E3 ubiquitin ligase ligand compound, protein degrader developed based thereon and their applications

Abstract

The present disclosure relates to compounds of formula (I) and formula (II), or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs or polymorphs of said compounds, and the uses of same. The present disclosure also relates to pharmaceutical compositions containing, as active ingredients, the compounds of formula (I) and formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs or polymorphs of said compounds, and the uses of same.

Description

Technical Field

[0001] The present disclosure relates to cereblon (CRBN) E3 ubiquitin ligase ligand compounds of Formula (I), protein degrader compounds of Formula (II) comprising the same, and their applications. The CRBN E3 ubiquitin ligase ligand compounds can effectively treat or prevent cereblon protein mediated diseases or disorders. The protein degrader compounds of Formula (II) can effectively treat or prevent diseases or disorders associated with the proteins degraded. Background

[0002] Bifunctional proteolysis-targeting drugs consist of three moieties, one end of which is a ligand warhead that can bind to a specific target protein, and the other end is a small molecule ligand of E3 ubiquitin ligase, both of which are connected together through linkers of different lengths and categories located in the middle. The bifunctional proteolysis-targeting small molecules can utilize the binding effects of the ligands at both ends to simultaneously bind to a specific target protein and E3 ubiquitin ligase, thereby recruiting E3 ubiquitin ligase to the vicinity of the specific target protein and enabling E3 ubiquitin ligase to ubiquitinate the target protein. The polyubiquitinated target protein will be recognized and degraded by proteasomes in the body. The biggest difference between the bifunctional proteolysis-targeting drugs and traditional small molecule-based inhibitor drugs is that the former mobilize the entire cell as a drug effector unit. This drug action mode only requires small molecule drugs to briefly bind to the target protein and tag it for degradation. Therefore, a low drug dose can meet the requirements, greatly reducing the risk of off-target effects, and potentially eliminating tumor progression caused by abnormal expression of driver genes and drug resistance caused by acquired mutations in driver genes.

[0003] The E3 ubiquitin ligases involved in the design of proteolysis-targeting drugs include over 500 different proteins, each with a distinct cellular expression profile, and can be classified into multiple categories based on the structural elements related to their E3 functional activity. Currently, only a few ligases have been successfully applied in preclinical degraders research. Among them, Cereblon (CRBN) E3 ubiquitin ligase is one of the most widely used E3 ubiquitin ligases. The known ligands for CRBN-type E3 ubiquitin ligase (CRBN ligands) include thalidomide and its analogs pomalidomide and lenalidomide, all ofwhich possess a phthalimide backbone. CRBN-type E3 ubiquitin ligase ligands can also act as molecular glues to induce the degradation of specific proteins. Cereblon (CRBN) forms a functional E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cullin 4A, where CRBN serves as the substrate receptor. Molecular glue degraders like thalidomide bind to CRBN, inducing it to recognize new substrate proteins. The binding leads to the ubiquitination of these proteins, followed by their recognition and degradation by proteasomes.

[0004] CRBN ligands have been widely used in protein degradation, and a series of small molecules protein degraders based on CRBN ligands, which utilize the function of the CRBN E3 ubiquitin ligase complex, have gradually been developed. Since CRBN ligands can serve not only as molecular glue degraders to induce the degradation of different substrate proteins but also as a component of bifunctional proteolysis-targeting drugs to achieve effective degradation of specific pathogenic proteins, and given the unavoidable side effects and drug resistance issues associated with various existing domides compounds, such as thalidomide, it is of great significance to design novel and optimized E3 ubiquitin ligase ligands and study their binding ability to CRBN and evaluate their biological activity. Furthermore, these E3 ubiquitin ligase ligands can potentially be applied in bifunctional proteolysis-targeting small molecules.

[0005] Therefore, there is an urgent need for a series of novel CRBN E3 ubiquitin ligase ligands that can serve as effective molecular glue degraders and can also be further used to synthesize corresponding bifunctional proteolysis-targeting degraders for the treatment and / or prevention of diseases or conditions mediated or associated with the proteins degraded. Summary of Invention

[0006] In view of the above, the objectives of the present disclosure are to provide novel CRBN E3 ubiquitin ligase ligands, protein degrader molecules designed based on the novel CRBN E3 ubiquitin ligase ligands and various target protein ligands, as well as their applications and usage methods. The advantages of the compounds of the present disclosure lie in their ability to exhibit a wide range of pharmacological activities through the degradation / inhibition of diverse types or families of pathogenic proteins.

[0007] To achieve the above objectives and other related goals, in one aspect, the present disclosure provides novel CRBN E3 ubiquitin ligase ligands that can themselves act as molecular glues binding to CRBN E3 ligase, and subsequently induce the degradation of CRBN substrate proteins, including but not limited to GSPT1, IKZF1, IKZF2, IKZF3 (Aiolos), and IKZF4 proteins.

[0008] In some embodiments, the novel CRBN E3 ubiquitin ligase ligands of the present disclosure can be compounds of Formula (I): n(Rb) p_ R3R2r o' Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein A represents CO, CEE or CD2; Ri, R2, R3 and R4 are the same or different and independently represent e.g., hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl; (Ra)m indicates that benzene ring is substituted with m Ra substituents, with each Ra being the same or different and independently representing the structure of the following formula: wherein R represents chlorine, bromine, iodine, hydroxy, leaving group, NR?Rs or a group W1, wherein R7 and Rs are the same or different and independently represent hydrogen, C1-6 alkyl, C2-6 alkynyl-Ci-6 alkylene, C2-6 alkenyl-Ci-6 alkylene, optionally substituted 4- to 15membered nitrogen-containing heterocyclyl, or R2a-Rla-, where Rla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R2a represents halogen, amino, hydroxy, carboxyl, C2-6 alkynyl, C2-6 alkenyl or a leaving group; and W1 represents the structure of the following formula: wherein ring W2 represents optionally substituted nitrogen-containing heterocyclyl, each ring W3 is the same or different and independently represents optionally substituted nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, and ring W4 represents optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; Rs and Re are the same or different and independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Ra; wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, S(0), S(0)2, S(O)2NH, NHS(O)2, 0C(0), C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; or R and Rs, together with the carbon atom to which they are connected, form carbonyl group, Re represents hydrogen, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, S(0), S(0)2, S(O)2NH, NHS(O)2, 0C(0), C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; (Rb)n indicates that the benzene ring is substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl; and m represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4; wherein when R and Rs together with the carbon atom to which they are connected form a carbonyl group and Re represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4; with the proviso that the following compounds and compounds of Formula (I’) are excluded: o when A represents CH2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0; when A represents CH2 or C(O) and Ra represents H2N-CH2-, m represents an integer of 1 and n represents an integer of 0; when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; and the compounds of Formula (I’): Formula (I’) wherein in Formula (I’), A represents CH2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

[0009] In another aspect, the protein degrader compounds of the present disclosure can be compounds of Formula (II): PBM-Rf-LIN-ULM Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein PBM-Rf- represents a targeting moiety capable of binding protein, ULM represents a E3 ubiquitin ligase ligand moiety, LIN is a linker moiety, and PBM-Rf- is covalently bonded to ULM through LIN; ULM represents the structure of Formula (ULM): 0 Formula (ULM) wherein A represents CO, CH2 or CD2; Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl; (Rb)n indicates that the benzene ring is optionally substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated Ci-6 alkyl, optionally deuterated Ci-6 alkoxy, halogenated Ci-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6alkynyl; n represents an integer of 0, 1, 2 or 3; LIN represents the structure of the following formula: wherein R5 and Re are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; Rf represents a bond, -0-, -N(Rg)-, -NHC(0)-Rh-W5-*, -C(0)NH-Rh-W5-*, -NHC(0)-W5-*, -C(0)NH-W5-*, -NHC(O)-*, -C(0)NH-*, -O-Rh-W5-*, -0-W5-*, -0-Rh-N(Ri)-*, -N(Rg)-Rh-N(Ri)-*, -W5-, -W5-N(Rg)-*, -N(Rg)-W5-*, -N(Rg)-W5-N(Ri)-*, -Rh-W5-*, -Rh-C(0)-W5-*, -C(0)-W5-*, -Rh-C(O)NH-Rj-W5-*, -Rh-NHC(O)-Rj-W5-*, -Rh-C(0)NH-*, -Rh-NHC(0)-*, -Rh-, -Rh-N(Ri)-*, or = w5—* wherein W5 represents the structure of the following formula: -|-R w7tt€ wOyb * (Ra3)m3 (Ra2)m2 wherein each ring W6 is the same or different and each independently represents nitrogencontaining heterocyclylene, tl represents an integer of 1 or 2, and (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, where Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m2 represents an integer of 0-20; each ring W7 is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, and (Ra3)m3 indicates that each ring W7 is independently optionally substituted with m3 Ra3 substituents, with each Ra3 being independently deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; and Rg and Ri each independently represent hydrogen or C1-6 alkyl, Rh and Rj each independently represent optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and symbol * indicates the point of attachment to LIN; wherein when PBM represents the structure of the following formula: X—N   N—' and simultaneously -Rf-LIN- represents      '—f    , where symbol ** indicates the point of attachment to ULM, (Rb)n indicates that benzene ring of Formula (ULM) is substituted with 1, 2, or 3 Rb, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl, or C2-6 alkynyl; with the proviso that the following compounds are excluded: 3-(4-((3-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-<7]pyrimi din- l-yl)piperi din-1-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3- dioxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -y 1)-3 -oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-l-yl)imidazo[ 1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)methyl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperi din-3 -y 1)-5-((3 -(4-(6-(6-(2-(3 -fluorophenyl)pyrrolidin-1 -yl)imidazo [1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)isoindoline-1,3-dione.

[0010] In a further aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

[0011] In a further aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

[0012] In a further aspect, the present disclosure further provides a medicine kit or reagent kit comprising: the compound of Formula (I) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same; or the compound of Formula (II) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same.

[0013] In a further aspect, the present disclosure provides the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use as a medicament.

[0014] In a further aspect, the present disclosure provides the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use in the prevention or treatment of cereblon protein-mediated disease or disorder.

[0015] In some embodiments, the cereblon protein-mediated disease or disorder includes, but not limited to, tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, or diabetes.

[0016] In a further aspect, the present disclosure provides the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use as a medicament.

[0017] In a further aspect, the present disclosure provides the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use in the treatment and / or prevention of a disease or disorder selected from the group consisting of tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease.

[0018] In a further aspect, the present disclosure provides use of the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the preparation of the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof of the present disclosure.

[0019] In a further aspect, the present disclosure also provides a method for preparing the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof of the present disclosure by using the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof.

[0020] In a further aspect, the present disclosure provides use of the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the manufacture of a medicament for the prevention or treatment of cereblon protein-mediated disease or disorder.

[0021] In a further aspect, the present disclosure provides use of the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the manufacture of a medicament for the prevention and / or treatment of a disease or disorder selected from the group consisting of tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease.

[0022] In a further aspect, the present disclosure provides a method for treating or preventing a cereblon protein-mediated disease or disorder in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same.

[0023] In a further aspect, the present disclosure provides a method for treating or preventing a disease or disorder in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same, wherein the disease or disorder comprises tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease. Detailed Description of the Invention

[0024] The following detailed description is provided as exemplary specific embodiments to assist those skilled in the art in understanding and practicing the present disclosure. It should be appreciated, however, that such description is not intended to limit the scope of the present disclosure, and that various modifications and changes may be made to the specific embodiments described in the present disclosure without departing from the spirit and scope of the present disclosure. Such changes and modifications are to be understood as being included within the scope of the present invention as defined by the appended claims. I. Compounds Compounds of Formula (I)

[0025] The present disclosure provides a compound of Formula (I) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof: o' Formula (I) wherein A, Ri, R2, R3, R4, (Ra)m, (Rb)n, m and n are s defined in the compounds of Formula (I) above.

[0026] In some embodiments, Ri, R2, R3 and R4 of the compound of Formula (I) are the same or different and each independently represent hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-).

[0027] In some embodiments, Ri, R2, R3 and R4 of the compound of Formula (I) are the same or different and each independently represent hydrogen or deuterium.

[0028] In some embodiments, Ri, R2, R3 and R4 of the compound of Formula (I) represent hydrogen.

[0029] In some embodiments, A of the compound of Formula (I) represents CO.

[0030] In some embodiments, A of the compound of Formula (I) represents CH2.

[0031] In some embodiments, A of the compound of Formula (I) represents CD2.

[0032] In some embodiments, m of the compound of Formula (I) represents an integer of 1, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4.

[0033] In some embodiments, m of the compound of Formula (I) represents an integer of 2, n represents an integer of 0, 1, or 2, and the sum of m and n is an integer of 2, 3, or 4.

[0034] In some embodiments, when R and Rs together with the carbon atom to which they are connected form a carbonyl group and R& represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4. In some subembodiments, m represents an integer of 1, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4. In some sub-embodiments, m represents an integer of 2, n represents an integer of 1 or 2, and the sum of m and n is an integer of 3 or 4. In some sub-embodiments, m represents an integer of 3, n represents an integer of 1.

[0035] In some embodiments, R of the compound of Formula (I) represents chlorine, bromine, iodine, hydroxy, leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)).

[0036] In some embodiments, R of the compound of Formula (I) represents NR7R8, wherein R7 and Rs are the same or different and each independently represent hydrogen, C1-6 alkyl (e.g., Cm alkyl or Ci-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C2-6 alkynyl-Ci-6 alkylene- (e.g., C2-6alkynyl-Ci-4 alkylene- or C2-6 alkynyl-Ci-3 alkylene-, such as ethynyl-methylene-, ethynyl-ethylene-, ethynyl-propylene-, ethynyl-butylene-, ethynyl-pentylene-, or ethynyl-hexylene-), C2-6 alkenyl-Ci-6 alkylene- (e.g., C2-6 alkenyl-Ci-4 alkylene- or C2-6 alkenyl-Ci-3 alkylene-, such as vinyl-methylene-, vinyl-ethylene-, vinyl-propylene-, vinyl-butylene-, vinyl-pentylene-, or vinyl-hexylene-), optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15membered, or 5- to 9-membered) nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing bridged heterocyclyl, optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15membered, or 5- to 9-membered) nitrogen-containing spiro-heterocyclyl, or R2a-Rla-, where Rla is optionally substituted C1-6 alkylene (e.g., optionally substituted C1-4 alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), and R2a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), amino, hydroxy, carboxyl, CHO, C2-6 alkynyl (e.g., C2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl) or a leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)). The 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15-membered nitrogencontaining spiro-heterocyclyl are each independently optionally substituted with one or more (e.g., 110, such as 1,2, 3, 4, 5, 6, 8, or 10) substituents selected from the group consisting of deuterium, C1-6 alkyl (e.g., C1-4 alkyl or C1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C1-6 alkoxy (e.g., C1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, carboxyl, CHO, C2-6 alkynyl (e.g., C2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl), R4a-R3a-, or any combination thereof, where R3a represents optionally substituted C1-6 alkylene (e.g., optionally substituted C1-4 alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl (e.g., methyl, ethyl, or propyl). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units. For example, when the substituent is deuterium, the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally perdeuterated or partially deuterated.

[0037] In some sub-embodiments, R of the compound of Formula (I) represents NR?Rs, wherein R7 and Rs are the same or different and each independently represent: hydrogen, C1-6 alkyl, C2-6 alkynyl-Ci-6 alkylene-, or C2-6 alkenyl-Ci-6 alkylene-; or optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, or optionally substituted 4-to 15-membered nitrogen-containing spiro-heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1 ]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl,      diazabicyclo [3.1.1 ]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3- azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or R2a-Rla-5 wherein Rla represents optionally substituted Ci-6 alkylene or optionally substituted C2-6 alkenylene, and R2a represents halogen, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, or leaving group, and wherein the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, 4- to 15-membered nitrogen-containing bridged heterocyclyl and 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally substituted with one or more (e.g., 1-10, such as 1,2, 3, 4, 5, 6, 8, or 10) substituents selected from the group consisting of deuterium, C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, R4a-R3a-, or any combination thereof, wherein R3a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl. The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units. For example, when the substituent is deuterium, the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogencontaining bridged heterocyclyl, and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally perdeuterated or partially deuterated.

[0038] In some embodiments, R of the compound of Formula (I) represents NH2, -NHCH3, - M              H            I H NHCH2CH3, -N(CH3)2, -N(CH3)-CH2CH3, -N(CH3)-CH2CH2Br, HN^ , HN^ , HN^ , or o—'       .

[0039] In some embodiments, R of the compound of Formula (I) represents W1 represented by the structure of the following formula: (Ra1)mi wherein ring W2 represents 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4-to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclyl, e.g., 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5-to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, (Ral)mi indicates that ring W2 is optionally substituted with ml Ral substituents, with each Ral being independently deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), C1-6 alkoxy (e.g., C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, or tert-butoxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6alkynyl (e.g., C2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R8a-R7a-, wherein R7a is optionally substituted C1-6 alkylene (e.g., optionally substituted Ci-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted vinylene, propenylene, butenylene); and R8a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R9aR10aN-5 hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl (e.g., methyl, ethyl, or propyl); wherein ml represents an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0040] In some sub-embodiments, R of the compound of Formula (I) represents W1 represented by the structure of the following formula: (Ra1)m1 wherein ring W2 represents 4- to 20-membered nitrogen-containing heterocyclyl, e.g., 4- to 20membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4-to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl,           azabicyclo [3.1.1 ]heptanyl,           azabicyclo[2.2.1 ]heptanyl, azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl,      diazabicyclo [3.1.1 ]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or (Ral)mi indicates that ring W2 is optionally substituted with ml Ral substituents, with each Ral being independently deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R8a-R7a-, wherein R7a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R8a represents halogen, R9aR10aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl; wherein ml represents an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0041] In some embodiments, ring W2 is optionally perdeuterated or partially deuterated.

[0042] In some embodiments, R of the compound of Formula (I) represents W1 represented by the structure of the following formula: (Ra3)m3   (Ra2)m2 wherein each ring W3 is the same or different and each independently represents 4- to 20membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4-to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclylene, e.g., 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4-to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclylene containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur; t represents an integer of 1 or 2, and (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated Ci-6 alkyl (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C1-6 alkoxy (e.g., C1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl (e.g., C2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R12a-Rlla-, wherein Rllais optionally substituted C1-6 alkylene (e.g., optionally substituted C1-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted methylene, ethylene or propylene), and R12a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl (e.g., methyl, ethyl, or propyl); and ring W4 represents 4- to 15-membered (e.g., 4- to 12-membered, 4- to 11-membered, 4- to 10membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15membered, or 5- to 9-membered) nitrogen-containing heterocyclyl (e.g., 4- to 15-membered (e.g., 4-to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4-to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur), 6- to 10-membered aryl, or 5- to 10-membered (e.g., 5- to 6-membered, or 5- to 9-membered) heteroaryl (e.g., 5- to 10-membered (e.g., 5- to 9-membered, 5- to 8-membered, 5- to 7-membered, or 5- to 6-membered) heteroaryl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur); (Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated Ci-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), C1-6 alkoxy (e.g., Ci-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl (e.g., C2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene (e.g., optionally substituted C1-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted vinylene, propenylene, butenylene), and R16a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl (e.g., methyl, ethyl, or propyl); wherein m2 and m3 each independently represent an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0043] In some sub-embodiments, R of the compound of Formula (I) represents W1 represented by the structure of the following formula: (Ra3)m3   (Ra2)m2 wherein each ring W3 is the same or different and each independently represents 4- to 20membered nitrogen-containing heterocyclylene, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo [3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, or t represents an integer of 1 or 2, and (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, wherein Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and ring W4 represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1 ]heptanyl, azabicyclo[2.2.1 ]heptanyl, azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl,       diazabicyclo [3.1.1 ]heptanyl,       diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,l,3]oxadiazolyl, benzo[2,l,3]thiadiazolyl, benzo[l,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[l,5-a]pyridyl, pyrazolo[l,5-a]pyrimidinyl, imidazo[l,2-a]pyridyl, lH-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,l-b]thiazolyl, or imidazo[2,l-b]thiazolyl; or I I (Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl; wherein m2 and m3 each independently represent an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0044] In some sub-embodiments, each ring W3 is independently optionally perdeuterated or partially deuterated.

[0045] In some sub-embodiments, ring W4 is optionally perdeuterated or partially deuterated.

[0046] In some sub-embodiments, R of the compound of Formula (I) represents the following groups: chlorine, bromine, iodine, hydroxy, -N3, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-), NH2, or

[0047] In some embodiments, Rs and Re of the compound of Formula (I) each independently represent: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rd and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 18, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl (e.g., C1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated Ci-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated C1-4 alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 115, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C1.6 alkylene (e.g., NH2-C1. 3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated Ci-4 alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof.

[0048] In some embodiments, Rs of the compound of Formula (I) represents hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, optionally substituted methoxy, optionally substituted ethoxy, optionally substituted propoxy, optionally substituted butoxy, or optionally substituted tert-butoxy.

[0049] In some embodiments, R and Rs together with the carbon atom to which they are connected of the compound of Formula (I) form carbonyl group. In other words, Ra of the compound of Formula (I) represents the following group: R6 wherein Re is as defined above.

[0050] In some embodiments, R and Rs are as defined in the compound of Formula (I) above and any one of its embodiments, and Re represents: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rd and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 16, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl (e.g., C1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated C1-4 alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 115, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C1.6 alkylene (e.g., NH2-C1. 3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated Ci-4 alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof.

[0051] In some sub-embodiments, Re of the compound of Formula (I) represents hydrogen, fluorine, chlorine, bromine, or iodine.

[0052] In some sub-embodiments, Re of the compound of Formula (I) represents the structure of the following formula: -Ci-30 alkyl; -(C(Ra4)(R“)^ -(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))nHRc-(C(Ra6)(Ra7)^ -(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))nl-(Rd-(C(Ra6)(Ra7))n2)m4W^ -(C(Ra4)(Ra5))nHRd-(C(Ra6)(R^ -(C(Ra4)(Ra5))ni-(Rc-Rd-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))ni-(Rd-Rc-(C(Ra6)(Ra7))n2)m4-H;or -(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or Ci-6 alkyl; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C5-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 5- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated Cm alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated Ci-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated Ci-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated Cm alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano, or any combination thereof; a hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH2 of Ci-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C1-6 alkyl (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C1-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated Cm alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tertbutoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C1.6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated Ci-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated Cm alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated Ci-6 alkyl (e.g., optionally deuterated Ci-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated Ci-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, C1CH2-, C12CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2C1CH2-), optionally deuterated C3.6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated Ci-6 alkoxy (e.g., optionally deuterated Cm alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated Ci-6 alkyl-NH- (e.g., optionally deuterated Ci.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-Ci-6 alkylene (e.g., NH2-Ci-3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated Ci-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), or optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated Cm alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-); and nl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0053] In some sub-embodiments, Re of the compound of Formula (I) represents the structure of the following formula: -(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-(O^ -(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9)^ -(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))nHN(R j-(C(Ra6)(Ra7))n^^ -(C(Ra4)(Ra5))nHC(OM -(C(Ra4)(Ra5))nHC(O)N(Rc)-(C(Ra6)^ -(C(Ra4)(Ra5))ni-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-(C(O)N(Re)-(C(Ral0)(Rall))n4)m6-H; -(C(Ra4)(Ra5))nHC(O)N(Rc)-(C^ -(C(Ra4)(Ra5))nrC(O)N(Rc)-(C^ -(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4<^ -(C(Ra4)(Ra5))nHN(Re)C(O)-(C(Ra6)(Ra7))n / ^^ -(C(Ra4)(Ra5))ni-N(Re)C(O)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H; -(C(Ra4)(Ra5))ni-N(Re)C(OW -(C(Ra4)(Ra5))ni-C(O)-(C(Ra6)(Ra7))n2-H; -(C(Ra4)(Ra5))ni-(arylene-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))nHarylene-(a^ -(C(Ra4)(Ra5))ni-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))nHhelerocycly^ -(C(Ra4)(Ra5))nH -(C(Ra4)(Ra5))nHhelero^^^ -(C(Ra4)(Ra5))nHcy^ -(C(Ra4)(Ra5))nHcycloalky^^ wherein each Re independently represents H or Ci-6 alkyl (e.g., C1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); the cycloalkylene (e.g., C3-20 cycloalkylene, C3-15 cycloalkylene, C3-10 cycloalkylene, C3-8 cycloalkylene, or C3-6 cycloalkylene), arylene (e.g., C5-20 arylene, C5-15 arylene, C5-10 arylene, or C5-6 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, 4- to 15-membered heterocyclylene, 4- to 10-membered heterocyclylene, 4- to 9-membered heterocyclylene, 4- to 8membered heterocyclylene, 5- to 7-membered heterocyclylene, or 6-membered heterocyclylene) and heteroarylene (e.g., 5- to 20-membered heteroarylene, 5- to 15-membered heteroarylene, 5- to 10membered heteroarylene, 5- to 9-membered heteroarylene, 5- to 8-membered heteroarylene, 5- to 7membered heteroarylene, or 6-membered heteroarylene,) are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated Ci-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1-3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated C1-4 alkyl-NHC(O)-, such as CH3-NHC(0)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano, or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated Ci-6 alkyl (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C1-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, C1CH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2C1CH2-), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated Cm alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-Ci-6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), or optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated Cm alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-); and nl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0054] In some sub-embodiments, Re of the compound of Formula (I) represents the following groups: H, fluorine, chlorine, bromine, iodine, -CH3, -CH2-CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2)io-CH3, -(CH2)h-CH3, -(CH2)i2-CH3, -(CH2)i3-CH3, -(CH2)i4-CH3, -(CH2)i5-CH3, -(CH2)i6-CH3, -(CH2)i7-CH3, -(CH2)i8-CH3, -(CH2)19-CH3, -(CH2)2o-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)25-CH3, -(CH2)29-CH3;-CH2-O-CH3, -CH2-O-CH2-CH3, -CH2-O-(CH2)2-CH3, -(CH2)i-O-(CH2)3-CH3, -(CH2)i-O-(CH2)4-CH3, -(CH2)i-O-(CH2)5-CH3, -(CH2)1-O-(CH2)6-CH3, -(CH2)1-O-(CH2)7-CH3, -(CH2)1-O-(CH2)8-CH3, -(CH2)i-O-(CH2)9-CH3, -(CH2)i-0-(CH2)io-CH3, -(CH2)2-O-CH3, -(CH2)2-O-CH2-CH3, -(CH2)2-O-(CH2)2-CH3, -(CH2)2-O-(CH2)3-CH3, -(CH2)2-O-(CH2)4-CH3, -(CH2)2-O-(CH2)5-CH3, -(CH2)2-O-(CH2)6-CH3, -(CH2)2-O-(CH2)7-CH3, -(CH2)2-O-(CH2)8-CH3, -(CH2)2-O-(CH2)9-CH3, -(CH2)2-0-(CH2)io-CH3, -(CH2)2-O-(CH2)11-CH3, -(CH2)2-O-(CH2)i2-CH3, -(CH2)3-O-CH3, -(CH2)3-O-CH2-CH3, -(CH2)3-O-(CH2)2-CH3, -(CH2)3-O-(CH2)3-CH3, -(CH2)3-O-(CH2)4-CH3, -(CH2)3-O-(CH2)5-CH3, -(CH2)3-O-(CH2)6-CH3, -(CH2)3-O-(CH2)7-CH3, -(CH2)4-O-CH3, -(CH2)4-O-CH2-CH3, -(CH2)4-O-(CH2)2-CH3, -(CH2)4-O-(CH2)3-CH3, -(CH2)4-O-(CH2)4-CH3, -(CH2)4-O-(CH2)5-CH3, -(CH2)4-O-(CH2)6-CH3, -(CH2)5-O-CH3, -(CH2)5-O-CH2-CH3, -(CH2)5-O-(CH2)2-CH3, -(CH2)5-O-(CH2)3-CH3, -(CH2)5-O-(CH2)4-CH3, -(CH2)5-O-(CH2)5-CH3, -(CH2)6-O-CH3, -(CH2)6-O-CH2-CH3, -(CH2)6-O-(CH2)2-CH3, -(CH2)6-O-(CH2)3-CH3, -(CH2)6-O-(CH2)4-CH3, -(CH2)7-O-CH3, -(CH2)7-O-CH2-CH3, -(CH2)7-O-(CH2)2-CH3, -(CH2)7-O-(CH2)3-CH3, -(CH2)8-O-CH3, -(CH2)8-O-CH2-CH3, -(CH2)8-O-(CH2)2-CH3, -CH(CH3)-O-CH3, -CH(CH3)-O-CH2-CH3, -CH(CH3)-O-(CH2)2-CH3, -CH(CH3)-O-(CH2)3-CH3, - CH(CH3)-O-(CH2)4-CH3, -CH(CH3)-O-(CH2)5-CH3, -CH(CH3)-O-(CH2)6-CH3, -CH(CH3)-O-(CH2)7-CH3, -CH(CH3)-O-(CH2)8-CH3, -CH(CH3)-O-(CH2)9-CH3, -CH(CH3)-0-(CH2)io-CH3, -ch2-(O(CH2)2)i-OCH2CH3, -CH2-(O(CH2)2)2-OCH2CH3, -CH2-(O(CH2)2)3-OCH2CH3, -CH2-(O(CH2)2)4-OCH2CH3, -CH2-(O(CH2)2)5-OCH2CH3, -CH2-(O(CH2)2)6-OCH2CH3, -CH2-(O(CH2)2)7-OCH2CH3, -CH2-(O(CH2)2)8-OCH2CH3, -CH2-(O(CH2)2)9-OCH2CH3, -CH2-(0(CH2)2)io-OCH2CH3, -ch2-(O(CH2)2)i-OCH3, -CH2-(O(CH2)2)2-OCH3, -CH2-(O(CH2)2)3-OCH3, -CH2-(O(CH2)2)4-OCH3, -ch2-(O(CH2)2)5-OCH3, -CH2-(O(CH2)2)6-OCH3, -CH2-(O(CH2)2)7-OCH3, -CH2-(O(CH2)2)8-OCH3, -ch2-(O(CH2)2)9-OCH3, -CH2-(0(CH2)2)io-OCH3, -(CH2)2-(O(CH2)2)1-OCH2CH3, -(CH2)2-(O(CH2)2)2-OCH2CH3, -(CH2)2-(O(CH2)2)3-OCH2CH3, -(CH2)2-(O(CH2)2)4-OCH2CH3, -(CH2)2-(O(CH2)2)5-OCH2CH3, -(CH2)2-(O(CH2)2)6-OCH2CH3, -(CH2)2-(O(CH2)2)7-OCH2CH3, -(CH2)2-(O(CH2)2)8-OCH2CH3, -(CH2)2-(O(CH2)2)9-OCH2CH3, -(CH2)2-(0(CH2)2)io-OCH2CH3, -(CH2)3-(O(CH2)2)1-OCH2CH3, -(CH2)3-(O(CH2)2)2-OCH2CH3, -(CH2)3-(O(CH2)2)3-OCH2CH3, -(CH2)3-(O(CH2)2)4-OCH2CH3, -(CH2)3-(O(CH2)2)5-OCH2CH3, -(CH2)3-(O(CH2)2)6-OCH2CH3, -(CH2)3-(O(CH2)2)7-OCH2CH3, -(CH2)3-(O(CH2)2)8-OCH2CH3, -(CH2)3-(O(CH2)2)9-OCH2CH3, -(CH2)3-(0(CH2)2)io-OCH2CH3, -(CH2)4-(O(CH2)2)i-OCH2CH3, -(CH2)4-(O(CH2)2)2-OCH2CH3, -(CH2)4-(O(CH2)2)3-OCH2CH3, -(CH2)4-(O(CH2)2)4-OCH2CH3, <CH2MO(CH2)2)5-OCH2CH3, -(CH2)4-(O(CH2)2)6-OCH2CH3, -(CH2)4-(O(CH2)2)7-OCH2CH3, <CH2MO(CH2)2)8-OCH2CH3, -(CH2)4-(O(CH2)2)9-OCH2CH3, -(CH2)4-(0(CH2)2)io-OCH2CH3, -CH2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)3)4-OCH2CH2CH3, -CH2-(O(CH2)3)5-OCH2CH2CH3, -CH2-(O(CH2)3)6-OCH2CH2CH3, -CH2-(O(CH2)3)7-OCH2CH2CH3, -CH2-(O(CH2)3)8-OCH2CH2CH3, -CH2-(O(CH2)3)9-OCH2CH2CH3,   -CH2-(0(CH2)3)io-OCH2CH2CH3,   -(CH2)2- (O(CH2)3)i-OCH2CH2CH3, -(CH2)2-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)3)3-OCH2CH2CH3, -(CH2)2-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)6- OCH2CH2CH3, -(CH2)2-(O(CH2)3)7-OCH2CH2CH3, -(CH2)2-(O(CH2)3)8-OCH2CH2CH3, -(CH2)3-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)3)3-OCH2CH2CH3, -(CH2)3-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)6- OCH2CH2CH3, -(CH2)3-(O(CH2)3)7-OCH2CH2CH3, -(CH2)3-(O(CH2)3)8-OCH2CH2CH3, -ch2-o-(CH2)2-O-(CH2)2-CH3, -CH2-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -CH2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,    -CH2-(O(CH2)2)5-(O(CH2)3)4- OCH2CH2CH3, -(CH2)2-O-(CH2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -(CH2)2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-O-(CH2)2-O-(CH2)2CH3, -(CH2)3-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,   -(CH2)3-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3,   -CH2-O-(CH2)3-O- CH2CH3, -CH2-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, -CH2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -ch2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -CH2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)2-O-(CH2)3-O- CH2CH3, -(CH2)2-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, -(CH2)2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)3-O-(CH2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, <CH2MO(CH2)3)3-(O(CH2)2)2-O- CH2CH3, -(CH2)3-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, - CH2-O-(CH2)2-O-CH3, -(CH2)2-O-(CH2)2-O-CH3, -(CH2)2-(O(CH2)2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)3-O-(CH2)2CH3, <CH2MO(CH2)2)4-O-(CH2)2CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)4CH3, - (CH2)5-(O(CH2)2)2-O-(CH2)5CH3, -(CH2)i-N(Re)-CH3, -(CH2)i-N(Re)-(CH2)i-CH3, -(CH2)i-N(Re)- (CH2)2-CH3, -(CH2)i-N(Re)-(CH2)3-CH3, -(CH2)i-N(Re)-(CH2)4-CH3, -(CH2)i-N(Re)-(CH2)5-CH3, -(CH2)i-N(Re)-(CH2)6-CH3, -(CH2)i-N(Re)-(CH2)7-CH3, -(CH2)i-N(Re)-(CH2)8-CH3, -(CH2)i-N(Re)- (CH2)9-CH3, -(CH2)2-N(Re)-CH3, -(CH2)2-N(Re)-(CH2)i-CH3, -(CH2)2-N(Re)-(CH2)2-CH3, -(CH2)2-N(Re)-(CH2)3-CH3, -(CH2)2-N(Re)-(CH2)4-CH3, -(CH2)2-N(Re)-(CH2)5-CH3, -(CH2)2-N(Re)-(CH2)6-CH3, -(CH2)2-N(Re)-(CH2)7-CH3, -(CH2)2-N(Re)-(CH2)8-CH3, -(CH2)2-N(Re)-(CH2)9-CH3, -(CH2)2- N(Re)-(CH2)io-CH3, -(CH2)2-N(Re)-(CH2)ii-CH3, -(CH2)3-N(Re)-CH3, -(CH2)3-N(Re)-(CH2)i-CH3, -(CH2)3-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-CH3, -(CH2)4-N(Re)-(CH2)i-CH3, -(CH2)4-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-CH3, -(CH2)5-N(Re)-(CH2)i-CH3, -(CH2)5-N(Re)- (CH2)2-CH3, -(CH2)5-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-(CH2)4-CH3, -(CH2)6-N(Re)-CH3, -(CH2)6-N(Re)-(CH2)i-CH3, -(CH2)6-N(Re)-(CH2)2-CH3, -(CH2)7-N(Re)-CH3, -(CH2)7-N(Re)-(CH2)i-CH3, -(CH2)7-N(Re)-(CH2)2-CH3, -(CH2)8-N(Re)-CH3, -(CH2)8-N(Re)-(CH2)i-CH3, -(CH2)8-N(Re)-(CH2)2- CH3, -CH(CH3)-N(Re)-CH3, -CH(CH3)-N(Re)-(CH2)i-CH3, -CH(CH3)-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-(CH2)3-CH3, -CH(CH3)-N(Re)-(CH2)4-CH3, -CH(CH3)-N(Re)-(CH2)5-CH3, -CH(CH3)-N(Re)-(CH2)6-CH3, -CH(CH3)-N(Re)-(CH2)7-CH3, -CH(CH3)-N(Re)-(CH2)8-CH3, -CH(CH3)-N(Re)-(CH2)9- CH3, -CH2C(O)NHCH3, (CH2)2C(O)NH(CH2)3-CH3, (CH2)3C(O)NH(CH2)3-CH3, (CH2)6C(O)NH(CH2)6-CH3, (CH2)8C(O)NH(CH2)7-CH3, -(CH2)2C(O)NHCH2CH3, -(CH2)2C(O)NH(CH2)4-CH3, -(CH2)4C(O)NH(CH2)3-CH3, -(CH2)6C(O)NH(CH2)5-CH3, U-(CH2)9C(O)NH(CH2)8-CH3, (CH2)2C(O)NH(CH2)2-O-CH2-CH3, -CH2NHC(O)CH3, (CH2)2NHC(O)(CH2)2-CH3, (CH2)3NHC(O)(CH2)2-CH3, (CH2)5NHC(O)(CH2)4-CH3, (CH2)7NHC(O)(CH2)6-CH3, (CH2)ioNHC(0)(CH2)9-CH3, -(CH2)2NHC(O)(CH2)3-CH3, -(CH2)3NHC(O)(CH2)3-CH3, -(CH2)6NHC(O)(CH2)6-CH3, -(CH2)8NHC(O)(CH2)7-CH3, -(CH2)4NHC(O)(CH2)7-CH3, -(CH2)2C(O)NH(CH2)2-CH3, -(CH2)3C(O)NH(CH2)2-CH3, -(CH2)5C(O)NH(CH2)4-CH3, -(CH2)7C(O)NH(CH2)6-CH3, -(CH2)ioC(0)NH(CH2)9-CH3, -(CH2)2NHC(O)CH2CH3, -(CH2)2NHC(O)(CH2)4-CH3, -(CH2)4NHC(O)(CH2)3-CH3, -(CH2)6NHC(O)(CH2)5-CH3, -(CH2)9NHC(O)(CH2)8-CH3, -(CH2)2NHC(O)(CH2)2-O-CH2-CH3, (CH2)4NHC(O)CH3, -CH2-piperidinylene-CH3, -CH2-piperidinylene-CH2-CH3, -CH2-piperidinylene-(CH2)2-CH3, -CH2-piperidinylene-(CH2)3-CH3, -CH2-piperidinylene-(CH2)4-CH3, -CH2-piperidinylene-(CH2)5-CH3, -CH2-piperidinylene-(CH2)6-CH3, -CH2-piperidinylene-(CH2)7-CH3, ■ (CH2)2-piperidinylene-CH3, -(CH2)2-piperidinylene-CH2-CH3, -(CH2)2-piperidinylene-(CH2)2-CH3, ■ (CH2)2-piperidinylene-(CH2)3-CH3, -(CH2)2-piperidinylene-(CH2)4-CH3, -(CH2)2-piperidinylene-(CH2)s-CH3, -(CH2)2-piperidinylene-(CH2)6-CH3, -(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)3-piperidinylene-CH3, -(CH2)3-piperidinylene-CH2-CH3, -(CH2)3-piperidinylene-(CH2)2-CH3, -(CH2)3-piperidinylene-(CH2)3-CH3, -(CH2)3-piperidinylene-(CH2)4-CH3, -(CH2)3-piperidinylene-(CH2)s-CH3, -(CH2)3-piperidinylene-(CH2)6-CH3, -(CH2)3-piperidinylene-(CH2)7-CH3, -(CH2)4-piperidinylene-CH3, -(CH2)4-piperidinylene-CH2-CH3, -(CH2)4-piperidinylene-(CH2)2-CH3, -(CH2)4-piperidinylene-(CH2)3-CH3, -(CH2)4-piperidinylene-(CH2)4-CH3, -(CH2)4-piperidinylene-(CH2)5-CH3, -(CH2)4-piperidinylene-(CH2)6-CH3, -(CH2)4-piperidinylene-(CH2)7-CH3, -(CH2)5-piperidinylene-CH3, -(CH2)5-piperidinylene-CH2-CH3, -(CH2)5-piperidinylene-(CH2)2-CH3, -(CH2)5-piperidinylene-(CH2)3-CH3, -(CH2)5-piperidinylene-(CH2)4-CH3, -(CH2)5-piperidinylene-(CH2)5-CH3, -(CH2)s-piperidinylene-(CH2)6-CH3, -(CH2)5-piperidinylene-(CH2)7-CH3, -(CH2)6-piperidinylene-CH3, -(CH2)6-piperidinylene-CH2-CH3, -(CH2)6-piperidinylene-(CH2)2-CH3, -(CH2)6-piperidinylene-(CH2)3-CH3, -(CH2)6-piperidinylene-(CH2)4-CH3, -(CH2)6-piperidinylene-(CH2)5-CH3, -(CH2)6-piperidinylene-(CH2)6-CH3, -(CH2)6-piperidinylene-(CH2)7-CH3, -(CH2)7-piperidinylene-CH3, -(CH2)7-piperidinylene-CH2-CH3, -(CH2)7-piperidinylene-(CH2)2-CH3, -(CH2)7-piperidinylene-(CH2)3-CH3, -(CH2)7-piperidinylene-(CH2)7-CH3, -(CH2)8-piperidinylene-CH3, -(CH2)8-piperidinylene-CH2-CH3, -(CH2)8-piperidinylene-(CH2)2-CH3, -(CH2)8-piperidinylene-(CH2)3-CH3, -(CH2)s-piperidinylene-(CH2)4-CH3, -(CH2)8-piperidinylene-(CH2)5-CH3, -(CH2)8-piperidinylene-(CH2)6-CH3, -(CH2)8-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -CH2-N(Rj-CH2-pipe^                   - CH2-N(Re)-(CH2)2-piperidinylene-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH2-CH3, (CH2)2-piperidinylene-(CH2)2-CH3, (CH2)2-piperidinylene-(CH2)4-CH3, (CH2)2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)- -CH2-N(Re)- -CH2-N(Re)- -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)- CH2-piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3, piperidinylene-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-CH2-CH3, piperidinylene-(CH2)2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)7-CH3, piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)5-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)6-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)-CH2- -(CH2)2-N(Re)-CH2- -(CH2)2-N(Re)-CH2- -(CH2)3-N(Re)-CH2- -(CH2)3-N(Re)-CH2- -(CH2)4-N(Re)-CH2- -(CH2)4-N(Re)-CH2- -(CH2)5-N(Re)-CH2- -(CH2)6-N(Re)-CH2- -(CH2)7-N(Re)-CH2- piperidinylene-(CH2)2-CH3, -(CH2)7-N(Re)-CH2-piperidinylene-(CH2)7-CH3, piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)8-N(Rj-C^ -(CH2)8-N(Re)-CH2- -(CH2)8-N(Re)-CH2- -(CH2)8-N(Re)-CH2- -(CH2)8-N(Re)-CH2- -CH2-piperazinylene- CH3, -CH2-piperazinylene-CH2-CH3, -CH2-piperazinylene-(CH2)2-CH3, -CH2-piperazinylene-(CH2)3- CH3, -CH2-piperazinylene-(CH2)4-CH3, -CH2-piperazinylene-(CH2)s-CH3, -CH2-piperazinylene-(CH2)6-CH3, -CH2-piperazinylene-(CH2)7-CH3, -(CH2)2-piperazinylene-CH3, -(CH2)2-piperazinylene-CH2-CH3, -(CH2)2-piperazinylene-(CH2)2-CH3, -(CH2)2-piperazinylene-(CH2)3-CH3, -(CH2)2-piperazinylene-(CH2)4-CH3, -(CH2)2-piperazinylene-(CH2)s-CH3, -(CH2)2-piperazinylene-(CH2)6-CH3, -(CH2)2-piperazinylene-(CH2)7-CH3, -(CH2)3-piperazinylene-CH3, -(CH2)3-piperazinylene-CH2-CH3, -(CH2)3-piperazinylene-(CH2)2-CH3, -(CH2)3-piperazinylene-(CH2)3-CH3, -(CH2)3-piperazinylene-(CH2)4-CH3, -(CH2)3-piperazinylene-(CH2)5-CH3, -(CH2)3-piperazinylene-(CH2)6-CH3, -(CH2)3-piperazinylene-(CH2)7-CH3, -(CH2)4-piperazinylene-CH3, -(CH2)4-piperazinylene-CH2-CH3, -(CH2)4-piperazinylene-(CH2)2-CH3, -(CH2)4-piperazinylene-(CH2)3-CH3, -(CH2)4-piperazinylene-(CH2)4-CH3, -(CH2)4-piperazinylene-(CH2)5-CH3, -(CH2)4-piperazinylene-(CH2)6-CH3, -(CH2)4-piperazinylene-(CH2)7-CH3, -(CH2)5-piperazinylene-CH3, -(CH2)s-piperazinylene-CH2-CH3, -(CH2)5-piperazinylene-(CH2)2-CH3, -(CH2)5-piperazinylene-(CH2)3-CH3, -(CH2)s-piperazinylene-(CH2)4-CH3, -(CH2)5-piperazinylene-(CH2)5-CH3, -(CH2)s-piperazinylene-(CH2)6-CH3, -(CH2)s-piperazinylene-(CH2)7-CH3, -(CH2)6-piperazinylene-CH3, -(CH2)6-piperazinylene-CH2-CH3, -(CH2)6-piperazinylene-(CH2)2-CH3, -(CH2)6-piperazinylene-(CH2)3-CH3, -(CH2)6-piperazinylene-(CH2)4-CH3, -(CH2)6-piperazinylene-(CH2)s-CH3, -(CH2)6-piperazinylene-(CH2)6-CH3, -(CH2)6-piperazinylene-(CH2)7-CH3, -(CH2)7-piperazinylene-CH3, -(CH2)7-piperazinylene-CH2-CH3, -(CH2)7-piperazinylene-(CH2)2-CH3, -(CH2)7-piperazinylene-(CH2)3-CH3, -(CH2)7-piperazinylene-(CH2)7-CH3, -(CH2)8-piperazinylene-CH3, -(CH2)8-piperazinylene-CH2-CH3, -(CH2)8-piperazinylene-(CH2)2-CH3, -(CH2)8-piperazinylene-(CH2)3-CH3, -(CH2)8-piperazinylene-(CH2)4-CH3, -(CH2)8-piperazinylene-(CH2)s-CH3, -(CH2)8-piperazinylene-(CH2)6-CH3, or -(CH2)8-piperazinylene-(CH2)7-CH3; wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tertbutyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated Ci-6 alkyl-NH- (e.g., optionally deuterated C1-3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated Ci-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), NH2-C1-6 alkylene (e.g., NH2-C1-3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated Ci-6 alkyl-NHC(O)- (e.g., optionally deuterated C1-4 alkyl-NHC(O)-, such as CH3-NHC(0)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano, or any combination thereof; a hydrogen atom of CH3 of the groups and a hydrogen atom of one or more (e.g., 1-30, such as 125, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated Ci-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated Ci-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated Ci-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-Ci-6 alkylene (e.g., NH2-C1-3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated Ci-6 alkyl-NHC(O)- (e.g., optionally deuterated C1-4 alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof; ach Re independently represents H or Ci-6 alkyl (e.g., C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); and nl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0055] In some embodiments, Rs and Re of the compound of Formula (I) represent hydrogen.

[0056] In some embodiments, (Rb)n of the compound of Formula (I) indicates that the benzene ring is substituted with n Rb substituents, with each Rb being the same or different and independently representing hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, nitro, amino, cyano, optionally deuterated Ci-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), optionally deuterated Ci-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), halogenated Ci-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, C1CH2-, C12CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2C1CH2-), optionally substituted C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), C2-6 alkenyl (e.g., vinyl, propenyl, or butenyl) or C2-6 alkynyl (e.g., ethynyl, propynyl, or butynyl); and wherein n represents an integer of 0, 1, 2, or 3. In some sub-embodiments, the substituents of the optionally substituted C3-6 cycloalkyl are selected from Ci-C3 alkyl, C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, Ci-C3 alkoxy, Ci-C3 alkyl-NH-, halogenated Ci-C3 alkyl, NH2- Ci-3 alkylene, Ci-3 alkyl-NHC(O)-, Ci-3 alkyl-C(O)NH-, cyano or any combination thereof; and the number of substituents can be one or more (e.g., 1-5, 1-4, 1-3, 1-2, or 1). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0057] In some embodiments, the compound of Formula (I) is also of Formula (1-1) or Formula (1-2): o Formula (I-1)      Formula (1-2) wherein A, Ri, R2, R3, R4, (Rb)n and (Ra)m are as defined in the compound of Formula (I) and its various embodiments above.

[0058] In some embodiments, the compound of Formula (I) is also of Formula (1-3) or Formula (1-4): 0 Formula (1-3) or Formula (1-4) wherein A, (Rb)n and (Ra)m are as defined in the compound of Formula (I) and its various embodiments above.

[0059] In some embodiments, the compound of Formula (I) is also of Formula (1-5), Formula (1-6), Formula (1-7) or Formula (1-8): Formula (1-5) Formula (1-6) Formula (1-7) or Formula (1-8) wherein A, Ri, R2, R3, R4, (Rb)n and Ra are as defined in the compound of Formula (I) and its various embodiments above.

[0060] In some embodiments, in the compounds of Formula (1-5), (1-6), (1-7) or (1-8), A represents CO, CH2 or CD2; Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated Ci-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C1-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, C1CH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2C1CH2-); (Ra)m indicates that benzene ring is substituted with m Ra substituents, with each Ra being the same or different and independently representing the structure of the following formula: R5 wherein R represents chlorine, bromine, iodine, hydroxy, leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, such as methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), NR7R8 or W1, wherein R7 and Rs are the same or different and each independently represent hydrogen, C1-6 alkyl (e.g., Cm alkyl or C1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, secbutyl, tert-butyl, pentyl, or hexyl), C2-6alkynyl-Ci-6 alkylene- (e.g., C2-6alkynyl-CM alkylene-or C2-6 alkynyl-Ci-3 alkylene-, such as ethynyl-methylene-, ethynyl-ethylene-, ethynyl-propylene-, ethynyl-butylene-, ethynyl-pentylene-, or ethynyl-hexylene-), C2-6 alkenyl-Ci-6 alkylene- (e.g., C2-6 alkenyl-Ci-4 alkylene- or C2-6 alkenyl-Ci-3 alkylene-, such as vinylmethylene-, vinyl-ethylene-, vinyl-propylene-, vinyl-butylene-, vinyl-pentylene-, or vinylhexylene-), optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclyl, or R2a-Rla-, where Rla is optionally substituted C1-6 alkylene (e.g., optionally substituted Cm alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C2-6 alkenylene (e.g., optionally substituted C2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), and R2a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), amino, hydroxy, carboxyl, C2-6alkynyl (e.g., C2-4alkynyl, such as ethynyl, propynyl, or butynyl), C2-6 alkenyl (e.g., C2-4 alkenyl, such as vinyl, propenyl, or butenyl) or a leaving group (e.g., -N3, chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)); and W1 represents the structure of the following formula: wherein ring W2 represents optionally substituted nitrogen-containing heterocyclyl (e.g., optionally substituted 4- to 20-membered nitrogen-containing heterocyclyl), and each ring W3 is the same or different and each independently represents optionally substituted nitrogen-containing heterocyclylene (e.g., optionally substituted 4- to 20membered nitrogen-containing heterocyclylene), t represents an integer of 1 or 2, and ring W4 represents optionally substituted aryl (e.g., optionally substituted 6- to 10membered aryl), optionally substituted heteroaryl (e.g., optionally substituted 5- to 10membered heteroaryl) or optionally substituted heterocyclyl (e.g., 4- to 15-membered nitrogen-containing heterocyclyl); Rs and Re are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rd and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 18, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl (e.g., C1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C1-6 alkyl (e.g., halogenated C1-4 alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1-3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated C1-6 alkyl-C(O)NH- (e.g., optionally deuterated C1-4 alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof; or R and Rs together with the carbon atom to which they are connected form carbonyl group, and Re represents hydrogen, optionally substituted methyl, or linear or branched C2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rd and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 115, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl (e.g., C1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl (e.g., optionally deuterated C1-4 alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated C1-4 alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C1-6 alkyl-NH- (e.g., optionally deuterated C1.3 alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated Ci-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), NH2-C1.6 alkylene (e.g., NH2-C1.3 alkylene-, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C1-6 alkyl-NHC(O)- (e.g., optionally deuterated Cm alkyl-NHC(O)-, such as CH3-NHC(0)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), optionally deuterated Ci-6 alkyl-C(O)NH- (e.g., optionally deuterated Cm alkyl-C(O)NH-, such as CH3-C(0)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano, or any combination thereof; (Rb)n indicates that the benzene ring is substituted with n Rb substituents, with each Rb being the same or different and independently representing hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl (e.g., optionally deuterated Cm alkyl, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tertbutyl), optionally deuterated C1-6 alkoxy (e.g., optionally deuterated Cm alkoxy, such as methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), halogenated C1-6 alkyl (e.g., halogenated Cm alkyl, such as F3C-, FCH2-, F2CH-, CICH2-, CI2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2CICH2-), optionally substituted C3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), C2-6 alkenyl (e.g., vinyl, propenyl, or butenyl) or C2-6alkynyl (e.g., ethynyl, propynyl, or butynyl); and m represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4; wherein when R and Rs together with the carbon atom to which they are connected form a carbonyl group and Re represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4; with the proviso that the following compounds and compounds of Formula (I’) are excluded: 0 when A represents CH2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0; when A represents CH2 or C(O) and Ra represents H2N-CH2-, m represents an integer of 1 and n represents an integer of 0; when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; and the compounds of Formula (I’): 0 Formula (I’) wherein A represents CH2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

[0061] In some embodiments, the compounds of Formula (I) and their salts (including pharmaceutically acceptable salts, such as hydrochloride, etc.), prodrugs, solvates, isotopically enriched analogs, polymorphs, stereoisomers (including enantiomers and diastereomers), or mixture of stereoisomers thereof in Table 1 below are provided: Table 1. The compounds of the present disclosure Compo und No. Structure of compound Compound’s name Chinese translation of Compound’s name GT-03234 0 Br       O ° O 3 -(5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 ci 0 3 -(5-(chloromethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-(chloromethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 । 1^0° X—NH O 3 -(5-(iodomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-(iodomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione GT-03421 0 HO           (    ° 0 3 -(5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 HO JLJZ / n \ / =° H°---NH O 3-(6-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione GT-03445 ’k 0 3-(4-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione GT-03446 1 0 HO           ( O 3-(7-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-fluoro-5-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 1 0 O 3-(5-(aminomethyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(aminomethyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 H N ll / N \ )=0 O 3-(5-(aminomethyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(aminomethyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 F      O 3-(5-(aminomethyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(aminomethyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 T     Il      N—\ / =° O (2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl 4-methylbenzenesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl               4- methylbenzenesulfonate O mso^O1n~C1° 0 (2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl methanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl methanesulfonate o T„ 1O ° o (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl trifluoromethanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl trifluoromethanesulfonate 1 ° Br                      ° \ NH 0 3-(5-(bromomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-(bromomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 .rUQC"^pr° 3-(5-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione o _ T I N“( / =0 VNH 0 3-(5-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione Br o Br                      ° VnH 0 3-(7-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o Br J JL / \ / =° o 3-(6-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 Br WO° Br      0 3-(4-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-bromo-5-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 3-(5-((3,6- diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((3,6- diazabicyclo [3.1.1 ]heptan-3-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione o 0 3-(5-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-l- oxoisoindolin-2-yl)piperidine-2,6-dione o 0 3-(5-((3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o "O5U“ 0 3-(5-((3,8- diazabicyclo [3.2.1 ]octan-3 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((3,8- diazabicyclo [3.2.1 ]octan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o o' 3-(5-((2,5- diazabicyclo[2.2. l]heptan-2-yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((2,5- diazabicyclo[2.2. l]heptan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione o o 3-(5-((2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione D D D        0 DO         0 3-(1 -oxo-5-((piperazin-1 -yl- 2,2,3,3,5,5,6,6- <7s)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-5-((piperazin-1 -yl-2,2,3,3,5,5,6,6-<7s)methyl)isoindolin-2-yl)piperidine-2,6-dione o "9006^ 3-(5-((2,6- dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((2,6-dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o 3-(5-((3,5-      . dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((3,5-      . dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 1 ° hO^Xn<^° A—NH o 3 -(7-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(7-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 1 0 0 3 -(7-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(7-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione Br o hOuCXn<^° O 3-(7-bromo-l-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(7-bromo-l-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 "OjQ3^>° 3 -(4-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(4-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 "OXd"^ Cl       0 3 -(4-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(4-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 Br      0 3-(4-bromo-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(4-bromo-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione p \- nh O 3 -(6-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(6-fluoro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione & t—Z z—' T 3 -(6-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(6-chloro-1 -oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione o HGB^03<>° \-NH o 3-(6-bromo-l-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(6-bromo-l-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 L N \ / =° NH 1         0 Br 3 -(4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 L JL^n \ / =° ^^^7  \— NH 1          O cr 3 -(4-(chloromethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-(chloromethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o [pH / ° \— NH 1         O 3 -(4-(iodomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-(iodomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 N \ / 0 ^^^7  \— NH J 0 HO 3 -(4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o 1 N \ 7=0 F^X^^7 Z^NH J ° HO 3-(5-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 F^^J^ / —\ 1 I \ / 0 ^^^7 V NH J      0 HO 3-(6-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione a O^zx L \= / o I 3-(7-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-fluoro-4-(hydroxymethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione O X ZZ^n \ 7=0 \— NH J ° h2n 3-(4-(aminomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(aminomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 Fx / ^^X / ~\ J £ N—( >0 Vnh 1          0 h2n 3-(4-(aminomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(aminomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione ZE z / =\ ■" X7"0 o 3-(4-(aminomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(aminomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 qZhx ° ^nh TsO^ (2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindo lin-4-yl)methyl 4-methylbenzenesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl               4- methylbenzenesulfonate o 11 n \ 7=0 1          O MsO (2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindo lin-4-yl)methyl methanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl methanesulfonate 0 f          / =° / —NH 1        0 TfO (2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindo lin-4-yl)methyl trifluoromethanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl trifluoromethanesulfonate 1 o Y^7 , / NH Br 3-(4-(bromomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(bromomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 jf   N—( / =0 F^Y^7 VNH 1          0 Br 3-(4-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 / --\ L 1 NA / 0 Y^7 Vnh 1          0 Br 3-(4-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione Br o Zx5x^° pH Br 3-(7-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 BrX^5>Y / -\ T JZ n \ 7=0 Y^7 pNH ]         0 Br 3-(6-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione °<xzx m 3-(5-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-bromo-4-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 ^^1^7 V NH 0 3-(4-((3,6- diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((3,6- diazabicyclo [3.1.1 ]heptan-3-yl)methyl)-l- oxoisoindolin-2-yl)piperidine-2,6-dione °^Zx rL \= /  Z-A z I 3-(4-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione p r vn \ ^^^-7 Vnh 0 rvN HN.^ 3-(4-((3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione X Z—A z / =\ vyY o 3-(4-((3,8- diazabicyclo [3.2.1 ]octan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((3,8- diazabicyclo [3.2.1 ]octan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione X Z—< z / =\ IO o 3-(4-((2,5- diazabicyclo[2.2. l]heptan-2-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((2,5- diazabicyclo[2.2. l]heptan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione X Z—V ^z / =\ <z^o o 3-(4-((2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione dA^NX HN^^-D dXdd 3-(1 -oxo-4-((piperazin-1 -yl- 2,2,3,3,5,5,6,6- <7s)methyl)isoindolin-2- yl)piperidine-2,6-dione 3-(1 -oxo-4-((piperazin-1 -yl-2,2,3,3,5,5,6,6-<7s)methyl)isoindolin-2-yl)piperidine-2,6-dione o U L N \ / ° 1 ^^^7    NH 1 J       0 HN^A^ 3-(4-((2,6- dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((2,6- dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 NH HN^ 3-(4-((3,5-      . dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((3,5-      . dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 1 ° y z'n \ / =° ^NH J       0 <4M HN^J 3-(7-fluoro-l-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(7-fluoro-l-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione a o u z n \ / =° ^^^7 A- NH _ J      0 ^^N HN^^ 3 -(7-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(7-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione Br o f L N \ / =° ^^^7 A- NH _    1        0 ^^N HN^^J 3-(7-bromo-l-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(7-bromo-l-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 j L'N \ / =° F^^^7 X-NH J 0 HN.___J 3 -(5-fluoro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(5-fluoro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 1 Z^ \ a^^-7 Vnh _ I          0 HN^X 3 -(5-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(5-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 J Z N \ / ° Br^^"7 )-NH J      0 HN.___J 3-(5-bromo-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(5-bromo-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione z z—< '^Z  [=\ VX / V o 3 -(6-fluoro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(6-fluoro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 / --\ T X N \ / =° ^^^7 ^-NH . J       0 <^N HN^X 3 -(6-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(6-chloro-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 0 .—. I Z N \ )=° \-nh . J      o ^N HN^ 3 -(6-bromo-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(6-bromo-1 -oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione O Br^MN 5=° 0 3 -(6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione Br\ 1      ° X ZT^n \ / =° ^^^7  \—NH O 3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 0 „xQjCd"^>° 0 3-(5-(((R)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(((R)-3-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 0 3-(5-(((S)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(((S)-3-. aminopiperidin-1 - yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o' 3 -(5-((4-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-((4-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o HNrJ 3J^nXX° o 3-(1 -oxo-5-(piperidin-4-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-5-(piperidin-4-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione o hnZJ V£ / n v^° o 3 -(5-(azetidin-3 -ylmethyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3 -(5-(azetidin-3 -ylmethyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione p Z Z^N \ / =° ^^^7  , / NH . J      0 nh2 3-(4-(((R)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-(((R)-3-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 Z Z N \ / =° ^S^^7  \- NH 3 nh2 3-(4-(((S)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-(((S)-3-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 [[     N—( >0 V NH .    1          0 H2N^^ 3 -(4-((4-aminopiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione3 -(1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione 3 -(4-((4-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione3-(1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione HN"A C10n \ / =° ^NH 0 0 3 -(4-(azetidin-3 -ylmethyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3 -(4-(azetidin-3 -ylmethyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione p =uO^"-Qr° 0 0 5-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 । Jl JL / N VNH 0 0 2-(2,6-dioxopiperidin-3 -yl)-5-(iodomethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-(iodomethyl)isoindo line-1,3-dione 0 HO                 ° V NH 0 0 2-(2,6-dioxopiperidin-3-yl)- 5- (hydroxymethyl)isoindo line- 1,3-dione 2-(2,6-dioxopiperidin-3 -yl)- 5- (hydroxymethyl)isoindoline -1,3-dione 0 m«^Qv^Qt° fL 0 0 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-5- (hydroxymethyl)isoindoline -1,3-dione 0 / ---v HO 1 X / N \ / =° VNH 0 0 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-6- (hydroxymethyl)isoindoline -1,3-dione 1 ° „oJU^“-Qr» 0 0 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-6- (hydroxymethyl)isoindoline -1,3-dione 0 p   0 0 5 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 5 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 0 0 0 5 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 5 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione I N) z o^z^o X o 6 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 6 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 0 Ts° 0 0 (2-(2,6-dioxopiperidin-3-yl)- 1,3 -dioxoisoindo lin-5- yl)methyl               4- methylbenzenesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl               4- methylbenzenesulfonate 0 ms°x^0^N^1-^° 0 0 (2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-5-yl)methyl methanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl methanesulfonate 0 0 0 (2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-5-yl)methyl trifluoromethanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl trifluoromethanesulfonate 1 0 — [11^N \ / =° 0 o 6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 0 Br |L o o 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione o Br I JZ / N \ )=° o o 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione Br 0 0 0 4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione a. O^z~^o M 00 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 „ [l N \ / =0 yNH Br 0 0 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione o o o 5-((3,6- diazabicyclo [3.1.1 ]heptan-3 - yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((3,6- diazabicyclo [3.1.1 ]heptan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 0 0 5-((3,6- diazabicyclo [3.1.1 ]heptan-6- yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 X- NH 0 0 5-((3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((3,8- diazabicyclo[3.2.1]octan-8- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione o o o 5-((3,8- diazabicyclo [3.2.1 ]octan-3 - yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 5-((3,8- diazabicyclo [3.2.1 ]octan-3 - yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione p o o 5-((2,5- diazabicyclo[2.2. l]heptan-2- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 5-((2,5- diazabicyclo[2.2. l]heptan- 2-yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 0 0 5-((2,5- diazabicyclo[2.2.2]octan-2- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 5-((2,5- diazabicyclo[2.2.2]octan-2- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione D D _        0 2-(2,6-dioxopiperidin-3 -yl)-5-((piperazin-1 -yl-2,2,3,3,5,5,6,6- <7x [methyl [isoindo 1 ine-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-((piperazin-1 -yl-2,2,3,3,5,5,6,6- <7x [methyl [isoindo 1 ine-1,3-dione 0 HN00O5^Z^° 1               0 0 5-((2,6-dimethylpiperazin-1 -yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((2,6-dimethylpiperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione X-NH 0 0 5-((3,5-dimethylpiperazin-1 - yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 5-((3,5-dimethylpiperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 1 / ° HO \— NH O O 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-6-(piperazin-1 -ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione 1 ° uaH> 0 o 4-chloro-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 4-chloro-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione I y^Z Z ' y< ” o^z^o ’ri o 4-bromo-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 4-bromo-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione p hO^O^n<^° F   0 o 2-(2,6-dioxopiperidin-3-yl)-4 - fluoro -5 - (pip erazin-1 -ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-5-(piperazin-l-ylmethyl)isoindoline-1,3-dione 0 ■axH> Cl ° ° 4-chloro-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1- ylmethyl)isoindoline-1,3-dione 4-chloro-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1- ylmethyl)isoindoline-1,3-dione o ■oXx Br ° ° 4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1- ylmethyl)isoindoline-1,3-dione 4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1- ylmethyl)isoindoline-1,3-dione o "QXdX^0 ----------            \—NH o o 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione xok>” o o 5-chloro-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 5-chloro-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 0 0 0 5-bromo-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 5-bromo-2-(2,6-dioxopiperidin-3 -yl)-6-(piperazin-1- ylmethyl)isoindoline-1,3-dione 0 j^n— / )=° NH J 0 o cr 4-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione p (1 N \ / =° ^~nh J o o r 2-(2,6-dioxopiperidin-3 -yl)-4-(iodomethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-(iodomethyl)isoindo line-1,3-dione 0 OvX° 1 0 0 HO 2-(2,6-dioxopiperidin-3-yl)- 4- (hydroxymethyl)isoindo line- 1,3-dione 2-(2,6-dioxopiperidin-3 -yl)- 4- (hydroxymethyl)isoindoline -1,3-dione X o / ^X MJ O^Z^O o 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-4- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-4- (hydroxymethyl)isoindoline -1,3-dione 0 HO 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-4- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-4- (hydroxymethyl)isoindoline -1,3-dione f 0 J 0 0 HO 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7- (hydroxymethyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-7- (hydroxymethyl)isoindoline -1,3-dione 0 r jyn—( )=o F>VY YNH J 0 0 h2n 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione o Fx / ^^, y-v T L N \ / ° nh J 0 0 h2n 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione h2n 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione 4 - (aminomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione 0 TsO (2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-4- yl)methyl                4- methylbenzenesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl               4- methylbenzenesulfonate 0 9^Y° MsO (2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-4-yl)methyl methanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl methanesulfonate 0 9^° TfO (2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-4-yl)methyl tri fluoromethanesulfonate (2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl tri fluoromethanesulfonate f o Br 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione 0 |f JYnY )=o fYY Ynh I 0 0 Br 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione 0 / ---\ 1 L N \ / =° ^-nh J 0 0 Br 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione Br o L JL^N \ / =° Y NH J O O Br 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione o Br^^^^'  .—. T j7 n \ / =° ^nh J o o Br 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 Jl lOn \ / =° )^NH Loo Br 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione o r i"n \ / =° NH _ J O O n 4-((3,6- diazabicyclo [3.1.1 ]heptan-3 -y l)methy 1)-2 - (2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((3,6- diazabicyclo [3.1.1 ]heptan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 ruN Hn£>I 4-((3,6- diazabicyclo [3.1.1 ]heptan-6- yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((3,6- diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 |j       —( / =0 >7 NH J o 0 H^N 4-((3,8- diazabicyclo[3.2.1]octan-8- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 4-((3,8- diazabicyclo[3.2.1]octan-8- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione p r n \ / =° ff nh . J O 0 <N 4-((3,8- diazabicyclo [3.2.1 ]octan-3 - yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((3,8- diazabicyclo [3.2.1 ]octan-3 - yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 0 r £^n \ / =° / 7 NH J oo £) 4-((2,5- diazabicyclo[2.2. l]heptan-2- yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((2,5- diazabicyclo[2.2. l]heptan- 2-yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione p [[ jZ^N \ / =° NH J 0 0 X? 4-((2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((2,5- diazabicyclo[2.2.2]octan-2- yl)methyl)-2-(2,6- dioxopiperidin-3- yl)isoindoline-1,3 -dione 0 11 Z'N \ / =° D        XNH D V 1    0 0 D-y N HNs^-D D D D 2-(2,6-dioxopiperidin-3-yl)-4-((piperazin-1 -yl- 2,2,3,3,5,5,6,6- <7s)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((piperazin-1 -yl-2,2,3,3,5,5,6,6- <78)methyl)isoindoline-1,3-dione 0 IT'N \ / =° । tvI ynh 1 j oo r i 4-((2,6-dimethylpiperazin-1 -yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((2,6 -dimethy Ipip erazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 r n \ / =° >7 NH .    J oo N hn^£ 4-((3,5-dimethylpiperazin-1 -yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((3,5-dimethylpiperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione F 0 ^N HN^ 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(piperazin-1 -ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4 - fluoro -7 - (pip erazin-1 -ylmethyl)isoindoline-1,3-dione Cl 0 <^N HN^ 4-chloro-2-(2,6-dioxopiperidin-3 -yl)-7 -(piperazin-1-ylmethyl)isoindoline-1,3-dione 4-chloro-2-(2,6-dioxopiperidin-3 -yl)-7 -(piperazin-1-ylmethyl)isoindoline-1,3-dione ?r 0 hn^£ 4-bromo-2-(2,6-dioxopiperidin-3 -yl)-7 -(piperazin-1- ylmethyl)isoindoline-1,3-dione 4-bromo-2-(2,6-dioxopiperidin-3 -yl)-7 -(piperazin-1- ylmethyl)isoindoline-1,3-dione 0 1 jl'N \ / =° Vnh _ J 0 0 < N HN^J 2-(2,6-dioxopiperidin-3-yl)-5 - fluoro -4 - (pip erazin-1 -ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5 - fluoro -4 - (pip erazin-1 -ylmethyl)isoindoline-1,3-dione 0 £   N—\ / =° >-NH . J 0 0 < N HN^ 5-chloro-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 5-chloro-2-(2,6-dioxopiperidin-3 -yl)-4- (piperazin-1- ylmethyl)isoindoline-1,3-dione X Z—\ / \ ? \—z / =\ o^z^o "h o 5-bromo-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 5-bromo-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione I z—. Z f=\ V o 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-4-(piperazin-1 -ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-6 - fluoro -4 - (pip erazin-1 -ylmethyl)isoindoline-1,3-dione o .—. L L N \ / =° T^v! ^NH . J O 0 p N HN^£ 6-chloro-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 6-chloro-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 0 T L N \ / =° # NH . J 0 0 p N 6-bromo-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 6-bromo-2-(2,6-dioxopiperidin-3 -yl)-4-(piperazin-1- ylmethyl)isoindoline-1,3-dione 0 H2N"'CnxJ0^N^ }H 0 0 0 5-(((R)-3 -aminopiperidin-1 - yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-(((R)-3-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 f£ jC5 h2n^—N         Vnh 0 0 5-(((S)-3-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-(((S)-3-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 H2NpN jPX^nX ^ ° 0 0 5-((4-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 HNQjOdN<>o 0 0 2-(2,6-dioxopiperidin-3 -yl)-5-(piperazin-l- ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-(piperazin-l- ylmethyl)isoindoline-1,3-dione p o hn jr U^N \ ^0 o 2-(2,6-dioxopiperidin-3 -yl)-5-(piperidin-4- ylmethyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-(piperidin-4- ylmethyl)isoindoline-1,3-dione 0 0 / -NH m J UK / \ / ^° 0 5-(azetidin-3 -y Imethy 1) -2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-(azetidin-3 -y Imethy 1) -2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione p f    N—( / =° ^-NH * J 0 0 < N nh2 4-(((R)-3 -aminopiperidin-1 - yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-(((R)-3-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 r jl'n\ / ^° ^nh j °° 9 nh2 4-(((S)-3 -aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-(((S)-3-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 4-((4-aminopiperidin-1 -yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4-aminopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione z _z {YV o=^z^o o 4-(azetidin-3 -y Imethy 1) -2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-(azetidin-3 -y Imethy 1) -2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione X o 1 k r o (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid o fTN-( / =° \—Mn i          ° O          N hoA^n^J (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid 0 « ojOAA0 0 0 (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid OyZyO Zy^ ~ 4 X (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid (E)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid 0 HO^Q n3b>° o 3-(5-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 n \ / =° ^~nh _     1          0 r^N HO^^N^ 3-(4-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione X o^ 0 b O^Z^O ‘1? o 2-(2,6-dioxopiperidin-3-yl)-5-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)isoindoline-1,3-dione Cl. O^^O \AA \—z o I 2-(2,6-dioxopiperidin-3-yl)-4-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-(3- hydro xypropyl)piperazin-1 -yl)methyl)isoindoline-1,3-dione 0 *"nxo30> o' 3-(5-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-(3-bromopropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 rjT*1 \ / =° , ^nh -     1           0 3-(4-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-(3-bromopropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione ? 0 b 0^2^0 ■y o 5-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 p^N 4-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4-(3- bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione o Xi^aH^ o' 3-(5-((4-hydroxypiperidin-l-yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-hydroxypiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione p ( x n \ / =° NH . 1         o HO^^ 3 -(4-((4-hydroxypiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-hydroxypiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione XuoR^ o o 2-(2,6-dioxopiperidin-3-yl)-5-((4-hydroxypiperidin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-hydroxypiperidin-1 -yl)methyl)isoindoline-1,3-dione o r xn-c / =° y-nh J o ° p N HO^^ 2-(2,6-dioxopiperidin-3-yl)-4-((4-hydroxypiperidin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-hydroxypiperidin-1 -yl)methyl)isoindoline-1,3-dione O xwH> o 3 -(5-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3 -(5-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 f X'N \ / =° A— NH _ J       0 p^N 3 -(4-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3 -(4-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 Brx^^           / \ I J XJXnX '° 0 0 5-((4-bromopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4-bromopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 [j          \ / =° -7 NH _  1 oo < N 4-((4-bromopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4-bromopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione o n IXnX ^° Br^^ X- NH O 3-(5-(((2-                 . bromoethyl)(methyl)amino) methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-(((2-                 . bromoethyl)(methyl)amino) methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione i. {y-^ \ — m 3-(4-(((2- bromoethyl)(methyl)amino) methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(((2- bromoethyl)(methyl)amino) methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 . N >-NH 0 O 5-(((2-                    . bromoethyl)(methyl)amino) methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-(((2-                    . bromoethyl)(methyl)amino) methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 n \ / =° ^NH ° ° 1 4-(((2- bromoethyl)(methyl)amino) methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-(((2- bromoethyl)(methyl)amino) methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 k ',i o 3-(5-((methyl(piperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-((methyl(piperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o N \ / =° HN^     ' ^-NH L 1 J       o 1 3-(4-((methyl(piperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((methyl(piperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 N IXX^0 HN^       0 0 2-(2,6-dioxopiperidin-3 -yl)-5-((methyl(piperidin-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((methyl(piperidin-4-yl)amino)methyl)isoindolin e-1,3-dione O XN —( )=o HN^      XNH L 1 J o o N 1 2-(2,6-dioxopiperidin-3 -yl)-4-((methyl(piperidin-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((methyl(piperidin-4-yl)amino)methyl)isoindolin e-1,3-dione HN^         o 0 3-(1 -oxo-5-((4-(piperazin-1 -yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-5-((4-(piperazin-l-yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione I z—< z b „ <z>=o o 3-(1 -oxo-4-((4-(piperazin-1 -yl)piperidin-l- yl)methyl)isoindolin-2- yl)piperidine-2,6-dione 3-(1 -oxo-4-((4-(piperazin-l-yl)piperidin-l- yl)methyl)isoindolin-2-yl)piperidine-2,6-dione HN^         O o o 2-(2,6-dioxopiperidin-3-yl)-5-((4-(piperazin-l-yl)piperidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-((4-(piperazin-1 -yl)piperidin-l- yl)methyl)isoindoline-1,3-dione <^N HN___J 2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperazin-1 -yl)piperidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperazin-1 -yl)piperidin-l- yl)methyl)isoindoline-1,3-dione I 0 0 u. -o 3-(1 -oxo-5-((4-(piperidin-4-yl)piperazin-l- yl)methyl)isoindolin-2- yl)piperidine-2,6-dione 3-(1 -oxo-5-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione p [[      N—(  )=0 ^s^--7  X— NH .     1           0 <^N HN^J 3-(1 -oxo-4-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-4-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione HN^         0 0 0 2-(2,6-dioxopiperidin-3 -yl)-5-((4-(piperidin-4-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-(piperidin-4-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione HN^J 2-(2,6-dioxopiperidin-3 -yl)-4-((4-(piperidin-4-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperidin-4-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione 9 9 k x-0 3-(l-oxo-5-((4-phenylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-5-((4-phenylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 0 r n \ / ° Vnh . J       0 < N a«^ 3-(1-Oxo-4-((4-phenylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-4-((4-phenylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione d    p OjCXn<^° 0 0 2-(2,6-dioxopiperidin-3-yl)-5-((4-phenylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-phenylpiperazin-1 -yl)methyl)isoindoline-1,3-dione Q Z—1 z / =\ Hj o^z^o 1? o 2-(2,6-dioxopiperidin-3-yl)-4-((4-phenylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-phenylpiperazin-1 -yl)methyl)isoindoline-1,3-dione II                                  ° 0 3-(5-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione □0 b 0,., o 3-(4-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione T j             o ' OXX / Q0 0 0 5-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione CD b Z—1 ^Z / =\ ^“W o^z^o Tj o 4-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4-(4- bromophenyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione (N1 0 ' On 0 3-(1 -oxo-5-((4-(pyridazin-3 -yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-5-((4-(pyridazin-3-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 0 if Jdn \ / =° dNH 1          0 r^N 3-(1 -oxo-4-((4-(pyridazin-3 -yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-4-((4-(pyridazin-3-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione Cl       ° ^NH 0 0 2-(2,6-dioxopiperidin-3 -yl)-5-((4-(pyridazin-3-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-(pyridazin-3-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione Q 0^ vy? Y; o 2-(2,6-dioxopiperidin-3 -yl)-4-((4-(pyridazin-3-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-(pyridazin-3-yl)piperazin-l- yl)methyl)isoindoline-1,3-dione o 0 1, Yl o 3-(5-((4-(6-chloropyridazin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-(6- chloropyridazin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione o 0 o 3-(4-((4-(6-chloropyridazin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-(6-chloropyridazin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione o 0 o h 0^2^==0 °0 o 5-((4-(6-chloropyridazin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-((4-(6-chloropyridazin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione o [f 00N \ / =° 0NH -   \    O 0 p N N"NyN^ ci^55^ 4-((4-(6-chloropyridazin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-((4-(6-chloropyridazin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 "Xu^Hb 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5- yl)methyl)-3- fluoropiperidin-4-yl methanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate 0 c'Vn \ / =° /  \—NH 0 MsO^y F 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4- yl)methyl)-3- fluoropiperidin-4-yl methanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate 0 0 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5- yl)methyl)-3- fluoropiperidin-4-yl methanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin- 5-yl)methyl)-3- fluoropiperidin-4-yl methanesulfonate 0 If £^N \ / =° nh J 00 „0" F 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4- yl)methyl)-3- fluoropiperidin-4-yl methanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate 0Tf          o On jOJnCO 0 X-NH 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl)piperidin-3 -yl tri fluoromethanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl)piperidin-3 -yl tri fluoromethanesulfonate 0 O5<>o NH 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate 0Tf          o M jQ5<>o X-NH 0 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl)piperidin-3-yl trifluoromethanesulfonate 0 f vN \ k° y~NH TfO. / - J 0 0 1 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate I 0 o k o 3-(5-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 11 N \ / =° \- NH 1          O HaN'^^ 3-(4-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione H2N.,N. Il      / n3jOXn O ° s—A—NH 0 0 5-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 11      N—( / =° NH ___ \    O O < N HaN'^^ 4-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-((4-(6-aminopyridin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione HN''A                 O ----------            \- NH O 3-(5-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(5-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 r T N \ 1° VnH J     0 <^N p^n^J HN-J 3-(4-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione HN"A              O O nx>° O 0 5-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 1° T55*^     NH . J 0 0 p N HN-J 4-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-((4-(azetidin-3-yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione HN^^          O k^N         fA Xn A JL / n0 '° O 3-(1 -oxo-5-((3 -(piperazin-1 -yl)azetidin-l- yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-5-((3-(piperazin-l-yl)azetidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 0 L L N \ 1° \- NH J 0 pN ^N^7 HN^k 3-(1 -oxo-4-((3 -(piperazin-1 -yl)azetidin-l- yl)methyl)isoindolin-2- yl)piperidine-2,6-dione 3-(l-oxo-4-((3-(piperazin-l-yl)azetidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione HN^|           0 Xn 1Xn\>° >Nx / x^( \-NH 0 0 2-(2,6-dioxopiperidin-3 -yl)-5-((3-(piperazin-l-yl)azetidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((3-(piperazin-l-yl)azetidin-l- yl)methyl)isoindoline-1,3-dione 0 L X N \ / 0 A NH J 0 0 f-N HN^ 2-(2,6-dioxopiperidin-3 -yl)-4-((3-(piperazin-1 -yl)azetidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((3-(piperazin-1 -yl)azetidin-l-yl)methyl)isoindoline-1,3-dione 0 ^OxOXx. ^° \xN—VhlH o 3 -(5-((4-methylpiperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3 -(5-((4-methylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o f X n—< )=o A NH _ J       o 3 -(4-((4-methylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3 -(4-((4-methylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o GuOXn O ° X / N^ / X^x  X- NH o o 2-(2,6-dioxopiperidin-3-yl)-5-((4-methylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-methylpiperazin-1 -yl)methyl)isoindoline-1,3-dione o L X N \ ^° T^X A NH J 0 0 < N / N^X 2-(2,6-dioxopiperidin-3-yl)-4-((4-methylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-methylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 1 0 F cvo5x>° X^Nx / X^ ^NH 0 3-(5-((4-(difluoromethyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-((4- (difluoromethyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione o L X'N \ / =° \—NH J ° X'n F^N^X F 3-(4-((4-(difluoromethyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-((4- (difluoromethyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 0 u X' o 5-((4- (difluoromethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4- (difluoromethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 11 X N \ / =° V NH _ J 0 0 p N F^N^X F 4-((4- (difluoromethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4- (difluoromethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 n XX / XT^0 Z\ / N\ / XXX ^NH HN^        ° 3-(1 -oxo-5-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-5-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione 0 1 X^ \ / =° HN^       )-NH L 1 J       o v—^N H 3-(1 -oxo-4-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(1 -oxo-4-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione O . a XXXXIXo HN^       O O 2-(2,6-dioxopiperidin-3-yl)-5-((piperidin-4- ylamino)methyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-((piperidin-4- ylamino)methyl)isoindoline -1,3-dione 0 [J      n—( )=o HN^>       ^NH L 1 J oo — N H 2-(2,6-dioxopiperidin-3 -yl)-4-((piperidin-4- ylamino)methyl)isoindo line-1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-((piperidin-4- ylamino)methyl)isoindoline -1,3-dione 0 O / XnO>° ^NH O 3-(5-((4-(2- .      . aminoethyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-(2- .      . aminoethyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione X M z ? ^y) r o 3-(4-((4-(2-aminoethyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-(2-aminoethyl)piperazin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione o o o 5-((4-(2-     .      . aminoethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 5-((4-(2-     .      . aminoethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 90^° h2n^n— 4-((4-(2-aminoethyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4-((4-(2- aminoethyl)piperazin-1 - yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3 -dione 0 "XiXd^ 0 3-(l-oxo-5-((4-propylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-5-((4-propylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione o L Z N \ / ° Onh _ J       0 <^N 3-(1-Oxo-4-((4-propylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-4-((4-propylpiperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione O ''^'OTZZ O ° o o 2-(2,6-dioxopiperidin-3-yl)-5-((4-propylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-propylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 0 r   n—\ / =° ^~NH . 1    0 0 < N 2-(2,6-dioxopiperidin-3-yl)-4-((4-propylpiperazin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-propylpiperazin-1 -yl)methyl)isoindoline-1,3-dione O h ITZ O ° HO^^         >-NH 0 3-(5-(((2-         . hydroxyethyl)amino)methyl) -1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-(((2-         . hydroxyethyl)amino)methy 1)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 |[ Tn—( >o Vnh HQ ___ J      0 '^N H 3-(4-(((2-hydroxyethyl)amino)methyl) -1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-(((2- hydroxyethyl)amino)methy 1)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione O a Th ^° HO^---\ NH o o 2-(2,6-dioxopiperidin-3-yl)- 5-(((2-            . hydroxyethyl)amino)methyl) isoindoline-1,3 -dione 2-(2,6-dioxopiperidin-3-yl)- 5-(((2-            . hydroxyethyl)amino)methy l)isoindoline-1,3 -dione X o IZ / =\ v_w o^z^o o 2-(2,6-dioxopiperidin-3-yl)- 4-(((2- hydroxyethyl)amino)methyl) isoindoline-1,3 -dione 2-(2,6-dioxopiperidin-3-yl)-4-(((2- hydroxyethyl)amino)methy l)isoindoline-1,3 -dione o             o “YcaH^ oz 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl)piperidine-4-carboxylic acid 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-5-yl)methyl)piperidine-4-carboxylic acid p f I N \ / =° NH ho^n 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-d-y^methy^piperidine-d-carboxylic acid 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindo lin-4-yl)methyl)piperidine-4-carboxylic acid 0             o o o 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl)piperidine-4-carboxylic acid 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5 -y l)methy l)pip eridine -4 -carboxylic acid c%>° <^N H<W 0 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl)piperidine-4-carboxylic acid 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4 -y l)methy l)pip eridine-4-carboxylic acid o HO                    O o l'-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindo lin-5-yl)methyl)-[l,4'-bipiperidine]-4-carboxylic acid 1 '-((2-(2,6-dioxopiperidin- 3 -yl)-1 -oxoisoindo lin-5- yl)methyl)-[l,4'- bipiperidine]-4-carboxylic acid 0 fLN\ / ° NH -vO"'0 0 l'-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindo lin-4- yl)methyl)-[l,4'- bipiperidine]-4-carboxylic acid 1 '-((2-(2,6-dioxopiperidin- 3 -yl)-1 -oxoisoindo lin-4- yl)methyl)-[l,4'- bipiperidine]-4-carboxylic acid o o o l'-((2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-5-yl)methyl)-[l,4'-bipiperidine]-4-carboxylic acid 1 '-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-5-yl)methyl)-[l,4'- bipiperidine]-4-carboxylic acid 0 f    N \ / =0 ^~NH 0 0 < N H 0 l'-((2-(2,6-dioxopiperidin-3-yl)-1,3 -dioxoisoindo lin-4-yl)methyl)-[l,4'-bipiperidine]-4-carboxylic acid 1 '-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindo lin-4-yl)methyl)-[l,4'- bipiperidine]-4-carboxylic acid O o 3 -(5-((4-ethynylpiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(5-((4-ethynylpiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 0 11 L'N \ / =° ^^^7 A—NH _ J       O K^n 3 -(4-((4-ethynylpiperidin-1 -yl)methyl)-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(4-((4-ethynylpiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione . 0 u I£n O ° X-NH 0 0 2-(2,6-dioxopiperidin-3-yl)-5-((4-ethynylpiperidin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((4-ethynylpiperidin-1 -yl)methyl)isoindoline-1,3-dione 0 11 L N \ / 0 \— NH . J o o p N 2-(2,6-dioxopiperidin-3-yl)-4-((4-ethynylpiperidin-1 -yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((4-ethynylpiperidin-1 -yl)methyl)isoindoline-1,3-dione 0 HN^           0 3-(1 -oxo-5-((3 -(piperazin-1 -yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-5-((3-(piperazin-l-yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione o J X'N—< / 0 HN^          )-NH ° 3-(1 -oxo-4-((3 -(piperazin-1 -yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione 3-(l-oxo-4-((3-(piperazin-l-yl)piperidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione I Z—t ^b b P o 2-(2,6-dioxopiperidin-3 -yl)-5-((3-(piperazin-l-yl)piperidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-((3-(piperazin-l-yl)piperidin-l- yl)methyl)isoindoline-1,3-dione 0 111^N XT0 HN^   T1 )~NH 00 2-(2,6-dioxopiperidin-3 -yl)-4-((3-(piperazin-1 -yl)piperidin-l- yl)methyl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-((3-(piperazin-1 -yl)piperidin-l-yl)methyl)isoindoline-1,3-dione o h bbbb ° / y_ NH HN___J              ° 3-(5-(((4-methylpiperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(((4-methylpiperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 F iT^n \ / =° HN^         ), NH H 3-(4-(((4-methylpiperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-(((4-methylpiperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione O i Id bbbN^Tb^° ^bN \— NH HN^J        O O 2-(2,6-dioxopiperidin-3 -yl)-5-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3-yl)-5-(((4-methylpiperidin-4-yl)amino)methyl)isoindolin e-1,3-dione I b zz / =\ vy? o^z^o r o 2-(2,6-dioxopiperidin-3 -yl)-4-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-(((4-methylpiperidin-4-yl)amino)methyl)isoindolin e-1,3-dione N              0 ^jObpr0 3-(5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 [f £n—( >0 Vnh 1         0 HN__ 'NH o-' 3-(4-(((3 -methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-(((3 -methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione o \   ) ZI h o^z^o o 2-(2,6-dioxopiperidin-3 -yl)-5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4- yl)amino)methyl)isoindolin e-1,3-dione 0 r iT^n \ / =° ^nh J 0 o HN __ ^zA / ^NH o—' 2-(2,6-dioxopiperidin-3 -yl)-4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline -1,3-dione 2-(2,6-dioxopiperidin-3 -yl)-4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindolin e-1,3-dione 0 «Xxbpr° 0 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindo line-5-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindo line-5-carbaldehyde b •p o 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindo line-5-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindo line-5-carbaldehyde 1 0 Ox / XN \ ^° X—NH 0 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindo line-5-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindo line-5-carbaldehyde 0 jf jXN—( >0 \_NH J o cr 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-1 -oxoisoindo line-4-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-l -oxoisoindo line-4-carbaldehyde o T X N \ / ° ^^^7  X— NH J      o 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindo line-4-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindo line-4-carbaldehyde f o ^j^7 ^-NH 0^     ° 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindoline-4-carbaldehyde 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindo line-4-carbaldehyde o o^ / Oun7Z^° F   O O 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-l,3- dioxoisoindoline-5-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-l,3- dioxoisoindoline-5-carbaldehyde O F^^^f / —\ o^X JXN \ / ° X— NH O O 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-l,3- dioxoisoindoline-5-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-l,3- dioxoisoindoline-5-carbaldehyde 1 ° o^ XXn ( x° X-NH 0 0 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l,3- dioxoisoindoline-5-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l,3- dioxoisoindoline-5-carbaldehyde 0 F^"pr° ox 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-l,3- dioxoisoindoline-4-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-5-fluoro-l,3- dioxoisoindoline-4-carbaldehyde o FyUI 11 1 N \ / =° ^NH J o o 0^ 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-l,3- dioxoisoindoline-4-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-l,3- dioxoisoindoline-4-carbaldehyde f 0 cr 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l,3- dioxoisoindoline-4-carbaldehyde 2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l,3- dioxoisoindoline-4-carbaldehyde GT-03419 0 0 / N7 r II n—< )=o Br 3-(4-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 0 7NH r ii n7 >=o \-- / 3-(5-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione Br o O Br^^v7 / N7 r I|n^ )=o 3-(7-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-bromo-6-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 0 0 “7X57>" F 3-(6-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(6-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 0 °\ r |i n—< >=0 F^^^7 '— / 3-(6-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(6-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 00 Sb Sr o 3-(6-(bromomethyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-(bromomethyl)-7-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione Z~O m 3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione Br\ I p o z“NH LtyN V^0 Br 3-(4-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(4-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione Br\ | p o zAyX V—NH I Ji N—( 5=0 3-(5-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(5-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione Br\ 1 p o y—nh r jr n~6 >=o 3-(6-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione 3-(6-bromo-7-(bromomethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione Br\ I p o / “NH LLn^J=o F 3-(7-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(7-(bromomethyl)-4-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione Br\ y-NH I JT N—( 5=0 3-(7-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(7-(bromomethyl)-5-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione Br\ I p o y—NH 3-(7-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione 3-(7-(bromomethyl)-6-fluoro-1 -oxoisoindo lin-2-yl)piperidine-2,6-dione p o Br^^rX / N<_ r li n—<   >=o Br ° 4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 0 °\ Br^r^vX >-NH r II n—< >=o Br^^7!^  '—' 0 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione ?r o o ^-NH XjCn v?° 0 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione p o Br^^yA / N\L r li n—<   y=o F © 6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 6-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione O °\ Br^r^rX FNH r ii n—< >=o O 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione F o o Br^rArX FN" r li n—< 5=o 0 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione 5-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)-4-fluoroisoindoline-1,3 -dione clrp> 0 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3 -dione 00 ?-O^ O^z^O o 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione Br^ I p o y—nh [ IT N —(   >=O Br''^5^^     '—' o 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione z^Q m / m 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-7 -fluoroisoindoline-1,3 -dione I p o y-NH L I N -( >0 O 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3 -yl)-6-fluoroisoindoline-1,3 -dione ___ / 1 CD q_7 o^z^o o 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione 4 - (bromomethy 1) -2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3 -dione Compounds of Formula (II)

[0062] The present disclosure provides a compound of Formula (II) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof: PBM-Rf-LIN-ULM Formula (II) wherein PBM, Rf, LIN and ULM are as defined in the compounds of Formula (II) above.

[0063] The compound of Formula (II) of the present disclosure does not comprise the following compounds: 3 -(4-((3 -(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-<f|pyrimidin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difhiorobenzyl)-lH-indazol-3-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-l,3- dioxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difhiorobenzyl)-lH-indazol-3-yl)-4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-3- oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-l H-indazol-3-yl)-4-(4-(l-((2-(2,6-dioxopiperi din-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-l H-indazol-3-yl)-4-(4-(l-((2-(2,6-dioxopiperi din-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-l H-indazol-3-yl)-4-(4-(l-((2-(2,6-dioxopiperi din-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-lH-indazol-3-yl)-4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-l-yl)imidazo[ 1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)methyl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperidin-3-yl)-5-((3-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-l-yl)imidazo[ 1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)isoindoline-1,3-dione.

[0064] The compound of Formula (II) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotope enriched analogues, prodrugs, or polymorphs thereof of the present disclosure can bind to target proteins, recruit target proteins to E3 ubiquitin ligases for ubiquitination labeling and degradation. The compound of Formula (II) of the present disclosure can specifically target specific type or family of target protein, and exhibit a wide range of pharmacological activities by degrading / inhibiting diverse types or families of target proteins.

[0065] In some embodiments, specific target protein includes, but is not limited to, the target proteins in Table 2: Table 2. Applicable specific target proteins abbreviation of     target protein target protein’s name Chinese translation of target protein’s name Cas9 CRISPR-associated endonuclease Cas9 CRISPR-associated endonuclease Cas9 SHP2 Src homology 2 domain containing protein tyrosine phosphatase Src homology 2 domain containing protein tyrosine phosphatase ER Estrogen receptor Estrogen receptor AR Androgen receptor Androgen receptor BTK Bruton tyrosine kinase Bruton tyrosine kinase IRAK4 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase 4 EGFR Epidermal growth factor receptor Epidermal growth factor receptor MET Hepatocyte growth factor receptor Hepatocyte growth factor receptor KIT Mast / stem cell growth factor receptor Kit Mast / stem cell growth factor receptor Kit EPHA2 Ephrin type-A receptor 2 Ephrin type-A receptor 2 PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D SRC Proto-oncogene tyrosine-protein kinase Src Proto-oncogene tyrosine-protein kinase Src BRAF Serine / threonine-protein kinase B-raf Serine / threonine-protein kinase B-raf FGFR (fibroblast growth factor receptors,FGFRs) (fibroblast growth factor receptors,FGFRs) FGFR2 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 2 FGFR1 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 1 LYN Tyrosine-protein kinase Lyn Tyrosine-protein kinase Lyn ITK Tyrosine-protein kinase ITK / TSK Tyrosine-protein kinase ITK / TSK PARP1 Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 1 HDAC2 Histone deacetylase 2 Histone deacetylase 2 HDAC3 Histone deacetylase 3 Histone deacetylase 3 JAKI Tyrosine-protein kinase JAKI Tyrosine-protein kinase JAKI BCL2 Apoptosis regulator Bcl-2 Apoptosis regulator Bcl-2 HDAC6 Histone deacetylase 6 Histone deacetylase 6 CRBN Protein cereblon Protein cereblon EPHB2 Ephrin type-B receptor 2 Ephrin type-B receptor 2 BLK Tyrosine-protein kinase Blk Tyrosine-protein kinase Blk HDAC1 Histone deacetylase 1 Histone deacetylase 1 IGF1R Insulin-like growth factor 1 receptor Insulin-like growth factor 1 receptor TGFBR1 TGF-beta receptor type-1 TGF-beta receptor type-1 AKT2 RAC-beta serine / threonine-protein kinase RAC-beta serine / threonine-protein kinase AKT1 RAC-alpha serine / threonine-protein kinase RAC-alpha serine / threonine-protein kinase FAK Focal adhesion kinase Focal adhesion kinase MAPK1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 1 MAPK14 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 14 CDK9 Cyclin-dependent kinase 9 Cyclin-dependent kinase 9 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Induced myeloid leukemia cell differentiation protein Mcl-1 BET Bromodomain and extra-terminal domain protein Bromodomain and extra-terminal domain protein BRD4 Bromodomain-containing protein 4 Bromodomain-containing protein 4 BRD3 Bromodomain-containing protein 3 Bromodomain-containing protein 3 CDK13 Cyclin-dependent kinase 13 Cyclin-dependent kinase 13 BCL2L1 Bcl-2-like protein 1 Bcl-2-like protein 1 CDK12 Cyclin-dependent kinase 12 Cyclin-dependent kinase 12 CDK1 Cyclin-dependent kinase 1 Cyclin-dependent kinase 1 AKT3 RAC-gamma serine / threonine-protein kinase RAC-gamma serine / threonine-protein kinase CDK11B Cyclin-dependent kinase 1 IB Cyclin-dependent kinase 11B PAK4 Serine / threonine-protein kinase PAK 4 Serine / threonine-protein kinase PAK 4 MAPKAPK2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 2 TNK2 Activated CDC42 kinase 1 Activated CDC42 kinase 1 SIRT2 NAD-dependent protein deacetylase sirtuin-2 NAD-dependent protein deacetylase sirtuin-2 DAPK1 Death-associated protein kinase 1 Death-associated protein kinase 1 ABL2 Tyrosine-protein kinase ABL2 Tyrosine-protein kinase ABL2 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 KAT2A Histone acetyltransferase KAT2A Histone acetyltransferase KAT2A PBRM1 Protein polybromo-1 Protein polybromo-1 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase Interferon-induced, double-stranded RNA-activated protein kinase MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Mitogen-activated protein kinase kinase kinase 7 MAPT Microtubule-associated protein tau Microtubule-associated protein tau RIPK1 Receptor-interacting serine / threonine-protein kinase 1 Receptor-interacting serine / threonine-protein kinase 1 IRAKI Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 1 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase kinase 1 MARK4 MAP / microtubule affinity-regulating kinase 4 MAP / microtubule affinity-regulating kinase 4 BRD9 Bromodomain-containing protein 9 Bromodomain-containing protein 9 RIPK2 Receptor-interacting serine / threonine-protein kinase 2 Receptor-interacting serine / threonine-protein kinase 2 LIMK1 LIM domain kinase 1 LIM domain kinase 1 STK38 Serine / threonine-protein kinase 38 Serine / threonine-protein kinase 38 TRIM24 Transcription intermediary factor 1-alpha Transcription intermediary factor 1-alpha SMARCA4 Transcription activator BRG1 Transcription activator BRG1 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 TBK1 Serine / threonine-protein kinase TBK1 Serine / threonine-protein kinase TBK1 KRAS GTPase KRas GTPase KRas SMARCA2 Probable global transcription activator SNF2L2 Probable global transcription activator SNF2L2 PCNA Proliferating cell nuclear antigen Proliferating cell nuclear antigen BRD7 Bromodomain-containing protein 7 Bromodomain-containing protein 7 SUZI 2 Polycomb protein SUZI2 Polycomb protein SUZ12 IKZF1 DNA-binding protein Ikaros DNA-binding protein Ikaros HTT Huntingtin Huntingtin SNCA Alpha-synuclein Alpha-synuclein SLC9A1 Sodium / hydrogen exchanger 1 Sodium / hydrogen exchanger 1 FER Tyrosine-protein kinase Fer Tyrosine-protein kinase Fer MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Mitogen-activated protein kinase kinase kinase kinase 2 DLG4 Disks large homolog 4 Disks large homolog 4 IKZF3 Zinc finger protein Aiolos Zinc finger protein Aiolos PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A HMGCR 3 -hydroxy-3 -methylglutaryl-coenzyme    A reductase 3 -hydroxy-3 -methylglutaryl-coenzyme    A reductase ABL1 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase ABL 1 RARA Retinoic acid receptor alpha Retinoic acid receptor alpha FLT3 Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein kinase FLT3 RARG Retinoic acid receptor gamma Retinoic acid receptor gamma VEGFR-1 Vascular endothelial growth factor receptor 1 Vascular endothelial growth factor receptor 1 EZH2 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase EZH2 EPHA1 Ephrin type-A receptor 1 Ephrin type-A receptor 1 AURKA Aurora kinase A Aurora kinase A CHEK1 Serine / threonine-protein kinase Chkl Serine / threonine-protein kinase Chkl WEE1 Wee 1-like protein kinase Wee 1-like protein kinase PLK1 Serine / threonine-protein kinase PLK1 Serine / threonine-protein kinase PLK1 CDC7 Cell division cycle 7-related protein kinase Cell division cycle 7-related protein kinase AURKB Aurora kinase B Aurora kinase B PLK4 Serine / threonine-protein kinase PLK4 Serine / threonine-protein kinase PLK4 MDM2 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase Mdm2 MAPK6 Mitogen-activated protein kinase 6 Mitogen-activated protein kinase 6 BUB1 Mitotic checkpoint serine / threonine-protein kinase BUB 1 Mitotic checkpoint serine / threonine-protein kinase BUB 1 ESRRA Steroid hormone receptor ERR1 Steroid hormone receptor ERR1 BCL6 B-cell lymphoma 6 protein B-cell lymphoma 6 protein MAPK12 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 12 CRABP2 Cellular retinoic acid-binding protein 2 Cellular retinoic acid-binding protein 2 HIPK1 Homeodomain-interacting protein kinase 1 Homeodomain-interacting protein kinase 1 ADRM1 Proteasomal ubiquitin receptor ADRM1 Proteasomal ubiquitin receptor ADRM1 CDC20 Cell division cycle protein 20 homolog Cell division cycle protein 20 homolog BUB IB Mitotic checkpoint serine / threonine-protein kinase BUB 1 beta Mitotic checkpoint serine / threonine-protein kinase BUB 1 beta NTRK2 BDNF / NT-3 growth factors receptor BDNF / NT-3 growth factors receptor NTRK1 High affinity nerve growth factor receptor High affinity nerve growth factor receptor CD274 Programmed cell death 1 ligand 1 Programmed cell death 1 ligand 1 NUAK1 NUAK family SNFl-like kinase 1 NUAK family SNFl-like kinase 1 PDCD1 Programmed cell death protein 1 Programmed cell death protein 1 ERBB2 Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-2 EPHA3 Ephrin type-A receptor 3 Ephrin type-A receptor 3 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 LCK Tyrosine-protein kinase Lek Tyrosine-protein kinase Lek MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Dual specificity mitogen-activated protein kinase kinase 2 JAK3 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase JAK3 GSK3B Glycogen synthase kinase-3 beta Glycogen synthase kinase-3 beta JAK2 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK2 PRKCI Protein kinase C iota type Protein kinase C iota type FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A DHODH Dihydroorotate dehydrogenase Dihydroorotate dehydrogenase PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CDK6 Cyclin-dependent kinase 6 Cyclin-dependent kinase 6 CDK4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B FYN Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn TYK2 Non-receptor tyrosine-protein kinase TYK2 Non-receptor tyro sine-protein kinase TYK2 PDK1 Pyruvate dehydrogenase 1 Pyruvate dehydrogenase 1 PDK2 Pyruvate dehydrogenase 2 Pyruvate dehydrogenase 2 PDK3 Pyruvate dehydrogenase 3 Pyruvate dehydrogenase 3 YES1 Tyrosine-protein kinase Yes Tyrosine-protein kinase Yes GSK3A Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 alpha CDK16 Cyclin-dependent kinase 16 Cyclin-dependent kinase 16 CSNK2A1 Casein kinase II subunit alpha Casein kinase II subunit alpha CDK7 Cyclin-dependent kinase 7 Cyclin-dependent kinase 7 PTK2B Protein-tyrosine kinase 2-beta Protein-tyrosine kinase 2-beta MAPK10 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 10 MAPK9 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase 9 MAPK8 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 8 CDK5 Cyclin-dependent-like kinase 5 Cyclin-dependent-like kinase 5 METAP2 Methionine aminopeptidase 2 Methionine aminopeptidase 2 BRD2 Bromodomain-containing protein 2 Bromodomain-containing protein 2 MAPK3 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 3 TEC Tyrosine-protein kinase Tec Tyrosine-protein kinase Tec CDK14 Cyclin-dependent kinase 14 Cyclin-dependent kinase 14 CDK17 Cyclin-dependent kinase 17 Cyclin-dependent kinase 17 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 Mitogen-activated protein kinase kinase kinase 11 RPS6KB1 Ribosomal protein S6 kinase beta-1 Ribosomal protein S6 kinase beta-1 CSK Tyrosine-protein kinase CSK Tyrosine-protein kinase CSK MERTK Tyrosine-protein kinase Mer Tyrosine-protein kinase Mer STK17B Serine / threonine-protein kinase 17B Serine / threonine-protein kinase 17B CSNK2A2 Casein kinase II subunit alpha' Casein kinase II subunit alpha' RPS6KA1 Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-1 MAPK13 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 13 GAK Cyclin-G-associated kinase Cyclin-G-associated kinase CLK1 Dual specificity protein kinase CLK1 Dual specificity protein kinase CLK1 STK4 Serine / threonine-protein kinase 4 Serine / threonine-protein kinase 4 EIF4E Eukaryotic translation initiation factor 4E Eukaryotic translation initiation factor 4E STK10 Serine / threonine-protein kinase 10 Serine / threonine-protein kinase 10 LRRK2 Leucine-rich repeat serine / threonine-protein kinase 2 Leucine-rich repeat serine / threonine-protein kinase 2 TAOK3 Serine / threonine-protein kinase TAO3 Serine / threonine-protein kinase TAO3 MARK2 Serine / threonine-protein kinase MARK2 Serine / threonine-protein kinase MARK2 CSNK1D Casein kinase I isoform delta Casein kinase I isoform delta AAK1 AP2-associated protein kinase 1 AP2-associated protein kinase 1 IRAK3 Interleukin-1 receptor-associated kinase 3 Interleukin-1 receptor-associated kinase 3 STAT3 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 3 CAMKK1 Calcium / calmodulin-dependent protein kinase kinase 1 Calcium / calmodulin-dependent      protein kinase kinase 1 EED Polycomb protein EED Polycomb protein EED CSNK1A1 Casein kinase I isoform alpha Casein kinase I isoform alpha NEK1 Serine / threonine-protein kinase Nekl Serine / threonine-protein kinase Nekl BMP2K BMP-2-inducible protein kinase BMP-2-inducible protein kinase MAPK7 Mitogen-activated protein kinase 7 Mitogen-activated protein kinase 7 ULK1 Serine / threonine-protein kinase ULK1 Serine / threonine-protein kinase ULK1 RPS6KA3 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-3 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 11 LIMK2 LIM domain kinase 2 LIM domain kinase 2 CSNK1E Casein kinase I isoform epsilon Casein kinase I isoform epsilon EIF2AK4 eIF-2-alpha kinase GCN2 eIF-2-alpha kinase GCN2 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 Dual specificity mitogen-activated protein kinase kinase 5 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Mitogen-activated protein kinase kinase kinase kinase 3 VHL von Hippel-Lindau disease tumor suppressor von Hippel-Lindau disease tumor suppressor MARK3 MAP / microtubule affinity-regulating kinase 3 MAP / microtubule affinity-regulating kinase 3 TAOK2 Serine / threonine-protein kinase TAO2 Serine / threonine-protein kinase TAO2 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase kinase 5 SNRK SNF-related serine / threonine-protein kinase SNF-related serine / threonine-protein kinase EEF2K Eukaryotic elongation factor 2 kinase Eukaryotic elongation factor 2 kinase SGK3 Serine / threonine-protein kinase Sgk3 Serine / threonine-protein kinase Sgk3 AHR Aryl hydrocarbon receptor Aryl hydrocarbon receptor NEK4 Serine / threonine-protein kinase Nek4 Serine / threonine-protein kinase Nek4 NEK9 Serine / threonine-protein kinase Nek9 Serine / threonine-protein kinase Nek9 CIT Citron Rho-interacting kinase Citron Rho-interacting kinase LATS1 Serine / threonine-protein kinase LATS1 Serine / threonine-protein kinase LATS1 MINK1 Misshapen-like kinase 1 Misshapen-like kinase 1 SIK3 Serine / threonine-protein kinase SIK3 Serine / threonine-protein kinase SIK3 RPS6KA4 Ribosomal protein S6 kinase alpha-4 Ribosomal protein S6 kinase alpha-4 NEK3 Serine / threonine-protein kinase Nek3 Serine / threonine-protein kinase Nek3 SIK2 Serine / threonine-protein kinase SIK2 Serine / threonine-protein kinase SIK2 MAST3 Microtubule-associated     serine / threonine- protein kinase 3 Microtubule-associated serine / threonine-protein kinase 3 STK32C Serine / threonine-protein kinase 32C Serine / threonine-protein kinase 32C ALK ALK tyrosine kinase receptor ALK tyrosine kinase receptor ALK2 (activin receptor-like kinase 2,ALK2) (activin receptor-like kinase 2,ALK2) EPHB4 Ephrin type-B receptor 4 Ephrin type-B receptor 4 PARP2 Poly (ADP-ribose) polymerase 2 Poly (ADP-ribose) polymerase 2 PTK6 Protein-tyrosine kinase 6 Protein-tyrosine kinase 6 PARP3 Protein mono-ADP-ribosyltransferase PARP3 Protein       mono-ADP-ribosyltransferase PARP3 CDK2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 CDK8 Cyclin-dependent kinase 8 Cyclin-dependent kinase 8 BRDT Bromodomain testis-specific protein Bromodomain testis-specific protein MAPKAPK5 MAP kinase-activated protein kinase 5 MAP kinase-activated protein kinase 5 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 CDK18 Cyclin-dependent kinase 18 Cyclin-dependent kinase 18 CDK10 Cyclin-dependent kinase 10 Cyclin-dependent kinase 10 TTK Dual specificity protein kinase TTK Dual specificity protein kinase TTK PIM2 Serine / threonine-protein kinase pim-2 Serine / threonine-protein kinase pim-2 PKMYT1 Membrane-associated tyrosine- and threoninespecific cdc2-inhibitory kinase Membrane-associated     tyrosine-     and threonine-specific cdc2-inhibitory kinase MKNK2 MAP kinase-interacting serine / threonine-protein kinase 2 MAP kinase-interacting serine / threonine-protein kinase 2 KAT2B Histone acetyltransferase KAT2B Histone acetyltransferase KAT2B NEK2 Serine / threonine-protein kinase Nek2 Serine / threonine-protein kinase Nek2 HASPIN Serine / threonine-protein kinase haspin Serine / threonine-protein kinase haspin PIR Pirin Pirin CYP1B1 Cytochrome P450 1B1 Cytochrome P450 1B1 ERN1 Serine / threonine-protein kinase / endoribonuclease IREI S erine / thr eonine -protein kinase / endoribonuclease IREI MELK Maternal embryonic leucine zipper kinase Maternal embryonic leucine zipper kinase C0Q8A Atypical kinase COQ8A, mitochondrial Atypical kinase COQ8A, mitochondrial RI0K2 Serine / threonine-protein kinase RIO2 Serine / threonine-protein kinase RIO2 RPS6KA6 Ribosomal protein S6 kinase alpha-6 Ribosomal protein S6 kinase alpha-6 MAP3K20 Mitogen-activated protein kinase kinase kinase 20 Mitogen-activated protein kinase kinase kinase 20 MAPKAPK3 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 3 ULK3 Serine / threonine-protein kinase ULK3 Serine / threonine-protein kinase ULK3 MAP3K21 Mitogen-activated protein kinase kinase kinase 21 Mitogen-activated protein kinase kinase kinase 21 C0Q8B Atypical kinase COQ8B, mitochondrial Atypical kinase COQ8B, mitochondrial TNK1 Non-receptor tyrosine-protein kinase TNK1 Non-receptor tyro sine-protein kinase TNK1 BMPR1A Bone morphogenetic protein receptor type-1A Bone morphogenetic protein receptor type-1A STK17A Serine / threonine-protein kinase 17A Serine / threonine-protein kinase 17A CDK11A Cyclin-dependent kinase 11A Cyclin-dependent kinase 11A TESK2 Dual specificity testis-specific protein kinase 2 Dual specificity testis-specific protein kinase 2 NLK Serine / threonine-protein kinase NLK Serine / threonine-protein kinase NLK STK35 Serine / threonine-protein kinase 35 Serine / threonine-protein kinase 35 PKN3 Serine / threonine-protein kinase N3 Serine / threonine-protein kinase N3 STK33 Serine / threonine-protein kinase 33 Serine / threonine-protein kinase 33 SBK1 Serine / threonine-protein kinase SBK1 Serine / threonine-protein kinase SBK1 SLC9A2 Sodium / hydrogen exchanger 2 Sodium / hydrogen exchanger 2 CSNK2A3 Casein kinase II subunit alpha 3 Casein kinase II subunit alpha 3 TACC3 Transforming acidic coiled-coil-containing protein 3 Transforming acidic coiled-coil-containing protein 3 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Eukaryotic peptide chain release factor GTP-binding subunit ERF3A SLC9A7 Sodium / hydrogen exchanger 7 Sodium / hydrogen exchanger 7 RPS6KC1 Ribosomal protein S6 kinase delta-1 Ribosomal protein S6 kinase delta-1 TBCK TBC domain-containing protein kinase-like protein TBC domain-containing protein kinase-like protein CRABP1 Cellular retinoic acid-binding protein 1 Cellular retinoic acid-binding protein 1 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial TRPM7 Transient receptor potential cation channel subfamily M member 7 Transient receptor potential cation channel subfamily M member 7 TRIB3 Tribbles homolog 3 Tribbles homolog 3 UHMK1 Serine / threonine-protein kinase Kist Serine / threonine-protein kinase Kist PDIK1L Serine / threonine-protein kinase PDIK1L Serine / threonine-protein kinase PDIK1L STK40 Serine / threonine-protein kinase 40 Serine / threonine-protein kinase 40 SLC9A4 Sodium / hydrogen exchanger 4 Sodium / hydrogen exchanger 4 EPHB3 Ephrin type-B receptor 3 Ephrin type-B receptor 3 NTRK3 NT-3 growth factor receptor NT-3 growth factor receptor MAP3K12 Mitogen-activated protein kinase kinase kinase 12 Mitogen-activated protein kinase kinase kinase 12 MAPK11 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 11 DDR2 Discoidin domain-containing receptor 2 Discoidin domain-containing receptor 2 RARB Retinoic acid receptor beta Retinoic acid receptor beta PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C ID01 Indoleamine 2,3-dioxygenase 1 Indoleamine 2,3-dioxygenase 1 SLC9B1 Sodium / hydrogen exchanger 9B1 Sodium / hydrogen exchanger 9B1 PRAG1 Inactive tyro sine-protein kinase PRAG1 Inactive tyrosine-protein kinase PRAG1 TOPI DNA topoisomerase 1 DNA topoisomerase 1 TOP2A DNA topoisomerase 2-alpha DNA topoisomerase 2-alpha CXCR4 C-X-C chemokine receptor type 4 C-X-C chemokine receptor type 4 ERBB4 Receptor tyrosine-protein kinase erbB-4 Receptor tyrosine-protein kinase erbB-4 HCK Tyrosine-protein kinase HCK Tyrosine-protein kinase HCK SYK Tyrosine-protein kinase SYK Tyrosine-protein kinase SYK ACLY ATP-citrate synthase ATP-citrate synthase IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 Inosine-5'-monophosphate dehydrogenase 2 CYP3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 TOP2B DNA topoisomerase 2-beta DNA topoisomerase 2-beta KEAP1 Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1 NR3C1 Glucocorticoid receptor Glucocorticoid receptor DNMT1 DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 1 TXNRD1 Thioredoxin reductase 1, cytoplasmic Thioredoxin reductase 1, cytoplasmic HDAC4 Histone deacetylase 4 Histone deacetylase 4 PDGFRA Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor alpha TUBB Tubulin beta chain Tubulin beta chain TUBB2B Tubulin beta-2B chain Tubulin beta-2B chain GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 Gamma-aminobutyric acid receptor subunit alpha-5 EPHB1 Ephrin type-B receptor 1 Ephrin type-B receptor 1 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 2 GRIK2 Glutamate receptor ionotropic, kainate 2 Glutamate receptor ionotropic, kainate 2 CALM1 Calmodulin-1 Calmodulin-1 HDAC5 Histone deacetylase 5 Histone deacetylase 5 DNMT3A DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3A KIF5B Kinesin-1 heavy chain Kinesin-1 heavy chain POLDI DNA polymerase delta catalytic subunit DNA polymerase delta catalytic subunit CUL4A Cullin-4A Cullin-4A TUBB2A Tubulin beta-2A chain Tubulin beta-2A chain PDGFRB Platelet-derived growth factor receptor beta Platelet-derived growth factor receptor beta FGR Tyrosine-protein kinase Fgr Tyrosine-protein kinase Fgr PRKCG Protein kinase C gamma type Protein kinase C gamma type SCN3A Sodium channel protein type 3 subunit alpha Sodium channel protein type 3 subunit alpha HDAC9 Histone deacetylase 9 Histone deacetylase 9 BACE1 Beta-secretase 1 Beta-secretase 1 HSP90AA1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-alpha HSP90AB1 Heat shock protein HSP 90-beta Heat shock protein HSP 90-beta PDPK1 3-phosphoinositide-dependent protein kinase 1 3-phosphoinositide-dependent protein kinase 1 BIRC2 Baculoviral IAP repeat-containing protein 2 Baculoviral IAP repeat-containing protein 2 CHEK2 Serine / threonine-protein kinase Chk2 Serine / threonine-protein kinase Chk2 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase 5 CASP1 Caspase-1 Caspase-1 NAE1 NEDD8-activating enzyme El regulatory subunit NEDD8-activating enzyme El regulatory subunit PIK3R1 Phosphatidylinositol   3-kinase   regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit alpha IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit beta PSMA1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-1 ITGB1 Integrin beta-1 Integrin beta-1 PRKDC DNA-dependent protein kinase catalytic subunit DNA-dependent protein kinase catalytic subunit PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit beta FGF2 Fibroblast growth factor 2 Fibroblast growth factor 2 ZAP70 Tyrosine-protein kinase ZAP-70 Tyrosine-protein kinase ZAP-70 PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 beta GAPDH Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase FASN Fatty acid synthase Fatty acid synthase PKM Pyruvate kinase PKM Pyruvate kinase PKM VCP Transitional endoplasmic reticulum ATPase Transitional endoplasmic reticulum ATPase KDM1A Lysine-specific histone demethylase 1A Lysine-specific histone demethylase 1A TABI TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 EP300 Histone acetyltransferase p300 Histone acetyltransferase p300 VRK1 Serine / threonine-protein kinase VRK1 Serine / threonine-protein kinase VRK1 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Ribosomal protein S6 kinase alpha-5 UBA2 SUMO-activating enzyme subunit 2 SUMO-activating enzyme subunit 2 LDHA L-lactate dehydrogenase A chain L-lactate dehydrogenase A chain TKT Transketolase Transketolase HPRT1 Hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase KDM2A Lysine-specific demethylase 2A Lysine-specific demethylase 2A EHMT1 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT1 CAMKID Calcium / calmodulin-dependent protein kinase type ID Calcium / calmodulin-dependent      protein kinase type ID WDR5 WD repeat-containing protein 5 WD rep eat-containing protein 5 EHMT2 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EHMT2 RAC1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 OGT UDP-N-acetylglucosamine—peptide      N- acetylglucosaminyltransferase 110 kDa subunit UDP-N-acetylglucosamine—peptide     N- acetylglucosaminyltransferase 110 kDa subunit NCOA1 Nuclear receptor coactivator 1 Nuclear receptor coactivator 1 PHGDH D-3-phosphoglycerate dehydrogenase D-3-phosphoglycerate dehydrogenase ARHGDIA Rho GDP-dissociation inhibitor 1 Rho GDP-dissociation inhibitor 1 RBBP4 Histone-binding protein RBBP4 Histone-binding protein RBBP4 BPTF Nucleosome-remodeling factor subunit BPTF Nucleosome-remodeling factor subunit BPTF KAT5 Histone acetyltransferase KAT5 Histone acetyltransferase KAT5 NOTCH 1 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 1 PPIA Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 CREBBP CREB-binding protein CREB-binding protein POLB DNA polymerase beta DNA polymerase beta APEX1 DNA-(apurinic or apyrimidinic site) endonuclease DNA-(apurinic or apyrimidinic site) endonuclease CCNT1 Cyclin-Tl Cyclin-Tl EIF4A1 Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-I USP7 Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin carboxyl-terminal hydrolase 7 CTNNB1 Catenin beta-1 Catenin beta-1 TXN Thioredoxin Thioredoxin DDX3X ATP-dependent RNA helicase DDX3X ATP-dependent RNA helicase DDX3X NLRP3 NACHT, LRR and PYD domains-containing protein 3 NACHT, LRR and PYD domains-containing protein 3 TNKS Poly [ADP-ribose] polymerase tankyrase-1 Poly [ADP-ribose] polymerase tankyrase-1 PAK3 Serine / threonine-protein kinase PAK 3 Serine / threonine-protein kinase PAK 3 PKN1 Serine / threonine-protein kinase N1 Serine / threonine-protein kinase N1 CISDI CDGSH iron-sulfur domain-containing protein 1 CDGSH iron-sulfur domain-containing protein 1 WNK1 Serine / threonine-protein kinase WNK1 Serine / threonine-protein kinase WNK1 BRD1 Bromodomain-containing protein 1 Bromodomain-containing protein 1 XIAP E3 ubiquitin-protein ligase XIAP E3 ubiquitin-protein ligase XIAP PRDX1 Peroxiredoxin-1 Peroxiredoxin-1 KMT2A Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2A KDM5C Lysine-specific demethylase 5C Lysine-specific demethylase 5C RPA1 Replication protein A 70 kDa DNA-binding subunit Replication protein A 70 kDa DNA-binding subunit CAMK1 Calcium / calmodulin-dependent protein kinase type 1 Calcium / calmodulin-dependent      protein kinase type 1 EIF4A3 Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III TAF1 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 1 ALKBH3 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 Mitogen-activated protein kinase kinase kinase 2 RELA Transcription factor p65 Transcription factor p65 NCOR2 Nuclear receptor corepressor 2 Nuclear receptor corepressor 2 PRPF4B Serine / threonine-protein kinase PRP4 homolog Serine / threonine-protein kinase PRP4 homolog RPS3 40S ribosomal protein S3 40S ribosomal protein S3 RPSA 40S ribosomal protein SA 40S ribosomal protein SA RPS27A Ubiquitin-40S ribosomal protein S27a Ubiquitin-40S ribosomal protein S27a RPS20 40S ribosomal protein S20 40S ribosomal protein S20 RPL18 60S ribosomal protein L18 60S ribosomal protein L18 RPS5 40S ribosomal protein S5 40S ribosomal protein S5 RPL6 60S ribosomal protein L6 60S ribosomal protein L6 RPLPO 60S acidic ribosomal protein PO 60S acidic ribosomal protein PO RPL3 60S ribosomal protein L3 60S ribosomal protein L3 RPL18A 60S ribosomal protein LI8a 60S ribosomal protein LI8a RPL28 60S ribosomal protein L28 60S ribosomal protein L28 RPL19 60S ribosomal protein L19 60S ribosomal protein L19 RPL34 60S ribosomal protein L34 60S ribosomal protein L34 RPS13 40S ribosomal protein S13 40S ribosomal protein S13 RPL24 60S ribosomal protein L24 60S ribosomal protein L24 RPS15 40S ribosomal protein S15 40S ribosomal protein S15 RPL5 60S ribosomal protein L5 60S ribosomal protein L5 RPS1O 40S ribosomal protein S10 40S ribosomal protein S10 RPL35 60S ribosomal protein L35 60S ribosomal protein L35 RPS6 40S ribosomal protein S6 40S ribosomal protein S6 RPS24 40S ribosomal protein S24 40S ribosomal protein S24 RPS2 40S ribosomal protein S2 40S ribosomal protein S2 RPL11 60S ribosomal protein LI 1 60S ribosomal protein LI 1 RPS8 40S ribosomal protein S8 40S ribosomal protein S8 RPL32 60S ribosomal protein L32 60S ribosomal protein L32 RPS3A 40S ribosomal protein S3a 40S ribosomal protein S3a RPL10 60S ribosomal protein LIO 60S ribosomal protein LIO RPL7A 60S ribosomal protein L7a 60S ribosomal protein L7a RPL30 60S ribosomal protein L30 60S ribosomal protein L30 RPL8 60S ribosomal protein L8 60S ribosomal protein L8 RPL26 60S ribosomal protein L26 60S ribosomal protein L26 RPS14 40S ribosomal protein S14 40S ribosomal protein S14 RPL13 60S ribosomal protein L13 60S ribosomal protein L13 RPS9 40S ribosomal protein S9 40S ribosomal protein S9 RPS21 40S ribosomal protein S21 40S ribosomal protein S21 RPS7 40S ribosomal protein S7 40S ribosomal protein S7 RPL38 60S ribosomal protein L38 60S ribosomal protein L38 RPL4 60S ribosomal protein L4 60S ribosomal protein L4 RPL15 60S ribosomal protein L15 60S ribosomal protein L15 RPS17 40S ribosomal protein S17 40S ribosomal protein S17 RPS23 40S ribosomal protein S23 40S ribosomal protein S23 RPL14 60S ribosomal protein L14 60S ribosomal protein L14 RPL12 60S ribosomal protein L12 60S ribosomal protein L12 RPS4X 40S ribosomal protein S4, X isoform 40S ribosomal protein S4, X isoform RPL23A 60S ribosomal protein L23a 60S ribosomal protein L23a RPL10A 60S ribosomal protein L23a 60S ribosomal protein L23a RPS18 40S ribosomal protein S18 40S ribosomal protein S18 SLC7A5 Large neutral amino acids transporter small subunit 1 Large neutral amino acids transporter small subunit 1 ORAI1 Calcium release-activated calcium channel protein 1 Calcium release-activated calcium channel protein 1 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-alpha SUMO1 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 1 HSPA8 Heat shock cognate 71 kDa protein Heat shock cognate 71 kDa protein HSPD1 60 kDa heat shock protein, mitochondrial 60 kDa heat shock protein, mitochondrial CSNK2B Casein kinase II subunit beta Casein kinase II subunit beta PPP2CA Serine / threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine / threonine-protein phosphatase 2A catalytic subunit alpha isoform FSCN1 Fascin Fascin BID BH3-interacting domain death agonist BH3-interacting domain death agonist DCUN1D1 DCN1 -like protein 1 DCN 1-like protein 1 USP28 Ubiquitin carboxyl-terminal hydrolase 28 Ubiquitin carboxyl-terminal hydrolase 28 TP53BP1 TP53-binding protein 1 TP53-binding protein 1 KDM5A Lysine-specific demethylase 5A Lysine-specific demethylase 5A BAZ2A Bromodomain adjacent to zinc finger domain protein 2A Bromodomain adjacent to zinc finger domain protein 2A UBE2I SUMO-conjugating enzyme UBC9 SUMO-conjugating enzyme UBC9 SPIN1 Spindlin-1 Spindlin-1 TDP2 Tyrosyl-DNA phosphodiesterase 2 Tyrosyl-DNA phosphodiesterase 2 KDM5B Lysine-specific demethylase 5B Lysine-specific demethylase 5B RBBP5 Retinoblastoma-binding protein 5 Retinoblastoma-binding protein 5 PRMT1 Protein arginine N-methyltransferase 1 Protein arginine N-methyltransferase 1 MLLT1 Protein ENL Protein ENL SETDB1 Histone-lysine N-methyltransferase SETDB1 Histone-lysine N-methyltransferase SETDB1 ARNT Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor nuclear translocator SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase U5 small nuclear ribonucleoprotein 200 kDa helicase ATAD2 ATPase family AAA domain-containing protein 2 ATPase family AAA domain-containing protein 2 SQSTM1 Sequestosome-1 Sequestosome-1 DPY30 Protein dpy-30 homolog Protein dpy-30 homolog WRN Werner syndrome ATP-dependent helicase Werner syndrome ATP-dependent helicase JMJD1C Probable JmjC domain-containing histone demethylation protein 2C Probable JmjC domain-containing histone demethylation protein 2C MDM4 Protein Mdm4 Protein Mdm4 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 Lethal(3)malignant brain tumor-like protein 3 LDLR Low-density lipoprotein receptor Low-density lipoprotein receptor GLUL Glutamine synthetase Glutamine synthetase HRAS GTPase HRas GTPase HRas AP0BEC3G DNA dC->dU-editing enzyme APOBEC-3G DNA dC->dU-editing enzyme APOBEC-3G TSG101 Tumor susceptibility gene 101 protein Tumor susceptibility gene 101 protein LRP6 Low-density lipoprotein receptor-related protein 6 Low-density lipoprotein receptor-related protein 6 ENO1 Alpha-enolase Alpha-enolase ANXA2 Annexin A2 Annexin A2 SOD1 Superoxide dismutase [Cu-Zn] Superoxide dismutase [Cu-Zn] KAT6A Histone acetyltransferase KAT6A Histone acetyltransferase KAT6A CBS Cystathionine beta-synthase Cystathionine beta-synthase RUVBL1 RuvB-like 1 RuvB-like 1 UHRF1 E3 ubiquitin-protein ligase UHRF1 E3 ubiquitin-protein ligase UHRF1 HSPA5 Endoplasmic reticulum chaperone BiP Endoplasmic reticulum chaperone BiP SQLE Squalene monooxygenase Squalene monooxygenase NEDD4 E3 ubiquitin-protein ligase NEDD4 E3 ubiquitin-protein ligase NEDD4 RBBP7 Histone-binding protein RBBP7 Histone-binding protein RBBP7 UBE2N Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 N NRAS GTPase NRas GTPase NRas PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RHOA Transforming protein RhoA Transforming protein RhoA RNF31 E3 ubiquitin-protein ligase RNF31 E3 ubiquitin-protein ligase RNF31 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 TPI1 Triosephosphate isomerase Triosephosphate isomerase PPIG Peptidyl-prolyl cis-trans isomerase G Peptidyl-prolyl cis-trans isomerase G NCOA2 Nuclear receptor coactivator 2 Nuclear receptor coactivator 2 FOXO1 Forkhead box protein 01 Forkhead box protein 01 PSIP1 PC4 and SFRS1 -interacting protein PC4 and SFRS 1-interacting protein MACROD2 ADP-ribose glycohydrolase MACROD2 ADP-ribose glycohydrolase MACROD2 SETD2 Histone-lysine N-methyltransferase SETD2 Histone-lysine N-methyltransferase SETD2 NFKBIA NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha PLA2G4A Cytosolic phospholipase A2 Cytosolic phospholipase A2 IC AMI Intercellular adhesion molecule 1 Intercellular adhesion molecule 1 ACVR1B Activin receptor type-IB Activin receptor type-IB CYBB Cytochrome b-245 heavy chain Cytochrome b-245 heavy chain STAMBP STAM-binding protein STAM-binding protein NFKB1 Nuclear factor NF-kappa-B pl05 subunit Nuclear factor NF-kappa-B pl05 subunit PAK2 Serine / threonine-protein kinase PAK 2 Serine / threonine-protein kinase PAK 2 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate receptor type 1 ELAVL1 ELAV-like protein 1 ELAV-like protein 1 NFKB2 Nuclear factor NF-kappa-B pl00 subunit Nuclear factor NF-kappa-B pl00 subunit STAT1 Signal transducer and activator of transcription 1-alpha / beta Signal transducer and activator of transcription 1-alpha / beta STAT5A Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5A RIPK3 Receptor-interacting serine / threonine-protein kinase 3 Receptor-interacting serine / threonine-protein kinase 3 BRSK2 Serine / threonine-protein kinase BRSK2 Serine / threonine-protein kinase BRSK2 ERCC4 DNA repair endonuclease XPF DNA repair endonuclease XPF NPM1 Nucleophosmin Nucleophosmin IKBKG NF-kappa-B essential modulator NF-kappa-B essential modulator PBK Lymphokine-activated killer T-cell-originated protein kinase Lymphokine-activated killer T-cell-originated protein kinase CD22 B-cell receptor CD22 B-cell receptor CD22 APC Adenomatous polyposis coli protein Adenomatous polyposis coli protein PLCG1 1 -phosphatidylinositol      4,5-bisphosphate phosphodiesterase gamma-1 1 -phosphatidylinositol     4,5-bisphosphate phosphodiesterase gamma-1 ING2 Inhibitor of growth protein 2 Inhibitor of growth protein 2 ERCC1 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-1 KDM2B Lysine-specific demethylase 2B Lysine-specific demethylase 2B ETV6 Transcription factor ETV6 Transcription factor ETV6 CBX4 E3 SUMO-protein ligase CBX4 E3 SUMO-protein ligase CBX4 USP25 Ubiquitin carboxyl-terminal hydrolase 25 Ubiquitin carboxyl-terminal hydrolase 25 HSF1 Heat shock factor protein 1 Heat shock factor protein 1 TRIM33 E3 ubiquitin-protein ligase TRIM33 E3 ubiquitin-protein ligase TRIM33 HNRNPA1 Heterogeneous nuclear ribonucleoprotein Al Heterogeneous nuclear ribonucleoprotein Al TERF2 Telomeric repeat-binding factor 2 Telomeric repeat-binding factor 2 PTBP1 Polypyrimidine tract-binding protein 1 Polypyrimidine tract-binding protein 1 NR2C2 Nuclear receptor subfamily 2 group C member 2 Nuclear receptor subfamily 2 group C member 2 N0TCH2 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 2 USP8 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin carboxyl-terminal hydrolase 8 RGS12 Regulator of G-protein signaling 12 Regulator of G-protein signaling 12 ATF1 Cyclic AMP-dependent transcription factor ATF-1 Cyclic AMP-dependent transcription factor ATF-1 PPM IB Protein phosphatase IB Protein phosphatase IB PDCD4 Programmed cell death protein 4 Programmed cell death protein 4 LMNA Prelamin-A / C Prelamin-A / C MITF Microphthalmia-associated      transcription factor Microphthalmia-associated     transcription factor ADCY3 Adenylate cyclase type 3 Adenylate cyclase type 3 EEF1A1 Elongation factor 1-alpha 1 Elongation factor 1-alpha 1 MYH9 Myosin-9 Myosin-9 BCL3 B-cell lymphoma 3 protein B-cell lymphoma 3 protein XRCC5 X-ray repair cross-complementing protein 5 X-ray repair cross-complementing protein 5 USP4 Ubiquitin carboxyl-terminal hydrolase 4 Ubiquitin carboxyl-terminal hydrolase 4 AGL Glycogen debranching enzyme Glycogen debranching enzyme XRCC6 X-ray repair cross-complementing protein 6 X-ray repair cross-complementing protein 6 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 DVL1 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-1 VDAC2 Voltage-dependent anion-selective channel protein 2 Voltage-dependent anion-selective channel protein 2 MDH1 Malate dehydrogenase, cytoplasmic Malate dehydrogenase, cytoplasmic CBX5 Chromobox protein homolog 5 Chromobox protein homolog 5 USP10 Ubiquitin carboxyl-terminal hydrolase 10 Ubiquitin carboxyl-terminal hydrolase 10 CBX1 Chromobox protein homolog 1 Chromobox protein homolog 1 BRD8 Bromodomain-containing protein 8 Bromodomain-containing protein 8 TSNAX Translin-associated protein X Translin-associated protein X CREB1 Cyclic AMP-responsive element-binding protein 1 Cyclic AMP-responsive element-binding protein 1 RBCK1 RanBP-type and C3HC4-type zinc fingercontaining protein 1 RanBP-type and C3HC4-type zinc fingercontaining protein 1 UBA1 Ubiquitin-like modifier-activating enzyme 1 Ubiquitin-like modifier-activating enzyme 1 MACROD1 ADP-ribose glycohydrolase MACROD1 ADP-ribose glycohydrolase MACROD 1 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 Proline-, glutamic acid- and leucine-rich protein 1 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1 Ubiquitin carboxyl-terminal hydrolase BAP 1 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 Telomeric repeat-binding factor 2-interacting protein 1 LARP7 La-related protein 7 La-related protein 7 UBA7 Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like modifier-activating enzyme 7 SUMO3 Small ubiquitin-related modifier 3 Small ubiquitin-related modifier 3 SUMO2 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 2 GIGYF2 GRB10-interacting GYF protein 2 GRBlO-interacting GYF protein 2 S100A10 Protein S100-A10 Protein S100-A10 GRIK3 Glutamate receptor ionotropic, kainate 3 Glutamate receptor ionotropic, kainate 3 TLR8 Toll-like receptor 8 Toll-like receptor 8 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 NOS1 Nitric oxide synthase, brain Nitric oxide synthase, brain WNK3 Serine / threonine-protein kinase WNK3 Serine / threonine-protein kinase WNK3 TLR2 Toll-like receptor 2 Toll-like receptor 2 BCL2L11 Bcl-2-like protein 11 Bcl-2-like protein 11 SLC11A2 Natural resistance-associated macrophage protein 2 Natural resistance-associated macrophage protein 2 ABCB11 Bile salt export pump Bile salt export pump ITGAL Integrin alpha-L Integrin alpha-L ROCK1 Rho-associated protein kinase 1 Rho-associated protein kinase 1 CA12 Carbonic anhydrase 12 Carbonic anhydrase 12 EPHA7 Ephrin type-A receptor 7 Ephrin type-A receptor 7 PRKCA Protein kinase C alpha type Protein kinase C alpha type CA2 Carbonic anhydrase 2 Carbonic anhydrase 2 PDE2A cGMP-dependent                3',5'-cyclic phosphodiesterase cGMP-dependent               3',5'-cyclic phosphodiesterase EPHA4 Ephrin type-A receptor 4 Ephrin type-A receptor 4 ACE Angiotensin-converting enzyme Angiotensin-converting enzyme RAFI RAF proto-oncogene serine / threonine-protein kinase RAF proto-oncogene serine / threonine-protein kinase GLA Alpha-galactosidase A Alpha-galactosidase A MAOB Amine oxidase [flavin-containing] B Amine oxidase [flavin-containing] B AKR1B1 Aldo-keto reductase family 1 member B1 Aldo-keto reductase family 1 member B1 GSR Glutathione reductase, mitochondrial Glutathione reductase, mitochondrial UMPS Uridine 5'-monophosphate synthase Uridine 5'-monophosphate synthase THRA Thyroid hormone receptor alpha Thyroid hormone receptor alpha GART Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase Trifunctional purine biosynthetic protein adenosine-3                       [Includes: Phosphoribosylamine—glycine ligase FDPS Famesyl pyrophosphate synthase Famesyl pyrophosphate synthase ADH5 Alcohol dehydrogenase class-3 Alcohol dehydrogenase class-3 RXRB Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-beta DHFR Dihydrofolate reductase Dihydrofolate reductase PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Isocitrate     dehydrogenase      [NADP] cytoplasmic ITGB2 Integrin beta-2 Integrin beta-2 COMT Catechol O-methyltransferase Catechol O-methyltransferase PRKCQ Protein kinase C theta type Protein kinase C theta type IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 Inosine-5'-monophosphate dehydrogenase 1 HDAC7 Histone deacetylase 7 Histone deacetylase 7 TUBB3 Tubulin beta-3 chain Tubulin beta-3 chain TUBA 1A Tubulin alpha-1A chain Tubulin alpha-1A chain ADA Adenosine deaminase Adenosine deaminase GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 Gamma-aminobutyric acid receptor subunit gamma-2 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Gamma-aminobutyric acid type B receptor subunit 2 GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 Gamma-aminobutyric acid receptor subunit beta-2 GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 Gamma-aminobutyric acid receptor subunit beta-3 GABBR1 Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 1 PRKCE Protein kinase C epsilon type Protein kinase C epsilon type SIGMARI Sigma non-opioid intracellular receptor 1 Sigma non-opioid intracellular receptor 1 MTOR Serine / threonine-protein kinase mTOR Serine / threonine-protein kinase mTOR SLC29A1 Equilibrative nucleoside transporter 1 Equilibrative nucleoside transporter 1 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 ATP-sensitive inward rectifier potassium channel 11 GAA Lysosomal alpha-glucosidase Lysosomal alpha-glucosidase PRKCH Protein kinase C eta type Protein kinase C eta type PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform ROCK2 Rho-associated protein kinase 2 Rho-associated protein kinase 2 MAOA Amine oxidase [flavin-containing] A Amine oxidase [flavin-containing] A SOAT1 Sterol O-acyltransferase 1 Sterol O-acyltransferase 1 BCR Breakpoint cluster region protein Breakpoint cluster region protein PSMB5 Proteasome subunit beta type-5 Proteasome subunit beta type-5 XP01 Exportin-1 Exportin-1 MALT1 Mucosa-associated     lymphoid     tissue lymphoma translocation protein 1 Mucosa-associated     lymphoid     tissue lymphoma translocation protein 1 IDH2 Isocitrate     dehydrogenase      [NADP], mitochondrial Isocitrate     dehydrogenase     [NADP], mitochondrial RRM1 Ribonucleoside-diphosphate reductase large subunit Ribonucleoside-diphosphate reductase large subunit NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial EPHA5 Ephrin type-A receptor 5 Ephrin type-A receptor 5 TUBB4B Tubulin beta-4B chain Tubulin beta-4B chain TUBB1 Tubulin beta-1 chain Tubulin beta-1 chain TUBB4A Tubulin beta-4A chain Tubulin beta-4A chain TUBB6 Tubulin beta-6 chain Tubulin beta-6 chain TUBA4A Tubulin alpha-4A chain Tubulin alpha-4A chain TUBA IC Tubulin alpha-IC chain Tubulin alpha-IC chain CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-1 ATP1A2 Sodium / potassium-transporting     ATPase subunit alpha-2 Sodium / potassium-transporting     ATPase subunit alpha-2 ATP 1 A3 Sodium / potassium-transporting     ATPase subunit alpha-3 Sodium / potassium-transporting     ATPase subunit alpha-3 GRIA1 Glutamate receptor 1 Glutamate receptor 1 GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 Gamma-aminobutyric acid receptor subunit beta-1 ATP1A1 Sodium / potassium-transporting     ATPase subunit alpha-1 Sodium / potassium-transporting     ATPase subunit alpha-1 KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 Potassium voltage-gated channel subfamily KQT member 5 PRKCD Protein kinase C delta type Protein kinase C delta type CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H Voltage-dependent T-type calcium channel subunit alpha-1H GRIA4 Glutamate receptor 4 Glutamate receptor 4 KCNA3 Potassium voltage-gated channel subfamily A member 3 Potassium voltage-gated channel subfamily A member 3 S1PR3 Sphingosine 1-phosphate receptor 3 Sphingosine 1-phosphate receptor 3 NISCH Nischarin Nischarin PRKCB Protein kinase C beta type Protein kinase C beta type TLR7 Toll-like receptor 7 Toll-like receptor 7 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-IB Voltage-dependent N-type calcium channel subunit alpha-IB CACNA2D2 Voltage-dependent calcium channel subunit alpha-2 / delta-2 Voltage-dependent calcium channel subunit alpha-2 / delta-2 CPT2 Carnitine     O-palmitoyltransferase     2, mitochondrial Carnitine     O-palmitoyltransferase     2, mitochondrial FAAH Fatty-acid amide hydrolase 1 Fatty-acid amide hydrolase 1 UGCG Ceramide glucosyltransferase Ceramide glucosyltransferase PDE1A Calcium / calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Calcium / calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A HPD 4-hydroxyphenylpyruvate dioxygenase 4-hydroxyphenylpyruvate dioxygenase CA5B Carbonic anhydrase 5B, mitochondrial Carbonic anhydrase 5B, mitochondrial CA5A Carbonic anhydrase 5A, mitochondrial Carbonic anhydrase 5A, mitochondrial AN01 Anoctamin-1 Anoctamin-1 DHCR24 Delta(24)-sterol reductase Delta(24)-sterol reductase CCDC6 Coiled-coil domain-containing protein 6 Coiled-coil domain-containing protein 6 EML4 Echinoderm microtubule-associated proteinlike 4 Echinoderm microtubule-associated proteinlike 4 KCNA2 Potassium voltage-gated channel subfamily A member 2 Potassium voltage-gated channel subfamily A member 2 KCNB2 Potassium voltage-gated channel subfamily B member 2 Potassium voltage-gated channel subfamily B member 2 PLA2G7 Platelet-activating factor acetylhydrolase Platelet-activating factor acetylhydrolase GRM5 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor 5 PLA2G2A Phospholipase A2, membrane associated Phospholipase A2, membrane associated MIF Macrophage migration inhibitory factor Macrophage migration inhibitory factor GBA Lysosomal acid glucosylceramidase Lysosomal acid glucosylceramidase INSR Insulin receptor Insulin receptor GSTP1 Glutathione S-transferase P Glutathione S-transferase P PNP Purine nucleoside phosphorylase Purine nucleoside phosphorylase FDFT1 Squalene synthase Squalene synthase CASP8 Caspase-8 Caspase-8 CASP9 Caspase-9 Caspase-9 CASP6 Caspase-6 Caspase-6 CASP3 Caspase-3 Caspase-3 CASP7 Caspase-7 Caspase-7 ERAP1 Endoplasmic reticulum aminopeptidase 1 Endoplasmic reticulum aminopeptidase 1 UBA3 NEDD8-activating enzyme El catalytic subunit NEDD8-activating enzyme El catalytic subunit PSEN1 Presenilin-1 Presenilin-1 FNTA Protein famesyltransferase / geranylgeranyltransferase type-1 subunit alpha Protein famesyltransferase / geranylgeranyltransferase type-1 subunit alpha METAP1 Methionine aminopeptidase 1 Methionine aminopeptidase 1 CASP2 Caspase-2 Caspase-2 ITGA4 Integrin alpha-4 Integrin alpha-4 ABCB1 ATP-dependent translocase ABCB1 ATP-dependent translocase ABCB1 NTSR1 Neurotensin receptor type 1 Neurotensin receptor type 1 GRM3 Metabotropic glutamate receptor 3 Metabotropic glutamate receptor 3 LNPEP Leucyl-cystinyl aminopeptidase Leucyl-cystinyl aminopeptidase APH1A Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1A NCSTN Nicastrin Nicastrin PSMB1 Proteasome subunit beta type-1 Proteasome subunit beta type-1 PSMA2 Proteasome subunit alpha type-2 Proteasome subunit alpha type-2 PSMB7 Proteasome subunit beta type-7 Proteasome subunit beta type-7 PSMA5 Proteasome subunit alpha type-5 Proteasome subunit alpha type-5 PSMA4 Proteasome subunit alpha type-4 Proteasome subunit alpha type-4 PSMA3 Proteasome subunit alpha type-3 Proteasome subunit alpha type-3 PSMA6 Proteasome subunit alpha type-6 Proteasome subunit alpha type-6 PSMA7 Proteasome subunit alpha type-7 Proteasome subunit alpha type-7 PSMB2 Proteasome subunit beta type-2 Proteasome subunit beta type-2 EGLN1 Egl nine homolog 1 Egl nine homolog 1 PSMB6 Proteasome subunit beta type-6 Proteasome subunit beta type-6 PSMB4 Proteasome subunit beta type-4 Proteasome subunit beta type-4 PSMB8 Proteasome subunit beta type-8 Proteasome subunit beta type-8 PSMB10 Proteasome subunit beta type-10 Proteasome subunit beta type-10 PSMB9 Proteasome subunit beta type-9 Proteasome subunit beta type-9 FNTB Protein famesyltransferase subunit beta Protein famesyltransferase subunit beta PSMB3 Proteasome subunit beta type-3 Proteasome subunit beta type-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 Endoplasmic reticulum aminopeptidase 2 DNPEP Aspartyl aminopeptidase Aspartyl aminopeptidase STS Steryl-sulfatase Steryl-sulfatase SELL L-selectin L-selectin CCR1 C-C chemokine receptor type 1 C-C chemokine receptor type 1 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PORCN Protein-serine      O-palmitoleoyltransferase porcupine Protein-serine O-palmitoleoyltransferase porcupine P4HTM Transmembrane prolyl 4-hydroxylase Transmembrane prolyl 4-hydroxylase ATR Serine / threonine-protein kinase ATR Serine / threonine-protein kinase ATR CDK19 Cyclin-dependent kinase 19 Cyclin-dependent kinase 19 CDK3 Cyclin-dependent kinase 3 Cyclin-dependent kinase 3 CASP4 Caspase-4 Caspase-4 PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 5 CASP10 Caspase-10 Caspase-10 NPEPPS Puromycin-sensitive aminopeptidase Puromycin-sensitive aminopeptidase RNPEP Aminopeptidase B Aminopeptidase B LAP3 Cytosol aminopeptidase Cytosol aminopeptidase CDK20 Cyclin-dependent kinase 20 Cyclin-dependent kinase 20 DPYD Dihydropyrimidine          dehydrogenase [NADP(+)] Dihydropyrimidine         dehydrogenase [NADP(+)] XPNPEP1 Xaa-Pro aminopeptidase 1 Xaa-Pro aminopeptidase 1 NAMPT Nicotinamide phosphoribosyltransferase Nicotinamide phosphoribosyltransferase PRKACA cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit alpha PSMD14 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 14 ARAF Serine / threonine-protein kinase A-Raf Serine / threonine-protein kinase A-Raf PRKACB cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit beta ITGAV Integrin alpha-V Integrin alpha-V TGM2 Protein-glutamine                 gamma glutamyltransferase 2 Protein-glutamine                gamma glutamyltransferase 2 ACE2 Angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 PAK1 Serine / threonine-protein kinase PAK 1 Serine / threonine-protein kinase PAK 1 CAPN1 Calpain-1 catalytic subunit Calpain-1 catalytic subunit CDC42 Cell division control protein 42 homolog Cell division control protein 42 homolog NMT1 Glycylpeptide N-tetradecanoyltransferase 1 Glycylpeptide N-tetradecanoyltransferase 1 CAMK2D Calcium / calmodulin-dependent protein kinase type II subunit delta Calcium / calmodulin-dependent      protein kinase type II subunit delta AKR1B10 Aldo-keto reductase family 1 member BIO Aldo-keto reductase family 1 member BIO P4HB Protein disulfide-isomerase Protein disulfide-isomerase CDC42BPB Serine / threonine-protein kinase MRCK beta Serine / threonine-protein kinase MRCK beta CAMK2G Calcium / calmodulin-dependent protein kinase type II subunit gamma Calcium / calmodulin-dependent      protein kinase type II subunit gamma PTP4A1 Protein tyrosine phosphatase type IVA 1 Protein tyrosine phosphatase type IVA 1 G6PD Glucose-6-phosphate 1 -dehydrogenase Glucose-6-phosphate 1 -dehydrogenase LSS Lanosterol synthase Lanosterol synthase ALB Albumin Albumin ECE1 Endothelin-converting enzyme 1 Endothelin-converting enzyme 1 CTSD Cathepsin D Cathepsin D CTSB Cathepsin B Cathepsin B ILK Integrin-linked protein kinase Integrin-linked protein kinase MGLL Monoglyceride lipase Monoglyceride lipase CASK Peripheral plasma membrane protein CASK Peripheral plasma membrane protein CASK ADAM 17 Disintegrin and metalloproteinase domaincontaining protein 17 Disintegrin and metalloproteinase domaincontaining protein 17 PYGL Glycogen phosphorylase, liver form Glycogen phosphorylase, liver form ATIC Bifunctional purine biosynthesis protein ATIC Bifunctional purine biosynthesis protein ATIC HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 3-hydroxyacyl-CoA dehydrogenase type-2 SRPK1 SRSF protein kinase 1 SRSF protein kinase 1 LTA4H Leukotriene A-4 hydrolase Leukotriene A-4 hydrolase STK16 Serine / threonine-protein kinase 16 Serine / threonine-protein kinase 16 ADK Adenosine kinase Adenosine kinase GRK6 G protein-coupled receptor kinase 6 G protein-coupled receptor kinase 6 ACVR1 Activin receptor type-1 Activin receptor type-1 CES1 Liver carboxylesterase 1 Liver carboxylesterase 1 CSNK1G3 Casein kinase I isoform gamma-3 Casein kinase I isoform gamma-3 CYP51A1 Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase CAMK2A Calcium / calmodulin-dependent protein kinase type II subunit alpha Calcium / calmodulin-dependent      protein kinase type II subunit alpha BCAT1 Branched-chain-amino-acid aminotransferase, cytosolic Branched-chain-amino-acid aminotransferase, cytosolic MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 4 ACACB Acetyl-CoA carboxylase 2 Acetyl-CoA carboxylase 2 MTAP S-methyl-5'-thioadenosine phosphorylase S-methyl-5'-thioadenosine phosphorylase AHCY Adenosylhomocysteinase Adenosylhomocysteinase STK24 Serine / threonine-protein kinase 24 Serine / threonine-protein kinase 24 GALK1 Galactokinase Galactokinase MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 Dual specificity mitogen-activated protein kinase kinase 6 DCPS m7GpppX diphosphatase m7GpppX diphosphatase LDHB L-lactate dehydrogenase B chain L-lactate dehydrogenase B chain EPHX2 Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 NQ02 Ribosyldihydronicotinamide dehydrogenase [quinone] Ribosyldihydronicotinamide dehydrogenase [quinone] SRPK2 SRSF protein kinase 2 SRSF protein kinase 2 SAE1 SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1 CARMI Histone-arginine methyltransferase CARMI Histone-arginine methyltransferase CARMI CAMK4 Calcium / calmodulin-dependent protein kinase type IV Calcium / calmodulin-dependent      protein kinase type IV TNIK TRAF2 and NCK-interacting protein kinase TRAF2 and NCK-interacting protein kinase DCK Deoxycytidine kinase Deoxycytidine kinase PHKG2 Phosphorylase b kinase gamma catalytic chain, liver / testis isoform Phosphorylase b kinase gamma catalytic chain, liver / testis isoform DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A CBR1 Carbonyl reductase [NADPH] 1 Carbonyl reductase [NADPH] 1 DAPK3 Death-associated protein kinase 3 Death-associated protein kinase 3 FEN1 Flap endonuclease 1 Flap endonuclease 1 0XSR1 Serine / threonine-protein kinase OSR1 Serine / threonine-protein kinase OSR1 CLK3 Dual specificity protein kinase CLK3 Dual specificity protein kinase CLK3 UPP1 Uridine phosphorylase 1 Uridine phosphorylase 1 AKR1C1 Aldo-keto reductase family 1 member Cl Aldo-keto reductase family 1 member C1 AKR1C3 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C3 CD38 ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1 ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1 SORT1 Sortilin Sortilin GALNT2 Polypeptide                           N- acetylgalactosaminyltransferase 2 Polypeptide                            N- acetylgalactosaminyltransferase 2 LGALS1 Galectin-1 Galectin-1 HK2 Hexokinase-2 Hexokinase-2 HK1 Hexokinase-1 Hexokinase-1 HM0X1 Heme oxygenase 1 Heme oxygenase 1 PARP14 Protein        mono-ADP-ribosyltransferase PARP14 Protein       mono-ADP-ribosyltransferase PARP14 GRB2 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2 HM0X2 Heme oxygenase 2 Heme oxygenase 2 DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 N(G),N (G)-dimethylarginine dimethylaminohydrolase 1 PARP12 Protein        mono-ADP-ribosyltransferase PARP12 Protein       mono-ADP-ribosyltransferase PARP12 OAT Ornithine aminotransferase, mitochondrial Ornithine aminotransferase, mitochondrial SIRT6 NAD-dependent protein deacetylase sirtuin-6 NAD-dependent protein deacetylase sirtuin-6 PGK1 Phosphoglycerate kinase 1 Phosphoglycerate kinase 1 KAT8 Histone acetyltransferase KAT8 Histone acetyltransferase KAT8 SPR Sepiapterin reductase Sepiapterin reductase CTH Cystathionine gamma-lyase Cystathionine gamma-lyase SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent protein deacylase sirtuin-5, mitochondrial GST01 Glutathione S-transferase omega-1 Glutathione S-transferase omega-1 PFKFB3 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 3 CTBP2 C-terminal-binding protein 2 C-terminal-binding protein 2 P ARP 10 Protein        mono-ADP-ribosyltransferase PARP10 Protein       mono-ADP-ribosyltransferase P ARP 10 SMYD3 Histone-lysine N-methyltransferase SMYD3 Histone-lysine N-methyltransferase SMYD3 SULT1A1 Sulfotransferase 1A1 Sulfotransferase 1A1 AKR1C4 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member C4 GSTM2 Glutathione S-transferase Mu 2 Glutathione S-transferase Mu 2 STRADA STE20-related kinase adapter protein alpha STE20-related kinase adapter protein alpha BMPR2 Bone morphogenetic protein receptor type-2 Bone morphogenetic protein receptor type-2 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha PTPN1 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 1 IDE Insulin-degrading enzyme Insulin-degrading enzyme CAPNS1 Calpain small subunit 1 Calpain small subunit 1 GLO1 Lactoylglutathione lyase Lactoylglutathione lyase UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 NPC1 NPC intracellular cholesterol transporter 1 NPC intracellular cholesterol transporter 1 FES Tyrosine-protein kinase Fes / Fps Tyrosine-protein kinase Fes / Fps CSNK1G1 Casein kinase I iso form gamma-1 Casein kinase I isoform gamma-1 SLK STE20-like serine / threonine-protein kinase STE20-like serine / threonine-protein kinase MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Dual specificity mitogen-activated protein kinase kinase 7 PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase catalytic subunit type 3 HAO1 Hydroxyacid oxidase 1 Hydroxyacid oxidase 1 PASK PAS domain-containing serine / threonine-protein kinase PAS domain-containing serine / threonine-protein kinase STK25 Serine / threonine-protein kinase 25 Serine / threonine-protein kinase 25 KYNU Kynureninase Kynureninase DUT Deoxyuridine                 5'-triphosphate nucleotidohydrolase, mitochondrial Deoxyuridine                5'-triphosphate nucleotidohydrolase, mitochondrial PTPN22 Tyrosine-protein phosphatase non-receptor type 22 Tyrosine-protein phosphatase non-receptor type 22 NEK7 Serine / threonine-protein kinase Nek7 Serine / threonine-protein kinase Nek7 NNMT Nicotinamide N-methyltransferase Nicotinamide N-methyltransferase NRP1 Neuropilin-1 Neuropilin-1 RPS27 40S ribosomal protein S27 40S ribosomal protein S27 DDR1 Epithelial discoidin domain-containing receptor 1 Epithelial discoidin domain-containing receptor 1 LPL Lipoprotein lipase Lipoprotein lipase ABCC1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 ASIC1 Acid-sensing ion channel 1 Acid-sensing ion channel 1 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 1 PTPRS Receptor-type tyrosine-protein phosphatase S Receptor-type tyrosine-protein phosphatase S ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 SLC1A3 Excitatory amino acid transporter 1 Excitatory amino acid transporter 1 SLC1A1 Excitatory amino acid transporter 3 Excitatory amino acid transporter 3 TRPM2 Transient receptor potential cation channel subfamily M member 2 Transient receptor potential cation channel subfamily M member 2 GRM1 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor 1 MLKL Mixed lineage kinase domain-like protein Mixed lineage kinase domain-like protein RAB7A Ras-related protein Rab-7a Ras-related protein Rab-7a AHCYL1 S-adenosylhomocysteine      hydrolase-like protein 1 S-adenosylhomocysteine     hydrolase-like protein 1 NAAA N-acylethanolamine-hydro lyzing        acid amidase N-acylethanolamine-hydro lyzing       acid amidase CAMK2B Calcium / calmodulin-dependent protein kinase type II subunit beta Calcium / calmodulin-dependent      protein kinase type II subunit beta NT5E 5'-nucleotidase 5'-nucleotidase CTSL Procathepsin L Pro cathepsin L HSPA1A Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1A FABP5 Fatty acid-binding protein 5 Fatty acid-binding protein 5 CTSC Dipeptidyl peptidase 1 Dipeptidyl peptidase 1 ACVR2A Activin receptor type-2A Activin receptor type-2A MMP14 Matrix metalloproteinase-14 Matrix metalloproteinase-14 HSP90B1 Endoplasmin Endoplasmin GLB1 Beta-galactosidase Beta-galactosidase PTPRF Receptor-type tyrosine-protein phosphatase F Receptor-type tyrosine-protein phosphatase F STM Suppressor of tumorigenicity 14 protein Suppressor of tumorigenicity 14 protein PKN2 Serine / threonine-protein kinase N2 Serine / threonine-protein kinase N2 ARG1 Arginase-1 Arginase-1 PGAM1 Phosphoglycerate mutase 1 Phosphoglycerate mutase 1 PPP1CA Serine / threonine-protein phosphatase PP1-alpha catalytic subunit Serine / threonine-protein phosphatase PP1-alpha catalytic subunit PTP4A2 Protein tyrosine phosphatase type IVA 2 Protein tyrosine phosphatase type IVA 2 MAST1 Microtubule-associated     serine / threonine- protein kinase 1 Microtubule-associated serine / threonine-protein kinase 1 PI4KB Phosphatidylinositol 4-kinase beta Phosphatidylinositol 4-kinase beta VRK2 Serine / threonine-protein kinase VRK2 Serine / threonine-protein kinase VRK2 SCD Stearoyl-CoA desaturase Stearoyl-CoA desaturase NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 7,8 -dihydro- 8 -oxoguanine triphosphatase CSNK1G2 Casein kinase I isoform gamma-2 Casein kinase I isoform gamma-2 EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 Eukaryotic translation initiation factor 2-alpha kinase 3 ATP2A2 Sarcoplasmic / endoplasmic reticulum calcium ATPase 2 Sarcoplasmic / endoplasmic reticulum calcium ATPase 2 MAN1B1 Endoplasmic     reticulum     mannosyl- oligosaccharide 1,2-alpha-mannosidase Endoplasmic     reticulum     mannosyl- oligosaccharide 1,2-alpha-mannosidase CDKL5 Cyclin-dependent kinase-like 5 Cyclin-dependent kinase-like 5 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 Mitogen-activated protein kinase kinase kinase kinase 4 DPP8 Dipeptidyl peptidase 8 Dipeptidyl peptidase 8 MKNK1 MAP kinase-interacting serine / threonine-protein kinase 1 MAP kinase-interacting serine / threonine-protein kinase 1 PREP Prolyl endopeptidase Prolyl endopeptidase FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 SIRT1 NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacetylase sirtuin-1 STK3 Serine / threonine-protein kinase 3 Serine / threonine-protein kinase 3 LIG1 DNA ligase 1 DNA ligase 1 DUSP3 Dual specificity protein phosphatase 3 Dual specificity protein phosphatase 3 CAMKK2 Calcium / calmodulin-dependent protein kinase kinase 2 Calcium / calmodulin-dependent      protein kinase kinase 2 PRKAB1 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-1 MTR Methionine synthase Methionine synthase UCHL3 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Ubiquitin carboxyl-terminal hydrolase isozyme L3 ESRRB Steroid hormone receptor ERR2 Steroid hormone receptor ERR2 RI0K1 Serine / threonine-protein kinase RIO 1 Serine / threonine-protein kinase RIO1 TRAP1 Heat shock protein 75 kDa, mitochondrial Heat shock protein 75 kDa, mitochondrial PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 ALDH1A2 Retinal dehydrogenase 2 Retinal dehydrogenase 2 PAK6 Serine / threonine-protein kinase PAK 6 Serine / threonine-protein kinase PAK 6 AOX1 Aldehyde oxidase Aldehyde oxidase DPP9 Dipeptidyl peptidase 9 Dipeptidyl peptidase 9 ACPI Low molecular weight phosphotyrosine protein phosphatase Low molecular weight phosphotyrosine protein phosphatase PTPN7 Tyrosine-protein phosphatase non-receptor type 7 Tyrosine-protein phosphatase non-receptor type 7 TLK2 Serine / threonine-protein kinase tousled-like 2 Serine / threonine-protein kinase tousled-like 2 SMG1 Serine / threonine-protein kinase SMG1 Serine / threonine-protein kinase SMG1 YWHAZ 14-3-3 protein zeta / delta 14-3-3 protein zeta / delta ALDH1A1 Retinal dehydrogenase 1 Retinal dehydrogenase 1 PHF8 Histone lysine demethylase PHF8 Histone lysine demethylase PHF8 PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-1 PRMT3 Protein arginine N-methyltransferase 3 Protein arginine N-methyltransferase 3 SF3B3 Splicing factor 3B subunit 3 Splicing factor 3B subunit 3 AKT1S1 Proline-rich AKT1 substrate 1 Pro line-rich AKT1 substrate 1 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit alpha RPL36A 60S ribosomal protein L36a 60S ribosomal protein L36a RPL31 60S ribosomal protein L31 60S ribosomal protein L31 RPS16 40S ribosomal protein S16 40S ribosomal protein S16 RPS19 40S ribosomal protein S19 40S ribosomal protein S19 RPS12 40S ribosomal protein S12 40S ribosomal protein S12 RPL22 60S ribosomal protein L22 60S ribosomal protein L22 RPS25 40S ribosomal protein S25 40S ribosomal protein S25 RPL21 60S ribosomal protein L21 60S ribosomal protein L21 RPL23 60S ribosomal protein L23 60S ribosomal protein L23 RPS4Y1 40S ribosomal protein S4, Y isoform 1 40S ribosomal protein S4, Y isoform 1 RPL36 60S ribosomal protein L36 60S ribosomal protein L36 RPL27 60S ribosomal protein L27 60S ribosomal protein L27 RPS15A 40S ribosomal protein SI5a 40S ribosomal protein S15a RPS11 40S ribosomal protein Sil 40S ribosomal protein Sil RPL13A 60S ribosomal protein LI3a 60S ribosomal protein L13a RPL37 60S ribosomal protein L37 60S ribosomal protein L37 RPL7 60S ribosomal protein L7 60S ribosomal protein L7 RPL29 60S ribosomal protein L29 60S ribosomal protein L29 RPL27A 60S ribosomal protein L27a 60S ribosomal protein L27a RPL35A 60S ribosomal protein L35a 60S ribosomal protein L35a RPS26 40S ribosomal protein S26 40S ribosomal protein S26 RPL37A 60S ribosomal protein L37a 60S ribosomal protein L37a RPS29 40S ribosomal protein S29 40S ribosomal protein S29 RPS28 40S ribosomal protein S28 40S ribosomal protein S28 RPL17 60S ribosomal protein L17 60S ribosomal protein L17 FAU 40S ribosomal protein S30 40S ribosomal protein S30 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 Solute carrier family 2, facilitated glucose transporter member 3 ASAHI Acid ceramidase Acid ceramidase BTN3A1 Butyrophilin subfamily 3 member Al Butyrophilin subfamily 3 member Al NMT2 Glycylpeptide N-tetradecanoyltransferase 2 Glycylpeptide N-tetradecanoyltransferase 2 PI4KA Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 4-kinase alpha GNG2 Guanine     nucleotide-binding     protein G(I) / G(S) / G(O) subunit gamma-2 Guanine     nucleotide-binding     protein G(I) / G(S) / G(O) subunit gamma-2 GNA11 Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-11 PRMT8 Protein arginine N-methyltransferase 8 Protein arginine N-methyltransferase 8 LYPLA1 Acyl-protein thioesterase 1 Acyl-protein thioesterase 1 LGALS3 Galectin-3 Galectin-3 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 D3 S100A4 Protein S100-A4 Protein S100-A4 LGALS9 Galectin-9 Galectin-9 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha LGMN Legumain Legumain GNB1 Guanine     nucleotide-binding     protein G(I) / G(S) / G(T) subunit beta-1 Guanine     nucleotide-binding     protein G(I) / G(S) / G(T) subunit beta-1 HINT1 Histidine triad nucleotide-binding protein 1 Histidine triad nucleotide-binding protein 1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO Alpha-ketoglutarate-dependent dioxygenase FTO BRPF1 Peregrin Peregrin ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Beta-galactoside alpha-2,6-sialyltransferase 1 INPPL1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 PI4K2B Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-kinase type 2-beta PARP16 Protein        mono-ADP-ribosyltransferase PARP16 Protein       mono-ADP-ribosyltransferase PARP16 HEXA Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha SGPL1 Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase 1 MGAT2 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase LGALS8 Galectin-8 Galectin-8 ASH2L Setl / Ash2 histone methyltransferase complex subunit ASH2 Setl / Ash2 histone methyltransferase complex subunit ASH2 SARM1 NAD(+) hydrolase SARM1 NAD(+) hydrolase SARM1 LYPLA2 Acyl-protein thioesterase 2 Acyl-protein thioesterase 2 ASNS Asparagine     synthetase      [glutamine hydrolyzing] Asparagine     synthetase     [glutamine hydrolyzing] PABPC1 Polyadenylate-binding protein 1 Polyadenylate-binding protein 1 PRMT5 Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5 DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 WDR48 WD repeat-containing protein 48 WD rep eat-containing protein 48 WDR77 Methylosome protein 50 Methylosome protein 50 ATAD2B ATPase family AAA domain-containing protein 2B ATPase family AAA domain-containing protein 2B COPS5 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 5 PFKFB2 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 2 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 2 KDM4B Lysine-specific demethylase 4B Lysine-specific demethylase 4B PRKAB2 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit beta-2 MEN1 Menin Menin PMM2 Phosphomannomutase 2 Phosphomannomutase 2 RPTOR Regulatory-associated protein of mTOR Regulatory-associated protein of mTOR MLST8 Target of rapamycin complex subunit LST8 Target of rapamycin complex subunit LST8 DTYMK Thymidylate kinase Thymidylate kinase PTPN9 Tyrosine-protein phosphatase non-receptor type 9 Tyrosine-protein phosphatase non-receptor type 9 SHMT2 Serine            hydroxymethyltransferase, mitochondrial Serine           hydroxymethyltransferase, mitochondrial PARG Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) glycohydrolase GLS Glutaminase kidney isoform, mitochondrial Glutaminase kidney isoform, mitochondrial APAF1 Apoptotic protease-activating factor 1 Apoptotic protease-activating factor 1 KSR2 Kinase suppressor of Ras 2 Kinase suppressor of Ras 2 SORD Sorbitol dehydrogenase Sorbitol dehydrogenase SMS Spermine synthase Spermine synthase GALE UDP-glucose 4-epimerase UDP-glucose 4-epimerase PGD 6-phosphogluconate         dehydrogenase, decarboxylating 6-phosphogluconate        dehydrogenase, decarboxylating HNMT Histamine N-methyltransferase Histamine N-methyltransferase QDPR Dihydropteridine reductase Dihydropteridine reductase GSTK1 Glutathione S-transferase kappa 1 Glutathione S-transferase kappa 1 SRM Spermidine synthase Spermidine synthase FARS2 Phenylalanine—tRNA ligase, mitochondrial Phenylalanine—tRNA ligase, mitochondrial GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(i) subunit alpha-3 CLTC Clathrin heavy chain 1 Clathrin heavy chain 1 RHOC Rho-related GTP-binding protein RhoC Rho-related GTP-binding protein RhoC DNM1 Dynamin-1 Dynamin-1 GALNT10 Polypeptide                           N- acetylgalactosaminyltransferase 10 Polypeptide                            N- acetylgalactosaminyltransferase 10 MTHFD1 C-l-tetrahydro folate synthase, cytoplasmic C-l-tetrahydrofolate synthase, cytoplasmic RAB2A Ras-related protein Rab-2A Ras-related protein Rab-2A USP5 Ubiquitin carboxyl-terminal hydrolase 5 Ubiquitin carboxyl-terminal hydrolase 5 GDA Guanine deaminase Guanine deaminase UCK2 Uridine-cytidine kinase 2 Uridine-cytidine kinase 2 HIF1AN Hypoxia-inducible factor 1-alpha inhibitor Hypoxia-inducible factor 1-alpha inhibitor MDH2 Malate dehydrogenase, mitochondrial Malate dehydrogenase, mitochondrial CYP2E1 Cytochrome P450 2E1 Cytochrome P450 2E1 YWHAG 14-3-3 protein gamma 14-3-3 protein gamma GFPT1 Glutamine—ffuctose-6-phosphate aminotransferase [isomerizing] 1 Glutamine—fructose-6-phosphate aminotransferase [isomerizing] 1 FN1 Fibronectin Fibronectin PLAUR Urokinase plasminogen activator surface receptor Urokinase plasminogen activator surface receptor NCS1 Neuronal calcium sensor 1 Neuronal calcium sensor 1 GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-1 HCN2 Potassium / sodium        hyperpolarization- activated cyclic nucleotide-gated channel 2 Potassium / sodium       hyperpolarization- activated cyclic nucleotide-gated channel 2 QSOX1 Sulfhydryl oxidase 1 Sulfhydryl oxidase 1 TLR1 Toll-like receptor 1 Toll-like receptor 1 USP14 Ubiquitin carboxyl-terminal hydrolase 14 Ubiquitin carboxyl-terminal hydrolase 14 KSR1 Kinase suppressor of Ras 1 Kinase suppressor of Ras 1 RAB9A Ras-related protein Rab-9A Ras-related protein Rab-9A CCR7 C-C chemokine receptor type 7 C-C chemokine receptor type 7 PLCG2 1 -phosphatidylinositol      4,5-bisphosphate phosphodiesterase gamma-2 1 -phosphatidylinositol     4,5-bisphosphate phosphodiesterase gamma-2 GFER FAD-linked sulfhydryl oxidase ALR FAD-linked sulfhydryl oxidase ALR PTPRG Receptor-type tyrosine-protein phosphatase gamma Receptor-type tyrosine-protein phosphatase gamma FUT8 Alpha-( 1,6)-fucosyltransferase Alpha-( 1,6)-fucosyltransferase POR NADPH-cytochrome P450 reductase NADPH-cytochrome P450 reductase RECQL ATP-dependent DNA helicase Q1 ATP-dependent DNA helicase Q1 UNG Uracil-DNA glycosylase Uracil-DNA glycosylase CAD CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD protein [Includes: Glutaminedependent carbamoyl-phosphate synthase NCOA3 Nuclear receptor coactivator 3 Nuclear receptor coactivator 3 CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 KDM1B Lysine-specific histone demethylase IB Lysine-specific histone demethylase IB TEAD1 Transcriptional enhancer factor TEF-1 Transcriptional enhancer factor TEF-1 DDO D-aspartate oxidase D-aspartate oxidase CD4 T-cell surface glycoprotein CD4 T-cell surface glycoprotein CD4 SLC1A5 Neutral amino acid transporter B(0) Neutral amino acid transporter B(0) CD81 CD 81 antigen CD81 antigen GGT1 Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 proenzyme ADIPORI Adiponectin receptor protein 1 Adiponectin receptor protein 1 RAP1A Ras-related protein Rap-IA Ras-related protein Rap-1A RAB29 Ras-related protein Rab-7L 1 Ras-related protein Rab-7L 1 GOPC Golgi-associated PDZ and coiled-coil motifcontaining protein Golgi-associated PDZ and coiled-coil motifcontaining protein UTRN Utrophin Utrophin GNAO1 Guanine nucleotide-binding protein G(o) subunit alpha Guanine nucleotide-binding protein G(o) subunit alpha DDOST Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit PYGB Glycogen phosphorylase, brain form Glycogen phosphorylase, brain form RABGGTB Geranylgeranyl transferase type-2 subunit beta Geranylgeranyl transferase type-2 subunit beta VAV1 Proto-oncogene vav Proto-oncogene vav SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial QTRT1 Queuine tRNA-ribosyltransferase catalytic subunit 1 Queuine tRNA-ribosyltransferase catalytic subunit 1 CISD2 CDGSH iron-sulfur domain-containing protein 2 CDGSH iron-sulfur domain-containing protein 2 DHPS Deoxyhypusine synthase Deoxyhypusine synthase PPP2R5A Serine / threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine / threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PANK2 Pantothenate kinase 2, mitochondrial Pantothenate kinase 2, mitochondrial NEDD8 NEDD8 NEDD8 DOHH Deoxyhypusine hydroxylase Deoxyhypusine hydroxylase UBE2M NEDD8-conjugating enzyme Ube 12 NEDD8-conjugating enzyme Ubcl2 RNASEL 2-5A-dependent ribonuclease 2-5A-dependent ribonuclease SYNJ1 Synaptojanin-1 Synaptojanin-1 DUS2 tRNA-dihydrouridine(20)          synthase [NAD(P)+]-like tRNA-dihydrouridine(20)          synthase [NAD(P)+]-like CYCS Cytochrome c Cytochrome c PPPICC Serine / threonine-protein phosphatase PP1-gamma catalytic subunit Serine / threonine-protein phosphatase PP1-gamma catalytic subunit HMBS Porphobilinogen deaminase Porphobilinogen deaminase PNPO Pyridoxine-5'-phosphate oxidase Pyridoxine-5'-phosphate oxidase PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial Peptidyl-prolyl cis-trans isomerase F, mitochondrial DPP7 Dipeptidyl peptidase 2 Dipeptidyl peptidase 2 MARK1 Serine / threonine-protein kinase MARK1 Serine / threonine-protein kinase MARK1 PRCP Lysosomal Pro-X carboxypeptidase Lysosomal Pro-X carboxypeptidase PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma AKR1A1 Aldo-keto reductase family 1 member Al Aldo-keto reductase family 1 member Al MEI NADP-dependent malic enzyme NADP-dependent malic enzyme ACACA Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 1 CD74 EILA class II histocompatibility antigen gamma chain HLA class II histocompatibility antigen gamma chain NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 RUNX1 Runt-related transcription factor 1 Runt-related transcription factor 1 PTPRC Receptor-type tyrosine-protein phosphatase C Receptor-type tyrosine-protein phosphatase C CAPN2 Calpain-2 catalytic subunit Calpain-2 catalytic subunit RBI Retinoblastoma-associated protein Retinoblastoma-associated protein ITGA5 Integrin alpha-5 Integrin alpha-5 ITGA2 Integrin alpha-2 Integrin alpha-2 ADAM 10 Disintegrin and metalloproteinase domaincontaining protein 10 Disintegrin and metalloproteinase domaincontaining protein 10 DAGLB Diacylglycerol lipase-beta Diacylglycerol lipase-beta SLC16A1 Monocarboxylate transporter 1 Monocarboxylate transporter 1 ABCC2 ATP-binding cassette sub-family C member 2 ATP-binding cassette sub-family C member 2 SCARB1 Scavenger receptor class B member 1 Scavenger receptor class B member 1 DAGLA Diacylglycerol lipase-alpha Diacylglycerol lipase-alpha SLC47A1 Multidrug and toxin extrusion protein 1 Multidrug and toxin extrusion protein 1 PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta GBA2 Non-lysosomal glucosylceramidase Non-lysosomal glucosylceramidase NCEH1 Neutral cholesterol ester hydrolase 1 Neutral cholesterol ester hydrolase 1 WNK2 Serine / threonine-protein kinase WNK2 Serine / threonine-protein kinase WNK2 LIPE Hormone-sensitive lipase Hormone-sensitive lipase SLC27A1 Long-chain fatty acid transport protein 1 Long-chain fatty acid transport protein 1 PTPRA Receptor-type tyrosine-protein phosphatase alpha Receptor-type tyrosine-protein phosphatase alpha PTPN2 Tyrosine-protein phosphatase non-receptor type 2 Tyrosine-protein phosphatase non-receptor type 2 ITGB5 Integrin beta-5 Integrin beta-5 CTSH Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H MAN2B1 Lysosomal alpha-mannosidase Lysosomal alpha-mannosidase ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 2 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate receptor type 3 ABHD12 Lysophosphatidylserine lipase ABHD12 Lysophosphatidylserine lipase ABHD12 CTSZ Cathepsin Z Cathepsin Z SLC6A12 Sodium- and chloride-dependent betaine transporter Sodium- and chloride-dependent betaine transporter SLC6A11 Sodium- and chloride-dependent GABA transporter 3 Sodium- and chloride-dependent GABA transporter 3 KCNN3 Small conductance calcium-activated potassium channel protein 3 Small conductance calcium-activated potassium channel protein 3 SLC27A4 Long-chain fatty acid transport protein 4 Long-chain fatty acid transport protein 4 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 Tyrosine-protein phosphatase non-receptor type 6 AMPD3 AMP deaminase 3 AMP deaminase 3 PLEC Plectin Plectin PLD1 Phospholipase DI Phospholipase D1 PAM Peptidyl-glycine             alpha-amidating monooxygenase Peptidyl-glycine            alpha-amidating monooxygenase PRKD2 Serine / threonine-protein kinase D2 Serine / threonine-protein kinase D2 TYR03 Tyrosine-protein kinase receptor TYR03 Tyrosine-protein kinase receptor TYR03 RYR2 Ryanodine receptor 2 Ryanodine receptor 2 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma LIPA Lysosomal acid lipase / cholesteryl ester hydrolase Lysosomal acid lipase / cholesteryl ester hydrolase PPIB Peptidyl-prolyl cis-trans isomerase B Peptidyl-prolyl cis-trans isomerase B ATP2A3 Sarcoplasmic / endoplasmic reticulum calcium ATPase 3 Sarcoplasmic / endoplasmic reticulum calcium ATPase 3 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform Carnitine O-palmitoyltransferase 1, liver isoform ICMT Protein-S-isoprenylcysteine               0- methyltransferase Protein-S-isoprenylcysteine              0- methyltransferase HSD17B7 3 -keto-steroid              reductase / 17-beta- hydroxysteroid dehydrogenase 7 3 -keto-steroid             reductase / 17-beta- hydroxysteroid dehydrogenase 7 EL0VL6 Elongation of very long chain fatty acids protein 6 Elongation of very long chain fatty acids protein 6 DHCR7 7-dehydrocholesterol reductase 7-dehydrocholesterol reductase ATP2A1 Sarcoplasmic / endoplasmic reticulum calcium ATPase 1 Sarcoplasmic / endoplasmic reticulum calcium ATPase 1 RI0K3 Serine / threonine-protein kinase RI03 Serine / threonine-protein kinase RI03 HSPB1 Heat shock protein beta-1 Heat shock protein beta-1 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 12 PLAA Phospholipase A-2-activating protein Phospholipase A-2-activating protein MPI Mannose-6-phosphate isomerase Mannose-6-phosphate isomerase MATK Megakaryocyte-associated tyrosine-protein kinase Megakaryocyte-associated tyrosine-protein kinase UBA6 Ubiquitin-like modifier-activating enzyme 6 Ubiquitin-like modifier-activating enzyme 6 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 3 RPS6KA2 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-2 MAP3K4 Mitogen-activated protein kinase kinase kinase 4 Mitogen-activated protein kinase kinase kinase 4 PARP4 Protein mono-ADP-ribosyltransferase PARP4 Protein       mono-ADP-ribosyltransferase PARP4 EIF4H Eukaryotic translation initiation factor 4H Eukaryotic translation initiation factor 4H TESK1 Dual specificity testis-specific protein kinase 1 Dual specificity testis-specific protein kinase 1 MLX Max-like protein X Max-like protein X NEK6 Serine / threonine-protein kinase Nek6 Serine / threonine-protein kinase Nek6 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial Aldehyde dehydrogenase X, mitochondrial ATM Serine-protein kinase ATM Serine-protein kinase ATM CDYL Chromodomain Y-like protein Chromodomain Y-like protein TA0K1 Serine / threonine-protein kinase TAO 1 Serine / threonine-protein kinase TA01 STAT6 Signal transducer and activator of transcription 6 Signal transducer and activator of transcription 6 MGMT Methylated-DNA—protein-cysteine methyltransferase Methylated-DNA—protein-cysteine methyltransferase PPID Peptidyl-prolyl cis-trans isomerase D Peptidyl-prolyl cis-trans isomerase D STAT5B Signal transducer and activator of transcription 5B Signal transducer and activator of transcription 5B TXNRD2 Thioredoxin reductase 2, mitochondrial Thioredoxin reductase 2, mitochondrial TXNRD3 Thioredoxin reductase 3 Thioredoxin reductase 3 STK39 STE20 / SPS1 -related     proline-alanine-rich protein kinase STE20 / SPS1 -related proline-alanine-rich protein kinase STK38L Serine / threonine-protein kinase 38-like Serine / threonine-protein kinase 38-like CDC42BPA Serine / threonine-protein kinase MRCK alpha Serine / threonine-protein kinase MRCK alpha ATG4B Cysteine protease ATG4B Cysteine protease ATG4B DCLK2 Serine / threonine-protein kinase DCLK2 Serine / threonine-protein kinase DCLK2 TUBAL3 Tubulin alpha chain-like 3 Tubulin alpha chain-like 3 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 Mitogen-activated protein kinase kinase kinase 3 PPME1 Protein phosphatase methylesterase 1 Protein phosphatase methylesterase 1 RPLP1 60S acidic ribosomal protein Pl 60S acidic ribosomal protein Pl GSDMD Gasdermin-D Gasdermin-D C9 Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] HMGB1 Eligh mobility group protein B1 High mobility group protein B1 DAB2IP Disabled homolog 2-interacting protein Disabled homolog 2-interacting protein PHLPP1 PH domain leucine-rich rep eat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 1 PHKA2 Phosphorylase b kinase regulatory subunit alpha, liver isoform Phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA1 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform PHKB Phosphorylase b kinase regulatory subunit beta Phosphorylase b kinase regulatory subunit beta EWSR1 RNA-binding protein EWS RNA-binding protein EWS SLC16A3 Monocarboxylate transporter 4 Monocarboxylate transporter 4 PTPRE Receptor-type tyrosine-protein phosphatase epsilon Receptor-type tyrosine-protein phosphatase epsilon NEU1 Sialidase-1 Sialidase-1 PCSK6 Proprotein convertase subtilisin / kexin type 6 Proprotein convertase subtilisin / kexin type 6 ANTXR2 Anthrax toxin receptor 2 Anthrax toxin receptor 2 STIM1 Stromal interaction molecule 1 Stromal interaction molecule 1 DNM2 Dynamin-2 Dynamin-2 SDHB Succinate dehydrogenase [ubiquinone] ironsulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] ironsulfur subunit, mitochondrial MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 PTGES2 Prostaglandin E synthase 2 Prostaglandin E synthase 2 TMEM97 Sigma intracellular receptor 2 Sigma intracellular receptor 2 SPPL2A Signal peptide peptidase-like 2A Signal peptide peptidase-like 2A SLC7A11 Cystine / glutamate transporter Cystine / glutamate transporter ABHD6 Monoacylglycerol lipase ABHD6 Monoacylglycerol lipase ABHD6 DGKA Diacylglycerol kinase alpha Diacylglycerol kinase alpha NAPRT Nicotinate phosphoribosyltransferase Nicotinate phosphoribosyltransferase BAX Apoptosis regulator BAX Apoptosis regulator BAX SPTLC1 Serine palmitoyltransferase 1 Serine palmitoyltransferase 1 SPTLC2 Serine palmitoyltransferase 2 Serine palmitoyltransferase 2 MGAT1 Alpha-l,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Alpha-1,3 -mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase EPHX1 Epoxide hydrolase 1 Epoxide hydrolase 1 FADS1 Acyl-CoA Acyl-CoA ABHD5 l-acylglycerol-3-phosphate O-acyltransferase ABHD5 l-acylglycerol-3-phosphate              0- acyltransferase ABHD5 CBFB Core-binding factor subunit beta Core-binding factor subunit beta P0LR1A DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA1 MPG DNA-3-methyladenine glycosylase DNA-3-methyladenine glycosylase GYSI Glycogen [starch] synthase, muscle Glycogen [starch] synthase, muscle PRKAG2 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-2 ASF1A Histone chaperone ASF1A Histone chaperone ASF 1A MED23 Mediator of RNA polymerase II transcription subunit 23 Mediator of RNA polymerase II transcription subunit 23 PFKFB4 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 4 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 4 KDM3A Lysine-specific demethylase 3A Lysine-specific demethylase 3A USP9X Probable     ubiquitin     carboxyl-terminal hydrolase FAF-X Probable ubiquitin carboxyl-terminal hydrolase FAF-X MAX Protein max Protein max MBD2 Methyl-CpG-binding domain protein 2 Methyl-CpG-binding domain protein 2 CBX8 Chromobox protein homolog 8 Chromobox protein homolog 8 FLU Friend leukemia integration 1 transcription factor Friend leukemia integration 1 transcription factor ATRIP ATR-interacting protein ATR-interacting protein RICTOR Rapamycin-insensitive companion of mTOR Rapamycin-insensitive companion of mTOR UBLCP1 Ubiquitin-like domain-containing CTD phosphatase 1 Ubiquitin-like domain-containing CTD phosphatase 1 DCTPP1 dCTP pyrophosphatase 1 dCTP pyrophosphatase 1 TCF4 Transcription factor 4 Transcription factor 4 CNOT7 CCR4-N0T transcription complex subunit 7 CCR4-N0T transcription complex subunit 7 OGFRL1 Opioid growth factor receptor-like protein 1 Opioid growth factor receptor-like protein 1 MVD Diphosphomevalonate decarboxylase Diphosphomevalonate decarboxylase IL6ST Interleukin-6 receptor subunit beta Interleukin-6 receptor subunit beta DOCK2 Dedicator of cytokinesis protein 2 Dedicator of cytokinesis protein 2 C3 Complement C3 Complement C3 PPM1A Protein phosphatase 1A Protein phosphatase 1A SHC1 SHC-transforming protein 1 SHC-transforming protein 1 DVL2 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-2 NPR3 Atrial natriuretic peptide receptor 3 Atrial natriuretic peptide receptor 3 GSTM1 Glutathione S-transferase Mu 1 Glutathione S-transferase Mu 1 PPP3CA Serine / threonine-protein phosphatase 2B catalytic subunit alpha isoform Serine / threonine-protein phosphatase 2B catalytic subunit alpha isoform SLC12A2 Solute carrier family 12 member 2 Solute carrier family 12 member 2 ABCC3 ATP-binding cassette sub-family C member 3 ATP-binding cassette sub-family C member 3 ABCC4 ATP-binding cassette sub-family C member 4 ATP-binding cassette sub-family C member 4 GGH Gamma-glutamyl hydrolase Gamma-glutamyl hydrolase HCN3 Potassium / sodium        hyperpolarization- activated cyclic nucleotide-gated channel 3 Potassium / sodium       hyperpolarization- activated cyclic nucleotide-gated channel 3 ADCY1 Adenylate cyclase type 1 Adenylate cyclase type 1 ADCY5 Adenylate cyclase type 5 Adenylate cyclase type 5 CYP4F2 Cytochrome P450 4F2 Cytochrome P450 4F2 HKDC1 Hexokinase HKDC1 Hexokinase HKDC1 PPT1 Palmitoyl-protein thioesterase 1 Palmitoyl-protein thioesterase 1 PRNP Major prion protein Major prion protein CXCR5 C-X-C chemokine receptor type 5 C-X-C chemokine receptor type 5 SMPD2 Sphingomyelin phosphodiesterase 2 Sphingomyelin phosphodiesterase 2 SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 Sodium-dependent neutral amino acid transporter B(0)AT2 MANBA Beta-mannosidase Beta-mannosidase AGPAT2 l-acyl-sn-glycerol-3-phosphate acyltransferase beta l-acyl-sn-glycerol-3-phosphate acyltransferase beta ABHD16A Phosphatidylserine lipase ABHD16A Phosphatidylserine lipase ABHD16A GCLC Glutamate-cysteine ligase catalytic subunit Glutamate-cysteine ligase catalytic subunit HAGH Hydroxyacylglutathione          hydrolase, mitochondrial Hydroxyacylglutathione         hydrolase, mitochondrial SENP1 Sentrin-specific protease 1 Sentrin-specific protease 1 DNAJA1 DnaJ homolog subfamily A member 1 DnaJ homolog subfamily A member 1 SCP2 Sterol carrier protein 2 Sterol carrier protein 2 AMPD2 AMP deaminase 2 AMP deaminase 2 ERCC5 DNA repair protein complementing XP-G cells DNA repair protein complementing XP-G cells SENP7 Sentrin-specific protease 7 Sentrin-specific protease 7 RBPJ Recombining binding protein suppressor of hairless Recombining binding protein suppressor of hairless USP47 Ubiquitin carboxyl-terminal hydrolase 47 Ubiquitin carboxyl-terminal hydrolase 47 NADK NAD kinase NAD kinase RBBP9 Serine hydrolase RBBP9 Serine hydrolase RBBP9 CD2 T-cell surface antigen CD2 T-cell surface antigen CD2 CD44 CD44 antigen CD44 antigen SLC27A2 Very long-chain acyl-CoA synthetase Very long-chain acyl-CoA synthetase PLEKHA1 Pleckstrin homology domain-containing family A member 1 Pleckstrin homology domain-containing family A member 1 ITGA3 Integrin alpha-3 Integrin alpha-3 CD47 Leukocyte surface antigen CD47 Leukocyte surface antigen CD47 SPPL2B Signal peptide peptidase-like 2B Signal peptide peptidase-like 2B PLTP Phospholipid transfer protein Phospholipid transfer protein CD63 CD63 antigen CD63 antigen SLC20A2 Sodium-dependent phosphate transporter 2 Sodium-dependent phosphate transporter 2 ADCY6 Adenylate cyclase type 6 Adenylate cyclase type 6 IGF2R Cation-independent mannose-6-phosphate receptor Cation-independent mannose-6-phosphate receptor EZR Ezrin Ezrin GNAQ Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein G(q) subunit alpha INPP5A Inositol polyphosphate-5-phosphatase A Inositol polyphosphate-5-phosphatase A CRACR2A EF-hand calcium-binding domain-containing protein 4B EF-hand calcium-binding domain-containing protein 4B LANCL2 LanC-like protein 2 LanC-like protein 2 SMPD3 Sphingomyelin phosphodiesterase 3 Sphingomyelin phosphodiesterase 3 EHD1 EH domain-containing protein 1 EH domain-containing protein 1 PDIA6 Protein disulfide-isomerase A6 Protein disulfide-isomerase A6 CHN2 Beta-chimaerin Beta-chimaerin CDH2 Cadherin-2 Cadherin-2 TFPI Tissue factor pathway inhibitor Tissue factor pathway inhibitor CD58 Lymphocyte function-associated antigen 3 Lymphocyte function-associated antigen 3 SLC2A8 Solute carrier family 2, facilitated glucose transporter member 8 Solute carrier family 2, facilitated glucose transporter member 8 PTPRM Receptor-type tyrosine-protein phosphatase mu Receptor-type tyrosine-protein phosphatase mu STIM2 Stromal interaction molecule 2 Stromal interaction molecule 2 ADCY7 Adenylate cyclase type 7 Adenylate cyclase type 7 SLC20A1 Sodium-dependent phosphate transporter 1 Sodium-dependent phosphate transporter 1 ITGA1 Integrin alpha-1 Integrin alpha-1 RABGGTA Geranylgeranyl transferase type-2 subunit alpha Geranylgeranyl transferase type-2 subunit alpha MAP IB Microtubule-associated protein IB Microtubule-associated protein IB PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit alpha2 Platelet-activating factor acetylhydrolase IB subunit alpha2 RIN1 Ras and Rab interactor 1 Ras and Rab interactor 1 PLCD1 1 -phosphatidylinositol      4,5-bisphosphate phosphodiesterase delta-1 1 -phosphatidylinositol     4,5-bisphosphate phosphodiesterase delta-1 RGS19 Regulator of G-protein signaling 19 Regulator of G-protein signaling 19 PNPLA2 Patatin-like phospholipase domain-containing protein 2 Patatin-like     phospholipase     domain containing protein 2 ST3GAL3 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3 -sialyltransferase GALNT1 Polypeptide                           N- acetylgalactosaminyltransferase 1 Polypeptide                            N- acetylgalactosaminyltransferase 1 ATP6V1B2 V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, brain isoform ATP6AP1 V-type proton ATPase subunit S1 V-type proton ATPase subunit SI PHLPP2 PH domain leucine-rich rep eat-containing protein phosphatase 2 PH domain leucine-rich repeat-containing protein phosphatase 2 GNPAT Dihydroxyacetone phosphate acyltransferase Dihydroxyacetone phosphate acyltransferase PPP3CB Serine / threonine-protein phosphatase 2B catalytic subunit beta isoform Serine / threonine-protein phosphatase 2B catalytic subunit beta isoform SLC25A20 Mitochondrial camitine / acylcamitine carrier protein Mitochondrial camitine / acylcamitine carrier protein EL0VL1 Elongation of very long chain fatty acids protein 1 Elongation of very long chain fatty acids protein 1 MAN2A1 Alpha-mannosidase 2 Alpha-mannosidase 2 SLC33A1 Acetyl-coenzyme A transporter 1 Acetyl-coenzyme A transporter 1 GABI GRB2-associated-binding protein 1 GRB2-associated-binding protein 1 ARHGEF12 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 12 MAP2 Microtubule-associated protein 2 Microtubule-associated protein 2 MBTD1 MBT domain-containing protein 1 MBT domain-containing protein 1 PNKP Bifunctional                  polynucleotide phosphatase / kinase Bifunctional                 polynucleotide phosphatase / kinase NLRP1 NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1 TXN2 Thioredoxin, mitochondrial Thioredoxin, mitochondrial EEF1A2 Elongation factor 1-alpha 2 Elongation factor 1-alpha 2 GOT1 Aspartate aminotransferase, cytoplasmic Aspartate aminotransferase, cytoplasmic PRMT7 Protein arginine N-methyltransferase 7 Protein arginine N-methyltransferase 7 MYH10 Myosin-10 Myosin-10 TPP2 Tripeptidyl-peptidase 2 Tripeptidyl-peptidase 2 EYA3 Eyes absent homolog 3 Eyes absent homolog 3 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 AMDHD2 N-acetylglucosamine-6-phosphate deacetylase N-acetylglucosamine-6-phosphate deacetylase CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial MECP2 Methyl-CpG-binding protein 2 Methyl-CpG-binding protein 2 KPNA2 Importin subunit alpha-1 Importin subunit alpha-1 PSMG1 Proteasome assembly chaperone 1 Proteasome assembly chaperone 1 CBX6 Chromobox protein homolog 6 Chromobox protein homolog 6 PPP2R2A Serine / threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Serine / threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-conjugating enzyme E2 variant 1 PSMG2 Proteasome assembly chaperone 2 Proteasome assembly chaperone 2 PPIC Peptidyl-prolyl cis-trans isomerase C Peptidyl-prolyl cis-trans isomerase C PGK2 Phosphoglycerate kinase 2 Phosphoglycerate kinase 2 S0S1 SOS Ras / Rac guanine nucleotide exchange factor 1 SOS Ras / Rac guanine nucleotide exchange factor 1

[0066] In some embodiments, the PBM-Rf- can be a small molecule ligand that targets and binds to specific target proteins, including but not limited to, epidermal growth factor receptor (EGFR), Cyclin-dependent kinase 4 / 6 (CDK4 / 6), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), fibroblast growth factor receptors (FGFRs), proto-oncogene tyrosine-protein kinase receptor RET (RET), Focal adhesion kinase (FAK), breakpoint cluster region (BCR)-Abelson leukemia virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), Androgen receptor (AR), Estrogen receptor (ER), Bromodomain and extra-terminal domain protein (BET), Interleukin-1 receptor-associated kinase 4 (IRAK4), Cyclin-dependent kinase 9 (CDK9), Histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic receptor tyrosine kinase (NTRK), Src homology 2 domain containing protein tyrosine phosphatase (SHP2), Poly (ADP-ribose) polymerase (PARP), signal transducers and activators of transcription 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), B cell lymphoma-2 (BCL-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS 1), or GTPase Kras (KRAS).

[0067] In some embodiments, PBM comprises the structures of the following formula: Formula (PBM-4) Formula (PBM-1)           Formula (PBM-2) Formula (PBM-3) Formula (PBM-13) Formula (PBM-14)                         Formula (PBM-15) Formula (PBM-19) Formula (PBM-24)                Formula (PBM-25) Formula (PBM-27) Formula (PBM-28)                 Formula (PBM-29)           Formula (PBM-30)          Formula (PBM-31) (R152)p58   <R153)p« qj-             Formula (PBM-53)            • wherein (R^pi indicates that the benzene ring in Formula (PBM-1) is substituted with pl R1, with each R1 being the same or different and independently representing halogen, hydroxy, NH2, NO2, cyano, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R2)P2 indicates that the quinazoline ring in Formula (PBM-1) is substituted with p2 R2, with each R2 being the same or different and independently representing halogen, NO2, cyano, halogenated C1-6 alkyl, Ci-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, halogenated C1-10 alkoxy, -O-optionally substituted heterocyclyl, or -NHC(O)R3, wherein R3 is C1-10 alkyl, deuterated C1-10 alkyl, or C2-10 0          __ __ ,                              Xy° • / X / ° alkenyl, e.g., R represents methyl, methoxy, h or o , such as ^'o      ; pl represents an integer of 1, 2, 3, 4 or 5; p2 represents an integer of 1, 2, or 3; (R4)P3 indicates that the benzene ring in Formula (PBM-2) is substituted with p3 R4, with each R4 being the same or different and independently representing halogen, NO2, cyano, halogenated C1-6 alkyl, Ci-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, or -NHC(O)R15a, where R15a is C1-10 alkyl, 0 4 deuterated C1-10 alkyl, or C2-10 alkenyl, e.g., R represents methyl, methoxy, NO2, or h ; p3 represents an integer of 1, 2, 3 or 4; (R5)P4 indicates that the IH-indole ring in Formula (PBM-2) is substituted with p4 R5, with each R5 being the same or different and independently representing hydrogen, C1-10 alkyl or deuterated Ci-10 alkyl, and p4 represents an integer of 0, 1, 2 or 3; R6 represents hydrogen, C1-10 alkyl, or deuterated C1-10 alkyl; (R7)P5 indicates that the benzene ring in Formula (PBM-3) is substituted with p5 R7, with each R7 being the same or different and independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, or cyano; p5 represents an integer of 0, 1, 2, 3, 4 or 5; R8 represents substituted or unsubstituted C3-15 cycloalkyl, such as Cyclopentyl; (R9)P6 indicates that the benzene ring in Formula (PBM-4) is substituted with p6 R9, with each R9 being the same or different and independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, C1-6 alkoxy, halogenated C1-6 alkoxy, or cyano; p6 represents an integer of 2, 3, 4 or 5; R10 represents Ce-io aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the Ce io aryl and heteroaryl are each optionally substituted with one or more Rbl, with each Rbl being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy; (Rn)P7 indicates that the benzene ring and the pyridine ring in Formula (PBM-5) are each optionally substituted with p7 R11, with each p7 being the same or different and independently representing an integer of 0, 1, 2 or 3, and each R11 in Formula (PBM-5) is the same or different and each independently represents hydrogen, halogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl; R12 represents hydrogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl; R13 in Formula (PBM-6) represents hydrogen, Cmo alkyl (e.g.,^ ), deuterated Cmo alkyl or halogenated Cmo alkyl; o                      (Rb2)p8 R14 represents nsT* or \— / . wherein (Rb2)P8 indicates that the piperidine ring is optionally substituted with p8 Rb2, with each Rb2 being the same or different and independently representing deuterium, halogen, hydroxy, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, NO2, NH2, or cyano, p8 represents an integer of 1,2, 3, 4 or 5; ring A in Formula (PBM-7) represents Ce io aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring A is optionally substituted with one or more Rb3, with each Rb3 being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C2-6 alkenyl, or C2-6 alkynyl; ring B in Formula (PBM-7) represents C3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring B is optionally substituted with one or more Rb4, with each RM being the same or different and independently representing deuterium, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; ring C in Formula (PBM-7) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring C is optionally substituted with one or more Rb5, with each Rb5 being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R15 in Formula (PBM-8) represents 4- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heterocyclyl is optionally substituted with one or more Rb6, with each Rb6 being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy; (R16)P9 indicates that the benzene ring in Formula (PBM-8) is substituted with p9 R16, with each R16 being the same or different and independently representing halogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl, and p9 represents an integer of 1, 2, 3 or 4; Xi in Formula (PBM-9) represents N or CRb7, wherein Rb7 is hydrogen or amino, and X2 represents N or CR17, wherein R17 is hydrogen or represents a bond, and X3 represents CH or N; R18 and R19 each independently represent hydrogen or a bond; (R2O)pio indicates that the benzene ring in Formula (PBM-9) is substituted with plO R20, with each R20 being the same or different and independently representing -O-aryl, -O-heteroaryl, -C1-3 alkylene-NHC(O)-heteroaryl, -C1-3 alkylene-C(O)NH-heteroaryl or halogen, wherein the aryl and heteroaryl are each independently optionally substituted with one or more Rb8, with each Rb8 being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; plO represents an integer of 1, 2, 3 or 4; R21 represents a bond, deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated Ci-6 alkyl, or Ci-6 alkoxy; R22 represents hydrogen, halogen, cyano, or amino; wherein R17, R18, R19, and R21 are not simultaneously hydrogen, and R17, R18, R19, and R21 do not simultaneously represent a bond, and only one of R17, R18, R19, and R21 represents a bond, wherein when R18 represents a bond, the carbon atom on the ring connected to R18 is directly connected to Rf, X2 represents CH or N, and R19 is hydrogen, and R21 is not a bond; when X2 represents CR17, where R17 represents a bond, the carbon atom on the ring connected to R17 is directly connected to Rf, and R18 and R19 are hydrogen, and R21 is not a bond; when R19 represents a bond, the nitrogen atom on the ring connected to R19 is directly connected to Rf, X2 represents N or CH, and R18 is hydrogen, and R21 is not a bond; and when R21 represents a bond, the carbon atom on the ring connected to R21 is directly connected to Rf, and X2 represents N or CH, and R18 and R19 are hydrogen; (R23)pii indicates that the cyclopentene ring in Formula (PBM-10) is substituted with pl 1 R23, with each R23 being the same or different and independently representing halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and pl 1 represents an integer of 1, 2, 3, or 4; (R24)pi2 indicates that the pyridine ring in Formula (PBM-10) is substituted with pl2 R24, with each R24 being the same or different and independently representing halogen, -C1-3 alkylene-OH, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p 12 represents an integer of 1, 2, or 3; R25 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; X4 in Formula (PBM-11) represents CR26 or a fragment R‘ # **, wherein symbol # indicates the point of attachment to N atom adjacent to X4, symbol ## indicates the point of attachment to X5, and R26 represents deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, -C(O)-Ci-6 alkyl, -C(O)-deuterated C1-6 alkyl, or -C(O)NRb9Rb10, where Rb9 and Rbl° are the same or different and each independently represent hydrogen, C1-6 alkyl or deuterated C1-6 alkyl; X5 in Formula (PBM-11) represents N or CR27, where R27 represents hydrogen, deuterium, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; Xe and X7 each independently represent CH or N; R28 represents a bond or optionally substituted heteroarylene (e.g., halogenated heteroarylene); R29 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-7 cycloalkyl; R30 and R31 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R32 in Formula (PBM-12) represents hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R33 represents hydrogen, cyano, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; (R34)pi3 indicates that the benzene ring in Formula (PBM-13) is substituted with p 13 R34, with each R34 being the same or different and independently representing halogen, hydroxy, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; p 13 represents an integer of 1, 2, 3, 4 or 5; R35 represents NRbllRb12, where Rbl1 and Rbl2 are the same or different and each independently represent hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; (R36)pi4 indicates that the benzene ring in Formula (PBM-14) is optionally substituted with pl4 R36, with each R36 in Formula (PBM-14) being the same or different and independently representing halogen, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6alkyl, and pl4 represents an integer of 1, 2 or 3; R37 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; Xg, X9, X10, Xu and X12 in Formula (PBM-15) are the same or different and each independently represent N or CH; R38 represents a bond or optionally substituted methylene (e.g., halogenated methylene); R39 represents -C(O)NHRb13, -NHC(O)-Rb13, -S(O)2NHRb13, -N(Rbl4)S(O)2Rb13, -S(O)2Rb13 or -P(O)(Rbl3)2, wherein each Rbl3 is the same or different and each independently represents Ci-6 alkyl or deuterated Ci-6 alkyl, and Rbl4 represents hydrogen or Ci-6 alkyl; (R40)pi5 indicates that the 6-membered ring containing X9 and X10 in Formula (PBM-15) is optionally substituted with pl5 R40, with each R40 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; pl5 represents an integer of 0, 1, 2, 3 or 4; R41 represents halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; (R42)pi6 indicates that the benzene ring in Formula (PBM-16) is optionally substituted with pl6 R42, with each R42 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; each pl6 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; (R43)pi7 indicates that the benzene ring in Formula (PBM-17) is substituted with pl7 R43, with each R43 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and pl7 represents an integer of 0, 1, 2, 3 or 4; (R44)pi8 indicates that the benzene ring in Formula (PBM-18) is optionally substituted with pl8 R44, with each R44 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; pl8 represents an integer of 0, 1, 2, 3 or 4; (R45)pi9 indicates that the 4-oxo-3,4-dihydroquinazoline ring in Formula (PBM-18) is substituted with p 19 R45, with each R45 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; pl9 represents an integer of 1, 2, 3 or 4; (R46)p2o indicates that the benzene ring in Formula (PBM-19) is substituted with p20 R46, with each R46 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p20 represents an integer of 1, 2, 3, 4 or 5; R47 represents halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; (R48)p2i indicates that the quinoline ring in Formula (PBM-20) is substituted with p21 R48, with each R48 being the same or different and independently representing halogen, cyano, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p21 represents an integer of 1, 2, 3 or 4; (R49)p22 indicates that the benzene ring in Formula (PBM-20) is substituted with p22 R49, with each R49 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p22 represents an integer of 2, 3 or 4; R50 in Formula (PBM-21) represents -NHC(O)- or -C(O)NH-; R51 represents -NH- or ethynylene; (R52)p23 indicates that the benzene rings in Formula (PBM-21) are each optionally substituted with p23 R52, with each R52 being the same or different and independently representing halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl; each p23 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; ring D in Formula (PBM-21) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R53)P24 indicates that the ring D is optionally substituted with p24 R53, with each R53 being the same or different and independently representing optionally substituted 5- to 15-membered heteroaryl, deuterium, halogen, hydroxy, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy; p24 represents an integer of 0, 1, 2, or 3; only one of R54, R55, R56, and R57 in Formula (PBM-22) represents a bond, and the remaining are the same or different and each independently represent hydrogen, halogen, or hydroxy, wherein when one of R54, R55, R56 and R57 represents a bond, the benzene ring or methylene in Formula (PBM-22) connected to the bond is directly connected to Rf; symbol “.~w” connected to a double bond in Formula (PBM-22) represents a bond in stereoconfiguration (cis or trans configuration, or E- or Z-configuration); X13 in Formula (PBM-23) represents -O- or -CH2-; (R58)p25 indicates that 1,2,3,4-tetrahydronaphthalene ring in Formula (PBM-23) is substituted with p25 R58, with each R58 being the same or different and independently representing hydrogen, hydroxy, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; p25 represents an integer of 1, 2, 3 or 4; one of R59 and R60 represents a bond, and another represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, wherein when one of R59 and R60 represents a bond, the carbon atom on the ring in Formula (PBM-23) connected to the bond is directly connected to Rf; ring E in Formula (PBM-24) represents 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; R62 represents optionally substituted 5- to 15-membered heteroaryl, optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R61 represents halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R63 in Formula (PBM-25) represents optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R64 represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heteroaryl is optionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, or any combination thereof; (R65)P26 indicates that the isoquinoline ring in Formula (PBM-26) is substituted with p26 R65, with each R65 being the same or different and independently representing hydrogen, hydroxy, halogen, Ci-6 alkyl, Ci-6 alkoxy, -C(O)NH2, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl; p26 represents an integer of 1, 2, 3 or 4; groups R66 are the same or different and each independently represent hydrogen, hydroxy, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl; X14 in Formula (PBM-27) represents N or CRb23, where Rb23 represents hydrogen or halogen, and X15 represents N or CH; R67 represents a bond, -C(O)NH- or -NHC(O)-; R68 represents halogen, Ci-6 alkyl, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl; R69 represents hydrogen, Ci-6 alkyl, deuterated Ci-6 alkyl, halogenated Ci-6 alkyl, or -C1-3 alkylene-C3-6 cycloalkyl; R70 represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; or R69 and R70 together with the corresponding nitrogen and carbon atoms to which they are connected form an optionally substituted 5- to 7-membered nifrogen-containing heterocycle; R71 represents hydrogen or a bond, R72 represents hydrogen or a bond, wherein R71 and R72 are not simultaneously hydrogen, and only one of R71 and R72 represents a bond, and another represents hydrogen, wherein when R71 represents a bond, the carbon atom on the ring connected to R71 is directly connected to Rf, and when R72 represents a bond, the carbon atom on the ring connected to R72 is directly connected to Rf; R74 in Formula (PBM-28) represents C1-3 alkylene or halogenated C1-3 alkylene; R73 represents optionally substituted C3-6 cycloalkyl, halogenated C3-6 cycloalkyl, or optionally substituted C1-6 alkyl; R75 in Formula (PBM-29) represents C1-3 alkylene or halogenated C1-3 alkylene; R76 represents C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-6 cycloalkyl; R77 in Formula (PBM-30) represents C1-3 alkylene or halogenated C1-3 alkylene; R78 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R79 and R80 are the same or different and each independently represent hydrogen, optionally substituted Cmo alkyl or optionally substituted C3-6 cycloalkyl; R81 represents hydrogen, halogen, Ci-6 alkyl, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl; Xi6 in Formula (PBM-31) represents -S- or a fragment , wherein when Xi6 represents -S-, heteroaryl containing Xi6 and nitrogen atom in Formula (PBM-31) is thiazolyl, and when Xi6 represents the fragment . the heteroaryl containing Xi6 and nitrogen atom in Formula (PBM-31) is pyridyl; X17 represents N or CH; R82 represents hydrogen or optionally substituted Ci-io alkyl; R83 represents hydrogen, -C1-3 alkylene-optionally substituted 4- to 10-membered heterocyclyl, or optionally substituted 4- to 10-membered heterocyclyl; R84 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R85 and R86 in Formula (PBM-32) are the same or different and each independently represent hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R87 represents -S(O)2NH2 or -C(O)NH2; R88 in Formula (PBM-33) represents hydrogen, hydroxy, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R89 represents C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; or R88 and R89 together with the corresponding carbon and nitrogen atoms to which they are connected form an optionally substituted 4- to 6-membered heteroaromatic ring or optionally substituted 4- to 6-membered heterocycle; R90 represents optionally substituted C3-6 cycloalkyl, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl or optionally substituted 4- to 10-membered heterocyclyl; (R91)p27 indicates that pyridin-2(lH)-one ring in Formula (PBM-33) is substituted with p27 R91, with each R91 being the...

Claims

1. A compound of Formula (I)Formula (I)or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Ra)m indicates that benzene ring is substituted with m Ra substituents, with each Ra being the sameor different and independently representing the structure of the following formula:R5wherein R represents chlorine, bromine, iodine, hydroxy, leaving group, NR?Rs or a groupwherein R7 and Rs are the same or different and independently represent hydrogen, C1-6 alkyl, C2-6alkynyl-Ci-6 alkylene-, C2-6 alkenyl-Ci-6 alkylene-, optionally substituted 4- to 15membered nitrogen-containing heterocyclyl, or R2a-Rla-, where Rla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R2a represents halogen, amino, hydroxy, carboxyl, C2-6 alkynyl, C2-6 alkenyl or a leaving group; andW1 represents the structure of the following formula:wherein ring W2 represents optionally substituted nitrogen-containing heterocyclyl, each ring W3 is the same or different and independently represents optionally substituted nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, and ring W4 represents optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl;Rs and Re are the same or different and independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacentcarbon atoms in the backbone carbon chain is interrupted by the group Rc, Ra, or a combination of Rc and Ra; wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, S(0), S(0)2, S(O)2NH, NHS(O)2, 0C(0), C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or Ci-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-3o alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Ra is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-Ci-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;orR and Rs, together with the carbon atom to which they are connected, form carbonyl group, Re represents hydrogen, optionally substituted methyl, or optionally substituted linear or branched C2-3o alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-3o alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of 0, N(Re), C(0), C(0)0, S(0), S(0)2, S(O)2NH, NHS(O)2, 0C(0), C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-3o alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-Ci-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;(Rb)n indicates that the benzene ring is substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino,cyano, optionally deuterated Ci-6 alkyl, optionally deuterated Ci-6 alkoxy, halogenated Ci-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl; andm represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4;wherein when R and Rs together with the carbon atom to which they are connected form a carbonyl group and Re represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4;with the proviso that the following compounds and compounds of Formula (I’) are excluded:0when A represents CH2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0;when A represents CH2 or C(O) and Ra represents H2N-CH2-, m represents an integer of 1 and n represents an integer of 0;when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; andthe compounds of Formula (I’):Formula (I’)wherein in Formula (I’), A represents CH2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

2. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (1-1) or Formula (1-2):n(Rb) PR R3R2r         n(Rb) OR R3R2rm(Ra) [T                          m(Ra) H-z^nh         \A^a z^nhO                       0Formula (I-1)             Formula (1-2)wherein A, Ri, R2, R3, R4, Ra, Rb, m, and n are as defined in claim 1.

3. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein R represents:chlorine, bromine, iodine, hydroxy, or leaving group; orNR7R8, wherein R7 and Rs are the same or different and each independently represent hydrogen, C1-6 alkyl, C2-6 alkynyl-Ci-6 alkylene, C2-6 alkenyl-Ci-6 alkylene, optionally substituted 4- to 15membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, optionally substituted 4- to 15-membered nitrogencontaining spiro-heterocyclyl, or R2a-Rla-, wherein Rla represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R2a represents halogen, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl or leaving group, and the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15membered nitrogen-containing spiro-heterocyclyl are each optionally substituted with one or more substituents selected from the group consisting of deuterium, C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, R4a-R3a-, or any combination thereof, where R3a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl; ormercapto, cyano, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;W1 represented by the structure of the following formula:(Ra1)miwherein ring W2 represents 4- to 20-membered nitrogen-containing heterocyclyl, (Ral)mi indicates that ring W2 is optionally substituted with ml Ral substituents, with each Ral independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R8a-R7a-, where R7a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R8a represents halogen, R9aR10aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl; or(Ra3)m3 (RaZ)m2wherein each ring W3 is the same or different and independently represents 4- to 20membered nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group,amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, where Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; andring W4 represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, (Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, and each Ra3 independently represents deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl;wherein ml, m2, and m3 independently represent an integer of 0-20.

4. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, whereinR represents NR7R8, where R7 and Rs are the same or different and each independently represent: hydrogen, C1-6 alkyl, C2-6alkynyl-Ci-6 alkylene, C2-6 alkenyl-Ci-6 alkylene; or optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, or optionally substituted 4- to 15-membered nitrogen-containing spiro-heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo [3. l.l]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo [3.1.1 ]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, orHN-x                  ^nh        H / NJN s         ^TnhHN^       HN^           HN^       HN^rfY rOH Tf™hnV \_Np hnV hnV \nV hnV hnv \-nh hnvR2a.Rla.5 where Rla represents optionally substituted Ci-6 alkylene or optionally substituted C2-6 alkenylene, and R2a represents halogen, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, or leaving group,wherein the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15membered nitrogen-containing bridged heterocyclyl and the 4- to 15-membered nitrogencontaining spiro-heterocyclyl are each optionally substituted with one or more substituents selected from the group consisting of deuterium, C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, R4a-R3a-, or any combination thereof, where R3a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl; orR represents W1 represented by the structure of the following formula:(Ra1)miwherein ring W2 represents 4- to 20-membered nitrogen-containing heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl,pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl,azacyclooctyl, diazacyclooctyl, azabicyclo [3. l.l]heptanyl,  azabicyclo[2.2.1]heptanyl,azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl,      diazabicyclo [3.1.1 ]heptanyl,diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or(Ral)mi indicates that ring W2 is optionally substituted with ml Ral substituents, with each Ral independently representing deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R8a-R7a-, where R7a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R8a represents halogen, R9aR10aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl; orW1 represented by the structure of the following formula:(Ra3)m3   (Ra2)m2wherein each ring W3 is the same or different and independently represents 4- to 20membered nitrogen-containing heterocyclylene, e.g.,piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1 ]heptanylene, azabicyclo[2.2.1 ]heptanylene, azabicyclo[3.2.1 ]octanylene, azabicyclo[2.2.2]octanylene,                                diazabicyclo [3.1.1 ]heptanylene,diazabicyclo[2.2.1]heptanylene,                            diazabicyclo[3.2.1]octanylene,diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, ort represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, where Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R13a and R14a are the same or different and each independently represent hydrogen or Ci-3 alkyl; andring W4 represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, e.g.,piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo [3. l.l]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1 ]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo [3.1.1 ]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,l,3]oxadiazolyl, benzo[2,l,3]thiadiazolyl, benzo[l,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[l,5-a]pyridyl, pyrazolo[l,5-a]pyrimidinyl, imidazo[l,2-a]pyridyl, lH-pyrrolo[3,2-b]pyridyl, lH-pyrrolo[2,3-b]pyridyl, pyrrolo[2,l-b]thiazolyl, or imidazo[2,l-b]thiazolyl; or(Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl;wherein ml, m2, and m3 each independently represent an integer of 0-20.

5. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein R represents the followinggroups:chlorine, bromine, iodine, hydroxy, -N3, sulfonate, e.g., methanesulfonyloxy (MsO-),trifluoromethanesulfonyloxy (TfO-), p-toluenesulfonyloxy (TsO-), NH2, or6. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein Rs and Re each independently represent:hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl,wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, S(0), S(0)2, S(0)2NH, NHS(O)2, 0C(0), C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene),heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; anda hydrogen atom of methyl and hydrogen atom of one or more CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof.

7. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein R and Rs together with the carbon atom to which they are connected form carbonyl group.

8. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 1-2 and 6-7, wherein Re represents the structure of the following formula:-Ci-30 alkyl;-(C(Ra4)(Ra5)h^-(C(Ra4)(Ra5))nHRc-(C(R^-(C(Ra4)(Ra5))nHRc-(C(Ra6)(Ra7)k^-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))nHRd-(C^-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-(Rd-(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))nHR^^-(C(Ra4)(Ra5))nHRc-(C^-(C(Ra4)(Ra5))ni-(Rd-Rc-(C(Ra6)(Ra7))n2)m4-H; or-(C(Ra4)(Ra5))nHRd-(C^wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, 0C(0), S(0), S(0)2, S(O)2NH, NHS(O)2, C(0)N(Re), N(Re)C(0), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C5-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 5- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene,arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;a hydrogen atom of one or more CH2 of C1-30 alkyl is optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated Ci-6 alkyl-C(O)NH-; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

9. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 8, wherein Re represents the structure of the following formula:-(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))nHO-(CT^-(C(Ra4)(Ra5))nHO-(C(Ra6)(^^-(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))nl-(N(Re)-(C(Ra6)(Ra7))n2W-(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-(N(Re)-(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))ni-(C(O)N(Re)-(^-(C(Ra4)(Ra5))nl-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(^^^-(C(Ra4)(Ra5))nHC(O)N(Rc)-(a^(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))nHC(O)N(R^-(C(Ra4)(Ra5))ni-C(O)N(Re)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H;-(C(Ra4)(Ra5))ni-(N(Re)C(O)-(^-(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H;-(C(Ra4)(Ra5))nHN(Re)C(0)-O^-(C(Ra4)(Ra5))ni-N(Re)C(O)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H;-(C(Ra4)(Ra5)^-(C(Ra4)(Ra5))ni-C(O)-(C(Ra6)(Ra7))n2-H;-(C(Ra4)(Ra5))ni-(arylene-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))nHarylene-(a^-(C(Ra4)(Ra5))ni-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-(heterocyclylene-(C(Ra8)(Ra9))n3)m5-H;-(C(Ra4)(Ra5))ni-(heteroarylene^-(C(Ra4)(Ra5))nHhelero^^^-(C(Ra4)(Ra5))ni-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-H; or-(C(Ra4)(Ra5))nHcycloalky^^wherein each Re independently represents H or Ci-6 alkyl;the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated Ci-6 alkyl-C(O)NH-; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

10. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Re represents the following group:H, fluorine, chlorine, bromine, iodine, -CH3, -CH2-CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2)io-CH3, -(CH2)ii-CH3, -(CH2)i2-CH3, -(CH2)i3-CH3, -(CH2)i4-CH3, -(CH2)i5-CH3, -(CH2)i6-CH3, -(CH2)i7-CH3, -(CH2)i8-CH3, -(CH2)19-CH3, -(CH2)20-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)25-CH3, -(CH2)29-CH3;-CH2-O-CH3, -CH2-O-CH2-CH3, -CH2-O-(CH2)2-CH3, -(CH2)i-O-(CH2)3-CH3, -(CH2)i-O-(CH2)4-CH3, -(CH2)i-O-(CH2)5-CH3, -(CH2)i-O-(CH2)6-CH3, -(CH2)i-O-(CH2)7-CH3, -(CH2)i-O-(CH2)8-CH3, -(CH2)i-O-(CH2)9-CH3, -(CH2)i-0-(CH2)io-CH3, -(CH2)2-O-CH3, -(CH2)2-O-CH2-CH3, -(CH2)2-O-(CH2)2-CH3, -(CH2)2-O-(CH2)3-CH3, -(CH2)2-O-(CH2)4-CH3, -(CH2)2-O-(CH2)5-CH3, -(CH2)2-O-(CH2)6-CH3, -(CH2)2-O-(CH2)7-CH3, -(CH2)2-O-(CH2)8-CH3, -(CH2)2-O-(CH2)9-CH3, -(CH2)2-0-(CH2)io-CH3, -(CH2)2-O-(CH2)11-CH3, -(CH2)2-O-(CH2)i2-CH3, -(CH2)3-O-CH3, -(CH2)3-O-CH2-CH3, -(CH2)3-O-(CH2)2-CH3, -(CH2)3-O-(CH2)3-CH3, -(CH2)3-O-(CH2)4-CH3, -(CH2)3-O-(CH2)5-CH3, -(CH2)3-O-(CH2)6-CH3, -(CH2)3-O-(CH2)7-CH3, -(CH2)4-O-CH3, -(CH2)4-O-CH2-CH3, -(CH2)4-O-(CH2)2-CH3, -(CH2)4-O-(CH2)3-CH3, -(CH2)4-O-(CH2)4-CH3, -(CH2)4-O-(CH2)5-CH3, -(CH2)4-O-(CH2)6-CH3, -(CH2)5-O-CH3, -(CH2)5-O-CH2-CH3, -(CH2)5-O-(CH2)2-CH3, -(CH2)5-O-(CH2)3-CH3, -(CH2)5-O-(CH2)4-CH3, -(CH2)5-O-(CH2)5-CH3, -(CH2)6-O-CH3, -(CH2)6-O-CH2-CH3, -(CH2)6-O-(CH2)2-CH3, -(CH2)6-O-(CH2)3-CH3, -(CH2)6-O-(CH2)4-CH3, -(CH2)7-O-CH3, -(CH2)7-O-CH2-CH3, -(CH2)7-O-(CH2)2-CH3, -(CH2)7-O-(CH2)3-CH3, -(CH2)8-O-CH3, -(CH2)8-O-CH2-CH3, -(CH2)8-O-(CH2)2-CH3, -CH(CH3)-O-CH3, -CH(CH3)-O-CH2-CH3, -CH(CH3)-O-(CH2)2-CH3, -CH(CH3)-O-(CH2)3-CH3, -CH(CH3)-O-(CH2)4-CH3, -CH(CH3)-O-(CH2)5-CH3, -CH(CH3)-O-(CH2)6-CH3, -CH(CH3)-O-(CH2)7-CH3, -CH(CH3)-O-(CH2)8-CH3, -CH(CH3)-O-(CH2)9-CH3, -CH(CH3)-0-(CH2)io-CH3, -ch2-(O(CH2)2)i-OCH2CH3, -CH2-(O(CH2)2)2-OCH2CH3, -CH2-(O(CH2)2)3-OCH2CH3, -CH2-(O(CH2)2)4-OCH2CH3, -CH2-(O(CH2)2)5-OCH2CH3, -CH2-(O(CH2)2)6-OCH2CH3, -CH2-(O(CH2)2)7-OCH2CH3, -CH2-(O(CH2)2)8-OCH2CH3, -CH2-(O(CH2)2)9-OCH2CH3, -CH2-(0(CH2)2)io-OCH2CH3, -CH2-(O(CH2)2)i-OCH3, -CH2-(O(CH2)2)2-OCH3, -CH2-(O(CH2)2)3-OCH3, -CH2-(O(CH2)2)4-OCH3, -CH2-(O(CH2)2)5-OCH3, -CH2-(O(CH2)2)6-OCH3, -CH2-(O(CH2)2)7-OCH3, -CH2-(O(CH2)2)8-OCH3, -CH2-(O(CH2)2)9-OCH3, -CH2-(0(CH2)2)io-OCH3, -(CH2)2-(O(CH2)2)i-OCH2CH3, -(CH2)2-(O(CH2)2)2-OCH2CH3, -(CH2)2-(O(CH2)2)3-OCH2CH3, -(CH2)2-(O(CH2)2)4-OCH2CH3, -(CH2)2-(O(CH2)2)5-OCH2CH3, -(CH2)2-(O(CH2)2)6-OCH2CH3, -(CH2)2-(O(CH2)2)7-OCH2CH3, -(CH2)2-(O(CH2)2)8-OCH2CH3, -(CH2)2-(O(CH2)2)9-OCH2CH3, -(CH2)2-(0(CH2)2)io-OCH2CH3, -(CH2)3-(O(CH2)2)i-OCH2CH3, -(CH2)3-(O(CH2)2)2-OCH2CH3, -(CH2)3-(O(CH2)2)3-OCH2CH3, -(CH2)3-(O(CH2)2)4-OCH2CH3, -(CH2)3-(O(CH2)2)5-OCH2CH3, -(CH2)3-(O(CH2)2)6-OCH2CH3, -(CH2)3-(O(CH2)2)7-OCH2CH3, -(CH2)3-(O(CH2)2)8-OCH2CH3, -(CH2)3-(O(CH2)2)9-OCH2CH3, -(CH2)3-(0(CH2)2)io-OCH2CH3, -(CH2)4-(O(CH2)2)i-OCH2CH3, -(CH2)4-(O(CH2)2)2-OCH2CH3, -(CH2)4-(O(CH2)2)3-OCH2CH3, -(CH2)4-(O(CH2)2)4-OCH2CH3, <CH2MO(CH2)2)5-OCH2CH3, -(CH2)4-(O(CH2)2)6-OCH2CH3, -(CH2)4-(O(CH2)2)7-OCH2CH3, <CH2MO(CH2)2)8-OCH2CH3, -(CH2)4-(O(CH2)2)9-OCH2CH3, -(CH2)4-(0(CH2)2)io-OCH2CH3, -CH2-(O(CH2)3)i-OCH2CH2CH3, -CH2-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)3)4-OCH2CH2CH3, -CH2-(O(CH2)3)5-OCH2CH2CH3, -CH2-(O(CH2)3)6-OCH2CH2CH3, -CH2-(O(CH2)3)7-OCH2CH2CH3, -CH2-(O(CH2)3)8-OCH2CH2CH3, -CH2-(O(CH2)3)9-OCH2CH2CH3,   -CH2-(0(CH2)3)io-OCH2CH2CH3,   -(CH2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)2-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)3)3-OCH2CH2CH3, -(CH2)2-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)6-OCH2CH2CH3, -(CH2)2-(O(CH2)3)7-OCH2CH2CH3, -(CH2)2-(O(CH2)3)8-OCH2CH2CH3, -(CH2)3-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)3)3-OCH2CH2CH3, -(CH2)3-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)6-OCH2CH2CH3, -(CH2)3-(O(CH2)3)7-OCH2CH2CH3, -(CH2)3-(O(CH2)3)8-OCH2CH2CH3, -CH2-O-(CH2)2-O-(CH2)2-CH3, -CH2-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -CH2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,    -CH2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-O-(CH2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3,   -(CH2)2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,   -(CH2)2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-O-(CH2)2-O-(CH2)2CH3, -(CH2)3-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3,   -(CH2)3-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,   -(CH2)3-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3,   -CH2-O-(CH2)3-O-CH2CH3, -CH2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -CH2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -ch2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -CH2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)2-O-(CH2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)3-O-(CH2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)3-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)3-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -CH2-O-(CH2)2-O-CH3, -(CH2)2-O-(CH2)2-O-CH3, -(CH2)2-(O(CH2)2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)3-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)4-O-(CH2)2CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)4CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)5CH3, -(CH2)i-N(Re)-CH3, -(CH2)i-N(Re)-(CH2)i-CH3, -(CH2)i-N(Re)-(CH2)2-CH3, -(CH2)i-N(Re)-(CH2)3-CH3, -(CH2)i-N(Re)-(CH2)4-CH3, -(CH2)i-N(Re)-(CH2)5-CH3, -(CH2)i-N(Re)-(CH2)6-CH3, -(CH2)i-N(Re)-(CH2)7-CH3, -(CH2)i-N(Re)-(CH2)8-CH3, -(CH2)i-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-CH3, -(CH2)2-N(Re)-(CH2)i-CH3, -(CH2)2-N(Re)-(CH2)2-CH3, -(CH2)2-N(Re)-(CH2)3-CH3, -(CH2)2-N(Re)-(CH2)4-CH3, -(CH2)2-N(Re)-(CH2)5-CH3, -(CH2)2-N(Re)-(CH2)6-CH3, -(CH2)2-N(Re)-(CH2)7-CH3, -(CH2)2-N(Re)-(CH2)8-CH3, -(CH2)2-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-(CH2)io-CH3, -(CH2)2-N(Re)-(CH2)ii-CH3, -(CH2)3-N(Re)-CH3, <CH2)3-N(Re)-(CH2)i-CH3, -(CH2)3-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-CH3, -(CH2)4-N(Re)-(CH2)i-CH3, -(CH2)4-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-CH3, -(CH2)5-N(Re)-(CH2)i-CH3, -(CH2)5-N(Re)-(CH2)2-CH3, -(CH2)5-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-(CH2)4-CH3, -(CH2)6-N(Re)-CH3, -(CH2)6-N(Re)-(CH2)i-CH3, -(CH2)6-N(Re)-(CH2)2-CH3, -(CH2)7-N(Re)-CH3, -(CH2)7-N(Re)-(CH2)i-CH3, -(CH2)7-N(Re)-(CH2)2-CH3, -(CH2)8-N(Re)-CH3, -(CH2)8-N(Re)-(CH2)i-CH3, -(CH2)8-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-CH3, -CH(CH3)-N(Re)-(CH2)i-CH3, -CH(CH3)-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-(CH2)3-CH3, -CH(CH3)-N(Re)-(CH2)4-CH3, -CH(CH3)-N(Re)-(CH2)5-CH3, -CH(CH3)-N(Re)-(CH2)6-CH3, -CH(CH3)-N(Re)-(CH2)7-CH3, -CH(CH3)-N(Re)-(CH2)8-CH3, -CH(CH3)-N(Re)-(CH2)9-CH3, -CH2C(O)NHCH3, -(CH2)2C(O)NHCH2CH3, -(CH2)2C(O)NH(CH2)2-CH3,    -(CH2)2C(O)NH(CH2)3-CH3,    -(CH2)2C(O)NH(CH2)4-CH3,    -(CH2)3C(O)NH(CH2)2-CH3,    -(CH2)3C(O)NH(CH2)3-CH3,    -(CH2)4C(O)NH(CH2)3-CH3,    -(CH2)5C(O)NH(CH2)4-CH3,    -(CH2)6C(O)NH(CH2)6-CH3,    -(CH2)6C(O)NH(CH2)5-CH3,    -(CH2)7C(O)NH(CH2)6-CH3,    -(CH2)8C(O)NH(CH2)7-CH3,   U-(CH2)9C(O)NH(CH2)8-CH3,   -(CH2)ioC(0)NH(CH2)9-CH3,   -(CH2)2C(O)NH(CH2)2-O-CH2-CH3,     -CH2NHC(O)CH3,     -(CH2)2NHC(O)CH2CH3,     -(CH2)2NHC(O)(CH2)2-CH3,    -(CH2)2NHC(O)(CH2)3-CH3,    -(CH2)2NHC(O)(CH2)4-CH3,    -(CH2)3NHC(O)(CH2)2-CH3,    -(CH2)3NHC(O)(CH2)3-CH3,    -(CH2)4NHC(O)(CH2)3-CH3,    -(CH2)5NHC(O)(CH2)4-CH3,    -(CH2)6NHC(O)(CH2)6-CH3,    -(CH2)6NHC(O)(CH2)5-CH3,    -(CH2)7NHC(O)(CH2)6-CH3,    -(CH2)8NHC(O)(CH2)7-CH3,    -(CH2)9NHC(O)(CH2)8-CH3,    -(CH2)ioNHC(0)(CH2)9-CH3, -(CH2)4NHC(O)(CH2)7-CH3, -(CH2)2NHC(O)(CH2)2-O-CH2-CH3, -(CH2)4NHC(O)CH3, -CH2-piperidinylene-CH3, -CH2-piperidinylene-CH2-CH3, -CH2-piperidinylene-(CH2)2-CH3, -CH2-piperidinylene-(CH2)3-CH3, -CH2-piperidinylene-(CH2)4-CH3, -CH2-piperidinylene-(CH2)5-CH3, -CH2-piperidinylene-(CH2)6-CH3, -CH2-piperidinylene-(CH2)7-CH3, -(CH2)2-piperidinylene-CH3, -(CH2)2-piperidinylene-CH2-CH3, -(CH2)2-piperidinylene-(CH2)2-CH3, -(CH2)2-piperidinylene-(CH2)3-CH3, -(CH2)2-piperidinylene-(CH2)4-CH3, -(CH2)2-piperidinylene-(CH2)s-CH3, -(CH2)2-piperidinylene-(CH2)6-CH3, -(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)3-piperidinylene-CH3, -(CH2)3-piperidinylene-CH2-CH3, -(CH2)3-piperidinylene-(CH2)2-CH3, -(CH2)3-piperidinylene-(CH2)3-CH3, -(CH2)3-piperidinylene-(CH2)4-CH3, -(CH2)3-piperidinylene-(CH2)5-CH3, -(CH2)3-piperidinylene-(CH2)6-CH3, -(CH2)3-piperidinylene-(CH2)7-CH3, -(CH2)4-piperidinylene-CH3, -(CH2)4-piperidinylene-CH2-CH3, -(CH2)4-piperidinylene-(CH2)2-CH3, -(CH2)4-piperidinylene-(CH2)3-CH3, -(CH2)4-piperidinylene-(CH2)4-CH3, -(CH2)4-piperidinylene-(CH2)5-CH3, -(CH2)4-piperidinylene-(CH2)6-CH3, -(CH2)4-piperidinylene-(CH2)7-CH3, -(CH2)5-piperidinylene-CH3, -(CH2)5-piperidinylene-CH2-CH3, -(CH2)5-piperidinylene-(CH2)2-CH3, -(CH2)5-piperidinylene-(CH2)3-CH3, -(CH2)5-piperidinylene-(CH2)4-CH3, -(CH2)5-piperidinylene-(CH2)5-CH3, -(CH2)s-piperidinylene-(CH2)6-CH3, -(CH2)5-piperidinylene-(CH2)7-CH3, -(CH2)6-piperidinylene-CH3, -(CH2)6-piperidinylene-CH2-CH3, -(CH2)6-piperidinylene-(CH2)2-CH3, -(CH2)6-piperidinylene-(CH2)3-CH3, -(CH2)6-piperidinylene-(CH2)4-CH3, -(CH2)6-piperidinylene-(CH2)5-CH3, -(CH2)6-piperidinylene-(CH2)6-CH3, -(CH2)6-piperidinylene-(CH2)7-CH3, -(CH2)7-piperidinylene-CH3, -(CH2)7-piperidinylene-CH2-CH3, -(CH2)7-piperidinylene-(CH2)2-CH3, -(CH2)7-piperidinylene-(CH2)3-CH3, -(CH2)7-piperidinylene-(CH2)7-CH3, -(CH2)8-piperidinylene-CH3, -(CH2)8-piperidinylene-CH2-CH3, -(CH2)8-piperidinylene-(CH2)2-CH3, -(CH2)8-piperidinylene-(CH2)3-CH3, -(CH2)8-piperidinylene-(CH2)4-CH3, -(CH2)8-piperidinylene-(CH2)5-CH3, -(CH2)8-piperidinylene-(CH2)6-CH3, -(CH2)8-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH2-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)2-CH3,(CH2)2-piperidinylene-(CH2)4-CH3,(CH2)2-piperidinylene-(CH2)6-CH3,-CH2-N(Re)-(CH2)2-piperidinylene-(CH2)3-CH3,-CH2-N(Re)-(CH2)2-piperidinylene-(CH2)5-CH3,-CH2-N(Re)--CH2-N(Re)--CH2-N(Re)-(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3, piperidinylene-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)3-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)5-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)3-N(Re)-CH2-piperidinylene-CH2-CH3,piperidinylene-(CH2)2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)7-CH3,piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-CH3,piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3,-(CH2)4-N(Re)-CH2-piperidinylene-CH2-CH3,-(CH2)4-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)5-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)6-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)7-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-CH2-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH2)3-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH2)5-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH^^^-(CH2)2-N(Re)-CH2--(CH2)2-N(Re)-CH2--(CH2)3-N(Re)-CH2--(CH2)3-N(Re)-CH2--(CH2)4-N(Re)-CH2--(CH2)4-N(Re)-CH2--(CH2)5-N(Re)-CH2--(CH2)6-N(Re)-CH2--(CH2)7-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--CH2-piperazinylene-CH3, -CH2-piperazinylene-CH2-CH3, -CH2-piperazinylene-(CH2)2-CH3, -CH2-piperazinylene-(CH2)3-CH3, -CH2-piperazinylene-(CH2)4-CH3, -CH2-piperazinylene-(CH2)s-CH3, -CH2-piperazinylene-(CH2)6-CH3, -CH2-piperazinylene-(CH2)7-CH3, -(CH2)2-piperazinylene-CH3, -(CH2)2-piperazinylene-CH2-CH3, -(CH2)2-piperazinylene-(CH2)2-CH3, -(CH2)2-piperazinylene-(CH2)3-CH3, -(CH2)2-piperazinylene-(CH2)4-CH3, -(CH2)2-piperazinylene-(CH2)s-CH3, -(CH2)2-piperazinylene-(CH2)6-CH3, -(CH2)2-piperazinylene-(CH2)7-CH3, -(CH2)3-piperazinylene-CH3, -(CH2)3-piperazinylene-CH2-CH3, -(CH2)3-piperazinylene-(CH2)2-CH3, -(CH2)3-piperazinylene-(CH2)3-CH3, -(CH2)3-piperazinylene-(CH2)4-CH3, -(CH2)3-piperazinylene-(CH2)5-CH3, -(CH2)3-piperazinylene-(CH2)6-CH3, -(CH2)3-piperazinylene-(CH2)7-CH3, -(CH2)4-piperazinylene-CH3, -(CH2)4-piperazinylene-CH2-CH3, -(CH2)4-piperazinylene-(CH2)2-CH3, -(CH2)4-piperazinylene-(CH2)3-CH3, -(CH2)4-piperazinylene-(CH2)4-CH3, -(CH2)4-piperazinylene-(CH2)5-CH3, -(CH2)4-piperazinylene-(CH2)6-CH3, -(CH2)4-piperazinylene-(CH2)7-CH3, -(CH2)5-piperazinylene-CH3, -(CH2)s-piperazinylene-CH2-CH3, -(CH2)5-piperazinylene-(CH2)2-CH3, -(CH2)5-piperazinylene-(CH2)3-CH3, -(CH2)s-piperazinylene-(CH2)4-CH3, -(CH2)s-piperazinylene-(CH2)5-CH3, -(CH2)s-piperazinylene-(CH2)6-CH3, -(CH2)s-piperazinylene-(CH2)7-CH3, -(CH2)6-piperazinylene-CH3, -(CH2)6-piperazinylene-CH2-CH3, -(CH2)6-piperazinylene-(CH2)2-CH3, -(CH2)6-piperazinylene-(CH2)3-CH3, -(CH2)6-piperazinylene-(CH2)4-CH3, -(CH2)6-piperazinylene-(CH2)s-CH3, -(CH2)6-piperazinylene-(CH2)6-CH3, -(CH2)6-piperazinylene-(CH2)7-CH3, -(CH2)7-piperazinylene-CH3, -(CH2)7-piperazinylene-CH2-CH3, -(CH2)7-piperazinylene-(CH2)2-CH3, -(CH2)7-piperazinylene-(CH2)3-CH3, -(CH2)7-piperazinylene-(CH2)7-CH3, -(CH2)8-piperazinylene-CH3, -(CH2)8-piperazinylene-CH2-CH3, -(CH2)8-piperazinylene-(CH2)2-CH3, -(CH2)8-piperazinylene-(CH2)3-CH3, -(CH2)8-piperazinylene-(CH2)4-CH3, -(CH2)8-piperazinylene-(CH2)s-CH3, -(CH2)8-piperazinylene-(CH2)6-CH3, or -(CH2)8-piperazinylene-(CH2)7-CH3;wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof;a hydrogen atom of CH3 of the groups and a hydrogen atom of one or more CH2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;each Re independently represents H or C1-6 alkyl; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

11. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9, which is selected from:3-(5-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(chloromethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(iodomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(aminomethyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(aminomethyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(aminomethyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;(2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl 4-methylbenzenesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl methanesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl trifluoromethanesulfonate;3-(5-(bromomethyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(bromomethyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(bromomethyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-5-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-bromo-5-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-bromo-5-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-5-((piperazin-l-yl-2,2,3,3,5,5,6,6-d8)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(5-((2,6-dimethylpiperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3,5-dimethylpiperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-chloro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-1 -oxo-5-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-chloro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3 -(4-bromo-1 -oxo-5-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-chloro-l-oxo-5-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3 -(6-bromo-1 -oxo-5-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(chloromethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(iodomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-fluoro-4-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-4-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-4-(hydroxymethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(aminomethyl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(aminomethyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(aminomethyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;(2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-4-yl)methyl 4-methylbenzenesulfonate;(2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-4-yl)methyl methanesulfonate;(2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-4-yl)methyl trifluoromethanesulfonate;3-(4-(bromomethyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(bromomethyl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(bromomethyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-4-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-bromo-4-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-bromo-4-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((3,6-diazabicyclo [3.1.1 ]heptan-3 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((3,6-diazabicyclo [3.1.1 ]heptan-6-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(l-oxo-4-((piperazin-l-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-((2,6-dimethylpiperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((3,5-dimethylpiperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-l-oxo-4-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-chloro-l-oxo-4-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(5-fluoro-l-oxo-4-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(5-chloro-l-oxo-4-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(5 -bromo-1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-l-oxo-4-(piperazin-l-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-chloro-1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-bromo-1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((R)-3 -aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((S)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-5-(piperidin-4-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3 -(5-(azetidin-3 -ylmethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((R)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((S)-3-aminopiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-((4-aminopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione3 -(1 -oxo-4-(piperazin-1 -ylmethyl)isoindolin-2-yl)piperidine-2,6-dione;3 -(4-(azetidin-3 -ylmethyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-(iodomethyl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-(hydroxymethyl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(hydroxymethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(hydroxymethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(hydroxymethyl)isoindoline-1,3-dione;5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;6-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)methyl 4-methylbenzenesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)methyl methanesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)methyl trifluoromethanesulfonate;6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;5-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-((piperazin-l-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindoline-1,3-dione;5-((2,6-dimethylpiperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-((3,5-dimethylpiperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-fluoro-6-(piperazin-l-ylmethyl)isoindoline- 1,3-dione;4-chloro-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-bromo-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-chloro-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-l-ylmethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione;5-chloro-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione;5-bromo-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-(chloromethyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(iodomethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(hydroxymethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-4-(hydroxymethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-4-(hydroxymethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-fluoro-7-(hydroxymethyl)isoindoline- 1,3-dione;4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)methyl 4-methylbenzenesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)methyl methanesulfonate;(2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)methyl trifluoromethanesulfonate;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;4-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-l,3-dione;4-((3,6-diazabicyclo[3.1.1 ]heptan-6-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-1,3 -dione;4-((3,8-diazabicyclo[3.

2. l]octan-8-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline- 1,3-dione;4-((3,8-diazabicyclo[3.

2. l]octan-3-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline- 1,3-dione;4-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-l,3-dione;4-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline- 1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((piperazin-l-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindoline-1,3-dione;4-((2,6-dimethylpiperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-((3,5-dimethylpiperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-chloro-2-(2,6-dioxopiperidin-3-yl)-7-(piperazin-l-ylmethyl)isoindoline-1,3-dione;4-bromo-2-(2,6-dioxopiperidin-3-yl)-7-(piperazin-l-ylmethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperi din-3-yl)-5-fluoro-4-(piperazin-l-ylmethyl)isoindoline- 1,3-dione;5-chloro-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-l-ylmethyl)isoindoline-1,3-dione;5-bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-l-ylmethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-4-(piperazin-l-ylmethyl)isoindoline-1,3-dione;6-chloro-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-l-ylmethyl)isoindoline-1,3-dione;6-bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-l-ylmethyl)isoindoline-1,3-dione;5-(((R)-3-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-(((S)-3-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;5-((4-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-l-ylmethyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-ylmethyl)isoindoline-1,3-dione;5-(azetidin-3-ylmethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(((R)-3-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(((S)-3-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l, 3-dione;4-((4-aminopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;4-(azetidin-3-ylmethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;(E)-4-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid;(E)-4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid;(E)-4-(4-((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enoic acid;(E)-4-(4-((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-4-yl)methyl)piperazin-1 -yl)but-2-enoic acid;3-(5-((4-(3 -hydroxypropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(3-hydroxypropyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((4-(3-hydroxypropyl)piperazin-l-yl)methyl)isoindoline-l,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((4-(3-hydroxypropyl)piperazin-l-yl)methyl)isoindoline-l,3-dione;3-(5-((4-(3 -bromopropyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(3-bromopropyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(3 -bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3 -dione;4-((4-(3 -bromopropyl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3 -dione;3-(5-((4-hydroxypiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-hydroxypiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((4-hydroxypiperidin-l-yl)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((4-hydroxypiperidin-l-yl)methyl)isoindoline-1,3-dione;3 -(5-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-bromopiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-bromopiperidin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -di one;4-((4-bromopiperidin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;3-(5-(((2-bromoethyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((2-bromoethyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;5-(((2-bromoethyl)(methyl)amino)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(((2-bromoethyl)(methyl)amino)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;3-(5-((methyl(piperidin-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((methyl(piperidin-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((methyl(piperidin-4-yl)amino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((methyl(piperidin-4-yl)amino)methyl)isoindoline-1,3-dione;3-(1 -oxo-5-((4-(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(1 -oxo-4-((4-(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3 -yl)-5-((4-(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindoline-1,3 -di one;2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindoline-1,3-dione;3-(l-oxo-5-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-4-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3-yl)-5-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-((4-(piperidin-4-yl)piperazin-l-yl)methyl)isoindoline- 1,3-dione;3-(l-oxo-5-((4-phenylpiperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-4-((4-phenylpiperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((4-phenylpiperazin-l-yl)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((4-phenylpiperazin-l-yl)methyl)isoindoline-1,3-dione;3 -(5-((4-(4-bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(4-bromophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(4-bromophenyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-((4-(4-bromophenyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;3-(1 -oxo-5-((4-(pyridazin-3 -yl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(1 -oxo-4-((4-(pyridazin-3 -yl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3-yl)-5-((4-(pyridazin-3-yl)piperazin-l-yl)methyl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-((4-(pyridazin-3-yl)piperazin-l-yl)methyl)isoindoline- 1,3-dione;3-(5-((4-(6-chloropyridazin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(6-chloropyridazin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(6-chloropyridazin-3-yl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;4-((4-(6-chloropyridazin-3-yl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione;1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)-3 -fluoropiperidin-4-yl methanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-4-yl)methyl)-3 -fluoropiperidin-4-yl methanesulfonate;1-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-4-yl)methy 1)-3 -fluoropiperi din-4-yl methanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-5-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate;1 -((2-(2,6-dioxopiperi din-3 -yl)-1,3 -dioxoisoindolin-4-yl)methyl)piperidin-3 -yl trifluoromethanesulfonate;3-(5-((4-(6-aminopyridin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(6-aminopyridin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(6-aminopyri din-3 -yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;4-((4-(6-aminopyri din-3 -yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3-dione;3 -(5-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;4-((4-(azetidin-3 -yl)piperazin-1 -yl)methyl)-2-(2,6-dioxopiperidin-3 -yl)isoindoline-1,3 -dione;3-(l-oxo-5-((3-(piperazin-l-yl)azetidin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(1 -oxo-4-((3-(piperazin-1 -yl)azetidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-((3 -(piperazin-1 -yl)azetidin-1 -yl)methyl)isoindoline-1,3 -di one;2-(2,6-dioxopiperi din-3 -y 1)-4-((3 -(piperazin-1 -yl)azetidin-1 -yl)methyl)isoindoline-1,3 -di one;3-(5-((4-methylpiperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-methylpiperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((4-methylpiperazin-l-yl)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((4-methylpiperazin-l-yl)methyl)isoindoline-1,3-dione;3-(5-((4-(difluoromethyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(difluoromethyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(difluoromethyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(difluoromethyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(l-oxo-5-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-4-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((piperidin-4-ylamino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((piperidin-4-ylamino)methyl)isoindoline-1,3-dione;3-(5-((4-(2-aminoethyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-(2-aminoethyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;5-((4-(2-aminoethyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperi din-3-yl)isoindoline-1,3-dione; 4-((4-(2-aminoethyl)piperazin-l-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione; 3-(l-oxo-5-((4-propylpiperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-4-((4-propylpiperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3-yl)-5-((4-propylpiperazin-l-yl)methyl)isoindoline- 1,3-dione;2-(2,6-dioxopiperi din-3-yl)-4-((4-propylpiperazin-l-yl)methyl)isoindoline- 1,3-dione;3-(5-(((2-hydroxyethyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((2-hydroxyethyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((2-hydroxyethyl)amino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(((2-hydroxyethyl)amino)methyl)isoindoline-1,3-dione;1 -((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxylic acid;1 -((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)methyl)piperidine-4-carboxylic acid;1 -((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-5-yl)methyl)piperidine-4-carboxylic acid;1 -((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)methyl)piperidine-4-carboxylic acid; r-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-[l,4'-bipiperidine]-4-carboxylic acid;r-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)methyl)-[l,4'-bipiperidine]-4-carboxylic acid;1 '-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-5-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxylic acid;1 '-((2-(2,6-dioxopiperidin-3 -yl)-1,3 -dioxoisoindolin-4-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxylic acid;3-(5-((4-ethynylpiperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-((4-ethynylpiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-((4-ethynylpiperidin-l-yl)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((4-ethynylpiperidin-l-yl)methyl)isoindoline-1,3-dione;3-(1 -oxo-5-((3 -(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(1 -oxo-4-((3 -(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperi din-3 -y 1)-5-((3 -(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindoline-1,3 -di one; 2-(2,6-dioxopiperi din-3 -y 1)-4-((3 -(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindoline-1,3 -di one; 3-(5-(((4-methylpiperidin-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((4-methylpiperidin-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline-1,3-dione;3-(5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-l-oxoisoindoline-4-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindoline-4-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindoline-4-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l,3-dioxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindoline-5-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-l,3-dioxoisoindoline-4-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l,3-dioxoisoindoline-4-carbaldehyde;2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l,3-dioxoisoindoline-4-carbaldehyde;3-(4-bromo-6-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-bromo-6-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-6-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(bromomethyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(bromomethyl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(bromomethyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-bromo-7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-bromo-7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-bromo-7-(bromomethyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-(bromomethyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-(bromomethyl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-(bromomethyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione;5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione;4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; and4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione.

12. A compound of Formula (II)PBM-Rf-LIN-ULMFormula (II)or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,wherein PBM-Rf- represents a targeting moiety capable of binding protein, ULM represents a E3 ubiquitin ligase ligand moiety, LIN is a linker moiety, and PBM-Rf- is covalently bonded to ULM through LIN;ULM represents the structure of Formula (ULM):Formula (ULM)wherein A represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Rb)n indicates that the benzene ring is optionally substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6alkynyl;n represents an integer of 0, 1, 2 or 3;LIN represents the structure of the following formula:wherein R5 and Re are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branchedC2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(0), C(0)0, S(0), S(0)2, S(0)2NH, NHS(O)2, 0C(0), C(O)N(Re), N(Re)C(O), or N(Re)C(0)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;Rf represents a bond, -0-, -N(Rg)-, -NHC(0)-Rh-W5-*, -C(0)NH-Rh-W5-*, -NHC(0)-W5-*, -C(0)NH-W5-*, -NHC(O)-*, -C(0)NH-*, -0-Rh-W5-*, -0-W5-*, -0-Rh-N(Ri)-*, -N(Rg)-Rh-N(Ri)-*, -W5-, -W5-N(Rg)-*, -N(Rg)-W5-*, -N(Rg)-W5-N(R0-*, -Rh-W5-*, -Rh-C(0)-W5-*, -C(0)-W5-*, -Rh-C(O)NH-Rj-W5-*, -Rh-NHC(O)-Rj-W5-*, -Rh-C(0)NH-*, -Rh-NHC(0)-*, -Rh-, -Rh-N(Ri)-*, or = w5—*wherein W5 represents the structure of the following formula:(Ra3)m3 (Ra2)m2wherein each ring W6 is the same or different and each independently represents nitrogencontaining heterocyclylene, tl represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, where Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m2 represents an integer of 0-20;each ring W7 is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, (Ra3)m3 indicates thateach ring W7 is independently optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; andRg and Ri each independently represent hydrogen or C1-6 alkyl, Rh and Rj each independently represent optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and symbol * indicates the point of attachment to LIN;wherein when PBM represents the structure of the following formula:X—IM    IM—fand simultaneously -Rf-LIN- represents      '—'    , where symbol ** indicates the point ofattachment to ULM, (Rb)n indicates that benzene ring of Formula (ULM) is substituted with 1, 2, or 3 Rb, with each Rb being the same or different and each independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl, or C2-6 alkynyl;with the proviso that the following compounds are excluded:3-(4-((3-(4-amino-3-(4-phenoxypheny 1)-1 H-pyrazolo [3,4-<7]pyrimi din- l-yl)piperi din-1-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -y 1)-3 -oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;N-(5-(3,5-difluorobenzyl)-1 H-indazol-3 -yl)-4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1,3-dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-l-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide;2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-l-yl)imidazo[ 1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)methyl)isoindoline-1,3-dione; and2-(2,6-dioxopiperi din-3 -y 1)-5-((3 -(4-(6-(6-(2-(3 -fluorophenyl)pyrrolidin-1 -yl)imidazo [1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)isoindoline-1,3-dione.

13. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein the PBM-Rf- represents a small molecule ligand targeting epidermal growth factor receptor (EGFR), Cyclin-dependent kinase 4 / 6 (CDK4 / 6), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), fibroblast growth factor receptors (FGFRs), proto-oncogene tyrosine-protein kinase receptor RET (RET), Focal adhesion kinase (FAK), breakpoint cluster region (BCR)-Abelson leukemia virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), Androgen receptor (AR), Estrogen receptor (ER), Bromodomain and extra-terminal domain protein (BET), Interleukin-1 receptor-associated kinase 4 (IRAK4), Cyclin-dependent kinase 9 (CDK9), Histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic receptor tyrosine kinase (NTRK), Src homology 2 domain containing protein tyrosine phosphatase (SHP2), Poly (ADP-ribose) polymerase (PARP), signal transducers and activators of transcription 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), B cell lymphoma-2 (BCL-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS 1), or GTPase Kras (KRAS).

14. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein PBM comprises the structure of formula selected from:Formula (PBM-5)R13Formula (PBM-6)                    Formula (PBM-7)Formula (PBM-9)           Formula (PBM-10)Formula (PBM-11)             Formula (PBM-12)Formula (PBM-13)                  Formula (PBM-14)Formula (PBM-15)Formula (PBM-16)Formula (PBM-17)Formula (PBM-18)Formula (PBM-19)R54R56 Formula (PBM-20)                Formula (PBM-21)              Formula (PBM-22)Formula (PBM-23)R73Formula (PBM-28)Formula (PBM-29)Formula (PBM-30)Formula (PBM-31)Formula (PBM-36)Formula (PBM-37)Formula (PBM-38)Formula (PBM-40)Formula (PBM-43)Formula (PBM-45)             Formula (PBM-46)                        Formula (PBM-47)Formula (PBM-48)Formula (PBM-49)Formula (PBM-50)Formula (PBM-52)Formula (PBM-51)wherein(R^pi indicates that the benzene ring in Formula (PBM-1) is substituted with pl R1, with each R1 being the same or different and each independently representing halogen, hydroxy, NH2, NO2, cyano, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;(R2)P2 indicates that the quinazoline ring in Formula (PBM-1) is substituted with p2 R2, with each R2 being the same or different and each independently representing halogen, NO2, cyano, halogenated C1-6 alkyl, Ci-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, halogenated C1-10 alkoxy, -O-optionally substituted heterocyclyl, or -NHC(O)R3, wherein R3 is Ci-10 alkyl, deuterated Ci-10 alkyl, or C2-100                           __alkenyl, e.g., R represents methyl, methoxy, h or          , such as          ;pl represents an integer of 1, 2, 3, 4 or 5;p2 represents an integer of 1, 2, or 3;(R4)P3 indicates that the benzene ring in Formula (PBM-2) is substituted with p3 R4, with each R4 being the same or different and each independently representing halogen, NO2, cyano, halogenated Ci-6 alkyl, Ci-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, or -NHC(O)R15a, where R15a is C1-10 alkyl, 04deuterated C1-10 alkyl, or C2-10 alkenyl, e.g., R represents methyl, methoxy, NO2, or h ;p3 represents an integer of 1, 2, 3 or 4;(R5)P4 indicates that the IH-indole ring in Formula (PBM-2) is substituted with p4 R5, with each R5 being the same or different and each independently representing C1-10 alkyl or deuterated C1-10 alkyl, and p4 represents an integer of 0, 1, 2 or 3;R6 represents hydrogen, C1-10 alkyl, or deuterated C1-10 alkyl;(R7)P5 indicates that the benzene ring in Formula (PBM-3) is substituted with p5 R7, with each R7 being the same or different and each independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, or cyano;p5 represents an integer of 0, 1, 2, 3, 4 or 5;R8 represents substituted or unsubstituted C3-15 cycloalkyl, e.g., cyclopentyl;(R9)P6 indicates that the benzene ring in Formula (PBM-4) is substituted with p6 R9, with each R9 being the same or different and each independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, C1-6 alkoxy, halogenated C1-6 alkoxy, or cyano;p6 represents an integer of 2, 3, 4 or 5;R10 represents Ce-io aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the Ce io aryl and heteroaryl are each optionally substituted with one or more Rbl, with each Rbl being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;(Rn)P7 indicates that the benzene ring and the pyridine ring in Formula (PBM-5) are each optionally substituted with p7 R11, with each p7 being the same or different and each independently representing an integer of 0, 1, 2 or 3, and each R11 in Formula (PBM-5) is the same or different and each independently represents halogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl;R12 represents hydrogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl;R13 in Formula (PBM-6) represents hydrogen, Ci-io alkyl (e.g.,^ ), deuterated Ci-io alkyl or halogenated Ci-io alkyl;o                      (Rb2)p8R14 represents nsT* or \— / . wherein (Rb2)P8 indicates that the piperidine ring is optionally substituted with p8 Rb2, with each Rb2 being the same or different and each independently representing deuterium, halogen, hydroxy, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, NO2, NH2, or cyano, and p8 represents an integer of 1, 2, 3, 4 or 5;ring A in Formula (PBM-7) represents Ce io aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring A is optionally substituted with one or more Rb3, with each Rb3 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C2-6 alkenyl, or C2-6 alkynyl;ring B in Formula (PBM-7) represents C3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring B is optionally substituted with one or more Rb4, with each Rb4 being the same or different and each independently representing deuterium, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;ring C in Formula (PBM-7) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring C is optionally substituted with one or more Rb5, with each Rb5 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;R15 in Formula (PBM-8) represents 4- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heterocyclyl is optionally substituted with one or more Rb6, with each Rb6 being the same or different and each independently representing halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;(R16)P9 indicates that the benzene ring in Formula (PBM-8) is substituted with p9 R16, with each R16 being the same or different and each independently representing halogen, Ci-6 alkyl, halogenated Ci-6 alkyl, or deuterated Ci-6 alkyl, and p9 represents an integer of 1, 2, 3 or 4;Xi in Formula (PBM-9) represents N or CRb7, wherein Rb7 is hydrogen or amino, and X2 represents N or CR17, wherein R17 is hydrogen or represents a bond, and X3 represents CH or N;R18 and R19 each independently represent hydrogen or a bond;(R2O)pio indicates that the benzene ring in Formula (PBM-9) is substituted with plO R20, with each R20 being the same or different and each independently representing -O-aryl, -O-heteroaryl, -C1-3 alkylene-NHC(O)-heteroaryl, -C1-3 alkylene-C(O)NH-heteroaryl or halogen, wherein the aryl and heteroaryl are each independently optionally substituted with one or more Rb8, with each Rb8 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, Ci-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;plO represents an integer of 1, 2, 3 or 4;R21 represents a bond, deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated Ci-6 alkyl, or Ci-6 alkoxy;R22 represents hydrogen, halogen, cyano, or amino;wherein R17, R18, R19, and R21 are not simultaneously hydrogen, and R17, R18, R19, and R21 do not simultaneously represent a bond, and only one of R17, R18, R19, and R21 represents a bond, whereinwhen R18 represents a bond, the carbon atom on the ring connected to R18 is directly connected to Rf, X2 represents CH or N, and R19 is hydrogen, and R21 is not a bond;when X2 represents CR17, where R17 represents a bond, the carbon atom on the ring connected to R17 is directly connected to Rf, and R18 and R19 are hydrogen, and R21 is not a bond;when R19 represents a bond, the nitrogen atom on the ring connected to R19 is directly connected to Rf, X2 represents N or CH, and R18 is hydrogen, and R21 is not a bond; andwhen R21 represents a bond, the carbon atom on the ring connected to R21 is directly connected to Rf, and X2 represents N or CH, and R18 and R19 are hydrogen;(R23)pii indicates that the cyclopentene ring in Formula (PBM-10) is substituted with pl 1 R23, with each R23 being the same or different and each independently representing halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6alkyl, and pl 1 represents an integer of 1, 2, 3, or 4;(R24)pi2 indicates that the pyridine ring in Formula (PBM-10) is substituted with pl2 R24, with each R24 being the same or different and each independently representing halogen, -C1-3 alkylene -OH, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p 12 represents an integer of 1, 2, or 3;R25 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;X’X4 in Formula (PBM-11) represents CR26 or a fragment R **, wherein symbol # indicates the point of attachment to N atom adjacent to X4, symbol ## indicates the point of attachment to X5, and R26 represents deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, -C(O)-Ci-6 alkyl, -C(O)-deuterated C1-6 alkyl, or -C(O)NRb9Rb10, where Rb9 and Rbl° are the same or different and each independently represent hydrogen, C1-6 alkyl or deuterated C1-6 alkyl;X5 in Formula (PBM-11) represents N or CR27, where R27 represents hydrogen, deuterium, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;Xe and X7 each independently represent CH or N;R28 represents a bond or optionally substituted heteroarylene (e.g., halogenated heteroarylene);R29 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-7 cycloalkyl;R30 and R31 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;R32 in Formula (PBM-12) represents hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;R33 represents hydrogen, cyano, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;(R34)pi3 indicates that the benzene ring in Formula (PBM-13) is substituted with p 13 R34, with each R34 being the same or different and independently representing halogen, hydroxy, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;p 13 represents an integer of 1, 2, 3, 4 or 5;R35 represents NRbllRb12, where Rbl1 and Rbl2 are the same or different and independently represent hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;(R36)pi4 indicates that the benzene ring in Formula (PBM-14) is optionally substituted with pl4 R36, with each R36 in Formula (PBM-14) being the same or different and each independently representing halogen, amino, cyano, C1-6alkyl, halogenated C1-6 alkyl, or deuterated C1-6alkyl, and pl4 represents an integer of 1, 2 or 3;R37 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;Xg, X9, X10, Xu and X12 in Formula (PBM-15) are the same or different and each independently represent N or CH;R38 represents a bond or optionally substituted methylene (e.g., halogenated methylene);R39 represents -C(O)NHRb13, -NHC(O)-Rb13, -S(O)2NHRb13, -N(Rbl4)S(O)2Rb13, -S(O)2Rb13 or -P(O)(Rbl3)2, wherein each Rbl3 is the same or different and each independently represents C1-6 alkyl or deuterated C1-6 alkyl, and Rbl4 represents hydrogen or C1-6 alkyl;(R40)pi5 indicates that the 6-membered ring containing X9 and X10 in Formula (PBM-15) is optionally substituted with pl5 R40, with each R40 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;pl5 represents an integer of 0, 1, 2, 3 or 4;R41 represents halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;(R42)pi6 indicates that the benzene ring in Formula (PBM-16) is optionally substituted with pl6 R42, with each R42 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;each pl6 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4;(R43)pi7 indicates that the benzene ring in Formula (PBM-17) is substituted with pl7 R43, with each R43 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and pl7 represents an integer of 0, 1, 2, 3 or 4;(R44)pi8 indicates that the benzene ring in Formula (PBM-18) is optionally substituted with pl8 R44, with each R44 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;pl8 represents an integer of 0, 1, 2, 3 or 4;(R45)pi9 indicates that the 4-oxo-3,4-dihydroquinazoline ring in Formula (PBM-18) is substituted with pl9 R45, with each R45 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;pl9 represents an integer of 1, 2, 3 or 4;(R46)P2o indicates that the benzene ring in Formula (PBM-19) is substituted with p20 R46, with each R46 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p20 represents an integer of 1, 2, 3, 4 or 5;R47 represents halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;(R48)P2i indicates that the quinoline ring in Formula (PBM-20) is substituted with p21 R48, with each R48 being the same or different and each independently representing halogen, cyano, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p21 represents an integer of 1, 2, 3 or 4;(R49)P22 indicates that the benzene ring in Formula (PBM-20) is substituted with p22 R49, with each R49 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p22 represents an integer of 2, 3 or 4;R50 in Formula (PBM-21) represents -NHC(O)- or -C(O)NH-;R51 represents -NH- or ethynylene;(R52)p23 indicates that the benzene rings in Formula (PBM-21) are each optionally substituted with p23 R52, with each R52 being the same or different and each independently representing halogen, Ci-6 alkoxy, Ci-6 alkyl, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;each p23 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4;ring D in Formula (PBM-21) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R53)P24 indicates that the ring D is optionally substituted with p24 R53, with each R53 being the same or different and each independently representing optionally substituted 5- to 15-membered heteroaryl, deuterium, halogen, hydroxy, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy;p24 represents an integer of 0, 1, 2, or 3;only one of R54, R55, R56, and R57 in Formula (PBM-22) represents a bond, and the remaining are the same or different and each independently represent hydrogen, halogen, or hydroxy, wherein when one of R54, R55, R56 and R57 represents a bond, the benzene ring or methylene in Formula (PBM-22) connected to the bond is directly connected to Rf;symbol “    ” connected to double bond in Formula (PBM-22) represents a bond in stereoconfiguration (cis or trans configuration, or E- or Z-configuration);X13 in Formula (PBM-23) represents -O- or -CH2-;(R58)p25 indicates that 1,2,3,4-tetrahydronaphthalene ring in Formula (PBM-23) is substituted with p25 R58, with each R58 being the same or different and each independently representing hydrogen, hydroxy, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;p25 represents an integer of 1, 2, 3 or 4;one of R59 and R60 represents a bond, and another represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, wherein when one of R59 and R60 represents a bond, the carbon atom on the ring in Formula (PBM-23) connected to the bond is directly connected to Rf;ring E in Formula (PBM-24) represents 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur;R62 represents optionally substituted 5- to 15-membered heteroaryl, optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;R61 represents halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl;R63 in Formula (PBM-25) represents optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;R64 represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heteroaryl isoptionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, cyano, amino, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, or any combination thereof;(R65)P26 indicates that the isoquinoline ring in Formula (PBM-26) is substituted with p26 R65, with each R65 being the same or different and each independently representing hydrogen, hydroxy, halogen, Ci-6 alkyl, Ci-6 alkoxy, -C(0)NH2, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;p26 represents an integer of 1, 2, 3 or 4;groups R66 are the same or different and each independently represent hydrogen, hydroxy, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;X14 in Formula (PBM-27) represents N or CRb23, where Rb23 represents hydrogen or halogen, and X15 represents N or CH;R67 represents a bond, -C(O)NH- or -NHC(O)-;R68 represents halogen, Ci-6 alkyl, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;R69 represents hydrogen, Ci-6 alkyl, deuterated Ci-6 alkyl, halogenated Ci-6 alkyl, or -C1-3 alkylene-C3-6 cycloalkyl;R70 represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; orR69 and R70 together with the corresponding nitrogen and carbon atoms to which they are connected form an optionally substituted 5- to 7-membered nitrogen-containing heterocycle;R71 represents hydrogen or a bond, R72 represents hydrogen or a bond, wherein R71 and R72 are not simultaneously hydrogen, and only one of R71 and R72 represents a bond, and another represents hydrogen, wherein when R71 represents a bond, the carbon atom on the ring connected to R71 is directly connected to Rf, and when R72 represents a bond, the carbon atom on the ring connected to R72 is directly connected to Rf;R74 in Formula (PBM-28) represents a bond, C1-3 alkylene or halogenated C1-3 alkylene;R73 represents optionally substituted Cs ecycloalkyl, halogenated C3-6 cycloalkyl, or optionally substituted C1-6 alkyl;R75 in Formula (PBM-29) represents C1-3 alkylene or halogenated C1-3 alkylene;R76 represents C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-6 cycloalkyl;R77 in Formula (PBM-30) represents C1-3 alkylene or halogenated C1-3 alkylene;R78 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;R79 and R80 are the same or different and each independently represent hydrogen, optionally substituted C1-10 alkyl or optionally substituted C3-6 cycloalkyl;R81 represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;Xi6 in Formula (PBM-31) represents -S- or a fragment , wherein when Xi6 represents -S-, heteroaryl containing Xi6 and nitrogen atom in Formula (PBM-31) is thiazolyl, and when Xi6represents the fragment , the heteroaryl containing Xi6 and nitrogen atom in Formula (PBM-31) is pyridyl;X17 represents N or CH;R82 represents hydrogen or optionally substituted Ci-io alkyl;R83 represents hydrogen, -C1-3 alkylene-optionally substituted 4- to 10-membered heterocyclyl, or optionally substituted 4- to 10-membered heterocyclyl;R84 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;R85 and R86 in Formula (PBM-32) are the same or different and each independently represent hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;R87 represents -S(O)2NH2 or -C(0)NH2;R88 in Formula (PBM-33) represents hydrogen, hydroxy, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;R89 represents C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; orR88 and R89 together with the corresponding carbon and nitrogen atoms to which they are connected form an optionally substituted 4- to 6-membered heteroaromatic ring or optionally substituted 4- to 6-membered heterocycle;R90 represents optionally substituted C3-6 cycloalkyl, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl or optionally substituted 4- to 10-membered heterocyclyl;(R91)p27 incicates that pyridin-2(lH)-one ring in Formula (PBM-33) is substituted with p27 R91, with each R91 being the same or different and each independently representing hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p27 represents an integer of 1, 2 or 3;ring F in Formula (PBM-33) represents arylene or 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; (R92)P28 incicates that the ring F is optionally substituted with p28 R92, with each R92 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated Ci-6 alkoxy;p28 represents an integer of 0, 1, 2, 3 or 4;(R93)p29 indicates that the benzene ring in Formula (PBM-34) is substituted with p29 R93, with each R93 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;p29 represents an integer of 1, 2, 3, 4 or 5;R94 represents hydrogen, hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;R95 represents NRbl5Rb16, where Rbl5 and Rbl6 are the same or different and each independently represent hydrogen, Ci-6 alkyl, deuterated Ci-6 alkyl, halogenated Ci-6 alkyl, optionally substituted C3-6 cycloalkyl, or optionally substituted 4- to 8-membered heterocyclyl;Xis, X19 and X20 in Formula (PBM-35) are the same or different and each independently represent CH or N, wherein Xis, X19 and X20 are not simultaneously N, and the 6-membered ring containing Xis, X19, X20 and nitrogen atom is optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, cyano, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or any combination thereof;X21 and X22 in Formula (PBM-35) are the same or different and each independently represent C or N, wherein X21 and X22 are not simultaneously N;(R96)p30 indicates that the benzene ring in Formula (PBM-35) is substituted with p30 R96, with each R96 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p30 represents an integer of 1, 2, 3, 4 or 5;(R97)P3i indicates that the pyrrolidine ring in Formula (PBM-35) is optionally substituted with p31 R97, with each R97 being the same or different and each independently representing hydrogen, hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;p31 represents an integer of 0, 1, 2, 3, 4, 5 or 6;R98, R99, and R100 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl;X23 in Formula (PBM-36) represents CH or N;R101 represents a bond or -S-;R102 represents a bond or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl;R103 represents a bond, halogen, amino, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl;wherein R102 and R103 are not simultaneously a bond, and only one of R102 and R103 is a bond, wherein when R102 represents a bond, the carbon atom on the ring connected to R102 is directly connected to Rf, and when R103 represents a bond, the carbon atom on the ring connected to R103 is directly connected to Rf;(R104)P32 indicates that the 6-membered ring in Formula (PBM-36) is optionally substituted with p32 R104, with each R104 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;p32 represents an integer of 0, 1, 2, 3 or 4;(R1o^)P33 indicates that the benzene ring in Formula (PBM-37) is optionally substituted with p33 R105, with each R105 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl, or halogenated Ci-6 alkyl;p33 represents an integer of 1, 2, 3 or 4;(R106)P34 indicates that the phthalazinone ring in Formula (PBM-37) is optionally substituted with p34 R106, with each R106 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p34 represents an integer of 0, 1, 2, 3 or 4;(R107)P35 indicates that the 2H-indazole ring in Formula (PBM-38) is optionally substituted with p35 R107, with each R107 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p35 represents an integer of 0, 1, 2 or 3;(R10^)P36 indicates that the benzene ring in Formula (PBM-38) is optionally substituted with p36 R108, with each R108 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p36 represents an integer of 0, 1, 2 or 3;(R109)P37 indicates that the 2H-indazole ring in Formula (PBM-39) is optionally substituted with p37 R109, with each R109 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p37 represents an integer of 0, 1, 2 or 3;(R110)P38 indicates that the benzene ring in Formula (PBM-39) is optionally substituted with p38 R110, with each R110 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p38 represents an integer of 0, 1, 2 or 3;(R111)P39 indicates that the benzene ring in Formula (PBM-40) is optionally substituted with p39 R111, with each R111 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p39 represents an integer of 0, 1, 2, 3 or 4;R112, R113, and R114 are the same or different and each independently represent hydrogen, halogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;R115 in Formula (PBM-41) represents hydrogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;R116, R117, and R118 are the same or different and each independently represent hydrogen, halogen, Ci-6 alkyl, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;(R119)P4o indicates that the benzene ring in Formula (PBM-41) is optionally substituted with p40 R119, with each R119 being the same or different and each independently representing hydroxy, amino, cyano, halogen, Ci-6 alkyl, Ci-6 alkoxy, deuterated Ci-6 alkyl or halogenated Ci-6 alkyl;p40 represents an integer of 0, 1, 2, 3 or 4;R120 and R121 in Formula (PBM-42) are the same or different and each independently represent hydrogen, halogen, C1-3 alkyl or halogenated C1-3 alkyl;R122 represents a bond, hydrogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl;R123 represents the structure of the following formula:wherein R124 represents a bond or hydrogen; (R125)p4i indicates that the benzene ring is optionally substituted with p41 R125, with each R125 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p41 represents an integer of 0, 1, 2, 3 or 4; orR123 represents the structure of the following formula:^(R126)p42^ / (R126)p42wherein (R126)P42 indicates that the benzene ring is optionally substituted with p42 R126, with each R126 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p42 represents an integer of 0, 1, 2, 3, 4 or 5;wherein R122 and R124 are not simultaneously a bond, and only one of R122 and R124 represents a bond, wherein when R122 represents a bond, the nitrogen atom on the ring connected to R122 is directly connected to Rf, and when R124 represents a bond, the carbon atom on the ring connected to R124 is directly connected to Rf;(R127)P43 indicates that the benzene ring in Formula (PBM-43) is optionally substituted with p43 R127, with each R127 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p43 represents an integer of 0, 1, 2, 3 or 4;R131 in Formula (PBM-45) represents C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl or hydrogen;R132 represents Ci-6 alkyl, deuterated Ci-6 alkyl, halogenated Ci-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted 4- to 8-membered nitrogen-containing heterocyclyl or NRbl7Rb18, where Rbl7 and Rbl8 are the same or different and each independently represent hydrogen, C1-6 alkyl, deuterated C1-6 alkyl or optionally substituted 4- to 8-membered heterocyclyl;(R133)P46 indicates that the benzene ring in Formula (PBM-45) is optionally substituted with p46 R133, with each R133 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p46 represents an integer of 0, 1, 2, 3 or 4;(R134)P47 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p47 R134, with each R134 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p47 represents an integer of 0, 1, 2, 3 or 4;(R135)P48 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p48 R135, with each R135 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl;p48 represents an integer of 0, 1, 2, 3 or 4;ring H in Formula (PBM-48) represents Ce-io arylene or C5-10heteroarylene, and (R137)P49 indicates that the ring H is optionally substituted with p49 R137, with each R137 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;p49 represents an integer of 0, 1, 2, 3 or 4;R136 represents optionally substituted 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, which is optionally substituted with a substituent selected from the group consisting of hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl;X24, X25, and X26 in Formula (PBM-49) each independently represents CH or N;R138 represents -C(O)NHRb19, -NHC(O)-Rb19, -S(O)2NHRb19, -NHS(O)2Rb19, -S(O)2Rb19 or -P(O)(Rbl9)2, wherein each Rbl9 is the same or different and each independently represents C1-6 alkyl or deuterated C1-6 alkyl;R139 and R140 each independently represent halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;(R141)P5o indicates that the benzene ring is optionally substituted with p50 R141, with each R141 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;p50 represents an integer of 0, 1, 2, 3 or 4; and(R143)P5i in Formula (PBM-50) indicates that the benzene ring is optionally substituted with p51 R143, with each R143 being independently halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy;p51 represents an integer of 0, 1, 2, 3, 4 or 5;R142 represents H, Ci-6 alkyl or halogenated Ci-6 alkyl;(R144)P52 indicates that the quinazoline ring in Formula (PBM-50) is optionally substituted with p52 R144, with each R144 being independently halogen, hydroxy, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy, and p52 represents an integer of 1, 2, or 3;Rq in Formula (PBM-51) represents a bond, or Re represents -NH-Rg-C(O)-***, wherein symbol *** indicates the point of attachment to Rn, and Rn represents optionally substituted C3-8 cycloalkyl;(R145)P53 indicates that the lH-pyrrolo[2,3-b]pyridine ring in Formula (PBM-51) is optionally substituted with p53 R145, with each R145 being independently cyano, halogen, hydroxy, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p53 represents an integer of 0, 1, 2, 3, 4 or 5;(R146)P54 indicates that the pyridine ring in Formula (PBM-51) is optionally substituted with p54 R146, with each R146 being independently cyano, halogen, hydroxy, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy or NRb25Rb26, wherein Rb25 and Rb26 are the same or different and each independently represent hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl or optionally substituted 4- to 8membered heterocyclyl, and p54 represents an integer of 0, 1, 2 or 3; and(R147)P55 in Formula (PBM-52) indicates that the benzene ring is optionally substituted with p55 R147, with each R147 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy or halogenated C1-6 alkoxy, and p55 represents an integer of 0, 1, 2, 3, 4 or 5;R148 represents NHC(O) or C(O)NH;(R149)P56 indicates that the IH-pyrazole ring in Formula (PBM-52) is optionally substituted with p56 R149, with each R149 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy or halogenated C1-6 alkoxy, and p56 represents an integer of 0, 1 or 2; andX27 in Formula (PBM-53) represents N or CH;R150 represents a bond or optionally substituted methylene (e.g., halogenated methylene);ring I represents Ce-io arylene or 5- to 15-membered heteroarylene, and (R151)P57 indicates that the ring I is optionally substituted with p57 R151, with each R151 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, oxo, C1-6 alkyl,halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy, and p57 represents an integer of 0, 1, 2, 3 or 4;(R1^2)p58 indicates that the 6-membered ring containing X27 in Formula (PBM-53) is optionally substituted with p58 R152, with each R152 independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p58 represents an integer of 0, 1 or 2;(R153)P59 indicates that the benzene ring in Formula (PBM-53) is optionally substituted with p59 R153, with each R153 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and pl5 represents an integer of 0, 1, 2, 3 or 4;X28, X29 and X30 in Formula (PBM-54) independently represent N or CH;(R154)P6o indicates that the naphthyl in Formula (PBM-54) is optionally substituted with p60 R154, with each R154 independently representing halogen, hydroxy, amino, mercapto, nitro, cyano, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl or halogenated C1-6 alkyl, and p60 represents an integer of 0, 1,2, 3, 4, 5, 6 or 7;R155 represents optionally substituted C3-11 cycloalkyl or optionally substituted 4- to 15-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur;R156 represents hydrogen, halogen, hydroxy, cyano, amino, mercapto, nitro, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl or halogenated C1-6 alkyl;R157 in Formula (PBM-55) represents Ce io aryl, or heteroaryl containing one or two 5- to 7membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the Ce io aryl and heteroaryl are each optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;Ri58 represents 5- to 15-membered heteroaryl containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the 5- to 15-membered heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy;(R159)P6i indicates that the isoindolinone ring in Formula (PBM-55) is substituted with p61 R159, with each R159 being the same or different and each independently representing halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p61 represents an integer of 0, 1, 2 or 3;X31 in Formula (PBM-56) represents N or CH;(R160)p62 indicates that the aromatic ring containing X31 in Formula (PBM-56) is substituted with p62 R160, with each R160 being the same or different and each independently representing halogen,hydroxy, mercapto, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy, and p62 represents an integer of 0, 1, 2, 3 or 4; andring J represents 5- to 15-membered heteroarylene, and (R161)P63 indicates that the ring J is optionally substituted withp63 R161, with each R161 being the same or different and each independently representing halogen, hydroxy, mercapto, cyano, amino, nitro, Ci-6 alkyl, halogenated Ci-6 alkyl, deuterated Ci-6 alkyl, hydroxy substituted Ci-6 alkyl, Ci-6 alkoxy, or halogenated Ci-6 alkoxy, and p63represents an integer of 0, 1, 2 or 3.

15. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein PBM comprises thestructure of formula selected from:Formula (PBM-9-1) Formula (PBM-9-2) Formula (PBM-9-3) Formula (PBM-9-4)Formula (PBM-9-5) Formula (PBM-10-1)          Formula (PBM-10-2)Formula (PBM-11-1) Formula (PBM-11-2) Formula (PBM-11-3)       Formula (PBM-12-1)       Formula (PBM-13-1) Formula (PBM-14-1)Formula (PBM-15-11) Formula (PBM-16-1) Formula (PBM-17-1) Formula (PBM-18-1) Formula (PBM-19-1)    Formula (PBM-20-1)Formula (PBM-23-2) Formula (PBM-23-3) Formula (PBM-23-4) Formula (PBM-23-5) Formula (PBM-23-6) Formula (PBM-23-7) Formula (PBM-23-8)Formula (PBM-24-1)Formula (PBM-24-2)Formula (PBM-24-3)         Formula (PBM-25-1)          Formula (PBM-25-2)Formula (PBM-25-3) Formula (PBM-26-1) Formula (PBM-27-1) Formula (PBM-27-3) Formula (PBM-28-1) Formula (PBM-28-2)Formula (PBM-27-2)Formula (PBM-33-1)Formula (PBM-33-2)Formula (PBM-33-3)Formula (PBM-34-1)Formula (PBM-35-1)Formula (PBM-35-2)Formula (PBM-35-3)Formula (PBM-35-4)Formula (PBM-35-5)Formula (PBM-35-6)Formula (PBM-40-1)Formula (PBM-45-1)Formula (PBM-45-4) Formula (PBM-46-1)Formula (PBM-43-1)Formula (PBM-47-1)Formula (PBM-48-1)         Formula (PBM-48-2)Formula (PBM-49-2)Formula (PBM-49-3)Formula (PBM-49-4)Formula (PBM-49-5)Formula (PBM-50-1)Formula (PBM-50-2)Formula (PBM-51-3)Formula (PBM-52-1)Formula (PBM-53-1)Formula (PBM-53-3)FOH Formula (PBM-54-1)Formula (PBM-55-1)Formula (PBM-53-4)Formula (PBM-56-3)Formula (PBM-56-4) Formula (PBM-56-5)Formula (PBM-56-6)16. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, whereinRf represents a bond, -O-, -NHC(O)-*, -C(0)NH-*, or -NH-, orRf represents the structure of the following formula:-N(Rg)-, -NHC(O)-Ci-6 alkylene-W5-*, -NHC(O)-C2-6 alkenylene-W5-*, -C(O)NH-Ci-6 alkylene-W5-*, -C(O)NH-C2-6 alkenylene-W5-*, -NHC(0)-W5-*, -C(0)NH-W5-*, -O-Ci-6 alkylene-W5-*, -0-C2-6 alkenylene-W5-*, -0-W5-*, -O-Ci-6 alkylene-N(Ri)-*, -O-C2-6 alkenylene-N(Ri)-*, -N(Rg)-Ci-6 alkylene-N(Ri)-*, -N(Rg)-C2.6 alkenylene-N(R,)-*, -W5-, -W5-N(Rg)-*, -N(Rg)-W5-*, -N(Rg)-W5-N(R0-*, -Ci-6 alkylene-W5-*, -C2-6 alkenylene-W5-*, -Ci-6 alkylene -C(0)-W5-*, -C2-6 alkenylene-C(0)-W5-*, -C(0)-W5-*, -Ci-6 alkylene-C(0)NH-Ci-6 alkylene-W5-*, -Ci-6 alkylene-C(O)NH-C2-6 alkenylene-W5-*, -C2-6 alkenylene-C(0)NH-Ci-6 alkylene-W5-*, -C2-6 alkenylene-C(O)NH-C2-6 alkenylene-W5-*, -Ci-6 alkylene-NHC(0)-Ci-6 alkylene-W5-*, -Ci-6 alkylene-NHC(O)-C2-6 alkenylene-W5-*, -C2-6 alkenylene-NHC(0)-Ci-6 alkylene-W5-*, -C2-6 alkenylene-NHC(O)-C2-6 alkenylene-W5-*, -Ci-6 alkylene-C(O)NH-*, -C2-6 alkenylene-C(O)NH-*, -Ci-6 alkylene-NHC(O)-*, -C2-6 alkenylene-NHC(O)-*, -Ci-6 alkylene-, -C2-6 alkenylene-, -Ci-6 alkylene-N(Ri)-*, -C2-6 alkenylene-N(Ri)-*,                 *,wherein Rg and Ri each independently represent hydrogen or Ci-6 alkyl, and the Ci-6 alkylene and C2-6 alkenylene are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, Ci-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof;wherein W5 represents the structure of the following formula:wherein each rings W6 is the same or different and each independently represents nitrogencontaining heterocyclylene, tl represents an integer of 1 or 2 , and (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, wherein Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and the C1-6 alkylene and C2-6 alkenylene is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof, and m2 represents an integer of 0-20;each ring W7 is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, and (Ra3)m3 indicates that each ring W7 is independently optionally substituted with m3 Ra3 substituents, with each Ra3 being independently deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; andsymbol * indicates the point of attachment to LIN.

17. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein Rf represents -W7-Rh-W5-*, wherein Rh represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, W5 and W7 are as defined in claim 12 or 16.

18. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12 or 16-17, wherein W5 represents the structure of the following formula:-Hr w7l4( WNrh *4i(Ra3)m3 (Ra2)m2wherein each ring W6 is the same or different and each independently represents 4- to 20-membered nitrogen-containing heterocyclylene, e.g.,piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene,azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo [3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, orf-N^NH iN^NH f     -^NH -^NH HN^N^ ^NH _^Htl represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-Rlla-, wherein Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and the C1-6 alkylene and C2-6 alkenylene are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof, and m2 represents an integer of 0-20;each ring W7 is the same or different and each independently represents 4- to 15-membered nitrogencontaining heterocyclylene, 6- to 10-membered arylene, or 5- to 10-membered heteroarylene, e.g.,piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene,azabicyclo [3.1.1 ]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,l,3]oxadiazolylene, benzo[2,l,3]thiadiazolylene, benzo[l,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[l,5-a]pyridylene, pyrazolo[l,5-a]pyrimidinylene, imidazo[l,2-a]pyridylene, lH-pyrrolo[3,2-b]pyridylene, lH-pyrrolo[2,3-b]pyridylene, pyrrolo[2,l-b]thiazolylene, and imidazo[2,l-b]thiazolylene, ort2 represents an integer of 0 or 1, (Ra3)m3 indicates that each ring W7 is optionally substituted with m3 Ra3 substituents, with each Ra3 being independently deuterium, optionally deuterated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-,hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; andsymbol * indicates the point of attachment to LIN.

19. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 16 or 17, wherein W5 represents thefollowing groups:-KIX* HEX* KZX* HEX* XEX* i-XX* -^ZX* AnCX X2XX)nXEX* 'KX\IX* ^n(XnClX* ^nXXlX* X)nXlx*.               OHor +\Z~bwherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, R12a-Rlla-, or any combination thereof, wherein Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and symbol * indicates the point of attachment to LIN.

20. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12 or 16-17, wherein Rf represents the following groups:a bond, -O-, -NHC(O)-*, -C(O)NH-*, -NH-, -N(CH3)-, -N(CH3)-(CH2)2-N(CH3)-*, -N(CH3)-(CH2)3-N(CH3)-*, -NH-(CH2)2-N(CH3)-*, -N(CH3)-(CH2)3-NH-*, -CH2-NHC(O)-*, -CH2-C(O)NH-*,-CH2-NH-*, -O-(CH2)2-N(CH3)-*, -O-(CH2)2-NH-*, or -CH2-N(CH3)-*, or^XX’4 N Oz 1 Xna      Xnz. -i-N^ - -i-dX* O* F -|-<Qn^-.            . ZNX__-^- XIX* ^XCN^* XIX * ZN^ ^-. -^N^ nZ*         . F ~\          " ~^~\       3^* i-N^dX* i\XCX* XZXXi-* -XZX3X* XXXX • ^\X~nClH4 ^XXXX* XZXCX* N=N / --\        N=\   / --\ \__ / N1“* ~^xxn?x *1        ’ XOXZX* xXXOn^4 z=\              N=N / s-\ ^vX\J_X4 ^VXvlX' -kQXZX* xXKZX* ■KZXdX* xX~NdX* ^AX~d / N_^4 -^IXCX * zn(XnXX * '^n0—yy~^ * Zn^Xn^X* iXN~XX* v    ^a,   .^a '-'^N'^ fN  N >   N     N A  X      A  fN  N A Uz " U. 1   Uz    <A 1 Uz. ___N^      L___N^     k / N,^        LvN **     LvN” * /     Cl ^N\__ / N^* N\__ / N’^* \ F\ nQ3n7* -i-n^Qn-i-. i-n^M” zn33n7* i’N^)“b         -h^n-i- <z> i-Cn-i - o o s-"Z> w / N |-. |-N Vf-. -|-6 N |-. -|-N   2   < N j-. |-( N j-. -|-(    N-|-. 7—3 7* ^N\                ^”N\ / N—3n ^~ * n /               <3n'^*                ~dZ / N— i’NdXNC0 * ^ddCLd* ‘^CD-CU^-4 ^3dN-d / N~^* zn(3^nC2^^ ^^3n~3Dn^* ^X3n^CZ / ^ * ~^^nCZ^4 N=\   / --\ 4    4 / =\   /  \ 4    4 / N=\        S   4 / N=\        > ■k^>-nCDn^* -^00^-     CN^‘* -^^O>-nCn^4 _^D^nCn^4 KJ"Cn^4 kZ?“3ZIM4 -hQ^C^-4 mLhClX*                * ■         -^1^371^4 ~XXNCZX4 MLhKZX* ’K^zvv^"4 ’^V^vV^4 ^^avv^-4 _K_ / ~\XN^’4 -^aX’n^^4          ^3ZXzZX4 * 7n33-n\C>_^ * xZ / nXZX* ~k3XX * ‘^XdH4 7nCX33H4 i^O^ClX4 ■^X-dX * ’VO-dX* ’^Xn—OX 4wherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, R12a-Rlla-, or any combination thereof, wherein Rlla is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; andsymbol * indicates the point of attachment to LIN.

21. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein ULM represents thestructure of the following Formula (ULM-1), Formula (ULM-2), Formula (ULM-3), Formula(ULM-4), Formula (ULM-5), Formula (ULM-6), Formula (ULM-7), Formula (ULM-8), Formula(ULM-9), Formula (ULM-10), Formula (ULM-11), or Formula (ULM-12):Formula (ULM-1)Formula (ULM-3)Formula (ULM-5)Formula (ULM-2)Formula (ULM-7)         Formula (ULM-8)Formula (ULM-9)Formula (ULM-6)Formula (ULM-12) .Formula (ULM-10) Formula (ULM-11)whereinA represents CO, CH2 or CD2;Ri, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl;(Rb)n indicates that benzene ring is optionally substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6alkynyl, or C2-6 alkenyl; andN represents an integer of 0, 1, 2 or 3.

22. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein ULM represents the structure of the following Formula (ULM-13), Formula (ULM-14), Formula (ULM-15), Formula (ULM-16), Formula (ULM-17), Formula (ULM-18), Formula (ULM-19), Formula (ULM-20), Formula (ULM-21), Formula (ULM-22), Formula (ULM-23), or Formula (ULM-24):Formula (ULM-13)Formula (ULM-14)Formula (ULM-15)Formula (ULM-16)Formula (ULM-17) Formula (ULM-18)Formula (ULM-21) Formula (ULM-22)Formula (ULM-23) or Formula (ULM-24) .5wherein A, (Rb)n, and Rb are as defined in claim 19.

23. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein ULM represents thestructure of the following formula:1006o1008100924. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-22, wherein LIN represents the structure of the following formula:wherein Rs and Re are the same or different and each independently represent:hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl,wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or Ci-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; anda hydrogen atom of methyl and hydrogen atom of one or more CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof.

25. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-22, wherein R5 and Re are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, or iodine, or represent the structure of the following formula:-Ci-30 alkyl;-(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H;-(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-(Rc-(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))^^-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-(Rd-(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))^^-(C(Ra4)(Ra5))ni-(Rc-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H;-(C(Ra4)(Ra5))^^                             or-(C(Ra4)(Ra5))ni-(Rd-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H;wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Re), N(Re)C(O), or N(Re)C(0)N(Re), wherein each Re independently represents H or Ci-6 alkyl; and each Rd is selected from the group consisting of cycloalkylene (e.g., C3-2ocycloalkylene), arylene (e.g., C3-2oarylene), heterocyclylene (e.g., 4- to 20membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene ) or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof;a hydrogen atom of one or more CH2 of C1-30 alkyl is optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated Ci-6 alkyl-C(O)NH-; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

26. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein R5 and Re are the sameor different and each independently represent the structure of the following formula:-(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H;-(C(Ra4)(Ra5))ni-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(N(Re)-(C(Ra6)(Ra7))^<(Ra4)r)k-NRcHC>a6)(Ral^^-(C(Ra4)(Ra5))ni-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))nHC(O)N(Rc)-(Q-(C(Ra4)(Ra5))ni-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-(C(O)N(Re)-(C(Ral0)(Rall))n4)m6-H;<C(Ra4)rti<C(O)TO<(Ra4)(Ra5))nrC(O)N(Rc)<^-(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-H;-(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7)^^-(C(Ra4)(Ra5))ni-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O-(C(Ral0)(Rall))n4)m6-H;-(C(Ra4)(Ra5))ni-N(Re)C(O)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H;-(C(Ra4)(Ra5))ni-N(Re)C(O)N(Re)-(C(Ra6)(Ra7))n2-H;-(C(Ra4)(Ra5))ni-C(O)-(C(Ra6)(Ra7))n2-H;-(C(Ra4)(Ra5))ni-(arylene-(C(Ra6)(Ra7))n2)m4-H;<(Ra4)(Ra5))nHarylene<(Ra6X-(C(Ra4)(Ra5))ni-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-H;<(Ra4)(Ra5))nHhelerocyclylene<^-(C(Ra4)(Ra5))ni-(heteroarylene-(C^-(C(Ra4)(Ra5))ni-(heteroarylene-(C(Ra6)(Ra7))n2)m4-(heteroarylene-(C(Ra8)(Ra9))n3)m5-H;<(Ra4)(Ra5))nHcycloalky^                   or-(C(Ra4)(Ra5))ni-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-(cycloalkylene-(C(Ra8)(Ra9))n3)m5-H;wherein each Re independently represents H or Ci-6 alkyl;the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof;Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ral° and Ral1 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl,optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated Ci-6 alkyl-C(O)NH-; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

27. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein R5 and Re are the same or different and each independently represent the following groups:H, fluorine, chlorine, bromine, iodine, -CH3, -CH2-CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2)io-CH3, -(CH2)ii-CH3, -(CH2)i2-CH3, -(CH2)i3-CH3, -(CH2)i4-CH3, -(CH2)i5-CH3, -(CH2)i6-CH3, -(CH2)i7-CH3, -(CH2)i8-CH3, -(CH2)19-CH3, -(CH2)20-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)25-CH3, -(CH2)29-CH3;-CH2-O-CH3, -CH2-O-CH2-CH3, -CH2-O-(CH2)2-CH3, -(CH2)i-O-(CH2)3-CH3, -(CH2)i-O-(CH2)4-CH3, -(CH2)i-O-(CH2)5-CH3, -(CH2)i-O-(CH2)6-CH3, -(CH2)i-O-(CH2)7-CH3, -(CH2)i-O-(CH2)8-CH3, -(CH2)i-O-(CH2)9-CH3, -(CH2)i-0-(CH2)io-CH3, -(CH2)2-O-CH3, -(CH2)2-O-CH2-CH3, -(CH2)2-O-(CH2)2-CH3, -(CH2)2-O-(CH2)3-CH3, -(CH2)2-O-(CH2)4-CH3, -(CH2)2-O-(CH2)5-CH3, -(CH2)2-O-(CH2)6-CH3, -(CH2)2-O-(CH2)7-CH3, -(CH2)2-O-(CH2)8-CH3, -(CH2)2-O-(CH2)9-CH3, -(CH2)2-0-(CH2)io-CH3, -(CH2)2-O-(CH2)n-CH3, -(CH2)2-O-(CH2)12-CH3, -(CH2)3-O-CH3, -(CH2)3-O-CH2-CH3, -(CH2)3-O-(CH2)2-CH3, -(CH2)3-O-(CH2)3-CH3, -(CH2)3-O-(CH2)4-CH3, -(CH2)3-O-(CH2)5-CH3, -(CH2)3-O-(CH2)6-CH3, -(CH2)3-O-(CH2)7-CH3, -(CH2)4-O-CH3, -(CH2)4-O-CH2-CH3, -(CH2)4-O-(CH2)2-CH3, -(CH2)4-O-(CH2)3-CH3, -(CH2)4-O-(CH2)4-CH3, -(CH2)4-O-(CH2)5-CH3, -(CH2)4-O-(CH2)6-CH3, -(CH2)5-O-CH3, -(CH2)5-O-CH2-CH3, -(CH2)5-O-(CH2)2-CH3, -(CH2)5-O-(CH2)3-CH3, -(CH2)5-O-(CH2)4-CH3, -(CH2)5-O-(CH2)5-CH3, -(CH2)6-O-CH3, -(CH2)6-O-CH2-CH3, -(CH2)6-O-(CH2)2-CH3, -(CH2)6-O-(CH2)3-CH3, -(CH2)6-O-(CH2)4-CH3, -(CH2)7-O-CH3, -(CH2)7-O-CH2-CH3, -(CH2)7-O-(CH2)2-CH3, -(CH2)7-O-(CH2)3-CH3, -(CH2)8-O-CH3, -(CH2)8-O-CH2-CH3, -(CH2)8-O-(CH2)2-CH3, -CH(CH3)-O-CH3, -CH(CH3)-O-CH2-CH3, -CH(CH3)-O-(CH2)2-CH3, -CH(CH3)-O-(CH2)3-CH3, -CH(CH3)-O-(CH2)4-CH3, -CH(CH3)-O-(CH2)5-CH3, -CH(CH3)-O-(CH2)6-CH3, -CH(CH3)-O-(CH2)7-CH3, -CH(CH3)-O-(CH2)8-CH3, -CH(CH3)-O-(CH2)9-CH3, -CH(CH3)-0-(CH2)io-CH3, -ch2-(O(CH2)2)i-OCH2CH3, -CH2-(O(CH2)2)2-OCH2CH3, -CH2-(O(CH2)2)3-OCH2CH3, -CH2-(O(CH2)2)4-OCH2CH3, -CH2-(O(CH2)2)5-OCH2CH3, -CH2-(O(CH2)2)6-OCH2CH3, -CH2-(O(CH2)2)7-OCH2CH3, -CH2-(O(CH2)2)8-OCH2CH3, -CH2-(O(CH2)2)9-OCH2CH3, -CH2-(0(CH2)2)io-OCH2CH3, -ch2-(O(CH2)2)i-OCH3, -CH2-(O(CH2)2)2-OCH3, -CH2-(O(CH2)2)3-OCH3, -CH2-(O(CH2)2)4-OCH3, -ch2-(O(CH2)2)5-OCH3, -CH2-(O(CH2)2)6-OCH3, -CH2-(O(CH2)2)7-OCH3, -CH2-(O(CH2)2)8-OCH3, -ch2-(O(CH2)2)9-OCH3, -CH2-(0(CH2)2)io-OCH3, -(CH2)2-(O(CH2)2)i-OCH2CH3, -(CH2)2-(O(CH2)2)2-OCH2CH3, -(CH2)2-(O(CH2)2)3-OCH2CH3, -(CH2)2-(O(CH2)2)4-OCH2CH3, -(CH2)2-(O(CH2)2)5-OCH2CH3, -(CH2)2-(O(CH2)2)6-OCH2CH3, -(CH2)2-(O(CH2)2)7-OCH2CH3, -(CH2)2-(O(CH2)2)8-OCH2CH3, -(CH2)2-(O(CH2)2)9-OCH2CH3, -(CH2)2-(0(CH2)2)io-OCH2CH3, -(CH2)3-(O(CH2)2)1-OCH2CH3, -(CH2)3-(O(CH2)2)2-OCH2CH3, -(CH2)3-(O(CH2)2)3-OCH2CH3, -(CH2)3-(O(CH2)2)4-OCH2CH3, -(CH2)3-(O(CH2)2)5-OCH2CH3, -(CH2)3-(O(CH2)2)6-OCH2CH3, -(CH2)3-(O(CH2)2)7-OCH2CH3, -(CH2)3-(O(CH2)2)8-OCH2CH3, -(CH2)3-(O(CH2)2)9-OCH2CH3, -(CH2)3-(0(CH2)2)io-OCH2CH3, -(CH2)4-(O(CH2)2)i-OCH2CH3, -(CH2)4-(O(CH2)2)2-OCH2CH3, -(CH2)4-(O(CH2)2)3-OCH2CH3, -(CH2)4-(O(CH2)2)4-OCH2CH3, <CH2MO(CH2)2)5-OCH2CH3, -(CH2)4-(O(CH2)2)6-OCH2CH3, -(CH2)4-(O(CH2)2)7-OCH2CH3, <CH2MO(CH2)2)8-OCH2CH3, -(CH2)4-(O(CH2)2)9-OCH2CH3, -(CH2)4-(0(CH2)2)io-OCH2CH3, -CH2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)3)4-OCH2CH2CH3, -CH2-(O(CH2)3)5-OCH2CH2CH3, -CH2-(O(CH2)3)6-OCH2CH2CH3, -CH2-(O(CH2)3)7-OCH2CH2CH3, -CH2-(O(CH2)3)8-OCH2CH2CH3, -CH2-(O(CH2)3)9-OCH2CH2CH3,   -CH2-(0(CH2)3)io-OCH2CH2CH3,   -(CH2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)2-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)3)3-OCH2CH2CH3, -(CH2)2-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)2-(O(CH2)3)6-OCH2CH2CH3, -(CH2)2-(O(CH2)3)7-OCH2CH2CH3, -(CH2)2-(O(CH2)3)8-OCH2CH2CH3, -(CH2)3-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)3)3-OCH2CH2CH3, -(CH2)3-(O(CH2)3)4-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)5-OCH2CH2CH3,    -(CH2)3-(O(CH2)3)6-OCH2CH2CH3, -(CH2)3-(O(CH2)3)7-OCH2CH2CH3, -(CH2)3-(O(CH2)3)8-OCH2CH2CH3, -ch2-o-(CH2)2-O-(CH2)2-CH3, -CH2-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -CH2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,    -CH2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-O-(CH2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -(CH2)2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-O-(CH2)2-O-(CH2)2CH3, -(CH2)3-(O(CH2)2)2-(O(CH2)3)i-OCH2CH2CH3, -(CH2)3-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,   -(CH2)3-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3,   -CH2-O-(CH2)3-O-CH2CH3, -CH2-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, -CH2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -ch2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -CH2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)2-O-(CH2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, -(CH2)2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)3-O-(CH2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)2-(O(CH2)2)i-O-CH2CH3, -(CH2)3-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)3-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -CH2-O-(CH2)2-O-CH3, -(CH2)2-O-(CH2)2-O-CH3, -(CH2)2-(O(CH2)2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)3-O-(CH2)2CH3, <CH2MO(CH2)2)4-O-(CH2)2CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)4CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)5CH3, -(CH2)i-N(Re)-CH3, -(CH2)i-N(Re)-(CH2)i-CH3, -(CH2)i-N(Re)-(CH2)2-CH3, -(CH2)i-N(Re)-(CH2)3-CH3, -(CH2)i-N(Re)-(CH2)4-CH3, -(CH2)i-N(Re)-(CH2)5-CH3, -(CH2)i-N(Re)-(CH2)6-CH3, -(CH2)i-N(Re)-(CH2)7-CH3, -(CH2)i-N(Re)-(CH2)8-CH3, -(CH2)i-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-CH3, -(CH2)2-N(Re)-(CH2)i-CH3, -(CH2)2-N(Re)-(CH2)2-CH3, -(CH2)2-N(Re)-(CH2)3-CH3, -(CH2)2-N(Re)-(CH2)4-CH3, -(CH2)2-N(Re)-(CH2)5-CH3, -(CH2)2-N(Re)-(CH2)6-CH3, -(CH2)2-N(Re)-(CH2)7-CH3, -(CH2)2-N(Re)-(CH2)8-CH3, -(CH2)2-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-(CH2)io-CH3, -(CH2)2-N(Re)-(CH2)ii-CH3, -(CH2)3-N(Re)-CH3, -(CH2)3-N(Re)-(CH2)i-CH3, -(CH2)3-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-CH3, -(CH2)4-N(Re)-(CH2)i-CH3, -(CH2)4-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-CH3, -(CH2)5-N(Re)-(CH2)i-CH3, -(CH2)5-N(Re)-(CH2)2-CH3, -(CH2)5-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-(CH2)4-CH3, -(CH2)6-N(Re)-CH3, -(CH2)6-N(Re)-(CH2)i-CH3, -(CH2)6-N(Re)-(CH2)2-CH3, -(CH2)7-N(Re)-CH3, -(CH2)7-N(Re)-(CH2)i-CH3, -(CH2)7-N(Re)-(CH2)2-CH3, -(CH2)8-N(Re)-CH3, -(CH2)8-N(Re)-(CH2)i-CH3, -(CH2)8-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-CH3, -CH(CH3)-N(Re)-(CH2)i-CH3, -CH(CH3)-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-(CH2)3-CH3, -CH(CH3)-N(Re)-(CH2)4-CH3, -CH(CH3)-N(Re)-(CH2)5-CH3, -CH(CH3)-N(Re)-(CH2)6-CH3, -CH(CH3)-N(Re)-(CH2)7-CH3, -CH(CH3)-N(Re)-(CH2)8-CH3, -CH(CH3)-N(Re)-(CH2)9-CH3, -CH2C(O)NHCH3, -(CH2)2C(O)NHCH2CH3, (CH2)2C(O)NH(CH2)3-CH3,    -(CH2)2C(O)NH(CH2)4-CH3,(CH2)3C(O)NH(CH2)3-CH3,    -(CH2)4C(O)NH(CH2)3-CH3,(CH2)6C(O)NH(CH2)6-CH3,    -(CH2)6C(O)NH(CH2)5-CH3,(CH2)8C(O)NH(CH2)7-CH3,   U-(CH2)9C(O)NH(CH2)8-CH3,(CH2)2C(O)NH(CH2)2-O-CH2-CH3, -CH2NHC(O)CH3, (CH2)2NHC(O)(CH2)2-CH3,    -(CH2)2NHC(O)(CH2)3-CH3,(CH2)3NHC(O)(CH2)2-CH3,    -(CH2)3NHC(O)(CH2)3-CH3,(CH2)5NHC(O)(CH2)4-CH3,    -(CH2)6NHC(O)(CH2)6-CH3,(CH2)7NHC(O)(CH2)6-CH3,    -(CH2)8NHC(O)(CH2)7-CH3,-(CH2)2C(O)NH(CH2)2-CH3,-(CH2)3C(O)NH(CH2)2-CH3,-(CH2)5C(O)NH(CH2)4-CH3,-(CH2)7C(O)NH(CH2)6-CH3,-(CH2)ioC(0)NH(CH2)9-CH3,-(CH2)2NHC(O)CH2CH3,-(CH2)2NHC(O)(CH2)4-CH3,-(CH2)4NHC(O)(CH2)3-CH3,-(CH2)6NHC(O)(CH2)5-CH3,-(CH2)9NHC(O)(CH2)8-CH3,(CH2)ioNHC(0)(CH2)9-CH3, -(CH2)4NHC(O)(CH2)7-CH3, -(CH2)2NHC(O)(CH2)2-O-CH2-CH3, -(CH2)4NHC(O)CH3, -CH2-piperidinylene-CH3, -CH2-piperidinylene-CH2-CH3, -CH2-piperidinylene-(CH2)2-CH3, -CH2-piperidinylene-(CH2)3-CH3, -CH2-piperidinylene-(CH2)4-CH3, -CH2-piperidinylene-(CH2)5-CH3, -CH2-piperidinylene-(CH2)6-CH3, -CH2-piperidinylene-(CH2)7-CH3, -(CH2)2-piperidinylene-CH3, -(CH2)2-piperidinylene-CH2-CH3, -(CH2)2-piperidinylene-(CH2)2-CH3, -(CH2)2-piperidinylene-(CH2)3-CH3, -(CH2)2-piperidinylene-(CH2)4-CH3, -(CH2)2-piperidinylene-(CH2)s-CH3, -(CH2)2-piperidinylene-(CH2)6-CH3, -(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)3-piperidinylene-CH3, -(CH2)3-piperidinylene-CH2-CH3, -(CH2)3-piperidinylene-(CH2)2-CH3, -(CH2)3-piperidinylene-(CH2)3-CH3, -(CH2)3-piperidinylene-(CH2)4-CH3, -(CH2)3-piperidinylene-(CH2)5-CH3, -(CH2)3-piperidinylene-(CH2)6-CH3, -(CH2)3-piperidinylene-(CH2)7-CH3, -(CH2)4-piperidinylene-CH3, -(CH2)4-piperidinylene-CH2-CH3, -(CH2)4-piperidinylene-(CH2)2-CH3, -(CH2)4-piperidinylene-(CH2)3-CH3, -(CH2)4-piperidinylene-(CH2)4-CH3, -(CH2)4-piperidinylene-(CH2)5-CH3, -(CH2)4-piperidinylene-(CH2)6-CH3, -(CH2)4-piperidinylene-(CH2)7-CH3, -(CH2)5-piperidinylene-CH3, -(CH2)5-piperidinylene-CH2-CH3, -(CH2)5-piperidinylene-(CH2)2-CH3, -(CH2)5-piperidinylene-(CH2)3-CH3, -(CH2)5-piperidinylene-(CH2)4-CH3, -(CH2)5-piperidinylene-(CH2)5-CH3, -(CH2)s-piperidinylene-(CH2)6-CH3, -(CH2)5-piperidinylene-(CH2)7-CH3, -(CH2)6-piperidinylene-CH3, -(CH2)6-piperidinylene-CH2-CH3, -(CH2)6-piperidinylene-(CH2)2-CH3, -(CH2)6-piperidinylene-(CH2)3-CH3, -(CH2)6-piperidinylene-(CH2)4-CH3, -(CH2)6-piperidinylene-(CH2)5-CH3, -(CH2)6-piperidinylene-(CH2)6-CH3, -(CH2)6-piperidinylene-(CH2)7-CH3, -(CH2)7-piperidinylene-CH3, -(CH2)7-piperidinylene-CH2-CH3, -(CH2)7-piperidinylene-(CH2)2-CH3, -(CH2)7-piperidinylene-(CH2)3-CH3, -(CH2)7-piperidinylene-(CH2)7-CH3, -(CH2)8-piperidinylene-CH3, -(CH2)8-piperidinylene-CH2-CH3, -(CH2)8-piperidinylene-(CH2)2-CH3, -(CH2)8-piperidinylene-(CH2)3-CH3, -(CH2)8-piperidinylene-(CH2)4-CH3, -(CH2)8-piperidinylene-(CH2)5-CH3, -(CH2)8-piperidinylene-(CH2)6-CH3, -(CH2)8-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -CH2-N(Rj-CH2-piperidm                 -CH2-N(Re)-(CH2)2-piperidinylene-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH2-CH3,(CH2)2-piperidinylene-(CH2)2-CH3,(CH2)2-piperidinylene-(CH2)4-CH3,(CH2)2-piperidinylene-(CH2)6-CH3,-CH2-N(Re)-(CH2)2-piperidinylene-(CH2)3-CH3,-CH2-N(Re)-(CH2)2-piperidinylene-(CH2)5-CH3,-CH2-N(Re)--CH2-N(Re)--CH2-N(Re)--CH2-N(Re)-(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3, piperidinylene-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-CH2-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)3-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)5-CH3,-(CH2)2-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)3-N(Re)-CH2-piperidinylene-CH2-CH3,piperidinylene-(CH2)2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)7-CH3,piperidinylene-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)2-CH3, piperidinylene-CH3,piperidinylene-(CH2)2-CH3, piperidinylene-(CH2)4-CH3, piperidinylene-(CH2)6-CH3,-(CH2)4-N(Re)-CH2-piperidinylene-CH2-CH3,-(CH2)4-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)5-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)6-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)7-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-CH2-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH2)3-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH2)5-CH3,-(CH2)8-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-(CH2)2-N(Re)-CH2--(CH2)2-N(Re)-CH2--(CH2)2-N(Re)-CH2--(CH2)3-N(Re)-CH2--(CH2)3-N(Re)-CH2--(CH2)4-N(Re)-CH2--(CH2)4-N(Re)-CH2--(CH2)5-N(Re)-CH2--(CH2)6-N(Re)-CH2--(CH2)7-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--(CH2)8-N(Re)-CH2--CH2-piperazinylene-CH3, -CH2-piperazinylene-CH2-CH3, -CH2-piperazinylene-(CH2)2-CH3, -CH2-piperazinylene-(CH2)3-CH3, -CH2-piperazinylene-(CH2)4-CH3, -CH2-piperazinylene-(CH2)5-CH3, -CH2-piperazinylene-(CH2)6-CH3, -CH2-piperazinylene-(CH2)7-CH3, -(CH2)2-piperazinylene-CH3, -(CH2)2-piperazinylene-CH2-CH3, -(CH2)2-piperazinylene-(CH2)2-CH3, -(CH2)2-piperazinylene-(CH2)3-CH3, -(CH2)2-piperazinylene-(CH2)4-CH3, -(CH2)2-piperazinylene-(CH2)5-CH3, -(CH2)2-piperazinylene-(CH2)6-CH3,-(CH2)2-piperazinylene-(CH2)?-CH3, -(CH2)3-piperazinylene-CH3, -(CH2)3-piperazinylene-CH2-CH3, -(CH2)3-piperazinylene-(CH2)2-CH3, -(CH2)3-piperazinylene-(CH2)3-CH3, -(CH2)3-piperazinylene-(CH2)4-CH3, -(CH2)3-piperazinylene-(CH2)5-CH3, -(CH2)3-piperazinylene-(CH2)6-CH3, -(CH2)3-piperazinylene-(CH2)7-CH3, -(CH2)4-piperazinylene-CH3, -(CH2)4-piperazinylene-CH2-CH3, -(CH2)4-piperazinylene-(CH2)2-CH3, -(CH2)4-piperazinylene-(CH2)3-CH3, -(CH2)4-piperazinylene-(CH2)4-CH3, -(CH2)4-piperazinylene-(CH2)5-CH3, -(CH2)4-piperazinylene-(CH2)6-CH3, -(CH2)4-piperazinylene-(CH2)7-CH3, -(CH2)5-piperazinylene-CH3, -(CH2)s-piperazinylene-CH2-CH3, -(CH2)5-piperazinylene-(CH2)2-CH3, -(CH2)5-piperazinylene-(CH2)3-CH3, -(CH2)s-piperazinylene-(CH2)4-CH3, -(CH2)s-piperazinylene-(CH2)5-CH3, -(CH2)s-piperazinylene-(CH2)6-CH3, -(CH2)s-piperazinylene-(CH2)7-CH3, -(CH2)6-piperazinylene-CH3, -(CH2)6-piperazinylene-CH2-CH3, -(CH2)6-piperazinylene-(CH2)2-CH3, -(CH2)6-piperazinylene-(CH2)3-CH3, -(CH2)6-piperazinylene-(CH2)4-CH3, -(CH2)6-piperazinylene-(CH2)s-CH3, -(CH2)6-piperazinylene-(CH2)6-CH3, -(CH2)6-piperazinylene-(CH2)7-CH3, -(CH2)7-piperazinylene-CH3, -(CH2)7-piperazinylene-CH2-CH3, -(CH2)7-piperazinylene-(CH2)2-CH3, -(CH2)7-piperazinylene-(CH2)3-CH3, -(CH2)7-piperazinylene-(CH2)7-CH3, -(CH2)8-piperazinylene-CH3, -(CH2)8-piperazinylene-CH2-CH3, -(CH2)8-piperazinylene-(CH2)2-CH3, -(CH2)8-piperazinylene-(CH2)3-CH3, -(CH2)8-piperazinylene-(CH2)4-CH3, -(CH2)8-piperazinylene-(CH2)s-CH3, -(CH2)s-piperazinylene-(CH2)6-CH3, or -(CH2)8-piperazinylene-(CH2)7-CH3;wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene , optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof;a hydrogen atom of CH3 of the groups and a hydrogen atom of one or more CH2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof;each Re independently represents H or C1-6 alkyl; andnl, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

28. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-27, wherein -Rf-LIN-represents the following groups:-CH2-, -0-CH2-**, -NHC(O)-CH2-**, -C(O)NH-CH2-**, -NH-CH2-**, -N(CH3)-CH2-**, -N(CH3)-(CH2)2-N(CH3)-CH2-**, -N(CH3)-(CH2)3-N(CH3)-CH2-**, -NH-(CH2)2-N(CH3)-CH2-**, -N(CH3)-(CH2)3-NH-CH2-**, -CH2-NHC(O)-CH2-**, -CH2-C(O)NH-CH2-**, -CH2-NH-CH2-**, -O-(CH2)2-N(CH3)-CH2-**, -O-(CH2)2-NH-CH2-**, or -CH2-N(CH3) -CH2-**, or**** ** ** ** ******** ** **** ** ** ** ****nwherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated Ci-6 alkyl, optionally halogenated Ci-6 alkyl, Ci-6 alkoxy, halogenated Ci-6 alkoxy, deuterated Ci-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or any combination thereof; and symbol ** indicates the point of attachment to ULM.

29. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, which is also of Formula (II-l), Formula (11-2), Formula (11-3), Formula (11-4), Formula (11-5), Formula (II-6), Formula (11-7), Formula (II-8), Formula (II-9), Formula (II-10), Formula (II-l 1), Formula (11-12), Formula (11-13), Formula (11-14), Formula (11-15), Formula (11-16), Formula (11-17), Formula (11-18), Formula (II-19), Formula (11-20), Formula (11-21), Formula (11-22), Formula (11-23), Formula (11-24), Formula (11-25), Formula (11-26), Formula (11-27), Formula (11-28), Formula (11-29), Formula (11-30), Formula (11-31), Formula (11-32), Formula (11-33), Formula (11-34), Formula (11-35), Formula (II-36), Formula (11-37), Formula (11-38), Formula (11-39), Formula (11-40), Formula (11-41), Formula (11-42), Formula (11-43), Formula (11-44), Formula (11-45), Formula (11-46), Formula (11-47), Formula (11-48), Formula (11-49), Formula (11-50), Formula (11-51), Formula (11-52), Formula (II-53), Formula (11-55), Formula (11-56), Formula (11-57), Formula (11-58), Formula (11-59), Formula (11-60), Formula (11-61), Formula (11-62), Formula (11-63), Formula (11-64), Formula (11-65), or Formula (11-66):Formula (11-1)Formula (II-2)Formula (11-8)oFormula (11-7)p4s(^13^)Formula (II-58)Formula (II-57)Formula (II-63)Formula (II-64)Formula (II-65)Formula (II-66)                 .wherein A, Rb R2, R3, R4, (Rb)n, LIN, Rf, (R1^, (R2)p2, (R4)p3, (R5)p4, (R7)p5, R8, (R9)p6, R10, (Rn)P7, R12, R13, R14, ring A, ring B, ring C, R15, (R16)p9, Xb X2, X3, (R2O)pio, R21, R22, (R23)ph, (R24)Pi2, R25, X4, X5, X6, X7, R28, R29, R30, R31, R32, R33, (R34)pi3, R35, (R36)pi4, R37, X8, X9, Xio, Xn, Xi2, R38, R39, (R4O)P15, (R42)P16, (R43)P17, (R44)P18, (R45)pi9, (R46)p2o, (R48)p2b (R49)p22, R50, R51, (R52)p23, (R53)p24, R54, r55 R56 R57 (R58)p2s     R59 R60, R61 R62 R63 R64,         R66, R67 R68, R69, R70           r73R74, R75, R76, R77, R78, R79, R80, R81, Xi6, Xi7, R82, R83, R84, R85, R86, R87, R88, R89, R90, (R91)p27, (R92)p28, (R93)p29, R94, R95, (R96)p30, (R97)p3b X18, X19, X20, X2b X22, R98, R99, R100, R101, R102, R103, X23, (R104)p32, (R105)p33, (R106)p34, (R107)p35, (R108)p36, (R109)p37, (R110)p38, (Rin)p39, R112, R113, R114, R115, R116, R117, R118, (R119)p40, R120, R121, R122, R123, (R125)^, (R127)p43, R131, R132, (R133)^, (R134)p47, (R135)p48, R136, (R137)p49, X24, X25, X26, R138, R139, R140, (R141)P50, R142, (R143)P5b (R144)p52, (R145)p53, (R146)p54, Rf2, (R147)p55, R148, (R149)p56, X27, ring I, R150, (R151)p57, (R152)P58, (R153)p59, X28, X29, X30, (R154)p6o, R155, R156, R157, R158, (R159)P6b X3b (R160)P62, ring J and (R161)P63 are as defined in claim 13.

30. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, which is selected from:N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;N-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S, 10aR)-8-(((2S)-5-amino-l-(2-chloro-3-(4-((2-(2,6-dioxopiperi din-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S, 10aR)-8-(((2S)-5-amino-l-(2-chloro-3-(4-((2-(2,6-dioxopiperi din-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((2S)-5-amino-l-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((1 -((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[l,2-a][l,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((1 -((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5]diazocin-5-yl)carbamoyl)-lH-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5] diazocin-5 -yl)carbamoyl)-1 H-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperi din-3-yl)-4-fluoro-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5] diazocin-5 -yl)carbamoyl)-1 H-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperi din-3-yl)-6-fluoro-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[ 1,2-a] [ 1,5] diazocin-5 -yl)carbamoyl)-1 H-indol-5-yl)difluoromethyl)phosphonic acid;((2-(((5S,8S,10aR)-8-(((S)-5-amino-l-(benzhydrylamino)-l,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-3 -oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo [ 1,2-a] [ 1,5] diazocin-5 -yl)carbamoyl)-1 H-indol-5-yl)difluoromethyl)phosphonic acid;6-(1 -((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -y 1)-2-(4-phenoxyphenyl)nicotinamide;6-(4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(1 -((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(1 -((2-(2,6-dioxopiperi din-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperi din-4-yl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;6-(4-(1 -((2-(2,6-dioxopiperi din-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperi din-4-yl)piperazin-1 -yl)-2-(4-phenoxyphenyl)nicotinamide;3 -(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(((2-(2,6-di oxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(((2-(2,6-di oxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(((2-(2,6-di oxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(((2-(2,6-di oxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-buty l)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)- lH-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)-1 H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3 -(tert-butyl)-N-(4-(5-(4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)phenyl)-1 H-indazol-3 -yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide;3-(5-((4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3 -yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((3-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)azetidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(((l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(((l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(((l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-5-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-(((l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2'-(7,7-dimethyl-l-oxo-l,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[l,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-l-methyl-6-oxo-l,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3R,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3R,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3R,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3R,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4R)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4R)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4R)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4R)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluoropiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluoropiperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluoropiperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)-3-fluoropiperidin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-(((3 S,4S)-4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)piperidin-1 -yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-amino-3 -(4-phenoxyphenyl)-1 H-pyrazolo [3,4-d]pyrimidin-1 -yl)-3 -fluoropiperidin-1 -yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-( 1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-( 1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-( 1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-( 1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-( 1 -(4-hydroxyphenyl)-2-phenylbut-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(4-(l -(4-hydroxyphenyl)-2-phenylbut-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(4-(l -(4-hydroxyphenyl)-2-phenylbut-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(4-(l -(4-hydroxyphenyl)-2-phenylbut-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1 -(4-hydroxyphenyl)-2-phenylbut-1 -en- l-yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1 -(4-hydroxyphenyl)-2-phenylbut-1 -en- l-yl)phenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1 -(4-hydroxyphenyl)-2-phenylbut-1 -en- l-yl)phenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-chloro-1 -(4-hydroxyphenyl)-2-phenylbut-1 -en- l-yl)phenyl)piperazin-1 -yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenoxy)ethyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenoxy)ethyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenoxy)ethyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-l -en-1 -yl)phenoxy)ethyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-(4-(( 1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-(4-(( 1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(4-((lR, 2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3 S,4R)-7-hydroxy-3-phenyl chroman-4-yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-((3S, 4R)-7-hydroxy-3-phenyl chroman-4-yl)phenyl)piperi din-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-(((l-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-(((l-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((( 1 -(4-((3 S,4R)-7-hydroxy-3 -phenylchroman-4-yl)pheny l)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(l-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(l-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-( 1 -(4-((3 S,4R)-7-hydroxy-3 -phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(4-((lR,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((( 1-(4-((1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((( 1-(4-((1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((( 1-(4-((1 R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1 -yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(3-(2,3-dichlorophenyl)-lH-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(3-(2,3-dichlorophenyl)-lH-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(3-(2,3-dichlorophenyl)-lH-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(3-(2,3-dichlorophenyl)-lH-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-(6-(4-amino-4-methylpiperi din-1 -yl)-1 H-pyrazolo [3,4-b]pyr azin-3 -yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-(6-(4-amino-4-methylpiperi din-1 -yl)-1 H-pyrazolo [3,4-b]pyr azin-3 -yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-(6-(4-amino-4-methylpiperi din-1 -yl)-1 H-pyrazolo [3,4-b]pyr azin-3 -yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-(6-(4-amino-4-methylpiperi din-1 -yl)-1 H-pyrazolo [3,4-b]pyr azin-3 -yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-l-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-l-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-l-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-l-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3-((3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3-((3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3-((3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((3-((3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(3 -(3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(3 -(3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(3 -(3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(3 -(3 -amino-5-(4-amino-4-methylpiperidin-1 -yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((2,3 -difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methy 1)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((2,3 -difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((2,3 -difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((2,3 -difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazine-3-carboxamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)nicotinamide;N-((lr,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)nicotinamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chi oro-4-cyanophenoxy)cyclohexyl)-6-(3 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide;N-(( 1 r,4r)-4-(3 -chi oro-4-cyanophenoxy)cyclohexyl)-6-(3 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3 -carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;N-((lr,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazine-3-carboxamide;3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-l-yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((5-methoxy-4-((4-( 1 -methyl-1 H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-(((5-methoxy-4-((4-( 1 -methyl-1 H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-(((5-methoxy-4-((4-( 1 -methyl-1 H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-(((5-methoxy-4-((4-( 1 -methyl-1 H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-( 1 -methyl-1 H-indol-3 -yl)pyrimidin-2-yl)amino)phenyl)acrylamide;3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)quinazolin-6-yl)acrylamide;N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)quinazolin-6-yl)acrylamide;3-(5-(((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methy 1)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3,4-di chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methy 1)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3,4-di chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methy 1)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3,4-di chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methy 1)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1 -yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-((3 -chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enamide;(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)but-2-enamide;2-(7-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)amino)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(7-(((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)amino)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(7-(((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)amino)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(7-(((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)amino)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-1 -oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;2-(6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridazin-3-yl)-l-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide;3-(1 -oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11 -oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1 (4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-1 -oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11 H,51H-11 -oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-1 -oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11 H,51H-11 -oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-1 -oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11 H,51H-11 -oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(l-oxo-5-((4-((R,E)-l1,26,7-trimethyl-3-oxo-52,53-dihydro-l1H,51H-l l-oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-1 (4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-1 -oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11 -oxa-4-aza-5(2,l)-benzo[d]imidazola-2(2,4)-pyridina-l(4,5)-pyrazolacycloundecaphane-56-yl)piperazin-l-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-1 -oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11 -oxa-4-aza-5(2, l)-benzo[d]imidazola-2(2,4)-pyridina-1 (4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-1 -oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-1 ^,5^-11 -oxa-4-aza-5(2, l)-benzo[d]imidazola-2(2,4)-pyridina-1 (4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperazin-l-yl)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-lH-pyrazolo[4,3-c]pyridin-3-yl)piperazin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(6-((2-(1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((2-( 1 -(cyclopropylsulfonyl)-1 H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1 -isopropyl-1 H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3-c]pyridin-3-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1 H-pyrazolo [4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-(((l-(l-isopropyl-6-((2-(4-methoxypiperidin-l-yl)pyrimidin-4-yl)amino)-lH-pyrazolo [4,3 -c]pyridin-3 -yl)piperidin-4-yl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-( 1 -(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-( 1-(1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(4-( 1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-(4-( 1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-(4-( 1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-(4-( 1 -isopropyl-6-((2-(4-methoxypiperidin-1 -yl)pyrimidin-4-yl)amino)-1H-pyrazolo [4,3 -c]pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-l-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1 '-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-r-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-r-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-r-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)- [ 1,4'-bipiperidine] -4-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-l-carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1 -carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1 -carboxamide;N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-( 1 -((2-(2,6-dioxopiperidin-3 -y 1)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1 -carboxamide;4-(2,6-dichlorobenzamido)-N-(l-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-lH-pyrazole-3-carboxamide;4-(2,6-dichlorobenzamido)-N-(l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-lH-pyrazole-3-carboxamide;4-(2,6-dichlorobenzamido)-N-(l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-lH-pyrazole-3-carboxamide;4-(2,6-dichlorobenzamido)-N-(l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-lH-pyrazole-3-carboxamide;N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo [ 1,2-b]pyrazol-3 -yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo [ 1,2-b]pyrazol-3 -yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo [ 1,2-b]pyrazol-3 -yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo [ 1,2-b]pyrazol-3 -yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide;N-(5-cyclobutyl-1 H-pyrazol-3 -yl)-2-(4-((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-y l)methoxy)pheny l)acetamide;N-(5-cyclobutyl-lH-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methoxy)phenyl)acetamide;N-(5-cyclobutyl-lH-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methoxy)phenyl)acetamide;N-(5-cyclobutyl-lH-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methoxy)phenyl)acetamide;3 -(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1 -methyl-1 H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1 -methyl-1 H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1 -methyl-1 H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1 -methyl-1 H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-l-hydroxybutan-2-yl)amino)-3-isopropylpyrazolo[ 1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide;4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1 -hydroxybutan-2-yl)amino)-3 -isopropylpyrazolo [ 1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide;4-((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1 -hydroxybutan-2-yl)amino)-3 -isopropylpyrazolo [ 1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide;4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1 -hydroxybutan-2-yl)amino)-3 -isopropylpyrazolo [ 1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide;4-(((4-(5-chloro-2-(( 1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((4-(5-chloro-2-(( 1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((4-(5-chloro-2-(( 1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((4-(5-chloro-2-(( 1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((5'-chloro-2'-((l-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((5'-chloro-2'-((l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((5'-chloro-2'-((l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-(((5'-chloro-2'-((l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide;3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide;3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide;3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide;N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;4-((4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)-6-methoxy quinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)-6-methoxy quinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)-6-methoxy quinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)propoxy)-6-methoxy quinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile;N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethyny 1)-4-methylbenzamide;N-(4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethyny 1)-4-methylbenzamide;N-(4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethyny 1)-4-methylbenzamide;N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[l,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[ 1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide;2-(4-((3S)-l-((2-(2,6-dioxopiperi din-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-3-yl)pheny 1)-2H-indazole-7-carboxamide;2-(4-((3S)-1-((2-(2,6-dioxopiperi din-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperi din-3-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-((3S)-l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-((3S)-l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(1 -((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(1 -((2-(2,6-dioxopiperi din-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperi din-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(1 -((2-(2,6-dioxopiperi din-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperi din-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-2H-indazole-7-carboxamide;2-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)phenyl)-2H-indazole-7-carboxamide;3-(5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-l-yl)methyl)benzoyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((4-(8-fluoro-l-oxo-2,3,4,6-tetrahydro-lH-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-(((4-(8-fluoro-l-oxo-2,3,4,6-tetrahydro-lH-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-(((4-(8-fluoro-l-oxo-2,3,4,6-tetrahydro-lH-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-(((4-(8-fluoro-l-oxo-2,3,4,6-tetrahydro-lH-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-fluoro-5-((8S,9R)-5-fhioro-9-(l-methyl-lH-l,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-lH-l,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(4-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(l-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5 -yl)methyl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5 -yl)methyl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5 -yl)methyl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-( 1 -((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-( 1 -((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-( 1 -((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-((5-(4-( 1 -((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;3 -(5-((4-((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-di one;3 -(4-fluoro-5-((( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-( 1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-( 1 -(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((5-fluoro-4-(4-fluoro-l-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(4-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(6-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(7-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d] imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3 -(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1 -isopropyl-2-methyl-1 H-benzo [d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3 -yl)methyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimi din-2-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimi din-2-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimi din-2-yl)amino)pyridin-3-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimi din-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-di one;3-(5-(((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3 -yl)piperazin-1 -yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-((4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-l-oxoisoindolin-5-yl)methy l)piperazin-1 -yl)piperidin-l-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;3 -((4-(4-(4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;3-(5-(((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-di one;3-(5-(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-di one;3-(5-(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-di one;3-(5-(((1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3 -methoxyphenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichl oro-3-fluorophenyl)ethoxy)pyri din-3-yl)-lH-pyr azol-1-yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichl oro-3-fluorophenyl)ethoxy)pyri din-3-yl)-lH-pyr azol-1-yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-lH-pyr azol-1-yl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;8-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,1 l-dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-9-ethyl-6,6-dimethyl-l l-oxo-6,1 l-dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-9-ethyl-6,6-dimethyl-l l-oxo-6,1 l-dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-9-ethyl-6,6-dimethyl-l l-oxo-6,1 l-dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-9-ethyl-6,6-dimethyl-l l-oxo-6,1 l-dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;8-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-9-ethyl-6,6-dimethyl-11 -oxo-6,11 -dihydro-5H-benzo[b]carbazole-3-carbonitrile;3-(5-((4-(1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1 -(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(l-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;(4R)-26-amino-11 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-l 1H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5( 1,2)-benzenacyclooctaphane-15-carbonitrile;(4R)-26-amino-11 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-l1H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(l,2)-benzenacyclooctaphane-l5-carbonitrile;(4R)-26-amino-11 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-l1H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(l,2)-benzenacyclooctaphane-l5-carbonitrile;(4R)-26-amino-11 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-l1H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(l,2)-benzenacyclooctaphane-l5-carbonitrile;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)acetamide;2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethyl)acetamide;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4] diazepin-6-yl)acetyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)acetyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)acetyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)acetyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)ethyl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)ethyl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione ;3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)ethyl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [ 1,4]diazepin-6-yl)ethyl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-l-yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-l-yl)methyl)-5-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-l-yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-(((1 -(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1 -yl)methyl)-7-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione;4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(5 -((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(5 -((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-N-(5 -((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahy dropyrrolo [3,4-c]pyr azol-3-yl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;4-(4-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide;N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-(l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-buty 1)-3 -((2-((4-(4-( 1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(l-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(l-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(l-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(l-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide;2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifhioromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifhioromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)amino)piperidin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-y l)amino) -N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-y l)amino) -N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-y l)amino) -N-methylbenzamide;2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-y l)amino) -N-methylbenzamide;2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N -methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)piperidin-l-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-1 -yl)piperidin-1 -yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide;2-(2-((cyclopropyhnethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-lH-pyrazol-4-yl)oxazole-4-carboxamide;2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)oxazole-4-carboxamide;2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)oxazole-4-carboxamide;2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1 -(1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)oxazole-4-carboxamide;N-(3 -(difluoromethyl)-1-(1 -((2-(2,6-dioxopiperidin-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)-5-morpholinopyrazolo [ 1,5-a]pyrimidine-3 -carboxamide;N-(3 -(difluoromethyl)-1-(1 -((2-(2,6-dioxopiperidin-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)-5-morpholinopyrazolo [1,5 -a]pyrimidine-3 -carboxamide;N-(3 -(difluoromethyl)-1-(1 -((2-(2,6-dioxopiperidin-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)-5-morpholinopyrazolo [1,5 -a]pyrimidine-3 -carboxamide;N-(3 -(difluoromethyl)-1-(1 -((2-(2,6-dioxopiperidin-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1 H-pyrazol-4-yl)-5-morpholinopyrazolo [1,5 -a]pyrimidine-3 -carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-5-((R)-3-hydroxypyrrolidin-l-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-5-((R)-3-hydroxypyrrolidin-l-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-5-((R)-3-hydroxypyrrolidin-l-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide;N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperazin-l-yl)-5-((R)-3-hydroxypyrrolidin-l-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide;4-(( 1 -((2-(2,6-dioxopiperidin-3-yl)-1 -oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-1 -(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide;4-((1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-l-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide;4-((1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-l-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide;4-((1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-l-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-l-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide;6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridin-3 -yl)-l-isopropyl-N-((6-methyl-2-oxo-4-propyl-l,2-dihydropyridin-3-yl)methyl)-lH-indazole-4-carboxamide;6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-4-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridin-3 -yl)-1 -isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyri din-3 -y l)methy 1)-1H-indazole-4-carboxamide;6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-6-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridin-3 -yl)-1 -isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyri din-3 -yl)methy 1)-1H-indazole-4-carboxamide;6-(6-(4-((2-(2,6-dioxopiperi din-3 -yl)-7-fluoro-1 -oxoisoindolin-5-yl)methyl)piperazin-1 -yl)pyridin-3 -yl)-1 -isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyri din-3 -yl)methy 1)-1H-indazole-4-carboxamide;6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)pyridin-3 -yl)-1 -isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyri din-3 -yl)methy 1)-1H-indazole-4-carboxamide;6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-l-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1 ...