1.0 g, 93.4% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 10 {v / v}, Rf=0.67 1H NMR: (400 MHz, DMSO-d) § 6.95 (d, J = 2.6 Hz, 1H), 6.86 (d, J = 2.6 Hz, 1H), 4.82 (d, J =5.3 Hz, 4H), 4.16 (q, J = 7.0 Hz, 2H), 2.39 (s, 2H), 1.20 (t, J = 7.2 Hz, 3H). INTERMEDIATE A15 Synthesis of 3-bromo-5-chloro-4-(hydroxymethyl)phenol {Intermediate A15 Br -y Cl OH A115 To a solution of NaOH (463 mg, 11.6 mmol) in water (20 mL) at rt was added 3-chloro-5-bromophenol (2.4 g, 11.6 mmol). The mixture was heated to 45°C, and formaldehyde (347 mg, 11.6 mmol) was added dropwise. The mixture was stirred overnight at 45 °C, then diluted with water (20 mL), acidified with 1N HCl to pH~6-7, and extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine {30 mL), dried over Na;SO4, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=100 / 1 to 5 / 1) to afford Intermediate A15 (850 mg, 31% yield) as a white solid. TLC: Pet. ether / EtOAc= 3 / 1{v / v), Rf= 0.35. LCMS: RT= 1.619 min, [M-1] = 234.9, INTERMEDIATE A16 Synthesis of ethyl 2-(3-bromo-5-chloro-4-(hydroxymethyl)phenoxy)acetate (Intermediate A16' Br or “1 cl oY Dg 0 A186 To a solution of Intermediate A15 (850 mg, 3.58 mmol) in DMF (10 mL) at rt were added K,COs (742 mg, 5.37 mmol) and ethyl bromoacetate (717 mg, 4.30 mmol); the mixture was stirred at rt for 2h. Water (30mL) was added and the resultant mixture was extracted with EtOAc (30 mL*2). The combined organic phase was washed with water (20 mL*3) and brine {30 mL*3), dried over Na,50, and concentrated in vacuo to afford Intermediate A16 (920 mg, 79 % yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1(v / v), Rf=0.51 IH NMR: {400 MHz, DMSO-ds) 6 7.23 (d, J = 2.8 Hz, 1H), 7.13 (d, J = 2.4 Hz, 1H), 5.07 (t, J =5.2 Hz, 1H), 4.88 (s, 2H), 4.63 (d, J = 5.2 Hz, 2H), 4.17 {(g, J = 7.2 Hz, 2H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A17 Synthesis of ethyl 2-(3-bromo-5-chloro-4-{chloromethyliphenoxy)acetate {Intermediate A17 Br or “OL. cl eNO oO A17 To a solution of Intermediate A16 (500 mg, 1.55 mmol) in DCM (7 mL) at 0°C was added SOCI; (276 mg, 2.32 mmol). The mixture was stirred at rt for 2h, then concentrated in vacuo to afford crude Intermediate A17 {500 mg, 94.6 % yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1(v / v), Rf=0.79 1H NMR: (400 MHz, DMSO-ds) § 7.34 (d, J = 2.4 Hz, 1H), 7.24 (d, J = 2.4 Hz, 1H), 4.92 (s, 2H), 4.88 (s, 2H), 4.17 {q, J = 7.2 Hz, 2H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A18 Synthesis of 4-bromo-2-fluoro-3,5-dimethylphenol {Intermediate A18 OH A118 To a solution of 4-bromo-3,5-dimethylphenol (20 g, 99.5 mmol) in DCE (200 mL) at rt was added N-Fluoropyridinium triflate (24.6 g, 99.5 mmol); the resultant solution was heated to 80°C overnight. The reaction was cooled to rt, diluted with EtOAc (1000 mL), and filtered. The filtrate was washed with water (400 mL*3), and brine (400 mL*2), dried over Naz50., and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 50) to afford Intermediate A18 (6.0 g, 27.5% yield) as a yellow solid. TLC: EtOAc / pet. ether=1 / 10, Rf=0.45 1H NMR: (400 MHz, DMSO-d) 5 9.88 (d, J = 1.2 Hz, 1H), 6.81 (d, J = 9.2 Hz, 1H), 2.24 (d, J =3.2 Hz, 6H). 19F NMR: {376 MHz, DMSO-d;) 6 -137.26. INTERMEDIATE A19 Synthesis of 1-(benzyloxy)-4-bromo-2-fluoro-3,5-dimethylbenzene (Intermediate A19' oy A19 To a solution of Intermediate A18 (6.0 g, 27.4 mmol) in DMF (35 mL) at rt were added benzyl bromide (5.2 g, 30.1 mmol) and Cs,CO; (17.9 g, 54.8 mmol); the resultant mixture was stirred overnight at rt. The reaction mixture was diluted with EtOAc (300 mL) and filtered. The filtrate was washed with water (100 mL*2), then brine (100 mL*2), dried over Na,S04, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100) to afford Intermediate A19 (6.6 g, 77.9% yield) as a white solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.78 1H NMR: (400 MHz, DMSO-d) &§ 7.57 — 7.30 {m, 5H), 7.20 (d, J = 8.9 Hz, 1H), 5.16 (s, 2H), 2.31(s, 3H), 2.27 (d, J = 2.8 Hz, 3H). 19F NMR: {376 MHz, DMSO-d) 5 -135.63. INTERMEDIATE A20 Synthesis of 4-(benzyloxy}-3-fluoro-2,6-dimethylbenzaldehyde (Intermediate A20] Xs To a solution of Intermediate A193 (6.6 g, 21.3 mmol) in THF (70 mL) at -60°C was added dropwise n-BuLi (23.5 mmol, 9.4 mL of 2.5M). The resultant mixture was stirred for 1h at -60°C, then DMF (3.1 g, 42.7 mmol) was added. The reaction was stirred at -60°C for 1h, then quenched with water (100 mL) and extracted with EtOAc {100 mL*2). The combined organic phase was washed with brine (100 mL*2), dried over Na,SOs, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 10) to afford Intermediate A20 (4.1 g, 74.3% yield) as a white solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.65 1H NMR: (400 MHz, DMSO-ds) § 10.34 {d, J = 1.2 Hz, 1H), 7.60 — 7.28 (m, 5H), 7.10 (d, J = 8.0 Hz, 1H), 5.26 (s, 2H), 2.54 (s, 3H), 2.45 (d, J = 2.4 Hz, 3H). 19F NMR: (376 MHz, DMSO-ds) 6 -142.02. INTERMEDIATE A21 Synthesis of 3-fluoro-4-hydroxy-2,6-dimethylbenzaldehyde (Intermediate A21 0 pod OH A21 To a solution of Intermediate A20 (4.1 g, 15.9 mmol) in THF (60 mL) at rt was added Pd / C (600 mg (5% w / w), 0.28 mmol). The flask was degassed and flushed three times with with Hz (g), then stirred for 1.5 h. The reaction mixture was filtered; the filtrate was concentrated in vacuo. The crude product was recrystallized from hexane (5 mL) to afford Intermediate A21 (2.4 g, 89.9% yield) as a white solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.35 IH NMR: {400 MHz, DMSO-ds) § 10.78 (s, 1H), 10.29 (d, J = 0.8 Hz, 1H), 6.69 (d, / = 8.4 Hz, 1H), 2.47 (s, 3H), 2.44 (d, J = 2.4 Hz, 3H). 19 NMR: (376 MHz, DMSO-d) § -143.64. INTERMEDIATE A22 Synthesis of 2-fluoro-4-(hydroxymethyl)-3,5-dimethylphenol (Intermediate A22 F OH A22 To a solution of Intermediate A21 (2.4 g, 14.3 mmol) in ethanol (30 mL) at 0°C was added NaBH. (540 mg, 14.3 mmol) portionwise. The reaction was warmed to rt with stirring for 1.5 h. The reaction was quenched with water (50 mL), acidified to pH~2 with HCI (1N), and extracted with EtOAc {100 mL*2). The combined organic phase was dried over Na,SO4 and concentrated in vacuo to afford Intermediate A22 (2.4 g, 98.8% yield) as a yellow solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.23 IH NMR: {400 MHz, DMSO-ds) 6 9.45 (d, J = 0.8 Hz, 1H), 6.56 (d, J = 9.2 Hz, 1H), 4.60 (brs, 1H), 4.37 (s, 2H), 2.22 (s, 3H), 2.20 (d, J = 2.4 Hz, 3H). 19F NMR: (376 MHz, DMSO-d) § -143.28. INTERMEDIATE A23 Synthesis of ethyl 2-(2-fluoro-4-(hydroxymethyl)-3,5-dimethylphenoxy)acetate Intermediate A23 “CC on oY fe) the resultant mixture was stirred at rt for 3h. The reaction was diluted with EtOAc (80 mL), and filtered. The filtrate was washed with water (30 mL*2), dried over Na;SO,, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 5) to afford Intermediate A23 {1.6 g, 53% vield) as a white solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.57 1H NMR: (400 MHz, DMSO-d) § 6.72 (d, J = 8.4 Hz, 1H), 4.81 (s, 2H), 4.72 (t, J =5.2 Hz, 1H), 4.40 (dd, J = 5.2, 0.8 Hz, 2H), 4.16 (q, J = 6.8 Hz, 2H), 2.28 (s, 3H), 2.23 (d, J = 2.4 Hz, 3H), 1.21 (t, / = 6.8 Hz, 3H). INTERMEDIATE A24 Synthesis of ethyl 2-(4-(chloromethyl)-2-fluoro-3,5-dimethviphenoxylacetate Intermediate A24 “CC oO a 0 A24 To a solution of Intermediate A23 (1.9 g, 7.4 mmol) in DCM (10 mL) at rt were added SOCI; (0.9 g, 7.4 mmol) and a catalytic amount of DMF (0.05 mL); the resultant solution was stirred at rt for 2h. The reaction was concentrated in vacuo to afford Intermediate A24 {2.0 g, 98.5% yield) as a white solid. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.88 1H NMR: (400 MHz, DMSO-d) 6 6.82 (d, J = 8.2 Hz, 1H), 4.85 (s, 2H), 4.76 (d, J = 0.8 Hz, 2H), 4.17 (q, / = 7.2 Hz, 2H), 2.31 (s, 3H), 2.26 (d, J = 2.4 Hz, 3H), 1.21 (t, J = 7.2 Hz, 3H). 19 NMR: (376 MHz, DMSO-d) § -140.27. INTERMEDIATE A25 Synthesis of 2-(3,5-dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A25 Cl ZC cl > o A25 A mixture of 2,4-dichloro-1-fluorobenzene (30 g, 182 mmol), 4,4'-di-tert-butyl- 2,2"-bipyridine (1.2 g, 4.5 mmol), bis(pinacolato)diboron (46.2 g, 182 mmol) and (1,5- cyclooctadiene)(methoxy)iridium(l) dimer (2.4 g, 3.6 mmol) in THF (300 mL) was stirred at 80°C for 6 h under N, atmosphere. The reaction was concentrated in vacuo; the residue was purified by silica gel column chromatography (pet. ether / EtOAc=20 / 1, v / v) to afford Intermediate A25 (50 g, 94 % yield) as a white solid. TLC: EtOAc / pet. ether =1 / 10{v / v), Rf=0.35 IH NMR: {400 MHz, DMSO) § 7.94 {m, 1H), 7.51 {m, 1H), 1.30 (s, 14H). INTERMEDIATE A26 Synthesis of 3,5-dichloro-2-fluorophenol (Intermediate A26 Cl cr Cl OH A28 To a solution of Intermediate A25 (50.0 g, 172 mmol) in THF (1L) at rt was added H20; (100 mL of 30% in water); the resultant mixture was stirred at rt for 3h. The reaction was extracted with EtOAc (50 mL*3); the combined organic phase was washed with brine (200 mL), dried over Na,SOq, and concentrated in vacuo to afford Intermediate A26 (50 8, 99.7% yield, 62% purity) as a white solid. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.2 1H NMR: (400 MHz, DMSQ) 6 10.93 {s, 1H), 7.12 {m, 1H), 6.96 (m, 1H). INTERMEDIATE A27 Synthesis of 3,5-dichloro-2-fluoro-4-(hydroxymethyl)phenol (Intermediate A27 Cl F “YY cy OH A27 To a solution of Intermediate A26 (45.0 g, 157 mmol) in water (200 mL) at rt were added formaldehyde (4.7 g, 157 mmol) and NaOH (6.2 g, 157 mmol); the resultant mixture was stirred at 50°C for 32 h. The reaction mixture was extracted with EtOAc (100 mL*3); the combined organic phase was washed with brine (200 mL), dried over Na;SOs, concentrated in vacuo and purified by silica gel column chromatography (pet. ether / EtOAc=5:1) to afford Intermediate A27 (22 g, 66% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5{v / v), Rf=0.41 1H NMR: (400 MHz, DMSQ) 6 10.85 (s, 1H), 7.01 (d, J = 7.7 Hz, 1H), 5.12 (s, 1H), 4.58 (d, J=5.0 Hz, 2H). INTERMEDIATE A28 Synthesis of ethyl 2-(3,5-dichloro-2-fluoro-4-(hydroxymethyl)phenoxy)acetate Intermediate A28 Cl ol F XX a oN ON 0 A28 To a solution of Intermediate A27 (10.3 g, 49.1 mmol) in DMF (50 mL) at rt were added K,COs (8.1 g, 58.9 mmol) and ethyl 2-bromoacetate (9.0 g, 54 mmol); the resultant mixture was stirred at rt for 16 h. The reaction was poured into water (50 mL), and extracted with EtOAc (50 mL*3); the combined organic phase was washed with brine {200 mL), dried over Na,S0,, and concentrated in vacuo to afford Intermediate A28 (14.0 g, 49.1 mmol, 96% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5({v / v), Rf=0.44 1H NMR: (400 MHz, DMSQ) 6 7.36 {d, J = 7.6 Hz, 1H), 5.22 {t, J = 5.4 Hz, 1H), 5.00 (s, 2H), 4.62 (d, J =5.3 Hz, 2H), 4.18 (d, J = 7.1 Hz, 2H), 1.21 — 1.14 (m, 3H). INTERMEDIATE A29 Synthesis of ethyl 2-(3,5-dichloro-4-(chloromethyl}-2-fluorophenoxy)acetate Intermediate A29 Cl ol Sed al cl oO 0 To a solution of Intermediate A28 (14.5 g, 48.8 mmol) in DCM (50 mL) was added thionyl chloride (8.71 g, 73.6 mmol). After stirring at rt for 3 h, the reaction mixture was concentrated in vacuo to afford Intermediate A29 (14 g, 90% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5{v / v), Rf=0.6 1H NMR: (400 MHz, DMSQ) 6 7.49 {d, J = 7.6 Hz, 1H), 5.04 (s, 2H), 4.87 (s, 2H), 4.18 (m, 2H), 1.21 (t, J = 7.1 Hz, 3H). INTERMEDIATE A30 Synthesis of 2-(3-bromo-5-chloro-2-fluorophenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A30 Br fou cl 5° o A30 A mixture of 1-fluoro-2-bromo-4-chlorobenzene (10.0 g, 47.8 mmol), bis({pinacolato)diboron {12.1 g, 47.8 mmol), (1, 5-cyclooctadiene)(methoxy)iridium(l) dimer (633 mg, 955 umol) and 4,4'-di-tert-butyl-2,2'"-bipyridine (320 mg, 1.2 mmol) in THF (100 mL) was stirred at 80°C overnight under N; atmosphere. Water (60 mL) was added and the resultant mixture was extracted with EtOAc {30 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100 to 1 / 30) to afford Intermediate A30 (14.0 g, 87.4% vield) as a white solid. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.75 1H NMR: {400 MHz, DMSO-ds) 6 7.99 (dd, J = 6.0, 2.8 Hz, 1H), 7.54 (dd, / = 4.4, 2.8 Hz, 1H), 1.30 (s, 12H). INTERMEDIATE A31 Synthesis of 3-bromo-5-chloro-2-fluorophenol (Intermediate A31 Br oC Cl OH A31 To a solution of Intermediate A30 (14.0 g, 41.7 mmol) in THF (100 mL) at rt was added H20; (23.7 mL of 30% aqueous solution, 209 mmol); the mixture was stirred at rt for 2h. The reaction was quenched with Na;5;03 (8.0 g) and extracted with EtOAc (50 mL*3). The combined organic phase was washed with brine {100 mL), dried over Na,SO4 and concentrated in vacuo to afford Intermediate A31 (9.0 g, 95.6% yield) as a yellow liquid. TLC: EtOAc / pet. ether =1 / 10({v / v), Rf=0.5 1H NMR: {400 MHz, DMSO-d) 6 10.90 {s, 1H), 7.20 (dd, / = 4.8, 2.4 Hz, 1H), 7.00 (dd, J = 7.2, 2.4 Hz, 1H). INTERMEDIATE A32 Synthesis of 3-bromo-5-chloro-2-fluoro-4-(hydroxymethyl)phenol (Intermediate A32 Br F “YY 2] OH A32 To a solution of NaOH (6.2 g, 156.6 mmol) in H20 (100 mL) at rt was added Intermediate A31 (9.1 g, 40.4 mmol). The mixture was heated to 45°C and HCHO (4.7 mL of 37% aqueous, 40.4 mmol) was added dropwise. The mixture was stirred at 45°C overnight. The reaction was cooled to rt and diluted with water (50 mL), then acidified to pH~5-6 with 1N HCI and extracted with EtOAc (30 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na;SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=50 / 1 to 5 / 1) to afford Intermediate A32 (4.1g, 39.7% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5({v / v), Rf=0.20 1H NMR: (400 MHz, DMSO-d) & 10.83 {s, 1H), 7.05 (d, J = 7.8 Hz, 1H), 5.10 (t, J = 5.2 Hz, 1H), 4.62 (d, J = 5.1 Hz, 2H). INTERMEDIATE A33 Synthesis of ethyl 2-{3-bromo-5-chloro-2-fluoro-4-(hydroxymethyl)phenoxy)acetate Intermediate A33 Br or Sod HO cl oN 0 A33 To a solution of Intermediate A32 {4.0 g, 15.7 mmol) in DMF (5 mL) at rt were added K.CO3 (2.6 g, 18.8 mmol) and ethyl 2-bromoacetate (2.6 g, 15.7 mmol); the mixture was stirred at rt for 1h. The reaction was poured into water (50 mL); ther mixture was extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na;SOs, and concentrated in vacuo to afford Intermediate A33 (5.0 g, 93.5% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.25 INTERMEDIATE A34 Synthesis of ethyl 2-(3-bromo-5-chloro-4-(chloromethyl)-2-fluorophenoxy)acetate Intermediate A34 Br or XX al cl oO fo) A34 To a solution of Intermediate A33 (5.0 g, 14.6 mmol) in DCM (50 mL) was added SOCI; (2.6 g, 21.9 mmol). The mixture was stirred at rt for 1h. Water (50 mL) was added and the resultant mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine {50 mL), dried over Na;SO, and concentrated in vacuo to afford Intermediate A34 (5.0 g, 94.9 % yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5{(v / v), Rf=0.5 INTERMEDIATE A35 Synthesis of 2-(5-bromo-3-chloro-2-fluorophenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A35 F Br A >. F o A35 A mixture of 1-fluoro-2-chloro-4-bromobenzene (10.0 g, 47.8 mmol), bis(pinacolato)diboron (12.1 g, 47.8 mmol), (1,5-cyclooctadiene)(methoxy)iridium(l) dimer (633 mg, 955 umol) and 4,4'-di-tert-butyl-2,2"-bipyridine (320 mg, 1.2 mmol) in THF (100 mL) was stirred at 80°C overnight under Nz atmosphere, Water (60 mL) was added and the mixture was extracted with EtOAc (30 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SOs, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100 to 1 / 30) to afford Intermediate A35 (14.5 g, 90.6% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.75 1H NMR: (400 MHz, DMSO-d) & 8.03 (dd, J = 6.4, 2.4 Hz, 1H), 7.64 (dd, J = 4.4, 2.8 Hz, 1H), 1.31 (s, 12H). INTERMEDIATE A36 Synthesis of 5-bromo-3-chloro-2-fluorophenol (Intermediate A36) Br F A368 To a solution of Intermediate A35 (14.5 g, 43.2 mmol) in THF (100 mL) at rt was added aqueous H;0, (24.5 mL of 37% aqueous solution, 216 mmol); the mixture was stirred at rt for 2h. Na,S,0s (8.0 g) was added; the mixture was stirred for 20 min, then extracted with EtOAc (50 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na;SOs and concentrated in vacuo to afford Intermediate A36 (9.7 g, 99.5% yield) as a yellow liquid. TIC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.5 INTERMEDIATE A337 Synthesis of 5-bromo-3-chloro-2-fluoro-4-(hydroxymethyl)phenol (Intermediate A37 Br HO ci OH F A37 To a solution of NaOH (2.0 g, 49.1 mmol) in HO {100 mL) at rt was added Intermediate A36 (10.0 g, 40.6 mmol). The mixture was heated to 45°C and formaldehyde (3.3 mL of 37% aqueous, 40.6 mmol) was added dropwise. The mixture was stirred at 45°C overnight. The reaction was cooled to rt and diluted with water (50 mL), then acidified with 1N HCl to pH~5-6 and extracted with EtOAc (30 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether =1 / 50 to 1 / 5) to afford Intermediate A37 (7.6 g, 73.1% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5({v / v), Rf=0.20 IH NMR: {400 MHz, DMSO-d) 6 10.87 {s, 1H), 7.18 (d, J = 8.0 Hz, 1H), 5.12 (t, / = 5.2 Hz, 1H), 4.62 — 4.58 (m, 2H). INTERMEDIATE A38 Synthesis of ethyl 2-(5-bromo-3-chloro-2-fluoro-4-(hydroxymethyl)phenoxy)acetate Intermediate A38 Br HO cl oO F 0 To a solution of Intermediate A37 (7.6 g, 29.7 mmol) in DMF (70 mL) at rt were added K2CO3 (4.9 g, 29.7 mmol) and ethyl 2-bromoacetate (5.0 g, 29.7 mmol); the mixture was stirred at rt for 1h. The reaction was poured into water (50 mL) and extracted with EtOAc (20 mL*3); the combined organic phase was washed with brine (50 mL), dried over Na;SO4, and concentrated in vacuo to afford Intermediate A38 (10.0 g, 99.0% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.25 INTERMEDIATE A39 Synthesis of ethyl 2-(5-bromo-3-chloro-4-{chloromethyl}-2-fluorophenoxy)acetate Intermediate A39 Br Xo F oO A339 To a solution of Intermediate A38 {10.0 g, 29.3 mmol) in DCM (100 mL) was added SOCI; (5.3 g, 43.9 mmol). The mixture was stirred at rt for 1h. Water (50 mL) was added and the mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO,, and concentrated in vacuo to afford Intermediate A39 {10.0 g, 95.2 % yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.5 INTERMEDIATE A40 Synthesis of 2,3,5-trichloro-4-(hydroxymethyl)phenol {Intermediate A40’ of Cl “XX Cl OH To a solution of NaOH (41 mg, 1.01 mmol) in water (10 mL) at rt was added 2,3,5-trichlorophenol (200 mg, 1.01 mmol). The mixture was heated to 45°C, and formaldehyde (82 mg of 37% aqueous solution, 1.01 mmol) was added dropwise. The mixture was stirred at 45°C overnight; the resultant solution was diluted with water (20 mL), acidified with IN HCI to pH~5-6, and extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na,SO, and concentrated in vacuo. The crude product was purified by Prep-TLC (pet. ether / EtOAc=3 / 1) to afford Intermediate A40 (100 mg, 43.4% yield) as a white solid. TLC: Pet. ether / EtOAc= 3 / 1{v / v), Rf= 0.30. LCMS: RT= 1.467 min, [M-1] = 226.8. 1H NMR: {400 MHz, DMSO-d) 6 11.11 {s, 1H), 7.02 (s, 1H), 5.10 (t, J = 5.2 Hz, 1H), 4.62 (d, J= 4.8 Hz, 2H). INTERMEDIATE A41 Synthesis of ethyl 2-(2.3 5-trichloro-4-(hvdroxymethyliphenoxylacetate {Intermediate A41 Cl Ll cl oN ON oO Ad To a solution of Intermediate A40 (100 mg, 0.44 mmol) in DMF (5 mL) at rt were added K,COsz (91 mg, 0.66 mmol) and ethyl bromoacetate (88 mg, 0.53 mmol); the mixture was stirred at rt for 2h. Water (10 mL) was added and the mixture was extracted with EtOAc (20 mL*2). The combined organic phase was washed with water (20 mL*3) and brine {20 mL*2), dried over Na,SO; and concentrated in vacuo to afford Intermediate A41 (130 mg, 94.3% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1 (v / v), Rf=0.42. 1H NMR: (400 MHz, DMSO-ds) § 7.31 (s, 1H), 5.21 (t, J = 5.4 Hz, 1H), 5.04 (s, 2H), 4.66 (d, J=5.2 Hz, 2H), 4.18 (q, J = 7.2 Hz, 2H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A42 Synthesis of ethyl 2-(2,3,5-trichloro-4-(chloromethyl)phenoxylacetate (Intermediate A42 Cl wl Sed cl cl oY Or 0 Ad2 To a solution of Intermediate A41 (130 mg, 0.41 mmol) in DCM (3 mL) at 0°C was added SOCI; {74 mg, 0.62 mmol); the resultant mixture was stirred at rt for 3h. The mixture was concentrated in vacuo to afford Intermediate A42 (115 mg, 83.5% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1 (v / v), Rf=0.72. IH NMR: {400 MHz, DMSO-ds) 6 7.44 (s, 1H), 5.08 {s, 2H), 4.91 (s, 2H), 4.18 (q, / = 7.2 Hz, 2H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A43 Synthesis of 3,5-dichloro-2-(hydroxymethyl)phenol (Intermediate A43 Cl or Cl OH Ad3 To a solution of 4,6-dichlorosalicylaldehyde (2.5 g, 13.09 mmol) in THF (5 mL) at 0°C was added NaBH; (594.19 mg, 15.71 mmol). The mixture was stirred at rt for 2h, then diluted with water (20 mL). The mixture was acidified to pH~4-5 with 2N HCl and extracted with EtOAc (20 mL*2); the combined organic extracts were washed with brine (30 mL), dried over Na;SO, and concentrated in vacuo to afford Intermediate Ad3 (2.3 g, 93% yield) as white solid. TLC: Pet. ether / EtOAc= 3 / 1 (v / v), Rf= 0.24. LCMS: RT= 1.403 min, [M-1] = 190.9. 1H NMR: (400 MHz, DMSO-d) § 10.44 {s, 1H), 6.98 (d, J = 2.0 Hz, 1H), 6.83 (d, J= 2.0 Hz, 1H), 4.51 (s, 2H). INTERMEDIATE A44 Synthesis of 3,5-dichloro-2-methylphenol (Intermediate A44. ol Cl OH Add A mixture of Intermediate A43 (2.1 g, 10.9 mmol), EtsSiH (5.1 g, 43.5 mmol) and TFA (12.4 g, 109 mmol) in DCM (20 mL) was stirred at rt for 2 days. The reaction mixture was diluted with EtOAc {30 mL), washed with brine (10 mL*2), and dried over Na,;SOu. The crude product was concentrated in vacuo and purified by silica gel column chromatography (pet. ether / EtOAc = 50 / 1 to 20 / 1) to afford Intermediate Ad44 (890 mg, 46.2% yield) as a yellow solid. TIC: Pet. ether / EtOAc=3 / 1 {v / v), Rf=0.65. LCMS: RT= 1.505 min, [M-1] = 175.0. 1H NMR: (400 MHz, DMSO-ds) § 10.36 {d, J = 1.2 Hz, 1H), 6.97 {d, J = 2.0 Hz, 1H), 6.80 (d, J=2.0 Hz, 1H), 2.12 {s, 3H). INTERMEDIATE A45 Synthesis of 3,5-dichloro-4-(hydroxymethyl)-2-methylphenol (Intermediate A45' Cl XC Ol OH AdS5 To a solution of NaOH (201 mg, 5.03 mmol) in water (20 mL) at rt was added Intermediate A44 (890 mg, 5.03 mmol). The mixture was heated to 45°C, and formaldehyde (408 mg of 37% aqueous solution, 5.03 mmol) was added dropwise. The mixture was stirred at 45°C overnight, then diluted with water {20 mL) acidified with 1N HCl to pH~5-6, and extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine (30 mL), dried over NazS0s, and concentrated in vacuo. The crude product was purified by silica gel column chromatography {pet. ether / EtOAc = 20 / 1 to 5 / 1) to afford Intermediate A45 (400 mg, 38.4% yield) as a white solid. TLC: Pet. ether / EtOAc= 3 / 1{v / v), Rf= 0.31. LCMS: RT=0.637 min, [M-1] = 205.0. IH NMR: {400 MHz, DMSO-ds) 6 10.28 {s, 1H), 6.84 (s, 1H), 4.94 (t, J = 5.2 Hz, 1H), 4.59 (d, J = 4.8 Hz, 2H), 2.15 {s, 3H). INTERMEDIATE A46 Synthesis of ethyl 2-(3,5-dichloro-4-(hydroxymethyl)-2-methylphenoxy)acetate Intermediate A46 Cl ol ~ cl oY oO To a solution of Intermediate A45 (400 mg, 1.93 mmol) in DMF (5 mL) at rt were added K,COs (400 mg, 2.90 mmol) and ethyl bromoacetate (387 mg, 2.32 mmol). The mixture was stirred at rt for 2h. The reaction mixture was diluted with EtOAc (30 mL), washed with brine (10 mL*2), dried over Na;SO4 and concentrated in vacuo to afford Intermediate A46 {520 mg, 91.8% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1 (v / v), Rf=0.53. 1H NMR: {400 MHz, DMSO-ds) 8 7.07 (s, 1H), 5.06 (t, J = 5.2 Hz, 1H), 4.92 (s, 2H), 4.64 (d, J=5.2 Hz, 2H), 4.17 {q, J = 7.2 Hz, 2H), 2.24 (s, 3H), 1.21 {t, J = 7.2 Hz, 3H). INTERMEDIATE A47 Synthesis of ethyl 2-(3 5-dichloro-4-(chloromethyl)-2-methylphenoxy)acetate Intermediate A47 Cl wl TL, cl oY Or 0 Ad7T To a solution of Intermediate A46 (520 mg, 1.77 mmol) in DCM (5 mL) at 0°C was added SOCI; {316 mg, 2.66 mmol). The mixture was stirred at rt for 2h. The mixture was concentrated in vacuo to afford Intermediate A47 (530 mg, 95.8% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1 (v / v), Rf=0.67. 1H NMR: {400 MHz, DMSO-d) 6 7.18 (s, 1H), 4.96 (s, 2H), 4.89 (s, 2H), 4.17 (q, J = 7.2 Hz, 2H), 2.26 (s, 3H), 1.21 {t, J = 7.2 Hz, 3H). INTERMEDIATE A48 Synthesis of 2-(3-chloro-2-fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A48 Xe Ads To a mixture of 3-chloro-4-fluorotoluene (10.0 g, 69.2 mmol), 4,4'-di-tert- butyl-2,2'-bipyridine (464 mg, 1.73 mmol) and (1,5-cyclooctadiene)(methoxy)iridium(l) dimer (917 mg, 1.38 mmol) in THF (100 mL) was added bis(pinacolato)diboron (17.6 g, 69.2 mmol). The mixture was heated to 80°C overnight. The mixture was cooled to rt; water (20 mL) was added and the resultant mixture was extracted with EtOAc {20 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc =100 / 1 to 30 / 1) to afford Intermediate A48 (17.5 g, 93.5% yield) as a white solid. TLC: Pet. ether / EtOAc= 3 / 1{v / v), Rf= 0.40. 1H NMR: (400 MHz, DMSO-d) § 7.52 (ddd, J = 7.2, 2.4, 0.8 Hz, 1H), 7.37 (ddd, J = 5.2, 2.4, 0.8 Hz, 1H), 2.28 (s, 3H), 1.29 {s, 12H). INTERMEDIATE A49 Synthesis of 3-chloro-2-fluoro-5-methylphenol (Intermediate A49' Cl rt. ox OH To a mixture of Intermediate A48 (2.8 g, 10.35 mmol) in THF (30 mL) was added aqueous H,0; (1.8 g of 30% w / w, 52 mmol). The mixture stirred at rt for 2h. Na;S,03 (8.0 g) was added; the mixture was stirred for 20 min, then extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine {50 mL), dried over Na;SOs, concentrated in vacuo and purified by silica gel column chromatography (pet. ether / EtOAc=100 / 1 to 10 / 1) to afford Intermediate A49 (1.6 g, 96.2% yield) as a yellow oil. TL.C: Pet. ether / EtOAc=5 / 1 (v / v), Rf=0.41. 1H NMR: {400 MHz, DMSO-ds) 6 10.19 {d, / = 4.8 Hz, 1H), 6.74 (ddd, / = 6.0, 2.0, 0.8 Hz, 1H), 6.71 (ddd, J = 8.0, 2.4, 0.8 Hz, 1H), 2.18 (s, 3H). INTERMEDIATE ASO Synthesis of 3-chloro-2-fluoro-4-(hydroxymethyl}-5-methylphenol (Intermediate A50; Cl ol OH A50 To a solution of NaOH (398 mg, 9.96 mmol) in water (20 mL) at rt was added Intermediate A49 (1.6 g, 10 mmol). The mixture was heated to 45°C and aqueous HCHO (889 mg of 37% w / w, 11 mmol) was added dropwise. The mixture was stirred at 45°C overnight, then diluted with water (20 mL), acidified with 1N HCI to pH~5-6, and extracted with EtOAc (20 mL*2). The combined organic phase was washed with brine {30 mL), dried over Na,SO., and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc = 100 / 1 to 5 / 1) to afford Intermediate A50 (1.0 g, 52.6% yield) as a white solid. TLC: Pet. ether / EtOAc=3 / 1 (v / v), Rf=0.37. 1H NMR: (400 MHz, DMSO-ds) 6 10.15 (s, 1H), 6.82 — 6.63 (m, 1H), 4.87 (t, J =5.2 Hz, 1H), 4.52 — 4.47 {m, 2H), 2.29 (s, 3H). INTERMEDIATE AS51 Synthesis of ethyl 2-(3-chloro-2-fluoro-4-(hydroxymethyl)-5-methylphenoxy)acetate Intermediate A51 Cl F x oN ON fa) 0 AS51 To a solution of Intermediate A50 (900 mg, 4.72 mmol) in DMF (10 mL) at rt were added K,COs (783 mg, 5.67 mmol) and ethyl bromoacetate (788 mg, 4.72 mmol). The mixture was stirred at rt for 1h. Water (30 mL) was added and the resultant mixture was extracted with EtOAc (10 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na,SO, and concentrated in vacuo to afford Intermediate A51 (1.3 g, 99.9 % vield) as a white solid. TLC: pet. ether / EtOAc=3 / 1 {v / v}, Rf=0.45. 1H NMR: (400 MHz, DMSO-d) & 6.98 (d, J = 8.0 Hz, 1H), 4.96 (s, 1H), 4.90 (s, 2H), 4.53 (s, 2H), 4.21 -4.13 {m, 2H), 2.36 — 2.33 (m, 3H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE AS2 Synthesis of ethyl 2-(3-chloro-2-fluoro-4-(hydroxymethyl)-5-methylphenoxy)acetate Intermediate A52 Cl XX Cl 0 NO Fal Oo To a solution of Intermediate A51 (1.3 g, 4.7 mmol) in DCM (20 mL) at rt was added SOCI; (1.1 g, 9.4 mmol). The resultant mixture was stirred at rt for 1h. The mixture was concentrated in vacuo to afford crude Intermediate A52 (1.3 g, 92.8% yield) as a white solid. TLC: pet. ether / EtOAc=3 / 1 {v / v}, Rf=0.57. 1H NMR: (400 MHz, DMSO-ds) § 7.09 (d, J = 8.4 Hz, 1H), 4.94 (s, 2H), 4.83 (d, J = 0.8 Hz, 2H), 4.18 (q, J = 7.2 Hz, 2H), 2.39 — 2.36 (m, 3H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE A53 Synthesis of 2-{5-chloro-2-fluoro-3-methylphenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A53 He AB3 A mixture of 2-fluoro-5-chlorotoluene (6.0 g, 41.5 mmol), bis(pinacolato)diboron (10.5 g, 41.5 mmol), (1, 5-cyclooctadiene) (methoxy)iridium(l) dimer (550 mg, 830 umol) and 4,4'-di-tert-butyl-2,2'-bipyridine (268 mg, 1.0 mmol) in THF (60 mL) was stirred at 80°C overnight under an N; atmosphere. Water (60 mL) was added and the resultant mixture was extracted with EtOAc {30 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100 to 1 / 30) to afford Intermediate A53 (9.4 g, 83.9% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.75 1H NMR: (400 MHz, DMSO-ds) &§ 7.50 (dd, J = 6.0, 2.8 Hz, 1H), 7.37 — 7.34 (m, 1H), 2.20 (d, J=2.4 Hz, 3H), 1.28 {s, 12H). INTERMEDIATE A554 Synthesis of 5-chloro-2-fluoro-3-methylphenol (Intermediate A54. jod Cl OH AS54 To a solution of Intermediate A53 (9.4 g, 34.7 mmol) in THF (100 mL) at rt was added aqueous H;0; {30% w / w) (19.7 g, 174 mmol); the resultant mixture was stirred at rt for 2h. The reaction was cooled to 0°C and Na,S,0; (15.0 g) was added. Water (100 mL) was added; the mixture was stirred for 20 min, then extracted with EtOAc (50 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SOs and concentrated in vacuo to afford Intermediate A54 (5.0 g, 89.3% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.5 LCMS: RT=1.246 min, [M-1] = 159.0 INTERMEDIATE ASRS Synthesis of 5-chloro-2-fluoro-4-(hydroxymethyl}-3-methylphenol (Intermediate A55 F “CX Cl OH AS55 To a solution of NaOH (1.4 g, 34.3 mmol) in HO (50 mL) at rt was added Intermediate A54 (50.0 g, 31.3 mmol). The mixture was heated to 45°C and aqueous HCHO (2.5 g of 37% w / w, 31.3 mmol) was added dropwise. The mixture was stirred at 45°C overnight. The reaction was cooled to rt and diluted with water (60 mL), acidified with 1N HCI to pH~5-6 and extracted with EtOAc (30 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether =1 / 50 to 1 / 5) to afford Intermediate 55 (2.0 g, 33.9% vield) as a white solid. TLC: EtOAc / pet. ether =1 / 5({v / v), Rf=0.20 1H NMR: (400 MHz, DMSO-ds) § 10.20 {s, 1H), 6.82 (d, J = 8.0 Hz, 1H), 4.92 (t, J =5.2 Hz, 1H), 4.51 (d, J = 3.2 Hz, 2H), 2.27 (d, J = 2.8 Hz, 3H). INTERMEDIATE AS6 Synthesis of ethyl 2-(5-chloro-2-fluoro-4-{hydroxymethyl)-3-methylphenoxy)acetate (Intermediate A56) cl oN oO 0 A56 To a solution of Intermediate A55 (2.0 g, 10.5 mmol) in DMF (20 mL) at rt were added K,CO; (1.7 g, 12.6 mmol) and ethyl bromoacetate {1.8 g, 10.5 mmol). The mixture was stirred at rt for 1h. The reaction was poured into water {50 mL) and extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SOs, and concentrated in vacuo to afford Intermediate A56 (2.8 g, 96.6% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5{v / v), Rf=0.25 INTERMEDIATE A57 Synthesis of ethyl 2-(5-chloro-4-{chloromethyl}-2-fluoro-3-methylphenoxy)acetate Intermediate A57 F Cl x oO 0 To a solution of Intermediate A56 (2.8 g, 10.1 mmol) in DCM (100 mL) was added SOCI; (1.8 g, 15.2 mmol). The mixture was stirred at rt for 1h. Water (50 mL) was added and the resultant mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO4 and concentrated in vacuo to afford Intermediate A57 (2.8 g, 93.3% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.5 INTERMEDIATE AS8 Synthesis of 2-(2,3-difluoro-5-methylphenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A58 Lhe AS8 To 1,2-difluoro-4-methylbenzene (8.0 g, 62 mmol), 4,4'-Di-tert-butyl-2,2'- bipyridine (419 mg, 1.56 mmol) and [Ir(OMe)(1,5-cod)]2 (828 mg, 1.25 mmol) in THF (80 mL) was added B2Pin2 (15.9 g, 62.4 mmol). The mixture was heated to 80°C overnight and was cooled down to rt. Water (100 mL) was added, and the mixture was extracted with EtOAc (50 mL*3). The combined organic layer was washed with brine (100 mL), dried over Na;SO. and concentrated in vaccum. The crude product was purified by silica gel column (EtOAc / pet.ether=1 / 100) to afford Intermediate A58 (11.0 g, 69% yield) as a white solid. 1H NMR: {400 MHz, DMSO-ds) § 7.42 — 7.33 {m, 1H), 7.22 (ddt, ] = 4.5, 2.2, 1.1 Hz, 1H), 2.29 (s, 3H), 1.30 {s, 12H). INTERMEDIATE AS9 Synthesis of 2,3-difluoro-5-methylphenol (Intermediate ASS’ F 1X OH AB9 To Intermediate A58 (11 g, 43 mmol) in THF {100 mL) was added hydrogen peroxide (24.5 g, 216 mmol, 22 mL, 30% wt / wt). The mixture was stirred at rt for 2h. Na,S;0; (4.0 g) was added and the mixture was extracted with EtOAc (50 mL*3). The combined organic phase was washed by brine (100 mL), dried over Na,S0s, concentrated in vacuum and purified by silica gel column {pet.ether / EtOAc=100 / 1 to 5 / 1) to afford Intermediate AS9 (6 g, 96% yield) as yellow oil. LCMS: T=0.98 min, [M-1]=143.1 INTERMEDIATE A60 Synthesis of 2,3-difluoro-4-(hydroxymethyl)-5-methylphenol (Intermediate A60 F F CX OH A600 To a solution of NaOH (916 mg, 22.90 mmol) in water (30 mL) at rt was added Intermediate A59 (3 g, 21 mmol). The mixture was heated to 45°C, 37 % formaldehyde (1.7 g, 20.8 mmol, 2 mL, 37% wt / wt) was added dropwise. The mixture was stirred at 45°C overnight and cooled down. The mixture was diluted with water (20 mL), acidified to pH=6-7 with 1M HCI and extracted with EtOAc (50 mL*3). The organic phase was washed by brine (50 mL), dried over Na;SO4 and concentrated in vacuum. The crude product was purified with silica gel column (Pet.ether / EtOAc=20 / 1 to 5 / 1) to afford Intermediate A60 (1.2 g, 33%) as a white solid. HNMR (400 MHz, DMSO-ds) § 10.15 (s, 1H), 6.59 (dd, J = 8.1, 1.9 Hz, 1H), 4.89 (t, J = 5.4 Hz, 1H), 4.42 — 4.38 (m, 2H), 2.25 (s, 3H). INTERMEDIATE A61 Synthesis of ethyl 2-(2,3-difluoro-4-(hydroxymethyl)-5-methylphenoxy)acetate Intermediate A61 F E oY oO 0 0 AB1 To a solution of intermediate A60 (800 mg, 4.6 mmol) in DMF (10 mL) at rt was added K,CO; (762 mg, 5.51 mmol) and ethyl 2-bromoacetate (767 mg, 4.59 mmol). The mixture was stirred at rt overnight, diluted with water (30 mL) and was extracted with EtOAc (20 mL*3). The combined organic phase was washed by brine (10 mL), dried over Na,SOs, concentrated under reduce pressure to afford compound 5 (1.0 g, 83.7% yield) as a white solid. INTERMEDIATE A62 Synthesis of 2-(2,5-difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate A62 Ane AB2 To a solution of 1-bromo-2,5-difluoro-3-methylbenzene (500 mg, 2.42 mmol) and Bis(pinacolato)diboron (920 mg, 3.62 mmol) in 1,4-dioxane (19 mL) was added KOAc (948 mg, 9.66 mmol) and Pd{dppf)Cl2 (197 mg, 0.24 mmol) .The mixture was stirred at 85°C overnight and was cooled down to rt. The mixture was diluted with water (100 mL) and was extracted with EtOAc {100 mL). The organic phase was dried over Na,SOs, concentrated under vacuum and purified by silica gel chromatography (EtOAc / pet.ether=1 / 5) to afford the Intermediate A62 (350 mg, 57% yield) as a white solid. HNMR (400 MHz, DMSO-ds) § 7.34 — 7.26 (m, 1H), 7.10 (dt, J = 7.9, 3.7 Hz, 1H), 2.21 (d, J = 2.3 Hz, 3H), 1.29 (s, 12H). INTERMEDIATE A63 Synthesis of ethyl 2-(2,5-difluoro-4-{hydroxymethyl)-3-methylphenoxy)acetate Intermediate A63 F oY ~ 0 (30 mL) and DCM (30 mL). The organic phase was washed with brine (30 mL), dried over Na,SOq, concentrated under vacuum. The resulting yellow solid (177 mg, 1.23 mmol), along with NaOH (54 mg, 1.35 mmol) was dissolved in water (5 mL) and was heated to 45°C. Formaldehyde (40 mg, 1.35 mmol) was added and the mixture was stirred at 45°C overnight. After cooling to rt, the mixture was acidified with IN HCl to pH~7, diluted with water (30 mL) and was extracted with EtOAc (30 mL). The organic phase was dried over Na,SO,, concentrated under reduce pressure. The resulting solid was dissolved in DMF (3 mL) and ethyl 2-bromoacetate (253 mg, 1.52 mmol) and K,CO3 (261 mg, 1.89 mmol) were added. The mixture was stirred at rt for 2h and was partitioned between water {30 mL) and EtOAc (30 mL). The organic phase was washed with water (30 mL*3) and brine (30 mL), dried over Na,SOs, concentrated under vacuum to afford the product Intermediate A63 (328 mg, 91% vield) as white solid. HNMR (400 MHz, DMSO-d) § 7.95 (s, 4H), 6.89 (dd, J = 11.2, 7.2 Hz, 1H), 4.88 (s, 2H), 4.43 {s, 2H), 4.16 (s, 3H), 4.11 {s, 1H), 2.27 {d, J = 2.6 Hz, 3H), 1.21 (s, SH). INTERMEDIATE A64 Synthesis of ethyl 2-(4-(chloromethyl)-2,5-difluoro-3-methylphenoxylacetate Intermediate A64 F Cl on 0 A64 To a solution of Intermediate A63 {328 mg, 1.26 mmol) in DCM (4 mL) was added thionyl chloride (225 mg, 1.89 mmol).The mixture was stirred at rt 1h.The mixture was concentrated under vacuum to afford the Intermediate A64 (276 mg, 79% yield) as yellow solid. 1H NMR (400 MHz, DMSO-d) 6 7.01 (dd, J = 11.4, 7.2 Hz, 1H), 4.92 (s, 2H), 4.77 (d, J = 1.7 Hz, 2H), 4.17 {q, J = 7.1 Hz, 2H), 2.30 (d, J = 2.6 Hz, 3H), 1.21 (t, J = 7.1 Hz, 3H). INTERMEDIATE A65 Synthesis of (6-chloro-2,3-difluorophenyl)methanol (Intermediate A65. Cl l HO F | F AB5 To a solution of &-chloro-2,3-difluorobenzaldehyde (3.0 g, 16 mmol) in THF (30 mL) at rt was added NaBH4 {707 mg, 18.7 mmol). The mixture was heated to 50°C and stirred overnight and was cooled down to rt. H20 (50 mL) was added. The mixture was extracted with EtOAc (25 mL *2). The combined organic layer was washed with water (25 mL*2), brine (50 mL), dried over Na2504 and was concentrated to dryness to afford Intermediate A65 (2.8 g, 92% yield) as a white solid. 1H NMR: (400 MHz, DMSO-d6) 6 7.45 (dt, J = 10.1, 8.8 Hz, 1H), 7.35 (ddd, ] =9.0, 4.5, 1.9 Hz, 1H), 5.36 {s, 1H), 4.59 {d, J = 2.5 Hz, 2H). INTERMEDIATE A66 Synthesis of tert-butvl{{6-chloro-2,3-difluorobenzyljoxyldimethylsilane (Intermediate A66. Cl Wl TBSO F F To intermediate A65 (2.8 g, 16 mmol), imidazole (2.1 g, 31 mmol) in DCM (30 mL) at rt was added TBSCI (2.6 g, 17 mmol). The mixture was stirred at rt for 1h. The mixture was diluted with H20 (30 mL), extracted with DCM (25 mL *2). The combined organic layer was washed with water (25 mL*2), brine (50 mL), dried over Na,SO¢, concentrated to dryness to afford Intermediate A66 (4.5 g, 98% yield) as a colorless oil. 1H NMR: (400 MHz, DMSO-d) § 7.49 (dt, J = 10.0, 8.8 Hz, 1H), 7.38 (ddd, J = 9.0, 4.2, 1.7 Hz, 1H), 4.81 — 4.76 {m, 2H), 0.85 (s, 9H), 0.08 {s, 6H). INTERMEDIATE A667 Synthesis of ethyl 2-(5-chloro-2,3-difluoro-4-{hydroxymethyl)phenoxy)acetate Intermediate A67 F Cl TBSO E 5° F o AB67 Intermediate A66 (5.8 g, 19.81 mmol), Bis(pinacolato)diboron (5.0 g, 20 mmol), [Ir{OMe)(1,5-cod)]; (263 mg, 0.400 mmol) and 4,4'-Di-tert-butyl-2,2'-bipyridine (133 mg, 0.501 mmol) in THF {40 mL) was stirred at 80°C for 4 h. The mixture was cooled down to rt. The mixture was diluted with H20 (30 mL), extracted with EtOAc (10 mL *2). The combined organic layer was washed with water {20 mL*2), brine (20 mL), dried over Na;SOs, purified with silica gel column (Pet.ether to Pet.ether / EtOAc = 10 / 1) to afford Intermediate A67 (7.0 g, 84% yield) as a colorless oil. IH NMR: (400 MHz, DMSO-ds) & 7.42 (dd, / = 4.4, 2.0 Hz, 1H), 4.79 (d, J = 2.2 Hz, 2H), 1.31 (s, 12H), 0.85 (s, 9H), 0.08 (s, 6H). INTERMEDIATE A68 Synthesis of 4-({{tert-butyldimethylsilyl)oxy)methyl)-5-chloro-2,3-difluorophenol Intermediate A68 Cl et = F OH F ABS To Intermediate A67 (7.8 g, 19 mmol) in THF (80 mL) was added hydrogen peroxide (3.2 g, 93 mmol). The mixture was stirred at rt overnight. The mixture was diluted with H,0 (100 mL) and was extracted with EtOAc (50 mL *2). The combined organic layer was washed with water (50 mL*2), brine {50 mL), dried over Na,SO,, purified by silica column (Pet.ether / EtOAc = 10 / 1) to afford Intermediate A68 (4.7 g, 82% yield) as a white solid. 1H NMR: (400 MHz, DMSO-d) & 10.98 (s, 1H), 6.88 (dd, / = 7.3, 2.1 Hz, 1H), 4.68 (d, J = 2.2 Hz, 2H), 0.85 (d, J=1.3 Hz, 9H), 0.06 (d, J = 1.4 Hz, 6H). INTERMEDIATE A69 Synthesis of ethyl 2-(4-({{tert-butyldimethylsilyl}oxy)methyl)-5-chloro-2,3- difluorophenoxy)acetate {Intermediate A69’ Cl Gl = F oN Or F 0 AB9 Intermediate A68 (3.0 g, 9.7 mmol), K;CO3 (2.0 g, 15 mmol) and ethyl 2- bromoacetate (2.0 g, 11.66 mmol) in DMF (30 mL) was stirred at rt for 3 h. The mixture was diluted with H,0 (100 mL), extracted with EtOAc (25 mL). The combined organic layer was washed with water (25 mL*5), brine (50 mL), dried over Na;SO4, concentrated to dryness to afford product Intermediate A69 (3.5 g, 91% yield) as a yellow solid. 1H NMR: (400 MHz, DMSO-d) § 7.24 (dd, J = 7.1, 2.1 Hz, 1H), 5.00 (s, 2H), 4.72 (d, J = 2.2 Hz, 2H), 4.21 — 4.15 (m, 2H), 1.21 (dd, J = 7.4, 6.8 Hz, 3H), 0.85 (s, 9H), 0.08 (s, 6H). INTERMEDIATE A70 Synthesis of ethyl 2-(5-chloro-4-{chloromethyl)-2,3-difluorophenoxy)acetate Intermediate A70 Cl Ol, Or F oO A70 To a solution of Intermediate A69 (3.5 g, 8.9 mmol) in DCM (20 mL) was added TBAF {1 M in THF, 9.8 mL). The mixture was stirred at rt for 1 h. The mixture was diluted with H,0 (50 mL) and was extracted with DCM {25 mL). The combined organic layer was washed with water (25 mL*2), brine (50 mL), dried over Na,SQO4 and was concentrated to dryness to afford compound 7 (2.4 g, 97% yield) as a colorless oil. To a solution of compound 7 {2.4 g, 8.6 mmol) in DCM (20 mL) was added SOCl; (1.5 g, 12.8 mmol). The mixture was stirred at rt for 2 h. The mixture was concentrated to dryness to afford Intermediate A70 (2.5 g, 94% vield) as a white solid. 1H NMR: (400 MHz, DMSO-de) 6 7.35 (dd, J = 7.2, 2.2 Hz, 1H), 5.04 (s, 2H), 4.80 (d, J = 1.9 Hz, 2H), 4.18 (q, J=7.1Hz, 2H), 1.21 (t, J = 7.1 Hz, 3H). INTERMEDIATE A71 Synthesis of 3-chloro-2,5-difluoro-4-(hydroxymethyl)phenol (Intermediate A71 Cl r ~~ F OH AT To 2-chloro-1,4-difluorobenzene (19.8 g, 133 mmol), 4,4'-Di-tert-butyl-2,2'- bipyridine (894 mg, 3.33 mmol) and [Ir{OMe)(1,5-cod)]; (1.7 g, 2.67 mmol) in THF (100 mL) was added 4,4'-Di-tert-butyl-2,2'-bipyridine (33.8 g, 133.30 mmol). The mixture was heated to 80°C overnight and was cooled down to rt. Water (80 mL) was added and the mixture was extracted with EtOAc (50 mL*3). The combined organic phase was washed with brine (80 mL), dried over Na;SO4 and concentrated in vacuum. The resulting solid was dissolved in THF (100 mL) and hydrogen peroxide (22.6 g, 664.85 mmol, 68.5 mL) was added at 0°C. The mixture was stirred at rt 4h. The reaction was quenched with Na,S,0s aqueous saturated (10 mL) and was extracted with EtOAc (100 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na;SO; and concentrated in vacuum. The resulting solid was dissolved in water (30 mL) at rt and NaOH (1.8 g, 45.58 mmol) was added. The mixture was heated to 45 °C, CH.0 (3.7 g, 45.58 mmol) was added dropwise. The mixture was stirred at 45 °C overnight and cooled down to rt. The mixture was diluted with water {20 mL), acidified to pH=5-6 with 1 N HCl and was extracted with EtOAc (50 mL*2). The combined organic phase was washed by brine (60 mL), dried over Na;SO., concentrated under reduce pressure. The crude product was purified with silica gel column (Pet.ether / EtOAc = 20 / 1 to 5 / 1) to afford Intermediate A71 {1.5 g, 6% yield) as a white solid. LCMS: T=0.36 min, [M-1] =193.0 INTERMEDIATE A72 Synthesis of ethyl 2-(3-chloro-2,5-difluoro-4-(hydroxymethyl)phenoxy)acetate Intermediate A72 Cl wl E HO’ o ~ F oY oO AT72 To a solution of Intermediate A71 {500 mg, 2.57 mmol} in DMF (6 mL) at rt was added K2CO3 (533 mg, 3.85 mmol) and ethyl 2-bromoacetate (515 mg, 3.08 mmol). The mixture was stirred at rt 2h. The reaction mixture was diluted with EtOAc (30 mL), washed with brine (10 mL*2), dried over Na,SO, and was concentrated in vacuum to afford Intermediate A72 (710 mg, 98% yield) as a white solid. H NMR: (400 MHz, DMSO-ds) § 7.20 (dd, J = 11.2, 7.0 Hz, 1H), 5.21 (s, 1H), 4.97 (s, 2H), 4.51 (s, 2H), 4.18 {t, J = 7.2 Hz, 2H), 1.21 {t, J = 7.2 Hz, 3H). INTERMEDIATE A73 Synthesis of ethyl 2-(3-chloro-4-{chloromethyl)-2,5-difluorophenoxy)acetate Intermediate A73 Cl wl F 0 NO oO A73 To a solution of Intermediate A72 (710 mg, 2.53 mmol) in DCM (5 mL) at 0°C was added thionyl chloride {451 mg, 3.79 mmol). The mixture was stirred at rt 2 h. The mixture was concentrated in vacuum to afford crude Intermediate A73 (688 mg, 91% yield) as yellow solid. HNMR: H NMR (400 MHz, DMSO-ds) § 7.34 (dd, J = 11.5, 7.0 Hz, 1H), 5.00 (s, 2H), 4.79 (d, J=1.6 Hz, 2H), 4.18 (q, J = 7.1 Hz, 2H), 1.21 (t, J = 7.1 Hz, 3H). INTERMEDIATE A74 Synthesis of 4-(benzyloxy}-2,6-dichlorobenzaldehyde {Intermediate A74! Cl Ci OBn A74 To a solution of 2,6-dichloro-4-hydroxybenzaldehyde (6.5 g, 34 mmol) in DMF (50 mL) was added K,CO; (5.6 g, 41 mmol) and BnBr (5.8 g, 34 mmol). The mixture was stirred at rt for 2 h, diluted with water (50 mL), was extracted with EtOAc (30 mL*3). The combined organic phase was washed by brine (50 mL), dried over Na;50s, concentrated in vacuum and washed by n-hexane to afford intermediate A74 (8.6 g, 90% yield) as a white solid. 1H NMR: (400 MHz, DMSO-d) 6 10.28 (s, 1H), 7.49 — 7.35 (m, 5H), 7.30 (s, 2H), 5.27 (s, 2H). INTERMEDIATE A75 Synthesis of 2,4-dichloro-6-iodophenol (Intermediate A75' Cl or Cl 1 A75 To a solution of 2,4-dichlorophenol {5.0 g, 30.67 mmol) in DCM (30 mL) was added NIS (8.3 g, 36.81 mmol) and TsOH (1.2 g, 6.13 mmol). The mixture was stirred at rt overnight. The mixture was diluted with H;0 (50 mL) and was extracted DCM (50 mL). The organic phase was washed by brine (20 mL), dried over Na,SO, and was concentrated in vacuum to afford Intermediate A75 (2.0 g, 23% yield) as a white solid. LCMS: T= 2.376 min, [M-1] = 286.7 INTERMEDIATE A76 Synthesis of 1,5-dichloro-3-iodo-2-methoxybenzene (Intermediate A76 Cl oe Cl | AT8 To a solution of Intermediate A75 (1.5 g, 5.33 mmol) in DMF (10 mL) was added K2CO3 (1.1 g, 8.00 mmol) and Mel (1.1 g, 8.00 mmol). The reaction was stirred at rt 3h. The mixture was diluted with HO (50 mL) and was extracted EtOAc (20 mL*2). The combined organic phase was washed by brine (50 mL*2), dried over Na;SO. and was concentrated in vacuum to afford Intermediate A76 (1.5 g, 97% yield) as a brown solid. 1H NMR: (400 MHz, DMSO-d) 6 7.89 (d, J = 2.5 Hz, 1H), 7.71 (d, J = 2.5 Hz, 1H), 3.77 (s, 3H). INTERMEDIATE A77 Synthesis of 3,5-dichloro-2-methoxyphenol (Intermediate A77 Cl oe Cl OH AT? To a solution of Intermediate A76 (1.7 g, 5.8 mmol) in water (1 mL) at rt was added KOH (1.3 g, 23 mmol), Pd.(dba)s {532 mg, 0.58 mmol) and tBuXPhos (247 mg, 0.58 mmol). The reaction was heated to 100°C overnight and was cooled down to rt. The reaction mixture was diluted with H20 (50 mL), extracted EtOAc (20 mL*2). The combined organic phase was washed with brine (20 mL*2), dried over Na,SO,, concentrated under reduce pressure. The crude product was purified with silica gel column (Pet.ether / EtOAc = 50 / 1) to afford Intermediate A77 (560 mg, 50% yield) as a brown solid. LCMS: T= 1.256 min, [M -1] = 190.9 INTERMEDIATE A78 Synthesis of 3,5-dichloro-4-(hydroxymethyl)-2-methoxyphenol {Intermediate A78 Ci o “0 Cl OH A78 To a solution of NaOH (113 mg, 2.83 mmol) in water (20 mL) at rt was added Intermediate A77 {546 mg, 2.83 mmol). The mixture was heated to 45 °C, CH,0 (230 mg, 2.83 mmol) was added dropwise. The mixture was stirred at 45 °C overnight and cooled down to rt. The mixture was diluted with water (20 mL), acidified to pH=5-6 by 1 N HCl and was extracted with EtOAc (20 mL*2). The combined organic phase was washed by brine (30 mL), dried over Na;SO,, and was concentrated under reduce pressure. The crude product was purified with silica gel column (Pet.ether / EtOAc = 20 / 1 to 5 / 1) to afford Intermediate A78 (280 mg, 44% yield) as a white solid. LCMS: T= 1.052 min, [M -1] = 220.9 INTERMEDIATE A79 Synthesis of ethyl 2-(3,5-dichloro-4-(hydroxymethyl)-2-methoxyphenoxy)acetate Intermediate A79 Cl wl “CC cl oN ON oO ATO To a solution of Intermediate A78 (280 mg, 1.26 mmol) in DMF (5 mL) at rt was added K.COs (260 mg, 1.88 mmol) and ethyl 2-bromoacetate (251 mg, 1.51 mmol). The mixture was stirred at rt 2h. The reaction mixture was diluted with EtOAc (30 mL), washed with brine (20 mL*2), dried over Na,SO, and concentrated in vacuum to afford Intermediate A79 (380 mg, 98% yield) as a white solid. 1H NMR; (400 MHz, DMSO-de) 6 7.17 (5, 1H), 5.12 {t, J = 5.2 Hz, 1H), 4.96 (s, 2H), 4.60 (d, J = 5.2 Hz, 2H), 4.18 (t, J = 7.2 Hz, 2H), 3.79 (s, 3H), 1.21 {t, J = 7.2 Hz, 3H). INTERMEDIATE A80 Synthesis of ethyl 2-(3,5-dichloro-4-{chloromethyl})-2-methoxyphenoxy)acetate Intermediate A80 Cl Wl Co cl oO oO ABO To a solution of Intermediate A79 (380 mg, 1.23 mmol) in DCM (5 mL) at 0°C was added SOCI; (219 mg, 1.84 mmol). The mixture was stirred at rt 2 h. The mixture was concentrated in vacuum to afford Intermediate A80 (378 mg, 94% yield) as a white solid. 1H NMR; (400 MHz, DMSO-d) § 7.29 (s, 1H), 5.00 {s, 2H), 4.86 {s, 2H), 4.18 (q, J = 7.2 Hz, 2H), 3.82 (s, 3H), 1.21 (t, J = 7.2 Hz, 3H). INTERMEDIATE B1 Synthesis of 3-fluoro-2-{prop-1-en-2-yl}phenol (Intermediate B1 F v HO B1 To a mixture of 2-bromo-3-fluorophenol (38.0 g, 200 mmol), isopropenyl-2- boron{pinacolate) (50.4 g, 300 mmol) and Pd(dppf)Cl,:CH,Cl; {16.3 g, 20 mmol) in 1,4-dioxane (300 mL) and water (30 mL) at rt was added K,COs (55.3 g, 400 mmol). The mixture was heated to 70°C and stirred overnight. The reaction mixture was cooled to rt, quenched with water (100 mL) and extracted with EtOAc (100 mL*3). The combined organic phase was washed with brine (200 mL), dried over Na,SO4, concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether =1 / 100 to 1 / 20) to afford Intermediate B1 (23.0 g, 76% yield) as white solid. TLC: EtOAc / pet.ether =1 / 10(v / v), Rf=0.55 1H NMR: {400 MHz, DMSO-ds) 6 9.72 (s, 1H), 7.06 (td, J = 8.4, 6.8 Hz, 1H), 6.66 (td, J = 8.4, 1.2 Hz, 1H), 6.59 {m, 1.0 Hz, 1H), 5.28 (m, 1H), 4.89 (m, 1H), 1.98 (s, 3H). INTERMEDIATE B2 Synthesis of 3-fluoro-2-isopropylphenol (Intermediate B2 F O To a solution of Intermediate B1 (23.0 g, 151 mmol) in MeOH (300 mL) was added Pd / C (10%) (6.0 g). The reaction mixture was stirred at 60°C overnight. The mixture was cooled to 0°C, filtered, and concentrated in vacuo to afford Intermediate B2 (21.0 g, 90% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 50({v / v), R=0.25 1H NMR: (400 MHz, DMSO-ds) § 9.69 (s, 1H), 7.00 — 6.93 (m, 1H), 6.65 — 6.60 (m, 1H), 6.52 (ddd, J = 10.8, 8.0, 1.2 Hz, 1H), 3.40 {m, 1H), 1.25 (dd, / = 7.2, 1.2 Hz, 6H). INTERMEDIATE B3 Synthesis of 2-(3-(difluoromethoxy)phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate B3 F Fo 8° SC B3 A mixture of 3-bromophenyl difluoromethyl ether (250 mg, 1.12 mmol), bis(pinacolato)diboron (311 mg, 1.23 mmol), Pd(dppf)Cl; (73 mg, 0.10 mmol) and KOAc (323 mg, 3.36 mmol) in 1,4-dioxane {5 mL) was stirred at 80°C overnight. The mixture was filtered and concentrated in vacuo to afford Intermediate B3 (270 mg, 89.4% yield) as a black oil which was used without further purification. TLC: Pet. ether / EtOAc=10 / 1{v / v), Rf=0.8 B4 To a solution of 4-fluoroacetophenone (10.0 g, 72.4 mmol), P(OPh); (35.4 g, 109 mmol) and triethylamine (11.7 g, 116 mmol) in DCM (100 mL) at -15°C was added Br; (17.4 8, 109 mmol) dropwise. The mixture was stirred at rt for 1h. The mixture was concentrated to dryness and purified by silica gel column chromatography (pet. ether eluant) to afford Intermediate B4 (8.0 g, 54.9% yield) as a colorless oil that is best stored at 0°C. TLC: Pet. ether, R=0.91 1H NMR: (400 MHz, Chloroform-d) & 7.63 — 7.50 (m, 2H), 7.03 {t, J = 8.7 Hz, 2H), 6.05 (d, J=2.1Hz, 1H), 5.76 {d, J = 2.0 Hz, 1H). INTERMEDIATE BS Synthesis of 2-(1-(4-fluorophenylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Intermediate B5 F Ago L mmol) in toluene (50 mL) was stirred at 100°C overnight. The mixture was concentrated in vacuo. Water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na SOs, concentrated in vacuo, and purified by silica gel column chromatography (pet. ether / EtOAc = 20 / 1) to afford Intermediate BS (1.5 g, 40.5% yield) as a yellow oil. TLC: Pet. ether, R=0.69 1H NMR: {400 MHz, Chloroform-d) § 7.45 (dd, J = 8.7, 5.6 Hz, 2H), 7.00 (t, J = 8.8 Hz, 2H), 6.04 (s, 2H), 1.32 {s, 12H). INTERMEDIATE B6 Synthesis of 3-fluoro-2-(4-fluorobenzyliphenol (Intermediate B6 F F 0 To a solution of 4-fluorobenzyl bromide (1.0 g, 5.29 mmol) and 6-fluoro-2- hydroxyphenylboronic acid {1.2 g, 7.94 mmol) in toluene (10 mL) at rt were added Pd(dppf)Cl. (387 mg, 0.53 mmol) and KsPO, (3.4 g, 15.87 mmol). The reaction was heated to 100°C overnight under N(g). Water (20 mL) was added, and the resultant mixture was extracted with EtOAc (10 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na;SOs, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc =100 / 1-20 / 1) followed by reversed-phase column chromatography to afford Intermediate B6 (180 mg, 15.4% yield) as a light yellow oil. TLC: Pet. ether / EtOAc= 5 / 1{v / v), Rf= 0.29. INTERMEDIATE B7 Synthesis of 3-fluoro-2-(1-(4-fluorophenyl)-1-hydroxypropyl)phenol (Intermediate B7' F HO 4 B7 To a solution of 2-bromo-3-fluorophenol (1.00 g, 5.24 mmol) in THF (10 mL) at -30 °C was added dropwise n-BuLi (2.5 M, 4.00 mL, 10.0 mmol). The reaction mixture was stirred at -30 °C for 30 min and then cooled to -50 °C; (4-fluorophenyl) ethyl ketone (0.73 g, 4.36 mmol) in THF (3 mL) was added dropwise. The mixture was stirred at -50°C for 2h, quenched with aqueous NH4Cl solution (30 mL) and acidified with HCI (1N) to pH~6, then extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine (30 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by reversed- phase column chromatography to afford Intermediate B7 (230 mg, 20% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.36 1H NMR: {400 MHz, DMSO-d) 6 11.07 {s, 1H), 7.47 — 7.40 {m, 2H), 7.36 (s, 1H), 7.18 — 7.04 {m, 3H), 6.58 (dt, = 8.3, 1.1 Hz, 1H), 6.49 (ddd, / = 12.0, 8.2, 1.3 Hz, 1H), 2.49 -2.42 (m, 2H), 2.22 — 2.15 (m, 1H), 0.89 {t, J = 7.2 Hz, 3H). INTERMEDIATE B8 Synthesis of 3-fluoro-2-{1-(4-fluorophenyl)propyl)phenol (Intermediate BS. F F : HO To a solution of Intermediate B7 (230 mg, 1.14 mmol) in DCM (5 mL) at rt was added EtsSiH (528 mg, 4.54 mmol); the mixture was cooled to 0°C, and TFA (3.88 g, 34.1 mmol) was added dropwise. The mixture was stirred at rt for 3h, then concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=50 / 1 to 10 / 1) to afford Intermediate B8 (80 mg, 37% vield) as a yellow ail. TLC: EtOAc / pet. ether =1 / 5{v / v), R=0.60 INTERMEDIATE BS Synthesis of 3-fluoro-2-{1-(4-fluorophenyl}-1-hydroxybutyl)phenol (Intermediate BS F F bo, 4 F | HO | To a solution of 2-bromo-3-fluorophenol (1.00 g, 5.24 mmol) in THF (10 mL) at -30 °C was added dropwise n-Buli (2.5 M, 4.0 mL, 10.0 mmol). The reaction mixture was stirred at -30°C for 30 min, then cooled to -50°C; (4-fluorophenyl) propyl ketone (0.73 g, 4.36 mmol) in THF (3 mL) was added dropwise. The mixture was stirred at -50°C for 2h, quenched with aqueous NH4Cl solution (30 mL) and acidified with HCI (IN) to pH~6, then extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by reversed-phase column chromatography to afford Intermediate B9 (250 mg, 20% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.36 1H NMR: {400 MHz, DMSO-d) 6 11.06 {s, 1H), 7.46 — 7.40 {m, 2H), 7.40 (s, 1H), 7.17 — 7.06 {m, 3H), 6.57 (dt, = 8.2, 1.1 Hz, 1H), 6.49 (ddd, J = 12.0, 8.2, 1.3 Hz, 1H), 2.47 — 2.37 {m, 1H), 2.19 — 2.07 (m, 1H), 2.03 — 1.96 (m, 1H), 1.62 — 1.44 (m, 1H), 0.90 (t, J = 7.4 Hz, 3H). INTERMEDIATE B10 Synthesis of 3-fluoro-2-(1-(4-fluorophenyl)butyl)phenol (Intermediate B10! F B10 To a solution of Intermediate B9 (230 mg, 826 umol) in DCM (5 mL) at rt was added Et;SiH (384 mg, 3.31 mmol). The mixture was cooled to 0°C, and TFA (2.83 g, 24.8 mmol) was added dropwise. The mixture was stirred at rt for 3h, then concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=50 / 1 to 10 / 1) to afford Intermediate B10 (130 mg, 60% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.60 IH NMR: {400 MHz, DMSO-ds) 6 9.88 (d, J = 1.6 Hz, 1H), 7.33 = 7.27 {m, 2H), 7.10 — 7.04 {m, 2H), 7.03 = 6.97 {m, 1H), 6.66 — 6.61 (m, 1H), 6.54 (ddd, / = 10.9, 8.3, 1.1 Hz, 1H), 4.48 — 4.39 (m, 1H), 2.23 — 2.08 (m, 1H), 2.06 — 1.96 (m, 1H), 1.18 (d, J =7.4 Hz, 1H), 0.88 (t, = 7.3 Hz, 3H). INTERMEDIATE B11 Synthesis of 3-chloro-2-(prop-1-en-2-yl)phenol {Intermediate B11, Cl Gl HO B11 To a mixture of 2-bromo-3-chlorophenol (1.0 g, 4.8 mmol), isopropenyl-2- boron(pinacolate) (1.2 g, 7.2 mmol) and Pd{dppf)Cl,:CH,Cl; (170 mg, 0.24 mmol) in 1,4-dioxane (10 mL) and H,0 (2 mL) at rt was added K;CO3 (1.3 g, 9.6 mmol). The mixture was heated to 75°C overnight. The reaction mixture was cooled to rt, quenched with water (30 mL) and extracted with EtOAc (30 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na;SOs, concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether =1 / 20) to afford Intermediate B11 (800 mg, 98% vield) as a white solid. TLC: EtOAc / pet. ether =1 / 10({v / v), Rf=0.55 1H NMR: (400 MHz, DMSQ) 6 9.65 {s, 1H), 7.06 (t, J = 8.1 Hz, 1H), 6.86 (d, J = 8.0 Hz, 1H), 6.79 (d, J = 8.2 Hz, 1H), 5.27 (s, 1H), 4.78 (s, 1H), 1.93 (s, 3H). INTERMEDIATE B12 Synthesis of 3-chloro-2-isopropylphenol {Intermediate B12 Cl wi HO : B12 To a solution of Intermediate B11 (800 mg, 4.7 mmol) in THF (20 mL) was added Raney-Ni (40 mg). The reaction mixture was stirred at 60°C overnight under H, gas (1 atm). The mixture was cooled to 0°C and filtered, then concentrated in vacuo to afford Intermediate B12 (800 mg, 98% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 50({v / v), R=0.25 1H NMR: {400 MHz, DMSO) 8 9.69 {s, 1H), 6.96 (m, 1H), 6.82 — 6.71 (m, 2H), 3.61 — 3.48 {m, 1H), 1.29 (d, J = 7.1 Hz, 6H). INTERMEDIATE B13 Synthesis of 3-methoxy-2-(prop-1-en-2-yl)phenol (Intermediate B13 OMe OMe HO B13 To a solution of 2-bromo-3-methoxyphenol (500 mg, 2.46 mmol) and propenyl-2-boron(pinacolate) (621 mg, 3.69 mmol) in 1.4-dioxane {10 mL) at rt under N; (g) were added Pd(dppf)Cl {360 mg, 0.49 mmol) and K,CO; (681 mg, 4.93 mmol). The mixture was heated to 80°C overnight. The mixture was diluted with EtOAc (20 mL), washed with brine (10 mL*2), dried over Na;SOs, filtered and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether =1 / 100-1 / 10) to afford Intermediate B13 (200 mg, 49.4% yield) as a light yellow liquid. TLC: Pet. ether / EtOAc= 10 / 1({v / v), Rf= 0.75. 1H NMR: (400 MHz, DMSO-ds) § 9.02 (s, 1H), 6.98 (t, J = 8.0 Hz, 1H), 6.43 (ddd, J =9.2, 8.4, 0.8 Hz, 2H), 5.15 (dt, / = 3.2, 1.6 Hz, 1H), 4.71 (dd, / = 2.4, 1.2 Hz, 1H), 3.67 (s, 3H), 1.89 {t, J = 1.2 Hz, 3H). INTERMEDIATE B14 Synthesis of 2-isopropyl-3-methoxyphenol {Intermediate B14 OMe “0 B14 To a solution of Intermediate B13 (400 mg, 2.44 mmol) in THF (10 mL) at rt was added Pd / C (100 mg, 2.44 mmol). The mixture was degassed several times in vacuo, then placed under a H; atmosphere. The mixture was stirred at 60°C overnight. The reaction was filtered and concentrated to afford Intermediate B14 (400 mg, 98.7% vield) as a white solid. TLC: Pet. ether / EtOAc= 10 / 1(v / v), Rf= 0.76. 1H NMR: (400 MHz, DMSO-ds) § 9.11 (s, 1H), 6.89 (t, J = 8.0 Hz, 1H), 6.42 — 6.35 (m, 2H), 3.70 (s, 3H), 3.50 — 3.46 (m, 1H), 1.21 {(d, / = 7.2 Hz, 6H). INTERMEDIATE B15 Synthesis of 3-hydroxy-2-{prop-1-en-2-yl)benzonitrile (Intermediate B15! CN CN HO B15 To a mixture of 2-bromo-3-hydroxybenzonitrile (800 mg, 4.04 mmol), isopropenyl-2-boron(pinacolate) {1.36 g, 8.08 mmol) and Pd(dppf)Cl,:CH,Cl; (260 mg, 0.40 mmol) in 1,4-dioxane (10 mL) and H,0 (2 mL) at rt was added K,CO3 (1.68 g, 12.12 mmol). The mixture was heated to 75°C overnight. The reaction mixture was cooled to rt, quenched with water (30 mL) and extracted with EtOAc {30 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na;SOs, concentrated in vacuo and purified by silica gel column chromatography {EtOAc / pet. ether =1 / 20) to afford Intermediate B15 (400 mg, 62.2% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.55 1H NMR: {400 MHz, DMSO-d) 6 10.13 {s, 1H), 7.30 — 7.20 {m, 2H), 7.12 (dd, / = 7.9, 1.5 Hz, 1H), 5.34 (q, / = 1.6 Hz, 1H), 4.98 — 4.95 (m, 1H), 2.03 (s, 3H). INTERMEDIATE B16 Synthesis of 3-hydroxy-2-isopropylbenzonitrile {Intermediate B16. CN Srl ¥ HO : B16 To a solution of Intermediate B15 (400 mg, 4.7 mmol) in THF (20 mL) was added Pd / C (5%) (40 mg). The reaction mixture was stirred at rt overnight under H, atmosphere. The mixture was filtered, concentrated to dryness, and purified by Prep-TLC (pet. ether / EtOAc = 5 / 1) to afford Intermediate B16 (150 mg, 37.1% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5 (v / v), R=0.61 IH NMR: {400 MHz, DMSO-ds) 6 10.06 {s, 1H), 7.22 — 7.14 (m, 2H), 7.08 (dd, J = 7.0, 2.4 Hz, 1H), 3.41 (p, / = 7.1 Hz, 1H), 1.34 (d, / = 7.1 Hz, 6H). INTERMEDIATE B17 Synthesis of 2-{1-(4-fluorophenyl}-1-hydroxybutyl}phenol (Intermediate B17 F B17 To a solution of 2-bromophenol (1.25 g, 7.22 mmol) in dry THF (15 mL) at - 50°C was added dropwise n-BuLi (15.0 mmol, 6.02 mL of 2.5M). The mixture was warmed to room temperature and stirred for 1h. The resultant solution was cooled to 0°C; 4- fluorophenyl-n-propyl ketone (1.00 g, 6.02 mmol) in THF (5 mL) was added dropwise. The mixture was stirred at room temperature for 2h. NH4Cl (aq) (15 mL) was added. The mixture was acidified to pH~4-5 with 1N HCl, then extracted with DCM (15 mL* 2). The combined organic phase was dried with Na;SOs, concentrated in vacuo, and purified by reversed-phase column chromatography to afford Intermediate B17 (1.0 g, 63.9 % yield) as a colorless oil. TLC: EtOAc / pet. ether =1 / 5{v / v), Rf=0.48 1H NMR: (400 MHz, DMSO-ds) § 9.57 (s, 1H), 7.40 — 7.32 (m, 3H), 7.10 — 7.02 (m, 3H), 6.79 (td, J = 7.6, 1.3 Hz, 1H), 6.66 (dd, J = 8.0, 1.3 Hz, 1H), 6.21 (s, 1H), 2.42 — 2.31 (m, 1H), 2.14 — 2.02 {m, 1H), 1.27 — 1.20 {m, 2H), 0.85 (t, J = 7.4 Hz, 3H). INTERMEDIATE B18 Synthesis of 2-(1-(4-fluorophenyl}butyl)phenol (Intermediate B18 F ~0 B18 A mixture of Intermediate B17 (1.0 g, 3.84 mmol), EtsSiH (1.79 g, 15.4 mmol) and TFA (4.38 g, 38.4 mmol) in DCM (10 mL} was stirred at rt for 3h. The mixture was concentrated in vacuo and purified by silica gel column chromatography to afford product Intermediate B18 (800 mg, 85.2% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.66 1H NMR: (400 MHz, DMSO-ds) § 9.30 (s, 1H), 7.31 — 7.24 (m, 2H), 7.17 (dd, = 8.1, 1.6 Hz, 1H), 7.04 (t, J = 8.9 Hz, 2H), 7.00 — 6.94 (m, 1H), 6.75 (d, J = 7.7 Hz, 2H), 4.29 (t, J = 7.9 Hz, 1H), 1.96 — 1.86 {m, 2H), 1.17 (t, J = 7.1 Hz, 2H), 0.86 (d, J = 7.4 Hz, 3H). INTERMEDIATE B19 Synthesis of 3'-(difluoromethoxy)-[1,1'-biphenyl]-2-ol (Intermediate B19’ OINCEINOXy / -[1,L "DIPNCTyI-2-¢ Ne Fg 0 HO B19 A mixture of Intermediate B3 (3.5 g, 13 mmol), 2-bromophenol (1.5 g, 8.67 mmol), Pd(dppf)Cl; (634 mg, 0.87 mmol) and K,CO; {3.6 g, 26 mmol) in 1,4-dioxane (30 mL) and water (3 mL) was stirred at 90°C overnight. Water {50 mL) was added, and the mixture was extracted with EtOAc (30 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na;SO., and concentrated in vacuo. The residue was purified by silica gel column chromatography (pet. ether / EtOAc = 20 / 1 to 5 / 1, v / v) to afford Intermediate B19 {700 mg, 34% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5 (v / v), Rf=0.54 LCMS: RT=2.551 min; [M-1]= 235.0 INTERMEDIATE B19 Synthesis of 4-iodo-2-isopropyl-1-{methoxymethoxylbenzene {Intermediate B20 - ° Al MOMO B20 To a solution of 4-iodo-2-isopropylphenol (20.0 g, 76.3 mmol) in DCM (200 mL) was added DIEA (29.6 g, 229 mmol) and MOMCI (9.2 g, 114 mmol). The mixture was stirred at rt for 3h. Water (500 mL) was added, and the mixture was extracted with EtOAc (200 mL *3). The combined organic layer was washed by brine (500 mL), dried over Na,SO, and concentrated in vacuum to dryness. The residue was purified by silica gel column (Petroleum ether) to afford Intermediate B20 (14 g, 60% yield) as a yellow oil. 'H NMR: (400 MHz, DMSO-ds) 6 7.45 (d, J = 8.0 Hz, 2H), 6.87 (d, J =8.2 Hz, 1H), 5.20 (5, 2H), 3.37(,J=0.6 Hz, 3H), 1.15 (d, / = 6.9 Hz, 6H). INTERMEDIATE C1 Synthesis of methyl 2-{4-(3-bromo-2-fluoro-4-hydroxybenzyl)-3,5-dimethylphenoxy)acetate Intermediate C1 F Br. i : HO oy 0 C1 A solution of Intermediate A3 {1 g, 4.12 mmol), 2-bromo-3-fluorophenol (2.3 8, 12.4 mmol) and ZnCl; (1M in THF, 10.3 mL) in DCE (5 mL) was stirred at 95°C overnight. The mixture was concentrated in vacuo and purified by silica gel column chromatography (pet. ether / EtOAc=5:1) and Prep-TLC (pet. ether / EtOAc=3:1) to afford Intermediate C1 (100 mg, 6.1% yield) as a colorless oil. TLC: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.4 1H NMR: (400 MHz, DMSQ-d6) 6 10.44 (s, 1H), 6.66 {s, 2H), 6.64 {d, J = 8.8 Hz, 1H), 6.37 (t, J = 8.4 Hz, 1H), 4.75 (s, 2H), 3.82 (s, 2H), 3.71 {s, 3H), 2.13 (s, 6H). INTERMEDIATE C2 Synthesis of ethyl 2-(3-bromo-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5- methylphenoxylacetate {Intermediate C2 F Br OTe 0 To a solution of Intermediate A6 (1.06 g, 3.3 mmol) in DCE (20 mL) at rt were added Intermediate B2 (1.52 g, 9.9 mmol) and ZnCl2 / THF (1M) (8.2 mL, 8.25 mmol). The reaction was heated to 85°C and stirred for 2h. The reaction mixture was diluted with DCM (20 mL), washed with brine (2 *10 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 5) to afford Intermediate C7 (530 mg, 38.8% yield) as a solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.35 IH NMR: {400 MHz, DMSO) 6 9.48 {d, J = 1.5 Hz, 1H), 7.08 (d, J = 2.7 Hz, 1H), 6.88 (d, J = 2.7 Hz, 1H), 6.49 — 6.43 (m, 1H), 6.17 {t, J = 8.6 Hz, 1H), 4.80 (s, 2H), 4.18 (d, J = 7.1 Hz, 2H), 3.93 (s, 2H), 2.16 {s, 2H), 1.26 (m, 6H), 1.17 (t, J = 7.1 Hz, 3H). INTERMEDIATE C3 Synthesis of ethyl 2-(4-(3-bromo-2-fluoro-4-hydroxybenzyl)-3,5-dichlorophenoxy)acetate Intermediate C3 F Cl rT ul “OO HO cl oO 0 C3 A solution of 2-bromo-3-fluorophenol (1.54 g, 8.07 mmol), Intermediate A11 (800 mg, 2.69 mmol) and ZnCl; (916 mg, 6.72 mmol) in DCE (20 mL) was stirred at 90°C overnight. The mixture was cooled to rt and concentrated in vacuo. Water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na,SOq, concentrated in vacuo and purified by silica gel column chromatography (pet. ether / EtOAc = 5 / 1) to afford Intermediate C3 (600 mg, 49.4% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5{(v / v), Rf=0.4 LCMS: RT=2.795 min, [M-1]= 448.9 1H NMR: (400 MHz, DMSO-d) § 10.55 {s, 1H), 7.18 (s, 2H), 6.68 (dd, J = 8.5, 1.4 Hz, 1H), 6.57 (t, J = 8.6 Hz, 1H), 4.89 (s, 2H), 4.18 (q, J = 7.1 Hz, 2H), 4.09 (s, 2H), 1.21 (t, J=17.1Hz, 3H). INTERMEDIATE C4 Synthesis of methyl 2-(4-(3-bromo-4-hydroxy-2-methylbenzyl)-3,5-dichlorophenoxy)acetate Intermediate C4 Cl wl Br. (J Oo HO cl oY ~ oO C4 To a solution of 2-bromo-3-methylphenol {1.0 g, 5.4 mmol) and Intermediate A10 (758 mg, 2.7 mmol) in DCE (10.0 mL) was added ZnCl, (1M / THF) (6.7 mmol, 6.7 mL). The mixture was stirred at 85°C overnight. The mixture was cooled to rt; water (20 mL) was added and the resultant mixture was extracted with DCM (10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SO4, concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether=1 / 30 to 1 / 10) to afford Intermediate C4 (400 mg, 34% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Ri=0.30 1H NMR: {400 MHz, DMSO-ds) § 9.94 (s, 1H), 7.20 (s, 2H), 6.65 (d, J = 8.4 Hz, 1H), 6.19 (d, J = 8.4 Hz, 1H), 4.93 (s, 2H), 4.05 (s, 2H), 3.72 (s, 3H), 2.45 (s, 3H). INTERMEDIATE C5 Synthesis of ethyl 2-(3-bromo-5-chloro-2-fluoro-4-(4-hydroxy-3- isopropylbenzyl)phenoxy)acetate (Intermediate C5’ Br or OIC o HO cl oY ~ oO [+1] To a solution of Intermediate A34 (1.0 g, 2.9 mmol) in DCE (10 mL) at rt were added 2-isopropylphenol (1.1 g, 8.3 mmol) and ZnCl; (6.9 mmol, 6.9 mL). The reaction was heated to 85°C and stirred overnight. The reaction mixture was cooled to rt; water (30 mL) was added and the resultant mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine (40 mL), dried over Na,SO, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100 to 1 / 10) to afford Intermediate C5 (550 mg, 43.1% yield) as a white solid. TLC: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.20 1H NMR: (400 MHz, DMSO-ds) § 9.11 (s, 1H), 7.44 (d, J = 7.6 Hz, 1H), 6.97 (s, 1H), 6.65 (d, = 1.2 Hz, 2H), 4.99 (s, 2H), 4.18 (q, J = 6.8 Hz, 2H), 4.11 (s, 2H), 3.13 (p, J = 6.8 Hz, 1H), 1.19 — 1.15 (m, 3H), 1.11 {(d, / = 6.8Hz, 6H). INTERMEDIATE C6 Synthesis of ethyl 2-(5-bromo-3-chloro-2-fluoro-4-(4-hydroxy-3- isopropylbenzyliphenoxylacetate (Intermediate C6’ Br Oe F 0 To a solution of Intermediate A39 (6.0 g, 16.7 mmol) in DCE (100 mL) at rt were added 2-isopropylphenol (6.8 g, 50.0 mmol) and ZnCl, (41.7 mmol, 42 mL). The reaction was heated to 85°C and stirred overnight. The reaction mixture was cooled to rt; water (60 mL) was added and the mixture was extracted with DCM {30 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 100 to 1 / 10) to afford Intermediate C6 (2.6 g, 33.9% yield) as a white solid. TLC: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.20 1H NMR: (400 MHz, DMSO-ds) § 9.13 (s, 1H), 7.54 (d, J = 7.6 Hz, 1H), 6.97 (s, 1H), 6.67 — 6.63 {m, 2H), 5.00 (s, 2H), 4.18 {(q, J = 7.2 Hz, 2H), 4.10 (s, 2H), 3.13 (p, / = 6.8 Hz, 1H), 1.21 {t, J= 7.2 Hz, 3H), 1.11 (d, J = 6.8 Hz, 6H). INTERMEDIATE C7 Synthesis of ethyl 2-(4-(3-bromo-2-fluoro-4-hydroxybenzyl}-3,5-dichloro-2- fluorophenoxy)acetate {Intermediate C7 F Cl 5 ol “XX F HO cl oN ON [eo] C7 To a solution of 2-bromo-3-fluorophenol (1.8 g, 9.3 mmol) and Intermediate A29 (1.0 g, 3.1 mmol) in chlorobenzene (20 mL) was added ZnCl, (1.0 g, 3.1 mmol). The mixture was stirred at 160°C in a microwave for 2h. The mixture was cooled to rt. Water (150 mL) was added and the resultant mixture was extracted with DCM (100 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SOs, concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether=1 / 5) to afford Intermediate C7 (950 mg, 67.7% yield) as a solid. TLC: EtOAc / pet. ether =1 / 5{v / v), Ri=0.25 1H NMR: (400 MHz, DMSO) 6 10.58 {s, 1H), 7.45 {d, J = 7.6 Hz, 1H), 6.69 (d, J = 8.7 Hz, 1H), 6.61 (d, J = 8.5 Hz, 1H), 5.02 (d, J = 6.8 Hz, 2H), 4.18 (d, J = 7.1 Hz, 2H), 4.11 (s, 2H), 1.21 (s, 3H). INTERMEDIATE C8 Synthesis of 3,5-dichloro-4-(3-isopropyl-4-(methoxymethoxy)benzyl)phenol (Intermediate C8! Cl MOMO : Cl OH C8 A solution of Intermediate B20 (8.2 g, 27 mmol) in THF (80 mL) was cooled down to -20°C. j-PrMgCl {1 M in THF, 32 mL) was added dropwise. The mixture was stirred at rt for 2 h and then cooled down to -70°C. A solution of Intermediate A74 (5.0 g, 18 mmol) in THF (10 mL) was added dropwise. The solution was stirred at -70°C for 2 h. Saturated NH.Cl aqueous (50 mL) was added and the mixture was extracted with EtOAc (50 mL*3). The combined organic phase was washed by brine (200 mL), dried over Na,SOs, concentrated in vacuum. The resulting brown oil was filtered through a plug of silica and the filtrate was concentrated. Half of the resulting yellow solid was dissolved in THF (30 mL) and Pd / C (750 mg, 6.18 mmol) was added. The mixture was stirred at 50°C under H, atmosphere overnight. The reaction was cooled to rt and filtered. Water (30 mL) was added and the mixture was extracted with EtOAc (20 mL*3). The combined organic phase was washed by brine (50 mL), dried over Na,SO4 and concentrated in vacuum. The resulting yellow oil was dissolved in DCM {20 mL), cooled to 0 °C and EtsSiH (3.60 g, 30.98 mmol) was added dropwise. TFA (1.4 g, 12.39 mmol) was then added dropwise. The mixture was stirred at rt for 0.5 h. The mixture was acidified to pH=7 with saturated aqueous NaHCO. The mixture was extracted with EtOAc (30 mL*2). The combined organic layer was washed with brine (50 mL), dried over Na;SO4 and concentrated in vacuum and purified by silica gel column (pet.ether / EtOAc=30 / 1 to 10 / 1) to afford Intermediate C8 (1.7 g, 80% yield) as yellow solid. 1H NMR: (400 MHz, DMSO-d) 6 10.24 {s, 1H), 7.06 (d, J = 2.2 Hz, 1H), 6.90 (d, J = 8.4 Hz, 1H), 6.88 (s, 2H), 6.79 (dd, J = 8.4, 2.3 Hz, 1H), 5.15 (s, 2H), 4.05 (s, 2H), 3.36 (s, 3H), 3.22 (p, J=7.0Hz, 1H), 1.13 (d, J = 6.9 Hz, 6H). INTERMEDIATE C9 Synthesis of 3,5-dichloro-2-iodo-4-(3-isopropyl-4-(methoxymethoxy)benzyl)phenol Intermediate CS Cl “OOK oo al OH co A solution of Intermediate C8 {1.6 g, 4.50 mmol) in DCM (30 mL) was cooled down to 0°C. NIS (912 mg, 4.05 mmol) was added in portion. The mixture was stirred at 0°C for 4 h. Water (30 mL) was added and the mixture was extracted with DCM (20 mL*3). The combined organic phase was washed by brine (50 mL), dried over Na,SQa, concentrated in vacuum and purified by silica gel column (pet. ether / EtOAc=50 / 1 to 5 / 1) to afford Intermediate C9 (200 mg, 9% yield) as a white solid. 14 NMR (400 MHz, DMSO-d) 6 11.12 {s, 1H), 7.06 {d, J = 2.3 Hz, 1H), 6.98 (s, 1H), 6.90 (d, J = 8.4 Hz, 1H), 6.75 (dd, J = 8.5, 2.3 Hz, 1H), 5.15 (s, 2H), 4.19 (s, 2H), 3.36 (s, 3H), 3.25 — 3.18 (m, 1H), 1.13 (d, / = 6.9 Hz, 6H). INTERMEDIATE C10 Synthesis of 2,4-dichloro-6-hydroxy-3-(3-isopropyl-4-(methoxymethoxy)benzyl)benzonitrile Intermediate C10 Cl “OC MOMO Cl OH To a mixture of Intermediate C9 (50 mg, 88 pmol), Pd(dba)s (10 mg, 18 pmol) and dppf (8 mg, 8 umol) in NMP (1 mL) was added Zn(CN); (21 mg, 176umol) . The mixture was heated to 150 °C and stirred for 1 h under microwave condition. The mixture was cooled down to rt. Water (20 mL) was added and the mixture was extracted with EtOAc (15 mL*3). The combined organic phase was washed by brine {30 mL), dried over Na;SO4 and purified by Prep-TLC (pet.ether / EtOAc=2 / 1) to afford Intermediate C10 (30 mg, 90% yield) as a white solid. 1H NMR (400 MHz, DMSO-d;) 6 12.01 {s, 1H), 7.10 (s, 1H), 7.06 (d, = 2.3 Hz, 1H), 6.91 (d, J = 8.4 Hz, 1H), 6.77 (dd, J = 8.4, 2.3 Hz, 1H), 5.16 (s, 2H), 4.11 (s, 2H), 3.36 (s, 3H), 3.26 — 3.18 (m, 1H), 1.14 (d, j= 7.0 Hz, GH). INTERMEDIATE D1 Synthesis of 2-bromo-4-(difluoromethoxy}-1-fluorobenzene (Intermediate D1 F LX No Br D1 A mixture of sodium chlorodifluoroacetate (1.0 g, 5.2mmol), 3-bromo-4- fluorophenol (1.60 g, 10.5 mmol) and K.CO3 (868 mg, 6.3 mmol) in DMF (10 mL) was stirred at 100°C for 2h. The mixture was cooled to rt. Concentrated HCl (1.5 ml) and water (3 mL) were added and the mixture was stirred at rt for 1h. The mixture was cooled to 0°C. NaOH (4M, 5 mL) and water (25 mL) were added, and the mixture was extracted with Et,0 (5 mL*3). The organic layer was washed with brine (15 ml), dried over Na,SO, and purified by silica gel column chromatography (pet. ether / EtOAc=200 / 1 to 100 / 1) to afford Intermediate D1 (150 mg, 11% yield) as a colorless oil. TLC: Pet. ether / EtOAc=100 / 1 {v / v), Rf=0.55 1H NMR: (400 MHz, DMSO-d) § 7.62 (dd, J = 6.0, 3.2 Hz, 1H), 7.46 (t, J = 8.8 Hz, 1H), 7.28 (dt, J = 9.2, 3.6 Hz, 1H), 7.24 (t, J = 73.6 Hz, 1H). 19F NMR: (376 MHz, DMSO-d) 5 -82.81, -112.84. INTERMEDIATE D2 Synthesis of 2-(5-{difluoromethoxy)-2-flucrophenyl}-4,4,5 5-tetramethyl-1,3,2-dioxaborolane Intermediate D2 Intermediate D2 F LAX No 8° o D2 To a mixture of Intermediate D1 {150 mg, 622 umol), bis(pinacolato)diboron {175 mg, 684 umol) and Pd{dppf)Cl,:CHCl; (25 mg, 31 umol) in 1,4-dioxane (5.0 mL) at rt was added potassium acetate (183 mg, 1.8 mmol). The mixture was heated to 110°C for 3h. The mixture was cooled to rt and filtered. The filtrate was concentrated in vacuo to afford crude Intermediate D2 (175 mg, 97% yield) which was used without further purification. TLC: EtOAc / pet. ether =1 / 10(v / v), Rf=0.65 EXAMPLE 1 Synthesis of methyl 2-(4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-3 5-dimethylphenoxy)acetate Compound 1 F @ . oO ad HO 0 1 To a solution of Intermediate B2 (381 mg, 2.3 mmol) and Intermediate A3 (200 mg, 0.78 mmol) in DCE (5.0 mL) was added ZnCl, (1M / THF) (1.9 mmol, 1.9 mL). The mixture was stirred at 85°C overnight. The mixture was cooled to rt; water (20 mL) was added and the resultant mixture was extracted with DCM {10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SO., concentrated in vacuo and purified by Prep-TLC (EtOAc / pet. ether=1 / 5) to afford Compound 1 (35 mg, 12% yield) as a light yellow oil. TLC: EtOAc / pet. ether =1 / 5(v / v), Ri=0.30 EXAMPLE 2 Synthesis of 2-{4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid Compound 2. F 0 oO 2 To a solution of Compound 1 (35 mg, 94 umol) in THF / H20 (2.0 mL / 0.5 mL) at rt was added LiOH-Hz0 (12 mg, 280 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (30 mL), acidified with 1N HCl to pH~3-4, and extracted with EtOAc (15 mL*3). The combined organic phase was washed with brine {30 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 2 (10 mg, 30% yield) as a white solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=4.025 min, [M-1] = 345.1 1H NMR: (400 MHz, DMSO-ds) § 9.43 (s, 1H), 6.62 (s, 2H), 6.43 (d, J = 8.4 Hz, 1H), 6.14 (d, J= 8.8 Hz, 1H), 4.62 (s, 2H), 3.74 {s, 2H), 2.11 (s, 6H), 1.26 (d, J = 7.0 Hz, 6H). EXAMPLE 3 Synthesis of 2-{4-((3'-{difluoromethoxy)-2-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)methyl)-3,5- dimethylphenoxy)acetic acid {Compound 3 3 F O F ITO OH HO oY 0 3 To a solution of Intermediate €1 (136 mg, 0.50 mmol) and Intermediate B3 (100 mg, 0.25 mmol) in 1,4-dioxane (4 mL) at rt were added Pd(dppf)Cl, (18 mg, 0.03 mmol) and NaHCO; (2N) (0.75 mmol, 0.4 mL). The reaction was heated under N, to 80°C overnight. LiOH.H20 (32 mg, 0.75 mmol) was added, and the mixture was stirred at rt for 30 min. The reaction mixture was diluted with EtOAc (10 mL), and the pH was adjusted to pH~4 with IN HCI. The aqueous layer was extracted with EtOAc (20 mL*2). The combined organic layer was washed with brine (20 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 3 (20 mg, 17.8% yield) as a white solid. TLC: DCM / MeQOH=10 / 1(v / v), Rf=0.2 LCMS: RT=3.752 min, [M-1] = 445.1 1H NMR: (400 MHz, DMSO-d6) 6 9.96 (s, 1H), 7.46 {d, J = 7.2 Hz, 1H), 7.27(d, J=0.4 Hz, 1H), 7.26(t, J=92.8, 1 H), 7.19 {s, 1H), 7.16 (d, J = 8.0 Hz, 1H), 6.65 (d, J = 80 Hz, 1H), 6.57 (s, 2H), 6.37 {t, J = 8.8 Hz, 1H), 4.25 (s, 2H), 3.79 (s, 2H), 2.13 (s, 6H). EXAMPLE 4 Synthesis of methyl 2-(4-(2-fluoro-3-(1-(4-fluorophenyl)vinyl)-4-hydroxybenzyl)-3,5- dimethylphenoxy)acetate (Compound 4! F F ol | ® oY “U0 0 4 A solution of Intermediate B5 (234 mg, 944 umol), Intermediate C1 (250 mg, 629 umol), Pd(dppf)Cl; (46 mg, 63 umol) and NaHCOs{aq) {2M, 1 mL) in 1,4-dioxane (5 mL) was stirred at 80°C overnight. The mixture was cooled to rt, and concentrated in vacuo. Water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na;S0s, concentrated in vacuo and purified by Prep-TLC (DCM / MeOH = 10 / 1) to afford Compound 4 {100 mg, 36.2% yield) as a yellow solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.55 EXAMPLE 5 Synthesis of 2-(4-(2-fluoro-3-(1-(4-fluorophenyl)vinyl)-4-hydroxybenzyl)-3,5- dimethylphenoxy)acetic acid {Compound 5 F F 3 on “0 0 5 A solution of Compound 4 {100 mg, 228 umol) and LiOH.H,0 (48 mg, 1.14 mmol) in water (1 mL) and methanol (3 mL) was stirred at rt for 1h. The mixture was acidified to pH~5 with IN HCI, water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na;SOa, concentrated in vacuo and purified by Prep-TLC (DCM / MeOH= 10 / 1) to afford Compound 5 {50 mg, 51.6% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5 {v / v}, R=0 1H NMR: (400 MHz, DMSO-d) & 9.48 (s, 1H), 7.60 — 7.45 (m, 3H), 7.32 (dd, J = 8.4, 5.5 Hz, 2H), 7.15 (t, J = 8.7 Hz, 2H), 6.62 {s, 2H), 6.56 (d, / = 8.6 Hz, 1H), 6.37 (t, J = 8.6 Hz, 1H), 5.97 {s, 1H), 5.23 (s, 1H), 4.57 (s, 2H), 3.77 (s, 2H), 2.15 (s, 6H). EXAMPLE 6 Synthesis of 2-(4-(2-fluoro-3-(1-(4-fluorophenyl)ethyl)-4-hydroxybenzyl)-3,5- dimethylphenoxy)acetic acid {Compound 6! F F Oe 0 8 A solution of Compound 5 {50 mg, 118 umol), and Pd / C (5%) (50 mg) in MeOH {5 mL) was stirred at 50°C under H; atmosphere overnight. The mixture was cooled to rt, filtered and concentrated in vacuo, then purified by Prep-HPLC to afford Compound 6 (20 mg, 39.8% vield) as a white solid. TIC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=2.264 min, [M-1] =425.1 1H NMR: (400 MHz, DMSO-ds) § 12.91 (s, 1H), 9.62 (s, 1H), 7.32 — 7.25 (m, 2H), 7.12 — 7.04 {m, 2H), 6.61 (s, 2H), 6.49 {d, = 8.4 Hz, 1H), 6.20 (t, J = 8.6 Hz, 1H), 4.60 (s, 3H), 3.71 (d, J = 4.6 Hz, 2H), 2.09 {s, 6H), 1.64 (dd, J = 7.4, 1.2 Hz, 3H). EXAMPLE 7 Synthesis of ethyl 2-(3-bromo-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5- methylphenoxy)acetate (Compound 7. F Br Fr or OTe 0 To a solution of Intermediate B2 (720 mg, 4.66 mmol) in DCE (5 mL) at rt were added Intermediate A6 (500 mg, 1.55 mmol) and ZnCl; in THF (3.11 mL of 1.0M, 3.11 mmol). The reaction was heated to 90°C overnight. The reaction mixture was diluted with DCM (20 mL), washed with brine (10 mL*2), dried over Na,SO,, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=10 / 1) to afford Compound 7 (250 mg, 36.6% yield) as a colorless oil. TL.C: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.21 IH NMR: {400 MHz, DMSO-d) 6 9.48 (s, 1H), 7.08 (d, J = 2.7 Hz, 1H), 6.88 (d, J = 2.7 Hz, 1H), 6.45 (d, J = 8.3 Hz, 1H), 6.17 (t, J = 8.6 Hz, 1H), 4.80 (s, 2H), 4.18 (q, J = 7.1 Hz, 2H), 3.93 (s, 2H), 3.38 (p, J = 7.1 Hz, 1H), 2.17 (s, 3H), 1.26 (d, J = 7.1 Hz, 6H), 1.24 — 1.18 {m, 3H). EXAMPLE 8 Synthesis of 2-(4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-3-methyl-5-vinylphenoxylacetic acid Compound 8 F > 2 ! C0. oO To a solution of Compound 7 {180 mg, 0.4 mmol) and vinyl boron(pinacolate) {92 mg, 0.6 mmol) in water (0.5 mL) / 1, 4-dioxane (3 mL) at rt were added Pd(dppf)Cl, (32 mg, 0.04 mmol) and K,CO3 (110 mg, 0.8 mmol). The reaction was heated to 120°C for 2h in a microwave. The mixture was cooled to rt and NaOH (48 mg, 1.2 mmol) was added. The mixture was stirred at rt for 0.5 h. The reaction mixture was diluted with EtOAc (10 mL), and filtered. The filtrate was acidified to pH~3-4 with 1N HCl, washed with water (5 mL*2), and brine (5 mL*2), dried over Na;SOq, and concentrated in vacuo. The crude product was purified by Prep-TLC (MeOH / DCM=1 / 10) to afford Compound 8 (146 mg, 99.4% yield) as a yellow oil. TLC: DCM / MeOH=1 / 10(v / v), Rf=0.24 EXAMPLE 9 Synthesis of 2-(3-ethyl-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-methylphenoxy)acetic acid Compound 8! F BOS CUP 0 To a solution of Compound 8 (146 mg, 0.4 mmol) in THF (3 mL) at rt was added Pd / C (50 mg); the mixture was stirred overnight at rt under H; atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated in vacuo and purified by Prep-HPLC to afford Compound 9 (70 mg, 48.6% yield) as a white solid. TLC: DCM / MeOH=10 / 1{v / v), Rf=0.48 LCMS: RT = 2.011 min, [M-1] = 359. IH NMR: {400 MHz, DMSO-ds) 6 9.41 (s, 1H), 6.62 (s, 2H), 6.43 (d, J = 8.3 Hz, 1H), 6.11 (t, 1=8.6 Hz, 1H), 4.61 (s, 2H), 3.76 {s, 2H), 3.47 — 3.34 (m, 1H), 2.45 (q, / = 8.3, 7.5 Hz, 3H), 2.10 (s, 3H), 1.27 {d, / = 7.2 Hz, 6H), 1.02 (t, J = 7.5 Hz, 3H). EXAMPLE 10 Synthesis of 2-(3-ethyl-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl}-5-methylphenoxy)-N- methylacetamide (Compound 10 F H NS 0 oY oC 0 10 To a solution of Compound 9 {50 mg, 0.14 mmol) in DCM (4 mL) at rt was added oxalyl chloride (18 mg, 0.14 mmol) and a drop of DMF (cat). The mixture was stirred at rt for 1h, then concentrated in vacuo. The crude acid chloride (50 mg, 0.14 mmol) was dissolved in THF (1 mLO and added dropwise to a solution of methylamine (12 mg, 0.39 mmol) in THF (3 mL) at 0 °C. The mixture was warmed to rt and stirred for 1h, then concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 10 (20 mg, 40.6% yield) as an off-white solid. TLC: MeOH / DCM=1 / 10 (v / v), Rf=0.68 1H NMR: {400 MHz, DMSO-d) 6 9.42 (s, 1H), 7.99 (s, 1H), 6.69 (q, J = 2.8 Hz, 1H), 6.61 (s, 1H), 6.42 (d, J = 8.4 Hz, 1H), 6.11 (t, J = 8.4 Hz, 1H), 4.56 {s, 1H), 4.42 (s, 1H), 3.76 {d, J = 3.6 Hz, 2H), 3.44 — 3.37 (m, 1H), 2.66 (d, J = 4.8 Hz, 2H), 2.45 (dd, J =7.6,5.2 Hz, 2H), 2.10 (d, J = 5.6 Hz, 3H), 1.27 (d, J = 7.2 Hz, 6H), 1.03 (td, J = 7.6, 4.8 Hz, 3H). 19F NMR: {376 MHz, DMSO-ds) 6 -120.54, -120.63. EXAMPLE 11 Synthesis of ethyl 2-(4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-3-methyl-5-(prop-1-en-2- yliphenoxy)acetate (Compound 11 FN I 0 OD) Oo “CL oY HO 0 11 To a solution of Intermediate €2 (530 mg, 1.21 mmol) in 1,4-dioxane (10 mL) at rt were added potassium isopropenyltrifluoroborate {357 mg, 2.42 mmol), Cs,CO3 (786 mg, 2.42 mmol) and Pd(dppf)Cl, (88 mg, 0.06 mmol). The reaction was stirred at 120°C under Na(g) in a microwave for 2h. The resulting solution of Compound 11 was used without further purification. TLC: EtOAc / pet.ether =1 / 5{v / v), Rf=0.35 LCMS: RT=3.26 min, [M-1] = 399.2 EXAMPLE 12 Synthesis of 2-{4-(2-fluoro-4-hydroxy-3-isopropylbenzyl}-3-methyl-5-{prop-1-en-2- yliphenoxy)acetic acid (Compound 12 FN OC. oO 12 To a solution of Compound 11 (500 mg, 1.25 mmol) in water (5 mL) / THF (1 mL) at rt was added NaOH (149 mg, 3.75 mmol); the resultant mixture was stirred at rt for 1h. The reaction was acidified to pH~3-4 with 2N HCl and extracted with DCM (30 mL*3). The combined organic phase was concentrated in vacuo and purified by Prep-HPLC to afford Compound 12 (330 mg, 70.9% yield). TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0 LCMS: RT=4.09 min, [M-1] =371.1 1H NMR: (400 MHz, DMSQ) 6 9.43 {s, 1H), 6.69 (d, J = 2.8 Hz, 1H), 6.51 (d, J = 2.7 Hz, 1H), 6.44 (d, J = 8.4 Hz, 1H), 6.15 (t, J = 8.6 Hz, 1H), 5.10 — 5.02 (m, 1H), 4.64 (d, J=2.3 Hz, 1H), 4.58 {s, 2H), 3.74 {s, 2H), 3.39 (s, 1H), 2.05 (s, 3H), 1.84 (s, 3H), 1.25(d, J = 7.1 Hz,6H). EXAMPLE 13 Synthesis of 2-{4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-3-isopropyl-5-methylphenoxyacetic acid {Compound 13 F ~~ oN" 0 13 To a solution of Compound 12 {270 mg, 0.72 mmol) in MeOH (5 mL) at rt was added Pd / C (27 mg), the mixture was stirred under H; atmosphere at 70°C for 16h. The reaction was cooled, filtered, concentrated and purified by Prep-HPLC to afford Compound 13 {100 mg, 37.1% yield). TLC: DCM / MeOH=20 / 1(v / v), Rf=0.35 LCMS: RT=4.16 min, [M-1] = 373.2 IH NMR: (400 MHz, DMSO) 6 12.88 (s, 1H), 9.42 (d, J = 1.4 Hz, 1H), 6.69 (d, J = 2.8 Hz, 1H), 6.60 (d, J = 2.7 Hz, 1H), 6.43 (d, J = 8.3 Hz, 1H), 6.11 (d, J = 8.6 Hz, 1H), 4.62 (s, 2H), 3.78 (s, 2H), 3.45 — 3.36 {m, 1H), 2.97 — 2.84 (m, 1H), 2.11 (s, 3H), 1.31 -1.24 {m, 6H), 1.05 {d, / = 6.8 Hz, 6H). EXAMPLE 14 Synthesis of methyl 2-(3,5-dichloro-4-{2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetate Compound 14 F Cl 5 wl . HO cl oY ~ oO 14 To a solution of Intermediate B2 (23.0 g, 149 mmol) and Intermediate A10 (15.0 8, 53 mmol) in DCE (300 mL) was added ZnCl; (1M in THF) (133 mmol, 133 mL). The mixture was stirred at 85°C overnight. The mixture was cooled to rt; water (150 mL) was added, and the resultant mixture was extracted with DCM {100 mL*3). The combined organic phase was washed with brine (100 mL), dried over Na,SO;, concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether=1 / 30 to 1 / 10) to afford Compound 14 (6.0 g, 28% yield) as a colorless ail. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.25 LCMS: RT=4.529 min; [M-1] = 398.9 1H NMR: {400 MHz, DMSO-d¢) 6 9.54 (s, 1H), 7.18 (s, 2H), 6.48 {d, J = 8.4 Hz, 1H), 6.27 (t, J1=8.4 Hz, 1H), 4.92 (s, 2H), 4.02 {s, 2H), 3.72 (s, 3H), 3.39 (m, 1H), 1.26 (d, / = 6.8 Hz, 6H). EXAMPLE 15 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 15 F Cl r ol ” HO cl oY [eo] 15 To a solution of Compound 14 {6.0 g, 15 mmol) in THF / H,0 (60 mL / 10 mL) at rt was added LiOH-Hz0 (1.9 g, 45 mmol). The mixture was stirred at rt for 1 h. The mixture was diluted with water {30 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (15 mL*3). The combined organic phase was washed with brine {30 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 15 (3.0g, 17% yield) as a white solid. TC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=3.974 min; [M-1] = 385.0 1H NMR: (400 MHz, DMSO-ds) § 13.14 (s, 1H), 9.54 (s, 1H), 7.14 (s, 2H), 6.48 (d, J = 8.4 Hz, 1H), 6.27 (t, J = 8.4 Hz, 1H), 4.79 (s, 2H), 4.02 (s, 2H), 3.40 (m, 1H), 1.26 (d, J =7.2 Hz, 6H). 19F NMR: (376 MHz, DMSO-ds) § -120.25. EXAMPLE 16 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N- methylacetamide (Compound 16 F Cl 5 wl q HO cl id ~ oO 16 To a mixture of Compound 15 (2.0 g, 5.2 mmol) in DCM (20 mL) was added DMF (cat). The mixture was cooled to 0°C and oxalyl chloride (1.3 g, 10.4 mmol) was added. The mixture was stirred at rt for 30 min, then concentrated in vacuo to afford the corresponding acid chloride (2.0 g, 95% yield) as a yellow solid. This material was dissolved in DCM (20 mL) and added dropwise to CH3NH, (2M / THF) (4.9 mL, 9.8 mmol). The mixture was stirred at rt for 1 h. Water (30 mL) was added and the resultant mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO4, concentrated in vacuo and purified by Prep-HPLC to afford Compound 16 (1.1 g, 55% yield) as a white solid. TLC: DCM / MeOH=10 / 1 (v / v), Rf=0.45 LCMS: RT = 3.974 min; [M-1] = 398.0 1H NMR: (400 MHz, DMSO-ds) § 9.54 (s, 1H), 8.09 (d, J = 4.4 Hz, 1H), 7.17 (s, 2H), 6.48 (d, J=8.4 Hz, 1H), 6.28 {t, J = 8.4 Hz, 1H), 4.56 (s, 2H), 4.03 (s, 2H), 3.41 (m, 1H), 2.67 (d, J = 4.4 Hz, 3H), 1.26 (d, J = 7.4 Hz, 6H). 19F NMR: {376 MHz, DMSO-d¢) 5 -120.23. EXAMPLE 17 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N,N- dimethylacetamide (Compound 17 F Cl 5 wl i HO cl oY ~ oO 417 To a mixture of Compound 15 (2.0 g, 5.2 mmol) in DCM (20 mL) was added DMF (cat). The mixture was cooled to 0°C and oxalyl chloride (1.3 g, 10.4 mmol) was added. The mixture was stirred at rt for 30 min, then concentrated in vacuo to afford the corresponding acid chloride (2.0 g, 95% yield) as a yellow solid. A sample of this material (150 mg, 370 umol) was dissolved in DCM (20 mL) and added dropwise to dimethylamine (2M / THF) (0.37 mL, 740 umol). The mixture was stirred at rt for 1h. Water (10 mL) was added and resultant mixture was extracted with DCM (10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SOq, concentrated in vacuo and purified by Prep- HPLC to afford Compound 17 {70 mg, 45% vield) as a white solid. TLC: DCM / MeOH=10 / 1 (v / v), Rf=0.45 LCMS: RT=4.109 min; [M-1] = 412.1 1H NMR: (400 MHz, DMSO-ds) § 9.52 (s, 1H), 7.12 (s, 2H), 6.48 (d, J = 8.4 Hz, 1H), 6.27 (t, J=8.6 Hz, 1H), 4.92 (s, 2H), 4.02 {s, 2H), 3.42 — 3.37 (m, 1H), 2.97 (s, 3H), 2.85 (s, 3H), 1.26 {d, / = 7.2 Hz, 6H). 19F NMR: {376 MHz, DMSO-d¢) 5 -120.28. EXAMPLE 18 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N- ethylacetamide (Compound 18' F Cl v ol q HO cl oY ~ Oo 18 To a solution of Compound 15 (70 mg, 181 umol) in DCM (2 mL) was added oxalyl chloride (69 mg, 542 umol). The mixture was stirred at rt for 1h. The mixture was concentrated in vacuo; ethylamine in THF {2 mL) was added, the mixture was stirred at rt for 10 min. The resultant solution was concentrated in vacuo and purified by Prep-TLC (DCM / MeOH = 10 / 1) to afford Compound 18 (40 mg, 56.3% yield) as a white solid. TLC: DCM / MeOH =10 / 1(v / v), Rf=0.56 LCMS: RT=2.545min, [M-1] = 412.1 *H NMR: (400 MHz, DMSO-ds) § 9.52 (d, J = 1.5 Hz, 1H), 8.14 (t, J = 5.7 Hz, 1H), 7.16 (s, 2H), 6.47 (d, J = 8.3 Hz, 1H), 6.27 (t, J = 8.6 Hz, 1H), 4.54 (5, 2H), 4.02 (s, 2H), 3.42 -3.35 (m, 1H), 3.20 - 3.10 (m, 2H), 1.26 {d, J = 7.2 Hz, 6H), 1.04 (t, J = 7.2 Hz, 3H). EXAMPLE 19 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N-ethyl-N- methylacetamide {Compound 19’ F Cl Fr ol : HO cl oY ~ 0 To a solution of Compound 15 (70 mg, 0.18 mmol) in DMF (3 mL) at rt were added HATU (103 mg, 0.27 mmol), DIEA (0.6mL, 0.36 mmol) and N-methyl-N-ethylamine (0.5 mL, 0.54 mmol). The mixture was stirred at rt for 2h, then diluted with water (10 mL) and extracted with EtOAc (3 mL*3). The combined organic phase was washed with brine (10 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 18 (27 mg, 35% vield) as an off-white solid. TL.C: DCM / MeOH=10 / 1 (v / v), Rf=0.7 IH NMR: {400 MHz, DMSO-ds) 6 9.56 — 9.50 {m, 1H), 7.10 (d, J = 3.2 Hz, 2H), 6.48 (dd, J = 8.4, 1.2 Hz, 1H), 6.27 {t, J = 8.4 Hz, 1H), 4.91 (d, J = 7.2 Hz, 2H), 4.01 (s, 2H), 3.40 (d, J = 7.2 Hz, 1H), 3.30 (dd, J = 7.6, 4.0 Hz, 2H), 2.95 (s, 1.5H), 2.82 (s, 1.5H), 1.33 = 1.20 (m, 6H), 1.14 {s, 1.5H), 1.01 (s, 1.5H). 19F NMR: {376 MHz, DMSO-d¢) 6 -73.97, -120.27. EXAMPLE 20 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyliphenoxy)-N-(2- fluoroethyl)acetamide {Compound 20’ F Cl Fr ol HO cl oY ~"E 0 20 To a solution of Compound 15 {100 mg, 258 umol) in DMF (5 mL) at rt were added HATU (147 mg, 387 umol), DIEA {67 mg, 516 umol} and 2-fluoroethylamine (77 mg, 775 umol). The mixture was stirred at rt for 2h, diluted with water (10 mL), and extracted with EtOAc (5 mL*3). The combined organic phase was washed with water (10 mL) and brine (10 mL), dried over Na;SOs, and concentrated in vacuo. The crude product was purified by Prep- TLC (MeOH / DCM=1 / 10) to afford Compound 20 (50 mg, 43% yield) as a white solid. TLC: DCM / MeOH =15 / 1(v / v), Rf=0.59 LCMS: RT=4.198 min, [M-1] = 430. 1H NMR: (400 MHz, DMSO-ds) § 9.52 (d, J = 1.5 Hz, 1H), 8.37 (t, J = 5.8 Hz, 1H), 7.17 (s, 2H), 6.47 (dd, J = 8.5, 1.1 Hz, 1H), 6.27 (t, J = 8.6 Hz, 1H), 4.60 {s, 2H), 4.52 (t, J =5.1Hz, 1H), 4.40 (t, J = 5.1 Hz, 1H), 4.02 {s, 2H), 3.48 (q, J = 5.3 Hz, 1H), 3.44 — 3.38 (m, 1H), 3.38 (s, 1H), 1.29 — 1.22 (m, 6H). EXAMPLE 21 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N- methoxyacetamide (Compound 21 F Cl Fr ol 4 HO cl oo” oO 21 To a solution of Compound 15 {70 mg, 181 umol) in DMF (3 mL) at rt were added HATU (103 mg, 271 umol), DIEA {47 mg, 362 umol} and methoxylamine {45 mg, 542 umol). The mixture was stirred at rt for 2h, diluted with water (10 mL), and extracted with EtOAc (5 mL*3). The combined organic phase was washed with water (10 mL*3) and brine (10 mL), dried over Na;SOs, and concentrated in vacuo. The crude product was purified by Prep- HPLC to afford Compound 21 {32 mg, 42% vield) as a white solid. TLC: DCM / MeOH =15 / 1(v / v), Rt=0.60 LCMS: RT=4.025 min, [M-1] = 414. 1H NMR: {400 MHz, DMSO-ds) 6 11.46 (s, 1H), 9.53 (s, 1H), 7.16 (s, 2H), 6.47 (d, / = 8.4 Hz, 1H), 6.26 (t, J = 8.6 Hz, 1H), 4.58 (s, 2H), 4.02 (s, 2H), 3.63 (s, 3H), 3.41 (s, 1H), 1.25 (d, J = 7.1 Hz, 6H). EXAMPLE 22 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl Jphenoxy)-N-methoxy-N- methylacetamide (Compound 22 F Cl v ol : HO cl oY 0” Oo 22 To a solution of Compound 15 (70 mg, 181 umol) in DMF (5 mL) at rt were added HATU (103 mg, 271 umol), DIEA (94 mg, 723 umol) and N,O-dimethylhydroxylamine (53 mg, 542 umol). The mixture was stirred at rt for 2h, diluted with water (10 mL), and extracted with EtOAc (5 mL*3). The combined organic phase was washed with water (10 mL*3) and brine (10 mL), dried over Na,S0,, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 22 (20 mg, 26% yield) as a white solid. TC: DCM / MeOH =15 / 1(v / v), Ri=0.55 LCMS: RT=4.394 min, [M-1] = 428. 1H NMR: (400 MHz, DMSO-ds) § 9.52 (d, J = 1.5 Hz, 1H), 7.12 (s, 2H), 6.48 (d, J = 8.4 Hz, 1H), 6.28 (t, J = 8.5 Hz, 1H), 5.01 {s, 2H), 4.02 (s, 2H), 3.75 (s, 3H), 3.42 - 3.37 {m, 1H), 3.13 (s, 3H), 1.29 —- 1.22 (m, 6H). EXAMPLE 23 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N',N'- dimethylacetohydrazide (Compound 23 F Cl Fr ol “OC R “a” HO cl oY N 0 To a solution of Compound 15 (70 mg, 181 umol) in DMF (5 mL) at rt were added HATU (103 mg, 271 umol), DIEA (94 mg, 723 umol) and N,N-dimethylhydrazine (52 mg, 542 umol). The mixture was stirred at rt for 2h, diluted with water (10 mL), and extracted with EtOAc (5 mL*3). The combined organic phase was washed with water (10 mL*3) and brine (10 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by Prep- HPLC to afford Compound 23 (12 mg, 15% vield) as a white solid. TL.C: DCM / MeOH =10 / 1(v / v), Rt=0.65 LCMS: RT=4.031 min, [M-1] = 427. 1H NMR: (400 MHz, DMSO-ds) § 9.52 (d, J = 1.5 Hz, 1H), 7.12 (s, 2H), 6.52 — 6.43 (m, 1H), 6.28 (t, J = 8.6 Hz, 1H), 5.01 (s, 2H), 4.02 (s, 2H), 3.75 (s, 3H), 3.41-3.33 (m, 1H), 3.13 (s, 3H), 1.26 {d, J = 7.1 Hz, 6H). EXAMPLE 24 Synthesis of 2-(3,5-dichloro-4-{{3'-(difluoromethoxy)-2-fluoro-6-hydroxy-[1,1'-biphenyl]-3- ylimethyliphenoxylacetic acid (Compound 24! AAA TO OH HO cl oY 0 24 A mixture of Intermediate A11 (150 mg, 0.34 mmol), Intermediate B3 (138 mg, 0.51 mmol), Pd(dppf)Cl, (22 mg, 0.03 mmol) and NaHCO3(2N) (0.51 mL, 1.02 mmol) in 1,4- dioxane (4 mL) was stirred at 85°C under N, overnight. LiOH.H,O (aqueous, 2M) (0.51 mL, 1.02 mmol) was added, and the mixture was stirred at rt for 1h. The solution was adjusted to pH~4 with IN HCl; the aqueous layer was extracted with EtOAc (20 mL*2). The organic layer was washed with brine (20 mL), dried over Na SO. and concentrated in vacuo. The residue was purified by Prep-HPLC (ACN / water=65:35, v / v) to afford Compound 24 (8 mg, 4.9% yield) as a white solid. TLC: DCM / MeQH=10 / 1(v / v), Rf=0.2 LCMS: RT=3.913 min, [M-1] = 485.0 1H NMR: {400 MHz, DMSO-ds) 6 10.04 {s, 1H), 7.48 — 7.45 {m, 1H), 7.28 (d, / = 4.4 Hz, 1H), 7.25(t, / =62.0Hz, 1 H), 7.19-7.15 (m, 2H), 6.95 (s, 2H), 6.70 (d, J = 8.6 Hz, 1H), 6.54 (t, J = 8.8 Hz, 1H), 4.26 (s, 2H), 4.06 (s, 2H). EXAMPLE 25 Synthesis of 2-(3,5-dichloro-4-((2,2'-difluoro-6-hydroxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3- ylimethyl}phenoxy)acetic acid (Compound 25’ E Cl | X TO OH HO cl oY 0 25 A mixture of 2-fluoro-5-trifluoromethylphenyl boronic acid (69 mg, 332 umol), Intermediate €3 (100 mg, 221 umol), K2CO3 (92 mg, 664 umol) and Pd(dppf)Cl; (16 mg, 22 umol) in 1,4-dioxane (2 mL) and water (0.5 mL) was stirred at 100°C overnight. The mixture was cooled to rt; LIOH.H.0 {28 mg, 664 umol) was added and the resultant mixture was stirred for 20 min. The mixture was acidified to pH~5 with 2N HCI; water. (30 mL) was added, and the mixture was extracted with EtOAc (25 mL*2). The combined organic layer was washed with brine (50 mL), dried over Na;SO., concentrated in vacuo and purified by Prep-HPLC to afford Compound 25 (20 mg, 17.8% vield) as a white solid. TLC: DCM / MeOH=10 / 1 (v / v), Rf=0.35 LCMS: RT=2.424 min, [M-1] = 504.9 IH NMR: (400 MHz, DMSO-ds) 6 13.10 (s, 1H), 10.08 (d, / = 1.7 Hz, 1H), 7.88 — 7.82 (m, 1H), 7.78 (dd, J = 6.4, 2.4 Hz, 1H), 7.56 (t, J = 9.0 Hz, 1H), 7.16 (s, 2H), 6.72 (d, J = 8.6 Hz, 1H), 6.65 (t, J = 8.6 Hz, 1H), 4.80 (s, 2H), 4.10 (s, 2H). EXAMPLE 26 Synthesis of 2-(3,5-dichloro-4-({5'-(difluoromethoxy)-2,2'-difluoro-6-hydroxy-[1,1'-biphenyl]-3- yl)methyliphenoxylacetic acid (Compound 26! F J YO HO cl yr" oO 28 A mixture of Intermediate €3 (50 mg, 111 umol), Intermediate D2 (96 mg, 332 umol), Pd(dppf)Cl, (8 mg, 11 umol) and K,CO; {46 mg, 332 umol) in water (0.3 mL) and 1,4- dioxane (2 mL) was microwaved at 140°C for 2h. The mixture was cooled to rt; LiOH.H,0 (14 mg, 331.8 umol) was added and the resultant mixture was stirred for 20 min. The mixture was acidified to pH~5 with 2N HCI; water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL *2). The combined organic phase was washed with brine (50 mL), dried over Na;SOs, concentrated in vacuo, and purified by Prep-TLC (DCM / MeOH = 10 / 1) and Prep-HPLC to afford Compound 26 (7 mg, 13.4 umol, 12.1% yield) as a white solid. TLC: DCM / MeOH =10 / 1(v / v), Rf=0.35 LCMS: RT=2.050 min, [M-1] =502.9 1H NMR: (400 MHz, DMSO-ds) 6 13.12 (s, 1H), 9.99 (d, J = 1.7 Hz, 1H), 7.36 (t, J = 9.0 Hz, 1H), 7.23 (t, J = 148.2 Hz, 1H), 7.28 — 7.19 (m, 2H), 7.16 (s, 2H), 6.70 (d, J = 8.6 Hz, 1H), 6.62 (t, J = 8.6 Hz, 1H), 4.80 {s, 2H), 4.09 (s, 2H). EXAMPLE 27 Synthesis of ethyl 2-(3,5-dichloro-4-(2-fluoro-3-(4-fluorobenzyl)-4- hydroxybenzyl)phenoxy)acetate {Compound 27 F F Cl IT FE Cl 0 HO cl oY ~ 0 27 To a solution of Intermediate B6 (444 mg, 2.02 mmol) in DCE (5 mL) at rt were added Intermediate A11 (200 mg, 0.67 mmol) and ZnCl; {1.0M in THF, 1.5 mL, 1.5 mmol). The reaction was heated to 90°C overnight. The reaction mixture was diluted with DCM (20 mL), washed with brine (10 mL*2), dried over Na;S0s, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=5 / 1) to afford Compound 27 (160 mg, 49.4% yield) as a colorless oil. TLC: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.21 1H NMR: (400 MHz, DMSO-ds) § 9.81 (s, 1H), 7.23 (dd, J = 8.5, 5.7 Hz, 2H), 7.16 (s, 2H), 7.11 -7.03 {m, 2H), 6.56 (d, J = 8.5 Hz, 1H), 6.40 (t, J = 8.7 Hz, 1H), 4.89 (s, 2H), 4.18 {q, 1 = 7.0 Hz, 3H), 4.04 (s, 2H), 3.88 {s, 2H), 1.23 — 1.18 (m, 3H). EXAMPLE 28 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-3-(4-fluorobenzyl)-4-hydroxybenzyl)phenoxy)acetic acid (Compound 28 F F Cl T F ol on HO cl oY 0 28 To a solution of Compound 27 (170 mg, 0.35 mmol) in THF (3 mL) / water (1 mL) at rt was added LiOH-H,O (18 mg, 0.42 mmol); the mixture was stirred at rt for 1h. The reaction was acidified to pH~3-4 with 1N HCI, then extracted with EtOAc (20 mL). The combined organic phase was washed with brine (20 mL), dried over Na,SOs, concentrated in vacuo and purified by Prep-HPLC followed by Prep-TLC (DCM / MeOH=5 / 1) to afford Compound 28 (25 mg, 15% yield) as a white solid. TLC: DCM / MeQH=5 / 1(v / v), Rf=0.31 LCMS: RT=4.137 min, [M-1] =451. 1H NMR: {400 MHz, DMSO-ds) 6 9.81 (s, 1H), 7.27 — 7.18 (m, 2H), 7.11 (s, 2H), 7.10 — 7.04 {m, 2H), 6.57 (d, / = 8.5 Hz, 1H), 6.40 (t, J = 8.7 Hz, 1H), 4.75 (s, 2H), 4.03 (s, 2H), 3.88 (s, 2H). EXAMPLE 29 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-3-(1-(4-fluorophenyl)vinyl)-4- hydroxybenzyliphenoxy)acetic acid (Compound 29' F F Cl I Ek wl OH HO cl oY 0 29 A solution of Intermediate B5 (494 mg, 1.99 mmol), Intermediate C3 (600 mg, 1.33 mmol), Pd(dppf)Cl (97.11 mg, 0.13 mmol) and NaHCO; {2 M, 2 mL) in 1,4-dioxane (7 mL) was stirred at 85°C overnight. The mixture was concentrated in vacuo. LIOH*H,0 (167 mg, 3.99 mmol) in THF / H:0 (5 mL / 1 mL) was added, and the mixture was stirred at rt for 2h. Water (30 mL) was added, the pH was adjusted to pH~5 with 2N HC, and the resultant mixture was extracted with EtOAc (25 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na,SOs, concentrated in vacuo and purified by Prep-TLC {DCM / MeOH = 5 / 1) to afford Compound 29 (200 mg, 32.4% vield) as a yellow solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=3.930 min, [M-1] = 463.0 EXAMPLE 30 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-3-{1-(4-fluorophenyl)ethyl)-4- hydroxybenzyliphenoxy)acetic acid (Compound 30' F F Cl T F ol OH HO cl oY 0 30 To a solution of Compound 28 {220 mg, 0.47 mmol) in methanol (5 mL) was added Pd / C (200 mg). The mixture was stirred at 60°C under H, atmosphere overnight. The mixture was filtered, concentrated in vacuo, and purified by Prep-HPLC to give Compound 30 (20 mg, 9.1% yield) as a yellow solid. TIC: MeOH / DCM =1 / 10(v / v), Rf=0.33 IH NMR: {400 MHz, DMSO-ds) 6 9.74 (s, 1H), 7.28 (dd, J = 8.5, 5.6 Hz, 2H), 7.15 - 7.03 (m, 4H), 6.53 (d, J = 8.4 Hz, 1H), 6.35 (t, J = 8.5 Hz, 1H), 4.76 (s, 2H), 4.60 (q, J = 7.3 Hz, 1H), 4.07 — 3.92 (m, 2H), 1.63 {d, / = 7.3 Hz, 3H). LCMS: RT=4.060 min, [M-1] = 465.0 EXAMPLE 31 Synthesis of ethyl 2-(3,5-dichloro-4-(2-fluoro-3-(1-{4-fluorophenyl)propyl)-4- hydroxybenzyl)phenoxy)acetate {Compound 31 F F Cl T Fk ol “X00 es oO 31 To a solution of Intermediate B8 (80 mg, 322 umol) in DCE (3 mL) at rt were added Intermediate A11 (32 mg, 107 umol) and ZnCl, (242 umol, 0.2 mL). The mixture was heated to reflux overnight. The mixture was diluted with DCM (5 mL), washed with brine (5 mL), dried over Na;S0s, and concentrated in vacuo. The crude product was purified by Prep- TLC (pet. ether / EtOAc=5 / 1) to afford Compound 31 (40 mg, 73% yield) as a colorless oil. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.36 EXAMPLE 32 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-3-(1-{4-fluorophenyl)propyl)-4- hydroxybenzyl)phenoxy)acetic acid {Compound 32 F F Cl T F Wl on HO cl oY fo} To a solution of Compound 31 (40 mg, 78.5 umol) in THF (5 mL) at rt was added LiOH.H,0 (10 mg, 236 umol) in water (1 mL). The mixture was stirred at rt for 2h, then diluted with water (10 mL), acidified with HCl (1N) to pH~3-4, and extracted with EtOAc (5 mL*3). The combined organic phase was washed with brine {10 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 32 (4 mg, 10% yield) as an off-white solid. TL.C: DCM / MeOH =10 / 1(v / v), Rt=0.39 LCMS: RT=2.906 min, [M-1] = 479. 1H NMR: (400 MHz, DMSO-ds) § 13.04 {s, 1H), 9.72 (s, 1H), 7.33 (dd, J = 8.5, 5.6 Hz, 2H), 7.12 {s, 2H), 7.11 - 7.05 (m, 2H), 6.52 {d, J = 8.4 Hz, 1H), 6.35 (t, J = 8.5 Hz, 1H), 4.76 (s, 2H), 4.33 {t, J = 8.0 Hz, 1H), 4.08 — 3.93 (m, 2H), 2.14 (dd, J = 13.5, 6.9 Hz, 2H), 0.83 (t, J = 7.3 Hz, 3H). EXAMPLE 33 Synthesis of ethyl 2-(3 5-dichloro-4-(2-fluoro-3-(1-(4-fluorophenyl)butyl)-4- hydroxybenzyl)phenoxy)acetate {Compound 33. F F Cl TF ul ~OT0 J oN ON oO 33 To a solution of Intermediate B10 {130 mg, 496 umol) in DCE (5 mL) at rt were added Intermediate A11 (50 mg, 165 umol) and ZnCl, (45 mg, 330 umol). The mixture was heated to reflux overnight. The mixture was diluted with DCM {5 mL), washed with brine (10 mL), dried over Na;50s, and concentrated in vacuo. The crude product was purified by Prep- TLC (pet. ether / EtOAc=5 / 1) to afford Compound 33 (40 mg, 46% vield) as a colorless ail. TLC: EtOAc / pet. ether =1 / 5(v / v), Ri=0.36 EXAMPLE 34 Synthesis of 2-(3,5-dichloro-4-(2-fluoro-3-{1-(4-fluorophenyl)butyl)-4- hydroxybenzyl)phenoxy)acetic acid {Compound 34) F F [i] TF Cl } HO cl oY i oO 34 To a solution of Compound 33 (40 mg, 76 umol) in THF (5 mL) at rt was added LiOH.H20 (10 mg, 229 umol) in water (1 mL). The mixture was stirred at rt for 2h, diluted with water (10 mL), acidified with HCI {1N) to pH~3-4, and extracted with EtOAc (5 mL*3). The combined organic phase was washed with brine (10 mL), dried over Na,SOs, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 34 (5 mg, 13% yield) as an off-white solid. TLC: DCM / MeOH =10 / 1(v / v), R=0.39 LCMS: RT=3.242 min, [M-1] = 493. 1H NMR: (400 MHz, DMSO-ds) § 9.72 (s, 1H), 7.34 (d, J = 8.2 Hz, 2H), 7.10 (d, J = 16.5 Hz, 4H), 6.52 (d, J = 8.6 Hz, 1H), 6.40 — 6.29 {m, 1H), 4.86 — 4.72 (m, 2H), 4.50 — 4.40 {m, 1H), 4.00 (s, 2H), 2.23 — 2.10 (m, 1H), 2.09 — 1.94 (m, 1H), 1.23 (s, 2H), 0.88 {t, J = 7.5 Hz, 3H). EXAMPLE 35 Synthesis of ethyl 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5- methylphenoxylacetate (Compound 35 F Cl v wl 0 NO Oo 35 To a solution of Intermediate A14 (1.0 g, 2.21 mmol) in DCE (5 mL) at rt were added Intermediate B2 (0.6 g, 1.47 mmol) and ZnCl; (4.32 mL, 4.32 mmol). The mixture was heated to reflux overnight. The mixture was diluted with DCM (5 mL), washed with brine (5 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (pet. ether / EtOAc=20 / 1 to 5 / 1) to afford Compound 35 (320 mg, 37.5% vield) as a colorless oil. TLC: EtOAc / pet.ether =1 / 5{v / v), Rf=0.31 EXAMPLE 36 Synthesis of 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-methylphenoxy)acetic acid Compound 36 F Cl re ol OX oO 38 To a solution of Compound 35 (320 mg, 0.8 mmol) in THF (5 mL) at rt was added LiOH.H,0 (102 mg, 2.43 mmol) in water (1 mL). The mixture was stirred at rt for 2h, diluted with water (10 mL), acidified with HCl (1N) to pH~3-4, and extracted with EtOAc (5 mL*3). The combined organic phase was washed with brine (10 mL), dried over Na,SO,4, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 36 (80 mg, 27% yield) as an off-white solid. TLC: DCM / MeOH =10 / 1(v / v), Rf=0.39 LCMS: RT=3.974 min, [M-1] = 365. 1H NMR: (400 MHz, DMSO-d) § 9.62 (s, 1H), 6.79 (d, J = 2.6 Hz, 1H), 6.72 (d, J = 2.7 Hz, 1H), 6.47 (d, J = 8.4 Hz, 1H), 6.20 (t, J = 8.6 Hz, 1H), 4.36 (s, 2H), 3.88 (s, 2H), 3.45 -3.33 (m, 1H), 2.13 (s, 3H), 1.26 {d, J = 7.1 Hz, 6H). EXAMPLE 37 Synthesis of 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-methylphenoxy)-N- methylacetamide {Compound 37. F ol q HO oY o 37 To a solution of Compound 36 (60 mg, 164 umol) in DCM (3 mL) was cooled to 0°C. Oxalyl chloride (42 mg, 327 umol) and DMF (cat) were added. The mixture was stirred at rt for 1h, then concentrated in vacuo to give the crude acid chloride. One-third of this sample (20 mg, 52 umol) was dissolved in DCM {1 mL) and added dropwise to a solution of methylamine {1 mL) in DCM (3 mL) at 0°C. The mixture was stirred for 1h at rt, then concentrated in vacuo. The crude product was purified by Prep-TLC (DCM / MeOH=15 / 1) to afford Compound 37 (15 mg, 76% yield) as an off-white solid. LCMS: RT=3.969 min, [M-1] = 378. 1H NMR: (400 MHz, DMSO-d) 5 9.48 (s, 1H), 8.04 (s, 1H), 6.95 (s, 1H), 6.86 (s, 1H), 6.45 (d, J= 8.5 Hz, 1H), 6.20 (t, J = 8.8 Hz, 1H), 4.47 (s, 2H), 3.90 (s, 2H), 3.41 - 3.36 (m, 1H), 2.66 (d, J = 4.7 Hz, 3H), 2.17 (s, 3H), 1.26 (d, J = 7.1 Hz, 6H). EXAMPLE 38 Synthesis of 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-methylphenoxy)-N,N- dimethylacetamide (Compound 38' F Cl re wl ; HO oY ~ [eo] 38 To a solution of Compound 36 (60 mg, 164 umol) in DCM (3 mL) was cooled to 0°C. Oxalyl chloride (42 mg, 327 umol) and DMF (cat) were added. The mixture was stirred at rt for 1h, then concentrated in vacuo to give the crude acid chloride. One-third of this sample (25 mg, 65 umol) was dissolved in DCM {2 mL) and added dropwise to a solution of dimethylamine (1 mL) in DCM (3 mL) at 0°C. The mixture was stirred for 1h at rt, then concentrated in vacuo. The crude product was purified by Prep-TLC (DCM / MeOH=15 / 1) to afford Compound 38 (17 mg, 66.5% yield) as an off-white solid. LCMS: RT=3.974 min, [M-1] = 392. 1H NMR: (400 MHz, DMSO-d) § 9.03 (s, 1H), 6.89 (dd, J = 13.7, 2.4 Hz, 2H), 6.77 (d, J = 2.7 Hz, 1H), 6.63 (d, J = 8.2 Hz, 1H), 6.56 (dd, J = 8.2, 2.2 Hz, 1H), 4.66 (s, 2H), 3.93 (s, 2H), 3.16 — 3.09 (m, 1H), 2.19 {s, 3H), 1.10 (d, J = 6.9 Hz, 6H). EXAMPLE 39 Synthesis of ethyl 2-(3-bromo-5-chloro-4-(2-fluoro-4-hydroxy-3- isopropylbenzyl)phenoxy)acetate (Compound 39’ F Br Fk or Bo k > i 0 To a solution of Intermediate A17 (820 mg, 2.40 mmol) in DCE (30 mL) at rt were added Intermediate B2 (739 mg, 4.80 mmol) and ZnCl;(s) (817 mg, 6.00 mmol). The reaction was heated to 90°C and stirred overnight. The reaction mixture was diluted with DCM (20 mL), washed with brine (20 mL}, dried over Na,SOq, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 50 to 1 / 10) to afford Compound 39 (600 mg, 54 % yield) as a colorless oil. TL.C: DCM / MeOH=5 / 1{v / v), Rf=0.24 LCMS: RT=3.341 min, [M-1] = 456.9. EXAMPLE 40 Synthesis of 2-(3-bromo-5-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 40 F Br 4 Br of > o C or Oo 40 To a mixture of Compound 39 (50 mg, 75% purity, 81.6 umol) in MeOH (3 mL) was added NaOH (10 mg, 245 umol) in water (1 mL). The mixture was stirred at rt for 10 min. The mixture was acidified to pH~5 with 2N HCl; water {10 mL) was added, and the resultant mixture was extracted with EtOAc {15 mL*2). The combined organic phase was washed with brine (50 mL), dried over Na,SO,, concentrated in vacuo, and purified by Prep-HPLC to afford Compound 40 (15 mg, 45.5% vield) as a white solid. TLC: EtOAc / pet. ether =1 / 5 {v / v), Re=0 LCMS: RT=2.372 min, [M-1] =428.9 1H NMR: (400 MHz, DMSO-ds) § 9.52 (d, J = 1.4 Hz, 1H), 7.28 (d, J = 2.6 Hz, 1H), 7.17 (d, J = 2.6 Hz, 1H), 6.47 (d, J = 8.3 Hz, 1H), 6.23 (t, J = 8.6 Hz, 1H), 4.79 (s, 2H), 4.06 (s, 2H), 3.42 — 3.37 (m, 1H), 1.26 (d, J = 7.1 Hz, 6H). EXAMPLE 41 Synthesis of ethyl 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5- vinylphenoxy)acetate (Compound 41 F N 2 | I Ce 0 41 To a mixture of Compound 39 (600 mg, 1.31 mmol) and vinyl boron{pinacolate) (302 mg, 1.96 mmol) in water (1 mL) / 1,4-dioxane (3 mL) at rt were added Pd(dppf)Cl; (106 mg, 0.13 mmol) and Cs,COs (850 mg, 2.62 mmol) under N,(g). The reaction was microwaved at 120°C for 2h. The mixture was diluted with EtOAc (20 mL*2), washed with brine (20 mL), dried over Na,5Os, and concentrated in vacuo to afford Compound 41, which was used without further purification. TLC: pet. ether / EtOAc=5 / 1{(v / v), Rf=0.50 LCMS: RT= 2.385 min, [M-1] = 405.0. EXAMPLE 42 Synthesis of 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl}-5-vinylphenoxy)acetic acid Compound 42 F = i I JOC. oO To a solution of Compound 41 (500 mg, 1.23 mmol) in MeOH (5 mL) / water (1 mL) at rt was added LiOH-H,0 (155 mg, 3.69 mmol). The mixture was stirred at rt for 1h. Water (10 mL) was added, the mixture was adjusted to pH~3-4 with 1N HCl and extracted with EtOAc (10 mL*2). The combined organic phase was washed with brine (20 mL), dried over Na;SOs, concentrated in vacuo and purified by Prep-TLC (DCM / MeOH=3 / 1) to afford Compound 42 (220 mg, 47.3 % yield) as a colorless oil. TLC: pet. ether / EtOAc =5 / 1(v / v), Rf=0.02 LCMS: RT=1.812 min, [M-1] =377.1. EXAMPLE 43 Synthesis of 2-{3-chloro-5-ethyl-4-{2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 43 F 0. 0 43 To a solution of Compound 42 (50 mg, 0.13 mmol) in THF (5 mL) at rt was added Pd / C (10 mg); the resultant mixture was stirred at 60°C for 3h. The mixture was filtered, concentrated in vacuo and purified by Prep-HPLC to afford Compound 43 (20 mg, 39.6 % yield) as a white solid. TLC: DCM / MeQH=5 / 1(v / v), Rf=0.29 LCMS: RT= 2.388 min, [M-1] =379.1. 1H NMR: (400 MHz, DMSO-d) § 13.02 {s, 1H), 9.46 (d, J = 1.2 Hz, 1H), 6.90 (d, J = 2.4 Hz, 1H), 6.81 (d, J = 2.8 Hz, 1H), 6.45 (d, J = 8.4 Hz, 1H), 6.19 (t, J = 8.4 Hz, 1H), 4.71 (s, 2H), 3.92 (s, 2H), 3.39 (d, J = 7.2 Hz, 1H), 2.51 (d, / = 2.0 Hz, 2H), 1.26 (d, / = 7.2 Hz, 6H), 1.02 {t, J = 7.2 Hz, 3H). EXAMPLE 44 Synthesis of 2-(3-chloro-5-ethyl-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)phenoxy)-N- methylacetamide (Compound 44 F H O00 0 44 To a solution of Compound 43 {80 mg, 0.21 mmol) in DCM (5 mL) was added oxalyl chloride {40 mg, 0.32 mmol). The mixture was stirred at rt for 1h. The mixture was concentrated to dryness to afford the crude acid chloride (80 mg, 0.20 mmol), which was dissolved in DCM (5 mL) and added to CHsNH, / THF (2M, 2 mL). The mixture was stirred at rt for 30 min. The mixture was concentrated to dryness and purified by Prep-TLC {MeOH / DCM=1 / 15) to afford Compound 44 (21 mg, 26.0 % yield) as a white solid. TLC: Pet. ether / EtOAc=1 / 1(v / v), Rf=0.10 LCMS: RT= 0.873 min, [M-1] =392.1. IH NMR: {400 MHz, DMSO-ds) 6 9.52 (s, 1H), 8.08 (d, J = 5.2 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 6.87 (d, J = 2.8 Hz, 1H), 6.47 (d, J = 8.4 Hz, 1H), 6.18 (t, J = 8.4 Hz, 1H), 4.49 (s, 2H), 3.92 (s, 2H), 3.40 (s, 1H), 2.66 (d, J = 4.8 Hz, 3H), 1.26 (d, J = 7.2 Hz, 6H), 1.03 {t, J = 7.6 Hz, 3H). EXAMPLE 45 Synthesis of ethyl 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-(prop-1-en-2- yliphenoxy)acetate (Compound 45 FN on 1 Oe 0 45 A mixture of Compound 38 (1.0 g, 2.18 mmol), potassium isopropenyl trifluoroborate (805 mg, 5.44 mmol), and Pd(dppf)Cl. (159.16 mg, 217.52 umol) in 1,4-dioxane (10 mL) and water (1 mL) was microwaved at 120°C for 2h. The mixture was cooled to rt, concentrated to dryness, and purified by silica gel column chromatography to afford Compound 45 (610 mg, 66.6% yield) as a white solid. TLC: EtOAc / pet. ether =1 / 5(v / v), Rf=0.39 1H NMR: {400 MHz, DMSO-d) 6 9.44 (s, 1H), 7.02 (d, J = 2.7 Hz, 1H), 6.74 (d, J = 2.7 Hz, 1H), 6.45 (d, J = 8.4 Hz, 1H), 6.19 (t, J = 8.6 Hz, 1H), 5.11 {t, J = 1.8 Hz, 1H), 4.84 (s, 2H), 4.68 {s, 1H), 4.18 (q, J = 7.1 Hz, 2H), 3.87 (s, 2H), 3.43 — 3.32 (m, 11H), 1.83 (s, 3H), 1.25 (d, J = 7.1 Hz, 6H), 1.21 (t, J = 7.1 Hz, 4H). EXAMPLE 46 Synthesis of 2-{3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl}-5-{prop-1-en-2- yliphenoxy)acetic acid (Compound 46 FN A 1 JOO 0 A mixture of Compound 45 (500 mg, 1.23 mmol) and NaOH (148 mg, 3.69 mmol) in water (1 mL) and THF (5 mL) was stirred at rt for 10 min. The mixture was acidified to pH~5 with 2M HCI, water (30 mL) was added, and the mixture was extracted with EtOAc (25 mL *2). The combined organic layer was washed with brine (50 mL), dried over Na,SOs, concentrated in vacuo and purified by Prep-HPLC to afford Compound 46 (15 mg, 3%) as an off-white solid. TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0 LCMS: RT=2.497 min, [M-1] =391.1 1H NMR: (400 MHz, DMSO-d) § 9.45 (s, 1H), 6.99 (d, J = 2.7 Hz, 1H), 6.72 (d, J = 2.7 Hz, 1H), 6.45 (d, J = 8.4 Hz, 1H), 6.20 (t, J = 8.6 Hz, 1H), 5.11 (t, J = 1.9 Hz, 1H), 4.73 (s, 2H), 4.68 {d, J = 1.7 Hz, 1H), 3.86 {s, 2H), 3.38-3.37 (m, 1H), 1.83 (s, 3H), 1.25 (d, J = 7.0 Hz, 6H). EXAMPLE 47 Synthesis of 2-(3-chloro-4-(2-fluoro-4-hydroxy-3-isopropylbenzyl)-5-isopropylphenoxylacetic acid {Compound 47 FY C0 oh 0 47 To a solution of Compound 46 {50 mg, 127 umol) in THF (5 mL) at rt was added Pd / C (10 mg); the resulting mixture was stirred at 55°C under 1 atm of H,(g) overnight. The reaction was filtered, concentrated in vacuo and purified by Prep-HPLC to afford Compound 47 (15 mg, 30% yield). TLC: DCM / MeOH=10 / 1(v / v), Rf=0.35 LCMS: RT=2.662 min, [M-1] = 393.1 1H NMR: (400 MHz, DMSO-d) § 13.05 (s, 1H), 9.48 (d, J = 1.4 Hz, 1H), 6.89 (d, J = 2.7 Hz, 1H), 6.86 (d, J = 2.7 Hz, 1H), 6.45 (d, J = 8.4 Hz, 1H), 6.18 (t, J = 8.6 Hz, 1H), 4.72 (s, 2H), 3.95 {s, 2H), 3.44 — 3.37 (m, 3H), 2.94 (p, J = 6.8 Hz, 1H), 1.26 (d, J = 7.0 Hz, 6H), 1.05 (d, J = 6.8 Hz, 6H). EXAMPLE 48 Synthesis of ethyl 2-(3,5-dichloro-4-(2-chloro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetate Compound 48 Cl Cl wl wl o HO cl oY ~ 0 48 To a solution of Intermediate B12 (300 mg, 1.74 mmol) and Intermediate A11 (174 mg, 0.58 mmol) in chlorobenzene (5 mL) was added ZnCl; (197 mg, 1.45 mmol). The mixture was stirred at 160°C under microwave irradiation for 2h. The mixture was cooled to rt; water (50 mL) was added and the resultant mixture was extracted with DCM (30 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na,SOq, concentrated in vacuo and purified by Prep-TLC (EtOAc / pet. ether=1 / 5) to afford Compound 48 (110 mg, 43% yield) as a colorless oil. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.25 LCMS: RT=2.60 min, [M-1] = 429.0 EXAMPLE 49 Synthesis of 2-(3,5-dichloro-4-(2-chloro-4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 49 Cl Cl wl wl = Ho cl oY oO 49 To a solution of Compound 48 (100 g, 0.23 mmol) in THF / H20 (1 mL / 5 mL) at rt was added LiOH-Hz0 (29 mg, 0.69 mmol). The mixture was stirred at rt for 1h. The mixture was diluted with water {10 mL), acidified with 1N HCI to pH~3-4, and extracted with EtOAc (15 mL*3). The combined organic phase was washed with brine {30 mL), dried over Na,SOs, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 49 (20 mg, 21% yield) as a white solid. TC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=4.42 min, [M-1] = 401.0 1H NMR: (400 MHz, DMSQ) 6 9.55 {s, 1H), 7.16 (s, 2H), 6.61 (d, J = 8.4 Hz, 1H), 6.12 (d, J = 8.4 Hz, 1H), 4.80 (s, 2H), 4.09 {s, 2H), 3.72 —3.57 (m, 1H), 1.32 (d, / = 7.0 Hz, 6H). EXAMPLE 50 Synthesis of methyl 2-(3,5-dichloro-4-(4-hydroxy-2-methyl-3-(prop-1-en-2- yl)benzyl)phenoxy)acetate {Compound 50 Cl oO HO cl oN ~ 0 To a mixture of Intermediate C4 (200 mg, 461 umol) and isopropenyl-2- boron(pinacolate) (155 mg, 922 umol) in 1,4-dioxane (2.0 mL) and H,0 (0.2 mL) at rt were added Pd(dppf)ClyCH:Cl; (41 mg, 46 umol) and K2COs (127 mg, 922 umol) under Ny(g). The reaction was heated to 70°C and stirred overnight. Water (20 mL) was added and the resultant mixture was extracted with EtOAc (10 mL *3). The combined organic phase was washed with brine (20 mL), dried over Na,SO., concentrated in vacuo and purified by Prep-TLC (pet. ether / EtOAc=5 / 1) to afford Compound 50 (40 mg, 22% yield) as a yellow oil. TLC: Pet. ether / EtOAc =5 / 1{v / v), Rf=0.32 EXAMPLE 51 Synthesis of methyl 2-(3,5-dichloro-4-(4-hydroxy-3-isopropyl-2-methylbenzyl)phenoxy)acetate Compound 51 4 wl 0 HO cl oN ~ 0 51 To a solution of Compound 50 {20 mg, 51 mmol) in THF (2.0 mL) was added Raney-Ni (cat.). The mixture was stirred at 70°C overnight under H; atmosphere. The mixture was cooled to 0°C and filtered, then concentrated in vacuo to afford Compound 51 (20 mg, 99% yield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5 (v / v), R=0.28 EXAMPLE 52 Synthesis of 2-(3,5-dichloro-4-(4-hydroxy-3-isopropyl-2-methylbenzyl)phenoxy)acetic acid Compound 52 Cl wl = Ho cl oY oO To a solution of Compound 51 (20 mg, 50 umol) in THF / H;0 (1.0 mL / 10 mL) at rt was added LiOH-Hz0 (7 mg, 150 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water {20 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine {20 mL), dried over Na,SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 52 (3 mg, 16% yield) as a white solid. TC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.836 min, [M-1] = 381.1 1H NMR: (400 MHz, DMSO-d) & 8.87 (s, 1H), 7.09 (s, 2H), 6.43 (d, J = 8.4 Hz, 1H), 5.97 (d, J= 8.4 Hz, 1H), 4.66 {s, 2H), 3.98 {s, 2H), 2.29 (s, 3H), 1.30 (d, J = 7.0 Hz, 6H). EXAMPLE 53 Synthesis of ethyl 2-(3,5-dichloro-4-(4-hydroxy-3-isopropyl-2-methoxybenzyl)phenoxylacetate Compound 53 Cl o” Y wl - es B 5 0 NON 0 To a solution of Intermediate B14 (200 mg, 0.70 mmol) in DCE (10 mL) at rt were added Intermediate A11 (352 mg, 2.12 mmol) and ZnCl; (1M in THF, 2 mL). The reaction was heated to 85°C and stirred overnight. The reaction mixture was diluted with DCM (20 mL), washed with brine (10 mL*2), dried over Na,SOy, filtered and concentrated in vacuo. The crude product was purified by Prep-TLC {EtOAc / pet. ether=1 / 5) to afford Compound 53 (50 mg, 17.1% yield) as a white solid. TL.C: Pet. ether / EtOAc=10 / 1(v / v), Rf=0.21 IH NMR: {400 MHz, DMSO-ds) 6 9.13 (s, 1H), 7.16 {s, 2H), 6.40 (d, J = 8.4 Hz, 1H), 6.06 (d, J = 8.4 Hz, 1H), 4.89 {s, 2H), 4.18 (q, J = 7.2 Hz, 2H), 4.05 (s, 2H), 3.70 (s, 3H), 3.38 -3.34 (m, 1H), 1.30 (d, J = 6.8 Hz, 6H), 1.21 {t, J = 7.2 Hz, 3H). EXAMPLE 54 Synthesis of 2-(3,5-dichloro-4-{4-hydroxy-3-isopropyl-2-methoxybenzyl)phenoxy)acetic acid Compound 54 Cl o” wv wl - > > oN! 0 54 To a solution of Compound 53 (50 mg, 0.12 mmol) in THF (5 mL) / water (0.2 mL) at rt was added LiOH-H0 (15 mg, 0.36 mmol); the resultant mixture was stirred at rt for 1h. The reaction was acidified to pH~6-7 with 2N HCl, concentrated in vacuo and purified by Prep-HPLC to afford Compound 54 (25 mg, 51.8% yield) as a white solid. TLC: DCM / MeOH=5 / 1(v / v), Rf=0.24 LCMS: RT=3.931 min, [M-1] =397.0. 1H NMR: (400 MHz, DMSO-d) 6 9.13 (s, 1H), 7.13 (s, 2H), 6.40 (d, J = 8.4 Hz, 1H), 6.07 (d, J= 8.4 Hz, 1H), 4.79 (s, 2H), 4.05 {s, 2H), 3.70 (s, 3H), 1.30 (d, J = 6.8 Hz, 6H). EXAMPLE 55 Synthesis of methyl 2-(3,5-dichloro-4-(2-cyano-4-hydroxy-3-isopropylbenzyl)phenoxy)acetate Compound 55 CN Cl CIN ol . HO cl oY ~ ) 55 A mixture of Intermediate B16 (150 mg, 0.93 mmol), Intermediate A10 (133 mg, 0.47 mmol), ZnCl; (160 mg, 1.18 mmol) and DCE (5 mL) was microwaved at 120°C for 2h. The mixture was cooled to rt and concentrated to dryness. Water (20 mL) was added, and the resultant mixture was extracted with EtOAc {15 mL *2). The combined organic layer was washed with brine (20 mL), dried over Na,SOq, and purified by Prep-TLC (pet. ether / EtOAc = 10 / 1) to afford Compound 55 (40 mg, 19.7% vield) as a white solid. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.25 EXAMPLE 56 Synthesis of 2-(3,5-dichloro-4-(2-cyano-4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 56 CN Cl CIN wl on HO cl oY 0 To a solution of Compound 55 (40 mg, 98 mmol) in THF / H,0 (5 mL / 1 mL) at rt was added LiOH-H,0 (12 mg, 294 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (10 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (15 mL*3). The combined organic phase was washed with brine {30 mL), dried over Na,SO4, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 56 (20 mg, 51.8% yield) as a white solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.824 min, [M-1] = 392.0 1H NMR: (400 MHz, DMSO-ds) § 13.14 {s, 1H), 9.92 (s, 1H), 7.17 (s, 2H), 6.96 (d, J = 8.5 Hz, 1H), 6.41 (d, J = 8.4 Hz, 1H), 4.81 (s, 2H), 4.22 (s, 2H), 3.48 — 3.42 (m, 1H), 1.36 (d, J = 7.1 Hz, 6H). EXAMPLE 57 Synthesis of ethyl 2-(2-fluoro-4-(4-hydroxy-3-isopropylbenzyl}-3,5-dimethylphenoxy)acetate Compound 57. r Oo JOC HO Oo 57 To a solution of Intermediate A24 (198 mg, 1.46 mmol) in DCE (10 mL) at rt were added 2-isopropyl phenol (200 mg, 0.73 mmol) and ZnCl; (1.82 mmol, 1.82 mL). The reaction was heated to 85°C for 4h. The reaction mixture was diluted with DCM (20 mL), washed with brine (10 mL*2), dried over Na;SO4, and concentrated in vacuo. The crude product was purified by Prep-TLC (EtOAc / pet. ether=1 / 3) to afford Compound 57 (170 mg, 62.3% yield) as a light yellow oil. TLC: EtOAc / pet. ether=1 / 10, Rf= 0.88 1H NMR: {400 MHz, DMSO-ds) 6 9.03 (s, 1H), 6.84 (d, J = 2.4 Hz, 1H), 6.78 (d, J = 8.8 Hz, 1H), 6.62 (d, J = 8.0 Hz, 1H), 6.45 (dd, J = 8.0, 2.0 Hz, 1H), 4.81 (s, 2H), 4.17 (q, J =7.2 Hz, 2H), 3.81 (s, 2H), 3.12 {(p, J = 6.8 Hz, 1H), 2.14 (s, 3H), 2.08 (d, J = 2.8 Hz, 3H), 1.20 (t, J = 7.2 Hz, 3H), 1.09 (d, J = 7.2 Hz, 6H). EXAMPLE 58 Synthesis of 2-(2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid Compound 58 “CC 10 or 0 To a solution of Compound 57 (170 mg, 0.45 mmol) in THF (5 mL) / water (0.5 mL) at rt was added LiOH.H,0 (39 mg, 0.91 mmol); the resultant mixture was stirred at rt for 1h. The reaction was diluted with water (20 mL), acidified to pH~3 with aqueous HCI (1N), and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (10 mL*2), dried over Na,SOq, and concentrated in vacuo. The crude product was purified by Prep- TLC (MeOH / DCM=1 / 8) to afford Compound 58 (157 mg, 96.8% yield) as a white solid. TLC: MeOH / DCM=1 / 10, Rf= 0.24 LCMS: RT=3.71 min; [M-1] = 345.1 1H NMR: (400 MHz, DMSO-d) § 9.09 (s, 1H), 6.86 (s, 1H), 6.73 — 6.57 (m, 2H), 6.43 (d, J =8.0 Hz, 1H), 4.43 (s, 2H), 3.78 (s, 2H), 3.12 {p, / = 6.8 Hz, 1H), 2.11 (s, 3H), 2.07 {s, 3H), 1.10 (d, / = 6.8 Hz, 6H). 19F NMR: {376 MHz, DMSO-d) 5 -140.89. EXAMPLE 59 Synthesis of 2-(2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)-N- methylacetamide (Compound 59 F H OCC x oO To solution of Compound 58 {150 mg, 0.43 mmol) in DCM (5 mL) at rt was added SOCI; (154 mg, 1.30 mmol); the resultant solution was stirred at rt for 3h. The reaction mixture was concentrated in vacuo to afford the acid chloride (157 mg, 99.3% yield) as a white solid. A sample of this material {70 mg, 0.19 mmol) was dissolved in DCM (2 mL), and added dropwise to a solution of methylamine (0.95 mmol, 0.95 mL of 1N aqueous solution) in THF (5 mL). The mixture was stirred overnight. The reaction mixture was diluted with water (20 mL) and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (10 mL*2), dried over Naz50s, and concentrated in vacuo. The crude product was purified by Prep- TLC (EtOAc / pet. ether=1 / 3) to afford Compound 58 (21 mg, 30.1% yield) as a white solid. LCMS: RT=3.68 min; [M-1]= 358.1 1H NMR: (400 MHz, DMSO-ds) § 9.03 (s, 1H), 7.94 (s, 1H), 6.85 (d, J = 2.4 Hz, 1H), 6.79 (d, J= 8.8 Hz, 1H), 6.62 {d, J = 8.4 Hz, 1H), 6.45 (dd, J = 8.4, 2.4 Hz, 1H), 4.49 (s, 2H), 3.81 (s, 2H), 3.12 {(p, / = 6.8 Hz, 1H), 2.65 (d, J = 4.8 Hz, 3H), 2.15 (s, 3H), 2.09 (d, J = 2.4 Hz, 3H), 1.10 (d, J = 6.8 Hz, 6H). 19F NMR: (376 MHz, DMSO-d) & -139.80. EXAMPLE 60 Synthesis of 2-(2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)-N,N- dimethylacetamide (Compound 60’ F OCC oO 680 To solution of Compound 58 {150 mg, 0.43 mmol) in DCM (5 mL) at rt was added SOCI; (154 mg, 1.30 mmol); the resultant solution was stirred at rt for 3h. The reaction mixture was concentrated in vacuo to afford the acid chloride (157 mg, 99.3% yield) as a white solid. A sample of this material (70 mg, 0.19 mmol) was dissolved in DCM (2 mL), and added dropwise to a solution of dimethylamine (0.95 mmol, 0.48 mL) in THF (5 mL). The mixture was stirred overnight. The reaction mixture was diluted with water (20 mL) and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (10 mL*2), dried over Na;SOs, and concentrated in vacuo. The crude product was purified by Prep-TLC (EtOAc / pet. ether=1 / 3) to afford Compound 60 {22 mg, 30.0% vield, 98.0% purity) as a white solid. LCMS: RT=3.76 min; [M-1] =372.2 1H NMR: (400 MHz, DMSO-d) § 9.02 (s, 1H), 6.85 (d, J = 2.0 Hz, 1H), 6.76 (d, J = 8.8 Hz, 1H), 6.62 (d, J = 8.0 Hz, 1H), 6.44 (dd, J = 8.0, 2.0 Hz, 1H), 4.83 (s, 2H), 3.80 (s, 2H), 3.11 (q, / = 6.8 Hz, 1H), 2.99 (s, 3H), 2.85 (s, 3H), 2.14 (s, 3H), 2.08 (d, J = 2.4 Hz, 3H), 1.10 {d, J = 6.8 Hz, 6H). 19F NMR: (376 MHz, DMSO-ds) & -140.69. EXAMPLE 61 Synthesis of ethyl 2-(3,5-dichloro-2-fluoro-4-{4-hydroxy-3-isopropylbenzyl)phenoxy)acetate Compound 61 Cl wl “OY o HO cl oY ~ oO 61 To a solution of Intermediate A29 (500 mg, 1.58 mmol) in DCE (5 mL) at rt were added 2-isopropylphenol (647 mg, 4.74 mmol) and ZnCl; (3.95 mL, 3.95 mmol). The reaction mixture was heated to 90°C and stirred for 16 h. The reaction mixture was diluted with DCM (20 mL), washed with brine {40 mL), dried over Na;SOs, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (EtOAc / pet. ether=1 / 8) to afford Compound 61 (377 mg, 57% yield) as a white solid. TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0.35 1H NMR: (400 MHz, DMSQ) 6 9.13 {s, 1H), 7.41 (d, J = 7.7 Hz, 1H), 6.99 — 6.96 (m, 1H), 6.70 — 6.61 (m, 2H), 5.00 (s, 2H), 4.17 {d, J = 7.1 Hz, 2H), 4.06 (s, 2H), 1.17 (s, 3H), 1.10 (d, J = 6.9 Hz, 6H). EXAMPLE 62 Synthesis of 2-(3,5-dichloro-2-fluoro-4-{4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 62 Cl wl “oo OH HO cl id 0 To a solution of Compound 61 (377 mg, 0.90 mmol) in water (10 mL) / THF (1 mL) at rt was added NaOH (108 mg, 2.70 mmol); the mixture was stirred at rt for 1h. The reaction mixture was acidified to pH~3-4 with 2N HCI, then extracted with DCM (40 mL*3); the combined organic phase was concentrated in vacuo and purified by reversed-phase column chromatography to afford Compound 62 {260 mg, 73 % yield). TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0 LCMS: RT = 2.78 min; [M-1] = 385.0 1H NMR: (400 MHz, DMSQ) 6 9.13 {s, 1H), 7.36 (d, J = 7.7 Hz, 1H), 6.98 (d, J = 1.9 Hz, 1H), 6.66 (t, J = 2.0 Hz, 2H), 4.89 {s, 2H), 4.06 (s, 2H), 3.13 (m, 1H), 1.10 (d, J = 6.9 Hz, 6H). EXAMPLE 63 Synthesis of 2-(3,5-dichloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)phenoxy)-N- methylacetamide (Compound 63. 2} wl F (JIC HO cl oY Ns 0 83 To a solution of Compound 62 (60 mg, 0.15 mmol) in DCM (5 mL) were added oxalyl chloride (57 mg, 0.45 mmol) and DMF (cat.). After stirring at rt for 1 h, the reaction was concentrated in vacuo. The residue was dissolved in DCM (5 mL) and was added to methylamine / THF solution (0.75 mL, 2.0M, 1.5 mmol). After stirring at room temperature for 1 h, the mixture was poured into water {20 mL) and extracted with DCM {30 mL*3); the organic phase was washed with brine (20 mL*2), dried over Na,SO,, concentrated in vacuo and purified by Prep-TLC (pet. ether: EtOAc=2:1) to afford Compound 63 (33 mg, 55% yield) as a white solid. TLC: DCM / MeOH=20 / 1(v / v), Rf=0.35 LCMS: RT = 3.84 min; [M+1] = 400.1 1H NMR: (400 MHz, DMSO) 6 9.13 {s, 1H), 8.02 (s, 1H), 7.29 (d, J = 7.6 Hz, 1H), 6.99 (d, J = 2.0 Hz, 1H), 6.65 (m, 2H), 4.67 (s, 2H), 4.06 (s, 2H), 3.12 (m, 1H), 2.64 (d, J = 4.6 Hz, 3H), 1.11 {d, / = 6.9 Hz, 6H). EXAMPLE 64 Synthesis of 2-(3,5-dichloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyliphenoxy)-N,N- dimethylacetamide {Compound 64. Cl ol 7 J HO cl oS 0 64 To a solution of Compound 62 (60 mg, 0.15 mmol) in DCM (5 mL) were added oxalyl chloride {57 mg, 0.45 mmol) and DMF (cat.). After stirring at rt for 1 h, the reaction was concentrated in vacuo. The residue was dissolved in DCM {5 mL} and was added to dimethylamine / THF (0.75 mL, 2.0M, 1.5 mmol) in DCM (5 mL). After stirring at room temperature for 1 h, the mixture was poured into water (20 mL) and extracted with DCM (30 mL*3); the organic phase was washed with brine (20 mL), concentrated in vacuo and purified by Prep-TLC {pet. ether: EtOAc=2:1) to afford Compound 64 (42 mg, 68% yield) as a white solid. TLC: DCM / MeOH=20 / 1{v / v), Rf=0.35 LCMS: RT = 3.97 min; [M-1] =412.1 1H NMR: (400 MHz, DMSQ) 6 9.13 (s, 1H), 7.32 (d, J = 7.8 Hz, 1H), 6.99 (d, J = 1.8 Hz, 1H), 6.66 (d, J = 2.7 Hz, 2H), 5.05 (s, 2H), 4.05 (s, 2H), 3.19 — 3.07 (m, 1H), 2.96 (s, 3H), 2.84 (s, 3H), 1.11 (d, J = 6.9 Hz, 6H). EXAMPLE 65 Synthesis of ethyl 2-(3-bromo-5-chloro-2-fluoro-4-(4-hydroxy-3- isopropylbenzyl)phenoxy)acetate (Compound 65 Br or YY o HO cl oY ~ oO 65 To a solution of Intermediate A34 (1.5 g, 4.2 mmol) and 2-isopropylphenol (1.7 8, 12.6 mmol) in DCE (20.0 mL) was added ZnCl (1M / THF) (10.4 mmol, 10.4 mL). The mixture was stirred at 85°C overnight. The mixture was cooled to rt; water (40 mL) was added and the resultant mixture was extracted with DCM (20 mL*3). The combined organic phase was washed with brine (30 mL), dried over Na,SO., concentrated in vacuo and purified by silica gel column chromatography (EtOAc / pet. ether=1 / 50 to 1 / 10) to afford Compound 65 (380 mg, 19.8% yield) as a light yellow oil. TLC: EtOAc / pet. ether =1 / 5({v / v), R=0.30 1H NMR: (400 MHz, DMSO-ds) § 9.11 (s, 1H), 7.44 (d, J = 7.8 Hz, 1H), 6.97 (s, 1H), 6.65 (d, J=1.2 Hz, 2H), 4.99 (s, 2H), 4.18 (d, J = 7.2 Hz, 2H), 4.11 (s, 2H), 3.12 (q, J = 6.9 Hz, 1H), 1.21 {t, J = 7.2 Hz, 3H), 1.11 (d, J = 6.8 Hz, 6H). EXAMPLE 66 Synthesis of ethyl 2-(5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3- vinylphenoxy)acetate (Compound 66 ~ I OC HO cl oO 0 To a mixture of Compound 65 (260 mg, 566 umol) and vinyl boron(pinacolate) (131 mg, 849 umol) in 1,4-dioxane (4.0 mL) and HO (0.5 mL) at rt were added Pd(dppf)ClyCH:Cl; (47 mg, 57 umol) and Cs2COs (369 mg, 1.1 mmol). The mixture was microwaved at 120°C under N,(g) for 3h. Water {20 mL) was added and the resultant mixture was extracted with EtOAc (10 mL *3). The combined organic phase was washed with brine (20 mL), dried over Na,SOq, concentrated in vacuo and purified by Prep-TLC (pet. ether / EtOAc=5 / 1) to afford Compound 66 (140 mg, 60.8% yield) as a yellow solid. TLC: Pet. ether / EtOAc =5 / 1{v / v), Rf=0.32 EXAMPLE 67 Synthesis of 2-(5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3-vinylphenoxy)acetic acid Compound 67 7“ I OC HO cl oN 0 87 To a solution of Compound 66 {20 mg, 50 umol) in THF / H,0 (2.0 mL / 0.5 mL) at rt was added LiOH-H,0 {12 mg, 294 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (20 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine (20 mL), dried over Na SOs and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 67 (8 mg, 21.6% yield) as a white solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.721 min, [M-1] =377.1 1H NMR: (400 MHz, DMSO-ds) § 9.07 (s, 1H), 7.18 (d, J = 8.0 Hz, 1H), 6.89 (d, J = 2.0 Hz, 1H), 6.68 — 6.58 {m, 2H), 6.56 (dd, J = 8.4, 2.4 Hz, 1H), 5.63 (d, J = 7.2 Hz, 1H), 5.59 (s, 1H), 4.81 (s, 2H), 3.98 (s, 2H), 3.13 (d, J= 7.2 Hz, 1H), 1.10 (d, J = 7.2 Hz, 6H). 19F NMR: {376 MHz, DMSO-d) 6 -137.31. EXAMPLE 68 Synthesis of ethyl 2-(5-chloro-3-ethyl-2-fluoro-4-{4-hydroxy-3- isopropylbenzyl)phenoxy)acetate (Compound 68 F JOC Or 0 To a solution of Compound 66 {100 mg, 246 umol) in THF (4.0 mL) was added Pd / C (10%) (50 mg). The mixture was purged three times with H;(g) and stirred at 60°C overnight. The mixture was cooled to 0°C and filtered, then concentrated in vacuo to afford Compound 68 (100 mg, 99% vield) as a yellow oil. TLC: EtOAc / pet. ether =1 / 5 {v / v), R=0.25 EXAMPLE 69 Synthesis of 2-(5-chloro-3-ethyl-2-fluoro-4-{4-hydroxy-3-isopropylbenzyl)phenoxy)acetic acid Compound 69 F COC OH 0 To a solution of Compound 68 (100 mg, 234 umol) in THF / H,0 (2.0 mL / 0.5 mL) at rt was added LiOH-H0O (30 mg, 702 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (20 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (10 mL*3). The combined organic phase was washed with brine {20 mL), dried over Na;SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 69 (30 mg, 32.3% yield) as a white solid. TL.C: MeOH, / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.747 min, [M-1] =379.0 1H NMR: (400 MHz, DMSO-d) § 9.06 (s, 1H), 7.11 (d, J = 8.0 Hz, 1H), 6.89 (d, J = 2.4 Hz, 1H), 6.64 (d, J = 8.4 Hz, 1H), 6.55 (dd, J = 8.2, 2.2 Hz, 1H), 4.82 (s, 2H), 3.98 (s, 2H), 3.16 — 3.10 {m, 1H), 2.59 (m, 2H), 1.10 {d, J = 6.8 Hz, 6H), 0.90 (t, J = 7.6 Hz, 3H). 19F NMR: (376 MHz, DMSO-d) & -139.73. EXAMPLE 70 Synthesis of ethyl 2-{5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl}-3-{prop-1-en-2- yliphenoxylacetate (Compound 70 ~~ 1 OCC HO cl oO Oo 70 To a mixture of Intermediate C5 (550 mg, 1.2 mmol) and potassium propenyl- 2-boron(trifluoride) (354 mg, 2.4 mmol) in 1,4-dioxane (5.0 mL) and H,0 (0.2 mL) at rt were added Pd(dppf)ClyCH,Cl, {98 mg, 120 umol) and Cs,CO3 {780 mg, 2.4 mmol) under N;(g). The reaction was heated to 120°C for 2h in a sealed tube. The mixture was cooled to rt; water (30 mL) was added and the resultant mixture was extracted with EtOAc (15 mL*3). The combined organic extracts were washed with brine {30 mL), dried over Na,S0,, concentrated in vacuo and purified by Prep-TLC (EtOAc / pet. ether=1 / 5) to afford Compound 70 (250 mg, 49.6 % yield) as a white solid. TLC: Pet. ether / EtOAc=5 / 1(v / v), Rf=0.23 1H NMR: (400 MHz, DMSO-ds) § 9.04 (s, 1H), 7.24 (d, J = 8.0 Hz, 1H), 6.77 (d, J = 2.4 Hz, 1H), 6.64 (d, J = 8.0 Hz,1H), 6.54 (dd, J = 8.4, 2.4 Hz, 1H), 5.31 (t, J = 1.6 Hz, 1H), 4.94 (s, 2H), 4.80 (t, J = 1.6 Hz, 1H), 3.91 (s, 2H), 3.13 (m, 1H), 1.76 (s, 3H), 1.21 (t, J = 7.2 Hz, 4H), 1.08 (d, J = 6.8 Hz, 6H). EXAMPLE 71 Synthesis of 2-(5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3-(prop-1-en-2- yliphenoxyacetic acid (Compound 71 ~~ 1 OX H HO cl oY ol 0 71 To a solution of Compound 70 (250 mg, 520 umol) in THF / H;0 (2.0 mL / 0.5 mL) at rt was added LiOH-H0 (39 mg, 930 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (50 mL), acidified with 1N HCI to pH~3-4, and extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine {50 mL), dried over Na;SO,, and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 71 (40 mg, 32.8 % yield) as a white solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.691 min, [M-1] =391.1 1H NMR: (400 MHz, DMSO-d) 6 9.05 (s, 1H), 7.18 (d, J = 8.0 Hz, 1H), 6.79 (d, J = 2.0 Hz, 1H), 6.63 (d, J = 8.0 Hz, 1H), 6.55 (dd, J = 8.0, 2.0 Hz, 1H), 5.31 (t, J = 2.0 Hz, 1H), 4.84 (s, 2H), 4.81 (t, J = 1.2 Hz, 1H), 3.91 (s, 2H), 3.16 — 3.10 (m, 1H), 1.77 (s, 3H), 1.09 {d, J = 6.8 Hz, 6H). 19F NMR: {376 MHz, DMSO-d) 6 -137.45. EXAMPLE 72 Synthesis of ethyl 2-(5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-3- isopropylphenoxylacetate (Compound 72 ~~ LF JOC Or 0 72 To a solution of Compound 70 {250 mg, 594 umol} in THF (6.0 mL) was added Pd / C {120 mg). The mixture was purged three times with H gas and stirred at 60°C overnight. The mixture was concentrated in vacuo to afford Compound 72 (220 mg, 87.6% yield) as a yellow oil. TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0.28 EXAMPLE 73 Synthesis of 2-{5-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl}-3-isopropylphenoxy)acetic acid {Compound 73 ~~ LF COC OH 0 To a solution of Compound 72 (250 mg, 520 umol) in THF / H,0 (2.0 mL / 0.5 mL) at rt was added LiOH-H0 (39 mg, 927 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (50 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine {50 mL), dried over Na;SO4 and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 73 (55 mg, 25.8% yield) as a white solid. TL.C: MeOH, / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.896 min, [M-1] =393.1 1H NMR: (400 MHz, DMSO-d) § 9.06 (s, 1H), 7.09 (d, J = 8.0 Hz, 1H), 6.82 (d, J = 2.0 Hz, 1H), 6.66 (d, J = 8.0 Hz, 1H), 6.59 (dd, J = 8.4, 2.4 Hz, 1H), 4.80 (s, 2H), 4.03 (s, 2H), 3.13 (m, 2H), 1.12 (dd, J = 7.2, 1.2 Hz, 6H), 1.09 (d, J = 7.2 Hz, 6H). 19F NMR: (376 MHz, DMSO-d) 5 -136.27. EXAMPLE 74 Synthesis of ethyl 2-(3-chloro-2-fluoro-4-{4-hydroxy-3-isopropylbenzyl)-5- vinylphenoxy)acetate {Compound 74. 7” 0 es F 0 74 To a mixture of Intermediate C6 (800 mg, 1.7 mmol) and vinylboron(pinacolate) (524 mg, 3.4 mmol) in 1,4-dioxane (6.0 mL) and water (0.5 mL) at rt were added Pd(dppf)ClyCH Cl; (139 mg, 170 umol) and Cs,CO3(1.1 g, 3.4 mmol). The reaction was heated to 120°C under Ny(g) in a sealed tube for 3h. The mixture was cooled to rt; water (50 mL) was added and the mixture was extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na,SO., concentrated in vacuo and purified by Prep-TLC (EtOAc / pet. ether=1 / 5) to afford Compound 74 (230 mg, 33.2 % yield) as a white solid. TLC: Pet. ether / EtOAc=5 / 1{v / v), Rf=0.17 1H NMR: (400 MHz, DMSO-ds) § 9.07 (s, 1H), 7.29 (d, J = 8.4 Hz, 1H), 6.92 — 6.90 (m, 1H), 6.62 (d, J = 8.0 Hz, 1H), 6.57 (dd, J = 8.4, 2.4 Hz, 1H), 5.34 (d, J = 10.8 Hz, 1H), 5.01 (s, 2H), 4.17 (q, J = 7.2 Hz, 2H), 4.04 (s, 2H), 3.12 (p, J = 6.8 Hz, 1H), 1.22 — 1.18 (t, J = 7.4 Hz, 3H), 1.09 (d, J = 6.8 Hz, 6H). EXAMPLE 75 Synthesis of 2-(3-chloro-2-fluoro-4-(4-hydroxy-3-isopropylbenzyl)-5-vinylphenoxy)acetic acid Compound 75 7“ I TOC OH F 0 75 To a solution of Compound 74 {100 mg, 246 umol) in THF / H,0 (2.0 mL / 0.5 mL) at rt was added LiOH-H,0 {30 mg, 738 umol). The mixture was stirred at rt for 1h. The mixture was diluted with water (30 mL), acidified with 1N HCI to pH~3-4 and extracted with EtOAc (20 mL*3). The combined organic phase was washed with brine (50 mL), dried over Na SOs and concentrated in vacuo. The crude product was purified by Prep-HPLC to afford Compound 75 (25 mg, 26.9% yield) as a white solid. TLC: MeOH / DCM =1 / 10(v / v), Rf=0.30 LCMS: RT=1.688 min, [M-1] =378.1 IH NMR: (400 MHz, DMSO-ds) 6 9.07 (s, 1H), 7.27 (d, J = 8.4 Hz, 1H), 6.97 — 6.88 (m, 2H), 6.63 (d, J = 8.0 Hz, 1H), 6.57 (dd, J = 8.4, 2.4 Hz, 1H), 5.76 (d, J = 17.2 Hz, 1H), 5.34 (d, = 11.2 Hz, 1H), 4.92 {s, 2H), 4.05 (s, 2H), 3.16 — 3.09 (m, 1H), 1.10 (d, J = 6.8 Hz, 6H). 19F NMR: {376 MHz, DMSO-d) 6 -133.28. EXAMPLE 76 Synthesis of ethyl 2-(3-chloro-5-ethyl-2-fluoro-4-{4-hydroxy-3- isopropylbenzyl)phenoxy)acetate (Compound 76’ O00 Or F Oo 76 To a solution of Compound 74 {130 mg, 320 umol) in THF (5.0 mL) was added Pd / C (50 mg). The mixture was stirred under H; atmosphere at 60°C overnight. The mixture was filtered and concentrated in vacuo to afford Compound 76 (130 mg, 99.2% yield) as a yellow oil. TLC: Pet. ether / EtOAc=1 / 5(v / v), Rf=0.28 EXAMPLE 77 Synthesis of 2-(3-c...

Claims

CLAIMS 1. A compound having the structure of Formula (1): v2 x1 “0X 0 A Cr CC 1 oN R! oq or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY agib ol dd -0 Rl R2 and R'° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R' taken together with the nitrogen atom to which they are attached form heterocycle; Ri¢is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; and R?is lower alkyl, lower alkenyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein R'?, R™, R¢, and R? are each, independently, optionally substituted with one or more halo, lower alkyl, lower haloalkyl, cyano, OR, -NR'R", =O, =S, -5(0)2R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

2. The compound of claim 1, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl optionally substituted with one or more halo, cyano, OR’, -NR'R", =0, =S, -5(0)2R" or -5(0),0R', wherein R'and R" are each, independently, H, lower alkyl, or lower haloalkyl.

3. The compound of claim 1 or claim 2, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is unsubstituted lower alkyl.

4. The compound of any one of claims 1-3, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is methyl, ethyl, propyl, or butyl.

5. The compound of any one of claims 1-4, having the structure of Formula (11): y2 x! H 0 A JO ’ oY iH ® om or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY agib ol dd -0 Rl R2 and R'° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, =NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein R%, R'®, and RX are each, independently, optionally substituted with one or more halo, cyano, -OR, =NR'R", =0, =5, =5(0)2R" or -5{0),OR', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

6. The compound of any one of claim 1-5 having the structure of Formula (I-A): v2 x! Ria = ”* \ “YY Rie | N. HO x2 oY Rb 0 (I-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; and R2 and R'° are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R® taken together with the nitrogen atom to which they are attached form heterocycle; wherein R!? and R™ are each, independently, optionally substituted with one or more halo, cyano, -OR, =NR'R", =0, =S, -5{0).R" or =S(0),OR', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

7. The compound of any one of claims 1-5, having the structure of Formula (II-B): v2 x! x » Y! SHY HO x oY R 0 (II-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; and Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; wherein Ri is optionally substituted with one or more halo, cyano, -OR), -NR'R", =0, =S, -S(0):R' or -S(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

8. The compound of claim 1, wherein R? is carbocyclealkyl or heterocyclealkyl and having the structure of Formula (III): v2 x1 d having the struct (RS}— A \ ~ TC o (my or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY agib ol dd -0 Rl Rand R™ are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Qis —C(R*R4)- or —{C(R3R*)},-; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R*, R™, R¢, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR', =NR'R", =O, =S, -5{0)2R" or =S(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

9. The compound of claim 1 or 8, having the structure of Formula (I11-A): v2 x1 rn a) Ria re A & Y! JIC Ur HO x2 oN Re o (I-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rand R™ are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Qis —C(R*R*)- or —{C(R3R%)},-; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR? -NRR®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NR?R?, ~NR3C(O)RE, -S{O):R?, or ~5{0),0R?®; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R22, R!°, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, =5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

10. The compound of claim 1 or 8 having the structure of Formula (III-B): v2 x1 10. The comj mn 1 H o A he y! oY o Il ~ Rc 0 (III-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ri¢is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Qis —C(R*R4)- or —{C(R3R*)},-; Ais aryl or heteroaryl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, ~OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®Rb, -NRC{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R, R?, R%, R%, R% and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =S, -5(0);R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

11. The compound of claim 1 having the structure of Formula (IV): Jy (Ro) n A 3 RS R4 : HO’ x1 OCC 1 oY R! ov or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY agib ol dd -0 Rl Rand R™ are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR°R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R*, R™, R¢, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR', -NR'R", =O, =S, -5{0)2R" or =S(0);0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

12. The compound of claim lor 11 having the structure of Formula (IV-A): y2 x1 iw TN A RS R* A Cl HO x1 x 2 ' hs | JAS By RP o (IV-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rand Rare each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R™°, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -S(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

13. The compound of claim 1 or 11 having the structure of Formula (IV-B): : TX (REA n A R® R* HO’ x! OC 1 oY T Oo. Rie 0 (IV-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR? -NRR®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R® and R%, together, form =0 or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NR?R?, ~NR3C(O)RE, -S{O)R?, or ~5{0),0R?®; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R, R?, R%, R%, R% and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, =5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

14. The compound of claim 1 having the structure of Formula (V): JPR X Qt QQ (Re) ~1 hy ; Ql J R?® R* : HO x! CCL 1 oY I R © v) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Ql, Q% Q3 Q% and Q° are each, independently, CH, CR®, or N; X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY agib ol dd -0 Rl Rand R™ are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, -NR®R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NReR?, ~NR2C(O)RE, -S{0);R?, or ~5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R™®, RI, R?, R*, RS, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, =NR'R", =O, =S, -S(0);R" or -S(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

15. The compound of claim 1 or 14 having the structure of Formula (V-A): ox Qt "y2 x1 Ria po Q?” Sat 5 er x ¥2 x! R? yi 1a 1 LAA Ho x2 oY RY 0 cettically accentahle icamer raremate hudrate calvate i © (v-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Ql, Q% Q3 Q% and Q° are each, independently, CH, CR®, or N; X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, ~NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R' taken together with the nitrogen atom to which they are attached form heterocycle; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R?, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NReR?, ~NR2C(O)RE, -S{0);R?, or ~5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R22, R!°, R?, R%, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, =5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

16. The compound of claim 1 or 14 having the structure of Formula (V-B): 2 Q* y2 x1 a 2” Saf 5 io I vox R? y! “100 oO. HO x2 0 Re o ceutically accentahle icamer raremate hudrate calvate i ° (v-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: Ql, Q% Q3 Q% and Q° are each, independently, CH, CR®, or N; X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ri¢is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, OR’, -NR'R", =O, =S, =S(O)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

17. The compound of claim 1 having the structure of Formula (VI): v2 x1 (re LJ R3. R* ! HO x! CC 1 oN 1 R o (v1) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY aglb ol r -0 Rl R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, ~NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R' taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R® and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, -OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R*?, R™®, R¢, R3, R4, R®, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR', =NR'R", =O, =S, -S(0);R" or -S(0),0R’, wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

18. The compound of claim 1 or 17 having the structure of Formula (VI-A): v2 x1 (RS LJ R3 R* = OD HO x1 Xx 2 i po | ji ji Rt o (VI-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, ~OR?, ~NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R' taken together with the nitrogen atom to which they are attached form heterocycle; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R™°, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -S(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

19. The compound of claim 1 or 17 having the structure of Formula (VI-B): v2 x1 G3 J R3 R* ! HO x! CIC 1 oY I o. Re 0 (VI-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; R? and R* are each, independently, H, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, ~OR?, -NR?R®, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, or R? and R¢, together, form =O or =S; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein RY, R?, R%, R®, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -S(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

20. The compound of claim 1 having the structure of Formula (VII): i v x (Rel A Y R! HO x2 oY o (vi or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis ~N| RY aglb ol r -0 Rl R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®Rb, -NRC{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R'°, R', RS, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

21. The compound of claim 1 or 20 having the structure of Formula (VII-A): v2 x! Ria (r 5 “In y2 : Y 0 x! A yt oO ~~ T “Rib o (VII-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rand Rare each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R?, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R2 and R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NR?R?, ~NR3C(O)RE, -S{O):R?, or ~5{0),0R?®; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R'2, RY, R%, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, =5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

22. The compound of claim 1 or 20 having the structure of Formula (VII-B): (Rs “OA y2 HO’ x! JL 1 oN 0 1 a’ Rlc 0 (VII-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Riis H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; Ais aryl or heteroaryl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R!°, RIS, RS, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR', -NR'R", =0, =5, =S(0).R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

23. The compound of claim 1 having the structure of Formula (VIII): "dy n Y2 J x! hod 1 oY Ih ® o (vin) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y* and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Rlis -N RY aRib o r -0 Rie R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, ~=NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, ~OR?, -NRR®, ~C(0)R?, -C(O)OR?, ~C(O)NR?R?, ~NR3C(O)RE, -S{O):R?, or ~5{0),0R?®; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R12, RY, RY, R%, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -S(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

24. The compound of claim 1 or 23 having the structure of Formula (VIII-A): y2 x1 Ra (RS 2g Y2 Be oO x! XC , oh N. Rt 0 (VIII-A) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; R2 and R'® are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, -OR?, -NR?R®, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or Rand R'® taken together with the nitrogen atom to which they are attached form heterocycle; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®Rb, -NRC{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R™®, R%, R?, and R® are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -5(0)R" or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

25. The compound of claim 1 or 23 having the structure of Formula (VII1-B): (re £) y2 HO’ x1 0 y! oy 0. TT Ric o (VIII-B) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein: X! is lower alkyl, lower alkenyl, lower haloalkyl, or halo; X? is lower alkyl, lower alkenyl, lower haloalkyl, or halo; Y! and Y? are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y! and Y? is not H; Ris H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; each R® is, independently, halo, cyano, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, carbocycle, heterocycle, carbocyclealkyl, heterocyclealkyl, -OR?, -NR°R®, -C(O)R?, -C(0)OR?, -C{O)NR®R?, -NR2C{O)R®, -S{0),R?, or -5{0),0R?; nis 0-5; and R? and RP are each, independently, H, lower alkyl, or lower haloalkyl; wherein R%, R!°, RIS, RS, R?, and RP are each, independently, optionally substituted with one or more halo, cyano, -OR’, -NR'R", =O, =5, -S(0)R' or -5(0),0R', wherein R' and R" are each, independently, H, lower alkyl, or lower haloalkyl.

26. The compound of any one of claims 8-25, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is H.

27. The compound of any one of claims 8-25, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R3 is carbocycle.

28. The compound of any one of claims 8-25 or 27, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R® is cyclopropyl or cyclobutyl.

29. The compound of any one of claims 8-25, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R3is lower alkyl.

30. The compound of any one of claims 8-25 or 29, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is methyl, ethyl, or propyl.

31. The compound of any one of claims 8-25, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is ~OR?.

32. The compound of claim 31, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is H.

33. The compound of any one of claims 1-32, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R® is lower alkyl.

34. The compound of claim 33, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R* is methyl.

35. The compound of any one of claims 1-34, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R* is H.

36. The compound of any one of claims 1-32, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein RX is H.

37. The compound of any one of claims 1-32, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R is lower alkyl.

38. The compound of claim 37, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein RX is methyl or ethyl.

39. The compound of any one of claims 1-38, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X! is lower alkyl.

40. The compound of any one of claims 1-39, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X! is methyl.

41. The compound of any one of claims 1-38, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is halo. 42, The compound of any one of claims 1-38 or 41, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is Cl or Br. 43, The compound of any one of claims 1-38, 41, or 42, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X!is Cl. 44, The compound of any one of claims 1-38, 41, or 42, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X!is Br. 45, The compound of any one of claims 1-38, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is lower haloalkyl.

46. The compound of any one of claims 1-38 or 45, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is CFs.

47. The compound of any one of claims 1-38, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X! is lower alkenyl.

48. The compound of any one of acclaims 1-38 or 47, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X* is vinyl or isopropenyl.

49. The compound of any one of claims 1-48, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower alkyl.

50. The compound of any one of claims 1-49, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is methyl.

51. The compound of any one of claims 1-48, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is halo.

52. The compound of any one of claims 1-48 or 51, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X2 is Cl or Br.

53. The compound of any one of claims 1-48, 51, or 52, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X2is Cl.

54. The compound of any one of claims 1-48, 51, or 52, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is Br.

55. The compound of any one of claims 1-48, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower haloalkyl.

56. The compound of any one of claims 1-48 or 55, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is CFs.

57. The compound of any one of claims 1-48, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is lower alkenyl.

58. The compound of any one of claims 1-48 or 57, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X? is vinyl or isopropenyl.

59. The compound of any one of claims 1-58, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower alkyl.

60. The compound of any one of claims 1-59, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower alkyl substitued with -OR'.

61. The compound of claim 60, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R'is H.

62. The compound of claim 60, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R' is lower alkyl.

63. The compound of any one of claims 1-62, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is lower haloalkyl.

64. The compound of any one of claims 1-63, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is =OR®.

65. The compound of claim 64, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl.

66. The compound of claim 64, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower haloalkyl.

67. The compound of any one of claims 1-66, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is -C(O)R?.

68. The compound of claim 67, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl.

69. The compound of any one of claims 1-68, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is ~NR3C(O)R®.

70. The compound of claim 69, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is H and RP is lower alkyl.

71. The compound of claim 70, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R® is methyl.

72. The compound of any one of claims 1-71, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is -C(O)OR?.

73. The compound of claim 72, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl.

74. The compound of claim 73, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is methyl or ethyl.

75. The compound of any one of claims 1-74, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is =S(0),R2.

76. The compound of claim 75, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is lower alkyl. 77: The compound of claim 76, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R? is methyl.

78. The compound of any one of claims 1-77, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is halo.

79. The compound of any one of claims 1-78, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is F.

80. The compound of any one of claims 1-79, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein at least one R® is cyano.

81. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is halogen.

82. The compound of any one of claims 1-81, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is F.

83. The compound of any one of claims 1-81, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y*is Cl.

84. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is cyano.

85. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is lower alkyl.

86. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is lower alkoxy.

87. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y!is H.

88. The compound of any one of claims 1-87, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is halogen.

89. The compound of any one of claims 1-88, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y? is F.

90. The compound of any one of claims 1-88, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2is Cl.

91. The compound of any one of claims 1-87, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is cyano.

92. The compound of any one of claims 1-87, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y? is lower alkyl.

93. The compound of any one of claims 1-87, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y2 is lower alkoxy.

94. The compound of any one of claims 1-87, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein YZ is H.

95. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is F and Y? isH.

96. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is Cl and Y? isH.

97. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is cyano and Y2is H.

98. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is lower alkyl and Y2is H.

99. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y! is lower alkoxy and Y2is H.

100. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y is H and Y? is F.

101. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y is H and Y? is Cl.

102. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y*is H and Y?is cyano.

103. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y*is H and Y? is lower alkyl.

104. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y'is H and Y?is lower alkoxy.

105. The compound of any one of claims 1-80, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein Y* is F and Y2 is F.

106. The compound of claim 1, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, having the structure of any one of the following compounds: F F F > '® TL oN OS | | HO oO F : gi: HO oY aN 1 HO” ~~ 7 7 “0” nope : HO oY oH 7 oO F F F IO +n JAF oN I Oo OO | oO e FN FP ® ! JOO 0 | A co OC | F ~ 0 F Br OT HO oY ox NF TTY HO” NF ~ br Det TOO, HO’ F ° Fog SN OC t | HO Cl F Fr Cl | | Ho cl 0 NOS | 0 | j | | HO” NF oF | - 0 ) 0 dd oH r ” 0 F IF Cl | HO cl oY oH | oO a no RL oT | | HO oN" oF a Oo ~~ oq 1 r Ul CTO, F | Ho cl oS | oO I OO, A HO J ® oy} 0 Cl NF ANF No NN | v end HO cl 0 fe F ~F | o Nl ! . fa | vo oO AAA oO Fr ul { HO cl oy oO F Cl F IC v ¥ ¥ } | HO cl oy F al I F C oO F Cl IT br ul JOC en AN a Foy HO ® A Ho | _ © ~r HO o 0 F or Io = Cl | | fi ; Ys HO cl oN Vo” SAA IA CL : t Z q FZ oN Vo” 0 @ O OH i ” HO cl oY F Cl LEV Cl r ol N F HO al oo” : ” F Cl ST F Cl | HO cl oy" F cl OIL HO Cl 0 N | it ff co o FY F al E Ld : [+o TOI po [® 8 VY OF cl LASS 3 cl | | Tr F Cl | HO cl og | OC Fe cl | Ad Tey Ho cl oN" I 6 0 FE F Fr cl ALLE 0 F cl | HO J cl ® oy oH I | SAA 0 ~ Fr ol | Ho cl oO | 0 F F Cl F cl ’ . MN An r Cl OO HO oN | OL 3 @ ® OH I HO cl oY CF Br 0 E FE Br i HO cl oO I 0 F cl 3 Br if Br | HO cl oN! 0 F F O F cl | HO cl oO | o F PY F FE cl IAA F A 00 HO cl oO A ogre FATA z = HO cl 0 | Y Ho cl oY oO A F 3 cl 1 F cl I | | ese i» 0 i" 0 oy | ° 0 F cl EF rv Ol | HO oN" IO y I © 0 F Cl F Cl i ’ ~ H HO oY | ey ~l ~~ N- oO 8 N HO cl oY ~| 0 ~~ F hd ol | | HO cl oO I HO al oN F NF 0” 0 0 NF 7 a F rr ou ul OT ne oi oN | HO cl oy 0 Cl oo” F SF CT F ~ © ol ! | ° - | HO cl oy Ho a oN I ° oO CN Cl Cl Cl none! We a oO HO cl oY o~ 1 Jil ha '® o o Cl Cl CN Cl Cl Cl CN Cl OO sens! Ho cl oN" Ho al oN" in S| oO oO Cl Cl 2 Or “OX HO a po I HO YY oO Cl ul ODO, WT | Ho cl 0 NOS | Ll oY 1 0 oO = Ned HO cl oY On OC | Ho ori | fo) 0 Z I “CC FE | Ho ’ : oN | “OCC 1 HO cl oN 0 1 Oo Cl Ce [eo] 7 OCC, Or oO Cl ol OCT | HO cl Ce oO OCC HO cl oY OH oO Cl Cl OC | Ho cl oN | oO : pens oO Cl ~ Cl OCC | Ho cl CE | 0 : JOC Br o Br v HO 7, ® a re Big 1 SS n ES 0 OCC oO ~~ ~~ { } OCC HO al oN" HO cl f oN | 1 - 0 a F 0 ~~ z OTe lee LOC Jor DOC om) F o F Oo F “ Cl ! ! | HO a oN! F 0 I Gl OCT HO cl oY oO oO F "100 | Ho cl oO F 0 Cl IO TI ul OC HO of ® oN ATI | HO cl oN! He ¢ ® 0 f I Y BE 0 F Cl AO F fo) F HO J, 2 oO | ~~ ] ’ F Cl 10 | Ho cl oN F 0 Y Cl ’ | HO cl oN! 0 r IA hen : HO a oN ON | “x X | Ho NF OCC | Ho oN | —— FE. 0 EAN al Ame | HO 7, @ oN" | | ANA XC | Ho a | Cl : fo IOC Ca ATA ot ALA oO Fr ol “OO HO cl oY Ong cl o ol OC 8: Ho a oN" | ANS oO » ol F ! HO cl a oH al o IO “XX gogo | pe oni o or H ev Cl E | | Ho cl oN Cl - [eo] HA AAA OC, Ag AN 2 aro | i 1 OK ] | Ho cl oN | ° La XX HO oO JX F 0 oo I ’ BD ig Cl cl . i Ho’ cl - pT ° Sep ed LATA, " ® ® oy I | Fo ~ of 0) on 0 mw = Ml 0 cS, 10 NEF cl 1 ~~ F cl ® : OC 0 LL € oY ~~ HO’ cl” NF oO XC - 0 F | F cl IC F Cl HO F r ol “OX HO’ NO | oO Tr Fr “i HO” >> ~~ ~~ OCC OH | F cl HO cl o : ~ CL 107 Na” ro” yr | v & © FE | HO oN! \ ) o | J F [] F Cl 2 [— H ite rh | - " J 1 OOO, TOC HO cl oy | | L 0 F EF 1 | OC. ~ i o | wo cl hf IO TT FE ol | OC : ~~ i HO cl oY | AS TY AY ° | HO al oN" F o F F Cl i abe. ok IC J F : | HO cl oY ~| EE I ; HO cl oy" | 3 0 ? FY Oo | HO oy al HO Cl 0 OC HO cl oN" oO Cl ol OCC Arn | IYI | Ho oY H] J oO F | Ho al oO | 0 F Cl F ul OC - rr H IL SA | ko ~AIYYYY oO XC oO CC a I PN oO II HO Cl Ol | HO oO | oO OCC PROB “| 0 SO r o “0 ~~ de 0 F SO F F ~ LX OH 0) A H Y HO of J oy YX _ ~ Ey J (Doi “Bd 0 = o FY _ E J BS CO pe oy Oe TI ~~ ~ FY r Sep OD - 0 E ~~ ~ F FT TOT Song TOT E F ; HO pM 0 FIT NJ F J CK HO F oY o H Ii oO FY Ii, STO cl FY F DOXA TI pn nL 0 F al F (J 0 HO cl ype HO cl YY 0 O00 pe | cl F 3 Ts ow | HO cl 0 Ne oY Y Cl Xp cl ® ® NH HO F oY F ) cl cl 5 J 2 Q oO | HO F oy 1 0 Oo i. of cl N “YY Co J N N OH HO cl oY F HO oY I I Z 0, HO cl oY TF F 0 x Aa HO cl oY F o Cl OL HO cl oN" 0 “J 4! { HO cl oN MS F o cl “IC HO cl oy" TID i WRT ~ cl 5 OX JK | Oo HE ” oy HO cl oY 0 ~ al 5 TIX, SBS | OH 5 & oy HO cl oY 0 H Zz cl | 0 OBOE: JA be HO 2 oN HO cl oY F 0 107. A pharmaceutical composition comprising a compound of any one of claims 1-106, or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, and a pharmaceutically acceptable excipient.

108. A method of treating a subject having a neurodegenerative disease comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically salt or composition thereof.

109. The method of claim 108, wherein the neurodegenerative disease is a demyelinating disease.

110. The method of claim 108 or 109, wherein the neurodegenerative disease is a chronic demyelinating disease.

111. The method of claim 108 or 109, wherein the neurodegenerative disease is X-linked genetic disorder, leukodystrophy, dementia, tauopathy, or ischaemic stroke.

112. The method of claim 108, wherein the neurodegenerative disease is multiple sclerosis, MCT8 deficiency, X-linked adrenoleukodystrophy (ALD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, frontotemporal dementia, or lacunar stroke.

113. The method of claim 108 or 109, wherein the neurodegenerative disease is adult Refsum disease, Alexander disease, Alzheimer's disease, Balo concentric sclerosis, Canavan disease, central pontine myelinolysis, cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy, Devic's syndrome, diffuse myelinoclastic sclerosis, idiopathic inflammatory demyelinating disease, infantile Refsum disease, Krabbe disease, Leber hereditary optic neuropathy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy, multifocal motor neuropathy, paraproteinemic demyelinating polyneuropathy, Pelizaeus-Merzbacher disease, peroneal muscular atrophy, progressive multifocal leukoencephalopathy, transverse myelitis, tropical spastic paraparesis, van der Knaap disease, X-linked adrenoleukodystrophy, or Zellweger syndrome.

114. A method of treating a subject having a medical condition associated with over-expression of TGF-B comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically salt or composition thereof.

115. The method of claim 114, wherein the medical condition associated with over-expression of TGF- is a fibrotic disease.

116. The method of claim 114 or 115, wherein the medical condition associated with over-expression of TGF-B is nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF), systemic scleroderma, or Alport syndrome.

117. A method of treating a subject having adult Refsum disease, infantile Refsum disease, Alexander disease, Alzheimer's disease, Balo concentric sclerosis, Canavan disease, central pontine myelinolysis (CPM), cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy (CIDP), Devic's syndrome, diffuse myelinoclastic sclerosis, encephalomyelitis, idiopathic inflammatory demyelinating disease (DD), Krabbe disease, Leber hereditary optic neuropathy, leukodystrophy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy (MLD), multifocal motor neuropathy (MMN), multiple sclerosis (MS), paraproteinemic demyelinating polyneuropathy, Pelizaeus-Merzbacher ~~ disease ~~ (PMD), progressive ~~ multifocal leukoencephaalopathy (PML), tropical spastic paraparesis (TSP), X-linked adrenoleukodystrophy (X-ALD, ALO, or X-linked ALO), Zellweger syndrome, MCT8 deficiency, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, lacunar stroke, primary age-related tauopathy (PART), Pick’s disease, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), adrenomyeloneuropathy (AMN), cerebral form of adrenoleukodystrophy (cALD), nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF), systemic scleroderma, or Alport syndrome, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

118. A method of treating a subject having NASH, NAFLD, NAFLD with hyperlipidemia, alcoholic liver fisease / alcoholic steatohepatitis, liver fibrosis associated with viral infection (HBV, HCV), fibrosis associated with cholestatic diseases (primary biliary cholangitis, primary sclerosing cholangitis), (familial) hypercholesterolemia, dyslipidemia, genetic lipid disorders, cirrhosis, alcohol-induced fibrosis, hemochromatosis, glycogen storage diseases, alpha-1 antitrypsin deficiency, autoimmune hepatitis, Wilson's disease, Crigler-Najjar Syndrome, lysosomal acid lipase deficiency, liver disease in cystic fibrosis, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

119. A method of treating a subject having Alport syndrome, diabetic nephropathy, FSGS, fibrosis associated with IgA nephropathy, chronic kidney diseases (CKD), post AKI, HIV associated CKD, chemotherapy induced CKD, CKD associated with nephrotoxic agents, nephrogenic systemic fibrosis, tubulointerstitial fibrosis, glomerulosclerosis, or polycystic kidney disease (PKD), the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

120. A method of treating a subject having IPF, ILD, pulmonary fibrosis, pulmonary fibrosis associated with autoimmune diseases like rheumatoid arthritis, scleroderma or Sjogren's syndrome, asthma-related pulmonary fibrosis, COPD, asbestos or silica induced PF, silicosis, respiratory bronchiolitis, Idiopathic interstitial pneumonias (lIP), Idiopathic nonspecific interstitial pneumonia, Respiratory bronchiolitis-interstitial lung disease, desquamative interstitial pneumonia, acute interstitial pneumonia, Rare IIPs: Idiopathic lymphoid interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, unclassifiable idiopathic interstitial pneumonias, hypersensitivity pneumonitis, radiation-induced lung injury, progressive massive fibrosis — pneumoconiosis, bronchiectasis, byssinosis, chronic respiratory disease, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary arterial hypertension (PAH), or Cystic fibrosis, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

121. A method of treating a subject having scleroderma / systemic sclerosis, graft versus host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutanea tarda, restrictive dermopathy, Dupuytren’s contracture, dermal fibrosis, nephrogenic systemic fibrosis / nephrogenic fibrosing dermopathy, mixed connective tissue disease, scleromyxedema, eosinophilic fasciitis, fibrosis caused by exposure to chemicals or physical agents. GvHD induced fibrosis, Scleredema adultorum, Lipodermatosclerosis, or Progeroid disorders (progeria, acrogeria, Werner's syndrome), the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

122. A method of treating a subject having atrial fibrosis, endomyocardial fibrosis, cardiac fibrosis, atherosclerosis, restenosis, or arthrofibrosis, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

123. A method of treating a subject having mediastinal fibrosis, myelofibrosis, post-polycythermia vera myelofibrosis, or post essential thrombocythemia, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

124. A method of treating a subject having Crohn's disease, retroperitoneal fibrosis, intestinal fibrosis, fibrosis in inflammatory bowel disease, ulcerative colitis, Gl fibrosis due to cystic fibrosis, or pancreatic fibrosis due to pancreatitis, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

125. A method of treating a subject having endometrial fibrosis, uterine fibroids, or Peyronie’s disease, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

126. A method of treating a subject having macular degeneration, diabetic retinopathy, retinal fibrovascular diseases, or vitreal retinopathy, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

127. A method of treating a subject having scarring associated with trauma, the method comprising administering to the subject in need thereof a pharmaceutically effective amount of the compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof.

128. The method of claim 127, wherein the scarring associated with trauma is associated with surgical complications, chemotherapeutics drug-induced fibrosis, or radiation induced fibrosis.

129. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of a neurodegenerative disease.

130. The compound of claim 129, wherein the neurodegenerative disease is a demyelinating disease.

131. The compound of claim 129 or 130, wherein the neurodegenerative disease is a chronic demyelinating disease.

132. The compound of claim 129 or 130, wherein the neurodegenerative disease is X-linked genetic disorder, leukodystrophy, dementia, tauopathy, or ischaemic stroke.

133. The compound of claim 132, wherein the neurodegenerative disease is multiple sclerosis, MCT8 deficiency, X-linked adrenoleukodystrophy (ALD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, frontotemporal dementia, or lacunar stroke.

134. The compound of claim 129 or 130, wherein the neurodegenerative disease is adult Refsum disease, Alexander disease, Alzheimer’s disease, Balo concentric sclerosis, Canavan disease, central pontine myelinolysis, cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy, Devic's syndrome, diffuse myelinoclastic sclerosis, idiopathic inflammatory demyelinating disease, infantile Refsum disease, Krabbe disease, Leber hereditary optic neuropathy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy, multifocal motor neuropathy, paraproteinemic demyelinating polyneuropathy, Pelizaeus-Merzbacher disease, peroneal muscular atrophy, progressive multifocal leukoencephalopathy, transverse myelitis, tropical spastic paraparesis, van der Knaap disease, X-linked adrenoleukodystrophy, or Zellweger syndrome.

135. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of a medical condition associated with over-expression of TGF-B.

136. The compound of claim 135, wherein the medical condition associated with over-expression of TGF-B is a fibrotic disease.

137. The compound of claim 135 or 136, wherein the medical condition associated with over-expression of TGF-B is nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF), systemic scleroderma, or Alport syndrome.

138. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of adult Refsum disease, infantile Refsum disease, Alexander disease, Alzheimer's disease, Balo concentric sclerosis, Canavan disease, central pontine myelinolysis (CPM), cerebral palsy, cerebrotendineous xanthomatosis, chronic inflammatory demyelinating polyneuropathy (CIDP), Devic's syndrome, diffuse myelinoclastic sclerosis, encephalomyelitis, idiopathic inflammatory demyelinating disease (IIDD), Krabbe disease, Leber hereditary optic neuropathy, leukodystrophy, Marburg multiple sclerosis, Marchiafava-Bignami disease, metachromatic leukodystrophy (MLD), multifocal motor neuropathy (MMN), multiple sclerosis (MS), paraproteinemic demyelinating polyneuropathy, Pelizaeus-Merzbacher ~~ disease ~~ (PMD), progressive ~~ multifocal leukoencephaalopathy (PML), tropical spastic paraparesis (TSP), X-linked adrenoleukodystrophy (X-ALD, ALO, or X-linked ALO), Zellweger syndrome, MCT8 deficiency, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, lacunar stroke, primary age-related tauopathy (PART), Pick’s disease, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), adrenomyeloneuropathy (AMN), cerebral form of adrenoleukodystrophy (cALD), nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF), systemic scleroderma, or Alport syndrome.

139. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of NASH, NAFLD, NAFLD with hyperlipidemia, alcoholic liver fisease / alcoholic steatohepatitis, liver fibrosis associated with viral infection (HBV, HCV), fibrosis associated with cholestatic diseases (primary biliary cholangitis, primary sclerosing cholangitis), (familial) hypercholesterolemia, dyslipidemia, genetic lipid disorders, cirrhosis, alcohol-induced fibrosis, hemochromatosis, glycogen storage diseases, alpha-1 antitrypsin deficiency, autoimmune hepatitis, Wilson's disease, Crigler-Najjar Syndrome, lysosomal acid lipase deficiency, liver disease in cystic fibrosis.

140. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of Alport syndrome, diabetic nephropathy, FSGS, fibrosis associated with IgA nephropathy, chronic kidney diseases (CKD), post AKI, HIV associated CKD, chemotherapy induced CKD, CKD associated with nephrotoxic agents, nephrogenic systemic fibrosis, tubulointerstitial fibrosis, glomerulosclerosis, or polycystic kidney disease (PKD).

141. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of IPF, ILD, pulmonary fibrosis, pulmonary fibrosis associated with autoimmune diseases like rheumatoid arthritis, scleroderma or Sjogren's syndrome, asthma-related pulmonary fibrosis, COPD, asbestos or silica induced PF, silicosis, respiratory bronchiolitis, Idiopathic interstitial pneumonias (lIP), Idiopathic nonspecific interstitial pneumonia, Respiratory bronchiolitis-interstitial lung disease, desquamative interstitial pneumonia, acute interstitial pneumonia, Rare IPs: Idiopathic lymphoid interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, unclassifiable idiopathic interstitial pneumonias, hypersensitivity pneumonitis, radiation-induced lung injury, progressive massive fibrosis — pneumoconiosis, bronchiectasis, byssinosis, chronic respiratory disease, chronic obstructive pulmonary disease (COPD), emphysema, pulmonary arterial hypertension (PAH), or Cystic fibrosis.

142. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of scleroderma / systemic sclerosis, graft versus host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutanea tarda, restrictive dermopathy, Dupuytren’s contracture, dermal fibrosis, nephrogenic systemic fibrosis / nephrogenic fibrosing dermopathy, mixed connective tissue disease, scleromyxedema, eosinophilic fasciitis, fibrosis caused by exposure to chemicals or physical agents. GvHD induced fibrosis, Scleredema adultorum, Lipodermatosclerosis, or Progeroid disorders (progeria, acrogeria, Werner's syndrome).

143. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of atrial fibrosis, endomyocardial fibrosis, cardiac fibrosis, atherosclerosis, restenosis, or arthrofibrosis.

144. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of mediastinal fibrosis, myelofibrosis, post-polycythermia vera myelofibrosis, or post essential thrombocythemia.

145. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of Crohn's disease, retroperitoneal fibrosis, intestinal fibrosis, fibrosis in inflammatory bowel disease, ulcerative colitis, Gl fibrosis due to cystic fibrosis, or pancreatic fibrosis due to pancreatitis.

146. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of endometrial fibrosis, uterine fibroids, or Peyronie’s disease.

147. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of macular degeneration, diabetic retinopathy, retinal fibrovascular diseases, or vitreal retinopathy.

148. The compound of any one of claims 1-106, or a pharmaceutically acceptable salt or composition thereof, for use in the treatment of scarring associated with trauma.

149. The compound of claim 127, wherein the scarring associated with trauma is associated with surgical complications, chemotherapeutics drug-induced fibrosis, or radiation induced fibrosis.

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