System for assessing cell viability, cell membrane piercing and selecting a cell for microinjection
Large bore pipettes are used to measure cell resistance and capacitance, addressing the unreliability of existing methods, enabling accurate assessment of cell viability and membrane integrity through resistance threshold comparison, ensuring reliable cell health determination and successful injection.
AU2022330401B2Pending Publication Date: 2026-07-09AGM MEDICAL
Patent Information
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- AGM MEDICAL
- Filing Date
- 2022-08-18
- Publication Date
- 2026-07-09
Smart Images
Figure 00000001_0000 
Figure 00000044_0000 
Figure 00000045_0000
Abstract
Detection apparatus for testing biological cells, including a measuring means for measuring an electrical property of a single biological cell present in a solution, sampling means for sampling the solution, a membrane of the cell, and / or an intracellular fluid of the cell, and an electrically insulating component located between the sampling means and the measuring means, containing therein an electrically conductive material, where the electrically insulating component has resistance to an alkaline solution of pH 8 to 11, where the resistance to the alkaline solution includes resistance to formation of microcracks for at least 1 minute upon exposure to the alkaline solution, resistance to electrical insulation failure for at least 12 minutes upon exposure to the alkaline solution, and resistance to visible structural integrity failure for at least 20 minutes upon exposure to the alkaline solution.
Need to check novelty before this filing date? Find Prior Art