Parg inhibitory compounds

Abstract

The present invention relates to a compound of formula (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. The present invention further relates to the compound of formula (I) of the present invention for use in therapy. Instant compounds are particularly useful as PARC inhibitors, and can be used in a method of treatment of a proliferative disorder, preferably of cancer.

Description

Field of the invention The present invention relates to a compound of formula (I): R4 (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. The present invention further relates to the compound of formula (I) of the present invention for use in therapy. Instant compounds are particularly useful as PARG inhibitors, and can be used in a method of treatment of a proliferative disorder, preferably of cancer. Background of the invention Cancer is a leading cause of death worldwide. Although progression-free survival and overall survival of cancer patients has improved over the past two decades, millions of cancer patients still have few therapeutic options and poor survival outcomes (Jemal et al., J. Natl. Cancer Inst. 2017,109,1975). DNA replication stress (DRS) is a hallmark of cancer cells and a major source of genomic instability (a) Halazonetis et al., Science 2008,319,1352; b) Negrini et al., Nat. Rev. Mol. Cell Biol. 2010,11,220). In broad terms, DRS refers to the deregulation of DNA replication and cell cycle progression. DRS can be induced from endogenous or exogenous causes such as oncogene activation and chemotherapeutics, respectively (Zeman and Cimprich, Nat. Cell Biol. 2013,16, 2). At the level of the replication fork, DRS leads to replication fork stalling, disengagement of the replisome and eventually collapse. Several DNA repair proteins are involved in replication fork stability, protection, and restart under DRS conditions (a) Costantino et al., Science 2014,343,88; b) Scully et al., Curr. Opin. Genet. Dev. 2021 71,154). Poly(ADP)ribosylation (PARylation) is a transient and reversible post-translational modification that occurs at DNA damaged sites and is catalyzed by the poly (ADP-ribose) polymerase (PARP) family of proteins (Cohen and Chang, Nat. Chem. Biol. 2018,14,236). PARylation of various DNA repair proteins leads to their activation. Degradation of the poly(ADP) ribose chains is mediated primarily by the poly(ADP-ribose) glycohydrolase (PARG) protein. DNA damage dependent PARylation / dePARylation is a rapid and dynamic process which needs to be well regulated since imbalances between the two processes can lead to DNA damage. Human PARG encodes a 111 kDa protein of 976 amino acids. It contains a N-terminal regulatory domain, a catalytic domain and an ADP-ribose binding macrodomain. Five human PARG transcripts have been identified. Full length PARG is mostly nuclear; the smaller isoforms localize primarily to the cytoplasm. PARG functions primarily as an exo-hydrolase and it releases mainly mono(ADP-ribose) by hydrolyzing the a-O-glycosidic ribose-ribose bond in PAR. PARG can also act as an endo-hydrolase. PARG preferentially degrades long and linear PAR chains whereas its activity with small and branched PAR chains is significantly reduced (O’Sullivan et al., Nat. Commun. 2019,10,1182). Although PARG is the dominant cellular PAR degrading enzyme, it cannot act on the terminal protein-ribose bond. Additional hydrolases such as terminal ADP-ribose protein glycohydrolase (TARG1) and ADP-ribosylhydrolase 3 (ARH3) are also known to catalyze PAR-degradation. TARG1 and ARH3 complete the reversal of PARylation by removing protein-bound mono(ADP-ribose) moieties (a) Fontana et al., Elife 2017, doi: 10.7554 / eLife.28533; b) Rack et al., Genes Dev. 2020,34,263). TARG1 is located in the nucleus and cytoplasm. ARH3 is found primarily in the cytoplasm but it can also be found in the mitochondria and in the nucleus (Rack et al., Genes Dev. 2020,34,263). Genomic aberrations targeting tumor suppressor genes or oncogenes, often make cancer cells dependent on specific DNA repair pathways. For instance, it is well known that PARP inhibitors are particularly effective against tumors carrying mutations in the BRCA1 and BRCA2 genes (a) Bryant et al., Nature 2005,434,913; b) Farmer et al., Nature 2005, 434, 917). Targeting synthetic lethal interactions like the one between PARP and BRCA is an attractive novel therapeutic approach for cancer treatment. PARG participates in DNA replication and in various DNA repair mechanisms including singlestrand break (SSB) repair and replication fork restart. PARG inhibitors have shown synthetic lethal phenotype in cells with high levels of DRS caused by low expression of genes involved in DNA replication and / or replication fork stability (Pillay et al., Cancer Cell. 2019, 35, 519). Moreover, PARG inactivation, depletion or inhibition sensitizes cells to irradiation and to DNA damaging agents such as alkylating agents (e.g. temozolomide and methyl methanesulfonate) (a) Fujihara etal., Curr. Cancer Drug Targets 2009,9, 953; b) Gogola etal., Cancer Cell 2018,33,1078; c) Houl etal., Nat Commun. 2019,10,5654). Given the therapeutic potential of PARG inhibitors in cancer treatment, there is an increased need for the development of highly potent and selective PARG inhibitors beyond the ones that have already 2 been described (a) James et al., ACS Chem. Biol. 2016,11,3179; b) Waszkowycz et al., J. Med. Chem. 2018,61,10767). Certain compounds that are useful as PARG inhibitors are further disclosed in documents WO 2016 / 092326, WO 2016 / 097749 and WO 2021 / 055744. Document US 2019 / 233411 discloses certain Gcn2 inhibitors and uses thereof. Document WO 2009 / 050183 discloses certain imidazo[1,2-a]pyridine derivatives which are useful for treating diseases mediated by the ALK-5 and / or ALK-4 receptor. Summary of the invention It was an objective technical problem of the present invention to provide compounds that are cell -permeable inhibitors of PARG. The technical problem of the present invention is solved by the embodiments described herein and as characterized by the claims. Accordingly, in a first embodiment, the present invention provides a compound of formula (I): R4 (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. It is understood that thought the present description the term “a compound of formula (I)” preferably encompasses also a compound of formula (la) to (Ibo), unless indicated to the contrary. A further embodiment of the present invention relates to a pharmaceutical composition comprising the compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutically acceptable carrier. In a further embodiment, the present invention relates to the compound of formula (I) of the present invention or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition of the present invention, for use in therapy. The compounds of formula (I) are useful for treating a disease or disorder in which PARG activity is implicated. The compounds of formula (I) are useful for a method of treating a proliferative disorder. In a preferred embodiment of the present invention, the proliferative disorder is cancer, preferably a human cancer. Definitions The following definitions apply throughout the present specification and the claims, unless specifically indicated otherwise. The term “hydrogen” is herein used to refer to protium, deuterium and / or tritium, preferably to protium. Accordingly, the term “non-hydrogen atom” refers to any atoms that is not hydrogen, i.e. that is not protium, deuterium or tritium. The term “hydrocarbon group” refers to a group consisting of carbon atoms and hydrogen atoms. The term “alicyclic" is used in connection with cyclic groups and denotes that the corresponding cyclic group is non-aromatic. As used herein, the term “alkyl” refers to a monovalent saturated acyclic (i.e., non-cyclic) hydrocarbon group which may be linear or branched. Accordingly, an “alkyl” group does not comprise any carbon-to-carbon double bond or any carbon-to-carbon triple bond. A “C1-5 alkyl” denotes an alkyl group having 1 to 5 carbon atoms. Preferred exemplary alkyl groups are methyl, ethyl, propyl (e.g., n-propyl or isopropyl), or butyl (e.g., n-butyl, isobutyl, sec-butyl, or tert-butyl). Unless defined otherwise, the term “alkyl” preferably refers to Cm alkyl, more preferably to methyl or ethyl, and even more preferably to methyl. As used herein, the term “alkenyl” refers to a monovalent unsaturated acyclic hydrocarbon group which may be linear or branched and comprises one or more (e.g., one or two) carbon-to-carbon double bonds while it does not comprise any carbon-to-carbon triple bond. The term “C2-5 alkenyl” denotes an alkenyl group having 2 to 5 carbon atoms. Preferred exemplary alkenyl groups are ethenyl, propenyl (e.g., prop-1-en-1-yl, prop-1-en-2-yl, or prop-2-en-1-yl), butenyl, butadienyl (e.g., buta-1,3-dien-1-yl or buta-1,3-dien-2-yl), pentenyl, or pentadienyl (e.g., isoprenyl). Unless defined otherwise, the term “alkenyl” preferably refers to C2-4 alkenyl. As used herein, the term “alkynyl” refers to a monovalent unsaturated acyclic hydrocarbon group which may be linear or branched and comprises one or more (e.g., one or two) carbon-to-carbon triple bonds and optionally one or more (e.g., one or two) carbon-to-carbon double bonds. The term “C2-5 alkynyl” denotes an alkynyl group having 2 to 5 carbon atoms. Preferred exemplary alkynyl groups are ethynyl, propynyl (e.g., propargyl), or butynyl. Unless defined otherwise, the term “alkynyl” preferably refers to C2-4 alkynyl. As used herein, the term “alkylene” refers to an alkanediyl group, i.e. a divalent saturated acyclic hydrocarbon group which may be linear or branched. A “C1-5 alkylene” denotes an alkylene group having 1 to 5 carbon atoms, and the term “C0-3 alkylene” indicates that a covalent bond (corresponding to the option “Co alkylene”) or a C1-3 alkylene is present. Preferred exemplary alkylene groups are methylene (-CH2-), ethylene (e.g., -CH2-CH2- or -CH(-CH3)-), propylene (e.g., -CH2-CH2-CH2-, -CH(-CH2-CH3)-, -CH2-4 CH(-CH3)-, or -CH(-CH3)-CH2-), or butylene (e.g., -CH2-CH2-CH2-CH2-). Unless defined otherwise, the term “alkylene” preferably refers to Cm alkylene (including, in particular, linear Cm alkylene), more preferably to methylene or ethylene, and even more preferably to methylene. As used herein, the term “alkenylene” refers to an alkenediyl group, i.e. a divalent unsaturated acyclic hydrocarbon group which may be linear or branched and comprises one or more (e.g., one or two) carbon-to-carbon double bonds while it does not comprise any carbon-to-carbon triple bond. A “C2-5 alkenylene" denotes an alkenylene group having 2 to 5 carbon atoms. Unless defined otherwise, the term “alkenylene" preferably refers to C2-4 alkenylene (including, in particular, linear C2-4 alkenylene). As used herein, the term “alkynylene” refers to an alkynediyl group, i.e. a divalent unsaturated acyclic hydrocarbon group which may be linear or branched and comprises one or more (e.g., one or two) carbon-to-carbon triple bonds and optionally one or more (e.g., one or two) carbon-to-carbon double bonds. A “C2-5 alkynylene” denotes an alkynylene group having 2 to 5 carbon atoms. Unless defined otherwise, the term “alkynylene” preferably refers to C24 alkynylene (including, in particular, linear C24 alkynylene). As used herein, the term “carbocyclyl” refers to a hydrocarbon ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings), wherein said ring group may be saturated, partially unsaturated (i.e., unsaturated but not aromatic) or aromatic. Unless defined otherwise, “carbocyclyl” preferably refers to aryl, cycloalkyl or cycloalkenyl. As used herein, the term “heterocyclyl” refers to a ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings), wherein said ring group comprises one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S, N, P and Si, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group may be saturated, partially unsaturated (i.e., unsaturated but not aromatic) or aromatic. For example, each heteroatom-containing ring comprised in said ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatomcontaining ring. Unless defined otherwise, “heterocyclyl” preferably refers to heteroaryl, heterocycloalkyl or heterocycloalkenyl. Preferably, the term “heterocyclyl” refers to a ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings), wherein said ring group comprises one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group may be saturated, partially unsaturated (i.e., unsaturated but not aromatic) or aromatic. For example, each heteroatom-containing ring comprised in said ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. Unless defined otherwise, “heterocyclyl" preferably refers to heteroaryl, heterocycloalkyl or heterocycloalkenyl. As used herein, the term “aryl” refers to an aromatic hydrocarbon ring group, including monocyclic aromatic rings as well as bridged ring and / or fused ring systems containing at least one aromatic ring (e.g., ring systems composed of two or three fused rings, wherein at least one of these fused rings is aromatic; or bridged ring systems composed of two or three rings, wherein at least one of these bridged rings is aromatic). “Aryl” may, e.g., refer to phenyl, naphthyl, dialinyl (i.e., 1,2-dihydronaphthyl), tetralinyl (i.e., 1,2,3,4-tetrahydronaphthyl), indanyl, indenyl (e.g., 1 H-indenyl), anthracenyl, phenanthrenyl, 9H-fluorenyl, or azulenyl. Unless defined otherwise, an “aryl” preferably has 6 to 14 ring atoms, more preferably 6 to 10 ring atoms, even more preferably refers to phenyl or naphthyl, and most preferably refers to phenyl. As used herein, the term “arylene” refers to an aryl group, as defined herein above, but having two points of attachment, i.e. a divalent aromatic hydrocarbon ring group, including monocyclic aromatic rings as well as bridged ring and / or fused ring systems containing at least one aromatic ring (e.g., ring systems composed of two or three fused rings, wherein at least one of these fused rings is aromatic; or bridged ring systems composed of two or three rings, wherein at least one of these bridged rings is aromatic). “Arylene” may, e.g., refer to phenylene (e.g., phen-1,2-diyl, phen-1,3-diyl, or phen-1,4-diyl), naphthylene (e.g., naphthalen-1,2-diyl, naphthalen-1,3-diyl, naphthalen-1,4-diyl, naphthalen-1,5-diyl, naphthalen-1,6-diyl, naphthalen-1,7-diyl, naphthalen-2,3-diyl, naphthalen-2,5-diyl, naphthalen-2,6-diyl, naphthalen-2,7-diyl, or naphthalen-2,8-diyl), 1,2-dihydronaphthylene, 1,2,3,4-tetrahydronaphthylene, indanylene, indenylene, anthracenylene, phenanthrenylene, 9H-fluorenylene, or azulenylene. Unless defined otherwise, an “arylene” preferably has 6 to 14 ring atoms, more preferably 6 to 10 ring atoms, even more 6 preferably refers to phenylene or naphthylene, and most preferably refers to phenylene (particularly phen-1,4-diyl). As used herein, the term “heteroaryl” refers to an aromatic ring group, including monocyclic aromatic rings as well as bridged ring and / or fused ring systems containing at least one aromatic ring (e.g., ring systems composed of two or three fused rings, wherein at least one of these fused rings is aromatic; or bridged ring systems composed of two or three rings, wherein at least one of these bridged rings is aromatic), wherein said aromatic ring group comprises one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said aromatic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heteroaryl" may, e.g., refer to thienyl (i.e., thiophenyl), benzo[b]thienyl, naphtho[2,3-b]thienyl, thianthrenyl, furyl (i.e., furanyl), benzofuranyl, isobenzofuranyl, chromanyl, chromenyl (e.g., 2H-1-benzopyranyl or 4H-1-benzopyranyl), isochromenyl (e.g., 1 H-2-benzopyranyl), chromonyl, xanthenyl, phenoxathiinyl, pyrrolyl (e.g., 1 H-pyrrolyl), imidazolyl, pyrazolyl, pyridyl (i.e., pyridinyl; e.g., 2-pyridyl, 3-pyridyl, or 4-pyridyl), pyrazinyl, pyrimidinyl, pyridazinyl, indolyl (e.g., 3H-indolyl), isoindolyl, indazolyl, indolizinyl, purinyl, quinolyl, isoquinolyl, phthalazinyl, naphthyridinyl, quinoxalinyl, cinnolinyl, pteridinyl, carbazolyl, P-carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl (e.g., [1,10]phenanthrolinyl, [1,7]phenanthrolinyl, or [4,7]phenanthrolinyl), phenazinyl, thiazolyl, isothiazolyl, phenothiazinyl, oxazolyl, isoxazolyl, oxadiazolyl (e.g., 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl (i.e., furazanyl), or 1,3,4-oxadiazolyl), thiadiazolyl (e.g., 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, or 1,3,4-thiadiazolyl), phenoxazinyl, pyrazolo[1,5-a]pyrimidinyl (e.g., pyrazolo[1,5-a]pyrimidin-3-yl), 1,2-benzoisoxazol-3-yl, benzothiazolyl, benzothiadiazolyl, benzoxazolyl, benzisoxazolyl, benzimidazolyl, benzo[b]thiophenyl (i.e., benzothienyl), triazolyl (e.g., 1H-1,2,3-triazolyl, 2H-1,2,3-triazolyl, 1H-1,2,4-triazolyl, or4H-1,2,4-triazolyl), benzotriazolyl, 1 H-tetrazolyl, 2H-tetrazolyl, triazinyl (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, or 1,3,5-triazinyl), furo[2,3-c]pyridinyl, dihydrofuropyridinyl (e.g., 2,3-dihydrofuro[2,3-c]pyridinyl or 1,3-dihydrofuro[3,4-c]pyridinyl), imidazopyridinyl (e.g., imidazo[1,2-a]pyridinyl or imidazo[3,2-a]pyridinyl), quinazolinyl, thienopyridinyl, tetrahydrothienopyridinyl (e.g., 4,5,6,7-tetrahydrothieno[3,2-c]pyridinyl), dibenzofuranyl, 1,3-benzodioxolyl, benzodioxanyl (e.g., 1,3-benzodioxanyl or 1,4-benzodioxanyl), or coumarinyl. Unless 7 defined otherwise, the term “heteroaryl” preferably refers to a 5 to 14 membered (more preferably 5 to 10 membered) monocyclic ring or fused ring system comprising one or more (e.g., one, two, three or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; even more preferably, a “heteroaryl” refers to a 5 or 6 membered monocyclic ring comprising one or more (e.g., one, two or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. As used herein, the term “heteroarylene" refers to a heteroaryl group, as defined herein above, but having two points of attachment, i.e. a divalent aromatic ring group, including monocyclic aromatic rings as well as bridged ring and / or fused ring systems containing at least one aromatic ring (e.g., ring systems composed of two or three fused rings, wherein at least one of these fused rings is aromatic; or bridged ring systems composed of two or three rings, wherein at least one of these bridged rings is aromatic), wherein said aromatic ring group comprises one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said aromatic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three, or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heteroarylene” may, e.g., refer to thienylene (i.e., thiophenylene; e.g., thien-2,3-diyl, thien-2,4-diyl, or thien-2,5-diyl), benzo[b]thienylene, naphtho[2,3-b]thienylene, thianthrenylene, furylene (i.e., furanylene; e.g., furan-2,3-diyl, furan-2,4-diyl, or furan-2,5-diyl), benzofuranylene, isobenzofuranylene, chromanylene, chromenylene, isochromenylene, chromonylene, xanthenylene, phenoxathiinylene, pyrrolylene, imidazolylene, pyrazolylene, pyridylene (i.e., pyridinylene), pyrazinylene, pyrimidinylene, pyridazinylene, indolylene, isoindolylene, indazolylene, indolizinylene, purinylene, quinolylene, isoquinolylene, phthalazinylene, naphthyridinylene, quinoxalinylene, cinnolinylene, pteridinylene, carbazolylene, p-carbolinylene, phenanthridinylene, acridinylene, perimidinylene, phenanthrolinylene, phenazinylene, thiazolylene (e.g., thiazol-2,4-diyl, thiazol-2,5-diyl, or thiazol-4,5-diyl), isothiazolylene (e.g., isothiazol-3,4-diyl, isothiazol-3,5-diyl, or isothiazol-4,5-diyl), phenothiazinylene, oxazolylene (e.g., oxazol-2,4-diyl, oxazol-2,5-diyl, or oxazol-4,5-diyl), isoxazolylene (e.g., isoxazol-3,4-diyl, isoxazol-3,5-diyl, 8 or isoxazol-4,5-diyl), oxadiazolylene (e.g., 1,2,4-oxadiazol-3,5-diyl, 1,2,5-oxadiazol-3,4-diyl, or 1,3,4-oxadiazol-2,5-diyl), thiadiazolylene (e.g., 1,2,4-thiadiazol-3,5-diyl, 1,2,5-thiadiazol-3,4-diyl, or 1,3,4-thiadiazol-2,5-diyl), phenoxazinylene, pyrazolo[1,5-a]pyrimidinylene, 1,2-benzoisoxazolylene, benzothiazolylene, benzothiadiazolylene, benzoxazolylene, benzisoxazolylene, benzimidazolylene, benzo[b]thiophenylene (i.e., benzothienylene), triazolylene (e.g., 1H-1,2,3-triazolylene, 21-1-1,2,3-triazolylene, 1H-1,2,4-triazolylene, or 4H-1,2,4-triazolylene), benzotriazolylene, 1 H-tetrazolylene, 2H-tetrazolylene, triazinylene (e.g., 1,2,3-triazinylene, 1,2,4-triazinylene, or 1,3,5-triazinylene), furo[2,3-c]pyridinylene, dihydrofuropyridinylene (e.g., 2,3-dihydrofuro[2,3-c]pyridinylene or 1,3-dihydrofuro[3,4-c]pyridinylene), imidazopyridinylene (e.g., imidazo[1,2-a]pyridinylene or imidazo[3,2-a]pyridinylene), quinazolinylene, thienopyridinylene, tetrahydrothienopyridinylene (e.g., 4,5,6,7-tetrahydroth ieno[3,2-c]pyridinylene),         dibenzofuranylene, 1,3-benzodioxolylene, benzodioxanylene (e.g., 1,3-benzodioxanylene or 1,4-benzodioxanylene), or coumarinylene. Unless defined otherwise, the term “heteroarylene” preferably refers to a divalent 5 to 14 membered (more preferably 5 to 10 membered) monocyclic ring or fused ring system comprising one or more (e.g., one, two, three or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; even more preferably, a “heteroarylene” refers to a divalent 5 or 6 membered monocyclic ring comprising one or more (e.g., one, two or three) ring heteroatoms independently selected from 0, S, and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. A “heteroarylene”, including any of the specific heteroarylene groups described herein, may be attached through two carbon ring atoms, particularly through those two carbon ring atoms that have the greatest distance from one another (in terms of the number of ring atoms separating them by the shortest possible connection) within one single ring or within the entire ring system of the corresponding heteroarylene. As used herein, the term “cycloalkyl” refers to a saturated hydrocarbon ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings). “Cycloalkyl” may, e.g., refer to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, decalinyl (i.e., decahydronaphthyl), or adamantyl. Unless defined otherwise, “cycloalkyl” preferably refers to a C3-11 cycloalkyl, and more preferably refers to a C3-7 cycloalkyl. A particularly preferred “cycloalkyl” is a monocyclic saturated hydrocarbon ring having 3 to 7 ring members (e.g., cyclopropyl or cyclohexyl). As used herein, the term “cycloalkylene” refers to a cycloalkyl group, as defined herein above, but having two points of attachment, i.e. a divalent saturated hydrocarbon ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings). “Cycloalkylene" may, e.g., refer to cyclopropylene (e.g., cyclopropan-1,1 -diyl or cyclopropan-1,2-diyl), cyclobutylene (e.g., cyclobutan-1,1-diyl, cyclobutan-1,2-diyl, or cyclobutan-1,3-diyl), cyclopentylene (e.g., cyclopentan-1,1-diyl, cyclopentan-1,2-diyl, or cyclopentan-1,3-diyl), cyclohexylene (e.g., cyclohexan-1,1-diyl, cyclohexan-1,2-diyl, cyclohexan-1,3-diyl, or cyclohexan-1,4-diyl), cycloheptylene, decalinylene (i.e., decahydronaphthylene), or adamantylene. Unless defined otherwise, “cycloalkylene” preferably refers to a C3-11 cycloalkylene, and more preferably refers to a C3-7 cycloalkylene. A particularly preferred “cycloalkylene” is a divalent monocyclic saturated hydrocarbon ring having 3 to 7 ring members (e.g., cyclopropylene or cyclohexylene). As used herein, the term “heterocycloalkyl” refers to a saturated ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S, N, P and Si, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said saturated ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkyl” may, e.g., refer to aziridinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, azepanyl, diazepanyl (e.g., 1,4-diazepanyl), oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl (e.g., morpholin-4-yl), thiomorpholinyl (e.g., thiomorpholin-4-yl), oxazepanyl, oxiranyl, oxetanyl, tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydropyranyl, 1,4-dioxanyl, oxepanyl, thiiranyl, thietanyl, tetrahydrothiophenyl (i.e., thiolanyl), 1,3-dithiolanyl, thianyl, 1,1 -dioxothianyl, thiepanyl, decahydroquinolinyl, decahydroisoquinolinyl, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl. Unless defined otherwise, “heterocycloalkyl” preferably refers to a 3 to 11 membered saturated ring group, which is a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms 10 independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; more preferably, “heterocycloalkyl” refers to a 5 to 7 membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. Preferably, the term “heterocycloalkyl” refers to a saturated ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said saturated ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkyl” may, e.g., refer to aziridinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, azepanyl, diazepanyl (e.g., 1,4-diazepanyl), oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, morpholinyl (e.g., morpholin-4-yl), thiomorpholinyl (e.g., thiomorpholin-4-yl), oxazepanyl, oxiranyl, oxetanyl, tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydropyranyl, 1,4-dioxanyl, oxepanyl, thiiranyl, thietanyl, tetrahydrothiophenyl (i.e., thiolanyl), 1,3-dithiolanyl, thianyl, 1,1-dioxothianyl, thiepanyl, decahydroquinolinyl, decahydroisoquinolinyl, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl. Unless defined otherwise, “heterocycloalkyl” preferably refers to a 3 to 11 membered saturated ring group, which is a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; more preferably, “heterocycloalkyl” refers to a 5 to 7 membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. As used herein, the term “heterocycloalkylene” refers to a heterocycloalkyl group, as defined herein above, but having two points of attachment, i.e. a divalent saturated ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S, N, P and Si, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said saturated ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkylene” may, e.g., refer to aziridinylene, azetidinylene, pyrrolidinylene, imidazolidinylene, pyrazolidinylene, piperidinylene, piperazinylene, azepanylene, diazepanylene (e.g., 1,4-diazepanylene), oxazolidinylene, isoxazolidinylene, thiazolidinylene, isothiazolidinylene, morpholinylene, thiomorpholinylene, oxazepanylene, oxiranylene, oxetanylene, tetrahydrofuranylene, 1,3-dioxolanylene, tetrahydropyranylene, 1,4-dioxanylene, oxepanylene, thiiranylene, thietanylene, tetrahydrothiophenylene (i.e., thiolanylene), 1,3-dithiolanylene, thianylene, 1,1-dioxothianylene, thiepanylene, decahydroquinolinylene, decahydroisoquinolinylene, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylene. Unless defined otherwise, “heterocycloalkylene” preferably refers to a divalent 3 to 11 membered saturated ring group, which is a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; more preferably, “heterocycloalkylene” refers to a divalent 5 to 7 membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. Preferably, the term “heterocycloalkylene” refers to a heterocycloalkyl group, as defined herein above, but having two points of attachment, i.e. a divalent saturated ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or 12 three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, and further wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group). For example, each heteroatom-containing ring comprised in said saturated ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkylene" may, e.g., refer to aziridinylene, azetidinylene, pyrrolidinylene, imidazolidinylene, pyrazolidinylene, piperidinylene, piperazinylene, azepanylene, diazepanylene (e.g., 1,4-diazepanylene), oxazolidinylene, isoxazolidinylene, thiazolidinylene, isothiazolidinylene, morpholinylene, thiomorpholinylene, oxazepanylene, oxiranylene, oxetanylene, tetrahydrofuranylene, 1,3-dioxolanylene, tetrahydropyranylene, 1,4-dioxanylene, oxepanylene, thiiranylene, thietanylene, tetrahydrothiophenylene (i.e., thiolanylene), 1,3-dithiolanylene, thianylene, 1,1-dioxothianylene, thiepanylene, decahydroquinolinylene, decahydroisoquinolinylene, or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-ylene. Unless defined otherwise, “heterocycloalkylene” preferably refers to a divalent 3 to 11 membered saturated ring group, which is a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized; more preferably, “heterocycloalkylene” refers to a divalent 5 to 7 membered saturated monocyclic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, and wherein one or more carbon ring atoms are optionally oxidized. As used herein, the term “A / -heterocycloalkyl” refers to the heterocycloalkyl groups as defined hereinabove wherein said heterocycloalkyl includes at least one nitrogen atom which serves as an attachment point of said heterocycloalkyl. As used herein, the term “cycloalkenyl” refers to an unsaturated alicyclic (non-aromatic) hydrocarbon ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said hydrocarbon ring group comprises one or more (e.g., one or 13 two) carbon-to-carbon double bonds and does not comprise any carbon-to-carbon triple bond. “Cycloalkenyl” may, e.g., refer to cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl, cycloheptenyl, or cycloheptadienyl. Unless defined otherwise, “cycloalkenyl” preferably refers to a C3-11 cycloalkenyl, and more preferably refers to a C3-7 cycloalkenyl. A particularly preferred “cycloalkenyl" is a monocyclic unsaturated alicyclic hydrocarbon ring having 3 to 7 ring members and containing one or more (e.g., one or two; preferably one) carbon-to-carbon double bonds. As used herein, the term “cycloalkenylene” refers to a cycloalkenyl group, as defined hereinabove, but having two points of attachment, i.e. a divalent unsaturated alicyclic (non-aromatic) hydrocarbon ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said hydrocarbon ring group comprises one or more (e.g., one or two) carbon-to-carbon double bonds and does not comprise any carbon-to-carbon triple bond. As used herein, the term “heterocycloalkenyl” refers to an unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S, N, P and Si, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. For example, each heteroatom-containing ring comprised in said unsaturated alicyclic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkenyl” may, e.g., refer to imidazolinyl (e.g., 2-imidazolinyl (i.e., 4,5-dihydro-1H-imidazolyl), 3-imidazolinyl, or 4-imidazolinyl), tetrahydropyridinyl (e.g., 1,2,3,6-tetrahydropyridinyl), dihydropyridinyl (e.g., 1,2-dihydropyridinyl or 2,3-dihydropyridinyl), pyranyl (e.g., 2H-pyranyl or 4H-pyranyl), thiopyranyl (e.g., 2H-thiopyranyl or 4H-thiopyranyl), dihydropyranyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrazinyl, dihydroisoindolyl, octahydroquinolinyl (e.g., 1,2,3,4,4a,5,6,7-octahydroquinolinyl), or octahydroisoquinolinyl (e.g., 1,2,3,4,5,6,7,8-octahydroisoquinolinyl). Unless defined otherwise, “heterocycloalkenyl” preferably refers to a 3 to 11 membered unsaturated alicyclic ring 14 group, which is a monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized, and wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms; more preferably, “heterocycloalkenyl" refers to a 5 to 7 membered monocyclic unsaturated non-aromatic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized, and wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. Preferably, the term “heterocycloalkenyl" refers to an unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. For example, each heteroatom-containing ring comprised in said unsaturated alicyclic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. “Heterocycloalkenyl” may, e.g., refer to imidazolinyl (e.g., 2-imidazolinyl (i.e., 4,5-dihydro-1H-imidazolyl), 3-imidazolinyl, or 4-imidazolinyl), tetrahydropyridinyl (e.g., 1,2,3,6-tetrahydropyridinyl), dihydropyridinyl (e.g., 1,2-dihydropyridinyl or 2,3-dihydropyridinyl), pyranyl (e.g., 2H-pyranyl or 4H-pyranyl), thiopyranyl (e.g., 2H-thiopyranyl or 4H-thiopyranyl), dihydropyranyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrazinyl, dihydroisoindolyl, octahydroquinolinyl (e.g., 1,2,3,4,4a,5,6,7-octahydroquinolinyl), or octahydroisoquinolinyl (e.g., 1,2,3,4,5,6,7,8-octahydroisoquinolinyl). Unless defined otherwise, “heterocycloalkenyl” preferably refers to a 3 to 11 membered unsaturated alicyclic ring group, which is a 15 monocyclic ring or a fused ring system (e.g., a fused ring system composed of two fused rings), wherein said ring group contains one or more (e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized, and wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms; more preferably, “heterocycloalkenyl” refers to a 5 to 7 membered monocyclic unsaturated non-aromatic ring group containing one or more (e.g., one, two, or three) ring heteroatoms independently selected from 0, S and N, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) are optionally oxidized, wherein one or more carbon ring atoms are optionally oxidized, and wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. As used herein, the term “heterocycloalkenylene” refers to a heterocycloalkenyl group, as defined hereinabove, as defined hereinabove, but having two points of attachment, i.e. a divalent unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S, N, P and Si and the remaining ring atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) and / or one or more P ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. For example, each heteroatom-containing ring comprised in said unsaturated alicyclic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. Preferably, the term “heterocycloalkenylene” refers to a heterocycloalkenyl group, as defined hereinabove, as defined hereinabove, but having two points of attachment, i.e. a divalent unsaturated alicyclic (non-aromatic) ring group, including monocyclic rings as well as bridged ring, spiro ring and / or fused ring systems (which may be composed, e.g., of two or three rings; such as, e.g., a fused ring system composed of two or three fused rings), wherein said ring group contains one or more (such as, e.g., one, two, three, or four) ring heteroatoms independently selected from 0, S and N, and the remaining ring 16 atoms are carbon atoms, wherein one or more S ring atoms (if present) and / or one or more N ring atoms (if present) may optionally be oxidized, wherein one or more carbon ring atoms may optionally be oxidized (i.e., to form an oxo group), and further wherein said ring group comprises at least one double bond between adjacent ring atoms and does not comprise any triple bond between adjacent ring atoms. For example, each heteroatom-containing ring comprised in said unsaturated alicyclic ring group may contain one or two 0 atoms and / or one or two S atoms (which may optionally be oxidized) and / or one, two, three or four N atoms (which may optionally be oxidized), provided that the total number of heteroatoms in the corresponding heteroatom-containing ring is 1 to 4 and that there is at least one carbon ring atom (which may optionally be oxidized) in the corresponding heteroatom-containing ring. As used herein, the term "halogen” refers to fluoro (-F), chloro (-CI), bromo (-Br), or iodo (-I). As it is to be understood for the skilled person, the terms “halogen” and “halo” may be used interchangeably. As used herein, the term “haloalkyl” refers to an alkyl group substituted with one or more (preferably 1 to 6, more preferably 1 to 3) halogen atoms which are selected independently from fluoro, chloro, bromo and iodo, and are preferably all fluoro atoms. It will be understood that the maximum number of halogen atoms is limited by the number of available attachment sites and, thus, depends on the number of carbon atoms comprised in the alkyl moiety of the haloalkyl group. “Haloalkyl” may, e.g., refer to -CF3, -CHF2, -CH2F, -CF2-CH3, -CH2-CF3, -CH2-CHF2i -CH2-CF2-CH3i -CH2-CF2-CF3i or -CH(CF3)2. A particularly preferred “haloalkyl” group is -CF3. The terms “bond” and “covalent bond” are used herein synonymously, unless explicitly indicated otherwise or contradicted by context. As used herein, the terms “optional”, “optionally” and “may” denote that the indicated feature may be present but can also be absent. Whenever the term “optional”, “optionally” or “may” is used, the present invention specifically relates to both possibilities, i.e., that the corresponding feature is present or, alternatively, that the corresponding feature is absent. For example, the expression “X is optionally substituted with Y” (or “X may be substituted with Y”) means that X is either substituted with Y or is unsubstituted. Likewise, if a component of a composition is indicated to be “optional”, the invention specifically relates to both possibilities, i.e., that the corresponding component is present (contained in the composition) or that the corresponding component is absent from the composition. Various groups are referred to as being “optionally substituted” in this specification. Generally, these groups may carry one or more substituents, such as, e.g., one, two, three or four substituents. It will be understood that the maximum number of substituents is limited by the number of attachment sites available on the substituted moiety. Unless defined otherwise, the “optionally substituted” groups referred to in this specification carry preferably not more than two substituents and may, in particular, carry only 17 one substituent. Moreover, unless defined otherwise, it is preferred that the optional substituents are absent, i.e. that the corresponding groups are unsubstituted. A skilled person will appreciate that the substituent groups comprised in the compounds of the present invention may be attached to the remainder of the respective compound via a number of different positions of the corresponding specific substituent group. Unless defined otherwise, the preferred attachment positions for the various specific substituent groups are as illustrated in the examples. As used herein, unless explicitly indicated otherwise or contradicted by context, the terms "a”, "an” and “the” are used interchangeably with “one or more” and “at least one". Thus, for example, a composition comprising “a" compound of formula (I) can be interpreted as referring to a composition comprising “one or more” compounds of formula (I). It is to be understood that wherever numerical ranges are provided / disclosed herein, all values and subranges encompassed by the respective numerical range are meant to be encompassed within the scope of the invention. Accordingly, the present invention specifically and individually relates to each value that falls within a numerical range disclosed herein, as well as each subrange encompassed by a numerical range disclosed herein. As used herein, the term “about” preferably refers to ±10% of the indicated numerical value, more preferably to ±5% of the indicated numerical value, and in particular to the exact numerical value indicated. If the term “about” is used in connection with the endpoints of a range, it preferably refers to the range from the lower endpoint -10% of its indicated numerical value to the upper endpoint +10% of its indicated numerical value, more preferably to the range from of the lower endpoint -5% to the upper endpoint +5%, and even more preferably to the range defined by the exact numerical values of the lower endpoint and the upper endpoint. As used herein, the term “comprising” (or “comprise”, “comprises”, “contain”, “contains”, or “containing”), unless explicitly indicated otherwise or contradicted by context, has the meaning of “containing, inter alia”, i.e., “containing, among further optional elements,...”. In addition thereto, this term also includes the narrower meanings of “consisting essentially of’ and “consisting of’. For example, the term “A comprising B and C” has the meaning of “A containing, inter alia, B and C”, wherein A may contain further optional elements (e.g., “A containing B, C and D” would also be encompassed), but this term also includes the meaning of “A consisting essentially of B and C” and the meaning of “A consisting of B and C” (i.e., no other components than B and C are comprised in A). Detailed description of the invention The invention is described in detail in the following. It is to be understood that the present invention specifically relates to each and every combination of features and embodiments described herein, including any combination of general and / or preferred features / embodiments. In a first embodiment, the present invention relates to a compound of formula (I): R4 (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl, (Ci-2)haloalkyl, -(C1-2 alkylene)-OH and -(C1-2 alkylene)-O-(Ci-2 alkyl), preferably from the group consisting of chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl, (C1-2)haloalkyl, -(C1-2 alkylene)-OH and -(C1-2 alkylene)-O-(Ci-2 alkyl). Preferably, Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (C1-2)haloalkyl, preferably from the group consisting of chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (C1-2)alkyl, and (Ci-2)haloalkyl. Preferably, (Ci-2)alkyl as discussed herein is methyl. Preferably, (Ci-2)haloalkyl as discussed herein is fluoromethyl. Thus, preferably Ri is selected from the group consisting of cyano, methyl and fluoromethyl. More preferably, Ri is cyano. However, in an alternative preferred embodiment, Ri is methyl, in a particularly preferred alternative embodiment wherein Ri is methyl, Ri is CD3. In again an alternative preferred embodiment, Ri is fluoromethyl. R2 and R3 are independently each (Ci-2)alkyl or (Ci-2)haloalkyl, preferably methyl, or R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Preferably, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. W is selected from -NHS(O)y-, -S(O)yNH-, -NHS(O)(NH)-, -NHS(O)(NCH3)-, -S(O)(NH)-NH-, -S(O)(NCH3)-NH-, wherein y is 1 or 2. Preferably, y is 2. Thus, in a preferred embodiment, W is selected from -NHS(O)2-, -S(O)2NH-, -NHS(O)(NH)-, and -S(O)(NH)-NH-. More preferably, W is selected from -NHS(O)2-, and -S(O)2NH-, even more preferably W is -NHS(O)2-. Preferably as understood herein, the left side of W as defined herein is attached to the carbon atom that carries Ri, R2 and R3, and the right side of W as defined herein is attached to the ring system shown in formula (I). In one preferred embodiment, W is -NHS(O)2- or -NHS(O)(NCH3)-. In one preferred embodiment, W is -NHS(O)(NCH3)-. Xi and X3 are independently selected from the group consisting of N, CH, C(Ci-2 alkyl), CCI and CF, preferably independently selected from the group consisting of N, CH and CF. Preferably, Xi is CF or CH and X3 is CH, more preferably Xi and X3 are each CH. However, in an alternative preferred embodiment, Xi is CF and X3 is CH. X2 is N or C-Yc2-Rc2, preferably X2 is C-Yc2-Rc2. Yc2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, C2-5 alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene and heterocycloalkenylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, SH, S(Cis alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(C1-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-s alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-s alkyl)-, CO-, S-, -SO-, and SO2-, and further wherein said cycloalkylene, said cycloalkenylene, said heterocycloalkylene and said heterocycloalkenylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-C0-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CON H2, N(Ci-s alkyl)CONH-(Ci-s alkyl), and N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5alkylene)OH, -(C1-5alkylene)O(Ci-5alkyl), -(C1-5alkylene)-O(Ci-s haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)(A / -heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)CO-(W-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(C1-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-s alkyl), and -(C1-5 alkylene)N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), 20 preferably selected from halogen, CN, OH, C1-5 alkyl, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-5 alkyl)(Ci-5 alkyl). Preferably, Yc2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, C2-5 alkynylene, cycloalkylene and heterocycloalkylene wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci^ alkyl), N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and N(Ci-5 alkyl)CON(C 1-5 alkyl)(C 1-5 alkyl), preferably selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-s alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-s alkyl)-, CO-, S-, -SO-, and SO2-, and further wherein said cycloalkylene and said heterocycloalkylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci^ alkyl), -NH(Ci^ haloalkyl), N(Ci-s alkyl)(Ci^ alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-s alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-s alkyl)CONH-(Ci-5 alkyl), and N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Cis alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-s alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-( / V-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-s alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-s alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-s alkyl), and N(Ci-5 alkyl)(Ci-5 alkyl). More preferably, YC2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, and C2-5 alkynylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), C1-5 haloalkyl, SH, S(Ci5 21 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(C1-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-s alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-5 alkyl)-, CO-, S-, -SO-, and SO2-. More preferably, Yc2 is selected from a covalent bond, -(C1-3 alkylene)-, -CO-(Ci-3 alkylene)-, (C1-3 alkylene)-CO-, -CONH-(Ci-3 alkylene)-, -(C1-3 alkylene)-CONH-, -NHCO-(Ci-3 alkylene)-, -(C1-3 alkylene)-NHCO-, -NH-(Ci-3 alkylene), -(C1-3 alkylene)-NH-, -N(Ci-5 alkyl)-, -0-(Ci-3 alkylene)-, -(C1-3 alkylene)-O-, SO2-(Ci-3 alkylene)-, -(C1-3 alkylene)S02-, -CONH-, -NHCO-, -NH-, -0-, -CO- and SO2-. C1-3 alkylene is herein preferably a -CH2-group. Rc2 is selected from hydrogen, halo, -OH, -NH2, -SH, -CN, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl. Preferably, Rc2 is selected from hydrogen, halo, -OH, -NH2, -SH, -CN, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. More preferably, Rc2 is selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, Rc2 is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, Rc2 is selected from heterocycloalkyl, aryl, and heteroaryl. Said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N (C1-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -C0(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-s alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)C0NH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), and -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -0(Ci-5 alkyl)-, -0(Ci-5 haloalkyl)-, C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -C0(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -22 0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci^ alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(Ci-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(Ci^ alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-s alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Ci5 alkyl), S(O)(Cis alkyl), S(O)2(Ci5 alkyl), S(O)(NH)(Ci5 alkyl), S(O)(N(Cis alkyl))(Ci5 alkyl), -N=S(O)(Cis alkyl)(Cis alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), COO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-s alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-s alkyl)CONH-(Ci-5 alkyl), N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-s alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), NHCOO(Ci-5 alkyl), N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Cis alkyl), -P(O)(O(Ci-5 alkyl))(O(Cis alkyl)), -P(O)(O(Ci-5 23 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Cis alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)S(0)(Ci5 alkyl), -(C1-5 alkylene)S(O)2(Ci5 alkyl), -(C1-5 alkylene)S(O)(NH)(Ci5 alkyl), -(C1-5 alkylene)S(0)(N(Ci5 alkyl))(Ci5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci5 alkyl), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(O(Ci5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci^ alkyl), -(C1-5 alkylene)CO-(W-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(Ci^ alkylene)-OCONH2, -(Ci^ alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(Ci-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-s alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-s alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-24 5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Thus, preferably, -Yc2-Rc2 is selected from -O-Ci-i2 alkyl, -NH-Ci-i2 alkyl, -N(Ci-5 alkyl)-Ci-i2 alkyl, -O-C2-i2 alkenyl, -NH-C2-i2 alkenyl, -N(Ci-5 alkyl)-C2-i2 alkenyl, -O-C2-i2 alkynyl, -NH-C2-i2 alkynyl, -N(Ci-5 alkyl)-C2-i2 alkynyl, (C0-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-CO-cycloalkyl, -CONH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-CONH-cycloalkyl, -NHCO-(Co-3 alkylene)cycloalkyl, (Co-3 alkylene)-NHCO-cycloalkyl, -NH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-NH-cycloalkyl, -0-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -S02-cycloalkyl, (C0-3 alkylene)-cycloalkenyl, -CO-(Co-3 alkylene)cycloalkenyl, (C0-3 alkylene)-CO-cycloalkenyl, -CONH-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-CONH-cycloalkenyl, -NHCO-(Co-3 alkylene)cycloalkenyl, (C0-3 alkylene)-NHCO-cycloalkenyl, -NH-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-NH-cycloalkenyl, -0-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-O-cycloalkenyl, -S02-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, -SO2-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, -(C0-3 alkylene)-O-heterocycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CO-heterocycloalkenyl, -CONH-(Co-3 25 alkylene)heterocycloalkenyl, alkylene)heterocycloalkenyl, alkylene)heterocycloalkenyl, -(Co-3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(Co-3 -(Co-3 alkylene)-NHCO-heterocycloalkenyl, -NH-(Co-3 -(Co-3 alkylene)-NH-heterocycloalkenyl, -0-(Co-3 alkylene) heterocycloalkenyl, -(C0-3 alkylene)-O-heterocycloalkenyl, -S02-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, (C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, (C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -O-C1-12 alkyl, -NH-C1-12 alkyl, -N(Ci-5 alkyl)-Ci-12 alkyl, -O-C2-12 alkenyl, -NH-C2-12 alkenyl, -N(Ci-5 alkyl)-C2-i2 alkenyl, -O-C2-12 alkynyl, -NH-C2-12 alkynyl, -N(Ci-5 alkyl)-C2-i2 alkynyl, (C0-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-CO-cycloalkyl, -CONH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-CONH-cycloalkyl, -NHCO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-NHCO-cycloalkyl, -NH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-NH-cycloalkyl, -0-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)cycloalkyl, -(Co-3 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(C0-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, (C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -COaryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -26 CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, (C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-S02-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(A / -heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), and -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl) and wherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-s alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-s alkyl)(Ci-5 alkyl), -C0-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-s alkyl), -OCON(Ci-s alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-s alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-s alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 T1 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-s alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5  alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 28 alkyl)C00-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci^ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci^ alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci^ haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably, -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-29 heterocycloalkyl, -NH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, (C0-3 alkylene)-O-cycloalkyl, (C0-3 alkylene)-O-heterocycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CO-heterocycloalkenyl, -CONH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NHCO-heterocycloalkenyl, -NH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NH-heterocycloalkenyl, -0-(Co-3 alkylene) heterocycloalkenyl, (C0-3 alkylene)-O-heterocycloalkenyl, -S02-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, (C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl,-CONH-heterocycloalkyl, -NHCO-heterocycloalkyl,-NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(C0-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 30 alkylene)heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-s alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(Ci-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-s alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -31 C0(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-s alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(Ci^ alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(Ci^ alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 32 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(0-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(O-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(Ci-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(0-5 haloalkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(O-5 alkyl), -NH(O-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -C0(O-s alkyl), -CONH2, -C0NH(O-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably, -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(Co-3alkylene)-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C0-3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -0-aryl, -CO-aryl, -SO2-aryl, -(C0-3 alkylene)heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C0-3 alkylene)heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-s alkyl), -S(O)(N(Ci-s alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -33 C0(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci^ alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(A / -heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci^ haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-s alkyl)(Ci-s alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 34 alkylene)-S(0)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-s alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 35 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(Ci-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci^ alkyl). Even more preferably, -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)aryl, and -(C0-3 alkylene)heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)aryl, and -(C0-3 alkylene)heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-s haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-s alkyl), -(C1-5 alkylene)-NH(Ci-s haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 36 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-0C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHC00(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C00-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-s alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci^ alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci^ alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-s alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci^ haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 37 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHC0N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)C0NH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(0)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(Ci^ alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Even more preferably, -Yc2-Rc2 is selected from heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, more preferably heterocycloalkyl, aryl, and heteroaryl, more preferably heterocycloalkyl and heteroaryl, even more preferably, heterocycloalkyl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -38 CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(Ci^ alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-s alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(A / -heterocycloalkyl), -NHCO-(Ci-s alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), -N(Ci-s alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-s alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-s alkyl))(Ci-5 39 alkyl), -(C1-5 alkylene)-P(0)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(N-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5  alkyl),   -(C1-5 alkylene)-NHCONH2,   -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci^ alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci^ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-s alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 40 alkyl), -(Ci-5 alkylene)-0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 haloalkyl), -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). In one embodiment, -Yc2-Rc2 is heterocycloalkenyl, wherein said heterocycloalkenyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci^ alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-41 5 alkyl), -(Ci-5 alkylene)-0C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHC00(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C00-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-s alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(N-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci^ alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci^ alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2,  -(C1-5 alkylene)-CONH(Ci-5 alkyl),  -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl),   -(C1-5 alkylene)-NHCONH2,   -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-s alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-s alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -42 P(0)(0(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(0)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably, if -Yc2-Rc2 is aryl, -Yc2-Rc2 is phenyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-s alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 43 alkyl)C00-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(Ci^ alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-s alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-s alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 44 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHC0-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C00-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, Ci-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-s alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-s alkyl)(Ci-5 alkyl), -(Ci-5 alkylene)-N(Ci-5 haloalkyl)(Ci-s alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 45 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably, if -Yc2-Rc2 is heteroaryl, -Yc2-Rc2 is imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or indazolyl, wherein heteroaryl may be optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci^ alkyl), -NH(Ci^ haloalkyl), -N(Ci-5 alkyl)(Ci-s alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)),-(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-s alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-s alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from 46 halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably, if -Yc2-Rc2 is heterocycloalkyl, -Yc2-Rc2 is morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6- dihydropyridinyl, or piperazinyl, wherein heterocycloalkyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci^ alkyl), -C0-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci^ alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-s alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-s alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -N=S(O)(Ci-5 alkyl)(Ci-s alkyl), -S(Ci-5 47 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5  alkyl), -(C1-5 alkylene)-CONH2, -(C1-5  alkylene)-CONH(Ci-5 alkyl),  -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(A / -heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl),   -(C1-5 alkylene)-NHCONH2,   -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci^ haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-s alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-s alkyl), -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(Ci-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 48 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(0-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(0-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(O-5 alkyl), -NH(O-5 haloalkyl), -N(O-5 alkyl)(Ci-5 alkyl), -N(O-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(Ci-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from, halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -00(0-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -C0N(Ci-5 alkyl)(O-5 alkyl). More preferably, -Yc2-Rc2 is piperazinyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(0-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(0)(Ci-5 alkyl), -S(0)2(O-5 alkyl), -S(0)(NH)(O-5 alkyl), -S(0)(N(Ci-5 alkyl))(O-5 alkyl), -N=S(0)(O-5 alkyl)(O-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(O-5 alkyl), -NH(Ci-5 haloalkyl), -N(O-s alkyl)(Ci-s alkyl), -N(O-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -C0(O-5 alkyl), -C0(Ci-5 haloalkyl), -CO-cycloalkyl, -C00(Ci-5 alkyl), -C00(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -C0NH(O-s alkyl), -C0N(O-s alkyl)(Ci-s alkyl), -CO-(W-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(O-5 alkyl)-C0-(Ci-5 alkyl), -NHCONH2, -NHC0NH-(O-s alkyl), -NHC0N(O-5 alkyl)(O-5 alkyl), -N(O-5 alkyl)CONH2, -N(O-s alkyl)C0NH-(O-s alkyl), -N(O-s alkyl)C0N(O-5 alkyl)(O-5 alkyl), -OCONH2, -0C0NH-(Ci-5 alkyl), -0C0N(O-s alkyl)(O-5 alkyl), -NHC00(O-5 alkyl), -N(O-5 alkyl)C00-(Ci-5 alkyl), -P(0)(O-5 alkyl)(O-5 alkyl), -P(0)(0(0-5 alkyl))(0(O-5 alkyl)), -P(0)(0(0-5 alkyl))(O-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(O-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(O-5 alkyl), -(C1-5 alkylene)-S(O-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(0)2(O-5 alkyl), -(C1-5 alkylene)-S(0)(NH)(O-s alkyl), -(C1-5 alkylene)-S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(0)(O-5 alkyl)(O-5 alkyl), -(C1-5 49 alkylene)-P(0)(0(Ci-5 alkyl))(0(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(N-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci^ alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci^ alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-s alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-s alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 50 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C00-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(A / -heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci^ alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci^ haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl). Even more preferably, -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) optionally substituted (preferably N-substituted) with -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 51 alkyl), and -C0N(Ci-5 alkyl)(Ci-5 alkyl). Most preferably, -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. Preferably, if -Yc2-Rc2 is heterocycloalkenyl, -Yc2-Rc2 is oxacyclohexenyl or azacyclohexenyl, wherein heterocycloalkenyl is optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Cis alkyl), S(O)(Cis alkyl), S(O)2(Ci5 alkyl), S(O)(NH)(Cis alkyl), S(O)(N(Ci5 alkyl))(Ci5 alkyl), -N=S(O)(Cis alkyl)(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), NHCOO(Ci-5 alkyl), N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)S(O)(Ci5 alkyl), -(C1-5 alkylene)S(O)2(Ci5 alkyl), -(C1-5 alkylene)S(O)(NH)(Ci5 alkyl), -(C1-5 alkylene)S(O)(N(Ci5 alkyl))(Ci5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Cis alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-s haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)CO-( / V-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(C1-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-s alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Ci5 alkyl), S(O)(Ci5 alkyl), S(O)2(Ci5 alkyl), S(O)(NH)(Ci5 alkyl), S(O)(N(Cis alkyl))(Cis alkyl), -N=S(O)(Cis alkyl)(Cis alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), COO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 52 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), NHCOO(Ci-5 alkyl), N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)S(0)(Ci5 alkyl), -(C1-5 alkylene)S(O)2(Ci5 alkyl), -(C1-5 alkylene)S(0)(NH)(Ci5 alkyl), -(C1-5 alkylene)S(O)(N(Ci5 alkyl))(Cis alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)(W-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(Ci^ alkylene)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-( / V-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-s alkyl), -N=S(O)(Ci-5 alkyl)(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-s alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-s alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(Ci-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-s haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-53 heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from, halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci^ haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably, -Yc2-Rc2 is azacyclohexenyl, optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), SH, S(Ci5 alkyl), S(O)(C15 alkyl), S(O)2(Ci5 alkyl), S(O)(NH)(Cis alkyl), S(O)(N(Ci5 alkyl))(Ci5 alkyl), -N=S(O)(Cis alkyl)(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-s alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), NHCOO(Ci-5 alkyl), N(Ci-5 alkyl)COO-(Ci-s alkyl), -P(O)(Ci-5 alkyl)(Cis alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)S(O)(Ci5 alkyl), -(C1-5 alkylene)S(O)2(Ci5 alkyl), -(C1-5 alkylene)S(O)(NH)(Ci5 alkyl), -(C1-5 alkylene)S(O)(N(Cis alkyl))(Cis alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Cis alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-s haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 54 alkylene)-C0(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)C0NH2, -(C1-5 alkylene)C0NH(Ci-5 alkyl), -(C1-5 alkylene)C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-( / V-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-C0-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)COO-(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Cis alkyl), S(O)(Cis alkyl), S(O)2(Ci5 alkyl), S(O)(NH)(Ci5 alkyl), S(O)(N(Cis alkyl))(Ci5 alkyl), -N=S(O)(Cis alkyl)(Cis alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), COO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-s alkyl)CONH-(Ci-5 alkyl), N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), NHCOO(Ci-5 alkyl), N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)S(O)(Ci5 alkyl), -(C1-5 alkylene)S(O)2(Ci5 alkyl), -(C1-5 alkylene)S(O)(NH)(Ci5 alkyl), -(C1-5 alkylene)S(O)(N(Ci5 alkyl))(Cis alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Cis alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-(W-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-s alkyl)CONH-(Ci-s alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-s alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 55 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci^ alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5alkyl))(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5alkylene)-O(Ci-5 alkyl), -(Ci-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(Ci^ alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(Ci^ alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N (C1-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl). Even more preferably, -Yc2-Rc2 is azacyclohexenyl substituted (preferably N-substituted) with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. Preferably, azacyclohexenyl as referred to herein is 1,2,3,6-tetrahydropyridinyl. In another preferred embodiment, if-Yc2-Rc2 is heterocycloalkyl, -Yc2-Rc2 is 2-oxaspiro[3.5]non-6-en-7-yl, 2-oxaspiro[3.5]non-7-yl, 2-oxa-8-azaspiro[4.5]dec-8-yl, 9-oxa-3-azaspiro[5.5]undec-3-yl, 2-oxa-6-azaspiro[3.4]oct-6-yl, 1 -oxa-7-azaspiro[3.5]non-7-yl, 1 -oxa-8-azaspiro[4.5]dec-8-yl, 6-oxa-2-56 azaspiro[3.3]hept-2-yl, 2,8-diazaspiro[4.5]dec-8-yl, 7-oxa-3-azabicyclo[3.3.0]oct-3-yl, 8-oxa-3-azabicyclo[4.3.0]non-3-yl, 2-oxa-6-azaspiro[3.5]non-6-yl, 7-oxo-3,6,8-triazabicyclo[4.3.0]non-3-yl, 3-pyrrolino[3,4-c]pyrazol-2-yl, 3,6- diazabicyclo[3.1.1 ]hept-3-yl, or 2,7-diazaspiro[3.5]non-7-yl. In one specific embodiment, -Yc2-Rc2 is selected from: In one specific embodiment, -Yc2-Rc2 is selected from: and X4 is N or C-Rc4. Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), -N(Ci-6 alkyl)(Ci-6 alkyl), -CO(Ci-6 alkyl), C1-6 haloalkyl, -O(Ci-6 haloalkyl), -S(Ci-6 haloalkyl), -NH(Ci-6 haloalkyl), -N(Ci-6 haloalkyl, -CO(Ci-6 haloalkyl), -(C0-3 alkylene)cycloalkyl, -0-(Co-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)cycloalkenyl, -0-(Co-3 alkylene)-cycloalkenyl, -CO-(Co-3 alkylene)-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -0-(Co-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -0-(Co-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)-aryl, -0-(Co-3 alkylene)-aryl, -CO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-heteroaryl, -0-(Co-3 alkylene)-heteroaryl and -CO-(Co-3 alkylene)-heteroaryl, preferably selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), -N(Ci-6 alkyl)(Ci-6 alkyl), -CO(Ci-6 alkyl), C1-6 haloalkyl, -O(Ci-6 haloalkyl), -S(Ci-6 haloalkyl), 57 -NH(Ci-6 haloalkyl), -N(Ci-6 haloalkyl)2, -C0(Ci-6 haloalkyl), -(C0-3 alkylene)cycloalkyl, -0-(Co-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -0-(Co-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl, -0-(Co-3 alkylene)-aryl, -CO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-heteroaryl, -0-(Co-3 alkylene)-heteroaryl and -CO-(Co-3 alkylene)-heteroaryl. Said alkyl or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably said alkyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-s alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 58 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-C0(Ci-5 alkyl), -(C1-5 alkylene)-C0NH2, -(C1-5 alkylene)-C0NH(Ci-5 alkyl), -(C1-5 alkylene)-C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N (Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), C1-6 haloalkyl, -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)-aryl and -(C0-3 alkylene)-heteroaryl, preferably selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -N H(Ci-6 alkyl), C1-6 haloalkyl, -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl and -(C0-3 alkylene)-heteroaryl. Said alkyl or alkynyl (preferably said alkyl) is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -O(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl). Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-s alkyl), -CON(Ci-s alkyl)(Ci-s alkyl), -C0-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 59 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(C1-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 haloalkyl), -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci^ alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Further preferably, Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O-C1-6 alkyl, -S-C1-6 alkyl, -NH-C1-6 alkyl, and C1-6 haloalkyl, more preferably Rc4 is selected from hydrogen, halo, Ci-2 alkyl, and C2-3 alkynyl, even more preferably Rc4 is selected from hydrogen, halo, and Ci-2 alkyl, even more preferably Rc4 is hydrogen or halo. In an alternative preferred embodiment, Rc4 is selected from -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)-aryl and -(C0-3 alkylene)-heteroaryl, preferably selected from -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl and -(C0-3 alkylene)-heteroaryl. Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-s alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 60 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably, Rc4 is selected from -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, and -(C0-3 alkylene)-heteroaryl, preferably from cycloalkyl, heterocycloalkyl, and heteroaryl. Said cycloalkyl, heterocycloalkyl, or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -NH(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Even more preferably, Rc4 is selected from heterocycloalkyl, and heteroaryl. Said heterocycloalkyl, or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -NH(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). In an alternative preferred embodiment, Rc4 is selected from -CH2-cycloalkyl, -CH2-cycloalkenyl, -CH2-heterocycloalkyl, -CH2-heterocycloalkenyl, -CH2-aryl and -CH2-heteroaryl, preferably selected from -CH2-cycloalkyl, -CH2-heterocycloalkyl, -CH2-aryl and -CH2-heteroaryl. Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-s alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 61 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably Rc4 is selected from -CH2-heterocycloalkyl, and -CH2-heteroaryl. Said heterocycloalkyl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). If Rc4 is heteroaryl, Rc4 is preferably imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or indazolyl, wherein heteroaryl may be optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-s haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-s alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). If Rc4 Is heterocycloalkyl, Rc4 is preferably morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6- dihydropyridinyl, or piperazinyl, wherein heterocycloalkyl is optionally 62 substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci^ alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci^ alkyl), -(C1-5 alkylene)-N (Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl, preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci^ haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). More preferably, Rc4 is piperazinyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci^ haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-s alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(A / -heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 63 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Even more preferably, Rc4 is piperazinyl (preferably N-piperazinyl) optionally substituted (preferably N-substituted) with -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Most preferably, Rc4 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. If Rc4 is heterocycloalkenyl, Rc4 is oxacyclohexenyl or azacyclohexenyl, preferably Rc4 is azacyclohexenyl, wherein heterocycloalkenyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci^ alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-s alkyl)CONH-(Ci-s alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-5 alkyl, preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). In an alternative embodiment wherein Rc4 is heterocycloalkyl, Rc4 is preferably 2-oxaspiro[3.5]non-6-en-7-yl, 2-oxaspiro[3.5]non-7-yl, 2-oxa-8-azaspiro[4.5]dec-8-yl, 9-oxa-3-azaspiro[5.5]undec-3-yl, 2-oxa-6-azaspiro[3.4]oct-6-yl, 1 -oxa-7-azaspiro[3.5]non-7-yl, 1 -oxa-8-64 azaspiro[4.5]dec-8-yl, 6-oxa-2-azaspiro[3.3]hept-2-yl, 2,8-diazaspiro[4.5]dec-8-yl, 7-oxa-3-azabicyclo[3.3.0]oct-3-yl, 8-oxa-3-azabicyclo[4.3.0]non-3-yl, 2-oxa-6-azaspiro[3.5]non-6-yl, 7-oxo-3,6,8-triazabicyclo[4.3.0]non-3-yl, 3-pyrrolino[3,4-c]pyrazol-2-yl, 3,6- diazabicyclo[3.1.1]hept-3-yl, or 2,7-diazaspiro[3.5]non-7-yl. Preferably, if X2 comprises cycloalkyl, heterocycloalkyl, aryl or heteroaryl, X4 is C-Rc4 wherein Rc4 is selected from hydrogen, halo, C1-6 alkyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), and C1-6 haloalkyl. More preferably, if X2 comprises cycloalkyl, heterocycloalkyl, aryl or heteroaryl, X4 is C-Rc4 wherein Rc4 is selected from hydrogen, and halo. Further preferably, if X4 comprises cycloalkyl, heterocycloalkyl, aryl or heteroaryl, X2 does not comprise any of the groups cycloalkyl, heterocycloalkyl, aryl and heteroaryl. Further preferably, if X2 comprises cycloalkyl, heterocycloalkyl, aryl or heteroaryl and X4 comprises cycloalkyl, heterocycloalkyl, aryl or heteroaryl, then together Rc4 and -Yc2-Rc2 include not more than 12 non-hydrogen atoms, preferably not more than 10 non-hydrogen atoms. Xs is N or C-Rcs. Preferably not more than one of X4 and X5 is N. In certain preferred embodiments, X4 is N and X5 is C-Rcs, preferably X4 is N and Xs is CH. In certain preferred embodiments, X4 is C-Rc4 and X5 is N, preferably X4 is CH and X5 is N. In certain preferred embodiments, X4 is C-Rc4 and X5 is C-Rcs. In certain preferred embodiments X4 is CH and Xs is CH. Res is selected from hydrogen, halo, C1-6 alkyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(C1-6 alkyl), -N(Ci-6 alkyl)Ci-6 alkyl and C1-6 haloalkyl. Preferably, Res is selected from hydrogen, halo, C1-3 alkyl, -O(Ci-3 alkyl), -S(Ci-3 alkyl), -NH(Ci-3 alkyl), and C1-3 haloalkyl. More preferably, Res is selected from hydrogen, halo, C1-3 alkyl, and C1-3 haloalkyl. R4 is Yrs-Rrs. Yrs is selected from a covalent bond, Cm alkylene, C24 alkenylene, and C2-4 alkynylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-s alkyl), -SO(Ci-5 alkyl), -SO2(Ci-s alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-s haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), and -N(Ci-s haloalkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -S(Ci-s alkyl), -SO(Ci-s alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-s haloalkyl), -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), and -N(Ci-s haloalkyl)(Ci-s alkyl), more preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-s haloalkyl), -S(Ci-s alkyl), -S(Ci-s haloalkyl), -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), and -N(Ci-s haloalkyl)(Ci-s alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group 65 independently selected from -0-, NH-, N(Ci-5 alkyl)-, CO-, -C00-, S-, -SO-, and SO2-, preferably selected from -0-, NH-, N(Ci-s alkyl)-, CO-, S-, -SO-, and SO2-. Preferably, Yrs is selected from a covalent bond, C1-2 alkylene, -C0-(Ci-2 alkylene)-, -(C1-2 alkylene)-CO-, -C0NH-(Ci-2 alkylene)-, -(C1-2 alkylene)-CONH-, -NHCO-(Ci-2 alkylene)-, -(C1-2 alkylene)-NHCO-, -NH-(Ci-2 alkylene)-, -(C1-2 alkylene)-NH-, -O-(Ci-2 alkylene)-, -(C1-2 alkylene)-O-, SO2-(Ci-2 alkylene)-, -(C1-2 alkylene)S02-, -CONH-, CON(Ci-s alkyl)-, -NHCO-, -N(Ci-5 alkyl)CO-, -NH-, -0-, -CO-, -COO- and -SO2-. C1-2 alkylene is herein preferably a -CH2-group. Rrs is selected from C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, preferably selected from C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Preferably Rrs is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. More preferably, Rrs is selected from heterocycloalkyl, aryl, and heteroaryl. Even more preferably, Rrs is selected from aryl and heteroaryl. Most preferably, Rrs is heteroaryl. Said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-s haloalkyl), NH21, NH(Ci-5 alkyl), NH(Ci-s haloalkyl), N(Ci-s alkyl)(Ci-5 alkyl), N(Ci-s haloalkyl)(Ci-s alkyl), CONH2, CONH(Ci-5 alkyl), and CON(Ci-s alkyl)(Ci-s alkyl). Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-s haloalkyl), -SO(Ci-s haloalkyl), -SO2(Ci-s haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -C0NH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-s alkyl)(Ci-s alkyl). Preferably, Yrs is selected from a covalent bond, C1-2 alkylene, -C0-(Ci-2 alkylene)-, -(C1-2 alkylene)-CO-, -CONH-(Ci-2 alkylene)-, -(C1-2 alkylene)-CONH-, -NHCO-(Ci-2 alkylene)-, -(C1-2 alkylene)-NHCO-, -NH-(Ci-2 alkylene)-, -(C1-2 alkylene)-NH-, -O-(Ci-2 alkylene)-, -(C1-2 alkylene)-O-, SO2-(Ci-2 alkylene), -(C1-2 alkylene)S02-, -CONH-, -NHCO-, -NH-, -0-, -CO- and SO2-. Thus, preferably, R4 is selected from -(C0-2 alkylene)-cycloalkyl, -CO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CO-cycloalkyl, -CONH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CONH-cycloalkyl, -NHCO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NHCO-cycloalkyl, -NH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NH-cycloalkyl, -0-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-O-cycloalkyl, S02-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)S02-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, SO2-66 cycloalkyl, -(C0-2 alkylene)-cycloalkenyl, -CO-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-CO-cycloalkenyl, -CONH-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-CONH-cycloalkenyl, -NHCO-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-NHCO-cycloalkenyl, -NH-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-NH-cycloalkenyl, -0-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-O-cycloalkenyl, S02-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, SO2-cycloalkenyl, -(C0-2 alkylene)-heterocycloalkyl, -CO-(C0-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CO-heterocycloalkyl, -CONH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NH-heterocycloalkyl, -0-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-O-heterocycloalkyl, S02-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, SO2-heterocycloalkyl, -(C0-2 alkylene)-heterocycloalkenyl, -CO-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-CO-heterocycloalkenyl,     -CONH-(Co-2    alkylene)-heterocycloalkenyl,     -(C0-2    alkylene)-CONH- heterocycloalkenyl,     -NHCO-(Co-2    alkylene)-heterocycloalkenyl,     -(C0-2    alkylene)-NHCO- heterocycloalkenyl, -NH-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-NH-heterocycloalkenyl, -0-(C0-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-O-heterocycloalkenyl, S02-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, SO2-heterocycloalkenyl, -(C0-2 alkylene)-aryl, -CO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(C0-2 alkylene)-aryl, -(C0-2 alkylene)-NH-aryl, -0-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-O-heteroaryl, S02-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)S02-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl, preferably selected from -(C0-2 alkylene)-cycloalkyl, -CO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CO-cycloalkyl, -CONH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CONH-cycloal kyl, -NHCO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NHCO-cycloalkyl, -NH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NH-cycloalkyl, -0-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-O-cycloalkyl, S02-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-67 cycloalkyl, SO2-cycloalkyl, -(C0-2 alkylene)-heterocycloalkyl, -CO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CO-heterocycloalkyl, -CONH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NHCO-heterocycloalkyl, -NH-(C0-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NH-heterocycloalkyl, -0-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-O-heterocycloalkyl, S02-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)S02-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, SO2-heterocycloalkyl, -(C0-2 alkylene)-aryl, -CO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NH-aryl, -0-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-O-heteroaryl, S02-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl. Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-s haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-s alkyl), O(Cis haloalkyl), SH, S(Cis alkyl), S(Cis haloalkyl), NH2, NH(Ci-5 alkyl), NH(Cis haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), and CON(Ci-s alkyl)(Ci-5 alkyl). More preferably, R4 is selected from -(C0-2 alkylene)-aryl, -CO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NH-aryl, -0-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-O-heteroaryl, S02-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl, 68 wherein said aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-5 alkyl), O(Cis haloalkyl), SH, S(Ci5 alkyl), S(Ci5 haloalkyl), NH2, NH(Ci^ alkyl), NH(Cis haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), and CON(Ci-5 alkyl)(Ci-5 alkyl). In certain embodiments, R4 is selected from -(Co-2 alkylene)-CO-cycloalkyl, preferably -COcyclohexyl, and -(Co-2 alkylene)-CO-aryl, preferably -CO-phenyl. In certain embodiments, R4 is selected from -COO-(Ci-5 alkyl) or -CONH-(Ci-5 alkyl). In one specific embodiment, R4 is selected from: Preferably, Yrs is a covalent bond. Thus, R4 is preferably selected from Ci-i2 alkyl, C2-i2 alkenyl, C2-i2 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, more preferably selected from Ci-i2 alkyl, C2-i2 alkenyl, C2-i2 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. More preferably, R4 is selected from cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl. More preferably, R4 is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl. Even more preferably, R4 is selected from aryl, and heteroaryl. Most preferably, R4 is heteroaryl. Said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), SH, -S(Ci-s alkyl), -S(Ci-s haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-s alkyl)(Ci-s alkyl). Said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably, R4 is a five membered heteroaryl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci^ alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci^ haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci^ alkyl). The said five membered heteroaryl is preferably selected from imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl. More preferably, said five membered heteroaryl is1,2,4-thiadiazolyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci^ haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), preferably optionally substituted with C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -SH, -S(Ci-5 alkyl), more preferably optionally substituted with C1-5 alkyl, C1-5 haloalkyl, even more preferably optionally substituted with C1-5 haloalkyl, preferably selected from -CH2F, -CHF2 and CF3, most preferably optionally substituted with -CHF2. In one specific embodiment, R4 is >---- / . Preferably, the present invention relates to a compound of formula (I) wherein W is -NHS(O)2-. Thus, in another embodiment, the present invention relates to a compound of formula (la): J I X: (la) Ri, R2, R3, R4, Xi, X2, X3, X4, and X5 in the compound of formula (la) are as defined hereinabove for the compound of formula (I). In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus, preferably, the compound of formula (la) is a compound of formula (lb): Ri, R4, Xi, X2, X3, X4, and Xs in the compound of formula (lb) are as defined hereinabove for the compound of formula (I). Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl (Ci-2)haloalkyl, -(C1-2 alkylene)-OH and -(C1-2 alkylene)-O-(Ci-2 alkyl). Preferably, Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (C1-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus, in a preferred embodiment, the compound of formula (lb) is a compound of formula (Ic): (Ic) R4, Xi, X2, X3, X4, and Xs in the compound of formula (Ic) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, the compound of formula (I) or the compound of formula (la) or the compound of formula (lb) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Within the scope of the present invention, the compound of formula (I) or the compound of formula (la) or the compound of formula (lb) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Preferably, within the scope of the present invention, Xi and X3 are each CH. Thus, preferably the compound of formula (I) of the present invention is a compound of formula (Id): (Id) W, Ri, R2, R3, R4, X2, X4, and X5 in the compound of formula (Id) are as defined hereinabove for the compound of formula (I). Preferably, the present invention relates to a compound of formula (I) wherein W is -NHS(O)2-. Thus, in another embodiment, the compound of formula (Id) of the present invention is a compound of formula (Ie): Ri, R2, R3, R4, X2, X4, and X5 in the compound of formula (Ie) are as defined hereinabove for the compound of formula (I). In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus, preferably, the compound of formula (Ie) of the present invention is a compound of formula (If): (If) Ri, R4, X2, X4, and X5 in the compound of formula (If) is defined as defined hereinabove for the compound of formula (I) of the present invention. Within the scope of the present invention, Ri is preferably selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (Ci-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus preferably, the compound of formula (If) of the present invention is a compound of formula (ig): (ig) R4, X2, X4, and X5 in the compound of formula (Ig) are as defined hereinabove for the compound of formula (I) of the present invention. Within the scope of the present invention, the compound of formula (Id) or the compound of formula (Ie) or the compound of formula (If) wherein Ri is methyl is also encompassed within the present invention. In certain preferred embodiments of the present invention, Ri is methyl. Within the scope of the present invention, the compound of formula (Id) or the compound of formula (Ie) or the compound of formula (If) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. As encompassed by the present invention, X4 is N or C-Rc4 and X5 is N or C-Rcs. Furthermore, as defined hereinabove, preferably not more than one of X4 and X5 is N. In certain embodiments of the present invention, X5 is N. Thus, if X5 is N, preferably X4 is C-Rc4. Thus, in certain preferred embodiments the compound of formula (I) is a compound of formula (Ih): R4 RC4 (Ih) W, Rc4, Ri, R2, R3, R4, Xi, X2, and X3 in the compound of formula (Ih) are as defined hereinabove for the compound of formula (I). Preferably, within the scope of the present invention W is -NHS(O)2-. Thus, preferably, the compound of formula (I) or the compound of formula (la) or the compound of formula (Ih) is a compound of formula (li): Rc4 Rc4, Ri, R2, R3, R4, Xi, X2, and X3 in the compound of formula (li) are as defined hereinabove for the compound of formula (I). In a preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus, preferably, the compound of formula (li) of the present invention is a compound of formula (Ij): (lj) Rc4, Ri, R4, Xi, X2, and X3 in the compound of formula (Ij) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, preferably Ri is hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (Ci-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus, preferably within the scope of the present invention the compound of formula (I) or the compound of formula (lb) or the compound of formula (Ic) or the compound of formula (Ih) or the compound of formula (li) or the compound of formula (Ij) of the present invention is a compound of formula (Ik): RC4 (Ik) Rc4, R4, Xi, X2, and X3 in the compound of formula (Ik) are as defined hereinabove for the compound of formula (I). In one embodiment of the compound of formula (I) of the present invention, Xi and X3 are each CH. Thus, preferably the compound of formula (I) of the present invention is a compound of formula (IL): R4 RC4 (IL) W, Rc4, Ri , R2, R3, R4, and X2 in the compound of formula (IL) are as defined hereinabove for the compound of formula (I). Preferably, within the scope of the present invention W is -NHS(O)2-. Thus, preferably, the compound of formula (IL) of the present invention is a compound of formula (Im): RC4 (Im) Rc4, Ri, R2, R3, R4, and X2 in the compound of formula (IL) are as defined hereinabove for the compound of formula (I). Preferably, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus, preferably, the compound of formula (Im) of the present invention is a compound of formula (In): RC4 (In) Rc4, Ri, R4, and X2 in the compound of formula (In) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, preferably Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (Ci-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus, preferably within the scope of the present invention the compound of formula (In) is a compound of formula (Io): Rc4 (Io) Rc4, R4, and X2 in the compound of formula (Io) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, the compound of formula (IL) or the compound of formula (Im) or the compound of formula (In) wherein Ri is methyl is also encompassed within the present invention. In certain preferred embodiments of the present invention, Ri is methyl. Alternatively, within the scope of the present invention, the compound of formula (IL) or the compound of formula (Im) or the compound of formula (In) wherein Ri is fluoromethyl is also encompassed within the present invention. In certain preferred embodiments of the present invention, Ri is fluoromethyl. In one embodiment of the compound of formula (I) of the present invention R4 is selected from aryl, and heteroaryl. Most preferably, R4 is heteroaryl. Said aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). Preferably, R4 is a five membered heteroaryl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci^ alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl). The said five membered heteroaryl is preferably selected from imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl. More preferably, said five membered heteroaryl is1,2,4-thiadiazolyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably optionally substituted with C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -SH, -S(Ci-5 alkyl), more preferably optionally substituted with C1-5 alkyl, C1-5 haloalkyl, even more preferably optionally substituted with C1-5 haloalkyl, preferably selected from -CH2F, -CHF2 and CF3, most preferably optionally substituted with -CHF2. Thus, in a preferred embodiment, the compound of formula (I) is a compound of formula (Ip): 76 (IP) W, Ri, R2, R3, Xi, X2, X3, X4, and X5 in the compound of formula (Ip) are as defined hereinabove for the compound of formula (I). Preferably W is -NHS(O)2-. Thus, within the scope of the present invention, the compound of formula (Ip) is a compound of formula (Iq): (lq) Ri, R2, R3, Xi, X2, X3, X4, and X5 in the compound of formula (Io) are as defined hereinabove for the compound of formula (I). In a further preferred embodiment, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus, in a preferred embodiment, the compound of formula (Iq) of the present invention is a compound according to formula (Ir): (lr) Ri, Xi, X2, X3, X4, and X5 in the compound of formula (Ir) are as defined hereinabove for the compound of formula (I). Further preferably, Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. Preferably, Ri is selected from the group consisting of cyano, (Ci-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus, preferably within the scope of the present invention the compound of formula (Ir) is a compound of formula (Is): Xi, X2, X3, X4, and Xs in the compound of formula (Ir) are as defined hereinabove for the compound of formula (I). It is noted that within the scope of the present invention, the compound of formula (Ip) or the compound of formula (Iq) or the compound of formula (Ir) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. It is further noted that alternatively within the scope of the present invention, the compound of formula (Ip) or the compound of formula (Iq) or the compound of formula (Ir) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Further preferred within the scope of the present invention are embodiments wherein Xi and X3 are each CH. Thus, the compound of formula (Ip) of the present invention further relates to an embodiment wherein the compound of formula (Ip) is a compound of formula (It): W, Ri, R2, R3, X2, X4, and X5 in the compound of formula (It) are as defined hereinabove for the compound of formula (I). Preferably, W is -NHS(O)2-. Thus further within the scope of the present invention, the compound of formula (Iq) of the present invention further relates to an embodiment wherein the compound of formula (Iq) is or a compound of formula (lu), (lu) Ri, R2, R3, X2, X4, and X5 in the compound of formula (lu) are as defined hereinabove for the compound of formula (I). Preferably in the compound of formula (lu) R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. As thus further encompassed by the present invention, the compound of formula (Ir) of the present invention further relates to an embodiment wherein the compound of formula (Ir) is a compound of formula (Iv), Ri, X2, X4, and X5 in the compound of formula (Iv) are as defined hereinabove for the compound of formula (I). As preferably Ri is cyano, the compound of formula (Is) of the present invention further relates to an embodiment wherein the compound of formula (Is) is or a compound of formula (Iw) N chf2 n" (Iw) X2, X4, and X5 in the compound of formula (Iw) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, the compound of formula (It) or the compound of formula (lu) or the compound of formula (Iv) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Alternatively, within the scope of the present invention, the compound of formula (It) or the compound of formula (lu) or the compound of formula (Iv) 79 wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. As encompassed by the present invention, X4 is N or C-Rc4 and X5 is N or C-Rcs. Furthermore, as defined hereinabove, preferably not more than one of X4 and X5 is N. In certain embodiments of the present invention, X5 is N. Thus, if X5 is N, preferably X4 is C-Rc4. Thus, in certain preferred embodiments the compound of formula (It) is a compound of formula (lx): Rc4 (lx) W, Rc4, Ri, R2, R3, and X2 in the compound of formula (lx) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably within the scope of the present invention W is -NHS(O)2-, in certain preferred embodiments the compound of formula (lu) is a compound of formula (ly): Rc4 (iy) Rc4, Ri, R2, R3, and X2 in the compound of formula (ly) are as defined hereinabove for the compound of formula (I). Preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus further accordingly, in certain preferred embodiments the compound of formula (Iv) is a compound of formula (Iz): Rc4 (Iz) Rc4, Ri, and X2 in the compound of formula (Iz) are as defined hereinabove for the compound of formula (I). Within the scope of the present invention, preferably Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl. More preferably, Ri is selected from the group consisting of cyano, (Ci-2)haloalkyl and (Ci-2)alkyl, preferably cyano, fluoromethyl and methyl. More preferably, Ri is cyano. Thus further accordingly, in certain preferred embodiments the compound of formula (Iw) is a compound of formula (laa): (laa) Rc4, and X2 in the compound of formula (laa) are as defined hereinabove for the compound of formula (I). It is however noted that within the scope of the present invention, the compound of formula (lx) or the compound of formula (ly) or the compound of formula (Iz) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. It is further noted that alternatively within the scope of the present invention, the compound of formula (lx) or the compound of formula (ly) or the compound of formula (Iz) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Preferably within the scope of the present invention X2 is C-Yc2-Rc2. Most preferably, -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. Thus, preferably the compound of formula (I) of the present invention is a compound of formula (lab): O^N(CH3)2 (lab) W, Ri, R2, R3, R4, Xi, X3, X4, and X5 in the compound of formula (lab) are as defined for the compound of formula (I) of the present invention. Preferably W is -NHS(O)2-. Accordingly, preferably the compound of formula (la) of the present invention or the compound of formula (lab) is a compound of formula (lac): Rs Ri C< N(CH3)2 (lac) Ri, R2, R3, R4, Xi, X3, X4, and X5 in the compound of formula (lac) are as defined for the compound of formula (I) of the present invention. Preferably, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus further accordingly, preferably the compound of formula (lac) or the compound of formula (lb) of the present invention is a compound of formula (lad): <1 ck .0 F4 >k x3 / R< NH I I X5 x^y^ 0 O^N(CH3)2 (lad) Ri, R4, Xi, X3, X4, and X5 in the compound of formula (lad) are as defined for the compound of formula (I) of the present invention. Further accordingly, preferably, Ri is cyano, thus preferably the compound of formula (Ic) of the present invention or the compound of formula (lad) of the present invention is a compound of formula (lae): CK N(CH3)2 (lae) R4, Xi, X3, X4, and Xs in the compound of formula (lae) are as defined for the compound of formula (I) of the present invention. It is however noted that within the scope of the present invention, the compound of formula (lab) or the compound of formula (lac) or the compound of formula (lad) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Alternatively, it is noted that within the scope of the present invention, the compound of formula (lab) or the compound of formula (lac) or the compound of formula (lad) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Further preferred within the scope of the present invention are embodiments wherein Xi and X3 are each CH. Thus, accordingly the compound of formula (lac) of the present invention is preferably a compound of formula (lag): (laf) W, Ri, R2, R3, R4, X4, and X5 in the compound of formula (laf) are as defined for the compound of formula (I) of the present invention. Preferably W is -NHS(O)2-. Further accordingly, the compound of formula (lad) of the present invention or the compound of formula (laf) as defined herein is preferably a compound of formula (lag): (lag) Ri, R2, R3, R4, X4, and Xs in the compound of formula (lag) are as defined for the compound of formula (I) of the present invention. Preferably, R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Further accordingly, the compound of formula (lae) or the compound of formula (lag) of the present invention is preferably a compound of formula (lah): (lah) Ri, R4, X4, and Xs in the compound of formula (lah) are as defined for the compound of formula (I) of the present invention. Preferably, Ri is cyano. Thus, further accordingly, the compound of formula (laf) of the present invention or the compound of formula (lah) of the present invention is preferably a compound of formula (lai): (laj) R4, X4, and Xs in the compound of formula (lai) are as defined for the compound of formula (I) of the present invention. Within the scope of the present invention, the compound of formula (laf) or the compound of formula (lag) or the compound of formula (lah) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Alternatively, within the scope of the present invention, the compound of formula (laf) or the compound of formula (lag) or the compound of formula (lah) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. As further encompassed by the present invention, X4 is N or C-Rc4 and X5 is N or C-Rcs. Furthermore, as defined hereinabove, preferably not more than one of X4 and X5 is N. In certain embodiments of the present invention, Xs is N. Thus, if X5 is N, preferably X4 is C-Rc4. Thus accordingly, the compound of formula (lab) of the present invention is preferably a compound of formula (laj): N(CH3)2 (laj) W, Rc4, Ri, R2, R3, R4, Xi, and X3 in the compound of formula (laj) are as defined for the compound of formula (I) of the present invention. W is preferably -NHS(O)2-. Thus further accordingly, the compound of formula (lac) or the compound of formula (laj) of the present invention is preferably a compound of formula (lak): C< N(CH3)2 (lak) Rc4, Ri, R2, R3, R4, Xi, and X3 in the compound of formula (lak) are as defined for the compound of formula (I) of the present invention. As disclosed herein, preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl. Thus further accordingly, the compound of formula (lad) or the compound of formula (lak) of the present invention is preferably a compound of formula (laL): (laL) Rc4, Ri, R4, Xi, and X3 in the compound of formula (laL) are as defined for the compound of formula (I) of the present invention. Further preferably Ri is cyano. Thus further accordingly, the compound of formula (lae) or the compound of formula (laL) of the present invention is preferably a compound of formula (lam): N(CH3)2 (lam) Rc4, R4, Xi, and X3 in the compound of formula (lam) are as defined for the compound of formula (I) of the present invention. Within the scope of the present invention, the compound of formula (laj) or the compound of formula (lak) or the compound of formula (laL) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Further within the scope of the present invention, the compound of formula (laj) or the compound of formula (lak) or the compound of formula (laL) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Further accordingly, the compound of formula (laf) of the present invention is preferably a compound of formula (Ian): (Ian) W, Ri, R2, R3, R4, and Rc4 in the compound of formula (Ian) are as defined for the compound of formula (I) of the present invention. Further accordingly, the compound of formula (lag) of the present invention is preferably a compound of formula (lao): Ri, R2, R3, R4, and Rc4 in the compound of formula (lao) are as defined for the compound of formula (I) of the present invention. Further accordingly, the compound of formula (lah) of the present invention is preferably a compound of formula (lap): N(CH3)2 (lap) Ri, R4, and Rc4 in the compound of formula (lap) are as defined for the compound of formula (I) of the present invention. Further accordingly, the compound of formula (lai) of the present invention is preferably a compound of formula (lag): (laq) R4, and Rc4 in the compound of formula (laq) are as defined for the compound of formula (I) of the present invention. As further encompassed by the present invention, X4 is N or C-Rc4 and X5 is N or C-Rcs. Furthermore, as defined hereinabove, preferably not more than one of X4 and Xs is N. In certain embodiments of the present invention, X4 is N. Thus, if X4 is N, preferably X5 is C-Rcs. Thus accordingly, in certain preferred embodiments of the present invention, the compound of formula (I) of the present invention is a compound of formula (lar): W, Ri, R2, R3, R4, Xi, X2, X3, and Res in the compound of formula (lar) are as defined for the compound of formula (I) of the present invention. Further accordingly, as W is preferably -NHS(O)2-, in certain preferred embodiments of the present invention, the compound of formula (la) of the present invention is a compound of formula (las): R3                 p r2. ।       .0 r4 Ri NH I I ---Rc5 SA (las) Ri, R2, R3, R4, Xi, X2, X3, and Res in the compound of formula (lar) are as defined for the compound of formula (I) of the present invention. Further accordingly, as preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl, in certain preferred embodiments of the present invention, the compound of formula (lb) of the present invention is a compound of formula (lat): (lat) Ri, R4, Xi, X2, X3, and Res in the compound of formula (lat) are as defined for the compound of formula (I) of the present invention. Further accordingly, as preferably Ri is cyano, in certain preferred embodiments of the present invention, the compound of formula (Ic) of the present invention is a compound of formula (lau): (lau) R4, Xi, X2, X3, and Res in the compound of formula (lau) are as defined for the compound of formula (I) of the present invention. However, within the scope of the present invention, the compound of formula (lar) or the compound of formula (las) or the compound of formula (lat) wherein Ri is methyl is also encompassed. In certain preferred embodiments of the present invention, Ri is methyl. Further within the scope of the present invention, the compound of formula (lar) or the compound of formula (las) or the compound of formula (lat) wherein Ri is fluoromethyl is also encompassed. In certain preferred embodiments of the present invention, Ri is fluoromethyl. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Id) of the present invention is a compound of formula (lav): (lav) W, Ri, R2, R3, R4, X2, and Res in the compound of formula (lav) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Ie) of the present invention is a compound of formula (law): (law) Ri, R2, R3, R4, X2, and Res in the compound of formula (law) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (If) of the present invention is a compound of formula (lax): (lax) Ri, R4, X2, and Res in the compound of formula (lax) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Ig) of the present invention is a compound of formula (lay): (lay) R4, X2, and Res in the compound of formula (lay) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Ip) of the present invention is a compound of formula (laz): (laz) W, Ri, R2, R3, Xi, X2, X3, and Res in the compound of formula (laz) are as defined for the compound of formula (I) of the present invention. Further accordingly, as preferably W is -NHS(O)2-, in certain preferred embodiments of the present invention, the compound of formula (Iq) of the present invention is a compound of formula (Iba): (Iba) Ri, R2, R3, Xi, X2, X3, and Res in the compound of formula (Iba) are as defined for the compound of formula (I) of the present invention. Further accordingly, as preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl, in certain preferred embodiments of the present invention, the compound of formula (Ir) of the present invention is a compound of formula (Ibb): (Ibb) Ri, X2, and Res in the compound of formula (Ibb) are as defined for the compound of formula (I) of the present invention. Further accordingly, as preferably Ri is cyano, in certain preferred embodiments of the present invention, the compound of formula (Is) of the present invention is a compound of formula (Ibc): (Ibc) Further preferred within the scope of the present invention are embodiments wherein Xi and X3 are each CH. Thus, in certain preferred embodiments, the compound of formula (It) is a compound of formula (Ibd): (Ibd) W, Ri, R2, R3, X2, and Res in the compound of formula (Ibd) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (lu) of the present invention is a compound of formula (Ibe): N chf2 n" ¾T RC5 (Ibe) Ri, R2, R3, X2, and Res in the compound of formula (Ibe) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Iv) of the present invention is a compound of formula (Ibf): (Ibf) Ri, X2, and Res in the compound of formula (Ibf) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention, the compound of formula (Iw) of the present invention is a compound of formula (Ibg): (Ibg) X2 and Res in the compound of formula (Ibf) are as defined for the compound of formula (I) of the present invention. In certain embodiments of the present invention, preferably X2 is C-Yc2-Rc2. Most preferably, -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. Thus accordingly, in certain preferred embodiments of the present invention the compound of formula (lab) is a compound of formula (Ibh): r3 r2 X3. RC5 N(CH3)2 (Ibh) W, Ri, R2, R3, R4, Xi, X3 and Res in the compound of formula (Ibh) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lac) is a compound of formula (Ibi): r2 Ri Rc3 N(CH3)2 (Ibi) Ri, R2, R3, R4, Xi, X3 and Res in the compound of formula (Ibi) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lad) is a compound of formula (Ibj): (Ibj) Ri, R4, Xi, X3 and Res in the compound of formula (Ibi) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lae) is a compound of formula (Ibk): (Ibk) R4, Xi, X3 and Res in the compound of formula (Ibi) are as defined for the compound of formula (I) of the present invention. Further preferred within the scope of the present invention are embodiments wherein Xi and X3 are each CH. Thus, in certain preferred embodiments, the compound of formula (laf) is a compound of formula (IbL): (IbL) W, Ri, R2, R3, R4, and Res in the compound of formula (IbL) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lag) is a compound of formula (Ibm): r2 Ri N(CH3)2 Rc5 Ri, R2, R3, R4, and Res in the compound of formula (Ibm) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lah) is a compound of formula (Ibn): < 0. R< NH Rc5 O' N(CH3)2 (Ibn) Ri, R4, and Res in the compound of formula (Ibn) are as defined for the compound of formula (I) of the present invention. Further accordingly, in certain preferred embodiments of the present invention the compound of formula (lai) is a compound of formula (Ibo): N(CH3)2 (Ibo) R4, and Res in the compound of formula (Ibn) are as defined for the compound of formula (I) of the present invention. In certain embodiments of the present invention, Xi is CF and X3 is CH. Thus, the compound of formula (I) is a compound of formula (Ibp): R4 r< I i x5 ri A AYZ (Ibp) W, Ri, R2, R3, R4, X2, X4, and X5 in the compound of formula (Ibp) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably W is -NHS(O)2-, in certain preferred embodiments of the present invention, the compound of formula (Ibp) of the present invention is a compound of formula (Ibq): R2^ As>° 74 r^nh" ''A'A a xr (Ibq) Ri, R2, R3, R4, X2, X4, and X5 in the compound of formula (Ibq) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl, in certain preferred embodiments of the present invention, the compound of formula (Ibq) of the present invention is a compound of formula (Ibr): <1 0. .0 F4 A       / R< NH I X / 5 (Ibr) Ri, R4, X2, X4, and X5 in the compound of formula (Ibr) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably Ri is cyano, in certain preferred embodiments of the present invention, the compound of formula (Ibr) of the present invention is a compound of formula (lbs): R4, X2, X4, and X5 in the compound of formula (lbs) are as defined hereinabove for the compound of formula (I). It is however noted that the compounds of formula (Ibp), (Ibq) or (Ibr) wherein Ri is methyl or fluoromethyl are also encompassed within the scope of the present invention. In certain embodiments of the present invention, preferably X2 is C-Yc2-Rc2. Most preferably, -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2. Thus accordingly, in certain embodiments of the present invention the compound of formula (Ibp) is a compound of formula (Ibt): R4 X     N V- R2 I                I x5 Ri X. XY / 0 N O XN(C1 R); (Ibt) W, Ri, R2, R3, R4, X4, and X5 in the compound of formula (Ibt) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (Ibq) is a compound of formula (Ibu): R3                R r2Xi‘             r X x x u o'XN(CH3)2 (Ibu) Ri, R2, R3, R4, X4, and X5 in the compound of formula (Ibu) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (Ibr) is a compound of formula (Ibv). (Ibv) Ri, R4, X4, and X5 in the compound of formula (Ibv) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (lbs) is a compound of formula (lbw). (lbw) R4, X4, and X5 in the compound of formula (Ibt) are as defined hereinabove for the compound of formula (I). It is however noted that the compounds of formula (Ibt), (Ibu) or (Ibv) wherein Ri is methyl or fluoromethyl are also encompassed within the scope of the present invention. In certain preferred embodiments, X4 is C-Rc4 and X5 is C-Rcs. Thus, the compound of formula (I) is in certain embodiments a compound of formula (Ibx): (Ibx) W, Ri, R2, R3, R4, Rc4, Res, Xi, X2, and X3 in the compound of formula (Ibx) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably W is -NHS(0)2-, in certain preferred embodiments of the present invention, the compound of formula (Ibx) of the present invention is a compound of formula (Iby): (Iby) Ri, R2, R3, R4, Rc4, Res, Xi, X2, and X3 in the compound of formula (Iby) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably R2 and R3 together with the carbon atom to which they are attached form cyclopropyl, in certain preferred embodiments of the present invention, the compound of formula (Iby) of the present invention is a compound of formula (Ibz): (Ibz) Ri, R4, Rc4, Res, Xi, X2, and X3 in the compound of formula (Ibz) are as defined hereinabove for the compound of formula (I). Further accordingly, as preferably Ri is cyano, in certain preferred embodiments of the present invention, the compound of formula (Ibz) of the present invention is a compound of formula (lea): (lea) R4, Rc4, Res, Xi, X2, and X3 in the compound of formula (lea) are as defined hereinabove for the compound of formula (I). It is however noted that the compounds of formula (Ibx), (Iby) or (Ibz) wherein Ri is methyl or fluoromethyl are also encompassed within the scope of the present invention. In certain preferred embodiments Xi is CH and X3 is CH. Thus accordingly, in certain embodiments of the present invention the compound of formula (Ibx) is a compound of formula (leb): Rc4 (Icb) W, Ri, R2, R3, R4, Rc4, Res, and X2 in the compound of formula (Icb) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (Iby) is a compound of formula (Icc): RC4 (Icc) Ri, R2, R3, R4, Rc4, Res, and X2 in the compound of formula (Icc) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (Ibz) is a compound of formula (led): RC4 (led) Ri, R4, Rc4, Res, and X2 in the compound of formula (led) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (lea) is a compound of formula (Ice): (Ice) R4, Rc4, Res, and X2 in the compound of formula (Ice) are as defined hereinabove for the compound of formula (I). In certain preferred embodiments X4 is CH and X5 is CH. Thus accordingly, in certain embodiments of the present invention the compound of formula (Icb) is a compound of formula (Icf): (Icf) W, Ri, R2, R3, R4, and X2 in the compound of formula (Icf) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (Icc) is a compound of formula (leg): (leg) Ri, R2, R3, R4, and X2 in the compound of formula (leg) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (led) is a compound of formula (Ich): (Ich) Ri, R4, and X2 in the compound of formula (Ich) are as defined hereinabove for the compound of formula (I). Further accordingly, in certain embodiments of the present invention the compound of formula (led) is a compound of formula (lei): (lei) R4 and X2 in the compound of formula (lei) are as defined hereinabove for the compound of formula (I). Preferred compound of formula (I) are selected from the following compounds: F enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. Further preferred compounds of formula (I) are selected from: F , or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. Further preferred compounds of formula (I) are selected from: Further preferred compounds of formula (I) are selected from: Further preferred compounds of formula (I) are selected from Further preferred compound of formula (I) is , preferably Particularly preferred are exemplified compounds, i.e. the compounds 1 to 299, as described hereinbelow. Preferably, the compound of formula (I) is selected from: The present invention also relates to each of the intermediates described further below in the examples section of this specification, including any one of these intermediates in non-salt form or in the form of a salt (e.g., a pharmaceutically acceptable salt) of the respective compound. Such intermediates can be used, in particular, in the synthesis of the compounds of formula (I). The scope of the invention embraces all pharmaceutically acceptable salt forms of the compounds of formula (I) which may be formed, e.g., by protonation of an atom carrying an electron lone pair which is susceptible to protonation, such as an amino group, with an inorganic or organic acid, or as a salt of an acid group (such as a carboxylic acid group) with a physiologically acceptable cation. Exemplary base addition salts comprise, for example: alkali metal salts such as sodium or potassium salts; alkaline earth metal salts such as calcium or magnesium salts; zinc salts; ammonium salts; aliphatic amine salts such as trimethylamine, triethylamine, dicyclohexylamine, ethanolamine, diethanolamine, triethanolamine, procaine salts, meglumine salts, ethylenediamine salts, or choline salts; aralkyl amine salts such as N,N-dibenzylethylenediamine salts, benzathine salts, benethamine salts; heterocyclic aromatic amine salts such as pyridine salts, picoline salts, quinoline salts or isoquinoline salts; quaternary ammonium salts such as tetramethylammonium salts, tetraethylammonium salts, benzyltrimethylammonium salts, benzyltriethylammonium salts, benzyltributylammonium salts, methyltrioctylammonium salts or tetrabutylammonium salts; and basic amino acid salts such as arginine salts, lysine salts, or histidine salts. Exemplary acid addition salts comprise, for example: mineral acid salts such as hydrochloride, hydrobromide, hydroiodide, sulfate salts (such as, e.g., sulfate or hydrogensulfate salts), nitrate salts, phosphate salts (such as, e.g., phosphate, hydrogenphosphate, or dihydrogenphosphate salts), carbonate salts, hydrogencarbonate salts, perchlorate salts, borate salts, or thiocyanate salts; organic acid salts such as acetate, propionate, butyrate, pentanoate, hexanoate, heptanoate, octanoate, cyclopentanepropionate, decanoate, undecanoate, oleate, stearate, lactate, maleate, oxalate, fumarate, tartrate, malate, citrate, succinate, adipate, gluconate, glycolate, nicotinate, benzoate, salicylate, ascorbate, pamoate (embonate), camphorate, glucoheptanoate, or pivalate salts; sulfonate salts such as methanesulfonate (mesylate), ethanesulfonate (esylate), 2-hydroxyethanesulfonate (isethionate), benzenesulfonate (besylate), p-toluenesulfonate (tosylate), 2-naphthalenesulfonate (napsylate), 3-phenylsulfonate, or camphorsulfonate salts; glycerophosphate salts; and acidic amino acid salts such as aspartate or glutamate salts. Preferred pharmaceutically acceptable salts of the compounds of formula (I) include a hydrochloride salt, a hydrobromide salt, a mesylate salt, a sulfate salt, a tartrate salt, a fumarate salt, an acetate salt, a citrate salt, and a phosphate salt. A particularly preferred pharmaceutically acceptable salt of the compound of formula (I) is a hydrochloride salt. Accordingly, it is preferred that the compound of formula (I), including any one of the specific compounds of formula (I) described herein, is in the form of a hydrochloride salt, a hydrobromide salt, a mesylate salt, a sulfate salt, a tartrate salt, a fumarate salt, an acetate salt, a citrate salt, or a phosphate salt, and it is particularly preferred that the compound of formula (I) is in the form of a hydrochloride salt. The present invention also specifically relates to the compound of formula (I), including any one of the specific compounds of formula (I) described herein, in non-salt form. Moreover, the scope of the invention embraces the compounds of formula (I) in any solvated form, including, e.g., solvates with water (i.e., as a hydrate) or solvates with organic solvents such as, e.g., methanol, ethanol, isopropanol, acetic acid, ethyl acetate, ethanolamine, DMSO, or acetonitrile. All physical forms, including any amorphous or crystalline forms (i.e., polymorphs), of the compounds of formula (I) are also encompassed within the scope of the invention. It is to be understood that such solvates and physical forms of pharmaceutically acceptable salts of the compounds of the formula (I) are likewise embraced by the invention. Furthermore, the compounds of formula (I) may exist in the form of different isomers, in particular stereoisomers (including, e.g., geometric isomers (or cis / trans isomers), enantiomers and diastereomers) or tautomers (including, in particular, prototropic tautomers, such as keto / enol tautomers or thione / thiol tautomers). All such isomers of the compounds of formula (I) are contemplated as being part of the present invention, either in admixture or in pure or substantially pure form. As for stereoisomers, the invention ill embraces the isolated optical isomers of the compounds according to the invention as well as any mixtures thereof (including, in particular, racemic mixtures / racemates). The racemates can be resolved by physical methods, such as, e.g., fractional crystallization, separation or crystallization of diastereomeric derivatives, or separation by chiral column chromatography. The individual optical isomers can also be obtained from the racemates via salt formation with an optically active acid followed by crystallization. The present invention further encompasses any tautomers of the compounds of formula (I). It will be understood that some compounds may exhibit tautomerism. In such cases, the formulae provided herein expressly depict only one of the possible tautomeric forms. The formulae and chemical names as provided herein are intended to encompass any tautomeric form of the corresponding compound and not to be limited merely to the specific tautomeric form depicted by the drawing or identified by the name of the compound. The scope of the invention also embraces compounds of formula (I), in which one or more atoms are replaced by a specific isotope of the corresponding atom. For example, the invention encompasses compounds of formula (I), in which one or more hydrogen atoms (or, e.g., all hydrogen atoms) are replaced by deuterium atoms (i.e., 2H; also referred to as “D”). Accordingly, the invention also embraces compounds of formula (I) which are enriched in deuterium. Naturally occurring hydrogen is an isotopic mixture comprising about 99.98 mol-% hydrogen-1 (1H) and about 0.0156 mol-% deuterium (2H or D). The content of deuterium in one or more hydrogen positions in the compounds of formula (I) can be increased using deuteration techniques known in the art. For example, a compound of formula (I) or a reactant or precursor to be used in the synthesis of the compound of formula (I) can be subjected to an H / D exchange reaction using, e.g., heavy water (D2O). Further suitable deuteration techniques are described in: Atzrodt J et al., Bioorg Med Chem, 20(18), 5658-5667,2012; William JS et al., Journal of Labelled Compounds and Radiopharmaceuticals, 53(11-12), 635-644,2010; Modvig A et al., J Org Chem, 79, 5861-5868, 2014. The content of deuterium can be determined, e.g., using mass spectrometry or NMR spectroscopy. Unless specifically indicated otherwise, it is preferred that the compound of formula (I) is not enriched in deuterium. Accordingly, the presence of naturally occurring hydrogen atoms or 1H hydrogen atoms in the compounds of formula (I) is preferred. The present invention also embraces compounds of formula (I), in which one or more atoms are replaced by a positron-emitting isotope of the corresponding atom, such as, e.g., 18F, 11C, 13N, 150,76Br, 77Br, 120l and / or 124l. Such compounds can be used as tracers, trackers or imaging probes in positron emission tomography (PET). The invention thus includes (I) compounds of formula (I), in which one or more fluorine atoms (or, e.g., all fluorine atoms) are replaced by 18F atoms, (II) compounds of formula (I), in which one or more carbon atoms (or, e.g., all carbon atoms) are replaced by 11C atoms, (ill) compounds 112 of formula (I), in which one or more nitrogen atoms (or, e.g., all nitrogen atoms) are replaced by 13N atoms, (iv) compounds of formula (I), in which one or more oxygen atoms (or, e.g., all oxygen atoms) are replaced by 15O atoms, (v) compounds of formula (I), in which one or more bromine atoms (or, e.g., all bromine atoms) are replaced by 76Br atoms, (vi) compounds of formula (I), in which one or more bromine atoms (or, e.g., all bromine atoms) are replaced by 77Br atoms, (vii) compounds of formula (I), in which one or more iodine atoms (or, e.g., all iodine atoms) are replaced by 120l atoms, and (viii) compounds of formula (I), in which one or more iodine atoms (or, e.g., all iodine atoms) are replaced by 124l atoms. In general, it is preferred that none of the atoms in the compounds of formula (I) are replaced by specific isotopes. The present invention further embraces the prodrugs of the compounds of formula (I). As preferably understood herein, the term “prodrug" of the compound of formula (I) refers to a derivative of the compounds of formula (I) that upon administration to a subject becomes metabolized to the said compound of formula (I). Said prodrugs of the compound of formula (I) may include modifications of -OH, -NH2, or -COOH group if present in the compound of formula (I), which preferably can be hydrolyzed to -OH, -NH2, or-COOH groups, respectively, e.g. upon administration to the subject. For example, as known to the skilled person, such prodrugs may preferably include for the compounds of formula (I) which comprise -OH moiety derivatives wherein said -OH moiety is turned into an -ORX moiety, wherein Rx preferably comprises a moiety selected from -CO-, -CH2-O-CO, -CH2-O-CO-O-, and -CH(CH3)-O-COO-, more preferably wherein Rx is selected from -CO-Ry, -CH2-O-CO-Ry, -CH2-O-CO-O-Ry, and -CH(CH3)-O-COO-Ry, wherein Ry is preferably carbocyclyl, heterocyclyl, C1-5 alkyl, -NH-(Ci-5 alkyl) or -S-(Ci-5 alkyl), wherein the said alkyl is optionally substituted with a group selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), and wherein the said carbocyclyl and heterocyclyl are each optionally substituted with a group selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(C 1-5 alkyl). Furthermore, for example, as known to the skilled person, such prodrugs may preferably include for the compounds of formula (I) which comprise -NH2 moiety derivatives wherein said -NH2 moiety is turned into -NHCOO-Ry moiety, wherein Ry is as defined hereinabove. Furthermore, for examples, as known to the skilled person, such prodrugs may preferably include for the compounds of formula (I) which comprise -COOH moiety derivatives wherein said -COOH group is turned into -COORy moiety, wherein Ry is as defined hereinabove. Further examples of groups that can be derivatized to yield prodrugs are known to the skilled person. Pharmaceutical compositions The compounds provided herein may be administered as compounds perse or may be formulated as medicaments. The medicaments / pharmaceutical compositions may optionally comprise one or more pharmaceutically acceptable excipients, such as carriers, diluents, fillers, disintegrants, lubricating agents, binders, colorants, pigments, stabilizers, preservatives, antioxidants, and / or solubility enhancers. The pharmaceutical compositions may comprise one or more solubility enhancers, such as, e.g., poly(ethylene glycol), including poly(ethylene glycol) having a molecular weight in the range of about 200 to about 5,000 Da (e.g., PEG 200, PEG 300, PEG 400, or PEG 600), ethylene glycol, propylene glycol, glycerol, a non-ionic surfactant, tyloxapol, polysorbate 80, macrogol-15-hydroxystearate (e.g., Kolliphor® HS 15, CAS 70142-34-6), a phospholipid, lecithin, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, distearoyl phosphatidylcholine, a cyclodextrin, a-cyclodextrin, p-cyclodextrin, y-cyclodextrin, hydroxyethyl-|3-cyclodextrin, hydroxypropyl-P-cyclodextrin, hydroxyethyl-y-cyclodextrin, hydroxypropyl-y-cyclodextrin, dihydroxypropyl-|3-cyclodextrin, sulfobutylether-p-cyclodextrin, sulfobutylether-y-cyclodextrin, glucosyl-a-cyclodextrin, glucosyl-p-cyclodextrin, diglucosyl-p-cyclodextrin, maltosyl-a-cyclodextrin, maltosyl-p-cyclodextrin, maltosyl-y-cyclodextrin, maltotriosyl-p-cyclodextrin, maltotriosyl-y-cyclodextrin, dimaltosyl-p-cyclodextrin, methyl-p-cyclodextrin, a carboxyalkyl thioether, hydroxypropyl methylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, a vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate, or any combination thereof. The pharmaceutical compositions may also comprise one or more preservatives, particularly one or more antimicrobial preservatives, such as, e.g., benzyl alcohol, chlorobutanol, 2-ethoxyethanol, m-cresol, chlorocresol (e.g., 2-chloro-3-methyl-phenol or 4-chloro-3-methyl-phenol), benzalkonium chloride, benzethonium chloride, benzoic acid (or a pharmaceutically acceptable salt thereof), sorbic acid (or a pharmaceutically acceptable salt thereof), chlorhexidine, thimerosal, or any combination thereof. The pharmaceutical compositions can be formulated by techniques known to the person skilled in the art, such as the techniques published in ‘‘Remington: The Science and Practice of Pharmacy”, Pharmaceutical Press, 22nd edition. The pharmaceutical compositions can be formulated as dosage forms for oral, parenteral, such as intramuscular, intravenous, subcutaneous, intradermal, intraarterial, intracardial, rectal, nasal, topical, aerosol or vaginal administration. Dosage forms for oral administration include coated and uncoated tablets, soft gelatin capsules, hard gelatin capsules, lozenges, troches, solutions, emulsions, suspensions, syrups, elixirs, powders and granules for reconstitution, dispersible powders and granules, medicated gums, chewing tablets and effervescent tablets. Dosage forms for parenteral administration include solutions, emulsions, suspensions, dispersions and powders and granules for reconstitution. Emulsions are a preferred dosage form for parenteral administration. Dosage 114 forms for rectal and vaginal administration include suppositories and ovula. Dosage forms for nasal administration can be administered via inhalation and insufflation, for example by a metered inhaler. Dosage forms for topical administration include creams, gels, ointments, salves, patches and transdermal delivery systems. The compounds of formula (I) or the above described pharmaceutical compositions comprising a compound of formula (I) may be administered to a subject by any convenient route of administration, whether systemically / peripherally or at the site of desired action, including but not limited to one or more of: oral (e.g., as a tablet, capsule, or as an ingestible solution), topical (e.g., transdermal, intranasal, ocular, buccal, and sublingual), parenteral (e.g., using injection techniques or infusion techniques, and including, for example, by injection, e.g., subcutaneous, intradermal, intramuscular, intravenous, intraarterial, intracardiac, intrathecal, intraspinal, intracapsular, subcapsular, intraorbital, intraperitoneal, intratracheal, subcuticular, intraarticular, subarachnoid, or intrasternal by, e.g., implant of a depot, for example, subcutaneously or intramuscularly), pulmonary (e.g., by inhalation or insufflation therapy using, e.g., an aerosol, e.g., through mouth or nose), gastrointestinal, intrauterine, intraocular, subcutaneous, ophthalmic (including intravitreal or intracameral), rectal, or vaginal administration. If said compounds or pharmaceutical compositions are administered parenterally, then examples of such administration include one or more of: intravenously, intraarterially, intraperitoneally, intrathecally, intraventricularly, intraurethrally, intrasternally, intracardially, intracranially, intramuscularly or subcutaneously administering the compounds or pharmaceutical compositions, and / or by using infusion techniques. For parenteral administration, the compounds are best used in the form of a sterile aqueous solution which may contain other substances, for example, enough salts or glucose to make the solution isotonic with blood. The aqueous solutions should be suitably buffered (preferably to a pH of from 3 to 9), if necessary. The preparation of suitable parenteral formulations under sterile conditions is readily accomplished by standard pharmaceutical techniques well known to those skilled in the art. Said compounds or pharmaceutical compositions can also be administered orally in the form of tablets, capsules, ovules, elixirs, solutions or suspensions, which may contain flavoring or coloring agents, for immediate-, delayed-, modified-, sustained-, pulsed- or controlled-release applications. The tablets may contain excipients such as microcrystalline cellulose, lactose, sodium citrate, calcium carbonate, dibasic calcium phosphate and glycine, disintegrants such as starch (preferably corn, potato or tapioca starch), sodium starch glycolate, croscarmellose sodium and certain complex silicates, and granulation binders such as polyvinylpyrrolidone, hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC), sucrose, gelatin and acacia. Additionally, lubricating agents such as magnesium stearate, stearic acid, glyceryl behenate and talc may be included. Solid compositions of a 115 similar type may also be employed as fillers in gelatin capsules. Preferred excipients in this regard include lactose, starch, a cellulose, or high molecular weight polyethylene glycols. For aqueous suspensions and / or elixirs, the agent may be combined with various sweetening or flavoring agents, coloring matter or dyes, with emulsifying and / or suspending agents and with diluents such as water, ethanol, propylene glycol and glycerin, and combinations thereof. For oral administration, the compounds or pharmaceutical compositions are preferably administered by oral ingestion, particularly by swallowing. The compounds or pharmaceutical compositions can thus be administered to pass through the mouth into the gastrointestinal tract, which can also be referred to as “oral-gastrointestinal” administration. Alternatively, said compounds or pharmaceutical compositions can be administered in the form of a suppository or pessary, or may be applied topically in the form of a gel, hydrogel, lotion, solution, cream, ointment or dusting powder. The compounds of the present invention may also be dermally or transdermally administered, for example, by the use of a skin patch. Said compounds or pharmaceutical compositions may also be administered by sustained release systems. Suitable examples of sustained-release compositions include semi-permeable polymer matrices in the form of shaped articles, e.g., films, or microcapsules. Sustained-release matrices include, e.g., polylactides, copolymers of L-glutamic acid and gamma-ethyl-L-glutamate, poly(2-hydroxyethyl methacrylate), ethylene vinyl acetate, or poly-D-(-)-3-hydroxybutyric acid. Sustained-release pharmaceutical compositions also include liposomally entrapped compounds. The present invention thus also relates to liposomes containing a compound of the invention. Said compounds or pharmaceutical compositions may also be administered by the pulmonary route, rectal routes, or the ocular route. For ophthalmic use, they can be formulated as micronized suspensions in isotonic, pH adjusted, sterile saline, or, preferably, as solutions in isotonic, pH adjusted, sterile saline, optionally in combination with a preservative such as a benzalkonium chloride. Alternatively, they may be formulated in an ointment such as petrolatum. It is also envisaged to prepare dry powder formulations of the compounds of formula (I) for pulmonary administration, particularly inhalation. Such dry powders may be prepared by spray drying under conditions which result in a substantially amorphous glassy or a substantially crystalline bioactive powder. Accordingly, dry powders of the compounds of the present invention can be made according to an emulsification / spray drying process. For topical application to the skin, said compounds or pharmaceutical compositions can be formulated as a suitable ointment containing the active compound suspended or dissolved in, for example, a mixture with one or more of the following: mineral oil, liquid petrolatum, white petrolatum, propylene 116 glycol, emulsifying wax and water. Alternatively, they can be formulated as a suitable lotion or cream, suspended or dissolved in, for example, a mixture of one or more of the following: mineral oil, sorbitan monostearate, a polyethylene glycol, liquid paraffin, polysorbate 60, cetyl esters wax, 2-octyldodecanol, benzyl alcohol and water. The present invention thus relates to the compounds or the pharmaceutical compositions provided herein, wherein the corresponding compound or pharmaceutical composition is to be administered by any one of: an oral route; topical route, including by transdermal, intranasal, ocular, buccal, or sublingual route; parenteral route using injection techniques or infusion techniques, including by subcutaneous, intradermal, intramuscular, intravenous, intraarterial, intracardiac, intrathecal, intraspinal, intracapsular, subcapsular, intraorbital, intraperitoneal, intratracheal, subcuticular, intraarticular, subarachnoid, intrasternal, intraventricular, intraurethral, or intracranial route; pulmonary route, including by inhalation or insufflation therapy; gastrointestinal route; intrauterine route; intraocular route; subcutaneous route; ophthalmic route, including by intravitreal, or intracameral route; rectal route; or vaginal route. Preferred routes of administration are oral administration or parenteral administration. For each of the compounds or pharmaceutical compositions provided herein, it is particularly preferred that the respective compound or pharmaceutical composition is to be administered orally (particularly by oral ingestion). Typically, a physician will determine the actual dosage which will be most suitable for an individual subject. The specific dose level and frequency of dosage for any particular individual subject may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the individual subject undergoing therapy. A proposed, yet non-limiting dose of the compounds according to the invention for oral administration to a human (of approximately 70 kg body weight) may be 0.05 to 2000 mg, preferably 0.1 mg to 1000 mg, of the active ingredient per unit dose. The unit dose may be administered, e.g., 1 to 3 times per day. The unit dose may also be administered 1 to 7 times per week, e.g., with not more than one administration per day. It will be appreciated that it may be necessary to make routine variations to the dosage depending on the age and weight of the patient / subject as well as the severity of the condition to be treated. The precise dose and also the route of administration will ultimately be at the discretion of the attendant physician or veterinarian. Therapeutic use In one embodiment, the present invention relates to the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition as defined herein for use in therapy. The present invention provides compounds that function as inhibitors of PARG. Thus, the present invention provides a method of inhibiting PARG enzyme activity in vitro or in vivo, said method comprising contacting a cell with an effective amount of the compound of formula (I), ora pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein. The present invention also provides a method of selectively inhibiting PARG enzyme activity over PARP1 or ARH3 enzyme activity in vitro or in vivo. The said method comprises the steps of contacting a cell with an effective amount of a compound, or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein. In a further embodiment, the present invention relates to the compound of formula (I), as disclosed herein, for use in a method of treating a disease or disorder in which PARG activity is implicated in a subject or patient in need of such treatment. Said method of treatment comprises administering to said subject / patient a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition as defined herein. In other words, in one embodiment the present invention relates to the compound of formula (I), as disclosed herein, for use in treating a disease or disorder in which PARG activity is implicated. In a further embodiment, the present invention relates to a method of inhibiting cell proliferation, in vitro or in vivo, said method comprising contacting a cell with an effective amount of the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein. Thus, the present invention relates to the compound of formula (I) or a pharmaceutically acceptable salt thereof for use in of inhibiting cell proliferation, in vitro or in vivo. Thus, in a further embodiment, the present invention relates to a method of treating a proliferative disorder in a subject or patient in need of such treatment. The said method of treating a proliferative disorder in a subject or patient in need thereof comprises administering to said subject / patient a therapeutically effective amount of the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition as defined herein. Preferably as disclosed herein, the proliferative disorder is cancer. Thus, the present invention relates to a method of treating cancer in a subject or patient in need thereof. The said method of treating cancer in a subject or patient in need thereof comprises administering to said subject / patient a therapeutically effective amount of the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition as defined herein. In a particular embodiment, the cancer is human cancer. In one embodiment, the present invention relates to the compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, for use in treating a proliferative disorder. Preferably as disclosed herein, the proliferative disorder is cancer. Therefore, the present invention relates to the compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof for use in treating cancer. In a particular embodiment, the cancer is human cancer. In a further embodiment, the present invention relates to the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein, for use in the manufacture of a medicament for the treatmentof a proliferative condition. In a preferred embodiment, the proliferative condition is cancer, more preferably a human cancer. Thus, preferably the present invention relates to the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein, for use in the manufacture of a medicament for the treatmentof cancer, preferably for the treatment of human cancer. In a further embodiment, the present invention relates to the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein, for use in the manufacture of a medicament for the inhibition of PARG enzyme activity. Preferably, the inhibition of PARG enzyme activity is selective inhibition of PARG enzyme activity over PARP1 or ARH3 enzyme activity. Thus, the present invention relates to the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein, for use in the manufacture of a medicament for the selective inhibition of PARG enzyme activity over PARP1 or ARH3 enzyme activity. The present invention further provides the compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined herein for use in the manufacture of a medicament for the treatment of a disease or disorder in which PARG activity is implicated, as defined herein. As understood herein, the term "proliferative disorder" are used interchangeably herein and pertain to an unwanted or uncontrolled cellular proliferation of excessive or abnormal cells which is undesired, such as, neoplastic or hyperplastic growth, whether in vitro or in vivo. Examples of proliferative conditions include, but are not limited to, pre-malignant and malignant cellular proliferation, including but not limited to, malignant neoplasms and tumours, cancers, leukemias, psoriasis, bone diseases, fibroproliferative disorders (e.g., of connective tissues), and atherosclerosis. Any type of cell may be treated, including but not limited to, lung, colon, breast, ovarian, prostate, liver, pancreas, brain, and skin. The anti-proliferative effects of the compound of formula (I) of the present invention have particular application in the treatment of human cancers (by virtue of their inhibition of PARG enzyme activity). The anti-cancer effect may arise through one or more mechanisms, including but not limited to, the regulation of cell proliferation, the inhibition of angiogenesis (the formation of new blood vessels), the inhibition of 119 metastasis (the spread of a tumour from its origin), the inhibition of invasion (the spread of tumour cells into neighbouring normal structures), or the promotion of apoptosis (programmed cell death). The antiproliferative treatment with the compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, as defined hereinbefore, may be applied as a sole therapy or may involve, in addition to the compound of the invention, conventional surgery or radiotherapy or chemotherapy. Such chemotherapy may include one or more of the following categories of anti-tumour agents:- (i) other antiproliferative / antineoplastic drugs and combinations thereof, as used in medical oncology, such as alkylating agents (for example cis-plat...

Claims

1. A compound of formula (I):R4(I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof, wherein:Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl, (Ci-2)haloalkyl -(C1-2 alkylene)-OH and -(C1-2 alkylene)-O-(Ci-2 alkyl);R2 and R3 are independently each (Ci-2)alkyl or (Ci-2)haloalkyl, or R2 and R3 together with the carbon atom to which they are attached form cyclopropyl;W is selected from -NHS(O)y-, -S(O)yNH-, -NHS(O)(NH)-, -NHS(O)(NCH3)-, -S(O)(NH)-NH-, -S(O)(NCH3)-NH-, wherein y is 1 or 2;Xi and Xsare independently selected from the group consisting of N, CH, C(Ci-2 alkyl), C-CI and C-F;X2 is N or C-Yc2-Rc2,wherein Yc2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, C2-5 alkynylene, cycloalkylene, cycloalkenylene, heterocycloalkylene and heterocycloalkenylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-s alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-s alkyl), NHCONH2, NHCONH-(C1-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5alkyl), and N(Ci-s alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Cis alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-s alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-5 alkyl)-, CO-, S-, -SO-, and SO2-, and further wherein said cycloalkylene, said cycloalkenylene, said heterocycloalkylene and said heterocycloalkenylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(A / -heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci^ alkyl)-CO-(C1-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-s alkyl)CONH2, N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)( / V-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)CONH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-(W-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-CO-(Ci-s alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, O(Ci-5 alkyl), SH, S(Cis alkyl), NH2, NH(Ci-s alkyl), and N(Ci-s alkyl)(Ci-5 alkyl), andwherein Rc2 is selected from hydrogen, halo, -OH, -NH2, -SH, -CN, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl,wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), 516-C0(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-C0-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(0)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), and -P(0)(0(Ci-5 alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -0(Ci-5 alkyl)-, -0(Ci-5 haloalkyl)-, C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), preferably selected from halogen, -CN, -OH, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-s alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), and -P(O)(O(Ci-s alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci^ alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl), andwherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-s alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci^ alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-( / V-517heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-C0-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(Ci^ alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(Ci^ alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(A / -heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-s alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -COO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-s 518alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(0)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(Ci^ alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(Ci^ alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(Ci^ alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-s alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(A / -heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 519alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl);X4 is N or C-Rc4,wherein Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), -N(Ci-6 alkyl)(Ci-6 alkyl), -CO(Ci-6 alkyl), C1-6 haloalkyl, -O(Ci-6 haloalkyl), -S(Ci-6 haloalkyl), -NH(Ci^ haloalkyl), -N(Ci-6 haloalkyl)2, -CO(Ci-6 haloalkyl), -(C0-3 alkylene)cycloalkyl, -0-(Co-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)cycloalkenyl, -0-(Co-3 alkylene)-cycloalkenyl, -CO-(Co-3 alkylene)-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -0-(Co-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-520heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -0-(Co-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)-aryl, -0-(Co-3 alkylene)-aryl, -C0-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-heteroaryl, -0-(Co-3 alkylene)-heteroaryl and -CO-(Co-3 alkylene)-heteroaryl,wherein said alkyl or said alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), Ci-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), andwherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-s alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-s alkyl), -(C1-5 alkylene)-CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5215 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-C0-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl);X5 is N or C-Rcs,wherein Res is selected from hydrogen, halo, C1-6 alkyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), -N(Ci-6 alkyl)(Ci-6 alkyl) and C1-6 haloalkyl;R4 is Yrs-Rrs,wherein Yrs is selected from a covalent bond, Cm alkylene, C24 alkenylene, and C24 alkynylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-s haloalkyl), -SO2(Ci-s haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), and -N(Ci-s haloalkyl)(Ci-s alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-s alkyl)-, CO-, -C00-, S-, -SO-, and S02-, andwherein Rrs is selected from Ci-i2 alkyl, Cm2 alkenyl, C2-i2 alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl,wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Cm alkyl), -NH(Ci-5 haloalkyl), -N(Cm alkyl)(Ci-5 alkyl), -N(Cm haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), and wherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl),.

2. The compound of claim 1, wherein Ri is selected from the group consisting of hydrogen, chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl.

3. The compound of claim 1 or 2, wherein Ri is selected from the group consisting of chloro, fluoro, cyano, formyl, (Ci-2)alkyl, (C2)alkenyl, (C2)alkynyl and (Ci-2)haloalkyl.

4. The compound of any one of claims 1 to 3, wherein Ri is selected from the group consisting of cyano, (Ci-2)alkyl, and (Ci-2)haloalkyl.

5. The compound of any one of claims 1 to 4, wherein Ri is selected from the group consisting of cyano, methyl and fluoromethyl.

6. The compound of any one of claims 1 to 5, wherein Ri is cyano.

7. The compound of any one of claims 1 to 5, wherein Ri is methyl.

8. The compound of any one of claims 1 to 5, wherein Ri is fluoromethyl.

9. The compound of any one of claims 1 to 9, wherein R2 and R3 together with the carbon atom towhich they are attached form cyclopropyl.

10. The compound of any one of claims 1 to 9, wherein W is -NHS(O)2-, preferably wherein the left side of W as defined herein is attached to the carbon atom that carries Ri, R2 and R3, and the right side of W as defined herein is attached to the ring system shown in formula (I).

11. The compound of any one of claims 1 to 10, wherein Xi and X3 are independently selected from the group consisting of N, CH and CF.

12. The compound of any one of claims 1 to 11, wherein Xi and X3 are each CH.

13. The compound of any one of claims 1 to 12, wherein Yc2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, C2-5 alkynylene, cycloalkylene and heterocycloalkylene wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), N(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-5 alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-5 alkyl)CONH2, N(Ci^ alkyl)CONH-(Ci^ alkyl), and N(Ci^ alkyl)CON(Ci-s alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Cis alkyl), NH2, NH(Ci^ alkyl), and N(Ci-5 alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-5 alkyl)-, CO-, S-, -SO-, and SO2-, and further wherein said cycloalkylene and said heterocycloalkylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, C1-5 alkyl, C1-5 haloalkyl, 0(Ci-5 alkyl), -0(Ci-5 haloalkyl), SH, S(Ci5 alkyl), -S(Ci-5 haloalkyl), NH2, NH(Ci-5 alkyl), -NH(Ci^ haloalkyl), N(Ci-s alkyl)(Ci-5 alkyl), N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -C0(Ci-5 alkyl), CONH2, CONH(Ci-5 alkyl), CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), NHCO-(Ci-5 alkyl), N(Ci-s alkyl)-CO-(Ci-5 alkyl), NHCONH2, NHCONH-(Ci-5 alkyl), NHCON(Ci-5 alkyl)(Ci-5 alkyl), N(Ci-s alkyl)CONH2, N(Ci-5 alkyl)C0NH-(Ci-5 alkyl), and N(Ci-5 alkyl)CON(Ci-s alkyl)(Ci-s alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)OH, -(C1-5 alkylene)O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)SH, -(C1-5 alkylene)S(Ci5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)NH2, -(C1-5 alkylene)NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)(W-heterocycloalkyl), -(C1-5 alkylene)N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)C0NH2, -(C1-5 alkylene)CONH(Ci-5 alkyl), -(C1-5 alkylene)CON(Ci-s alkyl)(Ci-5 alkyl), -(C1-5 alkylene)CO-(W-heterocycloalkyl), -(C1-5 alkylene)NHCO-(Ci-5 alkyl), -(C1-5 alkylene)N(Ci-5 alkyl)-C0-(Ci-5 alkyl), -(C1-5 alkylene)NHCONH2, -(C1-5 alkylene)NHCONH-(Ci-s alkyl), -(C1-5 alkylene)NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene) N(Ci -5 alkyl)CONH2, -(C1-5 alkylene)N(Ci-s al ky l)CONH-(Ci-s alkyl), and -(C1-5 alkylene)N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, CN, OH, C1-5 alkyl, 0(Ci-5 alkyl), SH, S(Cis alkyl), NH2, NH(Ci-s alkyl), and N(Ci-5 alkyl)(Ci-5 alkyl).14.The compound of any one of claims 1 to 13, wherein X2 is C-Yc2-Rc2, wherein -Yc2-Rc2 is selected from -O-C1-12 alkyl, -NH-C1-12 alkyl, -N(Ci-5 alkyl)-Ci-i2 alkyl, -O-C2-12 alkenyl, -NH-C2-12 alkenyl, -N(Ci-5 alkyl)-C2-i2 alkenyl, -O-C2-12 alkynyl, -NH-C2-12 alkynyl, -N(Ci-5 alkyl)-C2-i2 alkynyl, (C0-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-CO-cycloalkyl, -CONH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-CONH-cycloalkyl, -NHCO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-NHCO-cycloalkyl, -NH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-NH-cycloalkyl, -0-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, (C0-3 alkylene)-cycloalkenyl, -CO-(Co-3 alkylene)cycloalkenyl, (C0-3 alkylene)-CO-cycloalkenyl, -CONH-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-CONH-cycloalkenyl, -NHCO-(Co-3 alkylene)cycloalkenyl, (C0-3 alkylene)-NHCO-cycloalkenyl, -NH-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-NH-cycloalkenyl, -0-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-O-cycloalkenyl, -S02-(Co-3 alkylene)cycloalkenyl, -(C0-3 alkylene)-SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, -SO2-cycloalkenyl, -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(Co-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(Co-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl,-(C0-3 alkylene)-O-heterocycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CO-heterocycloalkenyl, -CONH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NHCO-heterocycloalkenyl, -NH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NH-heterocycloalkenyl, -0-(Co-3 alkylene) heterocycloalkenyl, -(C0-3 alkylene)-O-heterocycloalkenyl, -S02-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, (C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-ary I, -CO-ary I, -SO2-525aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, (C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -O-C1-12 alkyl, -NH-C1-12 alkyl, -N(Ci-5 alkyl)-Ci-i2 alkyl, -O-C2-12 alkenyl, -NH-C2-12 alkenyl, -N(Ci-5 alkyl)-C2-i2 alkenyl, -O-C2-12 alkynyl, -NH-C2-12 alkynyl, -N(Ci-5 alkyl)-C2-i2 alkynyl, (C0-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-CO-cycloalkyl, -CONH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-CONH-cycloalkyl, -NHCO-(Co-3 alkylene)cycloalkyl, (C0-3 alkylene)-NHCO-cycloalkyl, -NH-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-NH-cycloalkyl, -0-(Co-3 alkylene)cycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)cycloalkyl, -(C0-3alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, alkylene)heterocycloalkyl,       -(C0-3alkylene)heterocycloalkyl, -(C0-3 alkylene)heterocycloalkyl,       -(C0-3-(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-CO-heterocycloalkyl,       -CONH-(Co-3alkylene)-CONH-heterocycloalkyl,      -NHCO-(Co-3alkylene)-NHCO-heterocycloalkyl,       -NH-(Co-3alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, (C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, (C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 526haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(C1-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -S(O)(Ci^ alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), and -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl) and wherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-s alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5   alkyl)CON(Ci-5 alkyl)(Ci-5alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-s alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-( / V-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-( / V-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(Ci-5275 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl)15. The compound of any one of claims 1 to 14, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, (C0-3 alkylene)-O-cycloalkyl, (C0-3 alkylene)-O-heterocycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -CO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CO-heterocycloalkenyl, -CONH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-CONH-heterocycloalkenyl, -NHCO-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NHCO-heterocycloalkenyl, -NH-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-NH-heterocycloalkenyl, -0-(Co-3 alkylene) heterocycloalkenyl, (C0-3 alkylene)-O-heterocycloalkenyl, -S02-(Co-3 alkylene)heterocycloalkenyl, -(C0-3 alkylene)-SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 528alkylene)heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3alkylene)heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene) heterocycloalkyl, (C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)heterocycloalkyl, -(C0-3 alkylene)-S02-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)aryl, -CO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-s alkyl), -(W-heterocycloalkyl), -CO(Ci-s alkyl), -C0(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-s alkyl), -COO(Ci-s haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-s alkyl)(Ci-5 alkyl), -C0-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-s alkyl)CONH-(Ci-s alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-5 alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)COO-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(O)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 529alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl).

16. The compound of any one of claims 1 to 15, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -0-heterocycloalkenyl, -CO-heterocycloalkenyl, -SO2-heterocycloalkenyl, -(C0-3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -SO2-aryl, -(C0-3 alkylene)heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -S02-heterocycloalkyl, -(C0-3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -0-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(0)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -C0(Ci-5 alkyl), -C0(Ci-5 haloalkyl), -CO-cycloalkyl, -C00(Ci-5 alkyl), -C00(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -C0N(Ci-5 alkyl)(Ci-5 alkyl), -C0-(W-heterocycloalkyl), -NHC0-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 530alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-s alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)C00-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(0)(0(Ci-5 alkyl))(0(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N (C1-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-s haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(Ci^ alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(Ci^ alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-s alkyl)COO-(Ci-5 alkyl).

17. The compound of any one of claims 1 to 16, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-heterocycloalkenyl, -(C0-3 alkylene)aryl, and -(C0-3 alkylene)heteroaryl, preferably -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)aryl, and -(C0-3 alkylene)heteroaryl, wherein said heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CO(Ci-5 haloalkyl), -CO-cycloalkyl, -COO(Ci-5 alkyl), -COO(Ci-5 haloalkyl), -COO-cycloalkyl, -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 531alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)C0N(Ci-5 alkyl)(Ci-5 alkyl), -OCONH2, -OCONH-(Ci-5 alkyl), -OCON(Ci-5 alkyl)(Ci-s alkyl), -NHCOO(Ci-5 alkyl), -N(Ci-5 alkyl)C00-(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-s alkyl), -P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-s alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-0(Ci-5 alkyl), -(C1-5 alkylene)-0(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-S(0)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)2(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(0)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(0(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N (C1-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 haloalkyl), -(C1-5 alkylene)-CO-cycloalkyl, -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(Ci^ alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(Ci^ alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), -(C1-5 alkylene)-OCONH2, -(C1-5 alkylene)-OCONH-(Ci-5 alkyl), -(C1-5 alkylene)-OCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NHCOO(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)COO-(Ci-5 alkyl).

18. The compound of any one of claims 1 to 12,wherein Yc2 is selected from a covalent bond, C1-5 alkylene, C2-5 alkenylene, and C2-5 alkynylene, wherein said alkylene, said alkenylene and said alkynylene are each optionally substituted with one or more groups independently selected from halogen, CN, OH, O(Ci-5 alkyl), SH, S(Ci5 alkyl), NH2, NH(Ci-5 alkyl), and N(Ci-5 alkyl)(Ci-5 alkyl), and further wherein one or more -CH2- units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from -0-, NH-, N(Ci-5 alkyl)-, CO-, S-, -SO-, and S02-, andwherein Rc2 is selected from hydrogen, halo, -OH, -NH2, -SH, -CN, Ci-i2 alkyl, C2-i2 alkenyl, C2-i2 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl,wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -0(Ci-5 alkyl), -0(Ci-5 haloalkyl), Ci-5325 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci^ alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), -S(O)(Ci-5 alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), and -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), andwherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(O)(Ci-s alkyl), -S(O)2(Ci-5 alkyl), -S(O)(NH)(Ci-5 alkyl), -S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -N=S(O)(Ci-5 alkyl)(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -(N-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-(W-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-s alkyl)-CO-(Ci-s alkyl), -NHCONH2, -NHCONH-(Ci-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-s alkyl), -P(O)(Ci-5 alkyl)(Ci-5 alkyl), -P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-CN, -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 al kylene)-S(O)(Ci-5 alkyl), -(C1-5 al ky lene)-S(O)2(Ci -5 alkyl), -(C1-5 alkylene)-S(O)(NH)(Ci-5 alkyl), -(C1-5 alkylene)-S(O)(N(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(O(Ci-5 alkyl)), -(C1-5 alkylene)-P(O)(O(Ci-5 alkyl))(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-s haloalkyl), -(Ci-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 533alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-C0N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -0(Ci-5 haloalkyl), -(C1-5 alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-NH2, -(C1-5 alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

19. The compound of claim 18, wherein X2 is C-Yc2-Rc2, wherein -Yc2-Rc2 is selected from -O-Ci-i2 alkyl, -NH-Ci-i2 alkyl, -N(Ci-5 alkyl)-Ci-i2 alkyl, -O-C2-12 alkenyl, -NH-C2-12 alkenyl, -N(Ci-s alkyl)-C2-12 alkenyl, -O-C2-i2 alkynyl, -NH-C2-i2 alkynyl, -N(Ci-s alkyl)-C2-i2 alkynyl, -(C0-3 alkylene)-cycloalkyl, -CO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-CO-cycloalkyl, -CONH-(Co-3 alkylene)-cycloalkyl, (C0-3 alkylene)-CONH-cycloalkyl, -NHCO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-NHCO-cycloalkyl, -NH-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-NH-cycloalkyl, -0-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)-534heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-aryl, -CO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-SO2-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)-heteroaryl, -CO-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl) and wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

20. The compound of claim 18 or 19, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-CO-heterocycloalkyl, -CONH-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-NH-heterocycloalkyl, -0-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-O-cycloalkyl, -S02-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)-aryl, -CO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-CO-aryl, -CONH-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-CONH-aryl, -NHCO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-NHCO-aryl, -NH-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-NH-aryl, -0-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-O-aryl, -S02-(Co-3 alkylene)-aryl, -(C0-3 535alkylene)-S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)-heteroaryl, -CO-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-CO-heteroaryl, -CONH-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-CONH-heteroaryl, -NHCO-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-NHCO-heteroaryl, -NH-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-NH-heteroaryl, -0-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-O-heteroaryl, -S02-(Co-3 alkylene)-heteroaryl, -(C0-3 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, Ci-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

21. The compound of any one of claims 18 to 20, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -0-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-3 alkylene)aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-3 alkylene)-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl and -SO2-heteroaryl, wherein said heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

22. The compound of any one of claims 18 to 21, wherein -Yc2-Rc2 is selected from -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl, and -(C0-3 alkylene)-heteroaryl, wherein said heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

23. The compound of any one of claims 18 to 22, wherein -Yc2-Rc2 is selected from heterocycloalkyl, aryl, and heteroaryl, preferably heterocycloalkyl and heteroaryl, more preferably heterocycloalkyl, wherein said heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups 536independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 haloalkyl), -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

24. The compound of any one of claims 18 to 23, wherein -Yc2-Rc2 is optionally substituted aryl, preferably -Yc2-Rc2 is phenyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl),or wherein -Yc2-Rc2 is an optionally substituted heteroaryl, preferably wherein -Yc2-Rc2 is imidazolyl, pyridazinyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, or indazolyl, wherein heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl),or wherein -Yc2-Rc2 is optionally substituted heterocycloalkyl, preferably wherein -Yc2-Rc2 is morpholinyl, 1,1-dioxothiomorpholinyl, azetinyl, pyrrolidinyl, piperidinyl, 6-oxo-1,6-dihydropyridinyl, or piperazinyl, wherein heterocycloalkyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci^ haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

25. The compound of any one of claims 18 to 24, wherein -Yc2-Rc2 is piperazinyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably wherein -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) optionally substituted (preferably N-substituted) with CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), more preferably wherein -Yc2-Rc2 is piperazinyl (preferably N-piperazinyl) substituted (preferably N-substituted, preferably at a 537different N-atom than that attached to the ring system as shown in formula (I)), with -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably with -CON(CH3)2.

26. The compound of any one of claims 1 to 25, wherein X4 is C-Rc4, wherein Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O(Ci-6 alkyl), -S(Ci-6 alkyl), -NH(Ci-6 alkyl), -N(Ci-6 alkyl)(Ci-6 alkyl), -CO(Ci-6 alkyl), C1-6 haloalkyl, -O(Ci-6 haloalkyl), -S(Ci-6 haloalkyl), -NH(Ci-6 haloalkyl), -N(Ci-6 haloalkyl, -CO(Ci-6 haloalkyl), -(C0-3 alkylene)cycloalkyl, -0-(Co-3 al ky lene)-cycloalkyl, -CO-(Co-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -0-(Co-3 alkylene)-heterocycloalkyl, -CO-(Co-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl, -0-(Co-3 alkylene)-aryl, -CO-(Co-3 alkylene)-aryl, -(C0-3 alkylene)-heteroaryl, -0-(Co-3 alkylene)-heteroaryl and -CO-(Co-3 alkylene)-heteroaryl;wherein said alkyl or said alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), C1-5 haloalkyl, -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -( / V-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -CO-( / V-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(C1-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-s alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-s alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), and wherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -(W-heterocycloalkyl), -CO(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), -CON(Ci-5 alkyl)(Ci-5 alkyl), -C0-(N-heterocycloalkyl), -NHCO-(Ci-5 alkyl), -N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -NHCONH2, -NHCONH-(C1-5 alkyl), -NHCON(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 alkyl)CONH2, -N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5alkyl), -(C1-5alkylene)-CN, -(C1-5alkylene)-OH, -(C1-5 alkylene)-O(Ci-5 alkyl), -(C1-5 alkylene)-O(Ci-5 haloalkyl), -(C1-5 alkylene)-SH, -(C1-5 alkylene)-S(Ci-5 alkyl), -(C1-5 alkylene)-S(Ci-5 haloalkyl), -(C1-5 alkylene)-NH2, -(C1-5 538alkylene)-NH(Ci-5 alkyl), -(C1-5 alkylene)-NH(Ci-5 haloalkyl), -(C1-5 alkylene)-N (C1-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)(Ci-5 haloalkyl), -(C1-5 alkylene)-(W-heterocycloalkyl), -(C1-5 alkylene)-N(Ci-5 haloalkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO(Ci-5 alkyl), -(C1-5 alkylene)-CONH2, -(C1-5 alkylene)-CONH(Ci-5 alkyl), -(C1-5 alkylene)-CON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-CO-(W-heterocycloalkyl), -(C1-5 alkylene)-NHCO-(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)-CO-(Ci-5 alkyl), -(C1-5 alkylene)-NHCONH2, -(C1-5 alkylene)-NHCONH-(Ci-5 alkyl), -(C1-5 alkylene)-NHCON(Ci-5 alkyl)(Ci-5 alkyl), -(C1-5 alkylene)-N(Ci-5 alkyl)CONH2, -(C1-5 alkylene)-N(Ci-5 alkyl)CONH-(Ci-5 alkyl), and -(C1-5 alkylene)-N(Ci-5 alkyl)CON(Ci-5 alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

27. The compound of any one of claims 1 to 26, wherein X4 is C-Rc4, wherein Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O-C1-6 alkyl, -S-C1-6 alkyl, -NH-C1-6 alkyl, C1-6 haloalkyl, -(C0-3 alkylene)-cycloalkyl, -(C0-3 alkylene)-heterocycloalkyl, -(C0-3 alkylene)-aryl and -(C0-3 alkylene)-heteroaryl, wherein said alkyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -O(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), and wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 haloalkyl), -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-s haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

28. The compound of claim 27, wherein Rc4 is selected from hydrogen, halo, C1-6 alkyl, C2-6 alkynyl, -O-C1-6 alkyl, -S-C1-6 alkyl, -NH-C1-6 alkyl, and C1-6 haloalkyl, preferably wherein Rc4 is selected from hydrogen, halo, Ci-2 alkyl, and C2-3 alkynyl, more preferably wherein Rc4 is selected from hydrogen, halo, and Ci-2 alkyl, even more preferably wherein Rc4 is hydrogen or halo.

29. The compound of any one of claims 1 to 28, wherein Xs is C-Rcs, wherein Res is selected from hydrogen, halo, C1-3 alkyl, -O-C1-3 alkyl, -S-C1-3 alkyl, -NH-C1-3 alkyl, and C1-3 haloalkyl, preferably, wherein Res is selected from hydrogen, halo, C1-3 alkyl, and C1-3 haloalkyl.

30. The compound of any one of claims 1 to 29, wherein Rrs is selected from C1-12 alkyl, C1-12 alkenyl, C2-12 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl,wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected   from halogen, -CN,   -OH,   -O(Ci-s   alkyl), -O(Ci-shaloalkyl), -SH, -S(Ci-5  alkyl),  -S(Ci-5 haloalkyl),  -NH2,  -NH(Ci-s  alkyl), -NH(Ci-shaloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-5 alkyl)(Ci-s alkyl), and wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-s alkyl), -SO(Ci-5 alkyl), -SO2(Ci-s alkyl), -S(Ci-s haloalkyl), -SO(Ci-s haloalkyl), -SO2(Ci-s haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-s alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-s alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-s alkyl), -NH(Ci-s haloalkyl), -N(Ci-s alkyl)(Ci-s alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-s alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

31. The compound of any one of claims 1 to 29, wherein R4 is selected from -(C0-2 alkylene)-cycloalkyI, -CO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CO-cycloalkyl, -CONH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CONH-cycloalkyl, -NHCO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NHCO-cycloalkyl, -NH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NH-cycloalkyl, -0-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-O-cycloalkyl, S02-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, SO2-cycloalkyl, -(C0-2 alkylene)-cycloalkenyl, -CO-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-CO-cycloalkenyl, -CONH-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-CONH-cycloalkenyl, -NHCO-(C0-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-NHCO-cycloalkenyl, -NH-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-NH-cycloalkenyl, -0-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)-O-cycloalkenyl, S02-(Co-2 alkylene)-cycloalkenyl, -(C0-2 alkylene)SO2-cycloalkenyl, -CONH-cycloalkenyl, -NHCO-cycloalkenyl, -NH-cycloalkenyl, -O-cycloalkenyl, -CO-cycloalkenyl, SO2-cycloalkenyl, -(C0-2 540alkylene)-heterocycloalkyl, -CO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CO-heterocycloalkyl, -CONH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CONH-heterocycloalkyl,-NHCO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-2alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NH-heterocycloalkyl, -0-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-O-heterocycloalkyl, S02-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, SO2-heterocycloalkyl, -(C0-2 alkylene)-heterocycloalkenyl, -CO-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-CO- heterocycloalkenyl, -CONH-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-CONH- heterocycloalkenyl, -NHCO-(Co-2 alkylene)-heterocycloalkenyl, -(Co-2 alkylene)-NHCO- heterocycloalkenyl, -NH-(Co-2 alkylene)-heterocycloalkenyl, -(Co-2 alkylene)-NH-heterocycloalkenyl, -0-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)-O-heterocycloalkenyl,S02-(Co-2 alkylene)-heterocycloalkenyl, -(C0-2 alkylene)SO2-heterocycloalkenyl, -CONH-heterocycloalkenyl, -NHCO-heterocycloalkenyl, -NH-heterocycloalkenyl, -O-heterocycloalkenyl, -CO-heterocycloalkenyl, SO2-heterocycloalkenyl, -(C0-2 alkylene)-aryl, -CO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NH-aryl, -0-(C0-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-O-heteroaryl, S02-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and SO2-heteroaryl, wherein said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -C1-5 alkyl, -C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -SO(Ci-5 alkyl), -SO2(Ci-5 alkyl), -S(Ci-5 haloalkyl), -SO(Ci-5 haloalkyl), -SO2(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-s alkyl)(Ci-5 alkyl), preferably selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-s haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

32. The compound of any one of claims 1 to 31, wherein R4 is selected from -(C0-2 alkylene)-cycloalkyI, -CO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CO-cycloalkyl, -CONH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-CONH-cycloalkyl, -NHCO-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NHCO-cycloalkyl, -NH-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-NH-cycloalkyl, -0-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-O-cycloalkyl, -S02-(Co-2 alkylene)-cycloalkyl, -(C0-2 alkylene)-SO2-cycloalkyl, -CONH-cycloalkyl, -NHCO-cycloalkyl, -NH-cycloalkyl, -O-cycloalkyl, -CO-cycloalkyl, -SO2-cycloalkyl, -(C0-2 alkylene)-heterocycloalkyl, -CO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CO-heterocycloalkyl, -CONH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-CONH-heterocycloalkyl, -NHCO-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NHCO-heterocycloalkyl, -NH-(Co-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-NH-heterocycloalkyl, -0-(C0-2 alkylene)-heterocycloalkyl, -(C0-2 alkylene)-O-heterocycloalkyl, -S02-(Co-2 alkylene)-heterocycloalkyl,  -(C0-2 alkylene)-SO2-heterocycloalkyl, -CONH-heterocycloalkyl, -NHCO-heterocycloalkyl, -NH-heterocycloalkyl, -O-heterocycloalkyl, -CO-heterocycloalkyl, -SO2-heterocycloalkyl, -(C0-2 alkylene)-aryl, -CO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(C0-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NH-aryl, -0-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, -S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)heteroaryl, -(C0-2 alkylene)-O-heteroaryl, -S02-(Co-2 alkylene)heteroaryl, -(C0-2 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and -SO2-heteroaryl, wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

33. The compound of any one of claims 1 to 32, wherein R4 is selected from -(C0-2 alkylene)-aryl, -CO-(C0-2 alkylene)-aryl, -(C0-2 alkylene)-CO-aryl, -CONH-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-CONH-aryl, -NHCO-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-NHCO-aryl, -NH-(Co-2 alkylene)-aryl, -(C0-2 542alkylene)-NH-aryl, -0-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-O-aryl, -S02-(Co-2 alkylene)-aryl, -(C0-2 alkylene)-S02-aryl, -CONH-aryl, -NHCO-aryl, -NH-aryl, -O-aryl, -CO-aryl, -S02-aryl, -(C0-2 alkylene)-heteroaryl, -CO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CO-heteroaryl, -CONH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-CONH-heteroaryl, -NHCO-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NHCO-heteroaryl, -NH-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-NH-heteroaryl, -0-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-O-heteroaryl, -S02-(Co-2 alkylene)-heteroaryl, -(C0-2 alkylene)-SO2-heteroaryl, -CONH-heteroaryl, -NHCO-heteroaryl, -NH-heteroaryl, -O-heteroaryl, -CO-heteroaryl, and -SO2-heteroaryl, wherein said aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci^ alkyl).

34. The compound of any one of claims 1 to 32, wherein R4 is selected from C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, preferably wherein R4 is selected from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, more preferably wherein R4 is selected from aryl, and heteroaryl, even more preferably wherein R4 is heteroaryl, wherein said alkyl, alkenyl, or alkynyl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), and wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-s haloalkyl)(Ci-s alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl).

35. The compound of claim 34, wherein R4 is a five membered heteroaryl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -O(Ci-5 haloalkyl), -SH, -S(Ci-5 alkyl), -S(Ci-5 haloalkyl), -NH2, -NH(Ci-5 alkyl), -NH(Ci-5 haloalkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -N(Ci-5 haloalkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably wherein the five membered heteroaryl is selected from imidazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4543triazolyl, thiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, or 1,3,4-thiadiazolyl, preferably wherein the five membered heteroaryl is 1,2,4-thiadiazolyl, optionally substituted with one or more groups independently selected from halogen, -CN, -OH, C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -SH, -S(Ci-5 alkyl), -NH2, -NH(Ci-5 alkyl), -N(Ci-5 alkyl)(Ci-5 alkyl), -CONH2, -CONH(Ci-5 alkyl), and -CON(Ci-5 alkyl)(Ci-5 alkyl), preferably optionally substituted with C1-5 alkyl, C1-5 haloalkyl, -O(Ci-5 alkyl), -SH, -S(Ci-5 alkyl), more preferably optionally substituted with Ci-5 alkyl, C1-5 haloalkyl, even more preferably optionally substituted with C1-5 haloalkyl, preferably selected from -CH2F, -CHF2 and CF3, most preferably optionally substituted with -CHF2.

37. A pharmaceutical composition comprising the compound of any one of claims 1 to 36 or a pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutically acceptable carrier.

38. The compound of any one of claims 1 to 36 or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a pharmaceutical composition of claim 37, for use in therapy.

39. The compound for use or the pharmaceutical composition for use of claim 38, for use in a method of treating a disease or disorder in which PARG activity is implicated.

40. The compound for use or the pharmaceutical composition for use of claim 38, for use in a method of treating a proliferative disorder, preferably wherein the proliferative disorder is cancer, preferably a human cancer.