Alkoxy heteroaryl- carboxamide or thioamide compounds

Abstract

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

Description

The present invention relates to pesticidally active, in particular insecticidally active alkoxy heteroarylcarboxamide or thioamide compounds, preferably substituted pyridinyl, pyrazinyl, or pyridazinyl compounds thereof, to processes fortheir preparation, to compositions comprising the compounds, and to their use for controlling animal pests, including arthropods and in particular insects. WO2021153720 describes certain alkoxy benzoic acid amide derivatives. There have now been found certain novel pesticidally active alkoxy and cycloalkoxy heteroarylcarboxamide or thioamide compounds. The present invention accordingly relates, in a first aspect, to a compound of the formula (I) wherein: A is O, or S; X is N, orCR8; Y is N or CR8; Z is N or CR8; with the provision that at least one of X, Y, Z is N; R1 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, Cs-Ce-cycloalkyl, Cs-Ce-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-Ce-haloalkynyl, Ci-Ce-alkoxy, Ci-Ce-haloalkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, Cs-Ce-cycloalkyl-Ci-Ce-alkyl, Cs-Ce-halocycloalkyl-Ci-Ce-alkyl, cyano-Ci-Ce-alkyl, cyano-Cs-Ce-cycloalkyl, cyano-Cs-Ce-cycloalkyl-Ci-Ce-alkyl, cyano-heterocycloalkyl, hydroxy-Cs-Ce-cycloalkyl, Ci-Ce-alkyl-carbonyloxy-Cs-Ce-cycloalkyl, Ci-Ce-alkylsulfonyloxy-Cs-Ce-cycloalkyl, Ci-Ce-alkoxy-Cs-Ce-cycloalkyl, C1-Ce-haloalkoxy-Cs-Ce-cycloalkyl, Ci-Ce-alkylthio-Cs-Ce-cycloalkyl, Ci-Ce-haloalkylthio-Cs-Ce-cycloalkyl, C1-Ce-alkylsulfinyl-Cs-Ce-cycloalkyl, Ci-Ce-haloalkylsulfinyl-Cs-Ce-cycloalkyl, Ci-C6-alkylsulfonyl-C3-C6-cycloalkyl, Ci-Ce-haloalkylsulfonyl-Cs-Ce-cycloalkyl, C2-C6-alkynyl-C3-C6-cycloalkyl, Ci-Ce-alkoxycarbonyl-Cs-Ce-cycloalkyl, carboxy-Cs-Ce-cycloalkyl, carbamoyl-C3-C6-cycloalkyl, Ci-C6-alkylaminocarbonyl-C3-C6-cycloalkyl (which may be mono- or poly-substituted by R8), C4-C8-bicycloalkyl, Ci-Ce-alkoxyimino, phenyl (which may be mono- or poly-substituted by R10), phenyl-Ci-Cs-alkyl (the phenyl may be mono- or polysubstituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-Ci-Cs-alkyl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-Cs-Ce-cycloalkyl (the heteroaryl may be mono- or poly-substituted by R10), heterocycloalkyl (which may be substituted by R8), heterocycloalkyl-Ci-Ce-alkyl (which may be substituted by R8), or heterocycloalkyl-Cs-Ce-cycloalkyl (the heterocycloalkyl may be substituted by R8); R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-Ce-haloalkynyl, Ci-Ce-alkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, C1-Ce-haloalkoxy, C3-C6-cycloalkyl-Ci-C6-alkyl, C3-C6-halocycloalkyl-Ci-C6-alkyl, phenyl (which may be mono-or poly-substituted by R10), phenyl-Ci-Cs-alkyl (the phenyl may be mono- or poly-substituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-Ci-Cs-alkyl (the heteroaryl may be mono-substituted or polysubstituted by R10), cyano, cyano-Ci-Ce-alkyl, cyano-Cs-Ce-cycloalkyl, hydroxy, formyl, Ci-Ce-alkylcarbonyl, Ci-Ce-alkoxycarbonyl, Cs-Ce-cycloalkylcarbonyl, benzoyl that is mono or polysubstituted by R10, Ci-Ce-haloalkoxycarbonyl, C2-C6-alkenyloxycarbonyl, carbamoyl, Ci-Ce-alkylaminocarbonyl (the amino group may be substituted by R8), Ci-Ce-alkoxycarbonyl Ci-Ce-alkylamino (the amino group may be substituted by R8), Ci-Ce-alkoxycarbonyl amino (the amino group may be substituted by R8), (Ci-C6-alkylthio)carbonyl, (Ci-C6-alkyl)thiocarbonyl, (Ci-C6-alkoxy)thiocarbonyl, thiocarbamoyl, Ci-C6-alkylamino-thiocarbonyl (the amino group may be substituted by R8), Ci-Ce-alkylsulfonyl, Ci-Ce-haloalkylsulphonyl, sulfamoyl, Ci-C6-alkylaminosulfonyl (the amino group may be substituted by R8), Ci-C6-alkoxycarbonyl-Ci-C6-alkyl, aminocarbonyl-Ci-C6-alkyl, Ci-Ce-alkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), C3-C6-cycloalkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), Ci-Ce-haloalkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), Ci-Ce-alkylcarbonyl-Ci-Ce-alkyl, Ci-Ce-haloalkylcarbonyl-Ci-Ce-alkyl, Ci-Ce-alkylcarbonyloxy-Ci-Cs-alkyl, Ci-Ce-alkoxycarbonyloxy-Ci-Ce-alkyl, Ci-C6-alkoxycarbonylamino-Ci-C6-alkyl (the amino group may be substituted by R8), hydroxyimino, hydroxyamino-Ci-C6-alkyl, Ci-C6-alkoxyimino, Ci-Ce-alkoxyimino-Ci-Ce-alkyl, or Ci-C6-haloalkoxyimino-Ci-C6-alkyl; R3 is halogen, cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, C3-C6-cycloalkyl, Ci-Ce-haloalkyl, or Ci-Ce-haloalkoxy; R5 is Ci-C3-alkylsulfonylamino, Ci-C3-haloalkylsulfonylamino, or C3-C6-cycloalkylsulfonylamino, wherein any of said amino-groups is unsubstituted or substituted by R6; and wherein any of said cycloalkyl-groups may be mono-or polysubstituted by R9; R6 is Ci-Ce-alkyl, Ci-Ce-alkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, cyano-Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Ce-alkylcarbonyl, or Ci-Ce-alkoxycarbonyl; R8 is hydrogen, halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano; R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano; and R10 is halogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, Cs-Ce-cycloalkyl, Cs-Ce-halocycloalkyl, Cs-Ce-cycloalkyl-Ci-Ce-alkyl, Cs-Ce-halocycloalkyl-Ci-Ce-alkyl, Ci-Ce-alkoxy, Ci-Ce-haloalkoxy, Ci-Ce-alkylthio, Ci-Ce-haloalkylthio, Ci-Ce-alkylsulfinyl, Ci-Ce-haloalkylsulfinyl, Ci-Ce-alkylsulfonyl, Ci-Ce-haloalkylsulphonyl, C1-C6-alkylthio-Ci-C6-alkyl, Ci-C6-haloalkylthio-Ci-C6-alkyl, Ci-Ce-alkylsulfonyloxy, Ci-Ce-haloalkylsulfonyloxy, phenyl (which may be mono- or poly-substituted independently selected from halogen, Ci-Ce-alkyl and Ci-Ce-haloalkyl), phenyl-Ci-Cs-alkyl, phenyl-Ci-Ce-alkoxy, cyano, or nitro; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer and N-oxide of the compound of formula (I). Compounds of formula (I) which have at least one basic centre can form, for example, acid addition salts, for example with strong inorganic acids such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphorus acid or a hydrohalic acid, with strong organic carboxylic acids, such as Ci-C4alkanecarboxylic acids which are unsubstituted or substituted, for example by halogen, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, for example oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid, such as hydroxycarboxylic acids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or such as benzoic acid, or with organic sulfonic acids, such as Ci-C4alkane- or arylsulfonic acids which are unsubstituted or substituted, for example by halogen, for example methane- or p-toluenesulfonic acid. Compounds of formula (I) which have at least one acidic group can form, for example, salts with bases, for example mineral salts such as alkali metal or alkaline earth metal salts, for example sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower-alkylamine, for example ethyl-, diethyl-, triethyl- or dimethylpropylamine, or a mono-, di- ortrihydroxy-lower-alkylamine, for example mono-, di- or triethanolamine. In each case, the compounds of formula (I) according to the invention are in free form, in oxidized form as a N-oxide or in salt form, e.g. an agronomically usable salt form. N-oxides are oxidized forms of tertiary amines or oxidized forms of nitrogen containing heteroaromatic compounds. They are described for instance in the book “Heterocyclic N-oxides” by A. Albini and S. Pietra, CRC Press, Boca Raton 1991. The compounds of formula (I) according to the invention also include hydrates which may be formed during the salt formation. The term "Ci-Cn-alkyl” as used herein refers to a saturated straight-chain or branched hydrocarbon radical attached via any of the carbon atoms having 1 to n carbon atoms, for example, any one of the radicals methyl, ethyl, n-propyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2, 2-dimethylpropyl, 1-ethylpropyl, n-hexyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, or 1-ethyl-2-methylpropyl. The term “C2-Cn-alkenyl” as used herein refers to a straight or branched alkenyl chain moiety having from two to n carbon atoms and one or two double bonds, for example, ethenyl, prop-l -enyl, but-2-enyl. The term “C2-Cn-alkynyl” as used herein refers to a straight or branched alkynyl chain moiety having from two to n carbon atoms and one triple bond, for example, ethynyl, prop-2-ynyl, but-3-ynyl, The term “Cs-Cn-cycloalkyl” as used herein refers to 3-n membered cycloalkyl radical such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term "Ci-Cn-alkoxy" as used herein refers to a straight-chain or branched saturated alkyl radical having 1 to n carbon atoms (as mentioned above) which is attached via an oxygen atom, i.e., for example, any one of the radicals methoxy, ethoxy, n-propoxy, 1-methylethoxy, n-butoxy, 1-methylpropoxy, 2-methylpropoxy and 1,1-dimethylethoxy. The term “C2-Cn-alkenyloxy” as used herein refers to a straightchain or branched alkenyl chain having 1 to n carbon atoms (as mentioned above) which is attached via an oxygen atom. The term “Ci-Cn-alkoxy-Ci-Cn-alkyl” as used herein refers to an alkyl radical (as mentioned above) substituted with a Ci-Cn-alkoxy group. Examples are methoxymethyl, methoxyethyl, ethoxymethyl and propoxymethyl. The term “C3-Cn-cycloalkyl-Ci-Cn-alkyl” as used herein refers to an alkyl radical (as mentioned above) substituted with a Cs-Cn-cycloalkyl group. Examples are cyclopropylmethyl, cyclopropylethyl. Similarly, the term “C3-Cn-halocycloalkyl-Ci-Cn-alkyl” refers to an alkyl radical substituted with cycloalkyl group, wherein the cycloalkyl group is substituted by one or more of the same or different halogen atoms. Examples are 3,3-difluorobutylmethyl, and 1-chlorocyclopropylmethyl. The term “heterocycloalkyl” or “heterocyclyl” as used herein refers to a stable 3-, 4-, 5- or 6-membered non-aromatic monocyclic ring radical which comprises 1,2, or 3 heteroatoms / groups individually selected from nitrogen, oxygen, sulfur, S=O and SO2. The heterocyclyl radical may be bonded to the rest of the molecule via a carbon atom or heteroatom. Examples of heterocyclyl include, but are not limited to, epoxide, aziridinyl, pyrrolinyl, pyrrolidyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydrothiopyranyl, piperidyl, piperazinyl, tetrahydropyranyl, dioxolanyl, morpholinyl, oxazinanyl, oxetanyl, 1,1-dioxothietan-3-yl, or 6-lactamyl. The heterocycloalkyl radical may be substituted on the heteroatom and / or carbon atom. The term “cyanoheterocycloalkyl” refers to carbon atom on the heterocycloalkyl radical being substituted by a cyano group. The term “heterocycloalkyl-C3-Cn-cycloalkyl” as used herein refers to a cycloalkyl radical (as mentioned above) substituted with a heterocycloalkyl group. The heterocycloalkyl-C3-Cn-cycloalkyl group may be substituted on the heterocycloalkyl group and / or cycloalkyl group. Examples are 1-(tetrahydro-3-furanyl)cyclopropyl, 1-(tetrahydro-2-furanyl)cyclopropyl, 1-(tetrahydro-3-thienyl)cyclopropyl, 1-(3-pyrrolidinyl)cyclopropyl, 1 -(tetrahydro-2H-pyran-4-yl)cyclopropyl, 1 -(tetrahydro-3-furanyl)cyclobutanyl, 1 -and (Tetrahydro-3-furanyl)cyclopentanyl. The term “heterocycloalkyl-Ci-Cn-alkyl” as used herein refers to an alkyl radical (as mentioned above) substituted with a heterocycloalkyl group. The heterocycloalkyl-Ci-Cn-alkyl radical may be substituted on the heterocycloalkyl group and / or alkyl group. Examples are (tetrahydrofuran-3-yl)methanyl (or (tetrahydrofuran-3-yl)methyl), 1,3-dioxolane-2-methanyl (or 1,3-dioxolane-2-methyl), 2-pyrrolidinemethanyl (or 2-pyrrolidinemethyl), and a-methyl-2-pyrrolidinemethanyl (or a-methyl-2-pyrrolidinemethyl),. The term “cyano-Ci-Cn-alkyl” as used herein refers to Ci-Cn-alkyl radical having 1 to n carbon atoms (as mentioned above), where one of the hydrogen atoms in the radical is be replaced by a cyano group: for example, cyano-methyl, 2-cyano-ethyl, 2-cyano-propyl, 3-cyano-propyl, 1-(cyano-methyl)-2-ethyl, 1-(methyl)-2-cyano-ethyl, 4-cyanobutyl, and the like. Similarly, the term “cyano-Cs-Cn-cycloalkyl” refers to a Cs-Cn-cycloalkyl radical substituted with one of the hydrogen atoms by a cyano group; and the term term “cyano-C3-Cn-cycloalkyl-Ci-Cn-alkyl” refers to an Ci-Cn-alkyl radical having a cyano-Cs-Cn-cycloalkyl group. Halogen is generally fluorine, chlorine, bromine or iodine. This also applies, correspondingly, to halogen in combination with other meanings, such as haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy, and halocycloalkyl. The term "Ci-Cn-haloalkyl" as used herein refers to a straight-chain or branched saturated alkyl radical attached via any of the carbon atoms having 1 to n carbon atoms (as mentioned above), where some or all of the hydrogen atoms in these radicals may be replaced by fluorine, chlorine, bromine and / or iodine, i.e., for example, any one of chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3- pentafluoropropyl, heptafluoropropyl, 1 -(fluoromethyl)-2-fluoroethyl, 1 -(chloromethyl)-2-chloroethyl, 1 -(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl or nonafluorobutyl. According a term "Ci-C2fluoroalkyl" would refer to a Ci-C2alkyl radical which carries 1,2,3, 4, or 5 fluorine atoms, for example, any one of difluoromethyl, trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl or pentafluoroethyl. Similarly, the term “C2-Cn-haloalkenyl” or “C2-Cn-haloalkynyl” as used herein refers to a C2-Cn-alkenyl or C2-Cn-alkynyl radical respectively substituted with one or more halo atoms which may be the same or different. Similarly, the term “Cs-Cn-halocycloalkyl” or “Ci-Cn-haloalkoxy” as used herein refers to a Cs-Cn-cycloalkyl radical or Ci-Cn-alkoxyl radical respectively substituted with one or more halo atoms which may be the same or different. The term “hydroxy-Cs-Cn-cycloalkyl” or “carbamoyl-Cs-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a hydroxy (OH) group or a carbamoyl (NHC(=O)) group. The term “Ci-Cn-alkyl-carbonyloxy-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by RaC(=O)O- moiety wherein Ra is a Ci-Cn-alkyl group. The term “carboxy-Cs-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by C(=O)(O)- moiety. The term “Ci-Cn-alkoxycarbonyl-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by RcC(=O)- moiety wherein Rc is the Ci-Cn-alkoxy group as defined above. The term “Ci-Cn-alkylsulfonyloxy-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by RaS(O)2O- moiety wherein Ra is a Ci-Cn-alkyl group. The term “Ci-Cn-alkoxy-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-alkoxy group as defined above, Similarly, the term “Ci-Cn-haloalkoxy-C3-Cn-cycloalkyl” or “C2-Cn-alkynyl-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-haloalkoxy group or a C2-Cn-alkynyl group respectively as defined above. The term “Ci-Cn-alkylthio“ or “Ci-Cn-alkylsulfanyl“ as used herein refers to a Ci-Cn-alkyl group linked through a sulfur atom. The term “Ci-Cn-haloalkylthio“ or “Ci-Cn-haloalkylsulfanyl“ as used herein refers to a Ci-Cnhaloalkyl group linked through a sulfur atom. The term “Ci-Cn-alkylsulfinyl“ as used herein refers to a Ci-Cnalkyl group linked through the sulfur atom of a sulfinyl (or S(=O)-) group. The term “Ci-Cn-alkylsulfonyl“ as used herein refers to a Ci-Cnalkyl group linked through the sulfur atom of a sulfonyl (or S(=O)2-) group. The term “Ci-Cn-alkylsulfonyl-Ci-Cn-alkyl” as used herein refers to an a Ci-Cnalkyl radical substituted with a Ci-Cnalkylsulfonyl group. The term “Ci-Cn-alkylthio-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-akylthio (or RaS-) moiety wherein Ra is a Ci-Cn-alkyl group. Similarly, the term “Ci-Cn-alkylsulfinyl-Cs-Cn-cycloalkyl” or “Ci-Cn-alkylsulfonyl-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-akylsulfinyl (or RaS(O)-) or Ci-Cn-akylsulfonyl (or RaS(O)2-) moiety respectively wherein Ra is a Ci-Cn-alkyl group. The term “Ci-Cn-haloalkylthio-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-haloakylthio (or RbS-) moiety wherein Rb is a Ci-Cn-haloalkyl group. Similarly, the term “Ci-Cn-haloalkylsulfinyl-C3-Cn-cycloalkyl” or “Ci-Cn-haloalkylsulfonyl-C3-Cn-cycloalkyl” as used herein refers to a 3-n membered cycloalkyl radical substituted by a Ci-Cn-haloakylsulfinyl (or RbS(O)-) or Ci-Cn-haloakylsulfonyl (or RbS(O)2-) moiety respectively, wherein Rb is Ci-Cn-haloalkyl group. The term “Ci-Cn-haloalkylsulfonylamino” as used herein refers to a Ci-Cn-haloakylsulfonyl (or RbS(O)2-) group (wherein Rb is the Ci-Cn-haloalkyl group as defined above) linked through the nitrogen atom of an amino (or N-H) group. The term “Ci-Cn-alkylcarbonyl” as used herein refers to a Ci-Cn-alkyl group linked through the carbon atom of a carbonyl (C=O) group. The term “Ci-Cn-alkoxycarbonyl” as used herein refers to a Ci-Cn-alkoxy moiety linked through a carbon atom of a carbonyl (or C=O) group. The term “Ci-Cn-alkoxycarbonyl-Ci-Ce-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a “Ci-Cn-alkoxycarbonyl group. The term “benzoyl” as used herein refers to a phenyl group linked through the carbon atom of a carbonyl (C=O) group. The term “Ci-Cn-haloalkoxycarbonyl” as used herein refers to a Ci-Cn-haloalkoxy group linked through the carbon atom of a carbonyl (C=O) group. The term “C2-Cn-alkenyloxycarbonyl” as used herein refers to a C2-Cn-alkenyloxycarbonyl group linked through the carbon atom of a carbonyl (C=O) group. The term “Ci-Cn-alkylaminocarbonyl” as used herein refers to a Ci-Cn-alkylamino group (or RaNHC(=O)-, wherein Ra is a Ci-Cn-alkyl group) linked through the carbon atom of a carbonyl (C=O) group. The term “aminocarbonyl-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a aminocarbonyl (or NH2C(=O)-) group. The term “Ci-Cn-alkylaminocarbonyl-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Ci-Cn-alkylaminocarbonyl (or RaNHC(=O)-) group, wherein Ra is a Ci-Cn-alkyl group. The Ci-Cn-alkyl group linked to the nitrogen may be substituted. The term “C3-Cn-cycloalkylaminocarbonyl-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Cs-Cn-cycloalkylaminocarbonyl (or RdNHC(=O)-) group, wherein Rd is a Cs-Cn-cycloalkyl group. The Cs-Cn-cycloalkyl group linked to the nitrogen may be substituted. The term “Ci-Cn-haloalkylaminocarbonyl-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Ci-Cn-haloalkylaminocarbonyl (or RbNHC(=O)-) group, wherein Rb is a Ci-Cn-haloalkyl group. The Ci-Cn-haloalkyl group linked to the nitrogen may be substituted. The term “Ci-Cn-haloalkylcarbonyl-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Ci-Cn-haloalkylcarbonyl (or RbC(=O)-) group, wherein Rb is a Ci-Cn-haloalkyl group. The term “Ci-Cn-alkylcarbonyloxy-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Ci-Cn-alkylcarbonyloxy (or RaC(=O)O-) group, wherein Ra is a Ci-Cn-haloalkyl group. The term “Ci-Cn-alkoxycarbonyloxy-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a Ci-Cn-alkoxycarbonyloxy (or RcC(=O)O-) group, wherein Rc is a Ci-Cn-alkoxy group. The Ci-Cn-alkoxy group linked to the nitrogen may be substituted. The term “Ci-Cn-alkylaminocarbonyl-C3-Cn-cycloalkyl” as used herein refers to a Cs-Cn-cycloalkyl radical substituted by a Ci-Cn-alkylaminocarbonyl (or RaNHC(=O)- group, wherein Ra is a Ci-Cn-alkyl group). The Ci-Cn-alkylaminocarbonyl-C3-Cn-cycloalkyl radical may be substituted on alkyl group and / or cycloalkyl group. The term “C4-Cn-bicycloalkyl” as used herein refers to is an annulated non-aromatic bicyclic ring system comprising two rings fused together (i.e., sharing two carbon atoms), and consisting solely of carbon and hydrogen atoms. Examples are bicyclo[3.1,0]hexan-6-yl, bicyclo[4.1,0]heptan-7-yl, bicyclo[3.2.0]heptan-6-yl, bicyclo[3.2.0]heptan-3-yl, octahydro-2-pentalenyl, octahydro-1-pentalenyl. The term “Ci-Cn-alkoxyimino” as used herein refers to an a Ci-Cn-alkoxy group linked through the nitrogen atom of an imino (N=) moiety. The term “hydroxyimino” as used herein refers to an a hydroxy group linked through the nitrogen atom of an imino (N=) moiety. The term “hydroxyamino-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by a hydroxyamino (or (OH)NH-) moety. The term “Ci-Cn-alkoxyimino-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by Ci-Cn-alkoxyimino moety. The term “Ci-Cn-haloalkoxyimino-Ci-Cn-alkyl” as used herein refers to a Ci-Cn-alkyl radical substituted by Ci-Cn-alkoxyimino moety, wherein the Ci-Cn-alkoxy group is substituted by one or more same of different halogen atoms. The term "phenyl-Ci-Cn-alkyl" refers to a Ci-Cn-alkyl radical substituted by a phenyl ring. Examples include benzyl. The phenyl-Ci-Cn-alkyl radical may be substituted on alkyl group and / or phenyl group. The term “heteroaryl" refers to a 5- or 6-membered aromatic monocyclic ring radical which comprises 1,2, 3 or 4 heteroatoms individually selected from N, O and S. Examples of heteroaryl include, but are not limited to, furanyl, pyrrolyl, thienyl, pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, pyrazinyl, pyridazinyl, pyrimidyl or pyridyl. The term “heteroaryl-Ci-Cn-alkyl” or “heteroaryl-Cs-Cn-cycloalkyl” refers to an Ci-Cn-alkyl or Cs-Cn-cycloalkyl radical respectively substituted by a heteroaryl group. The heteroaryl-Ci-Cn-alkyl or heteroaryl-Cs-Cn-cycloalkyl radical may be substituted on heteroaryl, alkyl and / or cycloalkyl group as appropriate. The term “sulfamoyl” as used herein refers to an amino (NH2) moiety linked through the sulfur atom of an sulfonyl (SO2) moiety. The term “Ci-Cn-alkylaminosulfonyl” as used herein refers to a Ci-Cn-alkylamino (or RaNHC(=O)-) moiety, wherein Ra is a Ci-Cn-alkyl group) linked through the sulfur atom of an sulfonyl (SO2) moiety. As used herein, the term “may be substituted” means that substituents may or may not carry one or more identical or different substituents, e.g., one, two or three Rx substituents. For example, Ci-Cealkyl substituted by 1,2 or 3 halogens, may include, but not be limited to, -CH2CI, -CHCI2, -CCh, -CH2F, -CHF2, -CF3, -CH2CF3 or -CF2CH3 groups. As another example, Ci-Cealkoxy substituted by 1, 2 or 3 halogens, may include, but not be limited to, CH2CIO-, CHCI2O-, CCI3O-, CH2FO-, CHF2O-, CF3O-, CF3CH2O- or CH3CF2O- groups. The term “may be substituted” can be used interchangeably ith the term “unsubstituted or substituted”. As used herein, the term "controlling" refers to reducing the number of pests, eliminating pests and / or preventing further pest damage such that damage to a plant or to a plant derived product is reduced. As used herein, the term "pest" refers to insects, and molluscs that are found in agriculture, horticulture, forestry, the storage of products of vegetable origin (such as fruit, grain and timber); and those pests associated with the damage of man-made structures. The term pest encompasses all stages in the life cycle of the pest. As used herein, the term "effective amount" refers to the amount of the compound, or a salt thereof, which, upon single or multiple applications provides the desired effect. As used herein, the term “room temperature” or “RT” or “rt” refer to a temperature of about 15°C to about 35°C. For example, rt can refer to a temperature of about 20°C to about 30°C, rt can refer to a temperature of about 25°C. An effective amount is readily determined by the skilled person in the art, by the use of known techniques and by observing results obtained under analogous circumstances. In determining the effective amount a number of factors are considered including, but not limited to: the type of plant or derived product to be applied; the pest to be controlled & its lifecycle; the particular compound applied; the type of application; and other relevant circumstances. In one embodiment of the invention, compound of formula (I) wherein: A is O, or S; X is N, orCR8; Y is N or CR8; Z is N or CR8; provided at least one of X, Y, Z is N; R1 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-Ce-haloalkynyl, Ci-Ce-alkoxy, Ci-Ce-haloalkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, Cs-Ce-cycloalkyl-Ci-Ce-alkyl, C3-C6-halocycloalkyl-Ci-C6-alkyl, cyano-Ci-Ce-alkyl, cyano-Cs-Ce-cycloalkyl, cyano-C3-C6-cycloalkyl-Ci-C6-alkyl, cyano-heterocycloalkyl, hydroxy-Cs-Ce-cycloalkyl, Ci-Ce-alkyl-carbonyloxy-Cs-Ce-cycloalkyl, Ci-Ce-alkylsulfonyloxy-Cs-Ce-cycloalkyl, Ci-Ce-alkoxy-Cs-Ce-cycloalkyl, C1-Ce-haloalkoxy-Cs-Ce-cycloalkyl, Ci-C6-alkylthio-C3-C6-cycloalkyl, Ci-Ce-haloalkylthio-Cs-Ce-cycloalkyl, C1-Ce-alkylsulfinyl-Cs-Ce-cycloalkyl, Ci-Ce-haloalkylsulfinyl-Cs-Ce-cycloalkyl, Ci-C6-alkylsulfonyl-C3-C6-cycloalkyl, Ci-Ce-haloalkylsulfonyl-Cs-Ce-cycloalkyl, C2-C6-alkynyl-C3-C6-cycloalkyl, Ci-Ce-alkoxycarbonyl-Cs-Ce-cycloalkyl, carboxy-C3-C6-cycloalkyl, carbamoyl-C3-C6-cycloalkyl, Ci-C6-alkylaminocarbonyl-C3-C6-cycloalkyl (which may be mono- or poly-substituted by R8), C4-C8-bicycloalkyl, Ci-C6-alkoxyimino, phenyl (which may be mono- or poly-substituted by R10), phenyl-Ci-Cs-alkyl (the phenyl may be mono- or polysubstituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-Ci-Cs-alkyl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-C3-C6-cycloalkyl (the heteroaryl may be mono- or poly-substituted by R10), heterocycloalkyl (which may be substituted by R8), heterocycloalkyl-Ci-Ce-alkyl (which may be substituted by R8), or heterocycloalkyl-Cs-Ce-cycloalkyl (the heterocycloalkyl may be substituted by R8); R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-Ce-haloalkynyl, Ci-Ce-alkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, C1-Cs-haloalkoxy, Cs-Cs-cycloalkyl-Ci-Cs-alkyl, Cs-Cs-halocycloalkyl-Ci-Cs-alkyl, phenyl (which may be mono-or poly-substituted by R10), phenyl-Ci-Cs-alkyl (the phenyl may be mono- or poly-substituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-Ci-Cs-alkyl (the heteroaryl may be mono-substituted or polysubstituted by R10), cyano, cyano-Ci-Ce-alkyl, cyano-C3-C6-cycloalkyl, hydroxy, formyl, Ci-Ce-alkylcarbonyl, Ci-Ce-alkoxycarbonyl, Cs-Ce-cycloalkylcarbonyl, benzoyl that is mono or polysubstituted by R10, Ci-Ce-haloalkoxycarbonyl, C2-C6-alkenyloxycarbonyl, carbamoyl, Ci-Ce-alkylaminocarbonyl (the amino group may be substituted by R8), Ci-Ce-alkoxycarbonyl Ci-Ce-alkylamino (the amino group may be substituted by R8), Ci-Ce-alkoxycarbonyl amino (the amino group may be substituted by R8), (Ci-C6-alkylthio)carbonyl, (Ci-C6-alkyl)thiocarbonyl, (Ci-C6-alkoxy)thiocarbonyl, thiocarbamoyl, Ci-C6-alkylamino-thiocarbonyl (the amino group may be substituted by R8), Ci-Ce-alkylsulfonyl, Ci-Ce-haloalkylsulphonyl, sulfamoyl, Ci-C6-alkylaminosulfonyl (the amino group may be substituted by R8), Ci-C6-alkoxycarbonyl-Ci-C6-alkyl, aminocarbonyl-Ci-C6-alkyl, Ci-Ce-alkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), C3-C6-cycloalkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), Ci-Ce-haloalkylaminocarbonyl-Ci-Ce-alkyl (the amino group may be substituted by R8), Ci-Ce-alkylcarbonyl-Ci-Ce-alkyl, Ci-C6-haloalkylcarbonyl-Ci-C6-alkyl, Ci-Ce-alkylcarbonyloxy-Ci-Cs-alkyl, Ci-Ce-alkoxycarbonyloxy-Ci-Ce-alkyl, Ci-Ce-alkoxycarbonylamino-Ci-Ce-alkyl (the amino group may be substituted by R8), hydroxyimino, hydroxyamino-Ci-C6-alkyl, Ci-C6-alkoxyimino, Ci-C6-alkoxyimino-Ci-C6-alkyl, or Ci-C6-haloalkoxyimino-Ci-C6-alkyl; R3 is halogen, cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, C3-C6-cycloalkyl, Ci-C6-haloalkyl, or Ci-Ce-haloalkoxy; R4 is Ci-Ce-alkyl that is mono- or polysubstituted by R5, or Cs-Ce-cycloalkyl that is mono- or polysubstituted by R5; R5 is independently selected from halogen, Ci-Ce-alkyl, Cs-Ce-cycloalkyl, Ci-Ce-alkoxy, Cs-Ce-cycloalkoxy, Ci-Ce-haloalkyl, Cs-Ce-halocycloalkyl, Ci-Ce-haloakoxy, Cs-Ce-halocycloalkoxy, Ci-Ce-alkylthio, Ci-Ce-haloalkylthio, Cs-Ce-cycloalkylthio, Ci-C6-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C6-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R8(the amino group may be substituted by R6); R6 is independently selected from Ci-Ce-alkyl, Ci-Ce-alkoxy, Ci-C6-alkoxy-Ci-C6-alkyl, cyano-Ci-Ce-alkyl, Ci-Ce-haloalkyl, Cs-Ce-cycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Ce-alkylcarbonyl, and Ci-Ce-alkoxycarbonyl; R8 is independently selected from hydrogen, halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, and cyano; R9 is independently selected from halogen, Ci-C3-alkyl, Ci-C3-alkoxy, Ci-C3-haloalkyl, and cyano; and R10 is independently selected from halogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, C3-C6-halocycloalkyl-Ci-C6-alkyl, Ci-Ce-alkoxy, Ci-Ce-haloalkoxy, Ci-Ce-alkylthio, Ci-C6-haloalkylthio, Ci-C©-alkylsulfinyl, Ci-Ce-haloalkylsulfinyl, Ci-Ce-alkylsulfonyl, Ci-Ce-haloalkylsulphonyl, Ci-C6-alkylthio-Ci-C6-alkyl, Ci-C6-haloalkylthio-Ci-C6-alkyl, Ci-Ce-alkylsulfonyloxy, Ci-Ce-haloalkylsulfonyloxy, phenyl (which may be mono- or poly-substituted independently selected from halogen, Ci-Ce-alkyl and Ci-Ce-haloalkyl), phenyl-Ci-Cs-alkyl, phenyl-Ci-Cs-alkoxy, cyano, and nitro; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer and N-oxide of the compound of formula (I). In an embodiment, a compound of formula (I) is represented by the formula (1-1), (I-2), (I-3), or (I-4), where A, R1, R2, R3 and R4 are as defined in the first aspect. In an embodiment, a compound of formula (I) is represented by the formula (1-1 a), (l-2a), (l-3a), or (l-4a), where R1, R2, R3 and R6 are as defined in the first aspect; and R7 is, independent of (1-1 a), (l-2a), (l-3a), and (l-4a), selected from Ci-Ce-alkyl, Ci-Ce-haloalkyl, and C3-C6-cycloalkyl that may be mono or polysubstituted by R9, where the methyl group connected to the carbon designated by a star (*) can be can be in the form of (S) or the (R) enantiomer; or a mixture thereof. In an embodiment, the compound as represented by the formulae (1-1 a), (l-2a), (l-3a), and (l-4a), is an (S) enantiomer. Embodiments according to the invention are provided as set out below. In an embodiment of each aspect of the invention, A is A. oxygen; or B. sulfur. In an embodiment of each aspect of the invention, A. one or two of X, Y and Z is N, and the rest CR8; or B. X is N, and Z and Y are each CR8; or C. X and Z are N, and Y is CR8; or D. X and Y are N, and Z is is CR8; or E. Y is N, and X and Z are each CR8; F. X is N, and Z and Y are each CH; or G. X and Z are N, and Y is CH; or H. X and Y are N, and Z is is CH; or I. Y is N, and X and Z are each CH. In an embodiment of each aspect of the invention, R1 is A. hydrogen, Ci-Ce-alkyl, Ci-C6-haloalkyl, C2-C6-alkynyl, C3-C6-cycloalkyl, cyano-C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, heterocyclyl, or Ci-C6-alkoxy-C3-C6-cycloalkyl; or B. hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, cyano-C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, 4- or 5-membered heterocyclyl, or Ci-C3-alkoxy-C3-C4-cycloalkyl; or C. Ci-Ce-alkyl, Ci-Ce-haloalkyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, Cs-Ce-cycloalkyl-Ci-Ce-alkyl, 4-membered heterocyclyl, or cyano-Cs-Ce-cycloalkyl; or D. Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl having a SO2, or cyano-C3-C4-cycloalkyl; or E. ethyl, isopropyl, propargyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, cyclopropyl, 1-cyanocyclopropyl, 1-cyanocyclobutyl, 3,3-difluorocyclobutyl, 1,1-dioxothietan-3-yl, or cyclopropylmethyl. In an embodiment of each aspect of the invention, R2 is A. hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, Cs-Ce-cycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Ce-alkoxy-Cs-Ce-cycloalkyl, Ci-C6-alkoxy-Ci-C6-alkyl, or Ci-Ce-alkylcarbonyl; or B. hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C3-C4-cycloalkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, Ci-Cs-alkoxy-C3-C4-cycloalkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, or Ci-Cs-alkylcarbonyl; or C. hydrogen, Ci-Ce-alkyl, Ci-Ce-alkylcarbonyl, or Ci-Ce-alkoxycarbonyl; or D. hydrogen, Ci-Cs-alkyl, Ci-Cs-alkylcarbonyl, or Ci-Cs-alkoxycarbonyl; or E. hydrogen, methyl, acetyl or2-methyl propanoyl. In an embodiment of each aspect of the invention, R3 is A. halogen, Ci-Ce-alkyl, or cyano; or B. halogen, Ci-Cs-alkyl, or cyano; or C. chlorine, methyl, or cyano; or D. chlorine or bromine; or E. chlorine. In an embodiment of each aspect of the invention, R4 is In an embodiment of each aspect of the invention, R5 is A. Ci-C6-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C6-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); or B. Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), or C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); or C. isopropylsulfonylamino,          difluoromethylsulfonylamino,          trifluoromethylsulfonylamino, difluoromethylsulfonylamino, dichloromethylsulfonylamino, or cyclopropylsulfonylamino; or D. isopropylsulfonylamino,          difluoromethylsulfonylamino,          trifluoromethylsulfonylamino, difluoromethylsulfonylamino, or cyclopropylsulfonylamino; or E. difluromethylsulfonylamino, or trifluoromethylsulfonylamino. In an embodiment of each aspect of the invention, R6 is A. hydrogen, Ci-Ce-alkyl, Ci-C6-alkoxy-Ci-C6-alkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, or Ci-Ce-alkylcarbonyl; or B. hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; or C. hydrogen, methyl, meth oxy methyl, cyclopropylmethyl, or acetyl. In an embodiment of each aspect of the invention, R7 is A. Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9, or B. methyl, ethyl, iso-propyl, trifluoromethyl, difluoromethyl, or cyclopropyl; or C. methyl, ethyl, iso-propyl, trifluoromethyl, difluoromethyl, dichloromethyl, or cyclopropyl; or D. iso-propyl, trifluoromethyl, difluoromethyl, or cyclopropyl. In an embodiment of each aspect of the invention, R8 is A. hydrogen, halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano; or B. hydrogen, chloro, bromo, fluoro, methyl, ethyl, iso-propyl, methoxy, trifluoromethyl, diifluoromethyl, 2,2,2-trifluoroethyl, or cyano; or C. hydrogen. In an embodiment of each aspect of the invention, R9 is A. halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano; or B. chloro, bromo, fluoro, methyl, ethyl, iso-propyl, methoxy, trifluoromethyl, diifluoromethyl, 2,2,2-trifluoroethyl, or cyano. In an embodiment of each aspect of the invention, R10 is A. halogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, C3-C4-halocycloalkyl-Ci-C3-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkoxy, Ci-Cs-alkylthio, C1-C3-haloalkylthio, Ci-C3-alkylsulfinyl, Ci-C3-haloalkylsulfinyl, Ci-C3-alkylsulfonyl, Ci-C3-haloalkylsulphonyl, Ci-C3-alkylthio-Ci-C3-alkyl, Ci-Cs-haloalkylthio-Ci-Cs-alkyl, Ci-C3-alkylsulfonyloxy, C1-C3- haloalkylsulfonyloxy, phenyl (which may be mono- or poly-substituted independently selected from halogen, Ci-Ce-alkyl and Ci-Ce-haloalkyl), phenyl-Ci-Cs-alkyl, phenyl-Ci-Cs-alkoxy, cyano, or nitro; or B. chloro, bromo, fluoro, methyl, ethyl, iso-propyl, methoxy, trifluoromethyl, diifluoromethyl, 2,2,2-trifluoroethyl, or cyano. The present invention, accordingly, makes available a compound of formula (I) having A, X, Y, Z, R1, R2, R3, R4, R5, R6, R8, R9, and R10 as defined above in all combinations I each permutation. Accordingly, made available, for example, is a compound of formula (I) with A being embodiment A (i.e A is oxygen); X, Y and Z being embodiment A (i.e one or two ofX, Y and Z is N, and the rest CR8); R1 being embodiment B (i.e. R1 is hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, cyano-Cs-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, 4- or 5-membered heterocyclyl, orCi-Cs-alkoxy-C3-C4-cycloalkyl); R2 being embodiment C (i.e. R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-alkylcarbonyl, or Ci-Ce-alkoxycarbonyl); R3 being embodiment B (i.e. R3is halogen, Ci-Cs-alkyl, or cyano); R4 being of the first aspect (i.e. R4 is Ci-Ce-alkyl that is mono- or polysubstituted by R5, or Cs-Ce-cycloalkyl that is mono-or polysubstituted by R5); R5 being embodiment B (i.e. R5 is Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 being embodiment B (i.e. R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl); and R9 being of the first aspect (i.e. R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano). Preferably a compound of formula (I) wherein A being embodiment A (i.e A is oxygen); X, Y and Z being embodiment A (i.e one or two ofX, Y and Z is N, and the rest CR8); R1 being embodiment B (i.e. R1 is hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, cyano-C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, 4- or 5-membered heterocyclyl, or Ci-C3-alkoxy-C3-C4-cycloalkyl); R2 being embodiment C (i.e. R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-alkylcarbonyl, or Ci-Ce-alkoxycarbonyl); R3 being embodiment B (i.e. R3is halogen, Ci-Cs-alkyl, or cyano); R5 being embodiment C (i.e. R5 is Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 being embodiment B (i.e. R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl); and R9 being of the first aspect (i.e. R9 is (i.e. R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano). -15 In an embodiment of each aspect of the invention, the compound of the formula (1-1), (I-2), (I-3), or (I-4) wherein R1 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C2-C6-alkynyl, C3-C6-cycloalkyl, cyano-Cs-Ce-cycloalkyl, C3-Ce-halocycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, heterocyclyl, or Ci-C6-alkoxy-C3-C6-cycloalkyl; R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Ce-alkoxy-Cs-Ce-cycloalkyl, Ci-C6-alkoxy-Ci-C6-alkyl, or Ci-Ce-alkylcarbon; R3 is halogen, Ci-Ce-alkyl, or cyano; R5is Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. In an embodiment of each aspect of the invention, the compound of the formula (1-1), (I-2), (I-3), or (I-4) wherein R1 is Ci-Ce-alkyl, Ci-Ce-haloalkyl, C2-Ce-alkynyl, Cs-Ce-cycloalkyl, Cs-Ce-halocycloalkyl, Cs-Ce-cycloalkyl-Ci-Ce-alkyl, 4-membered heterocyclyl, or cyano-Cs-Ce-cycloalkyl; R2 is hydrogen, Ci-Ce-alkyl, Ci-Ce-alkylcarbonyl, or Ci-Ce-alkoxycarbonyl; R3 is halogen, Ci-Cs-alkyl, or cyano; R5is Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 is hydrogen, Ci-Cs-alkyl, Ci-Ce-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C4-alkyl, or Ci-Cs-alkylcarbonyl; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. In an embodiment of each aspect of the invention, the compound of the formula (1-1), (I-2), (I-3), or (I-4) wherein R1 is ethyl, isopropyl, propargyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, cyclopropyl, 1-cyanocyclopropyl, 1-cyanocyclobutyl, 3,3-difluorocyclobutyl, 1,1-dioxothietan-3-yl, or cyclopropylmethyl; R2 is hydrogen, methyl, acetyl or2-methyl propanoyl; R3 is chlorine, methyl, or cyano; R5 is Ci-Cs-alkylsulfonylamino (the amino group may be substituted by R6), Ci-Cs-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 is hydrogen, methyl, methoxymethyl, cyclopropylmethyl, or acetyl; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. In an embodiment of each aspect of the invention, the compound of the formula (1-1), (I-2), (I-3) or (I-4) wherein R1 is ethyl, isopropyl, propargyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, cyclopropyl, 1-cyanocyclopropyl, 1-cyanocyclobutyl, 3,3-difluorocyclobutyl, 1,1-dioxothietan-3-yl, or cyclopropylmethyl; R2 is hydrogen, methyl, acetyl or2-methyl propanoyl; R3 is chlorine, bromine or methyl; R5 is Ci-C3-alkylsulfonylamino (the amino group may be substituted by R6), Ci-C3-haloalkylsulfonylamino (the amino group may be substituted by R6), and C3-C6-cycloalkylsulfonylamino that may be mono or polysubstituted by R9 (the amino group may be substituted by R6); R6 is hydrogen, methyl, meth oxy methyl, cyclopropylmethyl, or acetyl; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. In an embodiment of each aspect of the invention, the compound of the formula (l-1a), (l-2a), (l-3a) or (I-4a) has as R1 hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C6-alkynyl, C3-C6-cycloalkyl, cyano-Cs-Ce-cycloalkyl, C3-C6-halocycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Cs-alkyl, heterocyclyl, or Ci-Ce-alkoxy-Cs-Ce-cycloalkyl; as R2 hydrogen, Ci-Cs-alkyl, Ci-Cs-haloalkyl, Cs-Ce-cycloalkyl, C3-C6-cycloalkyl-Ci-C6-alkyl, Ci-Ce-alkoxy-Cs-Ce-cycloalkyl, Ci-C6-alkoxy-Ci-C6-alkyl, or Ci-Ce-alkylcarbon; as R3 halogen, Ci-Ce-alkyl, or cyano; as R6 hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, orCi-Cs-alkylcarbonyl; and as R7 Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9 (wherein R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano). In an embodiment of each aspect of the invention, the compound of the formula (l-1a), (l-2a), (l-3a) or (I-4a) has as R1 ethyl, isopropyl, propargyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, cyclopropyl, 1-cyanocyclopropyl, 1-cyanocyclobutyl, 3,3-difluorocyclobutyl, 1,1-dioxothietan-3-yl, or cyclopropylmethyl; as R2 hydrogen, methyl, acetyl or2-methyl propanoyl; as R3 chlorine, bromine or methyl; as R6 hydrogen, methyl, methoxymethyl, cyclopropylmethyl, or acetyl; and as R7 Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9 (wherein R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano). In an embodiment of each aspect of the invention, the compound of the formula (l-1a), (l-2a), (l-3a) or (I-4a) has as R1 ethyl, isopropyl, propargyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, cyclopropyl, 1- cyanocyclopropyl, 1-cyanocyclobutyl, 3,3-difluorocyclobutyl, 1,1-dioxothietan-3-yl, or cyclopropylmethyl; as R2 hydrogen, methyl, acetyl or2-methyl propanoyl; as R3 chlorine, bromine or methyl; as R6 hydrogen, methyl, methoxymethyl, cyclopropylmethyl, or acetyl; and as R7 Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9 (wherein R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano). In a further embodiment of the invention, the compound of formula (I) is a compound of formula (1-1), wherein A is O; R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R2 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkylcarbonyl, or Ci-Cs-alkoxycarbonyl; R3 is halogen; R5 is Ci-C3-alkylsulfonylamino, Ci-C3-haloalkylsulfonylamino, or C3-C6-cycloalkylsulfonylamino, wherein any of said amino-groups is unsubstituted or substituted by R6; and wherein any of said cycloalkyl-groups may be mono-or polysubstituted by R9; R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; and R9 is halogen, Ci-Cs-alkyl, Ci-C3-alkoxy, Ci-Cs-haloalkyl, or cyano. In a further embodiment of the invention, the compound of formula (I) is a compound of formula (1-1 a), wherein R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R2 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkylcarbonyl, or Ci-Cs-alkoxycarbonyl; R3 is halogen; R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. In a further embodiment of the invention, the compound of formula (I) is a compound of formula (1-1 a), (1-1 a) wherein R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R2 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkylcarbonyl, or Ci-Cs-alkoxycarbonyl; R3 is halogen; R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano, and wherein said compound is an (S) enantiomer. In a further embodiment of the invention, the compound of formula (I) is a compound of formula (1-1 a), (1-1 a) wherein R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R2 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkylcarbonyl, or Ci-Cs-alkoxycarbonyl; R3 is chlorine or bromine; R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano, and wherein said compound is an (S) enantiomer. In an embodiment, a compound of formula (I) is represented by the formula (l-5a), wherein X, Y, Z, R1, R2, R3 and R6 are as defined as for the compound of formula (I); and R7 is selected from Ci-Cs-alkyl, Ci-Ce-haloalkyl, or Cs-Ce-cycloalkyl that may be mono or polysubstituted by R9. Preferably, in a compound of formula (l-5a), X is N; Y, Z are CH; R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R3 is halogen; R6 is hydrogen, Ci-Cs-alkyl, Ci-Cs-alkoxy-Ci-Cs-alkyl, C3-C4-cycloalkyl-Ci-C3-alkyl, or Ci-Cs-alkylcarbonyl; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. Preferably, in a compound of formula (l-5a), X is N; Y, Z are CH; R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R3 is chlorine, bromine, or methyl; R6 is hydrogen; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl that may be mono or polysubstituted by R9; and R9 is halogen, Ci-Cs-alkyl, Ci-Cs-alkoxy, Ci-Cs-haloalkyl, or cyano. Preferably, in a compound of formula (l-5a), X is N; Y, Z are CH; R1 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, C2-C4-alkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C3-C4-cycloalkyl-Ci-Cs-alkyl, 4-membered heterocyclyl, or cyano-C3-C4-cycloalkyl; R3 is chlorine, bromine, or methyl; R6 is hydrogen; R7 is Ci-Cs-alkyl, Ci-Cs-haloalkyl, or C3-C4-cycloalkyl. In one embodiment of the invention, the compound of formula (I) according to the invention is selected from compounds listed in any one of Tables 1 to 5. In another embodiment of the invention the compound of formula (I) according to the invention is selected from compounds listed in Table P (below). Preferably the compound of formula (I) according to the invention is selected from 2-chloro-N-cyclopropyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(2,2,2-trifluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-(dichloromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(1-bicyclo[1.1,1]pentanyl)- 2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, tert-butyl N-[(1 S)-2-[[6-chloro-5-[(1 -cyanocyclopropyl)carbamoyl] -3-pyridyl]oxy]-1-methyl-ethyl]-N-(trifluoromethylsulfonyl)carbamate, 2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-[methyl(trifluoromethylsulfonyl) amino] propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-[cyanomethyl(trifluoromethylsulfonyl) amino] propoxy]pyridine-3-carboxamide, [[(1 S)-2-[[6-chloro-5- [(1 -cyanocyclopropyl)carbamoyl]-3-pyridyl]oxy]-1 -methyl-ethyl]- (trifluoromethylsulfonyl)amino] methyl 2-methylpropanoate, 2-chloro-N-cyclopropyl-5-[(2S)-2- (difluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-tert-butyl-2-chloro-5-[(2S)-2- (trifluoromethylsulfonylamino) p ro poxy] py rid ine-3-carboxamide, N-acetyl-2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy]pyridine-3-carboxamide, [[(1S)-2-[[6-chloro-5-(cyclopropylcarbamoyl) -3-pyridyl]oxy]-1-methyl-ethyl]-(trifluoromethylsulfonyl) amino] methyl 2-methylpropanoate, methyl N-[(1S)-2-[[6-chloro-5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-N-(trifluoromethylsulfonyl)carbamate, 2-chloro-5-[(2S)-2-[cyanomethyl (trifluoromethylsulfonyl)amino] propoxy]-N-cyclopropyl-pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-[methyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[2- (trifluoromethylsulfonylamino) ethoxy] pyridine-3-carboxamide, 2-chloro-N-(5-cyano-3-fluoro-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(5-chloro-3-fluoro-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(5-chloro-3-methyl-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy]-N-(2,4,6-trifluorophenyl) pyridine-3-carboxamide, 2-chloro-N-(4-cyano-2-fluoro-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(2,4-difluorophenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(2-fluoro-4-methylsulfonyl-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(4-chloro-2-fluoro-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(1-bicyclo[1.1,1]pentanyl)-2- methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-[1-[2-(5-cyano-2-pyridyl)-1,2,4-triazol-3-yl] ethyl]-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-[(5-chloro-2-pyridyl)methyl]- 2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-[(2E)-2-methoxyimino-1,1-dimethyl-ethyl] -2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-methyl-N-[3-oxo-2-(2,2,2-trifluoroethyl) isoxazolidin-4-yl]-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(1-cyclopropylethyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-[(3-chloro-2-pyridyl)methyl]- 2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3- carboxamide, N-(2,4-difluorophenyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-isopropyl-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-[1-(4-fluorophenyl)-2-oxo-pyrrolidin-3-yl] -2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-ethyl-2-methyl-5-[(2S)-2- (trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(3,3-difluorocyclobutyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-methyl-N-[1 -(5-methyl-1,2,4- oxadiazol-3-yl)ethyl]-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(2,2-difluoroethyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-cyclopropyl-N,2-dimethyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(cyclopropylmethoxy)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, tert-butyl N-[(1 S)-2-[[6-chloro- 5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1 -methyl-ethyl]-N- (trifluoromethylsulfonyl)carbamate, 5-[(2S)-2-[acetyl(trifluoromethylsulfonyl)amino] propoxy]-2-chloro-N-cyclopropyl- pyridine-3-carboxamide, N-benzyl-2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyclopropylethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-[(1-cyanocyclopropyl) methyl]-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl) -N- methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclobutyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-[(4S)-2-ethyl-3-oxo-isoxazolidin-4-yl] -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-ethyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(3-methyltetrahydrofuran-3-yl) -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-prop-2-ynyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-[2-(cyclopropylmethylamino) -2-oxo-ethyl]-5-[(2S)-2- (trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-[3-oxo-2-(2,2,2-trifluoroethyl) isoxazolidin-4-yl]-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(2,2-difluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-phenyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyano-1-methyl-ethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(2,2-difluoroethyl)-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(4-fluoro-2-methyl-phenyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, N-cyclopropyl-5-[(2S)-2-[methoxymethyl (trifluoromethylsulfonyl) amino] propoxy]-2-methyl-pyridine-3-carboxamide, N-cyclopropyl-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy]-N-(2,2,2-trifluoroethyl)pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethyl sulfonyl)amino] propoxy] pyridine-3-carboxamide, 2-chloro-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl] -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, N-(1-bicyclo[1.1.1]pentanyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(1-cyanocyclopropyl)-N,5-dimethyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(4-ethylthiazol-5-yl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(1,3-dihydroisobenzofuran-5-yl methyl)-5-methyl-2-[(2S)-2- (trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 5-methyl-N-[2-oxo-1-(2,2,2-trifluoroethyl) pyrrolidin-3-yl]-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-[2-(2-fluorophenoxy)ethyl]-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(5-methoxy-1,1-dimethyl-pent-2-ynyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(1-cyclopropylethyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-[1-(2-ethylthiazol-4-yl)ethyl]-5-methyl-2-[(2S)-2- (trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(3-cyano-2-fluoro-phenyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 5-methyl-N-[1-(3-pyridyl)ethyl]-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-benzyl-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl) amino] propoxy]-5-methyl-pyridine-4-carboxamide, N-(1 -cyanocyclopropyl)-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl) amino] propoxy]-5-methyl-pyridine-4-carboxamide, 5-methyl-N-(2,2,2-trifluoroethyl)-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 5-bromo-N-cyclopropyl-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-4-carboxamide, 5-bromo-N-(1-cyanocyclopropyl)-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-4-carboxamide, 5-bromo-N-cyclopropyl- 2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 5-bromo-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-4-carboxamide, 5-bromo-N-(2,2,2-trifluoroethyl)-2-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-4-carboxamide, 5-bromo-N-(1-cyanocyclopropyl)-2-[(2S)-2-(trifluoromethylsulfonyl amino) propoxy]pyridine-4-carboxamide, 5-chloro-N-cyclopropyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 3-chloro-N-cyclopropyl-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridazine-4-carboxamide, 3-chloro-N-(1-cyanocyclopropyl)-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridazine-4-carboxamide, or N-(1 -bicyclo[1.1.1]pentanyl)-3-chloro-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridazine-4-carboxamide. More preferably the compound of formula (I) according to the present invention is selected from 2-chloro-N-cyclopropyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, or 2-chloro-N-(2,2,2-trifluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide. In a second aspect, the present invention makes available a composition comprising a compound of formula (I) as defined in the first aspect, one or more auxiliaries and diluent, and optionally one more other active ingredient. In a third aspect, the present invention makes available a method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound as defined in the first aspect or a composition as defined in the second aspect. In a fourth aspect, the present invention makes available a method for the protection of plant propagation material from the attack by insects, acarines, nematodes or molluscs, which comprises treating the propagation material or the site, where the propagation material is planted, with an effective amount of a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect. In a fifth aspect, the present invention makes available a plant propagation material, such as a seed, comprising, or treated with or adhered thereto, a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect. The present invention in a further aspect provides a method of controlling parasites in or on an animal in need thereof comprising administering an effective amount of a compound of the first aspect. The present invention further provides a method of controlling ectoparasites on an animal in need thereof comprising administering an effective amount of a compound of formula (I) as defined om the first aspect. The present invention further provides a method for preventing and / or treating diseases transmitted by ectoparasites comprising administering an effective amount of a compound of formula (I) as defined in the first aspect, to an animal in need thereof. Compounds of formula (I) can be prepared by those skilled in the art following known methods. More specifically compounds of formula I, and intermediates therefor can be prepared as described below in the schemes and examples. Certain stereogenic centers have been left unspecified for the clarity and are not intended to limit the teaching of the schemes in any way. The compounds of formula (I) according to the invention, wherein R1, R2, R3, R4, X, Y, Z are as defined for formula (I) and A is oxygen, can be obtained by transformation of a compound of formula (II), wherein R3, R4, X, Y, Z are as defined for formula (I) with a compound of formula (III), wherein R1 and R2 are as defined for formula (I), via an intermediate acid chloride or activated acylating agent as described below. This is shown in Scheme 1 below: Scheme 1 o o (IV)                                                                            (I) As shown in Scheme 1, compound II, are activated to compounds of formula IV by methods known to those skilled in the art and described for example in Tetrahedron 2005, 61 (46), 10827-10852. For example, compounds of formula IV where G is halogen are formed by treatment of compounds of formula II with for example, oxalyl chloride or thionyl chloride in the presence of catalytic quantities of DMF in inert solvents such as methylene dichloride or THF at temperatures between 25 to 170°C preferably 25 to 80°C. Treatment of IV with compounds of formula III, wherein R1 and R2 are as defined in formula I, optionally in the presence of a base, e.g. triethylamine or pyridine leads to compounds of formula I. Alternatively, compounds of formula I can be prepared by treatment of compounds of formula II with dicyclohexyl carbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to give the activated species IV, wherein G is Gi or G2, in an inert solvent, e.g. pyridine, or THF optionally in the presence of a base, e.g. triethylamine, at temperatures between rt and 180°C. In addition, an acid of the formula II can also be activated by reaction with a coupling reagent such as propanephosphonic acid anhydride (T3P®) or O-(7-Aza-1-benzotriazolyl)-N,N,N’,N’-tetramethyluronium-hexafluorophosphat (HATU) to provide compounds of formula IV wherein G is G3 and G4 as described for example in Synthesis 2013, 45, 1569 and J. Prakt. Chemie 1998, 340, 581. Subsequent reaction with an amine of the formula III provides compounds of formula I. The compounds of formula (II), wherein R3, R4, X, Y, Z are as defined for formula (I), can be obtained by transformation of a compound of formula (V), wherein R3, R4, X, Y, Z are as defined for formula (I) and R20 is Ci-Cealkyl, in the presence of a base or an acid. This is shown in Scheme 2 below. Scheme 2 As shown in Scheme 2, compounds (V) can undergo a hydrolysis reaction under basic conditions to compounds (II) by methods known to those skilled in the art and described for example in ACS Chemical Neuroscience 2017, 2374. For example, the reaction can be performed in water or in organic solvent, such as methanol, THF or methylene dichloride, or in mixtures; in the presence of a base, such as lithium hydroxide, sodium hydroxide or potassium hydroxide. Alternatively, the conversion of compounds (V) into compounds (II) can be performed under acidic conditions by methods known to those skilled in the art and described for example in J. Med. Chem. 1986, 2363. For example, the reaction can be performed in water or in mixtures of water and an organic solvent, such as methanol, THF or dioxane; in the presence of an acid, such as trifluoroacetic acid, hydrochloric acid or sulfuric acid. The compounds of formula (Va), wherein R3, X, Y, Z are as defined for formula (I), and R20 is Ci-Ce alkyl, and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (VI), wherein R3, X, Y, Z are as defined for formula (I), and R20 is Ci-Ce alkyl, and R23 is hydrogen or methyl, in the presence of a sulfonylating agent of formula (VII), wherein R7 is Ci-Ce alkyl, Ci-Cehaloalkyl, Ci-Ce cycloalkyl orCi-Cehalocycloalkyl and G is an halogen or an activating group of formula G5. This is shown in Scheme 3 below. Scheme 3 As shown in Scheme 3, compounds (VI) can be converted to compounds (Va) by methods known to those skilled in the art and described for example in Angew. Chem. Int. Ed. 2016, 5299; J. Am. Chem. Soc. 2018, 5322; WO2021153720, WO2010150192. For example, the reaction can be performed in inert organic solvent, such as methylene dichloride, dioxane or THF, in the presence of a base, such as triethylamine, pyridine or 1,8-Diazabicyclo[5.4.0]undec-7-ene. Alternatively, as known to those skilled in the art, compound (VI) in a salt form (e.g. hydrochloric salt, hydrobromic salt, trifluoroacetic salt, paratoluensulfonic salt) can be similarly used in a conversion to compound (Va). The compounds of formula (VI), wherein R3, X, Y, Z are as defined for formula (I), and R20 is Ci-Ce alkyl, and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (VIII), wherein R3, X, Y, Z are as defined for formula (I), R20 and R21 are Ci-Ce alkyl, and R23 is hydrogen or methyl. This is shown in Scheme 4 below. Scheme 4 As shown in Scheme 4, compounds (VIII) can be converted to compounds (VI) by methods known to those skilled in the art and described for example in WO2002059117, J. Med. Chem. 2003, 5238, Org. Lett. 2022, 2064. For example, the reaction can be performed in organic solvent, such as methylene dichloride, dioxane or THF, in the presence of an organic or inorganic acid, such as hydrochloric acid, trifluoroacetic acid or paratoluensulfonic acid. Compounds (VI) can also be obtained and used in following transformations in their salt form (e.g. hydrochloric salt, hydrobromic salt, trifluoroacetic salt, paratoluensulfonic salt). The compounds of formula (VIII), wherein R3, X, Y, Z are as defined for formula (I), R20 and R21 are Ci-Ce alkyl, and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (IX), wherein R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Ce alkyl and R23 is hydrogen or methyl, with an alkylating agent of formula (Xa), wherein R21 is Ci-Ce alkyl and Q is halogen, hydroxyl of sulfonate group. This is shown in Scheme 5 below. Scheme 5 Q = halogen, Q1        Q2 Q3 (Xb) As shown in Scheme 5, compounds (IX) can be converted by an alkylative reaction with Xa (when Q is i.e. halogen or sulfonate Q1 or Q2) to compounds (VIII) by methods known to those skilled in the art and described for example in Angew. Chem. Int. Ed. 2017, 12518; WO2012101244, WO2004050619, WO2007072041. For example, the reaction can be performed in organic solvent, such as dimethylformamide, acetone or acetonitrile in the presence of a base, such as cesium carbonate, sodium hydride or sodium carbonate. Alternatively, compounds (IX) can be converted by a Mitsunobu reaction with Xa (when Q is equal to OH) by methods known to those skilled in the art and described for example in WO2012074126; Bioorg. Med. Chem. Left1992, 481, Beilstein J. Org. Chem.2006, 2, 21. For example the reaction can be performed in organic solvent, such as toluene or THF in the presence of an azadicarboxylate reagent, such as diethyl azadicarboxylate or diisopropyl azadicarboxylate, and a phospine reagent, such as triphenyl phosphine. Alterantively, compounds (IX) can be converted by an alkylative reaction with aziridine Xb to compounds (VIII) by methods known to those skilled in the art and described for example in WO2007070201. For example the reaction can be performed in organic solvent, such as acetonitrile in the presence of a base, such as potassium carbonate, sodium hydride or sodium carbonate. Compounds of formula (IX), wherein R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Ce alkyl, can be obtained in two steps by transformation of a compound of formula (XTl), wherein R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Ce alkyl and R22 is halogen via and intermediate compound of formula (XI), wherein R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Ce alkyl. This is shown in Scheme 6 below. Scheme 6 (IX) As shown in Scheme 6, compounds (XII) can be converted to compounds (XII) by methods known to those skilled in the art with the name of Miyaura borylation reaction and described for example in J. Org. Chem., 1995, 7508; J. Org. Chem., 2021, 103. For example, the reaction can be performed in organic solvent, such as THF or dioxane, in the presence of a base, such as potassium carbonate or potassium acetate and  a palladium catalyst in combination with an  appropriate ligand, such  as 1,T- bis(diphenylphosphino)ferrocene dichloropalladium. Intermediate (XI) can be converted into compounds of formula (IX) by methods known to those skilled in the art and described for example in Tetrahedron Letters 2014, 2082; Tetrahedron Lett. 2017, 3323; Tetrahedron 2005, 1417. For example the reaction can be performed in mixtures of water and an organic solvent, such as ethanol, acetonitrile or methylene dichloride, in the presence of hydrogen peroxide. Alternatively, compounds of formula (VIII), wherein R3, X, Y, Z are as defined for formula (I), R20 and R21 are Ci-Ce alkyl, and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XII), wherein R3, X, Y, Z are as defined for formula (I), R20 is Ci-Ce alkyl, R22 is a halogen and R23 is hydrogen or methyl, with a compound of formula (Xa), wherein R21 is Ci-Ce alkyl and Q is hydroxy. This is shown in Scheme 7 below. Scheme 7 (XII)                                                                                                     (VIII) As shown in Scheme 7, compounds (XII) can be converted to compounds (VIII) by methods known to those skilled in the art and described for example in Tetrahedron 1988, 91; J. Am. Chem. Soc. 2010, 11592, WO2020211836. For example, the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction as shown in WO2017147700 and in J. Med. Chem. 2021, 11570. Compounds of formula (la), wherein R1, R2, R3, R6, R7, X, Y and Z are as defined for formula (I), and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (lb), R1, R2, R3, R7, X, Y and Z are as defined for formula (I) and R23 is hydrogen or methyl, with a compound of formula (Xlla), wherein R6 is as defined for formula (I) and Q is halogen or sulfonate. This is shown in Scheme 8 below. Scheme 8 As shown in Scheme 8, compounds (lb) can be converted to compounds (la) by methods known to those skilled in the art and described for example in ACS Combinatorial Science 2016, 569; WO202115372. For example, the reaction can be performed in organic solvent, such as methylene dichloride, dimethylformamide or acetonitrile, in the presence of a base, such as potassium carbonate or triethylamine. Compounds of formula (Id), wherein R1, R2, R3, R4, X, Y and Z are as defined for formula (I), can be obtained by transformation of a compound of formula (Ic), R1, R2, R3, R4, X, Y and Z are as defined for formula (I). This is shown in Scheme 9 below. As shown in Scheme 9, compounds (Ic) can be converted to compounds (Id) by methods known to those skilled in the art and described for example in Org. Lett. 2019, 5848; Tetrahedron Lett. 2008, 4579; WO2021153720. For example, the reaction can be performed in organic solvent, such as toluene or chlorobenzene, in the presence of a thiation reagent, such as 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-dithione (Lawesson’s reagent). Alternatively, compounds of formula (Ic) according to the invention, wherein R1, R2, R3, R7, X, Y, Z are as defined for formula (I), and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XIII), wherein R1, R2, R3, X, Y and Z are as defined for formula (I), and R23 is hydrogen or methyl, in the presence of a sulfonylating agent of formula (VII), wherein R7 is Ci-Ce alkyl, Ci-Ce haloalkyl, Ci-C6 cycloalkyl or Ci-Ce halocycloalkyl and G is a halogen or an activating group of formula G5. This is shown in Scheme 9 below. This is shown in Sheme 10 below: Scheme 10 As shown in Scheme 10, compounds (XIII) can be converted to compounds (Ic) by methods known to those skilled in the art and described for example in Angew. Chern. Int. Ed. 2016, 5299; J. Am. Chem. Soc. 2018, 5322; WO2021153720, WO2010150192. For example, the reaction can be performed in inert organic solvent, such as methylene dichloride, dioxane or THF, in the presence of a base, such as triethylamine, pyridine or 1,8-Diazabicyclo[5.4.0]undec-7-ene. Alternatively, as known to those skilled in the art, compound (XIII) in a salt form (e.g. hydrochloric salt, hydrobromic salt, trifluoroacetic salt, paratoluensulfonic salt) can be similarly used in a conversion to compound (Ic). The compounds of formula (XIII), wherein R1, R2, R3, X, Y and Z are as defined for formula (I), and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XIV), wherein R1, R2, R3, X, Y, Z are as defined for formula (I), R21 is Ci-Ce alkyl and R23 is hydrogen or methyl. This is shown in Scheme 11 below. Scheme 11 As shown in Scheme 11, compounds (XIV) can be converted to compounds (XII) by methods known to those skilled in the art and described for example in WO2002059117, J. Med. Chem. 2003, 5238, Org. Lett. 2022, 2064. For example, the reaction can be performed in organic solvent, such as methylene dichloride, dioxane or THF, in the presence of an organic or inorganic acid, such as hydrochloric acid, trifluoroacetic acid or paratoluensulfonic acid. Compounds (XIII) can also be obtained and used in following transformations in their salt form (e.g. hydrochloric salt, hydrobromic salt, trifluoroacetic salt, paratoluensulfonic salt). The compounds of formula (XIV), wherein R1, R2, R3, X, Y, Z are as defined for formula (I) R23 is hydrogen or methyl, and R21 is Ci-Cealkyl, can be obtained by transformation of a compound of formula (XV), wherein R1, R2, R3, X, Y, Z are as defined for formula (I) with an alkylating agent of formula (Xa), wherein R21 is Ci-Ce alkyl, R23 is hydrogen or methyl, and Q is halogen, hydroxyl of sulfonate group. This is shown in Scheme 12 below. Scheme 12 (XV) Q = halogen, O (Xb) As shown in Scheme 12, compounds (XV) can be converted by an alkylative reaction with Xa (when Q is i.e. halogen or sulfonate Q1 or Q2) to compounds (XIV) by methods known to those skilled in the art and described for example in Angew. Chem. Int. Ed. 2017, 12518; WO2012101244, WO2004050619, WO2007072041. For example, the reaction can be performed in organic solvent, such as dimethylformamide, acetone or acetonitrile in the presence of a base, such as cesium carbonate, sodium hydride or sodium carbonate. Alternatively, compounds (XV) can be converted by a Mitsunobu reaction with Xa (when Q is equal to OH) by methods known to those skilled in the art and described for example in WO2012074126; Bioorg. Med. Chem. Lett. 1992, 481, Beilstein J. Org. Chem. 2006, 2, 21. For example the reaction can be performed in organic solvent, such as toluene or THF in the presence of an azadicarboxylate reagent, such as diethyl azadicarboxylate or diisopropyl azadicarboxylate, and a phospine reagent, such as triphenyl phosphine. Alterantively, compounds (XV) can be converted by an alkylative reaction with aziridine Xb to compounds (XIV) by methods known to those skilled in the art and described for example in WO2007070201. For example the reaction can be performed in organic solvent, such as acetonitrile in the presence of a base, such as potassium carbonate, sodium hydride or sodium carbonate. The compounds of formula (XV) according to the invention, wherein R1, R2, R3, X, Y and Z are as defined for formula (I), can be obtained by transformation of a compound of formula (XVI), wherein R3, X, Y, Z are as defined for formula (I) with a compound of formula (III), wherein R1 and R2 are as defined for formula (I), via an intermediate acid chloride or activated acylating agent as described below. This is shown in Scheme 13 below: Scheme 13 As shown in Scheme 13, compound XVI, is activated to compounds of formula XVII by methods known to those skilled in the art and described for example in Tetrahedron 2005, 61 (46), 10827-10852. For example, compounds of formula XVII where G is halogen are formed by treatment of compounds of formula XVI with for example, oxalyl chloride or thionyl chloride in the presence of catalytic quantities of DMF in inert solvents such as methylene dichloride or THF at temperatures between 25 to 170°C preferably 25 to 80°C. Treatment of XVII with compounds of formula III, wherein R1 and R2 are as defined in formula I, optionally in the presence of a base, e.g. triethylamine or pyridine leads to compounds of formula I. Alternatively, compounds of formula XV can be prepared by treatment of compounds of formula XVII with dicyclohexyl carbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to give the activated species XVII, wherein G is Gi or G2, in an inert solvent, e.g. pyridine, or THF optionally in the presence of a base, e.g. triethylamine, at temperatures between rt and 180°C. In addition, an acid of the formula XVI can also be activated by reaction with a coupling reagent such as propanephosphonic acid anhydride (T3P®) or O-(7-Aza-1-benzotriazolyl)-N,N,N’,N’-tetramethyluronium-hexafluorophosphat (HATU) to provide compounds of formula XVII wherein G is G3 and G4 as described for example in Synthesis 2013, 45, 1569 and J. Prakt. Chemie 1998, 340, 581. Subsequent reaction with an amine of the formula III provides compounds of formula XV. The compounds of formula (XVI), wherein R3, X, Y and Z are as defined for formula (I), can be obtained by transformation of a compound of formula (IX), wherein R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Cealkyl, in the presence of a base or an acid. This is shown in Scheme 14 below. Scheme 14 0 (IX) As shown in Scheme 14, compounds (IX) can undergo a hydrolysis reaction under basic conditions to compounds (XVI) by methods known to those skilled in the art and described for example in ACS Chemical Neuroscience 2017, 2374. For example, the reaction can be performed in water or in organic solvent, such as methanol, THF or methylene dichloride, or in mixtures; in the presence of a base, such as lithium hydroxide, sodium hydroxide or potassium hydroxide. Alternatively, the conversion of compounds (IX) into compounds (XVI) can be performed under acidic conditions by methods known to those skilled in the art and described for example in J. Med. Chern A986, 2363. For example, the reaction can be performed in water or in mixtures of water and an organic solvent, such as methanol, THF or dioxane; in the presence of an acid, such as trifluoroacetic acid, hydrochloric acid or sulfuric acid. Alternatively, compounds of formula (XIV), wherein R1, R2, R3, X, Y, Z are as defined for formula (I), R21 is Ci-C6 alkyl, and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XVIII), wherein R1, R2, R3, X, Y, Z are as defined for formula (I), and R22 is a halogen with a compound of formula (Xa), wherein R21 is Ci-Ce alkyl, R23 is hydrogen or methyl, and Q is hydroxy. This is shown in Scheme 15 below. Scheme 15 As shown in Scheme 15, compounds (XVIII) can be converted to compounds (XIV) by methods known to those skilled in the art and described for example in Tetrahedron 1988, 91; J. Am. Chern. Soc. 2010,11592, WO2020211836. For example, the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction as shown in WO2017147700 and in J. Med. Chern. 2021, 11570. The compounds of formula (XVIII) according to the invention, wherein R1, R2, R3, X, Y, Z are as defined for formula (I) and R22 is halogen, can be obtained by transformation of a compound of formula (XIX), wherein R3, X, Y, Z are as defined for formula (I) and R22 is halogen with a compound of formula (III), wherein R1 and R2 are as defined for formula (I), via an intermediate acid chloride or activated acylating agent as described below. This is shown in Scheme 16 below: Scheme 16 As shown in Scheme 16, compound XIX, is activated to compounds of formula XX by methods known to those skilled in the art and described for example in Tetrahedron 2005, 61 (46), 10827-10852,. For example, compounds of formula XX where G is halogen are formed by treatment of compounds of formula II with for example, oxalyl chloride or thionyl chloride in the presence of catalytic quantities of DMF in inert solvents such as methylene dichloride or THF at temperatures between 25 to 170°C preferably 25 to 80°C. Treatment of XX with compounds of formula III, wherein R1 and R2 are as defined in formula I, optionally in the presence of a base, e.g. triethylamine or pyridine leads to compounds of formula I. Alternatively, compounds of formula XVIII can be prepared by treatment of compounds of formula XIX with dicyclohexyl carbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to give the activated species IV, wherein G is Gi or G2, in an inert solvent, e.g. pyridine, or THF optionally in the presence of a base, e.g. triethylamine, at temperatures between rt and 180°C. In addition, an acid of the formula XIX can also be activated by reaction with a coupling reagent such as propanephosphonic acid anhydride (T3P®) or O-(7-Aza-1-benzotriazolyl)-N,N,N’,N’-tetramethyluronium-hexafluorophosphat (HATU) to provide compounds of formula XX wherein G is G3 and G4 as described for example in Synthesis 2013, 45, 1569 and J.I Prakt. Chemie 1998, 340, 581. Subsequent reaction with an amine of the formula III provides compounds of formula XVIII. The compounds of formula (XIX), wherein R3, X, Y and Z are as defined for formula (I), and R22 is halogen can be obtained by transformation of a compound of formula (XII), wherein R3, X, Y, Z are as defined for formula (I) and R22 is halogen, in the presence of a base or an acid. This is shown in Scheme 17 below. Scheme 17 (XII) (XIX) As shown in Scheme 17, compounds (XII) can undergo a hydrolysis reaction under basic conditions to compounds (XIX) by methods known to those skilled in the art and described for example in ACS Chem. Neurosci. 2017, 2374. For example, the reaction can be performed in water or in organic solvent, such as methanol, THF or methylene dichloride, or in mixtures; in the presence of a base, such as lithium hydroxide, sodium hydroxide or potassium hydroxide. Alternatively, the conversion of compounds (XII) into compounds (XIX) can be performed under acidic conditions by methods known to those skilled in the art and described for example in J. Med. Chem. 1986, 2363. For example, the reaction can be performed in water or in mixtures of water and an organic solvent, such as methanol, THF or dioxane; in the presence of an acid, such as trifluoroacetic acid, hydrochloric acid or sulfuric acid. Compounds of formula (XV), wherein R1, R2, R3, X, Y, Z are as defined for formula (I), can be obtained in two steps by transformation of a compound of formula (XVIII), wherein R1, R2, R3, X, Y, Z are as defined for formula (I) and R22 is halogen via and intermediate compound of formula (XXI), wherein R1, R2, R3, X, Y, Z are as defined for formula (I) and R20 is Ci-Ce alkyl. This is shown in Scheme 18 below. Scheme 18 As shown in Scheme 18, compounds (XVIII) can be converted to compounds (XXI) by methods known to those skilled in the art with the name of Miyaura borylation reaction and described for example in WO2021076728; J. Med. Chem. 2022, 65, 15433. For example, the reaction can be performed in organic solvent, such as THF or dioxane, in the presence of a base, such as potassium carbonate or potassium acetate and a palladium catalyst in combination with an appropriate ligand, such as 1,T-bis(diphenylphosphino)ferrocene dichloropalladium. Intermediate (XXI) can be converted into compounds of formula (XV) by methods known to those skilled in the art and described for example in WO2021127071, Tetrahedron Lett. 2014, 2082; Tetrahedron Lett. 2017, 3323; Tetrahedron 2005, 1417. For example the reaction can be performed in mixtures of water and an organic solvent, such as ethanol, acetonitrile or methylene dichloride, in the presence of hydrogen peroxide. The compounds of formula (Ie) wherein R1, R2, R4, X, Y, Z are as defined for formula (I), A is oxygen and R3 is cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, C3-C6-cycloalkyl, Ci-Ce-haloalkoxy can be obtained by transformation of a compound of formula (If), wherein R1, R2, R4, X, Y, Z are as defined for formula (I) A is oxygen and R3 is halogen. This is shown in Scheme 19 below: Scheme 19 As shown in Scheme 19, compounds (If) can reacted with compounds of formula (XXIIa) wherein R24 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-Ce-haloalkyl to compounds (Ie) wherein R3 is Ci-Ce-alkoxy and Ci-Ce-haloalkoxy by methods known to those skilled in the art and described for example in J. Med. Chem. 2021, J. Am. Chem. Soc. 2010, 11592. For example the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction. Alternatively, compounds (If) can reacted with compounds of formula (XXIIb) wherein R3 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-Ce-haloalkyl to compounds (Ie) by methods known to those skilled in the art and described for example in WO2021156787, WO2020210828, Tetrahedron Lett. 2000, 41, 6237. For example the reaction can be performed in organic solvent, such as dioxane, THF, dimethylformamide or toluene in the presence of a base, such as potassium carbonate or cesium carbonate and in the presence of a palladium catalyst with an appropriate ligand such as [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium. Alternatively, compounds (If) can be reacted with cyanide salts such as potassium ferricyanide, sodium cyanide, potassium cyanide or zinc cyanide to compounds (Ie) wherein R3 is cyano by methods known to those skilled in the art and described for example in Adv. Synth. Cat. 2017, 359, 2345, US20090062541, Synthesis 2008, 20, 3351. For example the reaction can be performed in organic solvent, such as dioxane, THF, methyl-THF, dimethylformamide, dimethyl sulfoxide or toluene in the presence of an organometallic catalyst such as couprous iodide, [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium, cupric acetate, XantPhos Pd G3, in the optional presence of a ligand such as butylimidazole, N,N'-dimethylethylenediamine, 1-methylimidazole, 1,10-Phenanthroline; in the optional presence of a base, such as potassium carbonate, sodium carbonate or cesium carbonate, in the optional presence of additives such as polyethylene glycol dodecyl ether and polymethylhydrosiloxane. The compounds of formula (Va) wherein R4, X, Y, Z are as defined for formula (I), R20 is Ci-Cealkyl and R3 is cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, Cs-Ce-cycloalkyl, Ci-Ce-haloalkoxy can be obtained by transformation of a compound of formula (Vb), wherein R4, X, Y, Z are as defined for formula (I) R20 is Ci-Cealkyl and R3 is halogen. This is shown in Scheme 20 below: Scheme 20 H°Xd24           I I R 3 .B , R       XR (XXIIa)              (XXIIb) As shown in Scheme 20, compounds (Vb) can reacted with compounds of formula (XXIIa) wherein R24 is Ci-Ce-alkyl, Cs-Ce-cycloalkyl and Ci-Ce-haloalkyl to compounds (Va) wherein R3 is Ci-Ce-alkoxy and Ci-Ce-haloalkoxy by methods known to those skilled in the art and described for example in J. Med. Chem. 2021, J. Am. Chem. Soc. 2010, 11592. For example the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction. Alternatively, compounds (Vb) can reacted with compounds of formula (XXIIb) wherein R3 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-Ce-haloalkyl to compounds (Va) by methods known to those skilled in the art and described for example in WO2021156787, WO2020210828, Tetrahedron Letters 2000, 41, 6237. For example the reaction can be performed in organic solvent, such as dioxane, THF, dimethylformamide or toluene in the presence of a base, such as potassium carbonate or cesium carbonate and in the presence of a palladium catalyst with an appropriate ligand such as [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium. Alternatively, compounds (Vb) can be reacted with cyanide salts such as potassium ferricyanide, sodium cyanide, potassium cyanide or zinc cyanide to compounds (Va) wherein R3 is cyano by methods known to those skilled in the art and described for example in Adv. Synth. Cat. 2017, 359, 2345, US20090062541, Synthesis (2008), (20), 3351. For example the reaction can be performed in organic solvent, such as dioxane, THF, methyl-THF, dimethylformamide, dimethyl sulfoxide or toluene in the presence of an organometallic catalyst such as couprous iodide, [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium, cupric acetate, XantPhos Pd G3, in the optional presence of a ligand such as butylimidazole, N,N'-dimethylethylenediamine, 1-methylimidazole, 1,10-Phenanthroline; in the optional presence of a base, such as potassium carbonate, sodium carbonate or cesium carbonate, in the optional presence of additives such as polyethylene glycol dodecyl ether and polymethylhydrosiloxane. The compounds of formula (Villa) wherein X, Y, Z are as defined for formula (I), R20 is Ci-Cealkyl, R21 is Ci-Ce alkyl, R23 is hydrogen or methyl and R3 is cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, Cs-Ce-cycloalkyl, Ci-Ce-haloalkoxy can be obtained by transformation of a compound of formula (VIlib), wherein X, Y, Z are as defined for formula (I) R20 is Ci-Cealkyl, R21 is Ci-Ce alkyl, R23 is hydrogen or methyl and and R3 is halogen. This is shown in Scheme 21 below: Scheme 21 As shown in Scheme 21, compounds (Vlllb) can reacted with compounds of formula (XXIIa) wherein R24 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-C6-haloalkyl to compounds (Villa) wherein R3 is Ci-Ce-alkoxy and Ci-Ce-haloalkoxy by methods known to those skilled in the art and described for example in J. Med. Chem. 2021, J. Am. Chem. Soc. 2010, 11592. For example the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction. Alternatively, compounds (Vlllb) can reacted with compounds of formula (XXIIb) wherein R3 is Ci-Cs-alkyl, C3-C6-cycloalkyl and Ci-Ce-haloalkyl to compounds (Villa) by methods known to those skilled in the art and described for example in WO2021156787, WO2020210828, Tetrahedron Lett. 2000, 41, 6237. For example the reaction can be performed in organic solvent, such as dioxane, THF, dimethylformamide or toluene in the presence of a base, such as potassium carbonate or cesium carbonate and in the presence of a palladium catalyst with an appropriate ligand such as [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium. Alternatively, compounds (Vlllb) can be reacted with cyanide salts such as potassium ferricyanide, sodium cyanide, potassium cyanide or zinc cyanide to compounds (Villa) wherein R3 is cyano by methods known to those skilled in the art and described for example in Adv. Synth. Cat. 2017, 359, 2345, US20090062541, Synthesis 2008, (20), 3351. For example the reaction can be performed in organic solvent, such as dioxane, THF, methyl-THF, dimethylformamide, dimethyl sulfoxide or toluene in the presence of an organometallic catalyst such as couprous iodide, [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium, cupric acetate, XantPhos Pd G3, in the optional presence of a ligand such as butylimidazole, N,N'-dimethylethylenediamine, 1-methylimidazole, 1,10-Phenanthroline; in the optional presence of a base, such as potassium carbonate, sodium carbonate or cesium carbonate, in the optional presence of additives such as polyethylene glycol dodecyl ether and polymethylhydrosiloxane. The compounds of formula (XlVa) wherein R1, R2, X, Y, Z are as defined for formula (I), R21 is Ci-Ce alkyl, R23 is hydrogen or methyl and R3 is cyano, Ci-Ce-alkyl, Ci-Ce-alkoxy, C3-C6-cycloalkyl, Ci-Ce-haloalkoxy can be obtained by transformation of a compound of formula (XlVb), wherein R1, R2, X, Y, Z are as defined for formula (I), R21 is Ci-Ce alkyl, R23 is hydrogen or methyl and and R3 is halogen. This is shown in Scheme 22 below: As shown in Scheme 21, compounds (XlVb) can reacted with compounds of formula (XXIIa) wherein R24 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-C6-haloalkyl to compounds (XlVa) wherein R3 is Ci-Ce-alkoxy and Ci-Ce-haloalkoxy by methods known to those skilled in the art and described for example in J. Med. Chem. 2021, J. Am. Chem. Soc. 2010, 11592. For example the reaction can be performed in organic solvent, such as dioxane, dimethylformamide or toluene in the presence of a base, such as sodium hydride, potassium carbonate or cesium carbonate. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction. Alternatively, compounds (XlVb) can be reacted with compounds of formula (XXIIb) wherein R3 is Ci-Ce-alkyl, C3-C6-cycloalkyl and Ci-Ce-haloalkyl to compounds (XlVa) by methods known to those skilled in the art and described for example in WO2021156787, WO2020210828, Tetrahedron Lett. 2000, 41, 6237. For example the reaction can be performed in organic solvent, such as dioxane, THF, dimethylformamide or toluene in the presence of a base, such as potassium carbonate or cesium carbonate and in the presence of a palladium catalyst with an appropriate ligand such as [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium. Alternatively, compounds (XlVb) can reacted with cyanide salts such as potassium ferricyanide, sodium cyanide, potassium cyanide or zinc cyanide to compounds (XlVa) wherein R3 is cyano by methods known to those skilled in the art and described for example in Adv. Synth. Cat. 2017, 359, 2345, US20090062541, Synthesis 2008, (20), 3351. For example the reaction can be performed in organic solvent, such as dioxane, THF, methyl-THF, dimethylformamide, dimethyl sulfoxide or toluene in the presence of an organometallic catalyst such as couprous iodide, [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium, cupric acetate, XantPhos Pd G3, in the optional presence of a ligand such as butylimidazole, N,N'-dimethylethylenediamine, 1-methylimidazole, 1,10-Phenanthroline; in the optional presence of a base, such as potassium carbonate, sodium carbonate or cesium carbonate, in the optional presence of additives such as polyethylene glycol dodecyl ether and polymethylhydrosiloxane. Compounds of formula (XXIII), wherein R3, X, Y, Z are as defined for formula (I), R21 is Ci-Ce alkyl and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XIX), wherein R3, X, Y, Z are as defined for formula (I) and R22 is a halogen with a compound of formula (Xa), wherein R21 is Ci-Ce alkyl, R23 is hydrogen or methyl and Q is hydroxy. This is shown in Scheme 23 below. Scheme 23 As shown in Scheme 23, compounds (XIX) can be converted to compounds (XXIII) by methods known to those skilled in the art and described for example in Tetrahedron 1988, 91; J. Am. Chem. Soc. 2010,11592, 5   WO2020211836. For example, the reaction can be performed in organic solvent, such as dioxane, dimethylformamide, dimethyl sulfoxide or toluene in the presence of a base, such as sodium hydride, potassium carbonate, cesium carbonate, potassium tertbutoxide, sodium hydroxide, benzyltrimethylammonium hydroxide. A palladium catalyst and an appropriate ligand can be used to facilitate the reaction as shown in WO2017147700 and in J. Med. Chem. 2021, 11570. 10 Alternatively, the compounds of formula (XIV) wherein R1, R2, R3, X, Y, Z are as defined for formula (I), R21 is Ci-C6 alkyl and R23 is hydrogen or methyl, can be obtained by transformation of a compound of formula (XXIII), wherein R3, X, Y, Z are as defined for formula (I)), R21 is Ci-Ce alkyl and R23 is hydrogen or methyl with a compound of formula (III), wherein R1 and R2 are as defined for formula (I), via an intermediate acid chloride or activated acylating agent as described below. This is shown in Scheme 24 below: 15 Scheme 24 As shown in Scheme 24, compound (XXIII), is activated to compounds of formula (XXIV) by methods known to those skilled in the art and described for example in Tetrahedron 2005, 61 (46), 10827-10852. For example, compounds of formula (XXIV) where G is halogen are formed by treatment of compounds of formula (XXIII) with for example, oxalyl chloride or thionyl chloride in the presence of catalytic quantities of DMF in inert solvents such as methylene dichloride or THF at temperatures between 25 to170 °C preferably 25 to80 °C. Treatment of (XXIV) with compounds of formula III, wherein R1 and R2 are as defined in formula I, optionally in the presence of a base, e.g. triethylamine or pyridine leads to compounds of formula (XIV). Alternatively, compounds of formula XIV can be prepared by treatment of compounds of formula XXIII with dicyclohexyl carbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to give the activated species XXIV, wherein G is Gi orG2, in an inert solvent, e.g. pyridine, or THF optionally in the presence of a base, e.g. triethylamine, at temperatures between rt and 180 °C. In addition, an acid of the formula XXIII can also be activated by reaction with a coupling reagent such as propanephosphonic acid anhydride (T3P®) or O-(7-Aza-1-benzotriazolyl)-N,N,N’,N’-tetramethyluronium-hexafluorophosphat (HATU) to provide compounds of formula XXIV wherein G is G3 and G4 as described for example in Synthesis 2013, 45, 1569 and J. Prakt. Chern. 1998, 340, 581. Subsequent reaction with an amine of the formula III provides compounds of formula XIV. Depending on the procedure or the reaction conditions, the reactants can be reacted in the presence of a base. Examples of suitable bases are alkali metal or alkaline earth metal hydroxides, alkali metal or alkaline earth metal hydrides, alkali metal or alkaline earth metal amides, alkali metal or alkaline earth metal alkoxides, alkali metal or alkaline earth metal acetates, alkali metal or alkaline earth metal carbonates, alkali metal or alkaline earth metal dialkylamides or alkali metal or alkaline earth metal alkylsilylamides, alkylamines, alkylenediamines, free or N-alkylated saturated or unsaturated cycloalkylamines, basic heterocycles, ammonium hydroxides and carbocyclic amines. Examples which may be mentioned are sodium hydroxide, sodium hydride, sodium amide, sodium methoxide, sodium acetate, sodium carbonate, potassium tert-butoxide, potassium hydroxide, potassium carbonate, potassium hydride, lithium diisopropylamide, potassium bis(trimethylsilyl)amide, calcium hydride, triethylamine, diisopropylethylamine, triethylenediamine, cyclohexylamine, N-cyclohexyl-N,N-dimethylamine, N,N-diethylaniline, pyridine, 4-(N,N-dimethylamino)pyridine, quinuclidine, N-methylmorpholine, benzyltrimethylammonium hydroxide and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The reactants can be reacted with each other as such, i.e. without adding a solvent or diluent. In most cases, however, it is advantageous to add an inert solvent or diluent or a mixture of these. If the reaction is carried out in the presence of a base, bases which are employed in excess, such as triethylamine, pyridine, N-methylmorpholine or N,N-diethylaniline, may also act as solvents or diluents. The reactions are advantageously carried out in a temperature range from approximately -80°C to approximately +140°C, preferably from approximately -30°C to approximately +100°C, in many cases in the range between ambient temperature and approximately +80°C. Depending on the choice of the reaction conditions and starting materials which are suitable in each case, it is possible, for example, in one reaction step only to replace one substituent by another substituent according to the invention, or a plurality of substituents can be replaced by other substituents according to the invention in the same reaction step. Salts of compounds of formula I can be prepared in a manner known per se. Thus, for example, acid addition salts of compounds of formula I are obtained by treatment with a suitable acid or a suitable ion exchanger reagent and salts with bases are obtained by treatment with a suitable base or with a suitable ion exchanger reagent. Salts of compounds of formula I can be converted in the customary manner into the free compounds I, acid addition salts, for example, by treatment with a suitable basic compound or with a suitable ion exchanger reagent and salts with bases, for example, by treatment with a suitable acid or with a suitable ion exchanger reagent. Salts of compounds of formula I can be converted in a manner known perse into other salts of compounds of formula I, acid addition salts, for example, into other acid addition salts, for example by treatment of a salt of inorganic acid such as hydrochloride with a suitable metal salt such as a sodium, barium or silver salt, of an acid, for example with silver acetate, in a suitable solvent in which an inorganic salt which forms, for example silver chloride, is insoluble and thus precipitates from the reaction mixture. Depending on the procedure or the reaction conditions, the compounds of formula I, which have saltforming properties can be obtained in free form or in the form of salts. The compounds of formula I and, where appropriate, the tautomers thereof, in each case in free form or in salt form, can be present in the form of one of the isomers which are possible or as a mixture of these, for example in the form of pure isomers, such as antipodes and / or diastereomers, or as isomer mixtures, such as enantiomer mixtures, for example racemates, diastereomer mixtures or racemate mixtures, depending on the number, absolute and relative configuration of asymmetric carbon atoms which occur in the molecule and / or depending on the configuration of non-aromatic double bonds which occur in the molecule; the invention relates to the pure isomers and also to all isomer mixtures which are possible and is to be understood in each case in this sense hereinabove and hereinbelow, even when stereochemical details are not mentioned specifically in each case. Diastereomer mixtures or racemate mixtures of compounds of formula I, in free form or in salt form, which can be obtained depending on which starting materials and procedures have been chosen can be separated in a known manner into the pure diasteromers or racemates on the basis of the physicochemical differences of the components, for example by fractional crystallization, distillation and / or chromatography. Enantiomer mixtures, such as racemates, which can be obtained in a similar manner can be resolved into the optical antipodes by known methods, for example by recrystallization from an optically active solvent, by chromatography on chiral adsorbents, for example high-performance liquid chromatography (HPLC) on acetyl celulose, with the aid of suitable microorganisms, by cleavage with specific, immobilized enzymes, via the formation of inclusion compounds, for example using chiral crown ethers, where only one enantiomer is complexed, or by conversion into diastereomeric salts, for example by reacting a basic endproduct racemate with an optically active acid, such as a carboxylic acid, for example camphor, tartaric or malic acid, or sulfonic acid, for example camphorsulfonic acid, and separating the diastereomer mixture which can be obtained in this manner, for example by fractional crystallization based on their differing solubilities, to give the diastereomers, from which the desired enantiomer can be set free by the action of suitable agents, for example basic agents. Pure diastereomers or enantiomers can be obtained according to the invention not only by separating suitable isomer mixtures, but also by generally known methods of diastereoselective or enantioselective synthesis, for example by carrying out the process according to the invention with starting materials of a suitable stereochemistry. N-oxides can be prepared by reacting a compound of the formula I with a suitable oxidizing agent, for example the H2O2 / urea adduct in the presence of an acid anhydride, e.g. trifluoroacetic anhydride. Such oxidations are known from the literature, for example from J. Med. Chem., 32 (12), 2561-73, 1989 or WO 2000 / 15615. It is advantageous to isolate or synthesize in each case the biologically more effective isomer, for example enantiomer or diastereomer, or isomer mixture, for example enantiomer mixture or diastereomer mixture, if the individual components have a different biological activity. The compounds of formula I and, where appropriate, the tautomers thereof, in each case in free form or in salt form, can, if appropriate, also be obtained in the form of hydrates and / or include other solvents, for example those which may have been used for the crystallization of compounds which are present in solid form. The compounds of formula (I) according to the following Tables 1 to 5 can be prepared according to the methods described above. The examples which follow are intended to illustrate the invention and show preferred compounds of formula (I), in the form of a compound of formulae (1-1 a), (l-2a), (l-3a), (l-4a) and (l-5a). Table 1: Makes available 1447 compounds of the formula (l-1a), where the substituents R1, R2’ R3, R6 and R7 are designated in each row below: Index R2 R3 R6 R7 R1 1 H Cl H cf3 ethyl Index R3 (OlililW R1 2 I H ~~~~ Cl H chf2 ethyl 3 H Cl H iPr ethyl 4 H Cl H cyclopropyl ethyl 5 H Cl methyl cf3 ethyl 6 H Cl methyl chf2 ethyl 7 H Cl methyl iPr ethyl 8 H Cl methyl cyclopropyl ethyl 9 H Cl methoxymethyl cf3 ethyl 10 H Cl methoxymethyl chf2 ethyl 11 H Cl methoxymethyl iPr ethyl 12 H Cl methoxymethyl cyclopropyl ethyl 13 H Cl acetyl cf3 ethyl 14 H Cl acetyl chf2 ethyl 15 H Cl acetyl iPr ethyl 16 H Cl acetyl cyclopropyl ethyl 17 H Me H cf3 ethyl 18 H Me H chf2 ethyl 19 H Me H iPr ethyl 20 H Me H cyclopropyl ethyl 21 H Me methyl cf3 ethyl 22 H Me methyl chf2 ethyl 23 H Me methyl iPr ethyl 24 H Me methyl cyclopropyl ethyl 25 H Me methoxymethyl cf3 ethyl 26 H Me methoxymethyl chf2 ethyl 27 H Me methoxymethyl iPr ethyl 28 H Me methoxymethyl cyclopropyl ethyl 29 H Me acetyl cf3 ethyl 30 H Me acetyl chf2 ethyl 31 H Me acetyl iPr ethyl 32 H Me acetyl cyclopropyl ethyl 33 methyl Cl H cf3 ethyl 34 methyl Cl H chf2 ethyl 35 methyl Cl H iPr ethyl 36 methyl Cl H cyclopropyl ethyl 37 methyl Cl methyl cf3 ethyl 38 methyl Cl methyl chf2 ethyl 39 methyl Cl methyl iPr ethyl 40 methyl Cl methyl cyclopropyl ethyl 41 methyl Cl methoxymethyl cf3 ethyl 42 methyl Cl methoxymethyl chf2 ethyl 43 methyl Cl methoxymethyl iPr ethyl 44 methyl Cl methoxymethyl cyclopropyl ethyl 45 methyl Cl acetyl cf3 ethyl 46 methyl Cl acetyl chf2 ethyl 47 methyl Cl acetyl iPr ethyl Index R3 pBlililW R1 48 methyl ~     Cl acetyl cyclopropyl ethy 49 methyl Me H cf3 ethy 50 methyl Me H      ...... chf2 ethy 51 methyl Me H iPr ethy 52 methyl Me H cyclopropyl ethy 53 methyl Me methyl cf3 ethy 54 methyl Me methyl chf2 ethy 55 methyl Me methyl iPr ethy 56 methyl Me methyl cyclopropyl ethy 57 methyl Me methoxymethyl cf3 ethy 58 methyl Me methoxymethyl chf2 ethy 59 methyl Me methoxymethyl iPr ethy 60 methyl Me methoxymethyl cyclopropyl ethy 61 methyl Me acetyl cf3 ethy 62 methyl Me acetyl chf2 ethy 63 methyl Me acetyl iPr ethy 64 methyl Me acetyl cyclopropyl ethy 65 acetyl Cl H cf3 ethy 66 acetyl Cl H chf2 ethy 67 acetyl Cl H iPr ethy 68 acetyl Cl H cyclopropyl ethy 69 acetyl Cl methyl cf3 ethy 70 acetyl d methyl chf2 ethy 71 acetyl Cl methyl iPr ethy 72 acetyl Cl methyl cyclopropyl ethy 73 acetyl Cl methoxymethyl cf3 ethy 74 acetyl Cl methoxymethyl chf2 ethy 75 acetyl Cl methoxymethyl iPr ethy 76 acetyl Cl methoxymethyl cyclopropyl ethy 77 acetyl Cl acetyl cf3 ethy 78 acetyl Cl acetyl CHF2 ethy 79 acetyl Cl acetyl iPr ethy 80 acetyl Cl acetyl cyclopropyl ethy 81 acetyl Me H cf3 ethy 82 acetyl Me H CHF2 ethy 83 acetyl Me H iPr ethy 84 acetyl Me H cyclopropyl ethy 85 acetyl Me methyl cf3 ethy 86 acetyl Me methyl chf2 ethy 87 acetyl Me methyl iPr ethy 88 acetyl Me methyl cyclopropyl ethy 89 acetyl Me methoxymethyl cf3 ethy 90 acetyl Me methoxymethyl chf2 ethy 91 acetyl Me methoxymethyl iPr ethy 92 acetyl Me methoxymethyl cyclopropyl ethy 93 acetyl Me acetyl cf3 ethy Index R3 11 R1 94 acetyl Me acetyl chf2 ethyl 95 acetyl Me acetyl iPr ethyl 96 acetyl Me acetyl cyclopropyl ethyl 97 2-methyl propanoyl Cl H cf3 ethyl 98 2-methyl propanoyl Cl H chf2 ethyl 99 2-methyl propanoyl Cl H iPr ethyl 100 2-methyl propanoyl Cl H cyclopropyl ethyl 101 2-methyl propanoyl Cl methyl cf3 ethyl 102 2-methyl propanoyl Cl methyl chf2 ethyl 103 2-methyl propanoyl Cl methyl iPr ethyl 104 2-methyl propanoyl Cl methyl cyclopropyl ethyl 105 2-methyl propanoyl Cl methoxymethyl cf3 ethyl 106 2-methyl propanoyl Cl methoxymethyl chf2 ethyl 107 2-methyl propanoyl Cl methoxymethyl iPr ethyl 108 2-methyl propanoyl Cl methoxymethyl cyclopropyl ethyl 109 2-methyl propanoyl Cl acetyl cf3 ethyl 110 2-methyl propanoyl Cl acetyl chf2 ethyl 111 2-methyl propanoyl Cl acetyl iPr ethyl 112 2-methyl propanoyl Cl acetyl cyclopropyl ethyl 113 2-methyl propanoyl Me H cf3 ethyl 114 2-methyl propanoyl Me H chf2 ethyl 115 2-methyl propanoyl Me H iPr ethyl 116 2-methyl propanoyl Me H cyclopropyl ethyl 117 2-methyl propanoyl Me methyl cf3 ethyl 118 2-methyl propanoyl Me methyl chf2 ethyl 119 2-methyl propanoyl Me methyl iPr ethyl 120 2-methyl propanoyl Me methyl cyclopropyl ethyl 121 2-methyl propanoyl Me methoxymethyl cf3 ethyl 122 2-methyl propanoyl Me methoxymethyl chf2 ethyl 123 2-methyl propanoyl Me methoxymethyl iPr ethyl 124 2-methyl propanoyl Me methoxymethyl cyclopropyl ethyl 125 2-methyl propanoyl Me acetyl cf3 ethyl 126 2-methyl propanoyl Me acetyl chf2 ethyl 127 2-methyl propanoyl Me acetyl iPr ethyl 128 2-methyl propanoyl Me acetyl cyclopropyl ethyl 129 H Cl H cf3 isopropyl 130 H Cl H chf2 isopropyl 131 H Cl H iPr isopropyl 132 H Cl H cyclopropyl isopropyl 133 H Cl methyl cf3 isopropyl 134 H Cl methyl chf2 isopropyl 135 H Cl methyl iPr isopropyl 136 H Cl methyl cyclopropyl isopropyl 137 H Cl methoxymethyl cf3 isopropyl 138 H Cl methoxymethyl chf2 isopropyl 139 H Cl methoxymethyl iPr isopropyl Index R3 IWlilllW R1 140 I H ~~~~ Cl methoxymethyl cyclopropyl isopropyl 141 H Cl acetyl cf3 isopropyl 142 H Cl acetyl chf2 isopropyl 143 H Cl acetyl iPr isopropyl 144 H Cl acetyl cyclopropyl isopropyl 145 H Me H cf3 isopropyl 146 H Me H chf2 isopropyl 147 H Me H iPr isopropyl 148 H Me H cyclopropyl isopropyl 149 H Me methyl cf3 isopropyl 150 H Me methyl chf2 isopropyl 151 H Me methyl iPr isopropyl 152 H Me methyl cyclopropyl isopropyl 153 H Me methoxymethyl cf3 isopropyl 154 H Me methoxymethyl chf2 isopropyl 155 H Me methoxymethyl iPr isopropyl 156 H Me methoxymethyl cyclopropyl isopropyl 157 H Me acetyl cf3 isopropyl 158 H Me acetyl chf2 isopropyl 159 H Me acetyl iPr isopropyl 160 H Me acetyl cyclopropyl isopropyl 161 methyl Cl H cf3 isopropyl 162 methyl Cl H chf2 isopropyl 163 methyl Cl H iPr isopropyl 164 methyl Cl H cyclopropyl isopropyl 165 methyl Cl methyl cf3 isopropyl 166 methyl Cl methyl chf2 isopropyl 167 methyl Cl methyl iPr isopropyl 168 methyl Cl methyl cyclopropyl isopropyl 169 methyl Cl methoxymethyl cf3 isopropyl 170 methyl Cl methoxymethyl chf2 isopropyl 171 methyl Cl methoxymethyl iPr isopropyl 172 methyl Cl methoxymethyl cyclopropyl isopropyl 173 methyl Cl acetyl cf3 isopropyl 174 methyl Cl acetyl chf2 isopropyl 175 methyl Cl acetyl iPr isopropyl 176 methyl Cl acetyl cyclopropyl isopropyl 177 methyl Me H cf3 isopropyl 178 methyl Me H chf2 isopropyl 179 methyl Me H iPr isopropyl 180 methyl Me H cyclopropyl isopropyl 181 methyl Me methyl cf3 isopropyl 182 methyl Me methyl chf2 isopropyl 183 methyl Me methyl iPr isopropyl 184 methyl Me methyl cyclopropyl isopropyl 185 methyl Me methoxymethyl cf3 isopropyl Index R3 R1 186 methyl Me methoxymethyl chf2 isopropyl 187 methyl Me methoxymethyl iPr isopropyl 188 methyl Me methoxymethyl cyclopropyl isopropyl 189 methyl Me acetyl cf3 isopropyl 190 methyl Me acetyl chf2 isopropyl 191 methyl Me acetyl iPr isopropyl 192 methyl Me acetyl cyclopropyl isopropyl 193 acetyl Cl H cf3 isopropyl 194 acetyl Cl H chf2 isopropyl 195 acetyl Cl H iPr isopropyl 196 acetyl Cl H cyclopropyl isopropyl 197 acetyl Cl methyl cf3 isopropyl 198 acetyl Cl methyl chf2 isopropyl 199 acetyl Cl methyl iPr isopropyl 200 acetyl Cl methyl cyclopropyl isopropyl 201 acetyl Cl methoxymethyl cf3 isopropyl 202 acetyl Cl methoxymethyl chf2 isopropyl 203 acetyl Cl methoxymethyl iPr isopropyl 204 acetyl Cl methoxymethyl cyclopropyl isopropyl 205 acetyl Cl acetyl cf3 isopropyl 206 acetyl Cl acetyl chf2 isopropyl 207 acetyl Cl acetyl iPr isopropyl 208 acetyl Cl acetyl cyclopropyl isopropyl 209 acetyl Me H cf3 isopropyl 210 acetyl Me H chf2 isopropyl 211 acetyl Me H iPr isopropyl 212 acetyl Me H cyclopropyl isopropyl 213 acetyl Me methyl cf3 isopropyl 214 acetyl Me methyl chf2 isopropyl 215 acetyl Me methyl iPr isopropyl 216 acetyl Me methyl cyclopropyl isopropyl 217 acetyl Me methoxymethyl cf3 isopropyl 218 acetyl Me methoxymethyl chf2 isopropyl 219 acetyl Me methoxymethyl iPr isopropyl 220 acetyl Me methoxymethyl cyclopropyl isopropyl 221 acetyl Me acetyl cf3 isopropyl 222 acetyl Me acetyl chf2 isopropyl 223 acetyl Me acetyl iPr isopropyl 224 acetyl Me acetyl cyclopropyl isopropyl 225 2-methyl propanoyl Cl H cf3 isopropyl 226 2-methyl propanoyl Cl H chf2 isopropyl 227 2-methyl propanoyl Cl H iPr isopropyl 228 2-methyl propanoyl Cl H cyclopropyl isopropyl 229 2-methyl propanoyl Cl methyl cf3 isopropyl 230 2-methyl propanoyl Cl methyl chf2 isopropyl 231 2-methyl propanoyl Cl methyl iPr isopropyl Index BIBBBBIIIIII / lli R3 R1 232 2-methyl propanoyl Cl methyl cyclopropyl isopropyl 233 2-methyl propanoyl Cl methoxymethyl cf3 isopropyl 234 2-methyl propanoyl Cl methoxymethyl chf2 isopropyl 235 2-methyl propanoyl Cl methoxymethyl iPr isopropyl 236 2-methyl propanoyl Cl methoxymethyl cyclopropyl isopropyl 237 2-methyl propanoyl Cl acetyl cf3 isopropyl 238 2-methyl propanoyl Cl acetyl chf2 isopropyl 239 2-methyl propanoyl Cl acetyl iPr isopropyl 240 2-methyl propanoyl Cl acetyl cyclopropyl isopropyl 241 2-methyl propanoyl Me H cf3 isopropyl 242 2-methyl propanoyl Me H chf2 isopropyl 243 2-methyl propanoyl Me H iPr isopropyl 244 2-methyl propanoyl Me H cyclopropyl isopropyl 245 2-methyl propanoyl Me methyl cf3 isopropyl 246 2-methyl propanoyl Me methyl chf2 isopropyl 247 2-methyl propanoyl Me methyl iPr isopropyl 248 2-methyl propanoyl Me methyl cyclopropyl isopropyl 249 2-methyl propanoyl Me methoxymethyl cf3 isopropyl 250 2-methyl propanoyl Me methoxymethyl chf2 isopropyl 251 2-methyl propanoyl Me methoxymethyl iPr isopropyl 252 2-methyl propanoyl Me methoxymethyl cyclopropyl isopropyl 253 2-methyl propanoyl Me acetyl cf3 isopropyl 254 2-methyl propanoyl Me acetyl chf2 isopropyl 255 2-methyl propanoyl Me acetyl iPr isopropyl 256 2-methyl propanoyl Me acetyl cyclopropyl isopropyl 257 H Cl H cf3 propargyl 258 H Cl H chf2 propargyl 259 H Cl H iPr propargyl 260 H Cl H cyclopropyl propargyl 261 H Cl methyl cf3 propargyl 262 H Cl methyl chf2 propargyl 263 H Cl methyl iPr propargyl 264 H Cl methyl cyclopropyl propargyl 265 H Cl methoxymethyl cf3 propargyl 266 H Cl methoxymethyl chf2 propargyl 267 H Cl methoxymethyl iPr propargyl 268 H Cl methoxymethyl cyclopropyl propargyl 269 H Cl acetyl cf3 propargyl 270 H Cl acetyl chf2 propargyl 271 H Cl acetyl iPr propargyl 272 H Cl acetyl cyclopropyl propargyl 273 H Me H cf3 propargyl 274 H Me H chf2 propargyl 275 H Me H iPr propargyl 276 H Me H cyclopropyl propargyl 277 H Me methyl cf3 propargyl Index R3 Idiiii® R1 278 I H         ‘ Me methyl chf2 propargyl 279 H Me methyl IPr propargyl 280 H Me methyl cyclopropyl propargyl 281 H Me methoxymethyl cf3 propargyl 282 H Me methoxymethyl chf2 propargyl 283 H Me methoxymethyl iPr propargyl 284 H Me methoxymethyl cyclopropyl propargyl 285 H Me acetyl cf3 propargyl 286 H Me acetyl chf2 propargyl 287 H Me acetyl iPr propargyl 288 H Me acetyl cyclopropyl propargyl 289 methyl Cl H cf3 propargyl 290 methyl Cl H chf2 propargyl 291 methyl Cl H iPr propargyl 292 methyl Cl H cyclopropyl propargyl 293 methyl Cl methyl cf3 propargyl 294 methyl Cl methyl chf2 propargyl 295 methyl Cl methyl iPr propargyl 296 methyl Cl methyl cyclopropyl propargyl 297 methyl Cl methoxymethyl cf3 propargyl 298 methyl Cl methoxymethyl chf2 propargyl 299 methyl Cl methoxymethyl iPr propargyl 300 methyl Cl methoxymethyl cyclopropyl propargyl 301 methyl Cl acetyl cf3 propargyl 302 methyl Cl acetyl chf2 propargyl 303 methyl Cl acetyl iPr propargyl 304 methyl Cl acetyl cyclopropyl propargyl 305 methyl Me H cf3 propargyl 306 methyl Me H chf2 propargyl 307 methyl Me H iPr propargyl 308 methyl Me H cyclopropyl propargyl 309 methyl Me methyl cf3 propargyl 310 methyl Me methyl chf2 propargyl 311 methyl Me methyl iPr propargyl 312 methyl Me methyl cyclopropyl propargyl 313 methyl Me methoxymethyl cf3 propargyl 314 methyl Me methoxymethyl chf2 propargyl 315 methyl Me methoxymethyl iPr propargyl 316 methyl Me methoxymethyl cyclopropyl propargyl 317 methyl Me acetyl cf3 propargyl 318 methyl Me acetyl chf2 propargyl 319 methyl Me acetyl iPr propargyl 320 methyl Me acetyl cyclopropyl propargyl 321 acetyl Cl H cf3 propargyl 322 acetyl Cl H chf2 propargyl 323 acetyl Cl H iPr propargyl Index R3 R1 324 acetyl Cl H cyclopropyl propargyl 325 acetyl Cl methyl cf3 propargyl 326 acetyl Cl methyl chf2 propargyl 327 acetyl Cl methyl iPr propargyl 328 acetyl Cl methyl cyclopropyl propargyl 329 acetyl Cl methoxymethyl cf3 propargyl 330 acetyl Cl methoxymethyl chf2 propargyl 331 acetyl Cl methoxymethyl IPr propargyl 332 acetyl Cl methoxymethyl cyclopropyl propargyl 333 acetyl Cl acetyl cf3 propargyl 334 acetyl Cl acetyl chf2 propargyl 335 acetyl Cl acetyl iPr propargyl 336 acetyl Cl acetyl cyclopropyl propargyl 337 acetyl Me H cf3 propargyl 338 acetyl Me H chf2 propargyl 339 acetyl Me H iPr propargyl 340 acetyl Me H cyclopropyl propargyl 341 acetyl Me methyl cf3 propargyl 342 acetyl Me methyl chf2 propargyl 343 acetyl Me methyl iPr propargyl 344 acetyl Me methyl cyclopropyl propargyl 345 acetyl Me methoxymethyl cf3 propargyl 346 acetyl Me methoxymethyl chf2 propargyl 347 acetyl Me methoxymethyl iPr propargyl 348 acetyl Me methoxymethyl cyclopropyl propargyl 349 acetyl Me acetyl cf3 propargyl 350 acetyl Me acetyl chf2 propargyl 351 acetyl Me acetyl iPr propargyl 352 acetyl Me acetyl cyclopropyl propargyl 353 2-methyl propanoyl Cl H cf3 propargyl 354 2-methyl propanoyl Cl H chf2 propargyl 355 2-methyl propanoyl Cl H iPr propargyl 356 2-methyl propanoyl Cl H cyclopropyl propargyl 357 2-methyl propanoyl Cl methyl cf3 propargyl 358 2-methyl propanoyl Cl methyl chf2 propargyl 359 2-methyl propanoyl Cl methyl iPr propargyl 360 2-methyl propanoyl Cl methyl cyclopropyl propargyl 361 2-methyl propanoyl Cl methoxymethyl cf3 propargyl 362 2-methyl propanoyl Cl methoxymethyl chf2 propargyl 363 2-methyl propanoyl Cl methoxymethyl iPr propargyl 364 2-methyl propanoyl Cl methoxymethyl cyclopropyl propargyl 365 2-methyl propanoyl Cl acetyl cf3 propargyl 366 2-methyl propanoyl Cl acetyl chf2 propargyl 367 2-methyl propanoyl Cl acetyl iPr propargyl 368 2-methyl propanoyl Cl acetyl cyclopropyl propargyl 369 2-methyl propanoyl Me H cf3 propargyl Index R3 370 2-methyl propanoyl Me H                 "" chf2 propargyl 371 2-methyl propanoyl Me H iPr propargyl 372 2-methyl propanoyl Me H      ...... cyclopropyl propargyl 373 2-methyl propanoyl Me methyl cf3 propargyl 374 2-methyl propanoyl Me methyl chf2 propargyl 375 2-methyl propanoyl Me methyl iPr propargyl 376 2-methyl propanoyl Me methyl cyclopropyl propargyl 377 2-methyl propanoyl Me methoxymethyl cf3 propargyl 378 2-methyl propanoyl Me methoxymethyl chf2 propargyl 379 2-methyl propanoyl Me methoxymethyl iPr propargyl 380 2-methyl propanoyl Me methoxymethyl cyclopropyl propargyl 381 2-methyl propanoyl Me acetyl cf3 propargyl 382 2-methyl propanoyl Me acetyl chf2 propargyl 383 2-methyl propanoyl Me acetyl iPr propargyl 384 2-methyl propanoyl Me acetyl cyclopropyl propargyl 385 H Cl H cf3 2,2,2-trifluoroethyl 386 H Cl H............. chf2 2,2,2-trifluoroethyl 387 H Cl H iPr 2,2,2-trifluoroethyl 388 H      ......... Cl H cyclopropyl 2,2,2-trifluoroethyl 389 H Cl methyl cf3 2,2,2-trifluoroethyl 390 H Cl methyl chf2 2,2,2-trifluoroethyl 391 H Cl methyl iPr 2,2,2-trifluoroethyl 392 H d methyl cyclopropyl 2,2,2-trifluoroethyl 393 H Cl methoxymethyl cf3 2,2,2-trifluoroethyl 394 H Cl methoxymethyl chf2 2,2,2-trifluoroethyl 395 H Cl methoxymethyl iPr 2,2,2-trifluoroethyl 396 H Cl methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 397 H Cl acetyl cf3 2,2,2-trifluoroethyl 398 H Cl acetyl chf2 2,2,2-trifluoroethyl 399 H Cl acetyl iPr 2,2,2-trifluoroethyl 400 H Cl acetyl cyclopropyl 2,2,2-trifluoroethyl 401 H Me H cf3 2,2,2-trifluoroethyl 402 H Me H CHF2 2,2,2-trifluoroethyl 403 H Me H iPr 2,2,2-trifluoroethyl 404 H Me H cyclopropyl 2,2,2-trifluoroethyl 405 H Me methyl cf3 2,2,2-trifluoroethyl 406 H Me methyl chf2 2,2,2-trifluoroethyl 407 H Me methyl iPr 2,2,2-trifluoroethyl 408 H Me methyl cyclopropyl 2,2,2-trifluoroethyl 409 H Me methoxymethyl cf3 2,2,2-trifluoroethyl 410 H Me methoxymethyl chf2 2,2,2-trifluoroethyl 411 H Me methoxymethyl iPr 2,2,2-trifluoroethyl 412 H Me methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 413 H Me acetyl cf3 2,2,2-trifluoroethyl 414 H Me acetyl chf2 2,2,2-trifluoroethyl 415 H Me acetyl iPr 2,2,2-trifluoroethyl Index R3 f®R^ 416 I H ~~~~ Me acetyl cyclopropyl 2,2,2-trifluoroethyl 417 methyl Cl H cf3 2,2,2-trifluoroethyl 418 methyl Cl H      ...... chf2 2,2,2-trifluoroethyl 419 methyl Cl H iPr 2,2,2-trifluoroethyl 420 methyl Cl H cyclopropyl 2,2,2-trifluoroethyl 421 methyl Cl methyl cf3 2,2,2-trifluoroethyl 422 methyl Cl methyl chf2 2,2,2-trifluoroethyl 423 methyl Cl methyl iPr 2,2,2-trifluoroethyl 424 methyl Cl methyl cyclopropyl 2,2,2-trifluoroethyl 425 methyl Cl methoxymethyl cf3 2,2,2-trifluoroethyl 426 methyl Cl methoxymethyl chf2 2,2,2-trifluoroethyl 427 methyl Cl methoxymethyl iPr 2,2,2-trifluoroethyl 428 methyl Cl methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 429 methyl Cl acetyl cf3 2,2,2-trifluoroethyl 430 methyl Cl acetyl chf2 2,2,2-trifluoroethyl 431 methyl Cl acetyl iPr 2,2,2-trifluoroethyl 432 methyl Cl acetyl cyclopropyl 2,2,2-trifluoroethyl 433 methyl Me H cf3 2,2,2-trifluoroethyl 434 methyl Me H chf2 2,2,2-trifluoroethyl 435 methyl Me H iPr 2,2,2-trifluoroethyl 436 methyl Me H cyclopropyl 2,2,2-trifluoroethyl 437 methyl Me methyl cf3 2,2,2-trifluoroethyl 438 methyl Me methyl chf2 2,2,2-trifluoroethyl 439 methyl Me methyl iPr 2,2,2-trifluoroethyl 440 methyl Me methyl cyclopropyl 2,2,2-trifluoroethyl 441 methyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 442 methyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 443 methyl Me methoxymethyl iPr 2,2,2-trifluoroethyl 444 methyl Me methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 445 methyl Me acetyl cf3 2,2,2-trifluoroethyl 446 methyl Me acetyl CHF2 2,2,2-trifluoroethyl 447 methyl Me acetyl iPr 2,2,2-trifluoroethyl 448 methyl Me acetyl cyclopropyl 2,2,2-trifluoroethyl 449 acetyl Cl H cf3 2,2,2-trifluoroethyl 450 acetyl Cl H CHF2 2,2,2-trifluoroethyl 451 acetyl Cl H iPr 2,2,2-trifluoroethyl 452 acetyl Cl H cyclopropyl 2,2,2-trifluoroethyl 453 acetyl Cl methyl cf3 2,2,2-trifluoroethyl 454 acetyl Cl methyl chf2 2,2,2-trifluoroethyl 455 acetyl Cl methyl iPr 2,2,2-trifluoroethyl 456 acetyl Cl methyl cyclopropyl 2,2,2-trifluoroethyl 457 acetyl Cl methoxymethyl cf3 2,2,2-trifluoroethyl 458 acetyl Cl methoxymethyl chf2 2,2,2-trifluoroethyl 459 acetyl Cl methoxymethyl iPr 2,2,2-trifluoroethyl 460 acetyl Cl methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 461 acetyl Cl acetyl cf3 2,2,2-trifluoroethyl Index R3 pBlililW 462 acetyl Cl acetyl chf2 2,2,2-trifluoroethyl 463 acetyl Cl acetyl iPr 2,2,2-trifluoroethyl 464 acetyl Cl acetyl cyclopropyl 2,2,2-trifluoroethyl 465 acetyl Me H cf3 2,2,2-trifluoroethyl 466 acetyl Me H chf2 2,2,2-trifluoroethyl 467 acetyl Me H iPr 2,2,2-trifluoroethyl 468 acetyl Me H cyclopropyl 2,2,2-trifluoroethyl 469 acetyl Me methyl cf3 2,2,2-trifluoroethyl 470 acetyl Me methyl chf2 2,2,2-trifluoroethyl 471 acetyl Me methyl iPr 2,2,2-trifluoroethyl 472 acetyl Me methyl cyclopropyl 2,2,2-trifluoroethyl 473 acetyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 474 acetyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 475 acetyl Me methoxymethyl iPr 2,2,2-trifluoroethyl 476 acetyl Me methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 477 acetyl Me acetyl cf3 2,2,2-trifluoroethyl 478 acetyl Me acetyl chf2 2,2,2-trifluoroethyl 479 acetyl Me acetyl iPr 2,2,2-trifluoroethyl 480 acetyl Me acetyl cyclopropyl 2,2,2-trifluoroethyl 481 2-methyl propanoyl Cl H cf3 2,2,2-trifluoroethyl 482 2-methyl propanoyl Cl H chf2 2,2,2-trifluoroethyl 483 2-methyl propanoyl Cl H iPr 2,2,2-trifluoroethyl 484 2-methyl propanoyl d H cyclopropyl 2,2,2-trifluoroethyl 485 2-methyl propanoyl Cl methyl cf3 2,2,2-trifluoroethyl 486 2-methyl propanoyl Cl methyl chf2 2,2,2-trifluoroethyl 487 2-methyl propanoyl Cl methyl iPr 2,2,2-trifluoroethyl 488 2-methyl propanoyl Cl methyl cyclopropyl 2,2,2-trifluoroethyl 489 2-methyl propanoyl Cl methoxymethyl cf3 2,2,2-trifluoroethyl 490 2-methyl propanoyl Cl methoxymethyl chf2 2,2,2-trifluoroethyl 491 2-methyl propanoyl Cl methoxymethyl iPr 2,2,2-trifluoroethyl 492 2-methyl propanoyl Cl methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 493 2-methyl propanoyl Cl acetyl cf3 2,2,2-trifluoroethyl 494 2-methyl propanoyl Cl acetyl CHF2 2,2,2-trifluoroethyl 495 2-methyl propanoyl Cl acetyl iPr 2,2,2-trifluoroethyl 496 2-methyl propanoyl Cl acetyl cyclopropyl 2,2,2-trifluoroethyl 497 2-methyl propanoyl Me H cf3 2,2,2-trifluoroethyl 498 2-methyl propanoyl Me H chf2 2,2,2-trifluoroethyl 499 2-methyl propanoyl Me H iPr 2,2,2-trifluoroethyl 500 2-methyl propanoyl Me H cyclopropyl 2,2,2-trifluoroethyl 501 2-methyl propanoyl Me methyl cf3 2,2,2-trifluoroethyl 502 2-methyl propanoyl Me methyl chf2 2,2,2-trifluoroethyl 503 2-methyl propanoyl Me methyl iPr 2,2,2-trifluoroethyl 504 2-methyl propanoyl Me methyl cyclopropyl 2,2,2-trifluoroethyl 505 2-methyl propanoyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 506 2-methyl propanoyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 507 2-methyl propanoyl Me methoxymethyl iPr 2,2,2-trifluoroethyl Index R3 f®R^ 508 2-methyl propanoyl Me methoxymethyl cyclopropyl 2,2,2-trifluoroethyl 509 2-methyl propanoyl Me acetyl cf3 2,2,2-trifluoroethyl 510 2-methyl propanoyl Me acetyl chf2 2,2,2-trifluoroethyl 511 2-methyl propanoyl Me acetyl iPr 2,2,2-trifluoroethyl 512 2-methyl propanoyl Me acetyl cyclopropyl 2,2,2-trifluoroethyl 513 H Cl H cf3 2,2-difluoroethyl 514 H Cl H chf2 2,2-difluoroethyl 515 H Cl H iPr 2,2-difluoroethyl 516 H Cl H cyclopropyl 2,2-difluoroethyl 517 H Cl methyl cf3 2,2-difluoroethyl 518 H Cl methyl chf2 2,2-difluoroethyl 519 H Cl methyl iPr 2,2-difluoroethyl 520 H Cl methyl cyclopropyl 2,2-difluoroethyl 521 H Cl methoxymethyl cf3 2,2-difluoroethyl 522 H Cl methoxymethyl chf2 2,2-difluoroethyl 523 H Cl methoxymethyl iPr 2,2-difluoroethyl 524 H Cl methoxymethyl cyclopropyl 2,2-difluoroethyl 525 H Cl acetyl cf3 2,2-difluoroethyl 526 H      ......... Cl acetyl chf2 2,2-difluoroethyl 527 H Cl acetyl iPr 2,2-difluoroethyl 528 H Cl acetyl cyclopropyl 2,2-difluoroethyl 529 H Me H cf3 2,2-difluoroethyl 530 H Me H chf2 2,2-difluoroethyl 531 H Me H iPr 2,2-difluoroethyl 532 H Me H cyclopropyl 2,2-difluoroethyl 533 H Me methyl cf3 2,2-difluoroethyl 534 H Me methyl chf2 2,2-difluoroethyl 535 H Me methyl iPr 2,2-difluoroethyl 536 H Me methyl cyclopropyl 2,2-difluoroethyl 537 H Me methoxymethyl cf3 2,2-difluoroethyl 538 H Me methoxymethyl CHF2 2,2-difluoroethyl 539 H Me methoxymethyl iPr 2,2-difluoroethyl 540 H Me methoxymethyl cyclopropyl 2,2-difluoroethyl 541 H Me acetyl cf3 2,2-difluoroethyl 542 H Me acetyl CHF2 2,2-difluoroethyl 543 H Me acetyl iPr 2,2-difluoroethyl 544 H Me acetyl cyclopropyl 2,2-difluoroethyl 545 methyl Cl H cf3 2,2-difluoroethyl 546 methyl Cl H chf2 2,2-difluoroethyl 547 methyl Cl H iPr 2,2-difluoroethyl 548 methyl Cl H cyclopropyl 2,2-difluoroethyl 549 methyl Cl methyl cf3 2,2-difluoroethyl 550 methyl Cl methyl chf2 2,2-difluoroethyl 551 methyl Cl methyl iPr 2,2-difluoroethyl 552 methyl Cl methyl cyclopropyl 2,2-difluoroethyl 553 methyl Cl methoxymethyl cf3 2,2-difluoroethyl Index R3 f®R^ ISIIIIIIIIIII 554 methyl ~    Cl methoxymethyl chf2 2,2-difluoroethyl 555 methyl Cl methoxymethyl iPr 2,2-difluoroethyl 556 methyl Cl methoxymethyl cyclopropyl 2,2-difluoroethyl 557 methyl Cl acetyl cf3 2,2-difluoroethyl 558 methyl Cl acetyl chf2 2,2-difluoroethyl 559 methyl Cl acetyl iPr 2,2-difluoroethyl 560 methyl Cl acetyl cyclopropyl 2,2-difluoroethyl 561 methyl Me H cf3 2,2-difluoroethyl 562 methyl Me H chf2 2,2-difluoroethyl 563 methyl Me H iPr 2,2-difluoroethyl 564 methyl Me H cyclopropyl 2,2-difluoroethyl 565 methyl Me methyl cf3 2,2-difluoroethyl 566 methyl Me methyl chf2 2,2-difluoroethyl 567 methyl Me methyl iPr 2,2-difluoroethyl 568 methyl Me methyl cyclopropyl 2,2-difluoroethyl 569 methyl Me methoxymethyl cf3 2,2-difluoroethyl 570 methyl Me methoxymethyl chf2 2,2-difluoroethyl 571 methyl Me methoxymethyl iPr 2,2-difluoroethyl 572 methyl Me methoxymethyl cyclopropyl 2,2-difluoroethyl 573 methyl Me acetyl cf3 2,2-difluoroethyl 574 methyl Me acetyl chf2 2,2-difluoroethyl 575 methyl Me acetyl iPr 2,2-difluoroethyl 576 methyl Me acetyl cyclopropyl 2,2-difluoroethyl 577 acetyl Cl H cf3 2,2-difluoroethyl 578 acetyl Cl H chf2 2,2-difluoroethyl 579 acetyl Cl H iPr 2,2-difluoroethyl 580 acetyl Cl H       ...... cyclopropyl 2,2-difluoroethyl 581 acetyl Cl methyl cf3 2,2-difluoroethyl 582 acetyl Cl methyl chf2 2,2-difluoroethyl 583 acetyl Cl methyl iPr 2,2-difluoroethyl 584 acetyl Cl methyl cyclopropyl 2,2-difluoroethyl 585 acetyl Cl methoxymethyl cf3 2,2-difluoroethyl 586 acetyl Cl methoxymethyl CHF2 2,2-difluoroethyl 587 acetyl Cl methoxymethyl iPr 2,2-difluoroethyl 588 acetyl Cl methoxymethyl cyclopropyl 2,2-difluoroethyl 589 acetyl Cl acetyl cf3 2,2-difluoroethyl 590 acetyl Cl acetyl chf2 2,2-difluoroethyl 591 acetyl Cl acetyl iPr 2,2-difluoroethyl 592 acetyl Cl acetyl cyclopropyl 2,2-difluoroethyl 593 acetyl Me H cf3 2,2-difluoroethyl 594 acetyl Me H chf2 2,2-difluoroethyl 595 acetyl Me H iPr 2,2-difluoroethyl 596 acetyl Me H cyclopropyl 2,2-difluoroethyl 597 acetyl Me methyl cf3 2,2-difluoroethyl 598 acetyl Me methyl chf2 2,2-difluoroethyl 599 acetyl Me methyl iPr 2,2-difluoroethyl Index R3 pBlililW 600 acetyl Me methyl cyclopropyl 2,2-difluoroethyl 601 acetyl Me methoxymethyl cf3 2,2-difluoroethyl 602 acetyl Me methoxymethyl chf2 2,2-difluoroethyl 603 acetyl Me methoxymethyl iPr 2,2-difluoroethyl 604 acetyl Me methoxymethyl cyclopropyl 2,2-difluoroethyl 605 acetyl Me acetyl cf3 2,2-difluoroethyl 606 acetyl Me acetyl chf2 2,2-difluoroethyl 607 acetyl Me acetyl iPr 2,2-difluoroethyl 608 acetyl Me acetyl cyclopropyl 2,2-difluoroethyl 609 2-methyl propanoyl Cl H cf3 2,2-difluoroethyl 610 2-methyl propanoyl Cl H chf2 2,2-difluoroethyl 611 2-methyl propanoyl Cl H iPr 2,2-difluoroethyl 612 2-methyl propanoyl Cl H cyclopropyl 2,2-difluoroethyl 613 2-methyl propanoyl Cl methyl cf3 2,2-difluoroethyl 614 2-methyl propanoyl Cl methyl chf2 2,2-difluoroethyl 615 2-methyl propanoyl Cl methyl iPr 2,2-difluoroethyl 616 2-methyl propanoyl Cl methyl cyclopropyl 2,2-difluoroethyl 617 2-methyl propanoyl Cl methoxymethyl cf3 2,2-difluoroethyl 618 2-methyl propanoyl Cl methoxymethyl chf2 2,2-difluoroethyl 619 2-methyl propanoyl Cl methoxymethyl iPr 2,2-difluoroethyl 620 2-methyl propanoyl Cl methoxymethyl cyclopropyl 2,2-difluoroethyl 621 2-methyl propanoyl Cl acetyl cf3 2,2-difluoroethyl 622 2-methyl propanoyl Cl acetyl chf2 2,2-difluoroethyl 623 2-methyl propanoyl Cl acetyl iPr 2,2-difluoroethyl 624 2-methyl propanoyl Cl acetyl cyclopropyl 2,2-difluoroethyl 625 2-methyl propanoyl Me H cf3 2,2-difluoroethyl 626 2-methyl propanoyl Me H       ...... chf2 2,2-difluoroethyl 627 2-methyl propanoyl Me H iPr 2,2-difluoroethyl 628 2-methyl propanoyl Me H cyclopropyl 2,2-difluoroethyl 629 2-methyl propanoyl Me methyl cf3 2,2-difluoroethyl 630 2-methyl propanoyl Me methyl CHF2 2,2-difluoroethyl 631 2-methyl propanoyl Me methyl iPr 2,2-difluoroethyl 632 2-methyl propanoyl Me methyl cyclopropyl 2,2-difluoroethyl 633 2-methyl propanoyl Me methoxymethyl cf3 2,2-difluoroethyl 634 2-methyl propanoyl Me methoxymethyl CHF2 2,2-difluoroethyl 635 2-methyl propanoyl Me methoxymethyl iPr 2,2-difluoroethyl 636 2-methyl propanoyl Me methoxymethyl cyclopropyl 2,2-difluoroethyl 637 2-methyl propanoyl Me acetyl cf3 2,2-difluoroethyl 638 2-methyl propanoyl Me acetyl chf2 2,2-difluoroethyl 639 2-methyl propanoyl Me acetyl iPr 2,2-difluoroethyl 640 2-methyl propanoyl Me acetyl cyclopropyl 2,2-difluoroethyl 641 H Cl H cf3 cyclopropyl 642 H Cl H chf2 cyclopropyl 643 H Cl H iPr cyclopropyl 644 H Cl H cyclopropyl cyclopropyl 645 H Cl methyl cf3 cyclopropyl Index piiiiiiiiii R3 R1 646 I H ~~~~ Cl methyl chf2 cyclopropyl 647 H Cl methyl iPr cyclopropyl 648 H Cl methyl cyclopropyl cyclopropyl 649 H Cl methoxymethyl cf3 cyclopropyl 650 H Cl methoxymethyl chf2 cyclopropyl 651 H Cl methoxymethyl iPr cyclopropyl 652 H Cl methoxymethyl cyclopropyl cyclopropyl 653 H Cl acetyl cf3 cyclopropyl 654 H Cl acetyl chf2 cyclopropyl 655 H Cl acetyl iPr cyclopropyl 656 H Cl acetyl cyclopropyl cyclopropyl 657 H Me H cf3 cyclopropyl 658 H Me H chf2 cyclopropyl 659 H Me H iPr cyclopropyl 660 H Me H cyclopropyl cyclopropyl 661 H Me methyl cf3 cyclopropyl 662 H Me methyl chf2 cyclopropyl 663 H Me methyl iPr cyclopropyl 664 H Me methyl cyclopropyl cyclopropyl 665 H Me methoxymethyl cf3 cyclopropyl 666 H Me methoxymethyl chf2 cyclopropyl 667 H Me methoxymethyl iPr cyclopropyl 668 H Me methoxymethyl cyclopropyl cyclopropyl 669 H Me acetyl cf3 cyclopropyl 670 H Me acetyl chf2 cyclopropyl 671 H Me acetyl iPr cyclopropyl 672 H Me acetyl cyclopropyl cyclopropyl 673 methyl Cl H cf3 cyclopropyl 674 methyl Cl H chf2 cyclopropyl 675 methyl Cl H iPr cyclopropyl 676 methyl Cl H cyclopropyl cyclopropyl 677 methyl Cl methyl cf3 cyclopropyl 678 methyl Cl methyl chf2 cyclopropyl 679 methyl Cl methyl iPr cyclopropyl 680 methyl Cl methyl cyclopropyl cyclopropyl 681 methyl Cl methoxymethyl cf3 cyclopropyl 682 methyl Cl methoxymethyl chf2 cyclopropyl 683 methyl Cl methoxymethyl iPr cyclopropyl 684 methyl Cl methoxymethyl cyclopropyl cyclopropyl 685 methyl Cl acetyl cf3 cyclopropyl 686 methyl Cl acetyl chf2 cyclopropyl 687 methyl Cl acetyl iPr cyclopropyl 688 methyl Cl acetyl cyclopropyl cyclopropyl 689 methyl Me H cf3 cyclopropyl 690 methyl Me H chf2 cyclopropyl 691 methyl Me H iPr cyclopropyl Index R3 R1 692 methyl Me H             " cyclopropyl cyclopropy 693 methyl Me methyl cf3 cyclopropy 694 methyl Me methyl chf2 cyclopropy 695 methyl Me methyl iPr cyclopropy 696 methyl Me methyl cyclopropyl cyclopropy 697 methyl Me methoxymethyl cf3 cyclopropy 698 methyl Me methoxymethyl chf2 cyclopropy 699 methyl Me methoxymethyl iPr cyclopropy 700 methyl Me methoxymethyl cyclopropyl cyclopropy 701 methyl Me acetyl cf3 cyclopropy 702 methyl Me acetyl chf2 cyclopropy 703 methyl Me acetyl iPr cyclopropy 704 methyl Me acetyl cyclopropyl cyclopropy 705 acetyl Cl H cf3 cyclopropy 706 acetyl Cl H chf2 cyclopropy 707 acetyl Cl H iPr cyclopropy 708 acetyl Cl H............. cyclopropyl cyclopropy 709 acetyl Cl methyl cf3 cyclopropy 710 acetyl Cl methyl chf2 cyclopropy 711 acetyl Cl methyl iPr cyclopropy 712 acetyl Cl methyl cyclopropyl cyclopropy 713 acetyl Cl methoxymethyl cf3 cyclopropy 714 acetyl d methoxymethyl chf2 cyclopropy 715 acetyl Cl methoxymethyl iPr cyclopropy 716 acetyl Cl methoxymethyl cyclopropyl cyclopropy 717 acetyl Cl acetyl cf3 cyclopropy 718 acetyl Cl acetyl chf2 cyclopropy 719 acetyl Cl acetyl iPr cyclopropy 720 acetyl Cl acetyl cyclopropyl cyclopropy 721 acetyl Me H cf3 cyclopropy 722 acetyl Me H CHF2 cyclopropy 723 acetyl Me H iPr cyclopropy 724 acetyl Me H cyclopropyl cyclopropy 725 acetyl Me methyl cf3 cyclopropy 726 acetyl Me methyl CHF2 cyclopropy 727 acetyl Me methyl iPr cyclopropy 728 acetyl Me methyl cyclopropyl cyclopropy 729 acetyl Me methoxymethyl cf3 cyclopropy 730 acetyl Me methoxymethyl chf2 cyclopropy 731 acetyl Me methoxymethyl iPr cyclopropy 732 acetyl Me methoxymethyl cyclopropyl cyclopropy 733 acetyl Me acetyl cf3 cyclopropy 734 acetyl Me acetyl chf2 cyclopropy 735 acetyl Me acetyl iPr cyclopropy 736 acetyl Me acetyl cyclopropyl cyclopropy 737 2-methyl propanoyl Cl H cf3 cyclopropy Index BIBBBBBIIIII / lli R3 738 2-methyl propanoyl Cl H chf2 cyclopropyl 739 2-methyl propanoyl Cl H iPr cyclopropyl 740 2-methyl propanoyl Cl H cyclopropyl cyclopropyl 741 2-methyl propanoyl Cl methyl cf3 cyclopropyl 742 2-methyl propanoyl Cl methyl chf2 cyclopropyl 743 2-methyl propanoyl Cl methyl iPr cyclopropyl 744 2-methyl propanoyl Cl methyl cyclopropyl cyclopropyl 745 2-methyl propanoyl Cl methoxymethyl cf3 cyclopropyl 746 2-methyl propanoyl Cl methoxymethyl chf2 cyclopropyl 747 2-methyl propanoyl Cl methoxymethyl iPr cyclopropyl 748 2-methyl propanoyl Cl methoxymethyl cyclopropyl cyclopropyl 749 2-methyl propanoyl Cl acetyl cf3 cyclopropyl 750 2-methyl propanoyl Cl acetyl chf2 cyclopropyl 751 2-methyl propanoyl Cl acetyl iPr cyclopropyl 752 2-methyl propanoyl Cl acetyl cyclopropyl cyclopropyl 753 2-methyl propanoyl Me H cf3 cyclopropyl 754 2-methyl propanoyl Me H chf2 cyclopropyl 755 2-methyl propanoyl Me H iPr cyclopropyl 756 2-methyl propanoyl Me H cyclopropyl cyclopropyl 757 2-methyl propanoyl Me methyl cf3 cyclopropyl 758 2-methyl propanoyl Me methyl chf2 cyclopropyl 759 2-methyl propanoyl Me methyl iPr cyclopropyl 760 2-methyl propanoyl Me methyl cyclopropyl cyclopropyl 761 2-methyl propanoyl Me methoxymethyl cf3 cyclopropyl 762 2-methyl propanoyl Me methoxymethyl chf2 cyclopropyl 763 2-methyl propanoyl Me methoxymethyl iPr cyclopropyl 764 2-methyl propanoyl Me methoxymethyl cyclopropyl cyclopropyl 765 2-methyl propanoyl Me acetyl cf3 cyclopropyl 766 2-methyl propanoyl Me acetyl chf2 cyclopropyl 767 2-methyl propanoyl Me acetyl iPr cyclopropyl 768 2-methyl propanoyl Me acetyl cyclopropyl cyclopropyl 769 H Cl H cf3 1-cyanocyclopropyl 770 H Cl H chf2 1-cyanocyclopropyl 771 H Cl H iPr 1-cyanocyclopropyl 772 H Cl H cyclopropyl 1-cyanocyclopropyl 773 H Cl methyl cf3 1-cyanocyclopropyl 774 H Cl methyl chf2 1-cyanocyclopropyl 775 H Cl methyl iPr 1-cyanocyclopropyl 776 H Cl methyl cyclopropyl 1-cyanocyclopropyl 777 H Cl methoxymethyl cf3 1-cyanocyclopropyl 778 H Cl methoxymethyl chf2 1-cyanocyclopropyl 779 H Cl methoxymethyl iPr 1-cyanocyclopropyl 780 H Cl methoxymethyl cyclopropyl 1-cyanocyclopropyl 781 H Cl acetyl cf3 1-cyanocyclopropyl 782 H Cl acetyl chf2 1-cyanocyclopropyl 783 H Cl acetyl iPr 1-cyanocyclopropyl Index R3 784 I H ~~~~ “    Cl acetyl cyclopropyl 1-cyanocyclopropy 785 H Me H cf3 1-cyanocyclopropy 786 H Me H      ...... chf2 1-cyanocyclopropy 787 H Me H iPr 1-cyanocyclopropy 788 H Me H cyclopropyl 1-cyanocyclopropy 789 H Me methyl cf3 1-cyanocyclopropy 790 H Me methyl chf2 1-cyanocyclopropy 791 H Me methyl iPr 1-cyanocyclopropy 792 H Me methyl cyclopropyl 1-cyanocyclopropy 793 H Me methoxymethyl cf3 1-cyanocyclopropy 794 H Me methoxymethyl chf2 1-cyanocyclopropy 795 H Me methoxymethyl iPr 1-cyanocyclopropy 796 H Me methoxymethyl cyclopropyl 1-cyanocyclopropy 797 H Me acetyl cf3 1-cyanocyclopropy 798 H Me acetyl chf2 1-cyanocyclopropy 799 H Me acetyl iPr 1-cyanocyclopropy 800 H Me acetyl cyclopropyl 1-cyanocyclopropy 801 methyl Cl H cf3 1-cyanocyclopropy 802 methyl Cl H chf2 1-cyanocyclopropy 803 methyl Cl H iPr 1-cyanocyclopropy 804 methyl Cl H cyclopropyl 1-cyanocyclopropy 805 methyl Cl methyl cf3 1-cyanocyclopropy 806 methyl d methyl chf2 1-cyanocyclopropy 807 methyl Cl methyl iPr 1-cyanocyclopropy 808 methyl Cl methyl cyclopropyl 1-cyanocyclopropy 809 methyl Cl methoxymethyl cf3 1-cyanocyclopropy 810 methyl Cl methoxymethyl chf2 1-cyanocyclopropy 811 methyl Cl methoxymethyl iPr 1-cyanocyclopropy 812 methyl Cl methoxymethyl cyclopropyl 1-cyanocyclopropy 813 methyl Cl acetyl cf3 1-cyanocyclopropy 814 methyl Cl acetyl CHF2 1-cyanocyclopropy 815 methyl Cl acetyl iPr 1-cyanocyclopropy 816 methyl Cl acetyl cyclopropyl 1-cyanocyclopropy 817 methyl Me H cf3 1-cyanocyclopropy 818 methyl Me H CHF2 1-cyanocyclopropy 819 methyl Me H iPr 1-cyanocyclopropy 820 methyl Me H cyclopropyl 1-cyanocyclopropy 821 methyl Me methyl cf3 1-cyanocyclopropy 822 methyl Me methyl chf2 1-cyanocyclopropy 823 methyl Me methyl iPr 1-cyanocyclopropy 824 methyl Me methyl cyclopropyl 1-cyanocyclopropy 825 methyl Me methoxymethyl cf3 1-cyanocyclopropy 826 methyl Me methoxymethyl chf2 1-cyanocyclopropy 827 methyl Me methoxymethyl iPr 1-cyanocyclopropy 828 methyl Me methoxymethyl cyclopropyl 1-cyanocyclopropy 829 methyl Me acetyl cf3 1-cyanocyclopropy Index R3 830 methyl Me acetyl chf2 1-cyanocyclopropy 831 methyl Me acetyl iPr 1-cyanocyclopropy 832 methyl Me acetyl cyclopropyl 1-cyanocyclopropy 833 acetyl Cl H cf3 1-cyanocyclopropy 834 acetyl Cl H chf2 1-cyanocyclopropy 835 acetyl Cl H iPr 1-cyanocyclopropy 836 acetyl Cl H cyclopropyl 1-cyanocyclopropy 837 acetyl Cl methyl cf3 1-cyanocyclopropy 838 acetyl Cl methyl chf2 1-cyanocyclopropy 839 acetyl Cl methyl iPr 1-cyanocyclopropy 840 acetyl Cl methyl cyclopropyl 1-cyanocyclopropy 841 acetyl Cl methoxymethyl cf3 1-cyanocyclopropy 842 acetyl Cl methoxymethyl chf2 1-cyanocyclopropy 843 acetyl Cl methoxymethyl iPr 1-cyanocyclopropy 844 acetyl Cl methoxymethyl cyclopropyl 1-cyanocyclopropy 845 acetyl Cl acetyl cf3 1-cyanocyclopropy 846 acetyl Cl acetyl chf2 1-cyanocyclopropy 847 acetyl Cl acetyl iPr 1-cyanocyclopropy 848 acetyl Cl acetyl cyclopropyl 1-cyanocyclopropy 849 acetyl Me H cf3 1-cyanocyclopropy 850 acetyl Me H chf2 1-cyanocyclopropy 851 acetyl Me H iPr 1-cyanocyclopropy 852 acetyl Me H cyclopropyl 1-cyanocyclopropy 853 acetyl Me methyl cf3 1-cyanocyclopropy 854 acetyl Me methyl chf2 1-cyanocyclopropy 855 acetyl Me methyl iPr 1-cyanocyclopropy 856 acetyl Me methyl cyclopropyl 1-cyanocyclopropy 857 acetyl Me methoxymethyl cf3 1-cyanocyclopropy 858 acetyl Me methoxymethyl chf2 1-cyanocyclopropy 859 acetyl Me methoxymethyl iPr 1-cyanocyclopropy 860 acetyl Me methoxymethyl cyclopropyl 1-cyanocyclopropy 861 acetyl Me acetyl cf3 1-cyanocyclopropy 862 acetyl Me acetyl CHF2 1-cyanocyclopropy 863 acetyl Me acetyl iPr 1-cyanocyclopropy 864 acetyl Me acetyl cyclopropyl 1-cyanocyclopropy 865 2-methyl propanoyl Cl H cf3 1-cyanocyclopropy 866 2-methyl propanoyl Cl H chf2 1-cyanocyclopropy 867 2-methyl propanoyl Cl H iPr 1-cyanocyclopropy 868 2-methyl propanoyl Cl H cyclopropyl 1-cyanocyclopropy 869 2-methyl propanoyl Cl methyl cf3 1-cyanocyclopropy 870 2-methyl propanoyl Cl methyl chf2 1-cyanocyclopropy 871 2-methyl propanoyl Cl methyl iPr 1-cyanocyclopropy 872 2-methyl propanoyl Cl methyl cyclopropyl 1-cyanocyclopropy 873 2-methyl propanoyl Cl methoxymethyl cf3 1-cyanocyclopropy 874 2-methyl propanoyl Cl methoxymethyl chf2 1-cyanocyclopropy 875 2-methyl propanoyl Cl methoxymethyl iPr 1-cyanocyclopropy Index R3 llgllllllllllll 876 2-methyl propanoyl Cl methoxymethyl cyclopropyl 1-cyanocyclopropyl 877 2-methyl propanoyl Cl acetyl cf3 1-cyanocyclopropyl 878 2-methyl propanoyl Cl acetyl chf2 1-cyanocyclopropyl 879 2-methyl propanoyl Cl acetyl iPr 1-cyanocyclopropyl 880 2-methyl propanoyl Cl acetyl cyclopropyl 1-cyanocyclopropyl 881 2-methyl propanoyl Me H cf3 1-cyanocyclopropyl 882 2-methyl propanoyl Me H chf2 1-cyanocyclopropyl 883 2-methyl propanoyl Me H iPr 1-cyanocyclopropyl 884 2-methyl propanoyl Me H cyclopropyl 1-cyanocyclopropyl 885 2-methyl propanoyl Me methyl cf3 1-cyanocyclopropyl 886 2-methyl propanoyl Me methyl chf2 1-cyanocyclopropyl 887 2-methyl propanoyl Me methyl iPr 1-cyanocyclopropyl 888 2-methyl propanoyl Me methyl cyclopropyl 1-cyanocyclopropyl 889 2-methyl propanoyl Me methoxymethyl cf3 1-cyanocyclopropyl 890 2-methyl propanoyl Me methoxymethyl chf2 1-cyanocyclopropyl 891 2-methyl propanoyl Me methoxymethyl iPr 1-cyanocyclopropyl 892 2-methyl propanoyl Me methoxymethyl cyclopropyl 1-cyanocyclopropyl 893 2-methyl propanoyl Me acetyl cf3 1-cyanocyclopropyl 894 2-methyl propanoyl Me acetyl chf2 1-cyanocyclopropyl 895 2-methyl propanoyl Me acetyl iPr 1-cyanocyclopropyl 896 2-methyl propanoyl Me acetyl cyclopropyl 1-cyanocyclopropyl 897 H Cl H cf3 1-cyanocyclobutyl 898 H Cl H chf2 1-cyanocyclobutyl 899 H Cl H iPr 1-cyanocyclobutyl 900 H Cl H cyclopropyl 1-cyanocyclobutyl 901 H Cl methyl cf3 1-cyanocyclobutyl 902 H Cl methyl chf2 1-cyanocyclobutyl 903 H Cl methyl iPr 1-cyanocyclobutyl 904 H Cl methyl cyclopropyl 1-cyanocyclobutyl 905 H Cl methoxymethyl cf3 1-cyanocyclobutyl 906 H Cl methoxymethyl chf2 1-cyanocyclobutyl 907 H Cl methoxymethyl iPr 1-cyanocyclobutyl 908 H Cl methoxymethyl cyclopropyl 1-cyanocyclobutyl 909 H Cl acetyl cf3 1-cyanocyclobutyl 910 H Cl acetyl chf2 1-cyanocyclobutyl 911 H Cl acetyl IPr 1-cyanocyclobutyl 912 H Cl acetyl cyclopropyl 1-cyanocyclobutyl 913 H Me H cf3 1-cyanocyclobutyl 914 H Me H chf2 1-cyanocyclobutyl 915 H Me H iPr 1-cyanocyclobutyl 916 H Me H cyclopropyl 1-cyanocyclobutyl 917 H Me methyl cf3 1-cyanocyclobutyl 918 H Me methyl chf2 1-cyanocyclobutyl 919 H Me methyl iPr 1-cyanocyclobutyl 920 H Me methyl cyclopropyl 1-cyanocyclobutyl 921 H Me methoxymethyl cf3 1-cyanocyclobutyl Index R3 922 I H ~~~~ Me methoxymethyl chf2 1-cyanocyclobuty 923 H Me methoxymethyl iPr 1-cyanocyclobuty 924 H Me methoxymethyl cyclopropyl 1-cyanocyclobuty 925 H Me acetyl cf3 1-cyanocyclobuty 926 H Me acetyl chf2 1-cyanocyclobuty 927 H Me acetyl iPr 1-cyanocyclobuty 928 H Me acetyl cyclopropyl 1-cyanocyclobuty 929 methyl Cl H cf3 1-cyanocyclobuty 930 methyl Cl H chf2 1-cyanocyclobuty 931 methyl Cl H iPr 1-cyanocyclobuty 932 methyl Cl H cyclopropyl 1-cyanocyclobuty 933 methyl Cl methyl cf3 1-cyanocyclobuty 934 methyl Cl methyl chf2 1-cyanocyclobuty 935 methyl Cl methyl iPr 1-cyanocyclobuty 936 methyl Cl methyl cyclopropyl 1-cyanocyclobuty 937 methyl Cl methoxymethyl cf3 1-cyanocyclobuty 938 methyl Cl methoxymethyl chf2 1-cyanocyclobuty 939 methyl Cl methoxymethyl iPr 1-cyanocyclobuty 940 methyl Cl methoxymethyl cyclopropyl 1-cyanocyclobuty 941 methyl Cl acetyl cf3 1-cyanocyclobuty 942 methyl Cl acetyl chf2 1-cyanocyclobuty 943 methyl Cl acetyl iPr 1-cyanocyclobuty 944 methyl d acetyl cyclopropyl 1-cyanocyclobuty 945 methyl Me H cf3 1-cyanocyclobuty 946 methyl Me H chf2 1-cyanocyclobuty 947 methyl Me H iPr 1-cyanocyclobuty 948 methyl Me H       ...... cyclopropyl 1-cyanocyclobuty 949 methyl Me methyl cf3 1-cyanocyclobuty 950 methyl Me methyl chf2 1-cyanocyclobuty 951 methyl Me methyl iPr 1-cyanocyclobuty 952 methyl Me methyl cyclopropyl 1-cyanocyclobuty 953 methyl Me methoxymethyl cf3 1-cyanocyclobuty 954 methyl Me methoxymethyl CHF2 1-cyanocyclobuty 955 methyl Me methoxymethyl iPr 1-cyanocyclobuty 956 methyl Me methoxymethyl cyclopropyl 1-cyanocyclobuty 957 methyl Me acetyl cf3 1-cyanocyclobuty 958 methyl Me acetyl chf2 1-cyanocyclobuty 959 methyl Me acetyl iPr 1-cyanocyclobuty 960 methyl Me acetyl cyclopropyl 1-cyanocyclobuty 961 acetyl Cl H cf3 1-cyanocyclobuty 962 acetyl Cl H chf2 1-cyanocyclobuty 963 acetyl Cl H iPr 1-cyanocyclobuty 964 acetyl Cl H cyclopropyl 1-cyanocyclobuty 965 acetyl Cl methyl cf3 1-cyanocyclobuty 966 acetyl Cl methyl chf2 1-cyanocyclobuty 967 acetyl Cl methyl iPr 1-cyanocyclobuty Index R3 ilSBBBBBIBBBIB 968 acetyl Cl methyl cyclopropyl 1-cyanocyclobutyl 969 acetyl Cl methoxymethyl cf3 1-cyanocyclobutyl 970 acetyl Cl methoxymethyl chf2 1-cyanocyclobutyl 971 acetyl Cl methoxymethyl iPr 1-cyanocyclobutyl 972 acetyl Cl methoxymethyl cyclopropyl 1-cyanocyclobutyl 973 acetyl Cl acetyl cf3 1-cyanocyclobutyl 974 acetyl Cl acetyl chf2 1-cyanocyclobutyl 975 acetyl Cl acetyl iPr 1-cyanocyclobutyl 976 acetyl Cl acetyl cyclopropyl 1-cyanocyclobutyl 977 acetyl Me H cf3 1-cyanocyclobutyl 978 acetyl Me H chf2 1-cyanocyclobutyl 979 acetyl Me H iPr 1-cyanocyclobutyl 980 acetyl Me H cyclopropyl 1-cyanocyclobutyl 981 acetyl Me methyl cf3 1-cyanocyclobutyl 982 acetyl Me methyl chf2 1-cyanocyclobutyl 983 acetyl Me methyl iPr 1-cyanocyclobutyl 984 acetyl Me methyl cyclopropyl 1-cyanocyclobutyl 985 acetyl Me methoxymethyl cf3 1-cyanocyclobutyl 986 acetyl Me methoxymethyl chf2 1-cyanocyclobutyl 987 acetyl Me methoxymethyl iPr 1-cyanocyclobutyl 988 acetyl Me methoxymethyl cyclopropyl 1-cyanocyclobutyl 989 acetyl Me acetyl cf3 1-cyanocyclobutyl 990 acetyl Me acetyl chf2 1-cyanocyclobutyl 991 acetyl Me acetyl iPr 1-cyanocyclobutyl 992 acetyl Me acetyl cyclopropyl 1-cyanocyclobutyl 993 2-methyl propanoyl Cl H cf3 1-cyanocyclobutyl 994 2-methyl propanoyl Cl H chf2 1-cyanocyclobutyl 995 2-methyl propanoyl Cl H iPr 1-cyanocyclobutyl 996 2-methyl propanoyl Cl H cyclopropyl 1-cyanocyclobutyl 997 2-methyl propanoyl Cl methyl cf3 1-cyanocyclobutyl 998 2-methyl propanoyl Cl methyl chf2 1-cyanocyclobutyl 999 2-methyl propanoyl Cl methyl iPr 1-cyanocyclobutyl 1000 2-methyl propanoyl Cl methyl cyclopropyl 1-cyanocyclobutyl 1001 2-methyl propanoyl Cl methoxymethyl cf3 1-cyanocyclobutyl 1002 2-methyl propanoyl Cl methoxymethyl chf2 1-cyanocyclobutyl 1003 2-methyl propanoyl Cl methoxymethyl iPr 1-cyanocyclobutyl 1004 2-methyl propanoyl Cl methoxymethyl cyclopropyl 1-cyanocyclobutyl 1005 2-methyl propanoyl Cl acetyl cf3 1-cyanocyclobutyl 1006 2-methyl propanoyl Cl acetyl chf2 1-cyanocyclobutyl 1007 2-methyl propanoyl Cl acetyl iPr 1-cyanocyclobutyl 1008 2-methyl propanoyl Cl acetyl cyclopropyl 1-cyanocyclobutyl 1009 2-methyl propanoyl Me H cf3 1-cyanocyclobutyl 1010 2-methyl propanoyl Me H chf2 1-cyanocyclobutyl 1011 2-methyl propanoyl Me H iPr 1-cyanocyclobutyl 1012 2-methyl propanoyl Me H cyclopropyl 1-cyanocyclobutyl 1013 2-methyl propanoyl Me methyl cf3 1-cyanocyclobutyl Index R3 f®R^ 1014 2-methyl propanoyl Me methyl chf2 1-cyanocyclobutyl 1015 2-methyl propanoyl Me methyl iPr 1-cyanocyclobutyl 1016 2-methyl propanoyl Me methyl cyclopropyl 1-cyanocyclobutyl 1017 2-methyl propanoyl Me methoxymethyl cf3 1-cyanocyclobutyl 1018 2-methyl propanoyl Me methoxymethyl chf2 1-cyanocyclobutyl 1019 2-methyl propanoyl Me methoxymethyl iPr 1-cyanocyclobutyl 1020 2-methyl propanoyl Me methoxymethyl cyclopropyl 1-cyanocyclobutyl 1021 2-methyl propanoyl Me acetyl cf3 1-cyanocyclobutyl 1022 2-methyl propanoyl Me acetyl chf2 1-cyanocyclobutyl 1023 2-methyl propanoyl Me acetyl iPr 1-cyanocyclobutyl 1024 2-methyl propanoyl Me acetyl cyclopropyl 1-cyanocyclobutyl 1025 H Cl H cf3 3,3-difluorocyclobutyl 1026 H Cl H chf2 3,3-difluorocyclobutyl 1027 H Cl H iPr 3,3-difluorocyclobutyl 1028 H Cl H cyclopropyl 3,3-difluorocyclobutyl 1029 H Cl methyl cf3 3,3-difluorocyclobutyl 1030 H Cl methyl chf2 3,3-difluorocyclobutyl 1031 H Cl methyl iPr 3,3-difluorocyclobutyl 1032 H Cl methyl cyclopropyl 3,3-difluorocyclobutyl 1033 H Cl methoxymethyl cf3 3,3-difluorocyclobutyl 1034 H Cl methoxymethyl chf2 3,3-difluorocyclobutyl 1035 H Cl methoxymethyl iPr 3,3-difluorocyclobutyl 1036 H Cl methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1037 H Cl acetyl cf3 3,3-difluorocyclobutyl 1038 H Cl acetyl chf2 3,3-difluorocyclobutyl 1039 H Cl acetyl iPr 3,3-difluorocyclobutyl 1040 H Cl acetyl cyclopropyl 3,3-difluorocyclobutyl 1041 H Me H cf3 3,3-difluorocyclobutyl 1042 H Me H chf2 3,3-difluorocyclobutyl 1043 H Me H iPr 3,3-difluorocyclobutyl 1044 H Me H cyclopropyl 3,3-difluorocyclobutyl 1045 H Me methyl cf3 3,3-difluorocyclobutyl 1046 H Me methyl chf2 3,3-difluorocyclobutyl 1047 H Me methyl iPr 3,3-difluorocyclobutyl 1048 H Me methyl cyclopropyl 3,3-difluorocyclobutyl 1049 H Me methoxymethyl cf3 3,3-difluorocyclobutyl 1050 H Me methoxymethyl chf2 3,3-difluorocyclobutyl 1051 H Me methoxymethyl iPr 3,3-difluorocyclobutyl 1052 H Me methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1053 H Me acetyl cf3 3,3-difluorocyclobutyl 1054 H Me acetyl chf2 3,3-difluorocyclobutyl 1055 H Me acetyl iPr 3,3-difluorocyclobutyl 1056 H Me acetyl cyclopropyl 3,3-difluorocyclobutyl 1057 methyl Cl H cf3 3,3-difluorocyclobutyl 1058 methyl Cl H chf2 3,3-difluorocyclobutyl 1059 methyl Cl H iPr 3,3-difluorocyclobutyl Index R3 (OlililW f®R^ llgllllllllllllll 1060 methyl Cl H cyclopropyl 3,3-difluorocyclobutyl 1061 methyl Cl methyl cf3 3,3-difluorocyclobutyl 1062 methyl Cl methyl chf2 3,3-difluorocyclobutyl 1063 methyl Cl methyl iPr 3,3-difluorocyclobutyl 1064 methyl Cl methyl cyclopropyl 3,3-difluorocyclobutyl 1065 methyl Cl methoxymethyl cf3 3,3-difluorocyclobutyl 1066 methyl Cl methoxymethyl chf2 3,3-difluorocyclobutyl 1067 methyl Cl methoxymethyl iPr 3,3-difluorocyclobutyl 1068 methyl Cl methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1069 methyl Cl acetyl cf3 3,3-difluorocyclobutyl 1070 methyl Cl acetyl chf2 3,3-difluorocyclobutyl 1071 methyl Cl acetyl iPr 3,3-difluorocyclobutyl 1072 methyl Cl acetyl cyclopropyl 3,3-difluorocyclobutyl 1073 methyl Me H cf3 3,3-difluorocyclobutyl 1074 methyl Me H chf2 3,3-difluorocyclobutyl 1075 methyl Me H iPr 3,3-difluorocyclobutyl 1076 methyl Me H cyclopropyl 3,3-difluorocyclobutyl 1077 methyl Me methyl cf3 3,3-difluorocyclobutyl 1078 methyl Me methyl chf2 3,3-difluorocyclobutyl 1079 methyl Me methyl iPr 3,3-difluorocyclobutyl 1080 methyl Me methyl cyclopropyl 3,3-difluorocyclobutyl 1081 methyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 1082 methyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 1083 methyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 1084 methyl Me methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1085 methyl Me acetyl cf3 3,3-difluorocyclobutyl 1086 methyl Me acetyl chf2 3,3-difluorocyclobutyl 1087 methyl Me acetyl iPr 3,3-difluorocyclobutyl 1088 methyl Me acetyl cyclopropyl 3,3-difluorocyclobutyl 1089 acetyl Cl H cf3 3,3-difluorocyclobutyl 1090 acetyl Cl H chf2 3,3-difluorocyclobutyl 1091 acetyl Cl H iPr 3,3-difluorocyclobutyl 1092 acetyl Cl H cyclopropyl 3,3-difluorocyclobutyl 1093 acetyl Cl methyl cf3 3,3-difluorocyclobutyl 1094 acetyl Cl methyl chf2 3,3-difluorocyclobutyl 1095 acetyl Cl methyl IPr 3,3-difluorocyclobutyl 1096 acetyl Cl methyl cyclopropyl 3,3-difluorocyclobutyl 1097 acetyl Cl methoxymethyl cf3 3,3-difluorocyclobutyl 1098 acetyl Cl methoxymethyl chf2 3,3-difluorocyclobutyl 1099 acetyl Cl methoxymethyl iPr 3,3-difluorocyclobutyl 1100 acetyl Cl methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1101 acetyl Cl acetyl cf3 3,3-difluorocyclobutyl 1102 acetyl Cl acetyl chf2 3,3-difluorocyclobutyl 1103 acetyl Cl acetyl iPr 3,3-difluorocyclobutyl 1104 acetyl Cl acetyl cyclopropyl 3,3-difluorocyclobutyl 1105 acetyl Me H cf3 3,3-difluorocyclobutyl Index plllllllllllllll R3 1106 acetyl Me H chf2 3,3-difluorocyclobutyl 1107 acetyl Me H iPr 3,3-difluorocyclobutyl 1108 acetyl Me H cyclopropyl 3,3-difluorocyclobutyl 1109 acetyl Me methyl cf3 3,3-difluorocyclobutyl 1110 acetyl Me methyl chf2 3,3-difluorocyclobutyl 1111 acetyl Me methyl iPr 3,3-difluorocyclobutyl 1112 acetyl Me methyl cyclopropyl 3,3-difluorocyclobutyl 1113 acetyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 1114 acetyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 1115 acetyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 1116 acetyl Me methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1117 acetyl Me acetyl cf3 3,3-difluorocyclobutyl 1118 acetyl Me acetyl chf2 3,3-difluorocyclobutyl 1119 acetyl Me acetyl iPr 3,3-difluorocyclobutyl 1120 acetyl Me acetyl cyclopropyl 3,3-difluorocyclobutyl 1121 2-methyl propanoyl Cl H cf3 3,3-difluorocyclobutyl 1122 2-methyl propanoyl Cl H chf2 3,3-difluorocyclobutyl 1123 2-methyl propanoyl Cl H iPr 3,3-difluorocyclobutyl 1124 2-methyl propanoyl Cl H cyclopropyl 3,3-difluorocyclobutyl 1125 2-methyl propanoyl Cl methyl cf3 3,3-difluorocyclobutyl 1126 2-methyl propanoyl Cl methyl chf2 3,3-difluorocyclobutyl 1127 2-methyl propanoyl Cl methyl iPr 3,3-difluorocyclobutyl 1128 2-methyl propanoyl Cl methyl cyclopropyl 3,3-difluorocyclobutyl 1129 2-methyl propanoyl Cl methoxymethyl cf3 3,3-difluorocyclobutyl 1130 2-methyl propanoyl Cl methoxymethyl chf2 3,3-difluorocyclobutyl 1131 2-methyl propanoyl Cl methoxymethyl iPr 3,3-difluorocyclobutyl 1132 2-methyl propanoyl ; Cl methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1133 2-methyl propanoyl Cl acetyl cf3 3,3-difluorocyclobutyl 1134 2-methyl propanoyl Cl acetyl chf2 3,3-difluorocyclobutyl 1135 2-methyl propanoyl Cl acetyl iPr 3,3-difluorocyclobutyl 1136 2-methyl propanoyl Cl acetyl cyclopropyl 3,3-difluorocyclobutyl 1137 2-methyl propanoyl Me H cf3 3,3-difluorocyclobutyl 1138 2-methyl propanoyl Me H chf2 3,3-difluorocyclobutyl 1139 2-methyl propanoyl Me H iPr 3,3-difluorocyclobutyl 1140 2-methyl propanoyl Me H cyclopropyl 3,3-difluorocyclobutyl 1141 2-methyl propanoyl Me methyl cf3 3,3-difluorocyclobutyl 1142 2-methyl propanoyl Me methyl chf2 3,3-difluorocyclobutyl 1143 2-methyl propanoyl Me methyl iPr 3,3-difluorocyclobutyl 1144 2-methyl propanoyl Me methyl cyclopropyl 3,3-difluorocyclobutyl 1145 2-methyl propanoyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 1146 2-methyl propanoyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 1147 2-methyl propanoyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 1148 2-methyl propanoyl Me methoxymethyl cyclopropyl 3,3-difluorocyclobutyl 1149 2-methyl propanoyl Me acetyl cf3 3,3-difluorocyclobutyl 1150 2-methyl propanoyl Me acetyl chf2 3,3-difluorocyclobutyl 1151 2-methyl propanoyl Me acetyl iPr 3,3-difluorocyclobutyl Index R3 1152 2-methyl propanoyl Me acetyl cyclopropyl 3,3-difluorocyclobutyl 1153 H Cl H cf3 1,1-dioxothietan-3-yl 1154 H Cl H      ...... chf2 1,1-dioxothietan-3-yl 1155 H Cl H iPr 1,1-dioxothietan-3-yl 1156 H Cl H cyclopropyl 1,1-dioxothietan-3-yl 1157 H Cl methyl cf3 1,1-dioxothietan-3-yl 1158 H Cl methyl chf2 1,1-dioxothietan-3-yl 1159 H Cl methyl iPr 1,1-dioxothietan-3-yl 1160 H Cl methyl cyclopropyl 1,1-dioxothietan-3-yl 1161 H Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 1162 H Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 1163 H Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 1164 H Cl methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1165 H Cl acetyl cf3 1,1-dioxothietan-3-yl 1166 H Cl acetyl chf2 1,1-dioxothietan-3-yl 1167 H Cl acetyl iPr 1,1-dioxothietan-3-yl 1168 H Cl acetyl cyclopropyl 1,1-dioxothietan-3-yl 1169 H Me H cf3 1,1-dioxothietan-3-yl 1170 H      ......... Me H chf2 1,1-dioxothietan-3-yl 1171 H Me H iPr 1,1-dioxothietan-3-yl 1172 H Me H cyclopropyl 1,1-dioxothietan-3-yl 1173 H Me methyl cf3 1,1-dioxothietan-3-yl 1174 H Me methyl chf2 1,1-dioxothietan-3-yl 1175 H Me methyl iPr 1,1-dioxothietan-3-yl 1176 H Me methyl cyclopropyl 1,1-dioxothietan-3-yl 1177 H Me methoxymethyl cf3 1,1-dioxothietan-3-yl 1178 H Me methoxymethyl chf2 1,1-dioxothietan-3-yl 1179 H Me methoxymethyl iPr 1,1-dioxothietan-3-yl 1180 H Me methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1181 H Me acetyl cf3 1,1-dioxothietan-3-yl 1182 H Me acetyl CHF2 1,1-dioxothietan-3-yl 1183 H Me acetyl iPr 1,1-dioxothietan-3-yl 1184 H Me acetyl cyclopropyl 1,1-dioxothietan-3-yl 1185 methyl Cl H cf3 1,1-dioxothietan-3-yl 1186 methyl Cl H CHF2 1,1 -dioxothietan-3-yl 1187 methyl Cl H iPr 1,1-dioxothietan-3-yl 1188 methyl Cl H cyclopropyl 1,1-dioxothietan-3-yl 1189 methyl Cl methyl cf3 1,1-dioxothietan-3-yl 1190 methyl Cl methyl chf2 1,1-dioxothietan-3-yl 1191 methyl Cl methyl iPr 1,1-dioxothietan-3-yl 1192 methyl Cl methyl cyclopropyl 1,1-dioxothietan-3-yl 1193 methyl Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 1194 methyl Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 1195 methyl Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 1196 methyl Cl methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1197 methyl Cl acetyl cf3 1,1-dioxothietan-3-yl Index R3 pBlililW 1198 methyl ~     Cl acetyl chf2 1,1-dioxothietan-3-yl 1199 methyl Cl acetyl iPr 1,1-dioxothietan-3-yl 1200 methyl Cl acetyl cyclopropyl 1,1-dioxothietan-3-yl 1201 methyl Me H cf3 1,1-dioxothietan-3-yl 1202 methyl Me H chf2 1,1-dioxothietan-3-yl 1203 methyl Me H iPr 1,1-dioxothietan-3-yl 1204 methyl Me H cyclopropyl 1,1-dioxothietan-3-yl 1205 methyl Me methyl cf3 1,1-dioxothietan-3-yl 1206 methyl Me methyl chf2 1,1-dioxothietan-3-yl 1207 methyl Me methyl iPr 1,1-dioxothietan-3-yl 1208 methyl Me methyl cyclopropyl 1,1-dioxothietan-3-yl 1209 methyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 1210 methyl Me methoxymethyl chf2 1,1-dioxothietan-3-yl 1211 methyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl 1212 methyl Me methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1213 methyl Me acetyl cf3 1,1-dioxothietan-3-yl 1214 methyl Me acetyl chf2 1,1-dioxothietan-3-yl 1215 methyl Me acetyl iPr 1,1-dioxothietan-3-yl 1216 methyl Me acetyl cyclopropyl 1,1-dioxothietan-3-yl 1217 acetyl Cl H cf3 1,1-dioxothietan-3-yl 1218 acetyl Cl H chf2 1,1-dioxothietan-3-yl 1219 acetyl Cl H iPr 1,1-dioxothietan-3-yl 1220 acetyl d H cyclopropyl 1,1-dioxothietan-3-yl 1221 acetyl Cl methyl cf3 1,1-dioxothietan-3-yl 1222 acetyl Cl methyl chf2 1,1-dioxothietan-3-yl 1223 acetyl Cl methyl iPr 1,1-dioxothietan-3-yl 1224 acetyl Cl methyl cyclopropyl 1,1-dioxothietan-3-yl 1225 acetyl Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 1226 acetyl Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 1227 acetyl Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 1228 acetyl Cl methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1229 acetyl Cl acetyl cf3 1,1-dioxothietan-3-yl 1230 acetyl Cl acetyl CHF2 1,1-dioxothietan-3-yl 1231 acetyl Cl acetyl iPr 1,1-dioxothietan-3-yl 1232 acetyl Cl acetyl cyclopropyl 1,1 -dioxothietan-3-yl 1233 acetyl Me H cf3 1,1-dioxothietan-3-yl 1234 acetyl Me H chf2 1,1-dioxothietan-3-yl 1235 acetyl Me H iPr 1,1-dioxothietan-3-yl 1236 acetyl Me H cyclopropyl 1,1-dioxothietan-3-yl 1237 acetyl Me methyl cf3 1,1-dioxothietan-3-yl 1238 acetyl Me methyl chf2 1,1-dioxothietan-3-yl 1239 acetyl Me methyl iPr 1,1-dioxothietan-3-yl 1240 acetyl Me methyl cyclopropyl 1,1-dioxothietan-3-yl 1241 acetyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 1242 acetyl Me methoxymethyl chf2 1,1-dioxothietan-3-yl 1243 acetyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl Index R3 pBlililW 1244 acetyl Me methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1245 acetyl Me acetyl cf3 1,1-dioxothietan-3-yl 1246 acetyl Me acetyl chf2 1,1-dioxothietan-3-yl 1247 acetyl Me acetyl iPr 1,1-dioxothietan-3-yl 1248 acetyl Me acetyl cyclopropyl 1,1-dioxothietan-3-yl 1249 2-methyl propanoyl Cl H cf3 1,1-dioxothietan-3-yl 1250 2-methyl propanoyl Cl H chf2 1,1-dioxothietan-3-yl 1251 2-methyl propanoyl Cl H iPr 1,1-dioxothietan-3-yl 1252 2-methyl propanoyl Cl H cyclopropyl 1,1-dioxothietan-3-yl 1253 2-methyl propanoyl Cl methyl cf3 1,1-dioxothietan-3-yl 1254 2-methyl propanoyl Cl methyl chf2 1,1-dioxothietan-3-yl 1255 2-methyl propanoyl Cl methyl iPr 1,1-dioxothietan-3-yl 1256 2-methyl propanoyl Cl methyl cyclopropyl 1,1-dioxothietan-3-yl 1257 2-methyl propanoyl Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 1258 2-methyl propanoyl Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 1259 2-methyl propanoyl Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 1260 2-methyl propanoyl Cl methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1261 2-methyl propanoyl Cl acetyl cf3 1,1-dioxothietan-3-yl 1262 2-methyl propanoyl Cl acetyl chf2 1,1-dioxothietan-3-yl 1263 2-methyl propanoyl Cl acetyl iPr 1,1-dioxothietan-3-yl 1264 2-methyl propanoyl Cl acetyl cyclopropyl 1,1-dioxothietan-3-yl 1265 2-methyl propanoyl Me H cf3 1,1-dioxothietan-3-yl 1266 2-methyl propanoyl Me H chf2 1,1-dioxothietan-3-yl 1267 2-methyl propanoyl Me H iPr 1,1-dioxothietan-3-yl 1268 2-methyl propanoyl Me H cyclopropyl 1,1-dioxothietan-3-yl 1269 2-methyl propanoyl Me methyl cf3 1,1-dioxothietan-3-yl 1270 2-methyl propanoyl Me methyl chf2 1,1-dioxothietan-3-yl 1271 2-methyl propanoyl Me methyl iPr 1,1-dioxothietan-3-yl 1272 2-methyl propanoyl Me methyl cyclopropyl 1,1-dioxothietan-3-yl 1273 2-methyl propanoyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 1274 2-methyl propanoyl Me methoxymethyl CHF2 1,1-dioxothietan-3-yl 1275 2-methyl propanoyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl 1276 2-methyl propanoyl Me methoxymethyl cyclopropyl 1,1-dioxothietan-3-yl 1277 2-methyl propanoyl Me acetyl cf3 1,1-dioxothietan-3-yl 1278 2-methyl propanoyl Me acetyl CHF2 1,1 -dioxothietan-3-yl 1279 2-methyl propanoyl Me acetyl iPr 1,1-dioxothietan-3-yl 1280 2-methyl propanoyl Me acetyl cyclopropyl 1,1-dioxothietan-3-yl 1281 H Cl H cf3 cyclopropylmethyl 1282 H Cl H chf2 cyclopropylmethyl 1283 H Cl H iPr cyclopropylmethyl 1284 H Cl H cyclopropyl cyclopropylmethyl 1285 H Cl methyl cf3 cyclopropylmethyl 1286 H Cl methyl chf2 cyclopropylmethyl 1287 H Cl methyl iPr cyclopropylmethyl 1288 H Cl methyl cyclopropyl cyclopropylmethyl 1289 H Cl methoxymethyl cf3 cyclopropylmethyl Index R3 pBlililW 1290 ? H —— ~     Cl methoxymethyl chf2 cyclopropylmethy 1291 H Cl methoxymethyl iPr cyclopropylmethy 1292 H Cl methoxymethyl cyclopropyl cyclopropylmethy 1293 H Cl acetyl cf3 cyclopropylmethy 1294 H Cl acetyl chf2 cyclopropylmethy 1295 H Cl acetyl iPr cyclopropylmethy 1296 H Cl acetyl cyclopropyl cyclopropylmethy 1297 H Me H cf3 cyclopropylmethy 1298 H Me H chf2 cyclopropylmethy 1299 H Me H iPr cyclopropylmethy 1300 H Me H cyclopropyl cyclopropylmethy 1301 H Me methyl cf3 cyclopropylmethy 1302 H Me methyl chf2 cyclopropylmethy 1303 H Me methyl iPr cyclopropylmethy 1304 H Me methyl cyclopropyl cyclopropylmethy 1305 H Me methoxymethyl cf3 cyclopropylmethy 1306 H Me methoxymethyl chf2 cyclopropylmethy 1307 H Me methoxymethyl iPr cyclopropylmethy 1308 H      ......... Me methoxymethyl cyclopropyl cyclopropylmethy 1309 H Me acetyl cf3 cyclopropylmethy 1310 H Me acetyl chf2 cyclopropylmethy 1311 H Me acetyl iPr cyclopropylmethy 1312 H Me acetyl cyclopropyl cyclopropylmethy 1313 methyl Cl H cf3 cyclopropylmethy 1314 methyl Cl H chf2 cyclopropylmethy 1315 methyl Cl H iPr cyclopropylmethy 1316 methyl Cl H       ...... cyclopropyl cyclopropylmethy 1317 methyl Cl methyl cf3 cyclopropylmethy 1318 methyl Cl methyl chf2 cyclopropylmethy 1319 methyl Cl methyl iPr cyclopropylmethy 1320 methyl Cl methyl cyclopropyl cyclopropylmethy 1321 methyl Cl methoxymethyl cf3 cyclopropylmethy 1322 methyl Cl methoxymethyl CHF2 cyclopropylmethy 1323 methyl Cl methoxymethyl iPr cyclopropylmethy 1324 methyl Cl methoxymethyl cyclopropyl cyclopropylmethy 1325 methyl Cl acetyl cf3 cyclopropylmethy 1326 methyl Cl acetyl chf2 cyclopropylmethy 1327 methyl Cl acetyl iPr cyclopropylmethy 1328 methyl Cl acetyl cyclopropyl cyclopropylmethy 1329 methyl Me H cf3 cyclopropylmethy 1330 methyl Me H chf2 cyclopropylmethy 1331 methyl Me H iPr cyclopropylmethy 1332 methyl Me H cyclopropyl cyclopropylmethy 1333 methyl Me methyl cf3 cyclopropylmethy 1334 methyl Me methyl chf2 cyclopropylmethy 1335 methyl Me methyl iPr cyclopropylmethy Index R3 pBlililW 1336 methyl Me methyl cyclopropyl cyclopropylmethy 1337 methyl Me methoxymethyl cf3 cyclopropylmethy 1338 methyl Me methoxymethyl chf2 cyclopropylmethy 1339 methyl Me methoxymethyl iPr cyclopropylmethy 1340 methyl Me methoxymethyl cyclopropyl cyclopropylmethy 1341 methyl Me acetyl cf3 cyclopropylmethy 1342 methyl Me acetyl chf2 cyclopropylmethy 1343 methyl Me acetyl iPr cyclopropylmethy 1344 methyl Me acetyl cyclopropyl cyclopropylmethy 1345 acetyl Cl H cf3 cyclopropylmethy 1346 acetyl Cl H chf2 cyclopropylmethy 1347 acetyl Cl H iPr cyclopropylmethy 1348 acetyl Cl H cyclopropyl cyclopropylmethy 1349 acetyl Cl methyl cf3 cyclopropylmethy 1350 acetyl Cl methyl chf2 cyclopropylmethy 1351 acetyl Cl methyl iPr cyclopropylmethy 1352 acetyl Cl methyl cyclopropyl cyclopropylmethy 1353 acetyl Cl methoxymethyl cf3 cyclopropylmethy 1354 acetyl Cl methoxymethyl chf2 cyclopropylmethy 1355 acetyl Cl methoxymethyl iPr cyclopropylmethy 1356 acetyl Cl methoxymethyl cyclopropyl cyclopropylmethy 1357 acetyl Cl acetyl cf3 cyclopropylmethy 1358 acetyl Cl acetyl chf2 cyclopropylmethy 1359 acetyl Cl acetyl iPr cyclopropylmethy 1360 acetyl Cl acetyl cyclopropyl cyclopropylmethy 1361 acetyl Me H cf3 cyclopropylmethy 1362 acetyl Me H       ...... chf2 cyclopropylmethy 1363 acetyl Me H iPr cyclopropylmethy 1364 acetyl Me H cyclopropyl cyclopropylmethy 1365 acetyl Me methyl cf3 cyclopropylmethy 1366 acetyl Me methyl CHF2 cyclopropylmethy 1367 acetyl Me methyl iPr cyclopropylmethy 1368 acetyl Me methyl cyclopropyl cyclopropylmethy 1369 acetyl Me methoxymethyl cf3 cyclopropylmethy 1370 acetyl Me methoxymethyl CHF2 cyclopropylmethy 1371 acetyl Me methoxymethyl iPr cyclopropylmethy 1372 acetyl Me methoxymethyl cyclopropyl cyclopropylmethy 1373 acetyl Me acetyl cf3 cyclopropylmethy 1374 acetyl Me acetyl chf2 cyclopropylmethy 1375 acetyl Me acetyl iPr cyclopropylmethy 1376 acetyl Me acetyl cyclopropyl cyclopropylmethy 1377 2-methyl propanoyl Cl H cf3 cyclopropylmethy 1378 2-methyl propanoyl Cl H chf2 cyclopropylmethy 1379 2-methyl propanoyl Cl H iPr cyclopropylmethy 1380 2-methyl propanoyl Cl H cyclopropyl cyclopropylmethy 1381 2-methyl propanoyl Cl methyl cf3 cyclopropylmethy Index R3 pBlililW R7 1382 2-methyl propanoyl Cl methyl chf2 cyclopropylmethyl 1383 2-methyl propanoyl Cl methyl iPr cyclopropylmethyl 1384 2-methyl propanoyl Cl methyl cyclopropyl cyclopropylmethyl 1385 2-methyl propanoyl Cl methoxymethyl cf3 cyclopropylmethyl 1386 2-methyl propanoyl Cl methoxymethyl chf2 cyclopropylmethyl 1387 2-methyl propanoyl Cl methoxymethyl iPr cyclopropylmethyl 1388 2-methyl propanoyl Cl methoxymethyl cyclopropyl cyclopropylmethyl 1389 2-methyl propanoyl Cl acetyl cf3 cyclopropylmethyl 1390 2-methyl propanoyl Cl acetyl chf2 cyclopropylmethyl 1391 2-methyl propanoyl Cl acetyl iPr cyclopropylmethyl 1392 2-methyl propanoyl Cl acetyl cyclopropyl cyclopropylmethyl 1393 2-methyl propanoyl Me H cf3 cyclopropylmethyl 1394 2-methyl propanoyl Me H chf2 cyclopropylmethyl 1395 2-methyl propanoyl Me H iPr cyclopropylmethyl 1396 2-methyl propanoyl Me H cyclopropyl cyclopropylmethyl 1397 2-methyl propanoyl Me methyl cf3 cyclopropylmethyl 1398 2-methyl propanoyl Me methyl chf2 cyclopropylmethyl 1399 2-methyl propanoyl Me methyl iPr cyclopropylmethyl 1400 2-methyl propanoyl Me methyl cyclopropyl cyclopropylmethyl 1401 2-methyl propanoyl Me methoxymethyl cf3 cyclopropylmethyl 1402 2-methyl propanoyl Me methoxymethyl chf2 cyclopropylmethyl 1403 2-methyl propanoyl Me methoxymethyl iPr cyclopropylmethyl 1404 2-methyl propanoyl Me methoxymethyl cyclopropyl cyclopropylmethyl 1405 2-methyl propanoyl Me acetyl cf3 cyclopropylmethyl 1406 2-methyl propanoyl Me acetyl chf2 cyclopropylmethyl 1407 2-methyl propanoyl Me acetyl iPr cyclopropylmethyl 1408 2-methyl propanoyl Me acetyl cyclopropyl cyclopropylmethyl 1409 H Cl H chci2 cyclopropyl 1410 H Cl H cf3 bicyclo[1.1,1]pentanyl 1411 H Cl tert-butoxy carbonyl cf3 1-cyanocyclopropyl 1412 H Cl cyanomethyl cf3 1-cyanocyclopropyl 1413 H Cl 2- methylpropanoyloxy methyl cf3 1-cyanocyclopropyl 1414 H Cl H cf3 tert-butyl 1415 H Cl 2- methylpropanoyloxy methyl cf3 cyclopropyl 1416 H Cl methoxy carbonyl cf3 cyclopropyl 1417 H Cl cyanomethyl cf3 cyclopropyl 1418 H Cl H cf3 5-fluoro 3-cyano pyridin-6-yl 1419 H Cl H cf3 5-fluoro 3-chloro pyridin-6-yl 1420 H Cl H cf3 5-methyl 3-chloro pyridin-6-yl 1421 H Cl H cf3 2,4,6-trifluoro phenyl 1422 H Cl H cf3 2,4-difluoro phenyl 1423 H Cl H cf3 2-fluoro 4-cyano phenyl Index R2 R3 R7 1424 H Cl H cf3 2-fluoro 4-(methylsulfonyl) phenyl 1425 H Cl H cf3 2-fluoro 4-chloro phenyl 1426 H Me H ^F3 bicyclo[1.1,1]pentanyl 1427 H Me H cf3 1-[2-(5-cyano-2-pyridyl)-1,2,4-triazol-3-yl]ethyl 1428 H Me H cf3 (5-chloro-2-pyridyl)methyl 1429 H Me H cf3 (1E)-1-methoxyimino-2-methyl-propan-2-yl 1430 H Me H cf3 3-oxo-2-(2,2,2- trifluoroethyl)isoxazolidine-4-yl 1431 H Me H cf3 1-cyclopropyl ethyl 1432 H Me H cf3 (3-chloro-2-pyridyl) methyl 1433 H Me H cf3 2,4-difluoro phenyl 1434 H Me H cf3 1-(4-fluorophenyl)-2-oxo-pyrrolidine-3-yl 1435 H Me H cf3 1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl 1436 H Me H cf3 cyclopropyl methoxy 1437 H Cl tert-butoxy carbonyl cf3 cyclopropyl 1438 H Cl H cf3 benzyl 1439 H Cl H cf3 1-cyclopropyl ethyl 1440 H Cl H cf3 1-cyanocyclopropyl methyl 1441 H Cl H cf3 3-oxo-2-ethyl isoxazolidine-4-yl 1442 H Cl H cf3 3-oxo-2-(2,2,2- trifluoroethyl)isoxazolidine-4-yl 1443 H Cl H cf3 3-methyltetrahydrofuran-3-yl 1444 H Cl H cf3 2-cyclopropylmethylamino-2-oxo ethyl 1445 H Cl H cf3 phenyl 1446 H Cl H cf3 1-methyl 1-cyano ethyl 1447 H Cl H cf3 2-methyl 4-fluoro phenyl Table 2: Makes available 396 compounds of the formula (l-2a), where the substituents R1, R2’ R3, R6 and R7 are designated in each row below: Index R2 R3 R® R7 R1 1 H Cl H cf3 ethyl 2 H Cl H chf2 ethyl 3 H Cl H iPr ethyl 4 H Cl methoxymethyl cf3 ethyl 5 H Cl methoxymethyl chf2 ethyl 6 H Cl methoxymethyl iPr ethyl 7 H Me H cf3 ethyl 8 H Me H chf2 ethyl 9 H Me H iPr ethyl 10 H Me methoxymethyl cf3 ethyl 11 H Me methoxymethyl chf2 ethyl 12 H Me methoxymethyl iPr ethyl Index R3 R7 R1 13 i H         ..................... CN ! H ~~——~~ cf3 ethyl 14 H CN H chf2 ethyl 15 H CN H iPr ethyl 16 H CN methoxymethyl cf3 ethyl 17 H CN methoxymethyl chf2 ethyl 18 H CN methoxymethyl iPr ethyl 19 methyl Cl H cf3 ethyl 20 methyl Cl H chf2 ethyl 21 methyl Cl H iPr ethyl 22 methyl Cl methoxymethyl cf3 ethyl 23 methyl Cl methoxymethyl chf2 ethyl 24 methyl Cl methoxymethyl iPr ethyl 25 methyl Me H cf3 ethyl 26 methyl Me H chf2 ethyl 27 methyl Me H iPr ethyl 28 methyl Me methoxymethyl cf3 ethyl 29 methyl Me methoxymethyl chf2 ethyl 30 methyl Me methoxymethyl iPr ethyl 31 methyl CN H cf3 ethyl 32 methyl CN H chf2 ethyl 33 methyl CN H iPr ethyl 34 methyl CN methoxymethyl cf3 ethyl 35 methyl CN methoxymethyl chf2 ethyl 36 methyl CN methoxymethyl iPr ethyl 37 H Cl H cf3 isopropyl 38 H Cl H chf2 isopropyl 39 H Cl H iPr isopropyl 40 H Cl methoxymethyl cf3 isopropyl 41 H Cl methoxymethyl chf2 isopropyl 42 H Cl methoxymethyl iPr isopropyl 43 H Me H cf3 isopropyl 44 H Me H chf2 isopropyl 45 H Me H iPr isopropyl 46 H Me methoxymethyl cf3 isopropyl 47 H Me methoxymethyl chf2 isopropyl 48 H Me methoxymethyl iPr isopropyl 49 H CN H cf3 isopropyl 50 H CN H chf2 isopropyl 51 H CN H iPr isopropyl 52 H CN methoxymethyl cf3 isopropyl 53 H CN methoxymethyl chf2 isopropyl 54 H CN methoxymethyl iPr isopropyl 55 methyl Cl H cf3 isopropyl 56 methyl Cl H chf2 isopropyl 57 methyl Cl H iPr isopropyl 58 methyl Cl methoxymethyl cf3 isopropyl Index R3 [111 / / / / / / / / / / R7 R1 59 methyl methoxymethyl chf2 isopropyl 60 methyl Cl methoxymethyl iPr isopropyl 61 methyl Me H cf3 isopropyl 62 methyl Me H chf2 isopropyl 63 methyl Me H......... iPr isopropyl 64 methyl Me methoxymethyl cf3 isopropyl 65 methyl Me methoxymethyl chf2 isopropyl 66 methyl Me methoxymethyl iPr isopropyl 67 methyl CN H cf3 isopropyl 68 methyl CN H chf2 isopropyl 69 methyl CN H iPr isopropyl 70 methyl CN methoxymethyl cf3 isopropyl 71 methyl CN methoxymethyl chf2 isopropyl 72 methyl CN methoxymethyl iPr isopropyl 73 H Cl H cf3 propargy 74 H Cl H chf2 propargy 75 H Cl H iPr propargy 76 H Cl methoxymethyl cf3 propargy 77 H Cl methoxymethyl chf2 propargy 78 H Cl methoxymethyl iPr propargy 79 H Me H cf3 propargy 80 H Me H chf2 propargy 81 H Me H iPr propargy 82 H Me methoxymethyl cf3 propargy 83 H Me methoxymethyl chf2 propargy 84 H Me methoxymethyl iPr propargy 85 H CN H cf3 propargy 86 H CN H chf2 propargy 87 H CN H iPr propargy 88 H CN methoxymethyl cf3 propargy 89 H CN methoxymethyl chf2 propargy 90 H CN methoxymethyl iPr propargy 91 methyl Cl H cf3 propargy 92 methyl Cl H chf2 propargy 93 methyl Cl H iPr propargy 94 methyl Cl methoxymethyl cf3 propargy 95 methyl Cl methoxymethyl chf2 propargy 96 methyl Cl methoxymethyl iPr propargy 97 methyl Me H cf3 propargy 98 methyl Me H chf2 propargy 99 methyl Me H ..... iPr propargy 100 methyl Me methoxymethyl cf3 propargy 101 methyl Me methoxymethyl chf2 propargy 102 methyl Me methoxymethyl iPr propargy 103 methyl CN H cf3 propargy 104 methyl CN H chf2 propargy Index R3 R7 R1 105 methyl CN ! H ~~——~~ iPr propargyl 106 methyl CN methoxymethyl cf3 propargyl 107 methyl CN methoxymethyl CHF2 propargyl 108 methyl CN methoxymethyl iPr propargyl 109 H Cl H......... cf3 2,2,2-trifluoroethyl 110 H Cl H chf2 2,2,2-trifluoroethyl 111 H Cl H iPr 2,2,2-trifluoroethyl 112 H Cl methoxymethyl cf3 2,2,2-trifluoroethyl 113 H Cl methoxymethyl chf2 2,2,2-trifluoroethyl 114 H Cl methoxymethyl iPr 2,2,2-trifluoroethyl 115 H Me H cf3 2,2,2-trifluoroethyl 116 H Me H chf2 2,2,2-trifluoroethyl 117 H Me H iPr 2,2,2-trifluoroethyl 118 H Me methoxymethyl cf3 2,2,2-trifluoroethyl 119 H Me methoxymethyl chf2 2,2,2-trifluoroethyl 120 H Me methoxymethyl iPr 2,2,2-trifluoroethyl 121 H CN H cf3 2,2,2-trifluoroethyl 122 H CN H chf2 2,2,2-trifluoroethyl 123 H CN H iPr 2,2,2-trifluoroethyl 124 H CN methoxymethyl cf3 2,2,2-trifluoroethyl 125 H CN methoxymethyl chf2 2,2,2-trifluoroethyl 126 H CN methoxymethyl iPr 2,2,2-trifluoroethyl 127 methyl Cl H cf3 2,2,2-trifluoroethyl 128 methyl Cl H chf2 2,2,2-trifluoroethyl 129 methyl Cl H iPr 2,2,2-trifluoroethyl 130 methyl Cl methoxymethyl cf3 2,2,2-trifluoroethyl 131 methyl Cl methoxymethyl chf2 2,2,2-trifluoroethyl 132 methyl Cl methoxymethyl iPr 2,2,2-trifluoroethyl 133 methyl Me H cf3 2,2,2-trifluoroethyl 134 methyl Me H chf2 2,2,2-trifluoroethyl 135 methyl Me H iPr 2,2,2-trifluoroethyl 136 methyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 137 methyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 138 methyl Me methoxymethyl iPr 2,2,2-trifluoroethyl 139 methyl CN H cf3 2,2,2-trifluoroethyl 140 methyl CN H chf2 2,2,2-trifluoroethyl 141 methyl CN H iPr 2,2,2-trifluoroethyl 142 methyl CN methoxymethyl cf3 2,2,2-trifluoroethyl 143 methyl CN methoxymethyl chf2 2,2,2-trifluoroethyl 144 methyl CN methoxymethyl iPr 2,2,2-trifluoroethyl 145 H Cl H ..... cf3 2,2-difluoroethyl 146 H Cl H chf2 2,2-difluoroethyl 147 H Cl H iPr 2,2-difluoroethyl 148 H Cl methoxymethyl cf3 2,2-difluoroethyl 149 H Cl methoxymethyl chf2 2,2-difluoroethyl 150 H Cl methoxymethyl iPr 2,2-difluoroethyl Index R3 R7 R1 151 i H         ..................... Me ! H ~~——~~ cf3 2,2-difluoroethyl 152 H Me H chf2 2,2-difluoroethyl 153 H Me H iPr 2,2-difluoroethyl 154 H Me methoxymethyl cf3 2,2-difluoroethyl 155 H Me methoxymethyl chf2 2,2-difluoroethyl 156 H Me methoxymethyl iPr 2,2-difluoroethyl 157 H CN H cf3 2,2-difluoroethyl 158 H CN H chf2 2,2-difluoroethyl 159 H CN H iPr 2,2-difluoroethyl 160 H CN methoxymethyl cf3 2,2-difluoroethyl 161 H CN methoxymethyl chf2 2,2-difluoroethyl 162 H CN methoxymethyl iPr 2,2-difluoroethyl 163 methyl Cl H cf3 2,2-difluoroethyl 164 methyl Cl H chf2 2,2-difluoroethyl 165 methyl Cl H iPr 2,2-difluoroethyl 166 methyl Cl methoxymethyl cf3 2,2-difluoroethyl 167 methyl Cl methoxymethyl chf2 2,2-difluoroethyl 168 methyl Cl methoxymethyl iPr 2,2-difluoroethyl 169 methyl Me H cf3 2,2-difluoroethyl 170 methyl Me H chf2 2,2-difluoroethyl 171 methyl Me H iPr 2,2-difluoroethyl 172 methyl Me methoxymethyl cf3 2,2-difluoroethyl 173 methyl Me methoxymethyl chf2 2,2-difluoroethyl 174 methyl Me methoxymethyl iPr 2,2-difluoroethyl 175 methyl CN H cf3 2,2-difluoroethyl 176 methyl CN H chf2 2,2-difluoroethyl 177 methyl CN H iPr 2,2-difluoroethyl 178 methyl CN methoxymethyl cf3 2,2-difluoroethyl 179 methyl CN methoxymethyl chf2 2,2-difluoroethyl 180 methyl CN methoxymethyl iPr 2,2-difluoroethyl 181 H Cl H cf3 cyclopropyl 182 H Cl H chf2 cyclopropyl 183 H Cl H iPr cyclopropyl 184 H Cl methoxymethyl cf3 cyclopropyl 185 H Cl methoxymethyl chf2 cyclopropyl 186 H Cl methoxymethyl iPr cyclopropyl 187 H Me H cf3 cyclopropyl 188 H Me H chf2 cyclopropyl 189 H Me H iPr cyclopropyl 190 H Me methoxymethyl cf3 cyclopropyl 191 H Me methoxymethyl chf2 cyclopropyl 192 H Me methoxymethyl iPr cyclopropyl 193 H CN H cf3 cyclopropyl 194 H CN H chf2 cyclopropyl 195 H CN H iPr cyclopropyl 196 H CN methoxymethyl cf3 cyclopropyl Index R3 [111 / / / / / / / / / / R7 R1 197 j H CN methoxymethyl chf2 cyclopropyl 198 H CN methoxymethyl iPr cyclopropyl 199 methyl Cl H cf3 cyclopropyl 200 methyl ci H chf2 cyclopropyl 201 methyl Cl H......... iPr cyclopropyl 202 methyl Cl methoxymethyl cf3 cyclopropyl 203 methyl Cl methoxymethyl chf2 cyclopropyl 204 methyl Cl methoxymethyl iPr cyclopropyl 205 methyl Me H cf3 cyclopropyl 206 methyl Me H chf2 cyclopropyl 207 methyl Me H iPr cyclopropyl 208 methyl Me methoxymethyl cf3 cyclopropyl 209 methyl Me methoxymethyl chf2 cyclopropyl 210 methyl Me methoxymethyl iPr cyclopropyl 211 methyl CN H cf3 cyclopropyl 212 methyl CN H chf2 cyclopropyl 213 methyl CN H iPr cyclopropyl 214 methyl CN methoxymethyl cf3 cyclopropyl 215 methyl CN methoxymethyl chf2 cyclopropyl 216 methyl CN methoxymethyl iPr cyclopropyl 217 H Cl H cf3 1-cyanocyclopropy 218 H Cl H chf2 1-cyanocyclopropy 219 H Cl H iPr 1-cyanocyclopropy 220 H Cl methoxymethyl cf3 1-cyanocyclopropy 221 H Cl methoxymethyl chf2 1-cyanocyclopropy 222 H Cl methoxymethyl iPr 1-cyanocyclopropy 223 H Me H cf3 1-cyanocyclopropy 224 H Me H chf2 1-cyanocyclopropy 225 H Me H iPr 1-cyanocyclopropy 226 H Me methoxymethyl cf3 1-cyanocyclopropy 227 H Me methoxymethyl chf2 1-cyanocyclopropy 228 H Me methoxymethyl iPr 1-cyanocyclopropy 229 H CN H cf3 1-cyanocyclopropy 230 H CN H chf2 1-cyanocyclopropy 231 H CN H iPr 1-cyanocyclopropy 232 H CN methoxymethyl cf3 1-cyanocyclopropy 233 H CN methoxymethyl chf2 1-cyanocyclopropy 234 H CN methoxymethyl iPr 1-cyanocyclopropy 235 methyl Cl H cf3 1-cyanocyclopropy 236 methyl Cl H chf2 1-cyanocyclopropy 237 methyl Cl H ..... iPr 1-cyanocyclopropy 238 methyl Cl methoxymethyl cf3 1-cyanocyclopropy 239 methyl Cl methoxymethyl chf2 1-cyanocyclopropy 240 methyl Cl methoxymethyl iPr 1-cyanocyclopropy 241 methyl Me H cf3 1-cyanocyclopropy 242 methyl Me H chf2 1-cyanocyclopropy Index R3 R7 R1 243 methyl Me ! H — iPr 1-cyanocyclopropyl 244 methyl Me methoxymethyl cf3 1-cyanocyclopropyl 245 methyl Me methoxymethyl CHF2 1-cyanocyclopropyl 246 methyl Me methoxymethyl iPr 1-cyanocyclopropyl 247 methyl CN H......... cf3 1-cyanocyclopropyl 248 methyl CN H chf2 1-cyanocyclopropyl 249 methyl CN H iPr 1-cyanocyclopropyl 250 methyl CN methoxymethyl cf3 1-cyanocyclopropyl 251 methyl CN methoxymethyl chf2 1-cyanocyclopropyl 252 methyl CN methoxymethyl iPr 1-cyanocyclopropyl 253 H Cl H cf3 1-cyanocyclobutyl 254 H Cl H chf2 1-cyanocyclobutyl 255 H Cl H iPr 1-cyanocyclobutyl 256 H Cl methoxymethyl cf3 1-cyanocyclobutyl 257 H Cl methoxymethyl chf2 1-cyanocyclobutyl 258 H Cl methoxymethyl iPr 1-cyanocyclobutyl 259 H Me H cf3 1-cyanocyclobutyl 260 H Me H chf2 1-cyanocyclobutyl 261 H Me H iPr 1-cyanocyclobutyl 262 H Me methoxymethyl cf3 1-cyanocyclobutyl 263 H Me methoxymethyl chf2 1-cyanocyclobutyl 264 H Me methoxymethyl iPr 1-cyanocyclobutyl 265 H CN H cf3 1-cyanocyclobutyl 266 H CN H chf2 1-cyanocyclobutyl 267 H CN H iPr 1-cyanocyclobutyl 268 H CN methoxymethyl cf3 1-cyanocyclobutyl 269 H CN methoxymethyl chf2 1-cyanocyclobutyl 270 H CN methoxymethyl iPr 1-cyanocyclobutyl 271 methyl Cl H cf3 1-cyanocyclobutyl 272 methyl Cl H chf2 1-cyanocyclobutyl 273 methyl Cl H iPr 1-cyanocyclobutyl 274 methyl Cl methoxymethyl cf3 1-cyanocyclobutyl 275 methyl Cl methoxymethyl chf2 1-cyanocyclobutyl 276 methyl Cl methoxymethyl iPr 1-cyanocyclobutyl 277 methyl Me H cf3 1-cyanocyclobutyl 278 methyl Me H chf2 1-cyanocyclobutyl 279 methyl Me H iPr 1-cyanocyclobutyl 280 methyl Me methoxymethyl cf3 1-cyanocyclobutyl 281 methyl Me methoxymethyl chf2 1-cyanocyclobutyl 282 methyl Me methoxymethyl iPr 1-cyanocyclobutyl 283 methyl CN H ..... cf3 1-cyanocyclobutyl 284 methyl CN H chf2 1-cyanocyclobutyl 285 methyl CN H iPr 1-cyanocyclobutyl 286 methyl CN methoxymethyl cf3 1-cyanocyclobutyl 287 methyl CN methoxymethyl chf2 1-cyanocyclobutyl 288 methyl CN methoxymethyl iPr 1-cyanocyclobutyl Index R3 R7 R1 289 H Cl H cf3 3,3-difluorocyclobutyl 290 H Cl H chf2 3,3-difluorocyclobutyl 291 H Cl H iPr 3,3-difluorocyclobutyl 292 H Cl methoxymethyl cf3 3,3-difluorocyclobutyl 293 " H.............. Cl methoxymethyl chf2 3,3-difluorocyclobutyl 294 H Cl methoxymethyl iPr 3,3-difluorocyclobutyl 295 H Me H cf3 3,3-difluorocyclobutyl 296 H Me H chf2 3,3-difluorocyclobutyl 297 H Me H iPr 3,3-difluorocyclobutyl 298 H Me methoxymethyl cf3 3,3-difluorocyclobutyl 299 H Me methoxymethyl chf2 3,3-difluorocyclobutyl 300 H Me methoxymethyl iPr 3,3-difluorocyclobutyl 301 H CN H cf3 3,3-difluorocyclobutyl 302 H CN H chf2 3,3-difluorocyclobutyl 303 H CN H iPr 3,3-difluorocyclobutyl 304 H CN methoxymethyl cf3 3,3-difluorocyclobutyl 305 H CN methoxymethyl chf2 3,3-difluorocyclobutyl 306 H CN methoxymethyl iPr 3,3-difluorocyclobutyl 307 methyl Cl H cf3 3,3-difluorocyclobutyl 308 methyl Cl H chf2 3,3-difluorocyclobutyl 309 methyl Cl H iPr 3,3-difluorocyclobutyl 310 methyl Cl methoxymethyl cf3 3,3-difluorocyclobutyl 311 methyl Cl methoxymethyl chf2 3,3-difluorocyclobutyl 312 methyl Cl methoxymethyl iPr 3,3-difluorocyclobutyl 313 methyl Me H cf3 3,3-difluorocyclobutyl 314 methyl Me H chf2 3,3-difluorocyclobutyl 315 methyl Me H iPr 3,3-difluorocyclobutyl 316 methyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 317 methyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 318 methyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 319 methyl CN H cf3 3,3-difluorocyclobutyl 320 methyl CN H chf2 3,3-difluorocyclobutyl 321 methyl CN H iPr 3,3-difluorocyclobutyl 322 methyl CN methoxymethyl cf3 3,3-difluorocyclobutyl 323 methyl CN methoxymethyl chf2 3,3-difluorocyclobutyl 324 methyl CN methoxymethyl iPr 3,3-difluorocyclobutyl 325 H Cl H cf3 1,1-dioxothietan-3-yl 326 H Cl H chf2 1,1-dioxothietan-3-yl 327 H Cl H iPr 1,1-dioxothietan-3-yl 328 H Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 329 H Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 330 H Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 331 H Me H cf3 1,1-dioxothietan-3-yl 332 H Me H chf2 1,1-dioxothietan-3-yl 333 H Me H iPr 1,1-dioxothietan-3-yl 334 H Me methoxymethyl cf3 1,1-dioxothietan-3-yl Index R3 R7 R1 335 i H         ..................... Me methoxymethyl chf2 1,1-dioxothietan-3-yl 336 H Me methoxymethyl iPr 1,1-dioxothietan-3-yl 337 H CN H cf3 1,1-dioxothietan-3-yl 338 H CN H chf2 1,1-dioxothietan-3-yl 339 H CN H......... iPr 1,1-dioxothietan-3-yl 340 H CN methoxymethyl cf3 1,1-dioxothietan-3-yl 341 H CN methoxymethyl chf2 1,1-dioxothietan-3-yl 342 H CN methoxymethyl iPr 1,1-dioxothietan-3-yl 343 methyl Cl H cf3 1,1-dioxothietan-3-yl 344 methyl Cl H chf2 1,1-dioxothietan-3-yl 345 methyl Cl H iPr 1,1-dioxothietan-3-yl 346 methyl Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 347 methyl Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 348 methyl Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 349 methyl Me H cf3 1,1-dioxothietan-3-yl 350 methyl Me H chf2 1,1-dioxothietan-3-yl 351 methyl Me H iPr 1,1-dioxothietan-3-yl 352 methyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 353 methyl Me methoxymethyl chf2 1,1-dioxothietan-3-yl 354 methyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl 355 methyl CN H cf3 1,1-dioxothietan-3-yl 356 methyl CN H chf2 1,1-dioxothietan-3-yl 357 methyl CN H iPr 1,1-dioxothietan-3-yl 358 methyl CN methoxymethyl cf3 1,1-dioxothietan-3-yl 359 methyl CN methoxymethyl chf2 1,1-dioxothietan-3-yl 360 methyl CN methoxymethyl iPr 1,1-dioxothietan-3-yl 361 H Cl H cf3 cyclopropylmethyl 362 H Cl H chf2 cyclopropylmethyl 363 H Cl H iPr cyclopropylmethyl 364 H Cl methoxymethyl cf3 cyclopropylmethyl 365 H Cl methoxymethyl chf2 cyclopropylmethyl 366 H Cl methoxymethyl iPr cyclopropylmethyl 367 H Me H cf3 cyclopropylmethyl 368 H Me H chf2 cyclopropylmethyl 369 H Me H iPr cyclopropylmethyl 370 H Me methoxymethyl cf3 cyclopropylmethyl 371 H Me methoxymethyl chf2 cyclopropylmethyl 372 H Me methoxymethyl iPr cyclopropylmethyl 373 H CN H cf3 cyclopropylmethyl 374 H CN H chf2 cyclopropylmethyl 375 H CN H ..... iPr cyclopropylmethyl 376 H CN methoxymethyl cf3 cyclopropylmethyl 377 H CN methoxymethyl chf2 cyclopropylmethyl 378 H CN methoxymethyl iPr cyclopropylmethyl 379 methyl Cl H cf3 cyclopropylmethyl 380 methyl Cl H chf2 cyclopropylmethyl Index R3 R7 R1 381 methyl ! H ———~~ iPr cyclopropylmethyl 382 methyl Cl methoxymethyl cf3 cyclopropylmethyl 383 methyl Cl methoxymethyl CHF2 cyclopropylmethyl 384 methyl Cl methoxymethyl iPr cyclopropylmethyl 385 methyl Me H......... cf3 cyclopropylmethyl 386 methyl Me H chf2 cyclopropylmethyl 387 methyl Me H iPr cyclopropylmethyl 388 methyl Me methoxymethyl cf3 cyclopropylmethyl 389 methyl Me methoxymethyl chf2 cyclopropylmethyl 390 methyl Me methoxymethyl iPr cyclopropylmethyl 391 methyl CN H cf3 cyclopropylmethyl 392 methyl CN H chf2 cyclopropylmethyl 393 methyl CN H iPr cyclopropylmethyl 394 methyl CN methoxymethyl cf3 cyclopropylmethyl 395 methyl CN methoxymethyl chf2 cyclopropylmethyl 396 methyl CN methoxymethyl iPr cyclopropylmethyl Table 3: Makes available 133 compounds of the formula (l-3a), where the substituents R1, R2’ R3, R6 and R7 are designated in each row below: Index R3 R7 R1 1 H Me H cf3 ethyl 2 H Me H chf2 ethyl 3 H      ..... Me H iPr ethyl 4 H Me methoxymethyl cf3 ethyl 5 H Me methoxymethyl chf2 ethyl 6 H Me methoxymethyl iPr ethyl 7 methyl Me H cf3 ethyl 8 methyl Me H chf2 ethyl 9 methyl Me H iPr ethyl 10 methyl Me methoxymethyl cf3 ethyl 11 methyl Me methoxymethyl chf2 ethyl 12 methyl Me methoxymethyl iPr ethyl 13 H Me H cf3 isopropyl 14 H Me H chf2 isopropyl 15 H Me H iPr isopropyl 16 H Me methoxymethyl cf3 isopropyl 17 H Me methoxymethyl chf2 isopropyl 18 H Me methoxymethyl iPr isopropyl 19 methyl Me H cf3 isopropyl 20 methyl Me H chf2 isopropyl 21 methyl Me H iPr isopropyl 22 methyl Me methoxymethyl cf3 isopropyl 23 methyl Me methoxymethyl chf2 isopropyl 24 methyl Me methoxymethyl iPr isopropyl Index R3 R7 Ollillllllllil 25 i H         ..................... Me i H   ———— cf3 propargyl 26 H Me H chf2 propargyl 27 H Me H iPr propargyl 28 H Me methoxymethyl cf3 propargyl 29 H Me methoxymethyl chf2 propargyl 30 H Me methoxymethyl iPr propargyl 31 methyl Me H cf3 propargyl 32 methyl Me H chf2 propargyl 33 methyl Me H iPr propargyl 34 methyl Me methoxymethyl cf3 propargyl 35 methyl Me methoxymethyl chf2 propargyl 36 methyl Me methoxymethyl iPr propargyl 37 H Me H cf3 2,2,2-trifluoroethyl 38 H Me H chf2 2,2,2-trifluoroethyl 39 H Me H iPr 2,2,2-trifluoroethyl 40 H Me methoxymethyl cf3 2,2,2-trifluoroethyl 41 H Me methoxymethyl chf2 2,2,2-trifluoroethyl 42 H Me methoxymethyl iPr 2,2,2-trifluoroethyl 43 methyl Me H cf3 2,2,2-trifluoroethyl 44 methyl Me H chf2 2,2,2-trifluoroethyl 45 methyl Me H iPr 2,2,2-trifluoroethyl 46 methyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 47 methyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 48 methyl Me methoxymethyl iPr 2,2,2-trifluoroethyl 49 H Me H cf3 2,2-difluoroethyl 50 H Me H chf2 2,2-difluoroethyl 51 H Me H iPr 2,2-difluoroethyl 52 H Me methoxymethyl cf3 2,2-difluoroethyl 53 H Me methoxymethyl chf2 2,2-difluoroethyl 54 H Me methoxymethyl iPr 2,2-difluoroethyl 55 methyl Me H cf3 2,2-difluoroethyl 56 methyl Me H chf2 2,2-difluoroethyl 57 methyl Me H iPr 2,2-difluoroethyl 58 methyl Me methoxymethyl cf3 2,2-difluoroethyl 59 methyl Me methoxymethyl chf2 2,2-difluoroethyl 60 methyl Me methoxymethyl iPr 2,2-difluoroethyl 61 H Me H cf3 cyclopropyl 62 H Me H CHF2 cyclopropyl 63 H Me H iPr cyclopropyl 64 H Me methoxymethyl cf3 cyclopropyl 65 H Me methoxymethyl chf2 cyclopropyl 66 H Me methoxymethyl iPr cyclopropyl 67 methyl Me H cf3 cyclopropyl 68 methyl Me H chf2 cyclopropyl 69 methyl Me H iPr cyclopropyl 70 methyl Me methoxymethyl cf3 cyclopropyl Index R3 R7 71 methyl Me methoxymethyl chf2 cyclopropyl 72 methyl Me methoxymethyl iPr cyclopropyl 73 H Me H cf3 1-cyanocyclopropyl 74 H Me H chf2 1-cyanocyclopropyl 75 H Me H iPr 1-cyanocyclopropyl 76 H Me methoxymethyl cf3 1-cyanocyclopropyl 77 H Me methoxymethyl chf2 1-cyanocyclopropyl 78 H Me methoxymethyl iPr 1-cyanocyclopropyl 79 methyl Me H cf3 1-cyanocyclopropyl 80 methyl Me H chf2 1-cyanocyclopropyl 81 methyl Me H iPr 1-cyanocyclopropyl 82 methyl Me methoxymethyl cf3 1-cyanocyclopropyl 83 methyl Me methoxymethyl chf2 1-cyanocyclopropyl 84 methyl Me methoxymethyl iPr 1-cyanocyclopropyl 85 H Me H cf3 1-cyanocyclobutyl 86 H Me H chf2 1-cyanocyclobutyl 87 H Me H iPr 1-cyanocyclobutyl 88 H Me methoxymethyl cf3 1-cyanocyclobutyl 89 H Me methoxymethyl chf2 1-cyanocyclobutyl 90 H Me methoxymethyl iPr 1-cyanocyclobutyl 91 methyl Me H cf3 1-cyanocyclobutyl 92 methyl Me H chf2 1-cyanocyclobutyl 93 methyl Me H iPr 1-cyanocyclobutyl 94 methyl Me methoxymethyl cf3 1-cyanocyclobutyl 95 methyl Me methoxymethyl chf2 1-cyanocyclobutyl 96 methyl Me methoxymethyl iPr 1-cyanocyclobutyl 97 H Me H cf3 3,3-difluorocyclobutyl 98 H Me H chf2 3,3-difluorocyclobutyl 99 H Me H iPr 3,3-difluorocyclobutyl 100 H Me methoxymethyl cf3 3,3-difluorocyclobutyl 101 H Me methoxymethyl chf2 3,3-difluorocyclobutyl 102 H Me methoxymethyl iPr 3,3-difluorocyclobutyl 103 methyl Me H cf3 3,3-difluorocyclobutyl 104 methyl Me H chf2 3,3-difluorocyclobutyl 105 methyl Me H iPr 3,3-difluorocyclobutyl 106 methyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 107 methyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 108 methyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 109 H Me H cf3 1,1-dioxothietan-3-yl 110 H Me H chf2 1,1-dioxothietan-3-yl 111 H Me H iPr 1,1-dioxothietan-3-yl 112 H Me methoxymethyl cf3 1,1-dioxothietan-3-yl 113 H Me methoxymethyl chf2 1,1-dioxothietan-3-yl 114 H Me methoxymethyl iPr 1,1-dioxothietan-3-yl 115 methyl Me H cf3 1,1-dioxothietan-3-yl 116 methyl Me H chf2 1,1-dioxothietan-3-yl Index R3 R7 litillllllllllllllll 117 methyl Me i H   —— iPr 1,1-dioxothietan-3-yl 118 methyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 119 methyl Me methoxymethyl chf2 1,1-dioxothietan-3-yl 120 methyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl 121 H Me H cf3 cyclopropylmethyl 122 H Me H chf2 cyclopropylmethyl 123 H Me H iPr cyclopropylmethyl 124 H Me methoxymethyl cf3 cyclopropylmethyl 125 H Me methoxymethyl chf2 cyclopropylmethyl 126 H Me methoxymethyl : iPr cyclopropylmethyl 127 methyl Me H cf3 cyclopropylmethyl 128 methyl Me H chf2 cyclopropylmethyl 129 methyl Me H iPr cyclopropylmethyl 130 methyl Me methoxymethyl cf3 cyclopropylmethyl 131 methyl Me methoxymethyl chf2 cyclopropylmethyl 132 methyl Me methoxymethyl iPr cyclopropylmethyl 133 H Cl H cf3 2-bicyclo[1.1,1]pentanyl Table 4: Makes available 282 compounds of the formula (l-4a), where the substituents R1, R2’ R3, R6 and R7 are designated in each row below: Index |R2          . R3 IBISIIIIIO R7 R1 1 H Cl H cf3 ethyl 2 H Cl H chf2 ethyl 3 H Cl H iPr ethyl 4 H Cl methoxymethyl cf3 ethyl 5 H Cl methoxymethyl chf2 ethyl 6 H Cl methoxymethyl iPr ethyl 7 H Me H cf3 ethyl 8 H Me H chf2 ethyl 9 H Me H iPr ethyl 10 H Me methoxymethyl cf3 ethyl 11 H Me methoxymethyl chf2 ethyl 12 H Me methoxymethyl iPr ethyl 13 methyl Cl H cf3 ethyl 14 methyl Cl H chf2 ethyl 15 methyl Cl H iPr ethyl 16 methyl Cl methoxymethyl cf3 ethyl 17 methyl Cl methoxymethyl chf2 ethyl 18 methyl Cl methoxymethyl iPr ethyl 19 methyl Me H cf3 ethyl 20 methyl Me H chf2 ethyl 21 methyl Me H iPr ethyl 22 methyl Me methoxymethyl cf3 ethyl 23 methyl Me methoxymethyl chf2 ethyl Index R3 R7 R1 24 methyl Me methoxymethyl iPr ethyl 25 H Cl H cf3 isopropyl 26 H Cl H chf2 isopropyl 27 H Cl H iPr isopropyl 28 H Cl methoxymethyl cf3 isopropyl 29 H Cl methoxymethyl chf2 isopropyl 30 H Cl methoxymethyl IPr isopropyl 31 H Me H cf3 isopropyl 32 H Me H chf2 isopropyl 33 H Me H : iPr isopropyl 34 H Me methoxymethyl cf3 isopropyl 35 H Me methoxymethyl chf2 isopropyl 36 H Me methoxymethyl iPr isopropyl 37 methyl Cl H cf3 isopropyl 38 methyl Cl H chf2 isopropyl 39 methyl Cl H iPr isopropyl 40 methyl Cl methoxymethyl cf3 isopropyl 41 methyl Cl methoxymethyl chf2 isopropyl 42 methyl Cl methoxymethyl iPr isopropyl 43 methyl Me H cf3 isopropyl 44 methyl Me H chf2 isopropyl 45 methyl Me H iPr isopropyl 46 methyl Me methoxymethyl cf3 isopropyl 47 methyl Me methoxymethyl chf2 isopropyl 48 methyl Me methoxymethyl iPr isopropyl 49 H Cl H cf3 propargyl 50 H Cl H chf2 propargyl 51 H Cl H iPr propargyl 52 H Cl methoxymethyl cf3 propargyl 53 H Cl methoxymethyl chf2 propargyl 54 H Cl methoxymethyl iPr propargyl 55 H Me H cf3 propargyl 56 H Me H chf2 propargyl 57 H Me H iPr propargyl 58 H Me methoxymethyl cf3 propargyl 59 H Me methoxymethyl chf2 propargyl 60 H Me methoxymethyl iPr propargyl 61 methyl Cl H CF3 propargyl 62 methyl Cl H chf2 propargyl 63 methyl Cl H iPr propargyl 64 methyl Cl methoxymethyl cf3 propargyl 65 methyl Cl methoxymethyl chf2 propargyl 66 methyl Cl methoxymethyl iPr propargyl 67 methyl Me H cf3 propargyl 68 methyl Me H chf2 propargyl 69 methyl Me H iPr propargyl Index R3 R7 Ollillllllllil 70 methyl Me methoxymethyl cf3 propargyl 71 methyl Me methoxymethyl chf2 propargyl 72 methyl Me methoxymethyl iPr propargyl 73 H Cl H cf3 2,2,2-trifluoroethyl 74 H Cl H chf2 2,2,2-trifluoroethyl 75 H Cl H iPr 2,2,2-trifluoroethyl 76 H Cl methoxymethyl cf3 2,2,2-trifluoroethyl 77 H Cl methoxymethyl chf2 2,2,2-trifluoroethyl 78 H Cl methoxymethyl iPr 2,2,2-trifluoroethyl 79 H Me H cf3 2,2,2-trifluoroethyl 80 H Me H chf2 2,2,2-trifluoroethyl 81 H Me H iPr 2,2,2-trifluoroethyl 82 H Me methoxymethyl cf3 2,2,2-trifluoroethyl 83 H Me methoxymethyl chf2 2,2,2-trifluoroethyl 84 H Me methoxymethyl iPr 2,2,2-trifluoroethyl 85 methyl Cl H cf3 2,2,2-trifluoroethyl 86 methyl Cl H chf2 2,2,2-trifluoroethyl 87 methyl Cl H iPr 2,2,2-trifluoroethyl 88 methyl Cl methoxymethyl cf3 2,2,2-trifluoroethyl 89 methyl Cl methoxymethyl chf2 2,2,2-trifluoroethyl 90 methyl Cl methoxymethyl iPr 2,2,2-trifluoroethyl 91 methyl Me H cf3 2,2,2-trifluoroethyl 92 methyl Me H chf2 2,2,2-trifluoroethyl 93 methyl Me H iPr 2,2,2-trifluoroethyl 94 methyl Me methoxymethyl cf3 2,2,2-trifluoroethyl 95 methyl Me methoxymethyl chf2 2,2,2-trifluoroethyl 96 methyl Me methoxymethyl iPr 2,2,2-trifluoroethyl 97 H Cl H cf3 2,2-difluoroethyl 98 H Cl H chf2 2,2-difluoroethyl 99 H Cl H iPr 2,2-difluoroethyl 100 H Cl methoxymethyl cf3 2,2-difluoroethyl 101 H Cl methoxymethyl chf2 2,2-difluoroethyl 102 H Cl methoxymethyl iPr 2,2-difluoroethyl 103 H Me H cf3 2,2-difluoroethyl 104 H Me H chf2 2,2-difluoroethyl 105 H Me H iPr 2,2-difluoroethyl 106 H Me methoxymethyl cf3 2,2-difluoroethyl 107 H Me methoxymethyl CHF2 2,2-difluoroethyl 108 H Me methoxymethyl iPr 2,2-difluoroethyl 109 methyl Cl H cf3 2,2-difluoroethyl 110 methyl Cl H chf2 2,2-difluoroethyl 111 methyl Cl H iPr 2,2-difluoroethyl 112 methyl Cl methoxymethyl cf3 2,2-difluoroethyl 113 methyl Cl methoxymethyl chf2 2,2-difluoroethyl 114 methyl Cl methoxymethyl iPr 2,2-difluoroethyl 115 methyl Me H cf3 2,2-difluoroethyl Index R3 R7 116 methyl Me i H   —— chf2 2,2-difluoroethyl 117 methyl Me H iPr 2,2-difluoroethyl 118 methyl Me methoxymethyl cf3 2,2-difluoroethyl 119 methyl Me methoxymethyl chf2 2,2-difluoroethyl 120 methyl Me methoxymethyl iPr 2,2-difluoroethyl 121 H Cl H cf3 cyclopropyl 122 H Cl H chf2 cyclopropyl 123 H Cl H iPr cyclopropyl 124 H Cl methoxymethyl cf3 cyclopropyl 125 H Cl methoxymethyl chf2 cyclopropyl 126 H Cl methoxymethyl iPr cyclopropyl 127 H Me H cf3 cyclopropyl 128 H Me H chf2 cyclopropyl 129 H Me H iPr cyclopropyl 130 H Me methoxymethyl cf3 cyclopropyl 131 H Me methoxymethyl chf2 cyclopropyl 132 H Me methoxymethyl iPr cyclopropyl 133 methyl Cl H cf3 cyclopropyl 134 methyl Cl H chf2 cyclopropyl 135 methyl Cl H iPr cyclopropyl 136 methyl Cl methoxymethyl cf3 cyclopropyl 137 methyl Cl methoxymethyl chf2 cyclopropyl 138 methyl Cl methoxymethyl iPr cyclopropyl 139 methyl Me H cf3 cyclopropyl 140 methyl Me H chf2 cyclopropyl 141 methyl Me H iPr cyclopropyl 142 methyl Me methoxymethyl cf3 cyclopropyl 143 methyl Me methoxymethyl chf2 cyclopropyl 144 methyl Me methoxymethyl iPr cyclopropyl 145 H Cl H cf3 1-cyanocyclopropyl 146 H Cl H chf2 1-cyanocyclopropyl 147 H Cl H iPr 1-cyanocyclopropyl 148 H Cl methoxymethyl cf3 1-cyanocyclopropyl 149 H Cl methoxymethyl chf2 1-cyanocyclopropyl 150 H Cl methoxymethyl iPr 1-cyanocyclopropyl 151 H Me H cf3 1-cyanocyclopropyl 152 H Me H chf2 1-cyanocyclopropyl 153 H Me H iPr 1-cyanocyclopropyl 154 H Me methoxymethyl cf3 1-cyanocyclopropyl 155 H Me methoxymethyl chf2 1-cyanocyclopropyl 156 H Me methoxymethyl iPr 1-cyanocyclopropyl 157 methyl Cl H cf3 1-cyanocyclopropyl 158 methyl Cl H chf2 1-cyanocyclopropyl 159 methyl Cl H iPr 1-cyanocyclopropyl 160 methyl Cl methoxymethyl cf3 1-cyanocyclopropyl 161 methyl Cl methoxymethyl chf2 1-cyanocyclopropyl Index R3 R7 162 methyl methoxymethyl iPr 1-cyanocyclopropyl 163 methyl Me H cf3 1-cyanocyclopropyl 164 methyl Me H chf2 1-cyanocyclopropyl 165 methyl Me H iPr 1-cyanocyclopropyl 166 methyl Me methoxymethyl cf3 1-cyanocyclopropyl 167 methyl Me methoxymethyl chf2 1-cyanocyclopropyl 168 methyl Me methoxymethyl iPr 1-cyanocyclopropyl 169 H Cl H cf3 1-cyanocyclobutyl 170 H Cl H chf2 1-cyanocyclobutyl 171 H Cl H : iPr 1-cyanocyclobutyl 172 H Cl methoxymethyl cf3 1-cyanocyclobutyl 173 H Cl methoxymethyl chf2 1-cyanocyclobutyl 174 H Cl methoxymethyl iPr 1-cyanocyclobutyl 175 H Me H cf3 1-cyanocyclobutyl 176 H Me H chf2 1-cyanocyclobutyl 177 H Me H iPr 1-cyanocyclobutyl 178 H Me methoxymethyl cf3 1-cyanocyclobutyl 179 H Me methoxymethyl chf2 1-cyanocyclobutyl 180 H Me methoxymethyl iPr 1-cyanocyclobutyl 181 methyl Cl H cf3 1-cyanocyclobutyl 182 methyl Cl H chf2 1-cyanocyclobutyl 183 methyl Cl H iPr 1-cyanocyclobutyl 184 methyl Cl methoxymethyl cf3 1-cyanocyclobutyl 185 methyl Cl methoxymethyl chf2 1-cyanocyclobutyl 186 methyl Cl methoxymethyl iPr 1-cyanocyclobutyl 187 methyl Me H cf3 1-cyanocyclobutyl 188 methyl Me H chf2 1-cyanocyclobutyl 189 methyl Me H iPr 1-cyanocyclobutyl 190 methyl Me methoxymethyl cf3 1-cyanocyclobutyl 191 methyl Me methoxymethyl chf2 1-cyanocyclobutyl 192 methyl Me methoxymethyl iPr 1-cyanocyclobutyl 193 H Cl H cf3 3,3-difluorocyclobutyl 194 H Cl H chf2 3,3-difluorocyclobutyl 195 H Cl H iPr 3,3-difluorocyclobutyl 196 H Cl methoxymethyl cf3 3,3-difluorocyclobutyl 197 H Cl methoxymethyl chf2 3,3-difluorocyclobutyl 198 H Cl methoxymethyl iPr 3,3-difluorocyclobutyl 199 H Me H CF3 3,3-difluorocyclobutyl 200 H Me H chf2 3,3-difluorocyclobutyl 201 H Me H iPr 3,3-difluorocyclobutyl 202 H Me methoxymethyl cf3 3,3-difluorocyclobutyl 203 H Me methoxymethyl chf2 3,3-difluorocyclobutyl 204 H Me methoxymethyl iPr 3,3-difluorocyclobutyl 205 methyl Cl H cf3 3,3-difluorocyclobutyl 206 methyl Cl H chf2 3,3-difluorocyclobutyl 207 methyl Cl H iPr 3,3-difluorocyclobutyl Index R3 R7 208 methyl methoxymethyl cf3 3,3-difluorocyclobutyl 209 methyl Cl methoxymethyl chf2 3,3-difluorocyclobutyl 210 methyl Cl methoxymethyl iPr 3,3-difluorocyclobutyl 211 methyl Me H cf3 3,3-difluorocyclobutyl 212 methyl Me H chf2 3,3-difluorocyclobutyl 213 methyl Me H iPr 3,3-difluorocyclobutyl 214 methyl Me methoxymethyl cf3 3,3-difluorocyclobutyl 215 methyl Me methoxymethyl chf2 3,3-difluorocyclobutyl 216 methyl Me methoxymethyl iPr 3,3-difluorocyclobutyl 217 H Cl H cf3 1,1-dioxothietan-3-yl 218 H Cl H chf2 1,1-dioxothietan-3-yl 219 H Cl H iPr 1,1-dioxothietan-3-yl 220 H Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 221 H Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 222 H Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 223 H Me H cf3 1,1-dioxothietan-3-yl 224 H Me H chf2 1,1-dioxothietan-3-yl 225 H Me H iPr 1,1-dioxothietan-3-yl 226 H Me methoxymethyl cf3 1,1-dioxothietan-3-yl 227 H Me methoxymethyl chf2 1,1-dioxothietan-3-yl 228 H Me methoxymethyl iPr 1,1-dioxothietan-3-yl 229 methyl Cl H cf3 1,1-dioxothietan-3-yl 230 methyl Cl H chf2 1,1-dioxothietan-3-yl 231 methyl Cl H iPr 1,1-dioxothietan-3-yl 232 methyl Cl methoxymethyl cf3 1,1-dioxothietan-3-yl 233 methyl Cl methoxymethyl chf2 1,1-dioxothietan-3-yl 234 methyl Cl methoxymethyl iPr 1,1-dioxothietan-3-yl 235 methyl Me H cf3 1,1-dioxothietan-3-yl 236 methyl Me H chf2 1,1-dioxothietan-3-yl 237 methyl Me H iPr 1,1-dioxothietan-3-yl 238 methyl Me methoxymethyl cf3 1,1-dioxothietan-3-yl 239 methyl Me methoxymethyl chf2 1,1-dioxothietan-3-yl 240 methyl Me methoxymethyl iPr 1,1-dioxothietan-3-yl 241 H Cl H cf3 cyclopropylmethyl 242 H Cl H chf2 cyclopropylmethyl 243 H Cl H iPr cyclopropylmethyl 244 H Cl methoxymethyl cf3 cyclopropylmethyl 245 H Cl methoxymethyl CHF2 cyclopropylmethyl 246 H Cl methoxymethyl iPr cyclopropylmethyl 247 H Me H cf3 cyclopropylmethyl 248 H Me H chf2 cyclopropylmethyl 249 H Me H iPr cyclopropylmethyl 250 H Me methoxymethyl cf3 cyclopropylmethyl 251 H Me methoxymethyl chf2 cyclopropylmethyl 252 H Me methoxymethyl iPr cyclopropylmethyl 253 methyl Cl H cf3 cyclopropylmethyl Index R3 R7 254 methyl i H   —— chf2 cyclopropylmethyl 255 methyl Cl H iPr cyclopropylmethyl 256 methyl Cl methoxymethyl cf3 cyclopropylmethyl 257 methyl Cl methoxymethyl chf2 cyclopropylmethyl 258 methyl Cl methoxymethyl iPr cyclopropylmethyl 259 methyl Me H cf3 cyclopropylmethyl 260 methyl Me H chf2 cyclopropylmethyl 261 methyl Me H iPr cyclopropylmethyl 262 methyl Me methoxymethyl cf3 cyclopropylmethyl 263 methyl Me methoxymethyl chf2 cyclopropylmethyl 264 methyl Me methoxymethyl iPr cyclopropylmethyl 265 H Me H cf3 2-bicyclo[1.1,1]pentanyl 266 H Me H cf3 4-ethylthiazole-5-yl 267 H Me H cf3 (1,3-dihydroisobenzofuran-5-yl) methyl 268 H Me H cf3 3-oxo-2-(2,2,2- trifluoroethyl)isoxazolidine-4-yl 269 H Me H cf3 2-(2-fluorophenoxy)ethyl 270 H Me H cf3 6-methoxy-2-methyl-hex-3-yn-2-yl 271 H Me H cf3 1-cyclopropyl ethyl 272 H Me H cf3 1-(2-ethylthiazol-4-yl)ethyl 273 H Me H cf3 2-fluoro 3-cyano phenyl 274 H Me H cf3 benzyl 275 H Me H cf3 1-(3-pyridyl)ethyl 276 H Me methoxymethyl cf3 3-oxo-2-ethyl isoxazolidine-4-yl 277 H Br methoxymethyl cf3 cyclopropyl 278 H Br methoxymethyl cf3 1-cyano cyclopropyl 279 H Br H cf3 cyclopropyl 280 H Br H cf3 1-cyano cyclopropyl 281 H Br H cf3 3-oxo-2-ethyl isoxazolidine-4-yl 282 H Br H          ..... cf3 2,2,2-trifluoroethyl Table 5: Makes available 54 compounds of the formula (l-5a), where the substituents R1, R3, X, Y and Z are designated in each row below: Index Z X Y R3 1 CH CH N 2,2,2-trifluoroethyl Cl 2 CH CH N cyclopropyl Cl 3 CH CH N 1-cyanocyclopropyl ..... Cl 4 CH N CH 2,2,2-trifluoroethyl Cl 5 CH N CH cyclopropyl Cl 6 CH N CH 1-cyanocyclopropyl Cl 7 CH N N 2,2,2-trifluoroethyl Cl 8 CH N N cyclopropyl Cl 9 CH N N 1-cyanocyclopropyl Cl 10 N CH CH 2,2,2-trifluoroethyl Cl 11 N CH CH cyclopropyl Cl Index Z X Y iOiiiiw R3 12 N CH CH 1-cyanocyclopropyl cT 13 N CH N 2,2,2-trifluoroethyl Cl 14 N CH N cyclopropyl Cl 15 N CH N 1-cyanocyclopropyl Cl 16 N N CH 2,2,2-trifluoroethyl Cl 17 N N CH cyclopropyl Cl 18 N N CH 1-cyanocyclopropyl Cl 19 CH CH N 2,2,2-trifluoroethyl Br 20 CH CH N cyclopropyl Br 21 CH CH N 1-cyanocyclopropyl Br 22 CH N CH 2,2,2-trifluoroethyl Br 23 CH N CH cyclopropyl Br 24 CH N CH 1-cyanocyclopropyl Br 25 CH N N 2,2,2-trifluoroethyl Br 26 CH N N cyclopropyl Br 27 CH N N 1-cyanocyclopropyl Br 28 N CH CH 2,2,2-trifluoroethyl Br 29 N CH CH cyclopropyl Br 30 N CH CH 1-cyanocyclopropyl Br 31 N CH N 2,2,2-trifluoroethyl Br 32 N CH N cyclopropyl Br 33 N CH N 1-cyanocyclopropyl Br 34 N N CH 2,2,2-trifluoroethyl Br 35 N N CH cyclopropyl Br 36 N N CH 1-cyanocyclopropyl Br 37 CH CH N 2,2,2-trifluoroethyl Me 38 CH CH N cyclopropyl Me 39 CH CH N 1-cyanocyclopropyl Me 40 CH N CH 2,2,2-trifluoroethyl Me 41 CH N CH cyclopropyl Me 42 CH N CH 1-cyanocyclopropyl Me 43 CH N N 2,2,2-trifluoroethyl Me 44 CH N N cyclopropyl Me 45 CH N N 1-cyanocyclopropyl Me 46 N CH CH 2,2,2-trifluoroethyl Me 47 N CH CH cyclopropyl Me 48 N CH CH 1-cyanocyclopropyl Me 49 N CH N 2,2,2-trifluoroethyl Me 50 N CH N cyclopropyl Me 51 N CH N 1-cyanocyclopropyl Me 52 N N CH 2,2,2-trifluoroethyl Me 53 N N CH cyclopropyl Me 54 N N CH 1-cyanocyclopropyl Me Also made available are certain intermediate compounds, some of which are novel. Accordingly, made available herein are: A. compounds of formulae (11-1), (H-2), (II-3) and (II-4), wherein R3, R6 and R7 are as defined in Tables 1 to 5 respectively. B. compounds of formulae (IV-1), (IV-2), (IV-3), and (IV-4), wherein R3, R6 and R7 are as defined in Tables 1 to 5 respectively, and wherein G is halogen or Gi to G4. 10 C. compounds of formulae (V-1), (V-2), (V-3), and (V-4), wherein R3, R6 and R7 are as defined in Tables 1 to 5, and wherein R20 is methyl or ethyl. D. compounds of formulae (VI-1), (VI-2), (VI-3), and (VI-4), wherein R1, R2 and R3 are as defined in Tables 1 to 5 respectively; and wherein R20 is methyl or ethyl. E. compounds of formulae (VIII-1), (VIII-2), (VIII-3), and (VIII-4), wherein R3 is as defined in Tables 1 to 5 respectively; and wherein R20 is methyl and R21 is methyl or ethyl; or R20 is ethyl and R21 is methyl or ethyl. F. compounds of formulae (XIII-1), (XIII-2), (XIII-3), and (XIII-4), wherein R1, R2 and R3 are as defined in Tables 1 to 5 respectively. G. compounds of formulae (XIV-1), (XIV-2), (XIV-3), and (XIV-4), wherein R1, R2 and R3 are as defined in Tables 1 to 5 respectively, and wherein R21 is methyl or ethyl. 5 H. compounds of formulae (XV-1), (XV-2), (XV-3) and (XV-4), wherein R1, R2 and R3 are as defined in Tables 1 to 5. I. compounds of formula (II-5), wherein X, Y, Z, R3, R6, and R7 are as defined as in Table 5. compounds of formula (IV-5), wherein X, Y, Z, R3, R6, and R7 are as defined as in Table 5, and wherein G is halogen or Gi to G4. (IV-5) K. compounds of formula (V-5), wherein X, Y, Z, R3, R6, and R7 are as defined as in Table 5, and wherein R20 is methyl or ethyl. 5 L. compounds of formula (VI-5), wherein X, Y, Z, and R3 are as defined as in Table 5, and wherein R20 is methyl or ethyl. O (VI-5) M. compounds of formula (VIII-5), wherein X, Y, Z, and R3 are as defined as in Table 5, and wherein R20 is methyl and R21 is methyl or ethyl; or R20 is ethyl and R21 is methyl or ethyl. 10 N. compounds of formula (XIII-5), wherein X, Y, Z, R1 and R3 are as defined as in Table 5. O. compounds of formula (XIV-5), wherein X, Y, Z, R1 and R3 are as defined as in Table 5, and wherein R21 is methyl or ethyl. O                  O The compounds of formula (I) according to the invention are preventively and / or curatively valuable active ingredients in the field of pest control, even at low rates of application, which have a very favorable biocidal spectrum and are well tolerated by warm-blooded species, fish and plants. The active ingredients according to the invention act against all or individual developmental stages of normally sensitive, but also resistant, animal pests, such as insects or representatives of the order Acarina. The insecticidal or acaricidal activity of the active ingredients according to the invention can manifest itself directly, i. e. in destruction of the pests, which takes place either immediately or only after some time has elapsed, for example during ecdysis, or indirectly, for example in a reduced oviposition and / or hatching rate. Examples of the above mentioned animal pests are: from the order Acarina, for example, Acalitus spp, Aculus spp, Acaricalus spp, Aceria spp, Acarus siro, Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia spp, Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides spp, Eotetranychus spp, Eriophyes spp., Hemitarsonemus spp, Hyalomma spp., Ixodes spp., Olygonychus spp, Ornithodoros spp., Polyphagotarsone latus, Panonychus spp., Phyllocoptruta oleivora, Phytonemus spp, Polyphagotarsonemus spp, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Steneotarsonemus spp, Tarsonemus spp. and Tetranychus spp.; from the order Anoplura, for example, Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp. and Phylloxera spp.; from the order Coleoptera, for example, Agriotes spp., Amphimallon majale, Anomala orientalis, Anthonomus spp., Aphodius spp, Astylus atromaculatus, Ataenius spp, Atomaria linearis, Chaetocnema tibialis, Cerotoma spp, Conoderus spp, Cosmopolites spp., Cotinis nitida, Curculio spp., Cyclocephala spp, Dermestes spp., Diabrotica spp., Diloboderus abderus, Epilachna spp., Eremnus spp., Heteronychus arator, Hypothenemus hampei, Lagria vilosa, Leptinotarsa decemlineata, Lissorhoptrus spp., Liogenys spp, Maecolaspis spp, Maladera castanea, Megascelis spp, Meligethes aeneus, Melolontha spp., Myochrous armatus, Orycaephilus spp., Otiorhynchus spp., Phyllophaga spp, Phlyctinus spp., Popillia spp., Psylliodes spp., Rhyssomatus aubtilis, Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Somaticus spp, Sphenophorus spp, Sternechus subsignatus, Tenebrio spp., Tribolium spp. and Trogoderma spp.; from the order Diptera, for example, Aedes spp., Anopheles spp, Antherigona soccata.Bactrocea oleae, Bibio hortulanus, Bradysia spp, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Delia spp, Drosophila melanogaster, Fannia spp., Gastrophilus spp., Geomyza tripunctata, Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Rhagoletis spp, Rivelia quadrifasciata, Scatella spp, Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. and Tipula spp.; from the order Hemiptera, for example, Acanthocoris scabrator, Acrosternum spp, Adelphocoris lineolatus, Aleurodes spp., Amblypelta nitida, Bathycoelia thalassina, Blissus spp, Cimexspp., Clavigralla tomentosicollis, Creontiades spp, Distantiella theobroma, Dichelops furcatus, Dysdercus spp., Edessa spp, Euchistus spp., Eurydema pulchrum, Eurygaster spp., Halyomorpha halys, Horcias nobilellus, Leptocorisa spp., Lygus spp, Margarodes spp, Murgantia histrionic, Neomegalotomus spp, Nesidiocoris tenuis, Nezara spp., Nysius simulans, Oebalus insularis, Piesma spp., Piezodorus spp, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophara spp., Thyanta spp, Triatoma spp., Vatiga illudens; Acyrthosium pisum, Adalges spp, Agalliana ensigera, Agonoscena targionii, Aleurodicus spp, Aleurocanthus spp, Aleurolobus barodensis, Aleurothrixus floccosus, Aleyrodes brassicae, Amarasca biguttula, Amritodus atkinsoni, Aonidiella spp., Aphididae, Aphis spp., Aspidiotus spp., Aulacorthum solani, Bactericera cockerelli, Bemisia spp, Brachycaudus spp, Brevicoryne brassicae, Cacopsylla spp, Cavariella aegopodii Scop., Ceroplasterspp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Cicadella spp, Cofana spectra, Cryptomyzus spp, Cicadulina spp, Coccus hesperidum, Dalbulus maidis, Dialeurodes spp, Diaphorina citri, Diuraphis noxia, Dysaphis spp, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Glycaspis brimblecombei, Hyadaphis pseudobrassicae, Hyalopterus spp, Hyperomyzus pallidus, Idioscopus clypealis, Jacobiasca lybica, Laodelphax spp., Lecanium corni, Lepidosaphes spp., Lopaphis erysimi, Lyogenys maidis, Macrosiphum spp., Mahanarva spp, Metcalfa pruinosa, Metopolophium dirhodum, Myndus crudus, Myzus spp., Neotoxoptera sp, Nephotettix spp., Nilaparvata spp., Nippolachnus piri Mats, Odonaspis ruthae, Oregma lanigera Zehnter, Parabemisia myricae, Paratrioza cockerelli, Parlatoria spp., Pemphigus spp., Peregrinus maidis, Perkinsiella spp, Phorodon humuli, Phylloxera spp, Pianococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Pseudatomoscelis seriatus, Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Quesada gigas, Recilia dorsalis, Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Sogatella furcifera, Spissistilus festinus, Tarophagus Proserpina, Toxoptera spp, Trialeurodes spp, Tridiscus sporoboli, Trionymus spp, Trioza erytreae, Unaspis citri, Zygina flammigera, Zyginidia scutellaris, ; from the order Hymenoptera, for example, Acromyrmex, Arge spp, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprion spp., Pogonomyrmex spp, Slenopsis invicta, Solenopsis spp. and Vespa spp.; from the order Isoptera, for example, Coptotermes spp, Corniternes cumulans, Incisitermes spp, Macrotermes spp, Mastotermes spp, Microtermes spp, Reticulitermes spp.; Solenopsis geminate from the order Lepidoptera, for example, Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyresthia spp, Argyrotaenia spp., Autographa spp., Bucculatrix thurberiella, Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Chrysoteuchia topiaria, Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Colias lesbia, Cosmophila flava, Crambus spp, Crocidolomia binotalis, Cryptophlebia leucotreta, Cydalima perspectalis, Cydia spp., Diaphania perspectalis, Diatraea spp., Diparopsis castanea, Earias spp., Elasmopalpus lignosellus, Eldana saccharina, Ephestia spp., Epinotia spp, Estigmene acrea, Etiella zinckinella, Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia jaculiferia, Grapholita spp., Hedya nubiferana, Heliothis spp., Hellula undalis, Herpetogramma spp, Hyphantria cunea, Keiferia lycopersicella, Lasmopalpus lignosellus, Leucoptera scitella, Lithocollethis spp., Lobesia botrana, Loxostege bifidalis, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Mythimna spp, Noctua spp, Operophtera spp., Orniodes indica, Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Papaipema nebris, Pectinophora gossypiela, Perileucoptera coffeella, Pseudaletia unipuncta, Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylostella, Prays spp., Pseudoplusia spp, Rachiplusia nu, Richia albicosta, Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodoptera spp., Sylepta derogate, Synanthedon spp., Thaumetopoea spp., Tortrixspp., Trichoplusia ni, Tuta absoluta, and Yponomeuta spp.; from the order Mallophaga, for example, Damalinea spp. and Trichodectes spp.; from the order Orthoptera, for example, Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Neocurtilla hexadactyla, Periplaneta spp., Scapteriscus spp, and Schistocerca spp.; from the order Psocoptera, for example, Liposcelis spp.; from the order Siphonaptera, for example, Ceratophyllus spp., Ctenocephalides spp. and Xenopsylla cheopis; from the order Thysanoptera, for example, Calliothrips phaseoli, Frankliniella spp., Heliothrips spp, Hercinothrips spp., Parthenothrips spp, Scirtothrips aurantii, Sericothrips variabilis, Taeniothrips spp., Thrips spp; from the order Thysanura, for example, Lepisma saccharina. In a further aspect, the invention may also relate to a method of controlling damage to plant and parts thereof by plant parasitic nematodes (Endoparasitic-, Semiendoparasitic- and Ectoparasitic nematodes), especially plant parasitic nematodes such as root knot nematodes, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica, Meloidogyne arenaria and other Meloidogyne species; cyst-forming nematodes, Globodera rostochiensis and other Globodera species; Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; Seed gall nematodes, Anguina species; Stem and foliar nematodes, Aphelenchoides species; Sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; Pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; Ring nematodes, Criconema species, Criconemella species, Criconemoides species, Mesocriconema species; Stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci and other Ditylenchus species; Awl nematodes, Dolichodorus species; Spiral nematodes, Heliocotylenchus multicinctus and other Helicotylenchus species; Sheath and sheathoid nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; Lance nematodes, Hoploaimus species; false rootknot nematodes, Nacobbus species; Needle nematodes, Longidorus elongatus and other Longidorus species; Pin nematodes, Pratylenchus species; Lesion nematodes, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus curvitatus, Pratylenchus goodeyi and other Pratylenchus species; Burrowing nematodes, Radopholus similis and other Radopholus species; Reniform nematodes, Rotylenchus robustus, Rotylenchus reniformis and other Rotylenchus species; Scutellonema species; Stubby root nematodes, Trichodorus primitivus and other Trichodorus species, Paratrichodorus species; Stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species; Citrus nematodes, Tylenchulus species; Dagger nematodes, Xiphinema species; and other plant parasitic nematode species, such as Subanguina spp., Hypsoperine spp., Macroposthonia spp., Melinius spp., Punctodera spp., and Quinisulcius spp.. The compounds of the invention may also have activity against the molluscs. Examples of which include, for example, Ampullariidae; Arion (A. ater, A. circumscriptus, A. hortensis, A. rufus); Bradybaenidae (Bradybaena fruticum); Cepaea (C. hortensis, C. Nemoralis); ochlodina; Deroceras (D. agrestis, D. empiricorum, D. laeve, D. reticulatum); Discus (D. rotundatus); Euomphalia; Galba (G.trunculata); Helicelia (H. itala, H. obvia); Helicidae Helicigona arbustorum); Helicodiscus; Helix (H. aperta); Limax (L. cinereoniger, L. flavus, L. marginatus, L. maximus, L. tenellus); Lymnaea; Milax (M. gagates, M. marginatus, M. sowerbyi); Opeas; Pomacea (P. canaticulata); Vallonia and Zanitoides. The active ingredients according to the invention can be used for controlling, i. e. containing or destroying, pests of the abovementioned type which occur in particular on plants, especially on useful plants and ornamentals in agriculture, in horticulture and in forests, or on organs, such as fruits, flowers, foliage, stalks, tubers or roots, of such plants, and in some cases even plant organs which are formed at a later point in time remain protected against these pests. Suitable target crops are, in particular, cereals, such as wheat, barley, rye, oats, rice, maize or sorghum; beet, such as sugar or fodder beet; fruit, for example pomaceous fruit, stone fruit or soft fruit, such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries or blackberries; leguminous crops, such as beans, lentils, peas or soya; oil crops, such as oilseed rape, mustard, poppies, olives, sunflowers, coconut, castor, cocoa or ground nuts; cucurbits, such as pumpkins, cucumbers or melons; fibre plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruit or tangerines; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes or bell peppers; Lauraceae, such as avocado, Cinnamonium or camphor; and also tobacco, nuts, coffee, eggplants, sugarcane, tea, pepper, grapevines, hops, the plantain family and latex plants. In a particular embodiment, a compound of the formula (I) can control mites, rust mites and spider mites in crops, tress, and plants selected from vegetables (especially tomatoes and cucurbits), citrus, pome fruits, stone fruit, tree nuts, cotton, tropical crops, avocados, ornamentals, beans, soybean, strawberry, and grapes. The compositions and / or methods of the present invention may be also used on any ornamental and / or vegetable crops, including flowers, shrubs, broad-leaved trees and evergreens. For example the invention may be used on any of the following ornamental species: Ageratum spp., Alonsoa spp., Anemone spp., Anisodontea capsenisis, Anthemis spp., Antirrhinum spp., Aster spp., Begonia spp. (e.g. B. elatior, B. semperflorens, B. tubereux), Bougainvillea spp., Brachycome spp., Brassica spp. (ornamental), Calceolaria spp., Capsicum annuum, Catharanthus roseus, Canna spp., Centaurea spp., Chrysanthemum spp., Cineraria spp. (C. maritime), Coreopsis spp., Crassula coccinea, Cuphea ignea, Dahlia spp., Delphinium spp., Dicentra spectabilis, Dorotheantus spp., Eustoma grandiflorum, Forsythia spp., Fuchsia spp., Geranium gnaphalium, Gerbera spp., Gomphrena globosa, Heliotropium spp., Helianthus spp., Hibiscus spp., Hortensia spp., Hydrangea spp., Hypoestes phyllostachya, Impatiens spp. ( / . Walleriana), Iresines spp., Kalanchoe spp., Lantana camara, Lavatera trimestris, Leonotis leonurus, Lilium spp., Mesembryanthemum spp., Mimulus spp., Monarda spp., Nemesia spp., Tagetes spp., Dianthus spp. (carnation), Canna spp., Oxalis spp., Bellis spp., Pelargonium spp. (P. peltatum, P. Zonaie), Viola spp. (pansy), Petunia spp., Phlox spp., Plecthranthus spp., Poinsettia spp., Parthenocissus spp. (P. quinquefolia, P. tricuspidata), Primula spp., Ranunculus spp., Rhododendron spp., Rosa spp. (rose), Rudbeckia spp., Saintpaulia spp., Salvia spp., Scaevola aemola, Schizanthus wisetonensis, Sedum spp., Solanum spp., Surfinia spp., Tagetes spp., Nicotinia spp., Verbena spp., Zinnia spp. and other bedding plants. For example the invention may be used on any of the following vegetable species: Allium spp. (A sativum, A., cepa, A. oschaninii, A. Porrum, A. ascalonicum, A. fistulosum), Anthriscus cerefolium, Apium graveolus, Asparagus officinalis, Beta vulgarus, Brassica spp. (B. Oleracea, B. Pekinensis, B. rapa), Capsicum annuum, Cicer arietinum, Cichorium endivia, Cichorum spp. (C. intybus, C. endivia), Citrillus lanatus, Cucumis spp. (C. sativus, C. meld), Cucurbita spp. (C. pepo, C. maxima), Cyanara spp. (C. scolymus, C. carduncuius), Daucus carota, Foeniculum vulgare, Hypericum spp., Lactuca sativa, Lycopersicon spp. (L. esculentum, L. lycopersicum), Mentha spp., Ocimum basilicum, Petroselinum crispum, Phaseolus spp. (P. vulgaris, P. coccineus), Pisum sativum, Raphanus sativus, Rheum rhaponticum, Rosemarinus spp., Salvia spp., Scorzonera hispanica, Solanum melongena, Spinacea oleracea, Valerianella spp. (1 / . locusta, V. eriocarpa) and Vicia faba. Preferred ornamental species include African violet, Begonia, Dahlia, Gerbera, Hydrangea, Verbena, Rosa, Kalanchoe, Poinsettia, Aster, Centaurea, Coreopsis, Delphinium, Monarda, Phlox, Rudbeckia, Sedum, Petunia, Viola, Impatiens, Geranium, Chrysanthemum, Ranunculus, Fuchsia, Salvia, Hortensia, rosemary, sage, St. Johnswort, mint, sweet pepper, tomato and cucumber. The compounds of formula (I) may be particularly suitable for control of mites, spider mites and rust mites, for example, Acarapis spp; Acarapis woodi; Acarus siro; Acarus spp; Aceria sheldoni; Aculops pelekassi; Aculops spp; Aculus schlechtendali; Aculus spp; Amblyseius fallacis; Brevipalpus spp; Brevipalpus phoenicis; Bryobia praetiosa; Bryobia rubrioculus; Caloglyphus spp; Cheyletiella blakei; Cheyletiella spp; Cheyletiella yasguri; Chorioptes bovis; Chorioptes spp; Cytodites spp; Demodex bovis; Demodex caballi; Demodex canis; Demodex caprae; Demodex equi; Demodex ovis; Demodex spp; Demodex suis; Dermanyssus gallinae; Dermanyssus spp; Eotetranychus spp; Eotetranychus willamettei; Epitrimerus pyri; Eriophyes ribis; Eriophyes spp; Eriophyes vitis; Eutetranychus spp; Halotydeus destructor; Hemitarsonemus spp; Knemidocoptes spp; Laminosioptes spp; Listrophorus spp; Myobia spp; Neoschongastia xerothermobia; Neotrombicula autumnalis; Neotrombicula desaleri; Notoedres cati; Notoedres spp; Oligonychus coffeae; Oligonychus ilicis; Oligonychus spp; Ornithocheyletia spp; Ornithonyssus bursa; Ornithonyssus spp; Ornithonyssus sylviarum; Otodectes cynotis; Otodectes spp; Panonychus citri; Panonychus spp; Panonychus ulmi; Phyllocoptruta oleivora; Phyllocoptruta spp.; Phytoseiulus spp.; Pneumonyssoides caninum; Polyphagotarsonemus latus; Polyphagotarsonemus spp; Psorergates ovis; Psorergates spp; Psoroptes cuniculi; Psoroptes equi; Psoroptes ovis; Psoroptes spp; Pterolichus spp; Raillietia spp; Rhizoglyphus spp; Sarcoptes bovis; Sarcoptes canis; Sarcoptes caprae; Sarcoptes equi; Sarcoptes ovis; Sarcoptes rupicaprae; Sarcoptes spp; Sarcoptes suis; Steneotarsonemus spinki; Steneotarsonemus spp; Sternostoma spp; Tarsonemus spp; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp; Tetranychus urticae; Trombicula akamushi; Trombicula spp; Typhlodromus occidentalis; Tyrophagus spp; Varroa jacobsoni; Varroa spp; Vasates lycopersici; and Zetzellia mali. In an embodiment, a compound of formula (I) may control one or more of: Aceria sheldoni ; Aculus lycopersici; Aculus pelekassi; Aculus schlechtendali; Brevipalpus phoenicis; Brevipalpus spp.; Bryobia rubrioculus; Eotetranychus carpini; Eotetranychus spp.; Epitrimerus pyri; Eriophyes piri; Eriophyes spp.; Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus citri; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp.; and Tetranychus urticae. In a further embodiment, a compound of formula (I) may especially suitable for controlling one or more of: Aceria sheldoni; Aculus pelekassi; Brevipalpus phoenicis; Brevipalpus spp.; Eriophyes piri; Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp.; and Tetranychus urticae. The term "crops" is to be understood as including also crop plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria, especially those of the genus Bacillus. Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins, for example insecticidal proteins from Bacillus cereus or Bacillus popilliae; or insecticidal proteins from Bacillus thuringiensis, such as 8-endotoxins, e.g. CrylAb, CrylAc, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), e.g. Vip1, Vip2, Vip3 or Vip3A; or insecticidal proteins of bacteria colonising nematodes, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectins, barley lectins or snowdrop lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroidoxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers, such as blockers of sodium or calcium channels, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases. In the context of the present invention there are to be understood by 8-endotoxins, for example CrylAb, CrylAc, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 orCry9C, or vegetative insecticidal proteins (Vip), for example Vip1, Vip2, Vip3 or Vip3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are produced recombinantly by a new combination of different domains of those proteins (see, for example, WO 02 / 15701). Truncated toxins, for example a truncated CrylAb, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are replaced. In such amino acid replacements, preferably non-naturally present protease recognition sequences are inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G-recognition sequence is inserted into a Cry3A toxin (see WO 03 / 018810). Examples of such toxins or transgenic plants capable of synthesising such toxins are disclosed, for example, in EP-A-0 374 753, WO 93 / 07278, WO 95 / 34656, EP-A-0 427 529, EP-A-451 878 and WO 03 / 052073. The processes for the preparation of such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. Cryl-type deoxyribonucleic acids and their preparation are known, for example, from WO 95 / 34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90 / 13651. The toxin contained in the transgenic plants imparts to the plants tolerance to harmful insects. Such insects can occur in any taxonomic group of insects, but are especially commonly found in the beetles (Coleoptera), two-winged insects (Diptera) and moths (Lepidoptera). Transgenic plants containing one or more genes that code for an insecticidal resistance and express one or more toxins are known and some of them are commercially available. Examples of such plants are: YieldGard® (maize variety that expresses a CrylAb toxin); YieldGard Rootworm® (maize variety that expresses a Cry3Bb1 toxin); YieldGard Plus® (maize variety that expresses a CrylAb and a Cry3Bb1 toxin); Starlink® (maize variety that expresses a Cry9C toxin); Herculex I® (maize variety that expresses a Cry1Fa2 toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (cotton variety that expresses a CrylActoxin); Bollgard I® (cotton variety that expresses a CrylAc toxin); Bollgard II® (cotton variety that expresses a CrylAc and a Cry2Ab toxin); VipCot® (cotton variety that expresses a Vip3A and a CrylAb toxin); NewLeaf® (potato variety that expresses a Cry3A toxin); NatureGard®, Agrisure® GT Advantage (GA21 glyphosate-tolerant trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait) and Protecta®. Further examples of such transgenic crops are: 1. Bt11 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a truncated CrylAb toxin. Bt11 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium. 2. Bt176 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a CrylAb toxin. Bt176 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium. 3. MIR604 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. Maize which has been rendered insect-resistant by transgenic expression of a modified Cry3A toxin. This toxin is Cry3A055 modified by insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03 / 018810. 4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / DE / 02 / 9. MON 863 expresses a Cry3Bb1 toxin and has resistance to certain Coleoptera insects. 5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / ES / 96 / 02. 6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium, registration number C / NL / 00 / 10. Genetically modified maize for the expression of the protein Cry1F for achieving resistance to certain Lepidoptera insects and of the PAT protein for achieving tolerance to the herbicide glufosinate ammonium. 7. NK603 x MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / GB / 02 / M3 / 03. Consists of conventionally bred hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. NK603 x MON 810 Maize transgenically expresses the protein CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which imparts tolerance to the herbicide Roundup® (contains glyphosate), and also a CrylAb toxin obtained from Bacillus thuringiensis subsp. kurstaki which brings about tolerance to certain Lepidoptera, include the European corn borer. Transgenic crops of insect-resistant plants are also described in BATS (Zentrum fur Biosicherheit und Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http: / / bats.ch). The term "crops" is to be understood as including also crop plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising antipathogenic substances having a selective action, such as, for example, the so-called "pathogenesis-related proteins" (PRPs, see e.g. EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants capable of synthesising such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95 / 33818 and EP-A-0 353 191. The methods of producing such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. Crops may also be modified for enhanced resistance to fungal (for example Fusarium, Anthracnose, or Phytophthora), bacterial (for example Pseudomonas) or viral (for example potato leafroll virus, tomato spotted wilt virus, cucumber mosaic virus) pathogens. Crops also include those that have enhanced resistance to nematodes, such as the soybean cyst nematode. Crops that are tolerance to abiotic stress include those that have enhanced tolerance to drought, high salt, high temperature, chill, frost, or light radiation, for example through expression of NF-YB or other proteins known in the art. Antipathogenic substances which can be expressed by such transgenic plants include, for example, ion channel blockers, such as blockers for sodium and calcium channels, for example the viral KP1, KP4 or KP6 toxins; stilbene synthases; bibenzyl synthases; chitinases; glucanases; the so-called "pathogenesis-related proteins" (PRPs; see e.g. EP-A-0 392 225); antipathogenic substances produced by microorganisms, for example peptide antibiotics or heterocyclic antibiotics (see e.g. WO95 / 33818) or protein or polypeptide factors involved in plant pathogen defence (so-called "plant disease resistance genes", as described in WO03 / 000906). Further areas of use of the compositions according to the invention are the protection of stored goods and store rooms and the protection of raw materials, such as wood, textiles, floor coverings or buildings, and also in the hygiene sector, especially the protection of humans, domestic animals and productive livestock against pests of the mentioned type. The present invention provides a compound of the first aspect for use in therapy. The present invention provides a compound of the first aspect, for use in controlling parasites in or on an animal. The present invention further provides a compound of the first aspect, for use in controlling ectoparasites on an animal. The present invention further provides a compound of the first aspect, for use in preventing and / or treating diseases transmitted by ectoparasites. The present invention provides the use of a compound of the first aspect, for the manufacture of a medicament for controlling parasites in or on an animal. The present invention further provides the use of a compound of the first aspect, for the manufacture of a medicament for controlling ectoparasites on an animal. The present invention further provides the use of a compound of the first aspect, for the manufacture of a medicament for preventing and / or treating diseases transmitted by ectoparasites. The present invention provides the use of a compound of the first aspect, in controlling parasites in or on an animal. The present invention further provides the use of a compound of the first aspect, in controlling ectoparasites on an animal. The term "controlling" when used in context of parasites in or on an animal refers to reducing the number of pests or parasites, eliminating pests or parasites and / or preventing further pest or parasite infestation. The term "treating" when used used in context of parasites in or on an animal refers to restraining, slowing, stopping or reversing the progression or severity of an existing symptom or disease. The term "preventing" when used used in context of parasites in or on an animal refers to the avoidance of a symptom or disease developing in the animal. The term "animal" when used used in context of parasites in or on an animal may refer to a mammal and a non-mammal, such as a bird orfish. In the case of a mammal, it may be a human or non-human mammal. Non-human mammals include, but are not limited to, livestock animals and companion animals. Livestock animals include, but are not limited to, cattle, camellids, pigs, sheep, goats and horses. Companion animals include, but are not limited to, dogs, cats and rabbits. A "parasite" is a pest which lives in or on the host animal and benefits by deriving nutrients at the host animal's expense. An "endoparasite" is a parasite which lives in the host animal. An "ectoparasite" is a parasite which lives on the host animal. Ectoparasites include, but are not limited to, acari, insects and crustaceans (e.g. sea lice). The Acari (or Acarina) sub-class comprises ticks and mites. Ticks include, but are not limited to, members of the following genera: Rhipicaphalus, for example, Rhipicaphalus (Boophilus) microplus and Rhipicaphalus sanguineus; Amblyomrna; Dermacentor, Haemaphysalis; Hyalomma; Ixodes; Rhipicentor; Margaropus; Argas; Otobius; and Omithodoros. Mites include, but are not limited to, members of the following genera: Chorioptes, for example Chorioptes bovis; Psoroptes, for example Psoroptes ovis; Cheyletiella; Dermanyssus; for example Dermanyssus gallinae; Ortnithonyssus; Demodex, for example Demodex canis; Sarcoptes, for example Sarcoptes scabiei; and Psorergates. Insects include, but are not limited to, members of the orders: Siphonaptera, Diptera, Phthiraptera, Lepidoptera, Coleoptera and Homoptera. Members of the Siphonaptera order include, but are not limited to, Ctenocephalides fells and Ctenocephatides canis. Members of the Diptera order include, but are not limited to, Musca spp.; bot fly, for example Gasterophilus intestinalis and Oestrus ovis; biting flies; horse flies, for example Haematopota spp. and Tabunus spp.; haematobia, for example haematobia irritans; Stomoxys; Lucilia; midges; and mosquitoes. Members of the Phthiraptera class include, but are not limited to, blood sucking lice and chewing lice, for example Bovicola Ovis and Bovicola Bovis. The term "effective amount" when used used in context of parasites in or on an animal refers to the amount or dose of the compound of the invention, or a salt thereof, which, upon single or multiple dose administration to the animal, provides the desired effect in or on the animal. The effective amount can be readily determined by the attending diagnostician, as one skilled in the art, by the use of known techniques and by observing results obtained under analogous circumstances. In determining the effective amount a number of factors are considered by the attending diagnostician, including, but not limited to: the species of mammal; its size, age, and general health; the parasite to be controlled and the degree of infestation; the specific disease or disorder involved; the degree of or involvement or the severity of the disease or disorder; the response of the individual; the particular compound administered; the mode of administration; the bioavailability characteristics of the preparation administered; the dose regimen selected; the use of concomitant medication; and other relevant circumstances. The compounds of the invention may be administered to the animal by any route which has the desired effect including, but not limited to topically, orally, parenterally' and subcutaneously. Topical administration is preferred. Formulations suitable for topical administration include, for example, solutions, emulsions and suspensions and may take the form of a pour-on, spot-on, spray-on, spray race or dip. In the alternative, the compounds of the invention may be administered by means of an ear tag or collar. Salt forms of the compounds of the invention include both pharmaceutically acceptable salts and veterinary acceptable salts, which can be different to agrochemically acceptable salts. Pharmaceutically and veterinary acceptable salts and common methodology for preparing them are well known in the art. See, for example, Gould, P.L., "Salt selection for basic drugs", International Journal of Pharmaceutics, 33: 201 -217 (1986); Bastin, R.J., et al. "Salt Selection and Optimization Procedures for Pharmaceutical New Chemical Entities", Organic Process Research and Development, 4: 427-435 (2000); and Berge, S.M., et al., "Pharmaceutical Salts", Journal of Pharmaceutical Sciences, 66: 1-19, (1977). One skilled in the art of synthesis will appreciate that the compounds of the invention are readily converted to and may be isolated as a salt, such as a hydrochloride salt, using techniques and conditions well known to one of ordinary skill in the art. In addition, one skilled in the art of synthesis will appreciate that the compounds of the invention are readily converted to and may be isolated as the corresponding free base from the corresponding salt. The present invention may also provide a method for controlling pests (such as mosquitoes and other disease vectors; see also http: / / www.who.int / malaria / vector_control / irs / en / ). In one embodiment, the method for controlling pests comprises applying the compositions of the invention to the target pests, to their locus or to a surface or substrate by brushing, rolling, spraying, spreading or dipping. By way of example, an IRS (indoor residual spraying) application of a surface such as a wall, ceiling or floor surface is contemplated by the method of the invention. In another embodiment, it is contemplated to apply such compositions to a substrate such as non-woven or a fabric material in the form of (or which can be used in the manufacture of) netting, clothing, bedding, curtains and tents. In one embodiment, the method for controlling such pests comprises applying a pesticidally effective amount of the compositions of the invention to the target pests, to their locus, or to a surface or substrate so as to provide effective residual pesticidal activity on the surface or substrate. Such application may be made by brushing, rolling, spraying, spreading or dipping the pesticidal composition of the invention. By way of example, an IRS application of a surface such as a wall, ceiling or floor surface is contemplated by the method of the invention so as to provide effective residual pesticidal activity on the surface. In another embodiment, it is contemplated to apply such compositions for residual control of pests on a substrate such as a fabric material in the form of (or which can be used in the manufacture of) netting, clothing, bedding, curtains and tents. Substrates including non-woven, fabrics or netting to be treated may be made of natural fibres such as cotton, raffia, jute, flax, sisal, hessian, or wool, or synthetic fibres such as polyamide, polyester, polypropylene, polyacrylonitrile or the like. The polyesters are particularly suitable. The methods of textile treatment are known, e.g. WO2008 / 151984, WO2003 / 034823, US5631072, WO2005 / 64072, WO2006 / 128870, EP 1724392, WO2005113886 or WO2007 / 090739. Further areas of use of the compositions according to the invention may be the field of tree injection / trunk treatment for all ornamental trees as well all sort of fruit and nut trees. In the field of tree injection / trunk treatment, the compounds according to the present invention may be especially suitable against wood-boring insects from the order Lepidoptera as mentioned above and from the order Coleoptera, especially against woodborers listed in the following tables A and B: Table A. Examples of exotic woodborers of economic importance. Family Species Host or Crop Infested Buprestidae Agrilus planipennis Ash Cerambycidae Anoplura glabripennis Hardwoods Scolytidae Xylosandrus crassiusculus Hardwoods X. mutilatus Hardwoods Tomicus piniperda Conifers Table B. Examples of native woodborers of economic importance. Family Species Host or Crop Infested Buprestidae Agrilus anxius Birch Agrilus politus Willow, Maple Agrilus sayi Bayberry, Sweetfern Agrilus vittaticolllis Apple, Pear, Cranberry, Serviceberry, Hawthorn Chrysobothris femorata Apple, Apricot, Beech, Boxelder, Cherry, Chestnut, Currant, Elm, Hawthorn, Hackberry, Hickory, Horsechestnut, Linden, Maple, Mountain-ash, Oak, Pecan, Pear, Peach, Persimmon, Plum, Poplar, Quince, Redbud, Serviceberry, Sycamore, Walnut, Willow Texania campestris Basswood, Beech, Maple, Oak, Sycamore, Willow, Yellow-poplar Cerambycidae Goes pulverulentus Beech, Elm, Nuttall, Willow, Black oak, Cherrybark oak, Water oak, Sycamore Goes tigrinus Oak Neoclytus acuminatus Ash, Hickory, Oak, Walnut, Birch, Beech, Maple, Eastern hophornbeam, Dogwood, Persimmon, Redbud, Holly, Hackberry, Black locust, Honeylocust, Yellow-poplar, Chestnut, Osage-orange, Sassafras, Lilac, Mountain-mahogany, Pear, Cherry, Plum, Peach, Apple, Elm, Basswood, Sweetgum Neoptychodes trilineatus Fig, Alder, Mulberry, Willow, Netleaf hackberry Oberea ocellata Sumac, Apple, Peach, Plum, Pear, Currant, Blackberry Oberea tripunctata Dogwood, Viburnum, Elm, Sourwood, Blueberry, Rhododendron, Azalea, Laurel, Poplar, Willow, Mulberry Oncideres cingulata Hickory, Pecan, Persimmon, Elm, Sourwood, Basswood, Honeylocust, Dogwood, Eucalyptus, Oak, Hackberry, Maple, Fruit trees Family Species Host or Crop Infested Saperda calcarata Poplar Strophiona nitens Chestnut, Oak, Hickory, Walnut, Beech, Maple Scolytidae Corthylus columbianus Maple, Oak, Yellow-poplar, Beech, Boxelder, Sycamore, Birch, Basswood, Chestnut, Elm Dendroctonus frontalis Pine Dryocoetes betulae Birch, Sweetgum, Wild cherry, Beech, Pear Monarthrum fasciatum Oak, Maple, Birch, Chestnut, Sweetgum, Blackgum, Poplar, Hickory, Mimosa, Apple, Peach, Pine Phloeotribus liminaris Peach, Cherry, Plum, Black cherry, Elm, Mulberry, Mountain-ash Pseudopityophthorus pruinosus Oak, American beech, Black cherry, Chickasaw plum, Chestnut, Maple, Hickory, Hornbeam, Hophornbeam Sesiidae Paranthrene simulans Oak, American chestnut Sannina uroceriformis Persimmon Synanthedon exitiosa Peach, Plum, Nectarine, Cherry, Apricot, Almond, Black cherry Synanthedon pictipes Peach, Plum, Cherry, Beach, Black Cherry Synanthedon rubrofascia Tupelo Synanthedon scitula Dogwood, Pecan, Hickory, Oak, Chestnut, Beech, Birch, Black cherry, Elm, Mountain-ash, Viburnum, Willow, Apple, Loquat, Ninebark, Bayberry Vitacea polistiformis Grape The present invention may be also used to control any insect pests that may be present in turfgrass, including for example beetles, caterpillars, fire ants, ground pearls, millipedes, sow bugs, mites, mole crickets, scales, mealybugs, ticks, spittlebugs, southern chinch bugs and white grubs. The present 5 invention may be used to control insect pests at various stages of their life cycle, including eggs, larvae, nymphs and adults. In particular, the present invention may be used to control insect pests that feed on the roots of turfgrass including white grubs (such as Cyclocephala spp. (e.g. masked chafer, C. lurida), Rhizotrogus spp. (e.g. European chafer, R. majalis), Cotinus spp. (e.g. Green June beetle, C. nitida), Popillia spp. (e.g. Japanese 10 beetle, P.japonica), Phyllophaga spp. (e.g. May / June beetle), Ataenius spp. (e.g. Black turfgrass ataenius, A. spretulus), Maladera spp. (e.g. Asiatic garden beetle, M. castanea) and Tomarus spp.), ground pearls (Margarodes spp.), mole crickets (tawny, southern, and short-winged; Scapteriscus spp., Gryllotalpa africana) and leatherjackets (European crane fly, Tipula spp.). The present invention may also be used to control insect pests of turfgrass that are thatch dwelling, including armyworms (such as fall armyworm Spodoptera frugiperda, and common armyworm Pseudaletia unipuncta), cutworms, billbugs (Sphenophorus spp., such as S. venatus verstitus and S. parvulus), and sod webworms (such as Crambus spp. and the tropical sod webworm, Herpetogramma phaeopteralis). The present invention may also be used to control insect pests of turfgrass that live above the ground and feed on the turfgrass leaves, including chinch bugs (such as southern chinch bugs, B / issus insularis), Bermudagrass mite (Eriophyes cynodoniensis), rhodesgrass mealybug (Antonina graminis), two-lined spittlebug (Propsapia bicincta), leafhoppers, cutworms (Noctuidae family), and greenbugs. The present invention may also be used to control other pests of turfgrass such as red imported fire ants (Solenopsis invicta) that create ant mounds in turf. In the hygiene sector, the compositions according to the invention may be active against ectoparasites such as hard ticks, soft ticks, mange mites, harvest mites, flies (biting and licking), parasitic fly larvae, lice, hair lice, bird lice and fleas. Examples of such parasites are: Of the order Anoplurida: Haematopinus spp., Linognathus spp., Pediculus spp. and Phtirus spp., Solenopotes spp.. Of the order Mallophagida: Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp. and Felicola spp.. Of the order Diptera and the suborders Nematocerina and Brachycerina, for example Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp. and Melophagus spp.. Of the order Siphonapterida, for example Pulex spp., Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp.. Of the order Heteropterida, for example Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.. Of the order Blattarida, for example Blatta orientalis, Periplaneta americana, Blattelagermanica and Supella spp.. Of the subclass Acaria (Acarida) and the orders Meta- and Meso-stigmata, for example Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp. and Varroa spp.. Of the orders Actinedida (Prostigmata) and Acaridida (Astigmata), for example Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergatesspp., Demodexspp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp. and Laminosioptes spp.. The compositions according to the invention may also be suitable for protecting against insect infestation in the case of materials such as wood, textiles, plastics, adhesives, glues, paints, paper and card, leather, floor coverings and buildings. The compositions according to the invention can be used, for example, against the following pests: beetles such as Hylotrupes bajulus, Chlorophorus pilosis, Anobium punctatum, Xestobium rufovillosum, Ptilinuspecticornis, Dendrobium pertinex, Ernobius mollis, Priobium carpini, Lyctus brunneus, Lyctus africanus, Lyctus planicollis, Lyctus linearis, Lyctus pubescens, Trogoxylon aequale, Minthesrugicollis, Xyleborus spec.,Tryptodendron spec., Apate monachus, Bostrychus capucins, Heterobostrychus brunneus, Sinoxylon spec, and Dinoderus minutus, and also hymenopterans such as Sirex juvencus, Urocerus gigas, Urocerus gigas taignus and Urocerus augur, and termites such as Kalotermes flavicollis, Cryptotermes brevis, Heterotermes indicola, Reticulitermes flavipes, Reticulitermes santonensis, Reticulitermes lucifugus, Mastotermes darwiniensis, Zootermopsis nevadensis and Coptotermes formosanus, and bristletails such as Lepisma saccharina. The compounds of formulae I, 1-1, I-2, I-3, I-4, l-1a, l-2a, l-3a, and l-4a, or salts thereof, are especially suitable for controlling one or more pests selected from the genus: Spodoptera spp, Helicoverpa spp, Heliothis spp, Leucinodes spp, Tuta spp, Plutella spp, Cydia spp, Lobesia spp, Tortrixspp, Amyelois spp, Maruca spp, Chrysodeixis spp, Agrotis spp, Elasmopalpus spp, Dalbulus spp, Sternechus spp, Phyllotreta spp, Popillia spp, Scirpophaga spp, Chilo spp, Cnaphalocrosis spp, Tetranychus spp, Panonychus spp, Polyphagotarsonemus spp, Phyllocoptruta spp, Aculus spp, Brevipalpus spp, Oligonychus spp, Aculops spp, Nilaparvata spp, Sogatella spp, Laodelphax spp, Nephotettix spp, Diabrotica spp, Agriotes spp, Hypnoidus spp, Limonius spp, Melanotus spp, Conoderus spp, Delia spp, Amphimallon spp, Popillia spp, Euschistus spp, Piezodorus spp, Nezara spp, Dichelops spp, Lygus spp, Leptocorisa spp, Eurygasterspp, Halymorpha spp, Thrips spp, Scirtothrips spp, Frankliniella spp, Anthonomus spp, Melingethes spp, Phyllotreta spp, Leptinotarsa spp, Bemisia spp, Trialeurodes spp, Aphis spp, and Myzus spp. In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 5 and Table P ”) controls one or more of pests selected from the genus: Spodoptera spp, Helicoverpa spp, Heliothis spp, Leucinodes spp, Tuta spp, Plutella spp, Cydia spp, Lobesia spp, Tortrixspp, Amyelois spp, Maruca spp, Chrysodeixis spp, Agrotis spp, Elasmopalpus spp, Dalbulus spp, Sternechus spp, Phyllotreta spp, Popillia spp, Scirpophaga spp, Chilo spp, Cnaphalocrosis spp, Tetranychus spp, Panonychus spp, Polyphagotarsonemus spp, Phyllocoptruta spp, Aculus spp, Brevipalpus spp, Oligonychus spp, Aculops spp, Nilaparvata spp, Sogatella spp, Laodelphax spp, Nephotettix spp, Diabrotica spp, Agriotes spp, Hypnoidus spp, Limonius spp, Melanotus spp, Conoderus spp, Delia spp, Amphimallon spp, Popillia spp, Euschistus spp, Piezodorus spp, Nezara spp, Dichelops spp, Lygus spp, Leptocorisa spp, Eurygaster spp, Halymorpha spp, Thrips spp, Scirtothrips spp, Frankliniella spp, Anthonomus spp, Melingethes spp, Phyllotreta spp, Leptinotarsa spp, Bemisia spp, Trialeurodes spp, Aphis spp, and Myzus spp. The compounds of formulae I, 1-1, I-2, I-3, I-4, l-1a, l-2a, l-3a, and l-4a, or salts thereof, are especially suitable for controlling one or more pests selected from: Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis), Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrix spp, Maruca vitrata, Chrysodeixis includens, Agrotis ipsilon, Elasmopalpus lignosellus, Dalbulus maidis, Phyllotreta spp, Popillia japonica, Scirpophaga incertulas, Chilo suppressalis, Cnaphalocrosis medinalis, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Nilaparvata lugens, Sogatella frucifera, Laodelphax striatellus, Nephotettix spp, Diabrotica vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia radicum, Popillia japonica, Euschistus heros, Piezodorus lituratus, Nezara viridula, Dichelops furcatus, Lygus sp., Leptocorisa acuta, Halyomorpha halys, Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, and Myzus persicae. In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 5 and Table P ”) controls one or more of pests selected from the genus: Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis) + TX, Helicoverpa armigera + TX, Heliothis virescens + TX, Leucinodes orbonalis + TX, Tuta absoluta + TX, Plutella xylostella + TX, Cydia pomonella + TX, Lobesia spp + TX, Tortrix spp + TX, Maruca vitrata + TX, Chrysodeixis includens + TX, Agrotis ipsilon + TX, Elasmopalpus lignosellus + TX, Dalbulus maidis + TX, Phyllotreta spp + TX, Popillia japonica + TX, Scirpophaga incertulas + TX, Chilo suppressalis + TX, Cnaphalocrosis medinalis + TX, Tetranychus urticae + TX, Panonychus ulmi + TX, Polyphagotarsonemus latus + TX, Phyllocoptruta oleivora + TX Brevipalpus spp + TX, Aculops lycopersici + TX, Nilaparvata lugens + TX, Sogatella frucifera + TX, Laodelphax striatellus + TX, Nephotettix spp + TX, Diabrotica vigifera + TX, Agriotes spp + TX, Hypnoidus bicolor + TX, Limonius canus + TX, Delia radicum + TX, Popillia japonica + TX, Euschistus heros + TX, Piezodorus lituratus + TX, Nezara viridula + TX, Dichelops furcatus + TX, Lygus spp + TX, Leptocorisa acuta + TX, Halyomorpha haly + TX s, Thrips tabaci + TX, Scirtothrips dorsalis + TX, Frankliniella occidentalis + TX, Anthonomus grandis + TX, Meligethes aeneus + TX, Phyllotreta spp + TX, Leptinotarsa decemlineata + TX, Bemisia tabaci + TX, Trialeurodes vaporariorum + TX, Aphis gossypii + TX, and Myzus persicae + TX. The compounds of formulae I, 1-1, I-2, I-3, I-4, l-1a, l-2a, l-3a, and l-4a, or salts thereof, are especially suitable for controlling in the crops listed in the Table below the pests listed. Crop Pests leafy vegetables Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrix spp, Maruca vitrata, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici solanacea Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici brassica Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata okra Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata pome fruits Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici vegetables Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Myzus persicae grapes Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis nuts Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata plantation Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici eggplant Spodoptera spp, Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixspp, Maruca vitrata, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici corn Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis), Helicoverpa armigera, Heliothis virescens, Chrysodeixis includens, Agrotis ipsilon, Elasmopalpus lignosellus, Agrotis ipsilon, Dalbulus maidis, Phyllotreta sp., Popillia japonica, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Diabrotica virgifera vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia radicum, Euschistus heros, Piezodorus lituratus, Nezara viridula, Dichelops furcatus, Lygus spp, Leptocorisa acuta, Halyomorpha halys, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata soybean Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis), Helicoverpa armigera, Heliothis virescens, Chrysodeixis includens, Agrotis ipsilon, Elasmopalpus lignosellus, Agrotis ipsilon, Dalbulus maidis, Phyllotreta sp., Popillia japonica, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Euschistus heros, Piezodorus lituratus, Nezara viridula, Dichelops furcatus, Lygus spp, Leptocorisa acuta, Halyomorpha halys, Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata cotton Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis), Helicoverpa armigera, Heliothis virescens, Chrysodeixis includens, Agrotis ipsilon, Elasmopalpus lignosellus, Agrotis ipsilon, Dalbulus maidis, Phyllotreta sp., Popillia japonica, Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Diabrotica virgifera vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia radicum, Euschistus heros, Piezodorus lituratus, Nezara viridula, Dichelops furcatus, Lygus spp, Leptocorisa acuta, Halyomorpha halys, Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Myzus persicae canola Spodoptera frugiperda, Elasmopalpus lignosellus, Agrotis ipsilon, Dalbulus maidis, Phyllotreta spp, Popillia japonica rice Scirpophaga incertulas, Chilo suppressalis, Cnaphalocrosis medinalis, Nilaparvata lugens, Sogatella frucifera, Laodelphaxstriatellus, Nephotettixspp, Euschistus heros, Piezodorus lituratus, Nezara viridula, Dichelops furcatus, Lygus spp, Leptocorisa acuta, Halyomorpha halys, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata citrus Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis potato Tetranychus urticae, Panonychus ulmi, Polyphagotarsonemus latus, Phyllocoptruta oleivora, Brevipalpus spp, Aculops lycopersici, Diabrotica virgifera vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia radicum, Popillia japonica, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata Cereal (wheat, sorghum, barley) Diabrotica virgifera vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia radicum, Popillia japonica, Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata diverse field Diabrotica virgifera vigifera, Agriotes spp, Hypnoidus bicolor, Limonius canus, Delia crops radicum, Popillia japonica fruiting vegetables Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis, peanut Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis onion Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis oil seed rape Anthonomus grandis, Meligethes aeneus, Phyllotreta spp, Leptinotarsa decemlineata ornamentals Thrips tabaci, Scirtothrips dorsalis, Frankliniella occidentalis speciality crops (as defined in https: / / www.ams.usda.gov / ser vices / qrants / sc bqp / specialty-crop) Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Myzus persicae In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 5 and Table P ”) controls one or more of Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis), Helicoverpa armigera, Heliothis virescens, Leucinodes orbonalis, Tuta absoluta, Plutella xylostella, Cydia pomonella, Lobesia spp, Tortrixsp., Maruca vitrata, Chrysodeixis includens, Agrotis ipsilon, Elasmopalpus lignosellus, Dalbulus maidis, Phyllotreta spp, Popillia japonica, Scirpophaga incertulas, Chilo suppressalis, Cnaphalocrosis medinalis, Nilaparvata lugens, Sogatella frucifera, Laodelphax striatellus, Nephotettix spp, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, and Myzus persicae; such as Spodoptera spp (for example, Spodoptera frugiperda, Spodoptera littoralis) + TX, Helicoverpa armigera + TX, Heliothis virescens + TX, Leucinodes orbonalis + TX, Tuta absoluta + TX, Plutella xylostella + TX, Cydia pomonella + TX, Lobesia spp + TX, Tortrix spp + TX, Maruca vitrata + TX, Chrysodeixis includens + TX, Agrotis ipsilon + TX, Elasmopalpus lignosellus + TX, Dalbulus maidis + TX, Phyllotreta spp + TX, Popillia japonica + TX, Scirpophaga incertulas + TX, Chilo suppressalis + TX, Cnaphalocrosis medinalis + TX, Nilaparvata lugens + TX, Sogatella frucifera + TX, Laodelphax striatellus + TX, Nephotettix spp + TX, Bemisia tabaci + TX, Trialeurodes vaporariorum + TX, Aphis gossypii + TX, and Myzus persicae + TX. Compounds according to the invention may possess any number of benefits including, inter alia, advantageous levels of biological activity for protecting plants against insects or superior properties for use as agrochemical active ingredients (for example, greater biological activity, an advantageous spectrum of activity, an increased safety profile (against non-target organisms above and below ground (such as fish, birds and bees), improved physico-chemical properties, or increased biodegradability). In particular, it has been surprisingly found that certain compounds of formula (I) may show an advantageous safety profile with respect to non-target arthropods, in particular pollinators such as honey bees, solitary bees, and bumble bees. Most particularly, Apis mellifera. The compounds according to the invention can be used as pesticidal agents in unmodified form, but they are generally formulated into compositions in various ways using formulation adjuvants, such as carriers, solvents and surface-active substances. The formulations can be in various physical forms, e.g. in the form of dusting powders, gels, wettable powders, water-dispersible granules, water-dispersible tablets, effervescent pellets, emulsifiable concentrates, microemulsifiable concentrates, oil-in-water emulsions, oil- flowables, aqueous dispersions, oily dispersions, suspo-emulsions, capsule suspensions, emulsifiable granules, soluble liquids, water-soluble concentrates (with water or a water-miscible organic solvent as carrier), impregnated polymer films or in other forms known e.g. from the Manual on Development and Use of FAO and WHO Specifications for Pesticides, United Nations, First Edition, Second Revision (2010). Such formulations can either be used directly or diluted prior to use. The dilutions can be made, for example, with water, liquid fertilisers, micronutrients, biological organisms, oil or solvents. The formulations can be prepared e.g. by mixing the active ingredient with the formulation adjuvants in order to obtain compositions in the form of finely divided solids, granules, solutions, dispersions or emulsions. The active ingredients can also be formulated with other adjuvants, such as finely divided solids, mineral oils, oils of vegetable or animal origin, modified oils of vegetable or animal origin, organic solvents, water, surface-active substances or combinations thereof. The active ingredients can also be contained in very fine microcapsules. Microcapsules contain the active ingredients in a porous carrier. This enables the active ingredients to be released into the environment in controlled amounts (e.g. slow-release). Microcapsules usually have a diameter of from 0.1 to 500 microns. They contain active ingredients in an amount of about from 25 to 95 % by weight of the capsule weight. The active ingredients can be in the form of a monolithic solid, in the form of fine particles in solid or liquid dispersion or in the form of a suitable solution. The encapsulating membranes can comprise, for example, natural or synthetic rubbers, cellulose, styrene / butadiene copolymers, polyacrylonitrile, polyacrylate, polyesters, polyamides, polyureas, polyurethane or chemically modified polymers and starch xanthates or other polymers that are known to the person skilled in the art. Alternatively, very fine microcapsules can be formed in which the active ingredient is contained in the form of finely divided particles in a solid matrix of base substance, but the microcapsules are not themselves encapsulated. The formulation adjuvants that are suitable for the preparation of the compositions according to the invention are known perse. As liquid carriers there may be used: water, toluene, xylene, petroleum ether, vegetable oils, acetone, methyl ethyl ketone, cyclohexanone, acid anhydrides, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl esters of acetic acid, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol abietate, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, / V, / V-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, diproxitol, alkylpyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, alpha-pinene, d-limonene, ethyl lactate, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, gamma-butyrolactone, glycerol, glycerol acetate, glycerol diacetate, glycerol triacetate, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropylbenzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, methylene chloride, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate, oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylenesulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol, and alcohols of higher molecular weight, such as amyl alcohol, tetra hydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol, A / -methyl-2-pyrrolidone and the like. Suitable solid carriers are, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kieselguhr, limestone, calcium carbonate, bentonite, calcium montmorillonite, cottonseed husks, wheat flour, soybean flour, pumice, wood flour, ground walnut shells, lignin and similar substances. A large number of surface-active substances can advantageously be used in both solid and liquid formulations, especially in those formulations which can be diluted with a carrier prior to use. Surfaceactive substances may be anionic, cationic, non-ionic or polymeric and they can be used as emulsifiers, wetting agents or suspending agents or for other purposes. Typical surface-active substances include, for example, salts of alkyl sulfates, such as diethanolammonium lauryl sulfate; salts of alkylarylsulfonates, such as calcium dodecylbenzenesulfonate; alkylphenol / alkylene oxide addition products, such as nonylphenol ethoxylate; alcohol / alkylene oxide addition products, such as tridecylalcohol ethoxylate; soaps, such as sodium stearate; salts of alkylnaphthalenesulfonates, such as sodium dibutylnaphthalenesulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryltrimethylammonium chloride, polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono- and dialkylphosphate esters; and also further substances described e.g. in McCutcheon's Detergents and Emulsifiers Annual, MC Publishing Corp., Ridgewood New Jersey (1981). Further adjuvants that can be used in pesticidal formulations include crystallisation inhibitors, viscosity modifiers, suspending agents, dyes, anti-oxidants, foaming agents, light absorbers, mixing auxiliaries, antifoams, complexing agents, neutralising or pH-modifying substances and buffers, corrosion inhibitors, fragrances, wetting agents, take-up enhancers, micronutrients, plasticisers, glidants, lubricants, dispersants, thickeners, antifreezes, microbicides, and liquid and solid fertilisers. The compositions according to the invention can include an additive comprising an oil of vegetable or animal origin, a mineral oil, alkyl esters of such oils or mixtures of such oils and oil derivatives. The amount of oil additive in the composition according to the invention is generally from 0.01 to 10 %, based on the mixture to be applied. For example, the oil additive can be added to a spray tank in the desired concentration after a spray mixture has been prepared. Preferred oil additives comprise mineral oils or an oil of vegetable origin, for example rapeseed oil, olive oil or sunflower oil, emulsified vegetable oil, alkyl esters of oils of vegetable origin, for example the methyl derivatives, or an oil of animal origin, such as fish oil or beef tallow. Preferred oil additives comprise alkyl esters of C8-C22 fatty acids, especially the methyl derivatives of C12-C18 fatty acids, for example the methyl esters of lauric acid, palmitic acid and oleic acid (methyl laurate, methyl palmitate and methyl oleate, respectively). Many oil derivatives are known from the Compendium of Herbicide Adjuvants, 10th Edition, Southern Illinois University, 2010. The inventive compositions generally comprise from 0.1 to 99 % by weight, especially from 0.1 to 95 % by weight, of compounds of the present invention and from 1 to 99.9 % by weight of a formulation adjuvant which preferably includes from 0 to 25 % by weight of a surface-active substance. Whereas commercial products may preferably be formulated as concentrates, the end user will normally employ dilute formulations. The rates of application vary within wide limits and depend on the nature of the soil, the method of application, the crop plant, the pest to be controlled, the prevailing climatic conditions, and other factors governed by the method of application, the time of application and the target crop. As a general guideline compounds may be applied at a rate of from 1 to 2000 l / ha, especially from 10 to 1000 l / ha. Preferred formulations can have the following compositions (weight %): Emulsifiable concentrates: active ingredient: surface-active agent: liquid carrier: 1 to 95 %, preferably 60 to 90 % 1 to 30 %, preferably 5 to 20 % 1 to 80 %, preferably 1 to 35 % Dusts: active ingredient: solid carrier: 0.1 to 10 %, preferably 0.1 to 5 % 99.9 to 90 %, preferably 99.9 to 99 % Suspension concentrates: active ingredient: water: surface-active agent: 5 to 75 %, preferably 10 to 50 % 94 to 24 %, preferably 88 to 30 % 1 to 40 %, preferably 2 to 30 % Wettable powders: active ingredient: surface-active agent: solid carrier: 0.5 to 90 %, preferably 1 to 80 % 0.5 to 20 %, preferably 1 to 15 % 5 to 95 %, preferably 15 to 90 % Granules: active ingredient: solid carrier: 0.1 to 30 %, preferably 0.1 to 15 % 99.5 to 70 %, preferably 97 to 85 % The activity of the compositions according to the invention can be broadened considerably, and adapted to prevailing circumstances, by adding other insecticidally, acaricidally and / or fungicidally active ingredients. The mixtures of the compounds of formula (I) with other insecticidally, acaricidally and / or fungicidally active ingredients may also have further surprising advantages which can also be described, in a wider sense, as synergistic activity. For example, better tolerance by plants, reduced phytotoxicity, insects can be controlled in their different development stages or better behaviour during their production, for example during grinding or mixing, during their storage or during their use. Suitable additions to active ingredients here are, for example, representatives of the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, ureas, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridinylmethyleneamino derivatives, macrolides, neonicotinoids and Bacillus thuringiensis preparations. The following mixtures of a compound of formula (I) with an active substances are preferred (the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 5 and Table P”): an adjuvant selected from the group of substances consisting of petroleum oils (alternative name) (628) + TX; abamectin + TX, acequinocyl + TX, acetamiprid + TX, acetoprole + TX, acrinathrin + TX, acynonapyr + TX, afidopyropen + TX, afoxolaner + TX, alanycarb + TX, allethrin + TX, alpha-cypermethrin + TX, alphamethrin + TX, amidoflumet + TX, aminocarb + TX, azocyclotin + TX, bensultap + TX, benzoximate + TX, benzpyrimoxan + TX, betacyfluthrin + TX, beta-cypermethrin + TX, bifenazate + TX, bifenthrin + TX, binapacryl + TX, bioallethrin + TX, S-bioallethrin + TX, bioresmethrin + TX, bistrifluron + TX, broflanilide + TX, brofluthrinate + TX, bromophos-ethyl + TX, buprofezine + TX, butocarboxim + TX, cadusafos + TX, carbaryl + TX, carbosulfan + TX, cartap + TX, CAS number: 1632218-00-8 + TX, CAS number: 180811549-2 + TX, CAS number: 2032403-97-5 + TX, CAS number: 2044701-44-0 + TX, CAS number: 212870605-6 + TX, CAS number: 2095470-94-1 + TX, CAS number: 2377084-09-6 + TX, CAS number: 144568371-5 + TX, CAS number: 2408220-94-8 + TX, CAS number: 2408220-91-5 + TX, CAS number: 136507072-9 + TX, CAS number: 2171099-09-3 + TX, CAS number: 2396747-83-2 + TX, CAS number: 213304231-4 + TX, CAS number: 2133042-44-9 + TX, CAS number: 1445684-82-1 + TX, CAS number: 144568482-1 + TX, CAS number: 1922957-45-6 + TX, CAS number: 1922957-46-7 + TX, CAS number: 192295747-8 + TX, CAS number: 1922957-48-9 + TX, CAS number: 2415706-16-8 + TX, CAS number: 159462487-9 + TX, CAS number: 1594637-65-6 + TX, CAS number: 1594626-19-3 + TX, CAS number: 199045752-7 + TX, CAS number: 1990457-55-0 + TX, CAS number: 1990457-57-2 + TX, CAS number: 199045777-6 + TX, CAS number: 1990457-66-3 + TX, CAS number: 1990457-85-6 + TX, CAS number: 222013255-6 + TX, CAS number: 1255091-74-7 + TX, CAS number: 2719848-60-7 + TX, CAS number: 1956329 03-5 + TX, chlorantraniliprole + TX, chlordane + TX, chlorfenapyr + TX, chloroprallethrin + TX, chromafenozide + TX, clenpirin + TX, cloethocarb + TX, clothianidin + TX, 2-chlorophenyl N-methylcarbamate (CPMC) + TX, cyanofenphos + TX, cyantraniliprole + TX, cyclaniliprole + TX, cyclobutrifluram + TX, cycloprothrin + TX, cycloxaprid + TX, cyenopyrafen + TX, cyetpyrafen (or etpyrafen) + TX, cyflumetofen + TX, cyfluthrin + TX, cyhalodiamide + TX, cyhalothrin + TX, cypermethrin + TX, cyphenothrin + TX, cyproflanilide + TX, cyromazine + TX, deltamethrin + TX, diafenthiuron + TX, dialifos + TX, dibrom + TX, dicloromezotiaz + TX, diflovidazine + TX, diflubenzuron + TX, dimpropyridaz + TX, dinactin + TX, dinocap + TX, dinotefuran + TX, dioxabenzofos + TX, emamectin (oremamectin benzoate) + TX, empenthrin + TX, epsilon - momfluorothrin + TX, epsilon-metofluthrin + TX, esfenvalerate + TX, ethion + TX, ethiprole + TX, etofenprox + TX, etoxazole + TX, famphur + TX, fenazaquin + TX, fenfluthrin + TX,, fenmezoditiaz + TX, fenitrothion + TX, fenobucarb + TX, fenothiocarb + TX, fenoxycarb + TX, fenpropathrin + TX, fenpyroximate + TX, fensulfothion + TX, fenthion + TX, fentinacetate + TX, fenvalerate + TX, fipronil + TX, flometoquin + TX, flonicamid + TX, fluacrypyrim + TX, fluazaindolizine + TX, fluazuron + TX, flubendiamide + TX, flubenzimine + TX, fluchlordiniliprole + TX, flucitrinate + TX, flucycloxuron + TX, flucythrinate + TX, fluensulfone + TX, flufenerim + TX, flufenprox + TX, flufiprole + TX, fluhexafon + TX, flumethrin + TX, fluopyram + TX, flupentiofenox + TX, flupyradifurone + TX, flupyroxystrobin + TX, flupyrimin + TX, fluralaner + TX, fluvalinate + TX, fluxametamide + TX, fosthiazate + TX, gamma-cyhalothrin + TX, guadipyr + TX, halofenozide + TX, halfenprox + TX, heptafluthrin + TX, hexythiazox + TX, hydramethylnon + TX, imicyafos + TX, imidacloprid + TX, imiprothrin + TX, indazapyroxamet + TX, indoxacarb + TX, iodomethane + TX, iprodione + TX, isocycloseram + TX, isothioate + TX, ivermectin + TX, kappa-bifenthrin + TX, kappa-tefluthrin + TX, lambda-Cyhalothrin + TX, ledprona + TX, lepimectin + TX, lotilaner + TX, lufenuron + TX, metaflumizone + TX, metaldehyde + TX, metam + TX, methomyl + TX, methoxyfenozide + TX, metofluthrin + TX, metolcarb + TX, mexacarbate + TX, milbemectin + TX, momfluorothrin + TX, niclosamide + TX, nicofluprole + TX; nitenpyram + TX, nithiazine + TX, omethoate + TX, oxamyl + TX, oxazosulfyl + TX, parathion-ethyl + TX, permethrin + TX, phenothrin + TX, phosphocarb + TX, piperonylbutoxide + TX, pirimicarb + TX, pirimiphos-ethyl + TX, pirimiphos-methyl + TX, Polyhedrosis virus + TX, prallethrin + TX, profenofos + TX, profluthrin + TX, propargite + TX, propetamphos + TX, propoxur + TX, prothiophos + TX, protrifenbute + TX, pyflubumide + TX, pymetrozine + TX, pyraclofos + TX, pyrafluprole + TX, pyridaben + TX, pyridalyl + TX, pyrifluquinazon + TX, pyrimidifen + TX, pyriminostrobin + TX, pyriprole + TX, pyriproxyfen + TX, resmethrin + TX, sarolaner + TX, selamectin + TX, silafluofen + TX, spinetoram + TX, spinosad + TX, spirobudifen + TX; spirodiclofen + TX, spiromesifen + TX, spiropidion + TX, spirotetramat + TX, spidoxamat + TX, sulfoxaflor + TX, tebufenozide + TX, tebufenpyrad + TX, tebupirimiphos + TX, tefluthrin + TX, temephos + TX, tetrachlorantraniliprole + TX, tetradiphon + TX, tetramethrin + TX, tetramethylfluthrin + TX, tetranactin + TX, tetraniliprole + TX, theta-cypermethrin + TX, thiacloprid + TX, thiamethoxam + TX, thiocyclam + TX, thiodicarb + TX, thiofanox + TX, thiometon + TX, thiosultap + TX, tigolaner + TX, tiorantraniliprole + TX; tioxazafen + TX, tolfenpyrad + TX, toxaphene + TX, tralomethrin + TX, transfluthrin + TX, triazamate + TX, triazophos + TX, trichlorfon + TX, trichloronate + TX, trichlorphon + TX, trifluenfuronate + TX, triflumezopyrim + TX, tyclopyrazoflor + TX, zeta-cypermethrin + TX, Extract of seaweed and fermentation product derived from melasse + TX, Extract of seaweed and fermentation product derived from melasse comprising urea + TX, amino acids + TX, potassium and molybdenum and EDTA-chelated manganese + TX, Extract of seaweed and fermented plant products + TX, Extract of seaweed and fermented plant products comprising phytohormones + TX, vitamins + TX, EDTA-chelated copper + TX, zinc + TX, and iron + TX, azadirachtin + TX, Bacillus aizawai + TX, Bacillus chitinosporus AQ746 (NRRL Accession No B-21 618) + TX, Bacillus firmus + TX, Bacillus kurstaki + TX, Bacillus mycoides AQ726 (NRRL Accession No. B-21664) + TX, Bacillus pumilus (NRRL Accession No B-30087) + TX, Bacillus pumilus AQ717 (NRRL Accession No. B-21662) + TX, Bacillus sp. AQ178 (ATCC Accession No. 53522) + TX, Bacillus sp. AQ175 (ATCC Accession No. 55608) + TX, Bacillus sp. AQ177 (ATCC Accession No. 55609) + TX, Bacillus subtilis unspecified + TX, Bacillus subtilis AQ153 (ATCC Accession No. 55614) + TX, Bacillus subtilis AQ30002 (NRRL Accession No. B-50421) + TX, Bacillus subtilis AQ30004 (NRRL Accession No. B- 50455) + TX, Bacillus subtilis AQ713 (NRRL Accession No. B-21661) + TX, Bacillus subtilis AQ743 (NRRL Accession No. B-21665) + TX, Bacillus thuringiensis AQ52 (NRRL Accession No. B-21619) + TX, Bacillus thuringiensis BD#32 (NRRL Accession No B-21530) + TX, Bacillus thuringiensis subspec, kurstaki BMP 123 + TX, Beauveria bassiana + TX, D-limonene + TX, Granulovirus + TX, Harpin + TX, Helicoverpa armigera Nucleopolyhedrovirus + TX, Helicoverpa zea Nucleopolyhedrovirus + TX, Heliothis virescens Nucleopolyhedrovirus + TX, Heliothis punctigera Nucleopolyhedrovirus + TX, Metarhizium spp. +TX, Muscodoralbus 620 (NRRL Accession No. 30547) + TX, Muscodor roseus A3-5 (NRRL Accession No. 30548) + TX, Neem tree based products + TX, Paecilomyces fumosoroseus + TX, Paecilomyces lilacinus + TX, Pasteuria nishizawae + TX, Pasteuria penetrans + TX, Pasteuria ramosa + TX, Pasteuria thornei + TX, Pasteuria usgae + TX, P-cymene + TX, Plutella xylostella Granulosis virus + TX, Plutella xylostella Nucleopolyhedrovirus + TX, Polyhedrosis virus + TX, pyrethrum + TX, QRD 420 (a terpenoid blend) + TX, QRD 452 (a terpenoid blend) + TX, QRD 460 (a terpenoid blend) + TX, Quillaja saponaria + TX, Rhodococcus globerulus AQ719 (NRRL Accession No B-21663) + TX, Spodoptera frugiperda Nucleopolyhedrovirus + TX, Streptomyces galbus (NRRL Accession No. 30232) + TX, Streptomyces sp. (NRRL Accession No. B-30145) + TX, Terpenoid blend + TX, and Verticillium spp. + TX; an algicide selected from the group of substances consisting of bethoxazin [CCN] + TX, copper dioctanoate (IUPAC name) (170) + TX, copper sulfate (172) + TX, cybutryne [CCN] + TX, dichlone (1052) + TX, dichlorophen (232) + TX, endothal (295) + TX, fentin (347) + TX, hydrated lime [CCN] + TX, nabam (566) + TX, quinoclamine (714) + TX, quinonamid (1379) + TX, simazine (730) + TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347) + TX; an anthelmintic selected from the group of substances consisting of abamectin (1) + TX, crufomate (1011) + TX, cyclobutrifluram + TX, doramectin (alternative name) [CCN] + TX, emamectin (291) + TX, emamectin benzoate (291) + TX, eprinomectin (alternative name) [CCN] + TX, ivermectin (alternative name) [CCN] + TX, milbemycin oxime (alternative name) [CCN] + TX, moxidectin (alternative name) [CCN] + TX, piperazine [CCN] + TX, selamectin (alternative name) [CCN] + TX, spinosad (737) and thiophanate (1435) + TX; an avicide selected from the group of substances consisting of chloralose (127) + TX, endrin (1122) + TX, fenthion (346) + TX, pyridin-4-amine (IUPAC name) (23) and strychnine (745) + TX; a bactericide selected from the group of substances consisting of 1-hydroxy-1 / 7-pyridine-2-thione (IUPAC name) (1222) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, 8-hydroxyquinoline sulfate (446) + TX, bronopol (97) + TX, copper dioctanoate (IUPAC name) (170) + TX, copper hydroxide (IUPAC name) (169) + TX, cresol [CCN] + TX, dichlorophen (232) + TX, dipyrithione (1105) + TX, dodicin (1112) + TX, fenaminosulf (1144) + TX, formaldehyde (404) + TX, hydrargaphen (alternative name) [CCN] + TX, kasugamycin (483) + TX, kasugamycin hydrochloride hydrate (483) + TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308) + TX, nitrapyrin (580) + TX, octhilinone (590) + TX, oxolinic acid (606) + TX, oxytetracycline (611) + TX, potassium hydroxyquinoline sulfate (446) + TX, probenazole (658) + TX, streptomycin (744) + TX, streptomycin sesquisulfate (744) + TX, tecloftalam (766) + TX, and thiomersal (alternative name) [CCN] + TX; a biological agent selected from the group of substances consisting of Adoxophyes orana GV (alternative name) (12) + TX, Agrobacterium radiobacter (alternative name) (13) + TX, Amblyseius spp. (alternative name) (19) + TX, Anagrapha falcifera NPV (alternative name) (28) + TX, Anagrus atomus (alternative name) (29) + TX, Aphelinus abdominalis (alternative name) (33) + TX, Aphidius colemani (alternative name) (34) + TX, Aphidoletes aphidimyza (alternative name) (35) + TX, Autographa californica NPV (alternative name) (38) + TX, Bacillus firmus (alternative name) (48) + TX, Bacillus sphaericus Neide (scientific name) (49) + TX, Bacillus thuringiensis Berliner (scientific name) (51) + TX, Bacillus thuringiensis subsp. aizawai (scientific name) (51) + TX, Bacillus thuringiensis subsp. israelensis (scientific name) (51) + TX, Bacillus thuringiensis subsp. japonensis (scientific name) (51) + TX, Bacillus thuringiensis subsp. kurstaki (scientific name) (51) + TX, Bacillus thuringiensis subsp. tenebrionis (scientific name) (51) + TX, Beauveria bassiana (alternative name) (53) + TX, Beauveria brongniartii (alternative name) (54) + TX, Chrysoperla carnea (alternative name) (151) + TX, Cryptolaemus montrouzieri (alternative name) (178) + TX, Cydia pomonella GV (alternative name) (191) + TX, Dacnusa sibirica (alternative name) (212) + TX, Diglyphus isaea (alternative name) (254) + TX, Encarsia formosa (scientific name) (293) + TX, Eretmocerus eremicus (alternative name) (300) + TX, Helicoverpa zea NPV (alternative name) (431) + TX, Heterorhabditis bacteriophora and H. megidis (alternative name) (433) + TX, Hippodamia convergens (alternative name) (442) + TX, Leptomastix dactylopii (alternative name) (488) + TX, Macrolophus caliginosus (alternative name) (491) + TX, Mamestra brassicae NPV (alternative name) (494) + TX, Metaphycus helvolus (alternative name) (522) + TX, Metarhizium anisopliae var. acridum (scientific name) (523) + TX, Metarhizium anisopliae var. anisopliae (scientific name) (523) + TX, Neodiprion sertifer NPV and N. lecontei NPV (alternative name) (575) + TX, Orius spp. (alternative name) (596) + TX, Paecilomyces fumosoroseus (alternative name) (613) + TX, Phytoseiulus persimilis (alternative name) (644) + TX, Spodoptera exigua multicapsid nuclear polyhedrosis virus (scientific name) (741) + TX, Steinernema bibionis (alternative name) (742) + TX, Steinernema carpocapsae (alternative name) (742) + TX, Steinernema feltiae (alternative name) (742) + TX, Steinernema glaseri (alternative name) (742) + TX, Steinernema riobrave (alternative name) (742) + TX, Steinernema riobravis (alternative name) (742) + TX, Steinernema scapterisci (alternative name) (742) + TX, Steinernema spp. (alternative name) (742) + TX, Trichogramma spp. (alternative name) (826) + TX, Typhlodromus occidentalis (alternative name) (844) and Verticillium lecanii (alternative name) (848) + TX; a soil sterilant selected from the group of substances consisting of iodomethane (IUPAC name) (542) and methyl bromide (537) + TX; a chemosterilant selected from the group of substances consisting of apholate [CCN] + TX, bisazir (alternative name) [CCN] + TX, busulfan (alternative name) [CCN] + TX, diflubenzuron (250) + TX, dimatif (alternative name) [CCN] + TX, hemel [CCN] + TX, hempa [CCN] + TX, metepa [CCN] + TX, methiotepa [CCN] +...

Claims

1. A compound of the formula (I)wherein:5        A is O, or S;X is N, or CR8;Y is N or CR8;Z is N or CR8;with the provision that at least one of X, Y, Z is N;10         R1 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl-C1-C6-alkyl, C3-C6-halocycloalkyl-C1-C6-alkyl, cyano-C1-C6-alkyl, cyano-C3-C6-cycloalkyl, cyano-C3-C6-cycloalkyl-C1-C6-alkyl, cyano-heterocycloalkyl, hydroxy-C3-C6-cycloalkyl, C1-C6-alkyl-carbonyloxy-C3-C6-cycloalkyl,  C1-C6-alkylsulfonyloxy-C3-C6-cycloalkyl,  C1-C6-alkoxy-C3-C6-15        cycloalkyl, C1-C6-haloalkoxy-C3-C6-cycloalkyl, C1-C6-alkylthio-C3-C6-cycloalkyl, C1-C6-haloalkylthio-C3-C6-cycloalkyl,  C1-C6-alkylsulfinyl-C3-C6-cycloalkyl,  C1-C6-haloalkylsulfinyl-C3-C6-cycloalkyl,  C1-C6-alkylsulfonyl-C3-C6-cycloalkyl,      C1-C6-haloalkylsulfonyl-C3-C6-cycloalkyl,      C2-C6-alkynyl-C3-C6-cycloalkyl,   C1-C6-alkoxycarbonyl-C3-C6-cycloalkyl,   carboxy-C3-C6-cycloalkyl,   carbamoyl-C3-C6-cycloalkyl, C1-C6-alkylaminocarbonyl-C3-C6-cycloalkyl (which may be mono- or poly-substituted by R8),20        C4-C8-bicycloalkyl, C1-C6-alkoxyimino, phenyl (which may be mono- or poly-substituted by R10), phenyl-C1-C6-alkyl (the phenyl may be mono- or poly-substituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-C1-C3-alkyl (the heteroaryl may be mono- or polysubstituted by R10), heteroaryl-C3-C6-cycloalkyl (the heteroaryl may be mono- or poly-substituted by R10), heterocycloalkyl (which may be substituted by R8), heterocycloalkyl-C1-C6-alkyl (which may be25        substituted by R8), or heterocycloalkyl-C3-C6-cycloalkyl (the heterocycloalkyl may be substituted byR8);R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-haloalkoxy, C3-C6-cycloalkyl-C1-C6-alkyl, C3-C6-halocycloalkyl-C1-C6-alkyl, phenyl (which30        may be mono- or poly-substituted by R10), phenyl-C1-C6-alkyl (the phenyl may be mono- or polysubstituted by R10), heteroaryl (the heteroaryl may be mono- or poly-substituted by R10), heteroaryl-C1-C3-alkyl (the heteroaryl may be mono-substituted or polysubstituted by R10), cyano, cyano-C1-C6-alkyl, cyano-C3-C6-cycloalkyl,   hydroxy, formyl, C1-C6-alkylcarbonyl,   C1-C6-alkoxycarbonyl,   C3-C6-2023268590   11 Sep 2026cycloalkylcarbonyl, benzoyl that is mono or polysubstituted by R10, C1-C6-haloalkoxycarbonyl, C2-C6-alkenyloxycarbonyl, carbamoyl, C1-C6-alkylaminocarbonyl (the amino group may be substituted by R8), C1-C6-alkoxycarbonyl C1-C6-alkylamino (the amino group may be substituted by R8), C1-C6-alkoxycarbonyl amino (the amino group may be substituted by R8), (C1-C6-alkylthio)carbonyl, (C1-C6-alkyl)thiocarbonyl, (C1-C6-alkoxy)thiocarbonyl, thiocarbamoyl, C1-C6-alkylamino-thiocarbonyl (the amino group may be substituted by R8), C1-C6-alkylsulfonyl, C1-C6-haloalkylsulphonyl, sulfamoyl, C1-C6-alkylaminosulfonyl (the amino group may be substituted by R8), C1-C6-alkoxycarbonyl-C1-C6-alkyl, aminocarbonyl-C1-C6-alkyl, C1-C6-alkylaminocarbonyl-C1-C6-alkyl (the amino group may be substituted by R8), C3-C6-cycloalkylaminocarbonyl-C1-C6-alkyl (the amino group may be substituted by R8), C1-C6-haloalkylaminocarbonyl-C1-C6-alkyl (the amino group may be substituted by R8), C1-C6-alkylcarbonyl-C1-C6-alkyl,    C1-C6-haloalkylcarbonyl-C1-C6-alkyl,    C1-C6-alkylcarbonyloxy-C1-C6-alkyl,    C1-C6-alkoxycarbonyloxy-C1-C6-alkyl, C1-C6-alkoxycarbonylamino-C1-C6-alkyl (the amino group may be substituted by R8), hydroxyimino, hydroxyamino-C1-C6-alkyl, C1-C6-alkoxyimino, C1-C6-alkoxyimino-C1-C6-alkyl, or C1-C6-haloalkoxyimino-C1-C6-alkyl;15         R3 is halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C1-C6-haloalkyl, or C1-C6-haloalkoxy;R4 is, or                      ; orR5 is C1-C3-alkylsulfonylamino, C1-C3-haloalkylsulfonylamino, or C3-C6-cycloalkylsulfonylamino, wherein any of said amino-groups is unsubstituted or substituted by R6; and wherein any of said cycloalkyl-groups may be mono-or polysubstituted by R9;20         R6 is C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, cyano-C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, C1-C6-alkylcarbonyl, or C1-C6-alkoxycarbonyl;R8 is hydrogen, halogen, C1-C3-alkyl, C1-C3-alkoxy, C1-C3-haloalkyl, or cyano;R9 is halogen, C1-C3-alkyl, C1-C3-alkoxy, C1-C3-haloalkyl, or cyano; andR10 is halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C3-C6-cycloalkyl-25        C1-C6-alkyl, C3-C6-halocycloalkyl-C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulphonyl, C1-C6-alkylthio-C1-C6-alkyl,     C1-C6-haloalkylthio-C1-C6-alkyl,     C1-C6-alkylsulfonyloxy,     C1-C6-haloalkylsulfonyloxy, phenyl (which may be mono- or poly-substituted independently selected from halogen, C1-C6-alkyl and C1-C6-haloalkyl), phenyl-C1-C6-alkyl, phenyl-C1-C6-alkoxy, cyano, and nitro;30       or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer and N-oxide of thecompound of formula (I).

2. The compound according to claim 1, wherein the compound of formula (I) is represented by the formula (I-1), (I-2), (I-3), or (I-4), where A, R1, R2, R3 and R4 are as defined in claim 1.2023268590   11 Sep 202610(I-1)(I-3)(I-2)(I-4)3. The compound according to claim 1, wherein the compound of formula (I) is represented by the formula (I-1a), (I-2a), (I-3a), or (I-4a), where R1, R2, R3 and R6 are as defined in claim 1; and wherein R7 is, independent of (I-1a), (I-2a), (I-3a), and (I-4a), selected from C1-C3-alkyl, C1-C3-haloalkyl, or C3-C6-cycloalkyl, wherein said cycloalkyl-group may be mono or polysubstituted by R9, wherein R9 is as defined in claim 1.

4. The compounds according to claim 3 wherein the compound of formula (I) represented by the formula (I-1a), (I-2a), (I-3a), or (I-4a), is an (S) enantiomer.15    5. The compound according to any one of claims 1 to 4, wherein R1 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkynyl, C3-C6-cycloalkyl, cyano-C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, heterocyclyl, or C1-C6-alkoxy-C3-C6-cycloalkyl; and R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, C1-C6-alkoxy-C3-C6-cycloalkyl, C1-C6-alkoxy-C1-C6-alkyl, or C1-C6-alkylcarbonyl.

206. The compound according to any one of claims 1 to 5, wherein R1 is C1-C3-alkyl, C1-C3-haloalkyl, C2-C4-alkynyl,   C3-C4-cycloalkyl,   C3-C4-halocycloalkyl,   C3-C4-cycloalkyl-C1-C3-alkyl,   4-membered2023268590   11 Sep 2026heterocyclyl having a SO2, or cyano-C3-C4-cycloalkyl; and R2 is hydrogen, C1-C3-alkyl, C1-C3-alkylcarbonyl, or C1-C3-alkoxycarbonyl.

7. The compound according to any one of claims 1 to 6, wherein R3 is halogen, C1-C6-alkyl, or cyano.

58. The compound according to claim 7, wherein R3 is chlorine, bromine or methyl.

9. The compound according to any one of claims 1 to 8, wherein R5 is isopropylsulfonylamino, difluoromethylsulfonylamino,    trifluoromethylsulfonylamino,    difluoromethylsulfonylamino,    or0        cyclopropylsulfonylamino.

10. The compound according to any one of claims 1 to 8, wherein R6 is hydrogen, C1-C3-alkyl, C1-C3-alkoxy-C1-C3-alkyl, C3-C4-cycloalkyl-C1-C3-alkyl, or C1-C3-alkylcarbonyl.15    11. The compound according to claim 1, selected from the group consisting of2-chloro-N-cyclopropyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2-chloro-N-(2,2,2-trifluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-20       carboxamide,2-chloro-N-cyclopropyl-5-[(2S)-2-(dichloromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(1-bicyclo[1.1.1]pentanyl)- 2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,tert-butyl N-[(1S)-2-[[6-chloro-5-[(1-cyanocyclopropyl)carbamoyl] -3-pyridyl]oxy]-1-methyl-ethyl]-N-25        (trifluoromethylsulfonyl)carbamate,2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2- [methyl(trifluoromethylsulfonyl) amino] propoxy]pyridine-3-carboxamide,2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-[cyanomethyl(trifluoromethylsulfonyl) amino] propoxy]pyridine-3-carboxamide,30       2-chloro-N-cyclopropyl-5-[(2S)-2- (difluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-tert-butyl-2-chloro-5-[(2S)-2- (trifluoromethylsulfonylamino) propoxy]pyridine-3-carboxamide, N-acetyl-2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy]pyridine-3-carboxamide,methyl N-[(1S)-2-[[6-chloro-5- (cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-N-35        (trifluoromethylsulfonyl)carbamate,2023268590   11 Sep 20262-chloro-5-[(2S)-2-[cyanomethyl (trifluoromethylsulfonyl)amino] propoxy]-N-cyclopropyl-pyridine-3-carboxamide,2-chloro-N-cyclopropyl-5-[(2S)-2-[methyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-3-carboxamide,5        2-chloro-N-cyclopropyl-5-[2- (trifluoromethylsulfonylamino) ethoxy] pyridine-3-carboxamide,2-chloro-N-(5-cyano-3-fluoro-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2-chloro-N-(5-chloro-3-fluoro-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,0        2-chloro-N-(5-chloro-3-methyl-2-pyridyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy]-N-(2,4,6-trifluorophenyl) pyridine-3-carboxamide,2-chloro-N-(4-cyano-2-fluoro-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-15       carboxamide,2-chloro-N-(2,4-difluorophenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2-chloro-N-(2-fluoro-4-methylsulfonyl-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,20        2-chloro-N-(4-chloro-2-fluoro-phenyl) -5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-(1-bicyclo[1.1.1]pentanyl)-2- methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-[(5-chloro-2-pyridyl)methyl]- 2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-25       carboxamide,N-(1-cyclopropylethyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-[(3-chloro-2-pyridyl)methyl]- 2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,30        N-(2,4-difluorophenyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-isopropyl-2-methyl-5-[(2S)-2- (trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-ethyl-2-methyl-5-[(2S)-2- (trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, N-(3,3-difluorocyclobutyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-35       carboxamide,2-methyl-N-[1-(5-methyl-1,2,4- oxadiazol-3-yl)ethyl]-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,N-(2,2-difluoroethyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2023268590   11 Sep 20261520253035N-cyclopropyl-N,2-dimethyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,tert-butyl N-[(1S)-2-[[6-chloro- 5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-N-(trifluoromethylsulfonyl)carbamate,5-[(2S)-2-[acetyl(trifluoromethylsulfonyl)amino] propoxy]-2-chloro-N-cyclopropyl- pyridine-3-carboxamide,N-benzyl-2-chloro-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyclopropylethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,2-chloro-N-[(1-cyanocyclopropyl) methyl]-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-(1-cyanocyclopropyl) -N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-(1-cyanocyclobutyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-ethyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(3-methyltetrahydrofuran-3-yl) -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3- carboxamide,2-chloro-N-prop-2-ynyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-[2-(cyclopropylmethylamino) -2-oxo-ethyl]-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(2,2-difluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-phenyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-N-(1-cyano-1-methyl-ethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-cyclopropyl-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-(2,2-difluoroethyl)-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-(4-fluoro-2-methyl-phenyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,N-cyclopropyl-5-[(2S)-2-[methoxymethyl (trifluoromethylsulfonyl) amino] propoxy]-2-methyl-pyridine-3-carboxamide,N-cyclopropyl-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide, 2-chloro-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy]-N-(2,2,2-trifluoroethyl)pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethyl sulfonyl)amino] propoxy] pyridine-3-carboxamide,2023268590   11 Sep 2026N-(1-bicyclo[1.1.1]pentanyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, N-(1-cyanocyclopropyl)-N,5-dimethyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,5        N-(4-ethylthiazol-5-yl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,N-(1-cyclopropylethyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,N-[1-(2-ethylthiazol-4-yl)ethyl]-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-0       carboxamide,N-(3-cyano-2-fluoro-phenyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide, 5-methyl-N-[1-(3-pyridyl)ethyl]-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,15        N-benzyl-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,N-(1-cyanocyclopropyl)-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl) amino] propoxy]-5-methyl-pyridine-4-carboxamide, 5-methyl-N-(2,2,2-trifluoroethyl)-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,20       5-bromo-N-cyclopropyl-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-4-carboxamide,5-bromo-N-(1-cyanocyclopropyl)-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino] propoxy] pyridine-4-carboxamide,5-bromo-N-cyclopropyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,25        5-bromo-N-(2,2,2-trifluoroethyl)-2-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-4-carboxamide,5-bromo-N-(1-cyanocyclopropyl)-2-[(2S)-2-(trifluoromethylsulfonyl amino) propoxy]pyridine-4-carboxamide,5-chloro-N-cyclopropyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,30       3-chloro-N-cyclopropyl-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridazine-4-carboxamide,3-chloro-N-(1-cyanocyclopropyl)-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridazine-4-carboxamide, andN-(1-bicyclo[1.1.1]pentanyl)-3-chloro-6-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]   pyridazine-4-carboxamide.

12. The compound according to claim 1, selected from the group consisting of2-chloro-N-cyclopropyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide,2023268590   11 Sep 20262-chloro-N-(2,2,2-trifluoroethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-(dichloromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl)-5-[(2S)-2-5       [cyanomethyl(trifluoromethylsulfonyl)amino]propoxy]pyridine-3-carboxamide,N-acetyl-2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino]propoxy]pyridine-3-carboxamide, methyl N-[(1S)-2-[[6-chloro-5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-N-(trifluoromethylsulfonyl)carbamate,0       2-chloro-5-[(2S)-2-[cyanomethyl(trifluoromethylsulfonyl)amino]propoxy]-N-cyclopropyl-pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-[methyl(trifluoromethylsulfonyl)amino]propoxy]pyridine-3-carboxamide, 2-chloro-N-(2,4-difluorophenyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-15      carboxamide,N-(1-bicyclo[1.1.1]pentanyl)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, tert-butyl N-[(1S)-2-[[6-chloro-5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-N-(trifluoromethylsulfonyl)carbamate,20       5-[(2S)-2-[acetyl(trifluoromethylsulfonyl)amino]propoxy]-2-chloro-N-cyclopropyl-pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclopropyl)-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-(1-cyanocyclobutyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-25      carboxamide,2-chloro-N-(1-cyano-1-methyl-ethyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-N-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide,30       2-chloro-N-(4-fluoro-2-methyl-phenyl)-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide, 2-chloro-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino]propoxy]-N-(2,2,2-trifluoroethyl)pyridine-3-carboxamide, 2-chloro-N-cyclopropyl-5-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl)amino]propoxy]pyridine-3-35      carboxamide, and5-bromo-N-cyclopropyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-4-carboxamide.

13. A compound selected from the group consisting of2023268590   11 Sep 2026[(1S)-2-[[6-chloro-5- [(1-cyanocyclopropyl)carbamoyl]-3-pyridyl]oxy]-1-methyl-ethyl]-(trifluoromethylsulfonyl)amino]methyl 2-methylpropanoate,[[(1S)-2-[[6-chloro-5-(cyclopropylcarbamoyl)-3-pyridyl]oxy]-1-methyl-ethyl]-(trifluoromethylsulfonyl) amino] methyl 2-methylpropanoate,5         N-[1-[2-(5-cyano-2-pyridyl)-1,2,4-triazol-3-yl] ethyl]-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,N-[(2E)-2-methoxyimino-1,1-dimethyl-ethyl] -2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-methyl-N-[3-oxo-2-(2,2,2-trifluoroethyl) isoxazolidin-4-yl]-5-[(2S)-2-(trifluoromethylsulfonylamino)0        propoxy] pyridine-3-carboxamide,N-[1-(4-fluorophenyl)-2-oxo-pyrrolidin-3-yl] -2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,N-(cyclopropylmethoxy)-2-methyl-5-[(2S)-2-(trifluoromethylsulfonylamino) propoxy] pyridine-3-carboxamide,15        2-chloro-N-[(4S)-2-ethyl-3-oxo-isoxazolidin-4-yl] -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-3-carboxamide,2-chloro-N-[3-oxo-2-(2,2,2-trifluoroethyl) isoxazolidin-4-yl]-5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-3-carboxamide,2-chloro-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl] -5-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]20        pyridine-3-carboxamide,N-(1,3-dihydroisobenzofuran-5-yl methyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-4-carboxamide,5-methyl-N-[2-oxo-1-(2,2,2-trifluoroethyl) pyrrolidin-3-yl]-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,25        N-[2-(2-fluorophenoxy)ethyl]-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy] pyridine-4-carboxamide,N-(5-methoxy-1,1-dimethyl-pent-2-ynyl)-5-methyl-2-[(2S)-2-(trifluoromethylsulfonylamino)propoxy]pyridine-4-carboxamide,N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-[(2S)-2-[methoxymethyl(trifluoromethylsulfonyl) amino]30        propoxy]-5-methyl-pyridine-4-carboxamide, and5-bromo-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-[(2S)-2-(trifluoromethylsulfonylamino)    propoxy]pyridine-4-carboxamide.

14. A process for preparing a compound of formula (I) (wherein A is O) comprising transformation of a35        compound of formula (II), wherein R3, R4, X, Y, Z are as defined in any one of claims 1 to 10, with acompound of formula (III), wherein R1 and R2 are as defined in any one of claims 1, 5 or 6, via an intermediate acid chloride or activated acylating agent of formula (IV):2023268590   11 Sep 2026(IV)H(III)(I)G = halogen,G1                      G2G41015. A composition comprising a compound as defined in any one of claims 1 to 13, one or more auxiliaries and diluent, and optionally one or more other active ingredient.

16. A method of combating and controlling insects, or acarines which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, or acaricidally effective amount of a compound of formula I as defined in any one of claims 1 to 13 or a composition as defined in claim 15.

17. A method for the protection of plant propagation material from the attack by insects, or acarines, which comprises treating the propagation material or the site, where the propagation material is planted, with an effective amount of a compound of formula I as defined in any one of claims 1 to 13 or a composition as defined in claim 15.1518. A plant propagation material, such as a seed, comprising, or adhered thereto, a compound of formula I as defined in any one of claims 1 to 13.