Novel compounds as gcn2 inhibitors, pharmaceutical compositions and uses thereof

Abstract

Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein can typically inhibit an activity of a GCN2 and thus can be used for treating or preventing diseases related thereto.

Description

FIELD OF THE INVENTION The present invention relates to a novel compound as GCN2 inhibitor, a pharmaceutical composition including the same, and a pharmaceutical use thereof, which inhibits an activity of a GCN2 and thus maybe used valuably in preventing or treating diseases related thereto. BACKGROUND OF THE INVENTION Although diverse agents currently exist as therapeutic tools for cancer, it is widely accepted that more options still need to be invented to address unmet needs in the treatment of patients with cancer. Several studies have showed that modulating essential components in the tumor microenvironment could be a promising therapeutic option for cancer therapy. Cancer cells are generally in the tumor microenvironment with deprivations of several nutrients, e.g. glucose, oxygen and amino acids. The integrated stress response (ISR) is one pathway by which tumor cells adapt to nutrient deficiencies. General control nonderepressible kinase 2 (GCN2) (encoded by EIF2AK4 in humans) is one of the cytoplasmic serine / threonine protein kinase that mediates nutrient stress pathway in the tumor microenvironment. In response to amino acid deficiency, GCN2 phosphorylates the eukaryotic initiation factor 2 alpha (eIF2a) to activate the ISR, which leads to initiation of a transcriptional program through the activating transcription factor-4 (ATF4). ATF4 functions as a crucial ISR transcription factor promoting stress remediation by inducing expression of significant subset of genes related to amino acid import and metabolism. Under the ATF4-mediated ISR pathway, GCN2 plays as a pivotal component in response to recovery from nutrient deprivation. Also, in various human tumors, elevated expression level of GCN2 has been observed compared to normal tissues. GCN2 was highly expressed in various cancers (e.g. thyroid cancer, melanoma, testis cancer, endometrial cancer, lung cancer, head and neck cancer, pancreatic cancer, glioma, stomach cancer, urothelial cancer, skin cancer, breast cancer, colorectal cancer or renal cancer, etc.) at both protein and mRNA levels. In addition, GCN2 function is closely related to induction of T cell anergy under tryptophan depletion condition caused by indoleamine 2,3-dioxygenase (IDO). Inhibition of GCN2 has been reported as a therapeutic approach for cancer therapy (see, e.g., Wei, C. et al. in Mol. Biol. Cell. 2015, 26(6), 1044). Thus, inhibition of GCN2 activity may provide a beneficial therapeutic option for cancer patients. Furthermore, several GCN2 inhibitors resulting in the downregulation of eIF2a phosphorylation and ATF expression show the potential to treat neurodegenerative disease such as Alzheimer’s disease, Parkinson's Disease, Huntington’s Disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia as well as doxorubicin-induced cardiotoxicity (Nakagawa, T. et al. Int. J. Mol. Sci. 2019, 20, 2761). Recent studies have shown that GCN2 inhibitors might be potential drug for inflammation disease (Wang, P. et al. in J. Allergy Clin. Immunol. 2019, 144, p. 1091) and hepatic steatosis (Yuan, J. et al. in Redox Biology 2022, 49, 102224). SUMMARY OF THE INVENTION An objective of the present invention is to provide a novel compound showing general control nonderepressible kinase 2 (GCN2) inhibitory activity, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. An objective of the present invention is to provide a method for preparing the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof. An objective of the present invention is to provide a pharmaceutical composition for treating or preventing GCN2 activation-related diseases, comprising the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof as an active ingredient. An objective of the present invention is to provide a method for preventing or treating GCN2 activation-related diseases, including administering a therapeutically effective amount of the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof into a subject. An objective of the present invention is to provide a use of the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof in preparation of a medicament for preventing or treating GCN2 activation-related diseases. A objective of the present invention is to provide a use of the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof for preventing or treating GCN2 activation-related diseases. An objective of the present invention is to provide a method for inhibiting GCN2 activity, including administering a therapeutically effective amount of the compound of the present invention, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof into a subject. DETAILED DESCRIPTION OF THE INVENTION GCN2 INHIBITOR COMPOUND The present invention provides a compound represented by a following formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof: [Formula (I)] wherein, L1 and L2 each independently represent H; (Ci-5)alkyl optionally substituted with 4- to 6-membered heterocycloalkyl; or L1 and L2 are connected to form a 5- to 6membered ring, M represents H; halogen; (Ci-5)alkyl; (C3-7)cycloalkyl; or (Ci-5)alkoxy, G represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; or -NH2, wherein at least one H of -NH2 is optionally substituted with (Ci-5)alkyl, Y1 represents H; or (Ci-5)alkyl, Z represents -C(=O)-; or -CH2- optionally substituted with one or more (Ci-5)alkyl; or Z is connected to Y1 to form a 5- to 6-membered ring, Y3 represents 4- to 6-membered heterocycloalkyl in which at least one H is optionally and each independently substituted with W1 or W2; or Y3 is connected to Z to form an aryl or a heteroaryl in case that Z is connected to Y1 to form the 5- to 6membered ring, at least one H of the aryl and heteroaryl formed by Y3 and Z is optionally and independently substituted with W3, Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH, -NH2 or -CN; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; a heteroaryl optionally substituted with (Ci-s)alkyl; -COR1; -OR2; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with a heteroaryl, R1 represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (C3-7)cycloalkyl, R2 represents (Ci-5)alkyl optionally substituted with a heteroaryl; an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally and each independently substituted with one or more R2a, one or more R2a each independently represents halogen; (Ci-5)alkyl optionally substituted with an aryl, or 5- to 7- membered heterocycloalkyl substituted with (Ci-5)alkyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7- membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -OH; -CF3; (Ci-5)alkoxy optionally substituted with an aryl; an aryl in which at least one H of the aryl is optionally and each independently substituted with halogen; a heteroaryl optionally substituted with (Ci-5)alkyl; thio(Ci-5)alkyl; -CORla; or NR3R4, Rla is represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (C3-7)cycloalkyl, R3 and R4 each independently represent H; halogen; (Ci-5)alkyl optionally substituted with halogen, -CF3, -OH, (Ci-5)alkoxy, -N-[(Ci-5)alkyl][(Ci-5)alkyl], an aryl or (C3-7)cycloalkyl; (C3-7)cycloalkyl; (Ci-5)alkoxy; an aryl; or -C(=O)(Ci-5)alkyl, and one or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally substituted with one or more R10, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12, R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13, R8 represents H; or (Ci-5)alkyl, R9 represents an aryl optionally substituted with -NH2, one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH, R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen, R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2, Ru represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH. According to another specific embodiment of the present invention, it may be provided that Y3 represents azetidinyl; pyrrolidinyl; piperidinyl; tetrahydropyridinyl; or oxopyrrolidinyl, which is optionally substituted with W1 and W2, Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH or -CN; methylpiperazinyl; morpholinyl; pyridinyl; methylpyrazolyl; -COR1; -OR2; -NH2; -NH(pyridinyl) or -NH(pyrimidinyl), R1 represents (Ci-5)alkoxy; -OH; -NH2; -NH-(C3-7)cycloalkyl; oxopiperazinyl; morpholinyl; thiomorpholinyl; methylpiperazinyl; or tetrahydropyridinyl, R2 represents (Ci-5)alkyl optionally substituted with pyridinyl; halophenyl; dihalophenyl; (amino)halophenyl; (methylpiperazinyl)(methyl)phenyl; (dimehtylamino)phenyl; aminophenyl; diethylamino phenyl; biphenyl; (phenylpropanyl)phenyl;                           (cyclopropylamino)pyrimidinyl; (trifluoroethylamino)pyrimidinyl;         pyridinyl;                   pyrimidinyl; (cyclopropyl)(isoxazole)carboxamide; (dimethyl)pyrimidinyl; pyrazinyl; aminopyridinyl; halopyridinyl; aminopyrazinyl; halopyrimidinyl; (methyl)halopyrimidinyl; (amino)(methyl)pyrimidinyl; (amino)halopyrimidinyl; dihalopyrimidinyl;                               amino(dihalophenyl)pyrimidinyl; (amino)(trifluoromethyl)pyrimidinyl; pentylpyrimidinyl; methylpyrazolyl; methyl(benzothiophene)carboxylate;                methyl(thiophene)carboxylate; (thiophene)carboxylic               acid;                (thiophene)carboxamide; methyl(thiophene)carboxamide;              cyclopropyl(thiophene)carboxamide; methylisoxazolyl; benzoisoxazolyl; isothiazolyl; methylthiophenyl; pyrazolyl; (methyl)(trifluoromethyl)pyrazolyl; isoxazolyl; aminopyrazolyl; methyl(pyrrole)carboxylate; ethyl(isoxazole)carboxylate; (isoxazole)carboxamide; methyl(isoxazole)carboxamide; cyclopropyl(oxazole)carboxamide; (pyrimidine)carboxamide; dimethyl(pyrimidine)carboxamide; dimethyl(isoxazole)carboxamide: (pyrimidine)carboxylic           acid: methyl(pyrimidine)carboxamide: (pyrazine)carboxamide: methyl(pyrazine)carboxamide; aminotriazinyl; (methylamino)triazinyl; (dimethylamino)triazinyl; (cyclopropylamino)triazinyl; diaminotriazinyl; (amino) (pyrrolidinyl)triazinyl; aminopyrimidinyl; (methylamino)pyrimidinyl; (ethylamino)pyrimidinyl; (propylamino)pyrimidinyl; (butylamino)pyrimidinyl; (hydroxyethylamino)pyrimidinyl;               (hydroxypropylamino)pyrimidinyl; (methoxyethylamino)pyrimidinyl; (((dimethylamino)propyl)amino)pyrimidinyl; (benzylamino)pyrimidinyl;                         (phenethylamino)pyrimidinyl; (cyclohexylamino)pyrimidinyl;                        (dimethylamino)pyrimidinyl; (ethylmethylamino)pyrimidinyl;                        (diethylamino)pyrimidinyl; (ethylpropylamino)pyrimidinyl;                      (butylethylamino)pyrimidinyl; pyrrolidinylpyrimidinyl; (hydroxypyrrolidinyl)pyrimidinyl; piperidinylpyrimidinyl; (hydroxypiperidinyl)pyrimidinyl;                          morpholinopyrimidinyl; (methylpiperazinyl)pyrimidinyl;                (amino) (methylamino)pyrimidinyl; (amino)(pyrrolidinyl)pyrimidinyl;                  (methylamino)halopyrimidinyl; (ethylamino)halopyrimidinyl;                  (cyclopropylamino)halopyrimidinyl; (cyclohexylamino)halopyrimidinyl;               (dimethylamino)halopyrimidinyl; (ethylmethylamino)halopyrimidinyl;                (diethylamino)halopyrimidinyl; (methylphenylamino)halopyrimidinyl; (benzylmethylamino)halopyrimidinyl; (pyrrolidinyl)halopyrimidinyl;                         (piperidinyl)halopyrimidinyl; (morpholino)halopyrimidinyl;                   (thiomorpholino)halopyrimidinyl; (methylpiperazinyl)halopyrimidinyl;         (cyclopropylamino)methylpyrimidinyl; (amino)pyrimidinyl; (methylthio)pyrimidinyl; (methoxy)pyrimidinyl; (benzyloxy)pyrimidinyl; (difluoroethylamino)pyrimidinyl; (fluoroethylamino)pyrimidinyl; (cyclopentylamino)pyrimidinyl; butylamino)pyrimidinyl; acetamidopyrimidinyl; (difluoropropylamino)pyrimidinyl: (trifluoropropylamino)pyrimidinyl: (cyclobutylamino)pyrimidinyl: (isopropylamino)pyrimidinyl;         (sec- ((cyclopropylmethyl)amino)pyrimidinyl: (((dimethylamino)ethyl)amino)pyrimidinyl; (((dimethylamino)propyl)amino)pyrimidinyl;         (methoxyamino)pyrimidinyl; (benzylmethylamino)pyrimidinyl;               (cyclohexylamino)halopyrimidinyl; (cyclopropylmethylamino)halopyrimidinyl;         (benzylamino)halopyrimidinyl; (cyclopropylamino)halopyrimidinyl;         (cyclopropylamino)methylpyrimidinyl; (cyclopropylamino)(trifluoromethyl)pyrimidinyl; (cyclopropylamino)(methoxy)pyrimidinyl;            (cyclopropylamino)pyrazinyl; (ethylamino)pyrazinyl; (propylamino)pyrazinyl; (hydroxyethylamino)pyrazinyl; (((dimethylamino)ethyl)amino)pyrazinyl;                       phenylpyrimidinyl; (methylpyrazolyl)pyrimidinyl;                  (dimethylcyclohexenyl)pyrimidinyl; dihydropyranylpyrimidinyl; or pyridinylpyrimidinyl. According to another specific embodiment of the present invention, it may be provided that the compound represented by formula (I) above is a compound represented by a following formula (lb): [Formula (lb)] In Formula (lb), X represents -CH2-; or -C(=O)-, V1, V2, V3 and V4 each independently represent CH or N, wherein one or more H of V1, V2, V3 and V4 is optionally and each independently substituted with W3 in case that all of V1, V2, V3 and V4 are not N, one or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci- 5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein the aryl or the heteroaryl is optionally substituted with one or more R10, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12, R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13, R8 represents H; or (Ci-5)alkyl, R9 represents an aryl optionally substituted with -NH2, one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH, R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen, R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 optionally substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2, Ru represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH, L1, L2, M, and G are as defined in Formula (I). According to another specific embodiment of the present invention, it may be provided that: W3 independently represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; morpholinyl; tetrahydropyridinyl; dihydropyranyl;            / er / -butyl(tetrahydropyridine)carboxylate;           tert- butyl(dihydropyridine)carboxylate; dihydrothiopyranyl; methyltetrahydropyridinyl; (methylsulfonyl)tetrahydropyridinyl;                      acetyltetrahydropyridinyl; (tetrahydropyridine)carboxamide;     1,1-di oxide-dihydro thiopyranyl;     phenyl; (trifluoromethoxy)phenyl; aminophenyl; / er / -butyl(phenyl)carbamate; (pyrrolidinylsulfonyl)phenyl; oxopiperidine(carbonyl)phenyl; methylpiperazinyl; (methylpiperazinyl)phenyl; isoindolyl; cyanophenyl; cyanohalophenyl; (trifluoromethyl)phenyl; (dimethylamino)phenyl; hydroxybenzyl; methoxyphenyl; biphenyl; methylphenyl; hydroxyphenyl; dihydroindenyl; benzoic acid; methylbenzoate; pyridinyl; pyrazolyl; methylpyrazolyl; furanyl; aminopyridinyl; halopyridinyl; hydroxypyridinyl; (methoxy)halopyridinyl; methoxypyridinyl; (methyl)halopyridinyl;            piperazinylpyridinyl;            pyrrolopyridinyl; (dimethylamino)pyrimidinyl;                        (cyclopropylmethyl)pyrazolyl; (morpholinoethyl)pyrazolyl;            pyrimidinyl;            aminopyrimidinyl; (methylpiperazinyl)pyridinyl; piperazinylpyrimidinyl; morpholinopyridinyl; dihalopyridinyl; methylpyridinyl; pyrrolyl; / er / -butyl(pyrrole)carboxylate; dimethylisoxazolyl; isoquinolinyl; methylindazolyl; methylthiophenyl; indazolyl; thiophenyl; cyanopyridinyl; (hydroxymethyl)pyridinyl; picolinamide; (dimethylamino)pyridinyl; dimethylpyridinyl; or (methylamino)pyridinyl, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or phenyl; morpholinyl, or piperazinyl optionally substituted with (Ci-5)alkyl; phenyl; -C(=O)Rn; or -S(=0)2R12, R7 represents methyl optionally substituted with -OH; phenyl optionally substituted with halogen; or -C(=O)R13, R9 represents phenyl optionally substituted with -NH2, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, phenyl, or hydroxyphenyl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with phenyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; morpholinyl; methylpiperidinyl; oxopyrrolidinyl; oxoimidazolidinyl; pyrrolidinyl; piperidinyl; tetrahydrofuranyl; tetrahydropyranyl; methyltetrahydropyranyl; aminopyrrolidinyl; methylpyrrolidinyl; phenyl; pyridinyl; oxazolyl; pyridazinyl; methylisoxazolyl; methyloxazolyl; isoxazolyl; methylpyridinyl; furanyl; or hydroxypyrimidinyl, R12 represents (Ci-5)alkyl; phenyl; methylphenyl; or (methyl)halophenyl, Ru represents oxopiperidinyl; -NH2; or -OH. Throughout the present specification, the concepts defined as follows are used when defining the compounds of Formula (I) and Formula (lb). The following definitions are also applied to the terms used either individually or as a part of a larger group thereof throughout the present specification, unless otherwise particularly indicated. The term “alkyl” means a linear or branched or cyclic hydrocarbon radical respectively, each carbon atom maybe arbitrarily substituted with at least one of cyano, hydroxy, alkoxy, oxo, halogen, carbonyl, sulfonyl, cyanyl, and the like, but is not limited thereto. The term “cycloalkyl” means a saturated monocyclic hydrocarbon ring, and maybe arbitrarily fused with an aryl. For example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like, but is not limited thereto. The term “cycloalkenyl” means an unsaturated carbocyclic moiety such as cyclopentenyl, cyclohexenyl, cycloheptenyl, etc. Cycloalkenyl may include one double bond of two carbons which form the ring. The cycloalkenyl moiety may be attached in a spirocycle fashion such as spirocyclopropyl. The term “alkoxy” refers to -O-alkyl, wherein alkyl is as defined above. An examples of such groups include methoxy, ethoxy, n -propoxy, iso-propoxy, n -butoxy, 2-butoxy, n -pentoxy, / -butoxy and the like, but is not limited thereto. The term “n-membered ring” means a n-membered saturated or unsaturated carbon ring in which one or more than carbon atom may be optionally replaced with heteroatom (such as N, O, S); the n-membered saturated or unsaturated carbon ring may optionally comprise one or more C(=O) (n may be 4 to 6). For example, pyrrolidine, i / / -pyrrole-2,5-dione, i,5-dihydro-2 / / -pyrrol-2-one, and the like, but is not limited thereto. The term “heterocycloalkyl” means a form which includes 1 to 4 heteroatoms selected from N, O and S; “heterocycloalkyl” is saturated or partially saturated (partially unsaturated) or aromatic; “heterocycloalkyl” may arbitrarily comprise one or more -C(=O-) or -S(=0)2-. An appropriate heterocycloalkyl may include, for example azetidinyl; pyrrolidinyl; piperidinyl; tetrahydropyridinyl; oxopyrrolidinyl; oxopiperazinyl; morpholinyl; thiomorpholinyl; piperazinyl; dihydropyranyl; dihydrothiopyranyl; i,i-dihydrothiopyran-i,i-dioxide; isoindolyl; pyridinyl; pyrazolyl; pyrimidinyl; pyrrolyl; isoquinolinyl; indazolyl; thiophenyl; oxoimidazolidinyl; tetrahydrofuranyl; tetrahydropyranyl; oxazolyl; pyridazinyl; isoxazolyl; oxopiperidinyl and the like, but is not limited thereto. The term “halo(gen)” means a substituent selected from fluoro (F), chloro (Cl), bromo (Br) and iodo (I). The term “aryl” means an aromatic group including phenyl, naphthyl, etc., but is not limited thereto; and is arbitrarily fused with cycloalkyl such as dihydroindenyl etc. The term “heteroaryl” refers to a 5- to 7-membered aromatic, monocyclic ring, which includes at least one heteroatom, for example, 1 to 4, or in some exemplary embodiments 1 to 3 heteroatoms selected from N, O and S, and in which remaining ring atoms are carbons; a 8- to 12-membered bicyclic ring, which includes at least one heteroatom, for example, 1 to 4, or in some exemplary embodiments 1 to 3 heteroatoms selected from N, O and S, and in which remaining ring atoms are carbons, at least one ring is aromatic; For example of a heteroaryl group includes pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, imidazolyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, thienyl, benzothienyl, furyl, benzofuryl, benzoimidazolyl, indolyl, indolinyl, pyrrolyl, thiophenyl, pyridizinyl, triazolyl, quinolinyl, pyrazolyl, pyrrolopyridinyl, pyrazolopyridinyl, benzoxazolyl, benzothiazolyl, indazolyl and 5,6,7,8- tetrahydroisoquinoline, and the like, but is not limited thereto. The term “amino” as used herein refers to the group -NH2. Other terms and abbreviations used in the present specification have their original meanings, unless otherwise defined. In the present invention, representative examples of the compound represented by the formula i above are as follows. 1) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide 2) (S)-N-(5-amino-3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 3) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-(dimethylamino)-iH-indol-7-yl)acetamide 4) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-methoxy-lH-indol-7-yl)acetamide 5) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-6-(dimethylamino)-iH-inden-7-yl)-2-(3-((2-((2,2,2-trifluoroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 6) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-6-methoxy-iH-indol-7-yl)-2-(3-((2-((2,2,2- trifluoroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 7) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)acetamide 8) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-fluoropyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 9) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide io) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide n) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-ethylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 12) (S)-N-(3-(5-cyclopropyl-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 13) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)-iH-indol-7-yl)acetamide 14) (S)-2-(3-((3-(cyclopropylamino)-i,2,4-triazin-5-yl)oxy)pyrrolidin-i-yl)-N- (3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)- iH-indol-7-yl)acetamide 15) (S)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)pyrrolidin-i-yl)acetamide 16) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 17) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(5-methyl-2-((5-methyl-i-(2-morpholinoethyl)-iH-pyrazol-3- yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)acetamide 18) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyri din-4-yloxy)pyrrolidin-i-yl)acetamide 19) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 20) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-oxoacetamide 21) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-N-methyl-2-(3-(pyrimidin-4-yloxy)pyrrolidin-i-yl)acetamide 22) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(pyrrolidin-i-yl)propanamide 23) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-(pyridin-4-yloxy)pyrrolidin-i-yl)propanamide 24) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-methyl-2-(pyrrolidin-i-yl)propanamide 25) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-methyl-2-(3-(pyri din-4 -yloxy)pyrrolidin-i-yl)propanamide 26) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-hydroxyazetidin-i-yl)acetamide 27) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylmethoxy)azetidin-i-yl)acetamide 28) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyri din-4-yloxy)azetidin-i-yl)acetamide 29) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)azetidin-i-yl)acetamide 30) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)azetidin-i-yl)acetamide 31) methyl 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3- carboxylate 32) 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3-carboxylic acid 33) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxamide 34) 2-(5,6-dihydro-[4,4'-bipyridin]-i(2H)-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 35) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(i-methyl-iH-pyrazol-4-yl)-5,6-dihydropyridin-i(2H)-yl)acetamide 36) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(4-methylpiperazin-i-yl)piperidin-i-yl)acetamide 37) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-morpholinopiperi din-i-yl)acetamide 38) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyridin-3-yloxy)piperidin-i-yl)acetamide 39) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyridin-2-yloxy)piperidin-i-yl)acetamide 40) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyri din-4-yloxy)piperidin-i-yl)acetamide 41) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(pyrimidin-2-yloxy)piperidin-i-yl)acetamide 42) N-(3-(2-((i, 5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-((4,6-dimethylpyrimidin-2-yl)oxy)piperidin-i-yl)acetamide 43) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperi din-4-yl)oxy)isoxazole-5-carboxamide 44) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperi din-3-yl)oxy)isoxazole-5-carboxamide 45) 2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 46) (R)-2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 47) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-ylamino)pyrrolidin-i-yl)acetamide 48) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-ylamino)pyrrolidin-i-yl)acetamide 49) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylamino)pyrrolidin-i-yl)acetamide 50) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((3R4S)-3-fluoro-4-hydroxypyrrolidin-i-yl)acetamide 51) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3R,4R)-3-fluoro-4-(pyri din-4 -yloxy)pyrrolidin-i-yl)acetamide 52) 2-((3R,4S)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 53) 2-((3R,4R)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 54) 2-((38,4R)-3-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 55) methyl (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH- indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylate 56) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylic acid 57) 2-((28,4S)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-2-(hydroxymethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 58) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxamide 59) 2-((28,4S)-2-(aminomethyl)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 60) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 61) (S)-2-(4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 62) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yl)acetamide 63) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrrolidin-i-yl)acetamide 64) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 65) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(4-methylpiperazine-i-carbonyl)pyrroli din-1-yl)acetamide 66) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yl)acetamide 67) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrrolidin-i-yl)acetamide 68) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 69) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(i,2,3,6-tetrahydropyridine-i-carbonyl)pyrrolidin-i-yl)acetamide 70) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 71) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 72) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 73) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 74) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 75) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)pyrrolidin-i-yl)acetamide 76) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 77) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 78) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)pyrrolidin-i-yl)acetamide 79) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrazin-2-yloxy)pyrrolidin-i-yl)acetamide 80) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-(4-fluorophenoxy)pyrrolidin-i-yl)acetamide 81) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(3-fluorophenoxy)pyrrolidin-i-yl)acetamide 82) (S)-2-(3-(4-chlorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 83) (8)-2-(3-(2,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 84) (8)-2-(3-(3,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 85) (S)-2-(3-(2-chloro-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 86) (8)-2-(3-(3,5-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 87) (S)-2-(3-(3-amino-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 88) (S)-2-(3-(3-(diethylamino)phenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 89) (S)-2-(3-(3-aminophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 90) (S)-2-(3-((2-aminopyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5- dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 91) (S)-2-(3-((2-chloropyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 92) (S)-2-(3-((6-aminopyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 93) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 94) (S)-2-(3-((6-chloro-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 95) (S)-2-(3-((2-amino-6-methylpyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 96) (S)-2-(3-((5-amino-2-chloropyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 97) (S)-2-(3-((5-bromo-2-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 98) (S)-2-(3-((2-amino-6-(5-chloro-2-fluorophenyl)pyrimi din-4 - yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 99) (S)-2-(3-((2-amino-6-(trifluoromethyl)pyrirnidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 100) (S)-2-(3-([i,i'-biphenyl]-4-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7- yl)acetamide 101) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-(2-phenylpropan-2-yl)phenoxy)pyrrolidin-i-yl)acetamide 102) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-pentylpyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 103) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-((4-methylpiperazin-i-yl)methyl)phenoxy)pyrrolidin-i-yl)acetamide 104) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-5-yl)oxy)pyrroli din-1-yl)acetamide 105) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 106) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)benzo[b]thiophene-2-carboxylate 107) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxylate 108) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxylic acid 109) (S)-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)thiophene-2-carboxamide no) (S)-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N-methylthiophene-2-carboxamide in) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)thiophene-2-carboxamide 112) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-methylisoxazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 113) (S)-2-(3-(benzo[d]isoxazol-3-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 114) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(isothiazol-3-yloxy)pyrrolidin-i-yl)acetamide 115) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-methylthiophen-3-yl)oxy)pyrrolidin-i-yl)acetamide 116) (S)-2-(3-((iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl- iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 117) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-5-(trifluoromethyl)-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 118) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(isoxazol-3-yloxy)pyrrolidin-i-yl)acetamide 119) (S)-2-(3-((5-amino-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 120) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-iH-pyrrole-2-carboxylate 121) ethyl (8)-5-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)isoxazole-4-carboxylate 122) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)isoxazole-5-carboxamide 123) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N-methylisoxazole-5-carboxamide 124) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)isoxazole-5-carboxamide 125) (S)-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N,N-dimethylisoxazole-5-carboxamide 126) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-5-carboxamide 127) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-4-carboxamide 128) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)pyrimidine-4-carboxylic acid 129) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)pyrimidine-4-carboxamide 130) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N-methylpyrimidine-4-carboxamide 131) (8)-2-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N,N-dimethylpyrimidine-4-carboxamide 132) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)pyrazine-2-carboxamide 133) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl) oxy)-N-methylpyrazine- 2 -carboxamide 134) (S)-2-(3-((4-amino-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 135) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 136) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 137) (S)-2-(3-((4-(cyclopropylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N- (3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)acetamide 138) (8)-2-(3-((4,6-diamino-i,3,5-triazin-2-yl)oxy)pyrroli din-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 139) (S)-2-(3-((4-amino-6-(pyrrolidin-i-yl)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 140) (S)-2-(3-((6-aminopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 141) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(methylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 142) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 143) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrimi din-4-yl)oxy)pyrroli din-i-yl)acetamide 144) (S)-2-(3-((6-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 145) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 146) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((3-hydroxypropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 147) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-methoxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 148) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((3-(dimethylarnino)propyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 149) (S)-2-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 150) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(phenethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 151) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 152) (S)-2-(3-((6-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 153) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(dimethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 154) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(methyl)amino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 155) (S)-2-(3-((6-(diethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 156) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(propyl)amino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 157) (S)-2-(3-((6-(butyl(ethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 158) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(pyrrolidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 159) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((3S)-3-((6-(3-hydroxypyrrolidin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 160) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-((6-((R)-3-hydroxypyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 161) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-((6-((S)-3-hydroxypyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 162) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(piperidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 163) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-hydroxypiperi din-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 164) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-morpholinopyrimi din-4-yl)oxy)pyrroli din-1-yl)acetamide 165) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 166) (S)-2-(3-((2-amino-6-(methylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 167) (S)-2-(3-((2-amino-6-(pyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrroli din-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 168) (S)-2-(3-((4-aminopyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 169) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 170) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 171) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 172) (S)-2-(3-((4-(diethylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 173) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(pyrrolidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 174) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(piperidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 175) (S)-2-(3-((4-(cyclopropylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 176) (S)-2-(3-((4-amino-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 177) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(methylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 178) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 179) (S)-2-(3-((4-(cyclopropylamino)-5-fluoropyrimidin-2-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 180) (S)-2-(3-((4-(cyclohexylamino)-5-fluoropyrimidin-2-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 181) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 182) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 183) (S)-2-(3-((4-(diethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 184) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(rnethyl(phenyl)amino)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 185) (S)-2-(3-((4-(benzyl(methyl)amino)-5-fluoropyrimidin-2- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 186) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(pyrrolidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 187) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(piperidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 188) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-morpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 189) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-thiomorpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 190) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(4-methylpiperazin-i-yl)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 191) (S)-2-(3-((4-(cyclopropylamino)-5-methylpyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 192) (S)-2-(3-((2-aminopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 193) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylthio)pyrimidin-4-yl)oxy)pyrroli din-1-yl)acetamide 194) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-methoxypyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 195) (S)-2-(3-((2-(benzyloxy)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 196) (S)-2-(3-((2-acetamidopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 197) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 198) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2,2,2-trifluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 199) (8)-2-(3-((2-((2,2-difluoropropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 200) (8)-2-(3-((2-((2,2-difluoroethyl)amino)pyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 201) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-((3S)-3-((2-((i,i,i-trifluoropropan-2-yl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 202) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-fluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 203) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(ethylamino)pyrimidin-4-yl)oxy)pyrroli din-1-yl)acetamide 204) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(propylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 205) (S)-2-(3-((2-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 206) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((3-hydroxypropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 207) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 208) (S)-2-(3-((2-(cyclobutylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 209) (S)-2-(3-((2-(cyclopentylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 210) (S)-2-(3-((2-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 211) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(isopropylamino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 212) 2-((3S)-3-((2-(sec-butylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 213) (S)-2-(3-((2-((cyclopropylmethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 214) (S)-2-(3-((2-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 215) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 216) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-rnethoxyethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 217) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-(dimethylarnino)ethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 218) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((3-(dimethylarnino)propyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 219) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methoxyamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 220) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 221) (S)-2-(3-((2-(benzyl(methyl)amino)pyrirnidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 222) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyrrolidin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 223) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(piperidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide. 224) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 225) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 226) (S)-2-(3-((2-amino-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 227) (S)-2-(3-((2-(cyclopropylamino)-5-fluoropyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 228) (S)-2-(3-((2-(cyclohexylamino)-5-fluoropyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 229) (S)-2-(3-((2-((cyclopropylmethyl)amino)-5-fluoropyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 230) (S)-2-(3-((2-(benzylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)- iH-indol-7-yl)acetamide 231) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 232) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 233) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 234) (S)-2-(3-((2-(cyclopropylamino)-6-fluoropyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 235) (S)-2-(3-((2-(cyclopropylamino)-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 236) (S)-2-(3-((2-(cyclopropylamino)-6-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 237) (S)-2-(3-((2-(cyclopropylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 238) (S)-2-(3-((2-(cyclopropylamino)-6-methoxypyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 239) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-(dimethylamino)ethyl)amino)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 240) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 241) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 242) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 243) (S)-2-(3-((6-(cyclopropylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 244) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 245) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 246) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 247) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-(dirnethylamino)ethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 248) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-phenylpyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 249) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(i-methyl-iH-pyrazol-4-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 250) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4,4-dimethylcyclohex-i-en-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 251) (8)-2-(3-((6-(3,6-dihydro-2H-pyran-4-yl)pyrimi din-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 252) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(4,4-dimethylcyclohex-i-en-i-yl)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 253) (8)-2-(3-((4-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 254) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-phenylpyrimidin-2-yl)oxy)pyrroli din-1-yl)acetamide 255) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyridin-3-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 256) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyridin-4-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 257) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-phenylpyrimidin-5-yl)oxy)pyrroli din-1-yl)acetamide 258) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-3-yl)pyrimidin-5-yl)oxy)pyrroli din-1-yl)acetamide 259) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-4-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 260) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 261) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-fluoroisoindoline-i, 3-dione 262) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 263) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindoline-i,3-dione 264) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-nitroisoindoline-i,3-dione 265) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 266) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 267) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindolin-i-one 268) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-nitroisoindolin-i-one 269) 6-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 270) 5-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 271) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-nitroisoindolin-i-one 272) 4-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 273) 7-chloro-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 274) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitroisoindolin-i-one 275) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodoisoindolin-i-one 276) 7-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 277) 7-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 278) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-iodoisoindolin-i-one 279) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-methoxyisoindolin-i-one 280) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4,6-dimethoxyisoindolin-i-one 281) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindolin-i-one 282) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 283) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-rnethylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 284) 6-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 285) 3-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 286) 4-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 287) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-3-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyri din-7-one 288) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 289) 7-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 290) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 291) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-5-yl)cyclopropanecarboxamide 292) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)cyclohexanecarboxamide 293) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzamide 294) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzamide 295) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohexanecarboxamide 296) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)morpholine-4-carboxamide 297) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 298) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)nicotinamide 299) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-4-carboxamide 300) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopropanecarboxamide 301) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isonicotinamide 302) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyridazine-4-carboxamide 303) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohexane-i-carboxamide 304) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(3-hydroxyphenyl)acetamide 305) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-phenylacetamide 306) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-4-carboxamide 307) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-3-carboxamide 308) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 309) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohex-3-ene-i-carboxamide 310) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopent-3-ene-i-carboxamide 311) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylcyclopent-3-ene-i-carboxamide 312) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cycloheptanecarboxamide 313) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-oxoimidazolidine-i-carboxamide 314) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2,3-dihydro-iH-indene-2-carboxamide 315) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 316) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 317) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 318) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 319) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)piperidine-3-carboxamide 320) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-oxocyclohexane-i-carboxamide 321) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-4-carboxamide 322) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methyloxazole-4-carboxamide 323) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-5-carboxamide 324) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isoxazole-3-carboxamide 325) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-3-carboxamide 326) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydrofuran-3-carboxamide 327) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-3-carboxamide 328) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methyltetrahydro-2H-pyran-4-carboxamide 329) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylcyclohexane-i-carboxamide 330) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohex-3-ene-i-carboxamide 331) (2R,4S)-4-amino-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-2-carboxamide 332) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylpiperidine-3-carboxamide 333) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpyrrolidine-3-carboxamide 334) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylnicotinamide 335) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(dimethylamino)acetamide 336) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopentanecarboxamide 337) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-4-carboxamide 338) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)furan-3-carboxamide 339) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-6-hydroxypyrimidine-4-carboxamide 340) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzenesulfonamide 341) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzenesulfonamide 342) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)methanesulfonamide 343) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylbenzenesulfonamide 344) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)propane-2-sulfonamide 345) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-fluoro-3-methylbenzenesulfonamide 346) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(phenylamino)isoindolin-i-one 347) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-morpholinoisoindolin-i-one 348) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(4-methylpiperazin-i-yl)isoindolin-i-one 349) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)isoindolin-i-one 350) 7-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 351) 7-((cyclopropylmethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 352) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-morpholinoisoindolin-i-one 353) 4-((cyclopropylrnethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 354) 4-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 355) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(phenylethynyl)isoindolin-i-one 356) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(phenylethynyl)isoindolin-i-one 357) 4-((4-aminophenyl)ethynyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 358) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 359) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 360) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 361) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methylacrylamide 362) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-4-(3-oxobut-i-en-i-yl)isoindolin-i-one 363) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-methylacrylamide 364) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethylacrylamide 365) (E)-N-cyclopropyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 366) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylohydrazide 367) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylic acid 368) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-diethylacrylamide 369) (E)-N,N-dibutyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 370) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-isopropylacrylamide 371) (E)-N-(tert-butyl)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 372) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-hydroxyethyl) acrylamide 373) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-propylacrylamide 374) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-methoxyethyl)acrylamide 375) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-hydroxyprop-i-en-i-yl)isoindolin-i-one 376) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethyl-2-methylacrylamide 377) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-phenylisoindolin-i-one 378) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-phenylisoindolin-i-one 379) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-phenylisoindolin-i-one 380) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(pyridin-4-yl)isoindolin-i-one 381) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-6-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 382) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-phenylisoindolin-i-one 383) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)isoindolin-i-one 384) 7-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 385) 7-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 386) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(iH-pyrazol-4-yl)isoindolin-i-one 387) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)isoindolin-i-one 388) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)isoindolin-i-one 389) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-pyrazol-4-yl)isoindolin-i-one 390) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrazol-4-yl)isoindolin-i-one 391) 4-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 392) 4-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 393) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(furan-3-yl)isoindolin-i-one 394) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 395) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(trifluoromethoxy)phenyl)isoindolin-i-one 396) 4-(4-aminophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 397) tert-butyl 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6- dihydropyridine-i(2H)-carboxylate 398) / er / -butyl (4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)phenyl)carbamate 399) 4-(2-aminopyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 400) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-fluoropyridin-4-yl)isoindolin-i-one 401) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-hydroxypyridin-3-yl)isoindolin-i-one 402) 4-(2-chloropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)- 5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 403) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoro-2-methoxypyridin-4-yl)isoindolin-i-one 404) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-4-yl)isoindolin-i-one 405) 4-(6-chloropyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 406) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-methoxypyridin-3-yl)isoindolin-i-one 407) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-fluoro-5-methylpyridin-3-yl)isoindolin-i-one 408) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyri din-4-yl)isoindolin-i-one 409) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(pyrrolidin-i-ylsulfonyl)phenyl)isoindolin-i-one 410) (£)-2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-4-(3-fluorostyryl)isoindolin-i-one 411) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrolo[2,3-b]pyridin-4-yl)isoindolin-i-one 412) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-oxopiperidine-i-carbonyl)phenyl)isoindolin-i-one 413) 4-(3,6-dihydro-2H-thiopyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 414) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyrimidin-5-yl)isoindolin-i-one 415) 4-(i-(cyclopropylmethyl)-iH-pyrazol-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 416) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(2-morpholinoethyl)-iH-pyrazol-4-yl)isoindolin-i-one 417) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-5-yl)isoindolin-i-one 418) 4-(2-aminopyrimidin-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 419) 4-(5-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 420) 4-(6-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 421) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-4-yl)isoindolin-i-one 422) 4-(2-aminopyrimi din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 423) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)pyridin-2-yl)isoindolin-i-one 424) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyrimidin-5-yl)isoindolin-i-one 425) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-morpholinopyridin-3-yl)isoindolin-i-one 426) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)phenyl)isoindolin-i-one 427) 4-(2,6-difluoropyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 428) 4-(3,5-difluoropyridin-4-yl)-2-(3-(2-((i, 5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 429) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)isoindolin-i-one 430) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-[4,5'-biisoindolin]-i-one 431) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-3-yl)isoindolin-i-one 432) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzonitrile 433) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-fluorobenzonitrile 434) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(trifluoromethyl)phenyl)isoindolin-i-one 435) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-3-yl)isoindolin-i-one 436) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(dimethylamino)phenyl)isoindolin-i-one 437) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)phenyl)isoindolin-i-one 438) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxyphenyl)isoindolin-i-one 439) 4-([i,i'-biphenyl]-2-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 440) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(o-tolyl)isoindolin-i-one 441) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxyphenyl)isoindolin-i-one 442) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrol-2-yl)isoindolin-i-one 443) / er / -butyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-iH-pyrrole-i-carboxylate 444) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3,5-dimethylisoxazol-4-yl)isoindolin-i-one 445) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-4-yl)isoindolin-i-one 446) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxypyri din-4-yl)isoindolin-i-one 447) 4-(3-aminopyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 448) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(isoquinolin-7-yl)isoindolin-i-one 449) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-5-yl)isoindolin-i-one 450) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-6-yl)isoindolin-i-one 451) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylthiophen-2-yl)isoindolin-i-one 452) 4-(2,3-dihydro-iH-inden-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 453) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-methylthiophen-3-yl)isoindolin-i-one 454) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methylpyridin-4-yl)isoindolin-i-one 455) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-methylpyri din-4-yl)isoindolin-i-one 456) 4-(6-aminopyrimidin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 457) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-indazol-4-yl)isoindolin-i-one 458) 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoic acid 460) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(hydroxymethyl)phenyl)isoindolin-i-one 461) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(thiophen-3-yl)isoindolin-i-one 462) 4-(2-aminophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 463) methyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoate 464) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 465) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(methylsulfonyl)-i,2,3,6-tetrahydropyridin-4- yl)isoindolin-i-one 466) 4-(i-acetyl-i,2,3,6-tetrahydropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 467) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6-dihydropyridine-i(2H)-carboxamide 468) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,i-dioxido-3,6-dihydro-2H-thiopyran-4-yl)isoindolin-i-one 469) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 470) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 471) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-(hydroxymethyl)pyri din-4-yl)isoindolin-i-one 472) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)pyridin-4-yl)isoindolin-i-one 473) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 474) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 475) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyridin-4-yl)isoindolin-i-one 476) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 477) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylpyridin-3-yl)isoindolin-i-one 478) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)isoindolin-i-one 479) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)isoindolin-i-one 480) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(pyridin-4-yl)isoindolin-i-one 481) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methoxypyridin-4-yl)isoindolin-i-one 482) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 483) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyridin-4-yl)-7-fluoroisoindolin-i-one 484) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-fluoropyridin-3-yl)isoindolin-i-one 485) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-fluoropyri din-4-yl)isoindolin-i-one 486) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-methylpyridin-3-yl)isoindolin-i-one 487) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(3-methylpyri din-4 -yl)isoindolin-i-one 488) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)-7-fluoroisoindolin-i-one 489) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitro-4-(pyridin-4-yl)isoindolin-i-one 490) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)-4-(pyridin-4-yl)isoindolin-i-one 491) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(methylamino)-4-(pyri din-4-yl)isoindolin-i-one 492) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodo-4-phenylisoindolin-i-one 493) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-phenyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 494) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 495) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 496) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 497) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(pyri din-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 498) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(i,2,3,6-tetrahydropyri din-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 499) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(i,2,3,6-tetrahydropyri din-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 500) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 501) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 502) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 503) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4- c]pyridin-i-one 504) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4- c]pyridin-i-one 505) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylpyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 506) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one METHOD FOR PREPARING GCN2 INHIBITOR COMPOUND Hereinafter, a method for preparing the compound represented by Formula (I) or Formula (lb), is described on the basis of an exemplary reaction formula for better understanding of the present invention. However, it should be interpreted by those skilled in the art, to which the present invention pertains, that the compound of Formula (I) or Formula (lb) maybe prepared by means of various methods based on a structure of Formula (I) and Formula (lb), and such methods are all included in the scope of the present invention. In other words, it should be appreciated that the compound according to the present invention may be prepared by arbitrarily combining various synthesis methods which are described in the present specification or disclosed in the prior art and this belongs to the scope of the present invention. In the following reaction formulas, all the substituents are the same as defined above, unless indicated otherwise. A synthesis method for the compound of the Formula (I) above according to the present invention may be indicated as an example such as a following a reaction formula 1: [Reaction Formula i] no2 TsCI, NaOH,TBAHS DCM, H2O, rt NBS DMF, 60 °C B2Pin2 PdCI2(dppf) / CH2CI2, KOAc Dimethoxyethane, 85 °C Pd(PPh3)4, K2CO3 1,4-Dioxane, H2O, 80 °C Cl Z’ Fe, NH4CI THF, H2O, 80 °C THF, 50 °C wherein, G, M, Li, L2, Yi, Z, Y3, Wi and R2 are as defined in the Formula (I); LG represents -Cl or -OH. In the Reaction Formula 1 above, an intermediate compound Y3 may be synthesized through methods of following reaction formulas 1-1,1-2, or 1-3: [Reaction Formula 1-1] [Reaction Formula 1-2] [Reaction Formula 1-3] wherein, Nu represents -NH- or -O-; A represents azetidinyl, pyrrolidinyl, piperidinyl or oxopyrrolidinyl; A' represents tetrahydropyridinyl; A" represents piperidinyl; B represents pyridinyl or methylpyrazolyl; B' represents methylpiperazinyl or morpholinyl. A synthesis method for the compound of the Formula (lb) above according to the present invention may be indicated as an example such as a following a reaction formula 2: [Reaction Formula 2] no2 TsCI, NaOH, TBAHS DCM, H2O, rt no2 NBS DMF, 60 °C B2Pin2 PdCI2(dppf) / CH2CI2, KOAc Dimethoxyethane, 85 °C Pd(PPh3)4, K2CO3 1,4-Dioxane, H2O, 80 °C NO2 Fe, NH4CI THF, H2O, 80 °C wherein, G, M, Li, L2, Vi, V2, V3, V4, W3 and X are as defined in the Formula (lb). In the Reaction Formula 2 above, an intermediate compound Br COOMe Vi, ^4 maybe W3' ^2^3 Br __^COOMe v / \v4 HN v2=vj or w3"        , which may be synthesized through methods of following Reaction Formulas 2-1 or 2-2: [Reaction Formula 2-1] Br COOMe v2=v3 h-w3' Pd, base, ligand COOMe NBS, AIBN v2=v3 MeCN, 90 °C Br COOMe W / 4 W3'^2=73 [Reaction Formula 2-2] COOMe Cl-W3" COOMe NBS, AIBN h2n v2=v3 base W HN v2=v' MeCN, 90 °C Br wherein, W3' represents -NR5R6'; -CH=CR7R8'; -OC-R9'; (C5-6)cycloalkenyl, (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein the aryl or the heteroaryl is optionally substituted with one or more R10', W3" represents -C(=O)RU'; or -S(=0)2R12', R5' and R6' each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or an aryl, R7' represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13', R8' represents H; or (Ci-5)alkyl, R9' represents an aryl optionally substituted with -NH2, one or more R10' each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring, R11' represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH, R12' represents (Ci-5)alkyl; or an aryl optionally substituted with (Ci-5)alkyl and / or halogen, R13' represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 optionally substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2, R!4' represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH. The compound of the Formula (I) and Formula (lb) according to the present invention maybe separated or purified from products of the reaction formulas 1 and 2 above by means of several methods such as crystallization, silica gel column chromatography, etc. In this way, the compound according to the present invention, as well as an initiation, an intermediate, etc., for preparing the same may be synthesized by means of various methods, and it should be understood that such methods are included in the scope of the present invention with regard to a preparation for the compound of the Formula (I) and Formula (lb). COMPOSITION CONTAINING GCN2 INHIBITOR COMPOUND, AND USE THEREOF The present invention provides a pharmaceutical composition and a use of treating or preventing GCN2 activation-related diseases, the composition including a compound represented by the following Formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof or a solvate thereof as an active ingredient: [Formula (I)] Formula (I) is the same as defined above. The compound represented by formula (I) above may be a compound represented by a following formula (lb): [Formula (lb)] Formula (lb) is the same as defined above. The compound of Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or the solvate thereof has a remarkable effect on preventing or treating GCN2 activation-related diseases by showing GCN2 inhibitory activity. Thus, achieving a remarkable effect of preventing or treating GCN2 activation-related diseases. In the present invention, the said GCN2 activation-related diseases means diseases associated with enhanced activity of GCN2 and comprise a cancer, a neurodegenerative disease, a chronic infection, a metabolic disease such as hepatic steatosis, and the cancer comprises thyroid cancer, melanoma, prostate cancer, endometrial cancer, lung cancer, head and neck cancer, pancreatic cancer, glioma, stomach cancer, urothelial cancer, skin cancer, breast cancer, colorectal cancer, renal cancer, fibrosarcoma, bone sarcoma, connective tissue sarcoma, giant cell carcinoma, squamous cell carcinoma, leukemia, skin cancer, soft tissue cancer, liver cancer, adenocarcinoma, hepatocellular carcinoma, multiple myeloma, myelodysplastic syndrome, myeloproliferative neoplasm, malignant glioma, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, Burkitt’s lymphoma, chronic lymphocytic leukemia, chronic myeloid leukemia, hairy cell leukemia, plasmacytoma, lymphoplasmacytic lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, large granular lymphocytic leukemia, B-cell prolymphocytic leukemia, T-cell prolymphocytic leukemia, small cell lung cancer, pediatric neuroblastoma or symptoms related thereto. In the present invention, pharmaceutically acceptable salt mean the salt conventionally used in a pharmaceutical industry, for example, acid salt prepared from i-hydroxy-2-naphthoic acid, 2,2-dichloroacetic acid, 2-hydroxyethanesulfonic acid, 2-oxoglutaric acid, 4-acetamidobenzoic acid, 4-aminosalicylic acid, acetic acid, adipic acid, L-ascorbic acid, L-aspartic acid, benzenesulfonic acid, benzoic acid, (+)-camphoric acid, (+)-camphor-io-sulfonic acid, capric acid, caproic acid, caprylic acid, carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, D-glucoheptonic acid, D-gluconic acid, D-glucuronic acid, glutamic acid, glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, hydrobromic acid, hydrochloric acid, isobutyric acid, lactic acid, lactobionic acid, lauric acid, maleic acid, L-malic acid, malonic acid, mandelic acid, methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, nicotinic acid, nitric acid, oleic acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid, proprionic acid, L-pyroglutamic acid, salicylic acid, sebacic acid, stearic acid, succinic acid, sulfuric acid, L-tartaric acid, thiocyanic acid, toluenesulfonic acid, undecylenic acid or other compounds that can be used as acids, and the like. For its administration, the pharmaceutical composition of the present invention may further contain at least one type of a pharmaceutically acceptable carrier, in addition to the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof, and may be also used with the addition of other conventional additives such as antioxidants, buffer solutions, bacteriostatic agents, etc., if needed. Also, such pharmaceutical composition may be formulated such a way that diluents, dispersing agents, surfactants, binders and lubricants are additionally added thereto. The composition of the present invention may be orally or parenterally administered (for example, applied intravenously, hypodermically, intraperitoneally or locally) according to an intended method, in which a dosage thereof varies in a range thereof depending on a patient’s weight, age, gender, health condition and diet, an administration time, an administration method, an excretion rate, a severity of a disease and the like. A daily dosage of the compound represented by the formula (I) or (lb) is about o.ooi to 1000 mg / kg and maybe administered once a day or divided into several times. In addition to the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof, said pharmaceutical composition of the present invention may further contain at least one therapeutic agent as an active ingredient which show a medicinal effect the same thereto or similar thereto. Therapeutic agents may selected from the group consisting of chemotherapy agent, radiotherapy agent, immunotherapy agent and tumor microenvironment modulating agent. According to the present invention, the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof show GCN2 inhibition activity, thus achieving a remarkable effect of preventing or treating GCN2 activation-related diseases. According to one specific embodiment of the present invention, the present invention provides a method for preventing or treating GCN2 activation-related diseases, including administering a therapeutically effective amount of the compound represented by Formula (I) or (lb), the stereoisomers thereof, the pharmaceutically acceptable salt thereof or solvate thereof into a subject. The method for preventing or treating GCN2 activation-related diseases according to the present invention includes not only dealing with the cancer themselves before expression of their symptoms, but also inhibiting or avoiding such symptoms by administering the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof. According to one specific embodiment of the present invention, the present invention provides a use of the compound represented by the formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or the solvate thereof in preparation of a medicament for treating GCN2 activation-related diseases. For preparing a medicament, the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof may be combined with acceptable adjuvants, diluents, carriers, etc., and may be prepared into a complex preparation together with other active agents (therapeutic agents) and thus have a synergy action of active components. According to one specific embodiment of the present invention, the present invention also provides a method for inhibiting GCN2 activity, wherein the method comprises administering a therapeutically effective dose of the formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or the solvate thereof into a subject. As used herein, the “subject” means mammals including humans, and the “administration” means providing a predetermined material to a patient by means of any appropriate method. As used herein, the term “therapeutically effective amount” refers to an amount of the compound represented by Formula (I) or (lb), the stereoisomer thereof, the pharmaceutically acceptable salt thereof or solvate thereof, which are effective in preventing or treating GCN2 activation-related diseases. (1) The present invention provides a compound represented by a following Formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof: [Formula (I)] Wherein, L1 and L2 each independently represent H; (Ci-5)alkyl optionally substituted with 4- to 6-membered heterocycloalkyl; or L1 and L2 are connected to form a 5- to 6membered ring, M represents H; halogen; (Ci-5)alkyl; (C3-7)cycloalkyl; or (Ci-5)alkoxy, G represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; or -NH2, wherein at least one H of -NH2 is optionally substituted with (Ci-5)alkyl, Y1 represents H; or (Ci-5)alkyl, Z represents -C(=O)-; or -CH2- optionally substituted with one or more (Ci-5)alkyl; or Z is connected to Y1 to form a 5- to 6-membered ring, Y3 represents 4- to 6-membered heterocycloalkyl in which at least one H is optionally and each independently substituted with W1 or W2; or Y3 is connected to Z to form an aryl or a heteroaryl in case that Z is connected to Y1 to form the 5- to 6membered ring, at least one H of the aryl and heteroaryl formed by Y3 and Z is optionally and independently substituted with W3, Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH, -NH2 or -CN; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; a heteroaryl optionally substituted with (Ci-s)alkyl; -COR1; -OR2; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with a heteroaryl, R1 represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (C3-7)cycloalkyl, R2 represents (Ci-5)alkyl optionally substituted with a heteroaryl; an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally and each independently substituted with one or more R2a, one or more R2a each independently represents halogen; (Ci-5)alkyl optionally substituted with an aryl, or 5- to 7- membered heterocycloalkyl substituted with (Ci-5)alkyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7- membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -OH; -CF3; (Ci-5)alkoxy optionally substituted with an aryl; an aryl in which at least one H of the aryl is optionally and each independently substituted with halogen; a heteroaryl optionally substituted with (Ci-5)alkyl; thio(Ci-5)alkyl; -CORla; or NR3R4, Rla is represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (C3-7)cycloalkyl, R3 and R4 each independently represent H; halogen; (Ci-5)alkyl optionally substituted with halogen, -CF3, -OH, (Ci-5)alkoxy, -N-[(Ci-5)alkyl][(Ci-5)alkyl], an aryl or (C3-7)cycloalkyl; (C3-7)cycloalkyl; (Ci-5)alkoxy; an aryl; or -C(=O)(Ci-5)alkyl, and one or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally substituted with one or more R10, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12, R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13, R8 represents H; or (Ci-5)alkyl, R9 represents an aryl optionally substituted with -NH2, one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH, R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen, R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2, Ru represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH. (2) The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof or the solvate thereof according to (1), wherein: Y3 represents azetidinyl; pyrrolidinyl; piperidinyl; tetrahydropyridinyl; or oxopyrrolidinyl, which is optionally substituted with W1 and W2, Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH or -CN; methylpiperazinyl; morpholinyl; pyridinyl; methylpyrazolyl; -COR1; -OR2; -NH2; -NH(pyridinyl) or -NH(pyrimidinyl), R1 represents (Ci-5)alkoxy; -OH; -NH2; -NH-(C3-7)cycloalkyl; oxopiperazinyl; morpholinyl; thiomorpholinyl; methylpiperazinyl; or tetrahydropyridinyl, R2 represents (Ci-5)alkyl optionally substituted with pyridinyl; halophenyl; dihalophenyl; (amino)halophenyl; (methylpiperazinyl)(methyl)phenyl; (dimehtylamino)phenyl; aminophenyl; diethylamino phenyl; biphenyl; (phenylpropanyl)phenyl;                           (cyclopropylamino)pyrimidinyl; (trifluoroethylamino)pyrimidinyl;         pyridinyl;                   pyrimidinyl; (cyclopropyl)(isoxazole)carboxamide; (dimethyl)pyrimidinyl; pyrazinyl; aminopyridinyl; halopyridinyl; aminopyrazinyl; halopyrimidinyl; (methyl)halopyrimidinyl; (amino)(methyl)pyrimidinyl; (amino)halopyrimidinyl; dihalopyrimidinyl;                               amino(dihalophenyl)pyrimidinyl; (amino)(trifluoromethyl)pyrimidinyl; pentylpyrimidinyl; methylpyrazolyl; methyl(benzothiophene)carboxylate;                methyl(thiophene)carboxylate; (thiophene)carboxylic               acid;                (thiophene)carboxamide; methyl(thiophene)carboxamide;              cyclopropyl(thiophene)carboxamide; methylisoxazolyl; benzoisoxazolyl; isothiazolyl; methylthiophenyl; pyrazolyl; (methyl)(trifluoromethyl)pyrazolyl; isoxazolyl; aminopyrazolyl; methyl(pyrrole)carboxylate; ethyl(isoxazole)carboxylate; (isoxazole)carboxamide; methyl(isoxazole)carboxamide; cyclopropyl(oxazole)carboxamide; (pyrimidine)carboxamide; dimethyl(pyrimidine)carboxamide; dimethyl(isoxazole)carboxamide: (pyrimidine)carboxylic           acid: methyl(pyrimidine)carboxamide: (pyrazine)carboxamide: methyl(pyrazine)carboxamide; aminotriazinyl; (methylamino)triazinyl; (dimethylamino)triazinyl; (cyclopropylamino)triazinyl; diaminotriazinyl; (amino) (pyrrolidinyl)triazinyl; aminopyrimidinyl; (methylamino)pyrimidinyl; (ethylamino)pyrimidinyl; (propylamino)pyrimidinyl; (butylamino)pyrimidinyl; (hydroxyethylamino)pyrimidinyl;               (hydroxypropylamino)pyrimidinyl; (methoxyethylamino)pyrimidinyl; (((dimethylamino)propyl)amino)pyrimidinyl; (benzylamino)pyrimidinyl;                         (phenethylamino)pyrimidinyl; (cyclohexylamino)pyrimidinyl;                        (dimethylamino)pyrimidinyl; (ethylmethylamino)pyrimidinyl;                        (diethylamino)pyrimidinyl; (ethylpropylamino)pyrimidinyl;                      (butylethylamino)pyrimidinyl; pyrrolidinylpyrimidinyl; (hydroxypyrrolidinyl)pyrimidinyl; piperidinylpyrimidinyl; (hydroxypiperidinyl)pyrimidinyl;                          morpholinopyrimidinyl; (methylpiperazinyl)pyrimidinyl;                (amino) (methylamino)pyrimidinyl; (amino)(pyrrolidinyl)pyrimidinyl;                  (methylamino)halopyrimidinyl; (ethylamino)halopyrimidinyl;                  (cyclopropylamino)halopyrimidinyl; (cyclohexylamino)halopyrimidinyl;               (dimethylamino)halopyrimidinyl; (ethylmethylamino)halopyrimidinyl;                (diethylamino)halopyrimidinyl; (methylphenylamino)halopyrimidinyl; (benzylmethylamino)halopyrimidinyl; (pyrrolidinyl)halopyrimidinyl;                         (piperidinyl)halopyrimidinyl; (morpholino)halopyrimidinyl;                   (thiomorpholino)halopyrimidinyl; (methylpiperazinyl)halopyrimidinyl;         (cyclopropylamino)methylpyrimidinyl; (amino)pyrimidinyl; (methylthio)pyrimidinyl; (methoxy)pyrimidinyl; (benzyloxy)pyrimidinyl; (difluoroethylamino)pyrimidinyl; (fluoroethylamino)pyrimidinyl; (cyclopentylamino)pyrimidinyl; butylamino)pyrimidinyl; acetamidopyrimidinyl; (difluoropropylamino)pyrimidinyl: (trifluoropropylamino)pyrimidinyl: (cyclobutylamino)pyrimidinyl: (isopropylamino)pyrimidinyl;         (sec- ((cyclopropylmethyl)amino)pyrimidinyl: (((dimethylamino)ethyl)amino)pyrimidinyl; (((dimethylamino)propyl)amino)pyrimidinyl;         (methoxyamino)pyrimidinyl; (benzylmethylamino)pyrimidinyl;               (cyclohexylamino)halopyrimidinyl; (cyclopropylmethylamino)halopyrimidinyl;         (benzylamino)halopyrimidinyl; (cyclopropylamino)halopyrimidinyl;         (cyclopropylamino)methylpyrimidinyl; (cyclopropylamino)(trifluoromethyl)pyrimidinyl; (cyclopropylamino)(methoxy)pyrimidinyl;            (cyclopropylamino)pyrazinyl; (ethylamino)pyrazinyl; (propylamino)pyrazinyl; (hydroxyethylamino)pyrazinyl; (((dimethylamino)ethyl)amino)pyrazinyl;                       phenylpyrimidinyl; (methylpyrazolyl)pyrimidinyl;                  (dimethylcyclohexenyl)pyrimidinyl; dihydropyranylpyrimidinyl; or pyridinylpyrimidinyl. (3) The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1) or (2), wherein the compound represented by formula (I) above is a compound represented by a following Formula (lb): [Formula (lb)] In Formula (lb), X represents -CH2-; or -C(=O)-, V1, V2, V3 and V4 each independently represent CH or N, wherein one or more H of V1, V2, V3 and V4 is optionally and each independently substituted with W3 in case that all of V1, V2, V3 and V4 are not N, one or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci- 5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein the aryl or the heteroaryl is optionally substituted with one or more R10, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12, R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13, R8 represents H; or (Ci-5)alkyl, R9 represents an aryl optionally substituted with -NH2, one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH, R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen, R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 optionally substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2, Ru represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH, L1, L2, M, and G are as defined in (1) or (2). (4) The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2) or (3), W3 independently represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; morpholinyl; tetrahydropyridinyl; dihydropyranyl;            / er / -butyl(tetrahydropyridine)carboxylate;           tert- butyl(dihydropyridine)carboxylate; dihydrothiopyranyl; methyltetrahydropyridinyl; (methylsulfonyl)tetrahydropyridinyl;                      acetyltetrahydropyridinyl; (tetrahydropyridine)carboxamide;     1,1-di oxide-dihydro thiopyranyl;     phenyl; (trifluoromethoxy)phenyl; aminophenyl; / er / -butyl(phenyl)carbamate; (pyrrolidinylsulfonyl)phenyl; oxopiperidine(carbonyl)phenyl; methylpiperazinyl; (methylpiperazinyl)phenyl; isoindolyl; cyanophenyl; cyanohalophenyl; (trifluoromethyl)phenyl; (dimethylamino)phenyl; hydroxybenzyl; methoxyphenyl; biphenyl; methylphenyl; hydroxyphenyl; dihydroindenyl; benzoic acid; methylbenzoate; pyridinyl; pyrazolyl; methylpyrazolyl; furanyl; aminopyridinyl; halopyridinyl; hydroxypyridinyl; (methoxy)halopyridinyl; methoxypyridinyl; (methyl)halopyridinyl;            piperazinylpyridinyl;            pyrrolopyridinyl; (dimethylamino)pyrimidinyl;                        (cyclopropylmethyl)pyrazolyl; (morpholinoethyl)pyrazolyl;            pyrimidinyl;            aminopyrimidinyl; (methylpiperazinyl)pyridinyl; piperazinylpyrimidinyl; morpholinopyridinyl; dihalopyridinyl; methylpyridinyl; pyrrolyl; / er / -butyl(pyrrole)carboxylate; dimethylisoxazolyl; isoquinolinyl; methylindazolyl; methylthiophenyl; indazolyl; thiophenyl; cyanopyridinyl; (hydroxymethyl)pyridinyl; picolinamide; (dimethylamino)pyridinyl; dimethylpyridinyl; or (methylamino)pyridinyl, Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or phenyl; morpholinyl, or piperazinyl optionally substituted with (Ci-5)alkyl; phenyl; -C(=O)Rn; or -S(=0)2R12, R7 represents methyl optionally substituted with -OH; phenyl optionally substituted with halogen; or -C(=O)R13, R9 represents phenyl optionally substituted with -NH2, R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, phenyl, or hydroxyphenyl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with phenyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; morpholinyl; methylpiperidinyl; oxopyrrolidinyl; oxoimidazolidinyl; pyrrolidinyl; piperidinyl; tetrahydrofuranyl; tetrahydropyranyl; methyltetrahydropyranyl; aminopyrrolidinyl; methylpyrrolidinyl; phenyl; pyridinyl; oxazolyl; pyridazinyl; methylisoxazolyl; methyloxazolyl; isoxazolyl; methylpyridinyl; furanyl; or hydroxypyrimidinyl, R12 represents (Ci-5)alkyl; phenyl; methylphenyl; or (methyl)halophenyl, Ru represents oxopiperidinyl; -NH2; or -OH, and halo and halogen are each independently F, Cl, Br or I. (5) The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3) or (4), wherein the compound is one selected from the group consisting of the following compounds. 1) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide 2) (S)-N-(5-amino-3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 3) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-(dimethylamino)-iH-indol-7-yl)acetamide 4) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-methoxy-iH-indol-7-yl)acetamide 5) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-6-(dimethylamino)-iH-inden-7-yl)-2-(3-((2-((2,2,2-trifluoroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 6) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-6-methoxy-iH-indol-7-yl)-2-(3-((2-((2,2,2- trifluoroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 7) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7- yl)acetamide 8) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-fluoropyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 9) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide io) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide n) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-ethylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 12) (S)-N-(3-(5-cyclopropyl-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 13) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)-iH-indol-7-yl)acetamide 14) (S)-2-(3-((3-(cyclopropylamino)-i,2,4-triazin-5-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)-iH-indol-7-yl)acetamide 15) (S)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)pyrrolidin-i-yl)acetamide 16) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 17) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(5-methyl-2-((5-methyl-i-(2-morpholinoethyl)-iH-pyrazol-3- yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)acetamide 18) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyri din-4-yloxy)pyrrolidin-i-yl)acetamide 19) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 20) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-oxoacetamide 21) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-N-methyl-2-(3-(pyrimidin-4-yloxy)pyrrolidin-i-yl)acetamide 22) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(pyrrolidin-i-yl)propanamide 23) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-(pyridin-4-yloxy)pyrrolidin-i-yl)propanamide 24) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-methyl-2-(pyrrolidin-i-yl)propanamide 25) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-methyl-2-(3-(pyri din-4 -yloxy)pyrrolidin-i-yl)propanamide 26) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-hydroxyazetidin-i-yl)acetamide 27) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylmethoxy)azetidin-i-yl)acetamide 28) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyri din-4-yloxy)azetidin-i-yl)acetamide 29) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)azetidin-i-yl)acetamide 30) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)azetidin-i-yl)acetamide 31) methyl 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3- carboxylate 32) 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3-carboxylic acid 33) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxamide 34) 2-(5,6-dihydro-[4,4'-bipyridin]-i(2H)-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 35) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(i-methyl-iH-pyrazol-4-yl)-5,6-dihydropyridin-i(2H)-yl)acetamide 36) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(4-methylpiperazin-i-yl)piperidin-i-yl)acetamide 37) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-morpholinopiperi din-i-yl)acetamide 38) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyridin-3-yloxy)piperidin-i-yl)acetamide 39) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyridin-2-yloxy)piperidin-i-yl)acetamide 40) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(4-(pyri din-4-yloxy)piperidin-i-yl)acetamide 41) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(4-(pyrimidin-2-yloxy)piperidin-i-yl)acetamide 42) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(4-((4,6-dimethylpyrimidin-2-yl)oxy)piperidin-i-yl)acetamide 43) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperidin-4-yl)oxy)isoxazole-5-carboxamide 44) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperi din-3-yl)oxy)isoxazole-5-carboxamide 45) 2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 46) (R)-2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 47) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-ylamino)pyrrolidin-i-yl)acetamide 48) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-ylamino)pyrrolidin-i-yl)acetamide 49) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylamino)pyrrolidin-i-yl)acetamide 50) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-((3R,4S)-3-fluoro-4-hydroxypyrrolidin-i-yl)acetamide 51) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3R,4R)-3-fluoro-4-(pyri din-4 -yloxy)pyrrolidin-i-yl)acetamide 52) 2-((3R,4S)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 53) 2-((3R,4R)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 54) 2-((38,4R)-3-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 55) methyl (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH- indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylate 56) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylic acid 57) 2-((28,4S)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-2-(hydroxymethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 58) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxamide 59) 2-((28,4S)-2-(aminomethyl)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 60) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 61) (S)-2-(4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 62) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yl)acetamide 63) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrrolidin-i-yl)acetamide 64) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 65) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-methylpiperazine-i-carbonyl)pyrroli din-1-yl)acetamide 66) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yl)acetamide 67) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrrolidin-i-yl)acetamide 68) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 69) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(i,2,3,6-tetrahydropyridine-i-carbonyl)pyrrolidin-i-yl)acetamide 70) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 71) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 72) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 73) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 74) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 75) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)pyrrolidin-i-yl)acetamide 76) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)- iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 77) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 78) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4 -yloxy)pyrrolidin-i-yl)acetamide 79) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(pyrazin-2-yloxy)pyrrolidin-i-yl)acetamide 80) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-fluorophenoxy)pyrrolidin-i-yl)acetamide 81) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(3-fluorophenoxy)pyrrolidin-i-yl)acetamide 82) (S)-2-(3-(4-chlorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 83) (8)-2-(3-(2,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 84) (8)-2-(3-(3,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 85) (S)-2-(3-(2-chloro-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 86) (8)-2-(3-(3,5-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 87) (S)-2-(3-(3-amino-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 88) (S)-2-(3-(3-(diethylamino)phenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 89) (S)-2-(3-(3-aminophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 90) (S)-2-(3-((2-aminopyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5- dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 91) (S)-2-(3-((2-chloropyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 92) (S)-2-(3-((6-aminopyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 93) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 94) (S)-2-(3-((6-chloro-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 95) (S)-2-(3-((2-amino-6-methylpyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 96) (S)-2-(3-((5-amino-2-chloropyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 97) (S)-2-(3-((5-bromo-2-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 98) (S)-2-(3-((2-amino-6-(5-chloro-2-fluorophenyl)pyrimi din-4 - yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 99) (S)-2-(3-((2-amino-6-(trifluoromethyl)pyrirnidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 100) (S)-2-(3-([i,i'-biphenyl]-4-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl- iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 101) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-(2-phenylpropan-2-yl)phenoxy)pyrrolidin-i-yl)acetamide 102) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-pentylpyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 103) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(4-((4-methylpiperazin-i-yl)methyl)phenoxy)pyrrolidin-i-yl)acetamide 104) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-5-yl)oxy)pyrroli din-1-yl)acetamide 105) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 106) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)benzo[b]thiophene-2-carboxylate 107) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxylate 108) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxylic acid 109) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxamide no) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N-methylthiophene-2-carboxamide in) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)thiophene-2-carboxamide 112) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-methylisoxazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 113) (S)-2-(3-(benzo[d]isoxazol-3-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 114) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(isothiazol-3-yloxy)pyrrolidin-i-yl)acetamide 115) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-methylthiophen-3-yl)oxy)pyrrolidin-i-yl)acetamide 116) (S)-2-(3-((iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7- yl)acetamide 117) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-5-(trifluoromethyl)-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 118) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-(isoxazol-3-yloxy)pyrrolidin-i-yl)acetamide 119) (S)-2-(3-((5-amino-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 120) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3- yl)oxy)-iH-pyrrole-2-carboxylate 121) ethyl (8)-5-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)isoxazole-4-carboxylate 122) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)isoxazole-5-carboxamide 123) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N-methylisoxazole-5-carboxamide 124) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)isoxazole-5-carboxamide 125) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N,N-dimethylisoxazole-5-carboxamide 126) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-5-carboxamide 127) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-4-carboxamide 128) (8)-2-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)pyrimidine-4-carboxylic acid 129) (8)-2-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)pyrimidine-4-carboxamide 130) (8)-2-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N-methylpyrimidine-4-carboxamide 131) (8)-2-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-N,N-dimethylpyrimidine-4-carboxamide 132) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)pyrazine-2-carboxamide 133) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl) oxy)-N-methylpyrazine- 2 -carboxamide 134) (S)-2-(3-((4-amino-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 135) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 136) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 137) (S)-2-(3-((4-(cyclopropylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N- (3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)acetamide 138) (8)-2-(3-((4,6-diamino-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 139) (S)-2-(3-((4-amino-6-(pyrrolidin-i-yl)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 140) (S)-2-(3-((6-aminopyrirnidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 141) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(methylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 142) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 143) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrimi din-4-yl)oxy)pyrroli din-i-yl)acetamide 144) (S)-2-(3-((6-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 145) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 146) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((3-hydroxypropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 147) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-rnethoxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 148) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((3-(dimethylamino)propyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 149) (S)-2-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 150) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(phenethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 151) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 152) (S)-2-(3-((6-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 153) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(dimethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 154) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(methyl)amino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 155) (S)-2-(3-((6-(diethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 156) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(propyl)amino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 157) (S)-2-(3-((6-(butyl(ethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 158) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(pyrrolidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 159) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((3S)-3-((6-(3-hydroxypyrrolidin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 160) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-((6-((R)-3-hydroxypyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 161) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((S)-3-((6-((S)-3-hydroxypyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 162) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(piperidin-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 163) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-hydroxypiperi din-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 164) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-morpholinopyrimi din-4-yl)oxy)pyrroli din-1-yl)acetamide 165) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 166) (S)-2-(3-((2-amino-6-(methylamino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 167) (S)-2-(3-((2-amino-6-(pyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrroli din-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 168) (S)-2-(3-((4-aminopyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 169) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 170) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 171) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 172) (S)-2-(3-((4-(diethylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 173) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(pyrrolidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 174) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(piperidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 175) (S)-2-(3-((4-(cyclopropylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 176) (S)-2-(3-((4-amino-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 177) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(methylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 178) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 179) (S)-2-(3-((4-(cyclopropylamino)-5-fluoropyrimidin-2-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 180) (S)-2-(3-((4-(cyclohexylamino)-5-fluoropyrimidin-2-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 181) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(dirnethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 182) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 183) (S)-2-(3-((4-(diethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 184) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(rnethyl(phenyl)amino)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 185) (S)-2-(3-((4-(benzyl(methyl)amino)-5-fluoropyriniidin-2- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 186) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(pyrrolidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 187) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(piperidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 188) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-morpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 189) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-thiomorpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 190) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(4-methylpiperazin-i-yl)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 191) (S)-2-(3-((4-(cyclopropylamino)-5-methylpyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 192) (S)-2-(3-((2-aminopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 193) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylthio)pyrimidin-4-yl)oxy)pyrroli din-1-yl)acetamide 194) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-methoxypyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 195) (S)-2-(3-((2-(benzyloxy)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 196) (S)-2-(3-((2-acetamidopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 197) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 198) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2,2,2-trifluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 199) (8)-2-(3-((2-((2,2-difluoropropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 200) (8)-2-(3-((2-((2,2-difluoroethyl)amino)pyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 201) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-2-((3S)-3-((2-((i,i,i-trifluoropropan-2-yl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 202) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-fluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 203) (S)-N-(3-(2-((i,5-dirnethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(ethylamino)pyrimidin-4-yl)oxy)pyrroli din-1-yl)acetamide 204) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(propylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 205) (S)-2-(3-((2-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 206) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((3-hydroxypropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 207) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 208) (S)-2-(3-((2-(cyclobutylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 209) (S)-2-(3-((2-(cyclopentylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 210) (S)-2-(3-((2-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 211) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(isopropylamino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 212) 2-((3S)-3-((2-(sec-butylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 213) (S)-2-(3-((2-((cyclopropylmethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 214) (S)-2-(3-((2-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 215) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 216) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-rnethoxyethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 217) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-(dimethylarnino)ethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 218) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((3-(dimethylamino)propyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 219) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(methoxyamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 220) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 221) (S)-2-(3-((2-(benzyl(methyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 222) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyrrolidin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 223) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(piperidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide. 224) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 225) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 226) (S)-2-(3-((2-amino-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 227) (S)-2-(3-((2-(cyclopropylamino)-5-fluoropyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 228) (S)-2-(3-((2-(cyclohexylamino)-5-fluoropyrirnidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 229) (S)-2-(3-((2-((cyclopropylmethyl)amino)-5-fluoropyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 230) (S)-2-(3-((2-(benzylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 231) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 232) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 233) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 234) (S)-2-(3-((2-(cyclopropylamino)-6-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 235) (S)-2-(3-((2-(cyclopropylamino)-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 236) (S)-2-(3-((2-(cyclopropylamino)-6-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 237) (S)-2-(3-((2-(cyclopropylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 238) (S)-2-(3-((2-(cyclopropylamino)-6-methoxypyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 239) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-(dimethylamino)ethyl)amino)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 240) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 241) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 242) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 243) (S)-2-(3-((6-(cyclopropylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 244) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 245) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 246) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 247) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-(dimethylamino)ethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 248) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-phenylpyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 249) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(i-methyl-iH-pyrazol-4-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 250) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((6-(4,4-dimethylcyclohex-i-en-i-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 251) (8)-2-(3-((6-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 252) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-(4,4-dimethylcyclohex-i-en-i-yl)pyrimi din-2-yl)oxy)pyrrolidin-i-yl)acetamide 253) (8)-2-(3-((4-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 254) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((4-phenylpyrimidin-2-yl)oxy)pyrroli din-1-yl)acetamide 255) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyridin-3-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 256) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyridin-4-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 257) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-phenylpyrimidin-5-yl)oxy)pyrroli din-1-yl)acetamide 258) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-3-yl)pyrimidin-5-yl)oxy)pyrroli din-1-yl)acetamide 259) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-4-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 260) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 261) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-fluoroisoindoline-i, 3-dione 262) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 263) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindoline-i,3-dione 264) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-nitroisoindoline-i,3-dione 265) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 266) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 267) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindolin-i-one 268) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-nitroisoindolin-i-one 269) 6-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 270) 5-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 271) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-nitroisoindolin-i-one 272) 4-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 273) 7-chloro-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 274) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitroisoindolin-i-one 275) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodoisoindolin-i-one 276) 7-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 277) 7-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 278) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-iodoisoindolin-i-one 279) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-methoxyisoindolin-i-one 280) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4,6-dimethoxyisoindolin-i-one 281) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindolin-i-one 282) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 283) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 284) 6-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 285) 3-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 286) 4-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 287) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-3-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyri din-7-one 288) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 289) 7-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 290) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 291) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-5-yl)cyclopropanecarboxamide 292) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)cyclohexanecarboxamide 293) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzamide 294) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzamide 295) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohexanecarboxamide 296) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)morpholine-4-carboxamide 297) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 298) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)nicotinamide 299) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-4-carboxamide 300) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopropanecarboxamide 301) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isonicotinamide 302) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyridazine-4-carboxamide 303) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohexane-i-carboxamide 304) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(3-hydroxyphenyl)acetamide 305) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-phenylacetamide 306) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-4-carboxamide 307) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-3-carboxamide 308) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 309) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohex-3-ene-i-carboxamide 310) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopent-3-ene-i-carboxamide 311) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylcyclopent-3-ene-i-carboxamide 312) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cycloheptanecarboxamide 313) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-oxoimidazolidine-i-carboxamide 314) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2,3-dihydro-iH-indene-2-carboxamide 315) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 316) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 317) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 318) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 319) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)piperidine-3-carboxamide 320) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-oxocyclohexane-i-carboxamide 321) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-4-carboxamide 322) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methyloxazole-4-carboxamide 323) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-5-carboxamide 324) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isoxazole-3-carboxamide 325) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-3-carboxamide 326) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydrofuran-3-carboxamide 327) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-3-carboxamide 328) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methyltetrahydro-2H-pyran-4-carboxamide 329) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylcyclohexane-i-carboxamide 330) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohex-3-ene-i-carboxamide 331) (2R,4S)-4-amino-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-2-carboxamide 332) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylpiperidine-3-carboxamide 333) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpyrrolidine-3-carboxamide 334) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylnicotinamide 335) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(dimethylamino)acetamide 336) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopentanecarboxamide 337) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-4-carboxamide 338) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)furan-3-carboxamide 339) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-6-hydroxypyrimidine-4-carboxamide 340) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzenesulfonamide 341) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzenesulfonamide 342) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)methanesulfonamide 343) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylbenzenesulfonamide 344) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)propane-2-sulfonamide 345) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-fluoro-3-methylbenzenesulfonamide 346) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(phenylamino)isoindolin-i-one 347) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-morpholinoisoindolin-i-one 348) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(4-methylpiperazin-i-yl)isoindolin-i-one 349) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)isoindolin-i-one 350) 7-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 351) 7-((cyclopropylmethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 352) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-morpholinoisoindolin-i-one 353) 4-((cyclopropylmethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 354) 4-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 355) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(phenylethynyl)isoindolin-i-one 356) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(phenylethynyl)isoindolin-i-one 357) 4-((4-aminophenyl)ethynyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 358) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 359) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 360) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 361) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methylacrylamide 362) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-4-(3-oxobut-i-en-i-yl)isoindolin-i-one 363) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-methylacrylamide 364) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethylacrylamide 365) (E)-N-cyclopropyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 366) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylohydrazide 367) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylic acid 368) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-diethylacrylamide 369) (E)-N,N-dibutyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 370) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-isopropylacrylamide 371) (E)-N-(tert-butyl)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 372) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-hydroxyethyl) acrylamide 373) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-propylacrylamide 374) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-methoxyethyl)acrylamide 375) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-hydroxyprop-i-en-i-yl)isoindolin-i-one 376) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethyl-2-methylacrylamide 377) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-phenylisoindolin-i-one 378) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-phenylisoindolin-i-one 379) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-phenylisoindolin-i-one 380) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(pyridin-4-yl)isoindolin-i-one 381) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-6-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 382) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-phenylisoindolin-i-one 383) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)isoindolin-i-one 384) 7-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 385) 7-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 386) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(iH-pyrazol-4-yl)isoindolin-i-one 387) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)isoindolin-i-one 388) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)isoindolin-i-one 389) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-pyrazol-4-yl)isoindolin-i-one 390) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrazol-4-yl)isoindolin-i-one 391) 4-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 392) 4-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 393) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(furan-3-yl)isoindolin-i-one 394) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 395) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(trifluoromethoxy)phenyl)isoindolin-i-one 396) 4-(4-arninophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 397) tert-butyl 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6- dihydropyridine-i(2H)-carboxylate 398) / er / -butyl (4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)phenyl)carbamate 399) 4-(2-aminopyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 400) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-fluoropyridin-4-yl)isoindolin-i-one 401) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-hydroxypyridin-3-yl)isoindolin-i-one 402) 4-(2-chloropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 403) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoro-2-methoxypyridin-4-yl)isoindolin-i-one 404) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-4-yl)isoindolin-i-one 405) 4-(6-chloropyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 406) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-methoxypyridin-3-yl)isoindolin-i-one 407) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-fluoro-5-methylpyridin-3-yl)isoindolin-i-one 408) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyri din-4-yl)isoindolin-i-one 409) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(pyrrolidin-i-ylsulfonyl)phenyl)isoindolin-i-one 410) (£)-2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-fluorostyryl)isoindolin-i-one 411) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrolo[2,3-b]pyridin-4-yl)isoindolin-i-one 412) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-oxopiperidine-i-carbonyl)phenyl)isoindolin-i-one 413) 4-(3,6-dihydro-2H-thiopyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 414) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyrimidin-5-yl)isoindolin-i-one 415) 4-(i-(cyclopropylmethyl)-iH-pyrazol-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 416) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(2-morpholinoethyl)-iH-pyrazol-4-yl)isoindolin-i-one 417) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-5-yl)isoindolin-i-one 418) 4-(2-aminopyrimidin-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 419) 4-(5-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 420) 4-(6-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 421) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-4-yl)isoindolin-i-one 422) 4-(2-aminopyrimi din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 423) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)pyridin-2-yl)isoindolin-i-one 424) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyrimidin-5-yl)isoindolin-i-one 425) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-morpholinopyridin-3-yl)isoindolin-i-one 426) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)phenyl)isoindolin-i-one 427) 4-(2,6-difluoropyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 428) 4-(3,5-difluoropyridin-4-yl)-2-(3-(2-((i, 5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 429) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)isoindolin-i-one 430) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-[4,5'-biisoindolin]-i-one 431) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-3-yl)isoindolin-i-one 432) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzonitrile 433) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-fluorobenzonitrile 434) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(trifluoromethyl)phenyl)isoindolin-i-one 435) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-3-yl)isoindolin-i-one 436) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(dimethylamino)phenyl)isoindolin-i-one 437) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)phenyl)isoindolin-i-one 438) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxyphenyl)isoindolin-i-one 439) 4-([i,i'-biphenyl]-2-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 440) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(o-tolyl)isoindolin-i-one 441) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxyphenyl)isoindolin-i-one 442) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrol-2-yl)isoindolin-i-one 443) / er / -butyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-iH-pyrrole-i-carboxylate 444) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3,5-dimethylisoxazol-4-yl)isoindolin-i-one 445) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-4-yl)isoindolin-i-one 446) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxypyri din-4-yl)isoindolin-i-one 447) 4-(3-aminopyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 448) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(isoquinolin-7-yl)isoindolin-i-one 449) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-5-yl)isoindolin-i-one 450) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-6-yl)isoindolin-i-one 451) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylthiophen-2-yl)isoindolin-i-one 452) 4-(2,3-dihydro-iH-inden-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 453) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-methylthiophen-3-yl)isoindolin-i-one 454) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methylpyridin-4-yl)isoindolin-i-one 455) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-methylpyri din-4-yl)isoindolin-i-one 456) 4-(6-aminopyrimidin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 457) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-indazol-4-yl)isoindolin-i-one 458) 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4 -yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoic acid 460) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(hydroxymethyl)phenyl)isoindolin-i-one 461) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(thiophen-3-yl)isoindolin-i-one 462) 4-(2-aminophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 463) methyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoate 464) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 465) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(methylsulfonyl)-i,2,3,6-tetrahydropyridin-4- yl)isoindolin-i-one 466) 4-(i-acetyl-i,2,3,6-tetrahydropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 467) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6-dihydropyridine-i(2H)-carboxamide 468) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,i-dioxido-3,6-dihydro-2H-thiopyran-4-yl)isoindolin-i-one 469) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 470) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 471) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-(hydroxymethyl)pyri din-4-yl)isoindolin-i-one 472) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)pyridin-4-yl)isoindolin-i-one 473) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 474) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 475) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyridin-4-yl)isoindolin-i-one 476) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 477) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylpyridin-3-yl)isoindolin-i-one 478) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)isoindolin-i-one 479) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)isoindolin-i-one 480) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(pyridin-4-yl)isoindolin-i-one 481) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methoxypyridin-4-yl)isoindolin-i-one 482) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 483) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyridin-4-yl)-7-fluoroisoindolin-i-one 484) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-fluoropyridin-3-yl)isoindolin-i-one 485) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-fluoropyri din-4-yl)isoindolin-i-one 486) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-methylpyridin-3-yl)isoindolin-i-one 487) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(3-methylpyri din-4 -yl)isoindolin-i-one 488) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)-7-fluoroisoindolin-i-one 489) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitro-4-(pyridin-4-yl)isoindolin-i-one 490) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)-4-(pyridin-4-yl)isoindolin-i-one 491) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(methylamino)-4-(pyri din-4-yl)isoindolin-i-one 492) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodo-4-phenylisoindolin-i-one 493) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-phenyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 494) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 495) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 496) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 497) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(pyri din-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7- one 498) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(i,2,3,6-tetrahydropyri din-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 499) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(i,2,3,6-tetrahydropyri din-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 500) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 501) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 502) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 503) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 504) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 505) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-(5-methylpyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 506) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)- iH-indol-7-yl)-4-(3-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one (5a) The present invention provides a compound above, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. (6) The present invention provides a pharmaceutical composition, comprising the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3), (4), (5) or (5a) as an active ingredient. (7) The pharmaceutical composition according to (6) is used for preventing or treating GCN2 activation-related diseases. (8) The pharmaceutical composition according to (6), the composition further comprises one or more therapeutic agent selected from the group consisting of chemotherapy agent, radiotherapy agent, immunotherapy agent and tumor microenvironment modulating agent. (9) The present invention provides a method for preventing or treating GCN2 activation-related diseases, comprising administering a therapeutically effective amount of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3), (4), (5) or (5a); or the pharmaceutical composition according to (6), (7) or (8) into a subject. (10) The method according to (9), wherein the GCN2 activation-related diseases comprise a cancer, a neurodegenerative disease, a chronic infection and a metabolic disease. (11) The method according to (10), wherein the cancer is one more selected from the group consisting of thyroid cancer, melanoma, prostate cancer, endometrial cancer, lung cancer, head and neck cancer, pancreatic cancer, glioma, stomach cancer, urothelial cancer, skin cancer, breast cancer, colorectal cancer, renal cancer, fibrosarcoma, bone sarcoma, connective tissue sarcoma, giant cell carcinoma, squamous cell carcinoma, leukemia, skin cancer, soft tissue cancer, liver cancer, adenocarcinoma, hepatocellular carcinoma, multiple myeloma, myelodysplastic syndrome, myeloproliferative neoplasm, malignant glioma, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, Burkitt’s lymphoma, chronic lymphocytic leukemia, chronic myeloid leukemia, hairy cell leukemia, plasmacytoma, lymphoplasmacytic lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, large granular lymphocytic leukemia, B-cell prolymphocytic leukemia, T-cell prolymphocytic leukemia, small cell lung cancer and pediatric neuroblastoma. (12) The present invention provides a method for inhibiting GCN2 activity, comprising administering a therapeutically effective amount of the compound, the tautomer thereof, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3), (4), (5) or (5a); or the pharmaceutical composition according to (6), (7) or (8) into a subject. (13) The present invention provides a use of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3), (4), (5) or (5a) for preventing or treating GCN2 activation-related diseases. (14) The present invention provides a use of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to (1), (2), (3), (4), (5) or (5a) in the manufacture of a medicament for preventing or treating GCN2 activation-related diseases. Matters mentioned in the use, composition and therapeutic method of the present invention are equally applied, if not contradictory to each other. MODE FOR INVENTION Hereinafter, preferred Examples will be suggested for better understanding of the present invention. However, the following Examples are provided only for the purpose of illustrating the present invention, and thus the present invention is not limited thereto. All chemical reagents were commercially available. Flash column chromatography means silica gel chromatography unless specified otherwise, which was performed on Teledyne Combiflash-RF2OO System. 1H NMR spectra (8, ppm) are recorded on 400 MHz or 600 MHz instrument. Mass spectroscopy data (ESI, m / z) for a positive ionization method were measured from Agilent technologies single quadrupole G6120B equipped with Agilent technologies 1260 Infinity system. Preparative HPLC (Prep HPLC) was performed on Agilent technologies G1361A. Hereinafter, the following Examples may be appropriately changed and modified by those skilled in the art within the scope of the present invention. Preparing Example: Synthesis of 3-(2-((1,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-amine and 2-chloro-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am ino)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide [General Method A] Fe, NH4CI THF, H2O, 80 °C Step g Intermediate 001 THF, 50 °C Step h Intermediate 002 [Step a] Preparation of 7-nitro-i-tosyl-iH-indole. In an oven-dried 3 L round bottom flask containing a magnetic stirring bar, a mixture of 7-nitro-iH-indole (CAS Number: 6960-42-5, 81 g, 500 mmol) and tosyl chloride (TsCl, 114 g, 600 mmol) in DCM (660 mL) was cooled to o°C with stirring. To the mixture was added a solution of NaOH (200 g, 5,000 mmol) in water (330 mL) slowly. The reaction was allowed to warm up to room temperature and stirred for 2 h. The reaction mixture was poured into 1 L of water, extracted with DCM (3X2 L), washed with 10 % K2CO3 aqueous solution (400 mL) and 1 N HC1 aqueous solution (400 mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure. Then, the crude product was triturated with MeOH (300 mL), filtered, and dried in vacuo to give the desired product as a white solid (yield, 95%). MS (ESI, m / z): 317.0 [M+H]+ iH NMR (400 MHz, DMSO) 8 8.05 (d, J = 3.7 Hz, 1H), 7.97 (dd, J = 7.8, 0.9 Hz, 1H), 7.83 (dt, J = 7.'9, 1.9 Hz, 1H), 7.80 - 7.76 (m, 2H), 7.48 (d, J = 7.8 Hz, 1H), 7.44 (d, J = 8.3 Hz, 2H), 7.08 (d, J = 3.7 Hz, 1H), 2.37 (s, 3H). [Step b] Preparation of 3-bromo-7-nitro-i-tosyl-iH-indole. In an oven-dried 5 L round bottom flask containing a magnetic stirring bar, to a mixture of 7-nitro-i-tosyl-iH-indole (145.5 g, 460 mmol) in DMF (500 mL) was added a solution of N-bromosuccinmide (NBS, 98.0 g) in DMF (300 mL) slowly. The reaction mixture was heated to 6o°C for 3 h. After cooling to room temperature, the reaction mixture was poured into 3 L of water with stirring to give the yellow precipitate. The precipitate was filtered and dissolved again in DCM (10 L) to wash with 1 N NaOH aqueous solution (4 L) and water (2 L). Then, the product was dried over anhydrous Na2SO4, concentrated under reduced pressure, triturated with MeOH (250 mL), filtered, and dried in vacuo to give the desired product as a white solid (yield, 91%). MS (ESI, m / z): 394.9 [M+H]+ 1H NMR (400 MHz, dmso) 8 8.47 (s, 1H), 7.97 (dd, J = 7.9, 0.9 Hz, 1H), 7.89 -7.84 (m, 3H), 7.59 (t, J = 7.9 Hz, 1H), 7.48 (dd, J = 8.6, 0.6 Hz, 2H), 2.40 (s, 3H). [Step c] Preparation of 7-nitro-3-(4,4,5,5-tetramethyl-i,3,2-dioxaborolan-2-yl)-i-tosyl-iH-indole. In an oven-dried 5 L round bottom flask containing a magnetic stirring bar under N2 atmosphere, a mixture of 3-bromo-7-nitro-i-tosyl-iH-indole (130 g, 330 mmol), bis(pinacolato)diboron (B2pin2, 117 g, 462 mmol), Pd(dppf)Cl2 / CH2Cl2 (27 g, 33 mmol), and KOAc(65 g, 660 mmol) in dimethoxyethane (DME, 2 L) was heated to 85°C for 12 h. After cooling to room temperature, the reaction mixture was filtered with the Celite® and concentrated under reduced pressure. The residue was then triturated with MeOH (3 X 400 mL), filtered, and dried in vacuo to give the desired product as a light gray solid (yield, 68%). MS (ESI, m / z): 443.1 [M+H]+ 1H NMR (400 MHz, dmso) 8 8.32 (s, 1H), 8.18 (dd, J = 7.9, 1.1 Hz, 1H), 8.01 -7.96 (m, 2H), 7.86 (dd, J = 7.9, 1.0 Hz, 1H), 7.54 (d, J = 7.9 Hz, 1H), 7.52 - 7.47 (m, 2H), 2.42 (s, 3H), 1.34 (s, 12H). [Step d] Preparation of 3-(2-chloro-5-methylpyrimidin-4-yl)-7-nitro-i-tosyl-iH-indole. In an oven-dried 2 L round bottom flask containing a magnetic stirring, a mixture of 7-nitro-3-(4,4,5,5-tetramethyl-i,3,2-dioxaborolan-2-yl)-i-tosyl-iH-indole (63 g, 142 mmol), Pd(PPh3)4 (16 g, 14 mmol), 2,4-dichloro-5-methylpyrimidine(3O g, 185 mmol), and K2CO3 (39 g, 284 mmol) in 1,4-dioxane (700 mL) and water (260 mL) was heated to 8o°C for 12 h. After cooling to room temperature, the reaction mixture was poured into water (500 mL), extracted with DCM (3 X 1.5 L), washed with brine, dried over anhydrous Na2SO4, and concentrated under reduce pressure. Then, the residue was triturated with MeOH (250 mL), filtered, and dried in vacuo to give the desired product as a white solid (yield, 91%). MS (ESI, m / z): 443.0 [M+H]+ iH NMR (400 MHz, dmso) 8 8.78 (t, J = 6.7 Hz, 1H), 8.63 (s, 1H), 8.39 (dt, J = 19.8, 9.9 Hz, 1H), 7.97 (dd, J = 7.9, 0.9 Hz, 1H), 7.92 (dd, J = 8.7, 2.0 Hz, 2H), 7.61 (t, J = 8.0 Hz, 1H), 7.52 - 7.46 (m, 2H), 2.44 (s, 3H), 2.40 (s, 3H). [Step e] Preparation of 3-(2-chloro-5-methylpyrimidin-4-yl)-7-nitro-iH-indole. To a solution of 3-(2-chloro-5-methylpyrimidin-4-yl)-7-nitro-i-tosyl-iH-indole (47 g, 107 mmol) in MeOH (1 L) was added K2CO3 (30 g, 214 mmol). The reaction was heated to 5O°C for 6 h and cooled to room temperature. Then, the reaction mixture was poured into water (400 mL) with stirring to give the precipitate. The precipitate was filtered, washed with MeOH, and dried in vacuo to give the desired product as a brown solid (yield, 98%). MS (ESI, m / z): 289.0 [M+H]+ 1H NMR (400 MHz, dmso) 8 12.65 (s, 1H), 8.89 (dd, J = 8.0,1.0 Hz, 1H), 8.62 (d, J = 0.7 Hz, 1H), 8.24 (dd, J = 8.1,1.0 Hz, 1H), 8.19 (d, J = 3.9 Hz, 1H), 7.46 (t, J = 8.0 Hz, 1H), 2.51 (t, J = 0.9 Hz, 3H). [Step f] Preparation of N-(i,5-dimethyl-iH-pyrazol-3-yl)-5-methyl-4-(7-nitro-iH-indol-3-yl)pyrimidin-2-amine. A mixture of 3-(2-chloro-5-methylpyrimidin-4-yl)-7-nitro-iH-indole (5.80 g, 20 mmol), i,5-dimethyl-iH-pyrazol-3-amine (2.80 g, 25 mmol), and cone. HC1 (1.67 mL, 20 mmol) in 2-methoxyethanol (40 mL) was heated to 13O°C for 72 h. After cooling to room temperature, the reaction mixture was mixed with 10 mL of isopropyl alcohol (IPA) to give the precipitate. The precipitate was filtered, washed with IPA (100 mL), and dried in vacuo to give the desired product as a yellowish solid (yield, 83%). MS (ESI, m / z): 364.1 [M+H]+ 1H NMR (400 MHz, dmso) 8 12.83 (s, 1H), 11.21 (s, 1H), 9.27 (d, J = 7.8 Hz, 1H), 8.37 (s, 1H), 8.34 (d, J = 3.1 Hz, 1H), 8.28 - 8.24 (m, 1H), 7.46 (t, J = 8.0 Hz, 1H), 6.12 (s, 1H), 3.77 (s, 3H), 2.50 (s, 3H), 2.29 (s, 3H). [Step g] Synthesis of 3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-amine (Intermediate 001). A mixture of N-(1,5-dimethyl-iH-pyrazol-3-yl)-5-methyl-4-(7-nitro-iH-indol-3-yl)pyrimidin-2-amine (15 g, 40 mmol), Fe (powder form, 11 g, 200 mmol), and NH4C1 (21 g, 400 mmol) in THF (560 mL) and water (260 mL) was heated to reflux for 8 h. After cooling to room temperature, the reaction mixture was filtered to remove the black slurry. Then, the filtrate concentrated under reduced pressure and solidified from the mixed solvent of MeOH (250 mL) and DCM (750 mL). The precipitate was filtered, washed with MeOH (100 mL), and dried in vacuo to give the desired product as a white solid (yield, 93%). MS (ESI, m / z): 334.1 [M+H]+ 1H NMR (400 MHz, dmso) 8 11.25 (s, 1H), 9.10 (s, 1H), 8.17 (s, 1H), 7.88 (d, J = 2.6 Hz, 1H), 7.79 (d, J = 8.2 Hz, 1H), 6.81 (t, J = 7.7 Hz, 1H), 6.46 (s, 1H), 6.41 (d, J = 7.3 Hz, 1H), 5.11 (s, 2H), 3.62 (s, 3H), 2.33 (s, 3H), 2.19 (s, 3H). [Step h] Preparation of 2-chloro-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide (Intermediate 002). A mixture of 3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-amine (10 g, 30 mmol) in THF (300 mL) was heated to 6o°C for 2 h to be dissolved clearly. The mixture was cooled to room temperature and 2-chloroacetyl chloride (7.6 mL, 100 mmol) was added dropwise. The reaction was heated to reflux for 12 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure to remove solvent and triturated with MeOH (100 mL) to give the precipitate. The precipitate was filtered, washed with MeOH (100 mL), and dried in vacuo to give the desired product as a light green solid (yield, 70%). MS (ESI, m / z): 410.1 [M+H]+ 1H NMR (600 MHz, cd3od) 8 8.70 (s, 1H), 8.30 (s, 1H), 8.18 (s, 1H), 7.35 - 7.16 (m, 2H), 5.99 (s, 1H), 4.35 (s, 2H), 3.80 (s, 3H), 2.53 (s, 3H), 2.32 (s, 3H). Example 1: Synthesis of(S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-m ethylpyrim idin-4-yl)-6-fluoro-lH-indol-7-yl)acetam ide [General Method B] Step b, c, d, f, h of General Method A Intermediate 002' h5n—<] TEA, DMF, 50 °C Step c1 Example 1 [Step a'] A solution of 2-chloro-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide (Intermediate 002'; 345 mg, 0.8 mmol) and (R)-pyrrolidin-3-ol (104 mg, 1.2 mmol) in DMF (3 mL) was treated with triethylamine(o.22 mL, 1.6 mmol) and stirred for 2 h at 5O°C. The mixture was concentrated in vacuo and purified by column chromatography (0-30% MeOH in DCM) to give (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide(28o mg, 72%). MS (ESI, m / z): 479.2 [M+H]+ [Step b'] A solution of (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide (191 mg, 0.4 mmol), 2-chloropyrimidin-4-ol (65 mg, 0.5 mmol) and triphenylphosphine (157 mg, 0.6 mmol) in THF (3 mL) was treated with diisopropyl azodicarboxylate (0.157 mL, 0.8 mmol) and stirred for 2 h. The mixture was concentrated in vacuo and purified by column chromatography (0-30% MeOH in DCM) to give (S)-2-(3-((2-chloropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide (170 mg, 71%). MS (ESI, m / z): 591.2 [M+H]+ [Step c'] A solution of (S)-2-(3-((2-chloropyrimidin-4-yl)oxy) pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide (118 mg, 0.2 mmol) and cyclopropylamine (20 pL, 0.3 mmol) in DMF (1 mL) was treated with triethylamine (70 pL, 0.5 mmol) and stirred for 2 h at 5O°C. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product as a white solid (60 mg, 49%). MS (ESI, m / z): 612.3 [M+H]+ 2-chloro-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide was afforded using 2-chloro-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide which was prepared by Step b, c, d, f, g and h of General method A using N-(6-fluoro-i-((2-(trimethylsilyl)ethoxy)methyl)-iH-indol-7-yl)-4-methylbenzenesulfonamide instead of 7-nitro-i-tosyl-iH-indole. Example 2: Synthesis of (S)-N-(5-amino-3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((2-(cyclopro pylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded using (8)-2-(3-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide which prepared by General method B using Intermediate 002'. Step a". At o°C, a solution of (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide (297 mg, 0.5 mmol) in C-H2SO4 (3 mL) was treated with HNO3 (0.1 mL) and stirred for 8h. The mixture was diluted with water(io mL), basified with sodium bicarbonate(9 g) and filtered to give (8)-2-(3-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-5-nitro-iH-indol-7-yl)acetamide (35 mg, 10%). Step b". A solution of (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-5-nitro-iH-indol-7-yl)acetamide (33 mg, 0.05 mmol) and 10% Pd / C (10 mg) in MeOH(i mL) was stirred under H2 gas for ih. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product as a white solid (16 mg, 52%). MS (ESI, m / z): 609.3 [M+H]+ Example 3: Synthesis of (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl) 0 xy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazo 1-3-yl) amino)-5-m ethylpyrim idin-4-yl)-6-(dim ethylam ino)-lH-indol-7-yl)acetam ide The title product was afforded by General Method B using 2-chloro-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-6-(dimethylamino)-iH-indol-7-yl)acetamide instead of 2-chloro-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide, which was prepared by General Method A using N,N-dimethyl-7-nitro-iH-indol-6-amine instead of 7-nitro-iH-indole. MS (ESI, m / z): 637.3 [M+H]+ Example        4:        Synthesis        of       (S)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-6-m ethoxy-1H-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 3 using 6-methoxy-7-nitro-iH-indole instead of 7-nitro-iH-indole. MS (ESI, m / z): 624.3 [M+H]+ Example 5: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-6-(dim e th ylam ino)-lH-inden-7-yl)-2-(3-((2-((2,2,2-trifluoro ethyl) am ino)pyrim idin-4-yl) oxy) pyrro lidin -1-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 3 using 2,2,2-trifluoroethan-i-amine instead of cyclopropylamine. MS (ESI, m / z): 678.3 [M+H]+ Example 6: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-6-m ethoxy-lH-indol-7-yl)-2-(3-((2-((2,2,2-trifluoro ethyl) am ino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 4 using 2,2,2-trifluoroethan-i-amine instead of cyclopropylamine. MS (ESI, m / z): 666.3 [M+H]+ Example 7: Synthesis of(S)-2-(3-((6-(cyclopropylamino)pyrimidin- 4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)pyrim idin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 3 using 7-nitro-iH-indole instead of N,N-dimethyl-7-nitro-iH- indol-6-amine, 2,4-dichloropyrimidine instead of 2,4-dichloro-5-methylpyrimidine and 6-chloropyrimidin-4-ol instead of 2-chloropyrimidin-4-ol. MS (ESI, m / z): 580.3 [M+H]+ Example 8: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-fluoropyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 7 using 2,4-dichloro-5-fluoropyrimidine instead of 2,4-dichloropyrimidine and pyridin-4-ol instead of 6-chloropyrimidin-4-ol. MS (ESI, m / z): 542.2 [M+H]+ Example 9: Synthesis of (S)-N-(3-(5-chloro-2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)pyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 8 using 2,4-dichloro-5-chloropyrimidine instead of 2,4-dichloro-5-fluoropyrimidine. MS (ESI, m / z): 558.2 [M+H]+ Example 10: Synthesis of (S)-N-(3-(5-chloro-2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)pyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 7 using 2,4,5-trichloropyrimidine instead of 2,4-dichloropyrimidine and 2-chloropyrimidin instead of 6-chloropyrimidin-4-ol. MS (ESI, m / z): 614.2 [M+H]+ Example        11:        Synthesis        of (8)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) amino )-5-e th yip yrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 10 using 2,4-dichloro-5-ethylpyrimidine instead of 2,4,5-trichloropyrimidine. MS (ESI, m / z): 608.3 [M+H]+ Example 12: Synthesis of (S)-N-(3-(5-cyclopropyl-2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)pyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 10 using 2,4-dichloro-5-cyclopropylpyrimidine instead of 2,4,5-trichloropyrimidine. MS (ESI, m / z): 620.3 [M+H]+ Example        13:       Synthesis       of (S)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am ino)-5-m ethoxypyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 10 using 2,4-dichloro-5-methoxypyrimidine instead of 2,4,5-trichloropyrimidine. MS (ESI, m / z): 610.3 [M+H]+ Example 14: Synthesis of (S)-2-(3-((3-(cyclopropylamino)-l,2,4-triazin-5-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-lH-pyrazol-3-yl)am in 0)-5-m ethoxypyrim idin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 13 using 3-chloro-i,2,4-triazin-5-ol instead of 2-chloropyrimidin-4-ol. MS (ESI, m / z): 611.3 [M+H]+ Example 15: Synthesis of (S)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[l,2-b]pyrazol-2-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrim idin-4-yloxy)pyrrolidin-l-yl)acetam ide The title product was afforded by General Method A using 5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-amine instead of i,5-dimethyl-iH-pyrazol-3-amine and General Method B using pyrimidin-4-ol instead of 2-chloropyrimidin-4-ol. MS (ESI, m / z): 551.3 [M+H]+ Example        16:       Synthesis       of (S)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[l,2-b]pyrazol-2-yl)amino)-5-methylpyrimidin-4-yl)-1H-indo 1-7-yl) acetamide The title product was afforded by General Method A using 5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-amine instead of i,5-dimethyl-iH-pyrazol-3-amine and General Method B. MS (ESI, m / z): 606.3 [M+H]+ Example 17:        Synthesis        of (S)-2-(3-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(5-m ethyl-2-((5-methyl-l-(2-morpholinoethyl)-lH-pyrazol-3-yl)amino)pyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 16 using 5-methyl-i-(2-morpholinoethyl)-iH-pyrazol-3-amine instead of 5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-amine. MS (ESI, m / z): 693.4 [M+H]+ [General Method C] DIAD, PPh3, THF Step a" H2N TEA, DME, 50°C Step b" 1NHCI in MeOH Step c" DIAD, PPh3, THF Step a" 1NHCI in MeOH Step c" [Step a"] A solution of tert-butyl (R)-3-hydroxypyrrolidine-i-carboxylate (187 mg, 1 mmol), 2-chloropyrimidin-4-ol (156 mg, 1.2 mmol) (or pyridin-4-ol (114 mg, 1.2 mmol)) and triphenylphosphine (367 mg, 1.4 mmol) in THF (5 mL) was treated with diisopropyl azodicarboxylate (0.354 mL, 1.8 mmol) and stirred for 2 h. The mixture was concentrated in vacuo and purified by column chromatography (0-40% EA in Hx) to give tert-butyl (S)-3-((2-chloropyrimidin-4-yl)oxy)pyrrolidine-i-carboxylate (220 mg, 73%)- MS (ESI, m / z): 300.1 [M+H]+ (or tert-butyl (S)-3-(pyridin-4-yloxy)pyrrolidine-i-carboxylate (200 mg, 75%). MS (ESI, m / z): 265.2 [M+H]+) [Step b"] A solution of (S)-3-((2-chloropyrimidin-4-yl)oxy)pyrrolidine-i-carboxylate (450 mg, 1.5 mmol) and cyclopropylamine (200 pL, 3 mmol) in DMF (2 mL) was treated with triethylamine (420 pL, 3 mmol) and stirred for 2 h at 5O°C. Then, the mixture was concentrated in vacuo and purified by column chromatography (o-50% EA in Hx) to give tert-butyl (S)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidine-i-carboxylate (300 mg, 62%). MS (ESI, m / z): 321.2 [M+H]+ [Step c"] / erz-butyl (S)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidine-i-carboxylate (160 mg, 0.5 mmol) (or / er / -butyl (S)-3-(pyridin-4-yloxy)pyrrolidine-i-carboxylate (132 mg, 0.5 mmol)) was dissolved in 1N HC1 in MeOH(2 mL). The mixture was stirred for 2 h and separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product quantitatively. MS (ESI, m / z): 221.1 [M+H]+(or MS (ESI, m / z): 165.1 [M+H]+) Example 18: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-oxo-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide To a stirred mixture of 2-((3-(2-((1,5-dimethyl-iH-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoacetic acid (20 mg, 0.05 mmol), HATU (23 mg, 0.06 mmol), and EtsN (14 uL, 0.10 mmol) in 0.5 mL of DMF was added (S)-4-(pyrrolidin-3-yloxy)pyridine (10 mg, 0.06 mmol). The reaction mixture was heated to 5O°C for 3 h. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product as a white solid (yield, 40%). MS (ESI, m / z): 552.2 [M+H]+ Example 19: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-oxo-2-(3-(pyridin-2- yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 18 using 2-(pyrrolidin-3-yloxy)pyridine instead of (S)-4-(pyrrolidin-3-yloxy)pyridine. MS (ESI, m / z): 552.2 [M+H]+ Example       20:       Synthesis       of (S)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-oxoacetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 18 using (S)-N-cyclopropyl-4-(pyrrolidin-3-yloxy)pyrimidin-2-amine instead of (S)-4-(pyrrolidin-3-yloxy)pyridine. MS (ESI, m / z): 608.3 [M+H]+ Example 21: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-N-m ethyl-2-(3-(pyrim idin-4-yloxy)pyrrolidin-l-yl)acetam ide The title compound was afforded by General Method A using N-(iH-indol-7-yl)-N,4-dimethylbenzenesulfonamide instead of 7-nitro-iH-indole and General Method B using pyrimidin-4-ol instead of 2-chloropyrimidin-4-ol. MS (ESI, m / z): 553-3 [M+H]+ Example 22: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(pyrrolidin-l-yl)propanamide The title compound was afforded by General Method A using 2-chloropropanoyl chloride instead of 2-chloroacetyl chloride and General Method B using pyrrolidine instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 459.3 [M+H]+ Example 23: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-((S)-3-(py ridin-4-ylo xy) pyrro lidin-1-yl) propan am ide The title product was afforded by a procedure similar to that described for the synthesis of Example 22 using (S)-4-(pyrrolidin-3-yloxy)pyridine instead of pyrrolidine. MS (ESI, m / z): 551.3 [M+H]+ Example 24: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-me th yl-2-(pyrro lidin-1-yl) pro pan am ide The title product was afforded by a procedure similar to that described for the synthesis of Example 22 using 2-chloro-2-methylpropanoyl chloride instead of 2-chloropropanoyl chloride. MS (ESI, m / z): 473.3 [M+H]+ Example 25: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-m ethyl-2-(3-(pyridin-4-yloxy)pyrrolidin-l-yl)propanamide The title product was afforded by a procedure similar to that described for the synthesis of Example 23 using 2-chloro-2-methylpropanoyl chloride instead of 2-chloropropanoyl chloride. MS (ESI, m / z): 566.3 [M+H]+ Example 26: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-hydro xyazetidin- l-yl)acetamide The title product was afforded by a procedure similar to Step a’ of General Method B using azetidin-3-ol instead of (R)-pyrrolidin-3-ol from Intermediate 002 prepared by Method A. MS (ESI, m / z): 447.2 [M+H]+ Example 27: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-ylmethoxy)azetidin-1-yl) acetamide NH A solution of Example 26 (223 mg, 0.5 mmol) and cesium carbonate (325 mg, 1 mmol) in DMF (2 mL) was treated with 4-(bromomethyl)pyridine (120 mg, 0.7 mmol). Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (100 mg, 37%). MS (ESI, m / z): 538.3 [M+H]+ Example 28: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)azetidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 26 using 4-(azetidin-3-yloxy)pyridine instead of azetidin-3-ol. 4-(azetidin-3-yloxy)pyridine was prepared by a procedure similar to General Method C using tert-butyl 3-hydroxyazetidine-i-carboxylate instead of tert-butyl (R)-3-hydroxypyrrolidine-i-carboxylate. MS (ESI, m / z): 524.2 [M+H]+ Example 29: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrim idin-4-yloxy)azetidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 28 using 4-(azetidin-3-yloxy)pyrimidine instead of 4-(azetidin-3-yloxy)pyridine. MS (ESI, m / z): 525.2 [M+H]+ Example 30: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-3-yloxy)azetidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 28 using 3-(azetidin-3-yloxy)pyridine instead of 4-(azetidin-3-yloxy)pyridine. MS (ESI, m / z): 524.2 [M+H]+ Example 31: Synthesis of methyl 1-(2-((3-(2-((1,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2-oxo ethyl) azetidine-3-carboxylate The title product was afforded by a procedure similar to that described for the synthesis of Example 26 using methyl azetidine-3-carboxylate instead of azetidin-3-ol. MS (ESI, m / z): 489.2 [M+H]+ Example 32: Synthesis of 1-(2-((3-(2-((1,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) am in 0)-2- oxoethyl)azetidine-3-carboxylic acid The title product was afforded by a procedure similar to that described for the synthesis of Example 26 using azetidine-3-carboxylic acid instead of azetidin-3-ol. MS (ESI, m / z): 475.2 [M+H]+ Example 33: Synthesis of N-cyclopropyl-3-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in o)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) am in o )-2-oxo ethyl) azetidin-3-yl) oxy) is oxazole-5-carbo xam ide A solution of Example 26 (446 mg, 1 mmol), methyl 3-hydroxyisoxazole-5-carboxylate (143 mg, 1 mmol) and triphenylphosphine (314 mg, 1.2 mmol) in THF (3 mL) was treated with diisopropyl azodicarboxylate (0.314 mL, 1.6 mmol) and stirred for 2 h. The mixture was concentrated in vacuo and purified by column chromatography (0-30% MeOH in DCM) to give methyl 3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxylate (480 mg, 84%). A solution of methyl 3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxylate (400 mg, 0.7 mmol) in MeOH(i mL) was treated with 1N NaOH in MeOH(o.5 mL) and stirred for 1 h. The mixture was concentrated in vacuo and neutralized with 1N HC1 to give 3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azeti din-3-yl)oxy)isoxazole-5-carboxylic acid quantitatively. A solution of 3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxylic acid (278 mg, 0.5 mmol), cyclopropylamine (60 pL, 0.9 mmol), HATU (460 mg, 1.2 mmol) in DMF (2 mL) was treated with triethylamine (210 pL, 1.5 mmol) and stirred for 2 h. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (200 mg, 67%). MS (ESI, m / z): 597.3 [M+H]+ Example 34: Synthesis of 2-(5,6-dihydro-[4,4'-bipyridin]-l(2H)-yl)- N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)- 1H-indo 1-7-yl) acetamide A solution of Intermediate 002 (818 mg, 2 mmol) prepared by Method A and 4-(4,4,5,5-tetramethyl-i,3,2-dioxaborolan-2-yl)-i,2,3,6-tetrahydropyridine (501 mg, 2.4 mmol) in DMF (3 mL) was treated with triethylamine(o.55 mL, 4 mmol) and stirred for 2 h at 5O°C. The mixture was concentrated in vacuo and purified by column chromatography (0-30% MeOH in DCM) to give N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(4,4,5,5-tetramethyl-i,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-i(2H)-yl)acetamide (720 mg, 62%). MS (ESI, m / z): 583.3 [M+H]+ A solution of N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(4,4,5,5-tetramethyl-i,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-i(2H)-yl)acetamide (29img, 0.5 mmol), Pd(PPh3)4 (s8mg, 0.05 mmol), 4-bromopyridine (126 mg, 0.8 mmol), and K2CO3 (207 mg, 1.5 mmol) in 1,4-dioxane (0.9 mL) and water (0.3 mL) was heated to 8o°C for 12 h. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (lyomg, 64%). MS (ESI, m / z): 534.3 [M+H]+ Example 35: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-(l-methyl-lH-pyrazo 1-4-yl)-5,6-dihydro pyridin-l(2H)-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 34 using 4-bromo-i-methyl-iH-pyrazole instead of 4-bromopyridine. MS (ESI, m / z): 537.3 [M+H]+ Example 36: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(4-(4-methylpiperazin-1-yl) pipe ridin-1-yl) acetamide A solution of Intermediate 002 (818 mg, 2 mmol) prepared by Method A and piperidin-4-ol (303 mg, 3 mmol) in DMF (3 mL) was treated with triethylamine (0.55 mL, 4 mmol) and stirred for 2 h at 5O°C. The mixture was concentrated in vacuo and purified by column chromatography (0-20% MeOH in DCM) to give N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-hydroxypiperidin-i-yl)acetamide (820 mg, 86%). MS (ESI, m / z): 475.2 [M+H]+ A solution of N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-hydroxypiperidin-i-yl)acetamide (711 mg, 1.5 mmol) and mesyl chloride (193 pL, 2.5 mmol) was treated with triethylamine (0.7 mL, 5 mmol) and stirred for 3 h at o°C. The mixture was concentrated in vacuo and purified by column chromatography (0-20% MeOH in DCM) to give 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperidin-4-yl methanesulfonate (620 mg, 75%). MS (ESI, m / z): 553.2 [M+H]+ A solution of 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperidin-4-yl methanesulfonate (552 mg, 1 mmol) and 1-methylpiperazine (2oomg, 2 mmol) in DMF (3 mL) was treated with triethylamine (0.42 mL, 3 mmol) and stirred for 2 h at 5O°C. Then, the mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (310 mg, 55%). MS (ESI, m / z): 557.3 [M+H]+ Example 37: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-morpho lino piperidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using morpholine instead of i-methylpiperazine. MS (ESI, m / z): 544.3 [M+H]+ Example 38: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-(pyridin-3-yloxy) pipe ridin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using pyridin-3-ol instead of i-methylpiperazine. MS (ESI, m / z): 552.3 [M+H]+ Example 39: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-(pyridin-2-yloxy) pipe ridin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using pyridin-2-ol instead of 1-methylpiper azine. MS (ESI, m / z): 552.3 [M+H]+ Example 40: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-(pyridin-4-yloxy) pipe ridin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using pyridin-4-ol instead of 1-methylpiperazine. MS (ESI, m / z): 552.3 [M+H]+ Example 41: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(4-(pyrim idin-2-yloxy) pipe ridin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using pyrimidin-2-ol instead of 1-methylpiperazine. MS (ESI, m / z): 553.3 [M+H]+ Example 42: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(4-((4,6-dimethylpyrim idin-2-yl)oxy)piperidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 36 using 4,6-dimethylpyrimidin-2-ol instead of 1-methylpiperazine. MS (ESI, m / z): 581.3 [M+H]+ Example 43: Synthesis of N-cyclopropyl-3-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) am in 0 )-2-oxo ethyl) pip eridin-4-yl) oxy) is oxazole-5-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 33 using piperidin-4-ol instead of azetidin-3-ol. MS (ESI, m / z): 625.3 [M+H]+ Example 44: Synthesis of N-cyclopropyl-3-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) am in 0 )-2-oxo ethyl) pip eridin-3-yl) oxy) is oxazole-5-carboxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 33 using piperidin-3-ol instead of azetidin-3-ol. MS (ESI, m / z): 625.3 [M+H]+ Example 45: Synthesis of 2-(3-(cyanomethyl)pyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 26 using 2-(pyrrolidin-3-yl)acetonitrile instead of azetidin-3-ol. MS (ESI, m / z): 484.3 [M+H]+ Example 46: Synthesis of (R)-2-(3-(cyanomethyl)pyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-1H-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 26 using (R)-2-(pyrrolidin-3-yl)acetonitrile instead of azetidin-3-0I. MS (ESI, m / z): 484.3 [M+H]+ Example 47: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrim idin-4-ylam in o)pyrro lidin-1-yl) acetamide A solution of Intermediate 002 (410 mg, 1 mmol) prepared by Method A and tert-butyl (S)-pyrrolidin-3-ylcarbamate (223 mg, 1.2 mmol) in DMF (3 mL) was treated with triethylamine(o.29 mL, 2 mmol) and stirred for 2 h at 5O°C. The mixture was concentrated in vacuo and purified by column chromatography (0-20% MeOH in DCM) to give tert-butyl (8)-(1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)carbamate. (520 mg, 93%). MS (ESI, m / z): 560.3 [M+H]+ tert-butyl          (8)-(1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)carbamate (280 mg, 0.5 mmol) was dissolved in 1N HC1 in MeOH(2 mL). The mixture was concentrated in vacuo and purified by column chromatography (0-40% MeOH in DCM) to give (S)-2-(3-aminopyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide quantitatively. MS (ESI, m / z): 460.2 [M+H]+. A solution of (S)-2-(3-aminopyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide (230 mg, 0.5 mmol) and 4-chloropyrimidine (80 mg, 0.7 mmol) in DMF (2 mL) was treated with triethylamine (0.29 mL, 2 mmol) and stirred for 2 h at 5O°C. The mixture was stirred for 2 h and separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimidin-4-ylamino)pyrroli din-1-yl)acetamide (200 mg, 74%). MS (ESI, m / z): 538.3 [M+H]+. Example 48: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrim idin-4-ylam in o)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 47 using tert-butyl (R)-pyrrolidin-3-ylcarbamate instead of tertbutyl (S)-pyrrolidin-3-ylcarbamate. MS (ESI, m / z): 538.3 [M+H]+ Example 49: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-ylam in o)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 48 using 4-chloropyridine instead of 4-chloropyrimidine. MS (ESI, m / z): 537.3 [M+H]+ Example 50: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-((3R,4S)-3-fluoro-4-hydroxypyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to Step a’ of General Method B using (3S,4R)-4-fluoropyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 479.2 [M+H]+ Example 51: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-((3R,4R)-3-fluoro-4-(pyridin-4-yloxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to Step a’ and b’ of General Method B using (3S,4R)-4-fluoropyrrolidin-3-ol and pyridin-4-ol instead of (R)-pyrrolidin-3-ol and 2-chloropyrimidin-4-ol. MS (ESI, m / z): 556.3 [M+H]+ Example 52:      Synthesis of 2-((3R,4S)-3-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)-4-fluoropyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide NH The title product was afforded by a procedure similar to General Method B using (3S,4S)-4-fluoropyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 612.3 [M+H]+ Example 53:      Synthesis of 2-((3R,4R)-3-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)-4-fluoropyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to General Method B using (3S,4R)-4-fluoropyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 612.3 [M+H]+ Example 54:      Synthesis of 2-((3S,4R)-3-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)-4-fluoropyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to General Method B using (3R,4R)-4-fluoropyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 612.3 [M+H]+ Example 55:    Synthesis of methyl (2S,4S)-4-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)-l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2-oxo ethyl) pyrrolidine-2-carboxylate The title product was afforded by a procedure similar to General Method B using methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 652.3 [M+H]+ Example 56:       Synthesis of (2S,4S)-4-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)-l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in o)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in o)-2-oxoethyl)pyrrolidine-2-carboxylic acid OH Example 55 (195 mg, 0.3 mmol) was dissolved in 1N LiOH in MeOH (2 mL). The mixture was stirred for 2 h and separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product quantitatively. MS (ESI, m / z): 638.3 [M+H]+ Example 57:      Synthesis of 2-((2S,4S)-4-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)-2-(hydroxymethyl)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) amino )-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide A solution of Example 55 (326 mg, 0.5 mmol) in THF (1 mL) was treated with LAH (1N in THF, 1 mL) at o°C and stirred for 4 h. The mixture was diluted with EA(5 mL), washed with water(5 mL x 2), concentrated in vacuo. The crude was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (120 mg, 38%). MS (ESI, m / z): 624.3 [M+H]+ Example 58:       Synthesis of (2S,4S)-4-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)-l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in o)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in o)-2-oxoethyl)pyrrolidine-2-carboxam ide H NH2 A solution of Example 56 (320 mg, 0.5 mmol), HATU(3O4 mg, 0.8 mmol) and NH4OH(3O% solution, 30 pL) in DMF (2 mL) was treated with triethylamine (280 pL, 2 mmol) and stirred for ih. The mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (95 mg, 29%). MS (ESI, m / z): 637-3 [M+H]+ Example 59: Synthesis of 2-((2S,4S)-2-(aminomethyl)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide A solution of Example 58 (63 mg, 0.1 mmol) in THF (imL) was treated with LAH (1N in THF, 1 mL) at o°C and stirred for 4 h. The mixture was diluted with EA(3 mL), washed with water(3 mL x 2), concentrated in vacuo. The crude was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (23 mg, 37%). MS (ESI, m / z): 623.3 [M+H]+ Example       60:       Synthesis       of (S)-2-(3-((2- (cyclo propylam ino)pyrim idin-4-yl)oxy)-2-oxopyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to General Method B using (S)-3-hydroxypyrrolidin-2-one instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 608.3 [M+H]+ Example       61:       Synthesis       of (S)-2-(4-((2- (cyclo propylam ino)pyrimidin-4-yl)oxy)-2-oxopyrrolidin-l-yl)-N-(3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) acetamide The title product was afforded by a procedure similar to General Method B using (S)-4-hydroxypyrrolidin-2-one instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 608.3 [M+H]+ Example 62: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(3-oxopiperazine-l-carbonyl)pyrrolidin-1-yl) acetamide A solution of Intermediate 002(4090 mg, 10 mmol) preparedby Method A and methyl (S)-pyrrolidine-3-carboxylate (1548 mg, 12 mmol) in DMF (20 mL) was treated with triethylamine(2.8 mL, 20 mmol) and stirred for 4 h at 5O°C. The mixture was concentrated in vacuo and purified by column chromatography (0-20% MeOH in DCM) to give methyl (8)-1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-3-carboxylate (4600 mg, 91%). MS (ESI, m / z): 503.2 [M+H]+ (8)-1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-3-carboxylate (4518 mg, 9 mmol) was dissolved in 1N LiOH in MeOH (20 mL). The mixture was concentrated in vacuo and purified by column chromatography (0-50% MeOH in DCM) to give (8)-1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-3-carboxylic acid quantitatively. MS (ESI, m / z): 489.2 [M+H]+ A solution of (8)-1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-3-carboxylic acid (244 mg, 0.5 mmol), HATU(3O4 mg, 0.8 mmol) and piperazin-2-one (70 mg, 0.7 mmol) in DMF (2 mL) was treated with triethylamine (280 pL, 2 mmol) and stirred for 3h. The mixture was separated from the UCT SPE CUBCX cartridge and purified by the Prep HPLC to afford a corresponding product (160 mg, 56%). MS (ESI, m / z): 571.3 [M+H]+ Example 63: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 62 using morpholine instead of piperazin-2-one. MS (ESI, m / z): 558.3 [M+H]+ Example 64: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(thiomorpholine-4-carbo nyl)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 62 using thiomorpholine instead of piperazin-2-one. MS (ESI, m / z): 574.3 [M+H]+ Example 65: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(4-methylpiperazine-l-carbonyl)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 62 using methyl (R)-pyrrolidine-3-carboxylate and 1-methylpiperazine instead of methyl (S)-pyrrolidine-3-carboxylate and piperazin-2-one. MS (ESI, m / z): 571.3 [M+H]+ Example 66: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(3-oxopiperazine-l-carbonyl)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 65 using piperazin-2-one instead of 1-methylpiperazine. MS (ESI, m / z): 571.3 [M+H]+ Example 67: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 65 using morpholine instead of 1-methylpiperazine. MS (ESI, m / z): 558.3 [M+H]+ Example 68: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(thiomorpholine-4-carbo nyl)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 65 using thiomorpholine instead of 1-methylpiperazine. MS (ESI, m / z): 574.3 [M+H]+ Example 69: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(l,2,3,6-te trahydro pyridine-l-carbonyl)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 62 using 1,2,3,6-tetrahydropyridine instead of piperazin-2-one. MS (ESI, m / z): 554-3 [M+H]+ Example 70: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3- hydro xypyrro lidin -1-yl) ace tam ide NH OH The title product was afforded by a procedure similar to Step a’ of General Method B using pyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol from Intermediate 002 prepared by Method A. MS (ESI, m / z): 461.2 [M+H]+ Example 71: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3- hydro xypyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to Step a’ of General Method B from Intermediate 002 prepared by Method A. MS (ESI, m / z): 461.2 [M+H]+ Example 72: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3- hydro xypyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to Step a’ of General Method B using (S)-pyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol from Intermediate 002. MS (ESI, m / z): 461.2 [M+H]+ Example 73: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-2-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 39 using (R)-pyrrolidin-3-ol instead of piperidin-4-ol. MS (ESI, m / z): 538.3 [M+H]+ Example 74: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using pyridin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 538.3 [M+H]+ Example 75: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-3-yloxy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using pyridin-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 538.3 [M+H]+ Example 76: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 74 using pyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 538.3 [M+H]+ Example 77: Synthesis of (R)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 74 using (S)-pyrrolidin-3-ol instead of (R)-pyrrolidin-3-ol. MS (ESI, m / z): 538.3 [M+H]+ Example 78: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrim idin-4-yloxy)pyrrolidin-1-yl) acetamide NH The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using pyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 539-3 [M+H]+ Example 79: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(pyrazin-2-yloxy)pyrrolidin-1-yl) acetamide NH The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using pyrazin-2-ol instead of pyridin-2-ol. MS (ESI, m / z): 539-3 [M+H]+ Example 80: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(4- fluoro phe no xy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 4-fluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 555-3 [M+H]+ Example 81: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(3- fluoro phe no xy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-fluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 555-3 [M+H]+ Example 82: Synthesis of (S)-2-(3-(4-chlorophenoxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) amino )-5-me th yip yrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 4-chlorophenol instead of pyridin-2-ol. MS (ESI, m / z): 571.2 [M+H]+ Example 83: Synthesis of (8)-2-(3-(2,4- difluo ro phen oxy)pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2,4-difluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 573.3 [M+H]+ Example 84:       Synthesis of (S)-2-(3-(3,4- difluo ro phen oxy)pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3,4-difluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 573.3 [M+H]+ Example 85:      Synthesis of (S)-2-(3-(2-chloro-4- fluorophenoxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-chloro-4-fluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 589.2 [M+H]+ Example 86: Synthesis of (8)-2-(3-(3,5- difluo ro phen oxy)pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3,5-difluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 573.3 [M+H]+ Example 87:     Synthesis of (S)-2-(3-(3-amino-4- fluorophenoxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide NH NH2 The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-amino-4-fluorophenol instead of pyridin-2-ol. MS (ESI, m / z): 570.3 [M+H]+ Example 88:        Synthesis of (S)-2-(3-(3- (diethylam in 0) phen oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH- pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-(diethylamino)phenol instead of pyridin-2-ol. MS (ESI, m / z): 608.3 [M+H]+ Example 89: Synthesis of (S)-2-(3-(3-aminophenoxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) amino )-5-me th yip yrim idin-4-yl)-lH-in do 1-7-yl) acetamide NH NH2 The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-aminophenol instead of pyridin-2-ol. MS (ESI, m / z): 552.3 [M+H]+ Example 90: Synthesis of (S)-2-(3-((2-aminopyridin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m e th yip yrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide nh2 The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-aminopyridin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 553.3 [M+H]+ Example 91: Synthesis of (S)-2-(3-((2-chloropyridin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-chloropyridin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 572.2 [M+H]+ Example 92: Synthesis of (S)-2-(3-((6-aminopyrazin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide NH The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 6-aminopyrazin-2-ol instead of pyridin-2-ol. MS (ESI, m / z): 554.3 [M+H]+ Example 93: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((5- fluoro pyrim idin-2-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-fluoropyrimidin-2-ol instead of pyridin-2-ol. MS (ESI, m / z): 557.3 [M+H]+ Example 94: Synthesis of (S)-2-(3-((6-chloro-5-methylpyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 6-chloro-5-methylpyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 587.2 [M+H]+ Example 95: Synthesis of(S)-2-(3-((2-amino-6-methylpyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-amino-6-methylpyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 568.3 [M+H]+ Example 96: Synthesis of (S)-2-(3-((5-amino-2-chloropyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-amino-2-chloropyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 588.2 [M+H]+ Example 97: Synthesis of(S)-2-(3-((5-bromo-2-methylpyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-bromo-2-methylpyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 631.2 [M+H]+ Example 98: Synthesis of (S)-2-(3-((2-amino-6-(5-chloro-2-fluorophenyl)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl- lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide h2n The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-amino-6-(5-chloro-2-fluorophenyl)-2-methylpyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 682.3 [M+H]+ Example 99:     Synthesis of (S)-2-(3-((2-amino-6- (trifluorom ethyl)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5- dim ethyl-IH-pyrazo 1-3-yl) am in0)-5-m ethylpyrim idin-4-yl)-lH-indol-7- yl)acetamide h2n The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-amino-6-(trifluoromethyl)pyrimidin-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 622.3 [M+H]+ Example 100: Synthesis of (S)-2-(3-([l,l'-biphenyl]-4-yloxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using [i,i'-biphenyl]-4-ol instead of pyridin-2-ol. MS (ESI, m / z): 613.3 [M+H]+ Example 101: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(4-(2- phen ylpro pan-2-yl) phen oxy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 4-(2-phenylpropan-2-yl)phenol instead of pyridin-2-ol. MS (ESI, m / z): 655-3 [M+H]+ Example 102: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((5-pen tylpyrimidin-2-yl)oxy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-pentylpyrimidin-2-ol instead of pyridin-2-ol. MS (ESI, m / z): 609.3 [M+H]+ Example 103: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-(4-((4-m ethylpiperazin-1-yl) methyl) pheno xy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 4-((4-methylpiperazin-i-yl)methyl)phenol instead of pyridin-2-ol. MS (ESI, m / z): 649.4 [M+H]+ Example 104: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((l-methyl-lH-pyrazol-5-yl)oxy)pyrrolidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using i-methyl-iH-pyrazol-5-ol instead of pyridin-2-ol. MS (ESI, m / z): 541.3 [M+H]+ Example 105: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((l-methyl-lH-pyrazol-3-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using i-methyl-iH-pyrazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 541.3 [M+H]+ Example 106: Synthesis of methyl (8)-3-((1-(2-((3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino )-2-oxo ethyl) pyrro lidin-3 -yl) oxy) benzo [ b ] thio phene-2-carboxylate The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using methyl 3-hydroxybenzo[b]thiophene-2-carboxylate instead of pyridin-2-ol. MS (ESI, m / z): 651.2 [M+H]+ Example 107: Synthesis of methyl (8)-3-((1-(2-((3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) am ino )-2-oxo ethyl) pyrro lidin-3-yl) oxy) thio phene-2-carboxylate The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using methyl 3-hydroxythiophene-2-carboxylate instead of pyridin-2-ol. MS (ESI, m / z): 601.2 [M+H]+ Example 108: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xo ethyl)pyrro lidin-3-yl) oxy) thio phene-2-carboxylic acid The title product was afforded using Example 107 by a procedure similar to that described for the synthesis of Example 56 from Example 55. MS (ESI, m / z): 587.2 [M+H]+ Example 109: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xo ethyl)pyrro lidin-3-yl) oxy) thiophene-2-carboxamide The title product was afforded using Example 107 by a procedure similar to that described for the synthesis of Example 58 from Example 55. MS (ESI, m / z): 586.2 [M+H]+ Example 110: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xoethyl)pyrro lidin-3-yl) oxy)-N-m ethylthio phene-2-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 109 using methylamine instead of ammonium hydroxide. MS (ESI, m / z): 600.2 [M+H]+ Example 111: Synthesis of (S)-N-cyclopropyl-3-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino )-2-oxo e th yl)pyrro lidin-3-yl) oxy) thio phene-2-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 109 using cyclopropylamine instead of ammonium hydroxide. MS (ESI, m / z): 626.3 [M+H]+ Example 112: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((5-m e thylis oxazo 1-3-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-methylisoxazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 542.3 [M+H]+ Example 113: Synthesis of (S)-2-(3-(benzo[d]isoxazol-3-yloxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using benzo[d]isoxazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 578.3 [M+H]+ Example 114: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(isothiazol-3-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using isothiazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 544.2 [M+H]+ Example 115: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((2- m ethylthio phen-3-yl)oxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-methylthiophen-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 557.2 [M+H]+ Example 116:    Synthesis of (S)-2-(3-((lH-pyrazol-3- yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using iH-pyrazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 527.3 [M+H]+ Example 117: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((l-m ethyl-5-(trifluo ro m e thyl)-1H-pyrazo 1-3-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using i-methyl-5-(trifluoromethyl)-iH-pyrazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 609.3 [M+H]+ Example 118: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-(isoxazol-3-yloxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using isoxazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 528.2 [M+H]+ Example 119: Synthesis of (S)-2-(3-((5-amino-lH-pyrazol-3-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-m e thylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide nh2 The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 5-amino-iH-pyrazol-3-ol instead of pyridin-2-ol. MS (ESI, m / z): 542.3 [M+H]+ Example 120: Synthesis of methyl (8)-3-((1-(2-((3-(2-((1,5-dim ethyl-IH-pyrazo 1-3-yl) am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) am in0)-2-oxoethyl)pyrrolidin-3-yl)oxy)-1H-pyrrole-2-carboxylate The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using methyl 3-hydroxy-iH-pyrrole-2-carboxylate instead of pyridin-2-ol. MS (ESI, m / z): 584.3 [M+H]+ Example 121: Synthesis of ethyl (S)-5-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-20 xo e thyl) pyrro lidin-3-yl) oxy) iso xazole-4-carboxylate The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using ethyl 5-hydroxyisoxazole-4-carboxylate instead of pyridin-2-ol. MS (ESI, m / z): 600.3 [M+H]+ Example 122: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH- pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2 0 xo e thyl) pyrro lidin-3-yl) oxy) iso xazole-5-carboxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-hydroxyisoxazole-5-carboxamide instead of pyridin-2-0I. MS (ESI, m / z): 571.3 [M+H]+ Example 123: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-o xoe th yl)p yrro lidin-3-yl)oxy)-N-m e th ylis oxazole-5-carb oxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-hydroxy-N-methylisoxazole-5-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 585.3 [M+H]+ Example 124: Synthesis of (S)-N-cyclopropyl-3-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in0)-5-m ethylpyrim idin-4-yl)-lH-indo 1-7-yl) am in 0 )-2-oxo ethyl) p yrro lidin-3-yl) oxy) is oxazole-5-carb oxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using N-cyclopropyl-3-hydroxyisoxazole-5-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 611.3 [M+H]+ Example 125: Synthesis of (S)-3-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xoe th yl)p yrro lidin-3-yl)oxy)-N,N-dim e th ylis oxazole-5-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 3-hydroxy-N,N-dimethylisoxazole-5-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 599.3 [M+H]+ Example 126: Synthesis of (S)-N-cyclopropyl-2-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2-o xo e th yl) pyrro lidin-3-yl) oxy) oxazole-5-carb oxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using N-cyclopropyl-2-hydroxyoxazole-5-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 611.3 [M+H]+ Example 127: Synthesis of (S)-N-cyclopropyl-2-((l-(2-((3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2-oxo ethyl) pyrro lidin-3-yl) oxy) oxazole-4-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using N-cyclopropyl-2-hydroxyoxazole-4-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 611.3 [M+H]+ Example 128: Synthesis of (S)-2-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in o)-2-oxoethyl)pyrrolidin-3-yl)oxy)pyrim id in e-4-carboxylic acid The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-hydroxypyrimidine-4-carboxylic acid instead of pyridin-2-ol. MS (ESI, m / z): 583.3 [M+H]+ Example 129: Synthesis of (S)-2-((l-(2-((3-(2-((l,5-dimethyl-lH- pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2 0 xo e th yl) pyrro lidin-3-yl) oxy) pyrimidine-4-carb oxam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-hydroxypyrimidine-4-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 582.3 [M+H]+ Example 130: Synthesis of (S)-2-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xo ethyl) pyrro lidin-3-yl)oxy)-N-m ethylpyrim idine-4-carboxam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-hydroxy-N-methylpyrimidine-4-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 596.3 [M+H]+ Example 131: Synthesis of (S)-2-((l-(2-((3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am ino)-2-0 xo ethyl) pyrro lidin-3-yl)oxy)-N,N-dim ethylpyrim idine-4-carboxam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 2-hydroxy-N,N-dimethylpyrimidine-4-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 610.3 [M+H]+ Example 132: Synthesis of (S)-6-((l-(2-((3-(2-((l,5-dimethyl-lH- pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2 0 xo e thyl) pyrro lidin-3-yl) oxy) pyrazine-2-carboxamide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 6-hydroxypyrazine-2-carboxamide instead of pyridin-2-0I. MS (ESI, m / z): 582.3 [M+H]+ Example 133: Synthesis of (S)-6-((l-(2-((3-(2-((l,5-dimethyl-lH- pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)am in 0)-2 0 xo ethyl) pyrro lidin-3-yl) 0 xy)-N-m e th yip yrazine-2-carbo xam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 73 using 6-hydroxy-N-methylpyrazine-2-carboxamide instead of pyridin-2-ol. MS (ESI, m / z): 596.3 [M+H]+ Example 134: Synthesis of (S)-2-(3-((4-amino-l,3,5-triazin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to General Method B using 4-chloro-i,3,5-triazin-2-ol and ammonium hydroxide instead of 2-chloropyrimidin-4-ol and cyclopropylamine. MS (ESI, m / z): 555.3 [M+H]+ Example 135: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4- (m e th ylam in 0 )-1,3,5-triazin-2-yl) oxy) pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 134 using methylamine instead of ammonium hydroxide. MS (ESI, m / z): 569.3 [M+H]+ Example 136: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4-(dimethylamino)-l,3,5-triazin-2-yl)oxy)pyrrolidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 134 using dimethylamine instead of ammonium hydroxide. MS (ESI, m / z): 583.3 [M+H]+ Example 137: Synthesis of (S)-2-(3-((4-(cyclopropylamino)-l,3,5-triazin-2-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 134 using cyclopropylamine instead of ammonium hydroxide. MS (ESI, m / z): 595-3 [M+H]+ Example 138: Synthesis of (S)-2-(3-((4,6-diamino-l,3,5-triazin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide h2n The title product was afforded by a procedure similar to that described for the synthesis of Example 134 using 4-amino-6-chloro-i,3,5-triazin-2-ol instead of 4-chloro-i,3,5-triazin-2-ol. MS (ESI, m / z): 570.3 [M+H]+ Example 139: Synthesis of (S)-2-(3-((4-amino-6-(pyrrolidin-l-yl)-1,3,5-triazin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dime thyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 138 using pyrrolidine instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 140: Synthesis of (S)-2-(3-((6-aminopyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 134 using 6-chloropyrimidin-4-ol instead of 4-chloro-i,3,5- triazin-2-ol. MS (ESI, m / z): 554.3 [M+H]+ Example 141: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(m ethylam ino)pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using methylamine instead of ammonium hydroxide. MS (ESI, m / z): 568.3 [M+H]+ Example 142: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(ethylam ino)pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using ethylamine instead of ammonium hydroxide. MS (ESI, m / z): 582.3 [M+H]+ Example 143: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(pro pylam in 0 )pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using n-propylamine instead of ammonium hydroxide. MS (ESI, m / z): 596.3 [M+H]+ Example 144: Synthesis of (S)-2-(3-((6-(butylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using n-butylamine instead of ammonium hydroxide. MS (ESI, m / z): 610.3 [M+H]+ Example 145: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)am ino)pyrim idin-4-yl)oxy)pyrro lidin -1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 2-aminoethan-i-ol instead of ammonium hydroxide. MS (ESI, m / z): 598.3 [M+H]+ Example 146: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((6-((3-hydroxypropyl)am ino)pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tarn ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 3-aminopropan-i-ol instead of ammonium hydroxide. MS (ESI, m / z): 612.3 [M+H]+ Example 147: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((6-((2-m ethoxyethyl)am ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 2-methoxyethan-i-amine instead of ammonium hydroxide. MS (ESI, m / z): 612.3 [M+H]+ Example 148 : Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((6-((3-(dim e th ylam in 0) propyl) amino )pyrim idin-4-yl)oxy)pyrrolidin-l-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using Ni,Ni-dimethylpropane-i,3-diamine instead of ammonium hydroxide. MS (ESI, m / z): 639.4 [M+H]+ Example 149: Synthesis of (S)-2-(3-((6-(benzylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using benzylamine instead of ammonium hydroxide. MS (ESI, m / z): 644-3 [M+H]+ Example 150 : Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(phenethylam ino)pyrim idin-4-yl)oxy)pyrrolidin -1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 2-phenylethan-i-amine instead of ammonium hydroxide. MS (ESI, m / z): 658.3 [M+H]+ Example 151:       Synthesis of (8)-2-(3-((6- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in o)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using cyclopropylamine instead of ammonium hydroxide. MS (ESI, m / z): 594.3 [M+H]+ Example 152:       Synthesis of (8)-2-(3-((6- (cyclo hexylam ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl)am in0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using cyclohexanamine instead of ammonium hydroxide. MS (ESI, m / z): 636.3 [M+H]+ Example 153: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(dim ethylam ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using dimethylamine instead of ammonium hydroxide. MS (ESI, m / z): 582.3 [M+H]+ Example 154: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((6-(ethyl(m ethyl) am ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using N-methylethanamine instead of ammonium hydroxide. MS (ESI, m / z): 596.3 [M+H]+ Example 155: Synthesis of (S)-2-(3-((6-(diethylamino)pyrimidin-4-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using diethylamine instead of ammonium hydroxide. MS (ESI, m / z): 610.3 [M+H]+ Example 156: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-(e thyl(pro pyl) am ino)pyrim idin-4-yl)oxy)pyrro lidin-1-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using N-ethylpropan-i-amine instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 157:       Synthesis of (S)-2-(3-((6- (butyl(ethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using N-ethylbutan-i-amine instead of ammonium hydroxide. MS (ESI, m / z): 638.4 [M+H]+ Example 158: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-( pyrro lid in-1-yl)pyrim idin-4-yl) oxy) pyrro lidin-1-yl) ace tarn ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using pyrrolidine instead of ammonium hydroxide. MS (ESI, m / z): 608.3 [M+H]+ Example 159: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-((3S)-3-((6-(3-hydroxypyrro lidin-1-yl) pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using pyrrolidin-3-ol instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 160: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-((S)-3-((6-((R)-3-hydroxypyrro lidin-1-yl) pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using (R)-pyrrolidin-3-ol instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 161: Synthesis of N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-((S)-3-((6-((S)-3-hydroxypyrro lidin-1-yl) pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using (S)-pyrrolidin-3-ol instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 162: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m e th yip yrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-(pipe ridin-1-yl) pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using piperidine instead of ammonium hydroxide. MS (ESI, m / z): 622.3 [M+H]+ Example 163: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-(4- h ydroxypip eridin-1-yl) pyrim idin-4-yl)oxy)pyrro lidin-1-yl) ace tarn ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using piperidin-4-ol instead of ammonium hydroxide. MS (ESI, m / z): 638.3 [M+H]+ Example 164: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-m orp ho lino pyrim idin-4-yl)oxy)pyrrolidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using morpholine instead of ammonium hydroxide. MS (ESI, m / z): 624.3 [M+H]+ Example 165: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl)-2-(3-((6-(4-m e th yip ip erazin-1-yl) pyrim idin-4 -yl)oxy)pyrro lidin -1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 1-methylpiperazine instead of ammonium hydroxide. MS (ESI, m / z): 637-3 [M+H]+ Example 166:     Synthesis of (S)-2-(3-((2-amino-6- (m ethylam ino)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5- dim ethyl-IH-pyrazo 1-3-yl) am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 141 using 2-amino-6-chloropyrimidin-4-ol instead of 6-chloropyrimidin-4-ol. MS (ESI, m / z): 583.3 [M+H]+ Example 167: Synthesis of (S)-2-(3-((2-amino-6-(pyrrolidin-l-yl)pyrim idin-4-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 166 using pyrrolidine instead of methylamine. MS (ESI, m / z): 623.3 [M+H]+ Example 168: Synthesis of (S)-2-(3-((4-aminopyrimidin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 4-chloropyrimidin-2-ol instead of 6-chloropyrimidin-4-0I. MS (ESI, m / z): 554.3 [M+H]+ Example 169: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4- (m ethylam ino)pyrim idin-2-yl)oxy)pyrro lidin -1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using methylamine instead of ammonium hydroxide. MS (ESI, m / z): 568.3 [M+H]+ Example 170: Synthesis of(S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4-(dim ethylam ino)pyrim idin-2-yl)oxy)pyrrolidin-l-yl)acetam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using dimethylamine instead of ammonium hydroxide. MS (ESI, m / z): 582.3 [M+H]+ Example 171: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4- (ethyl(m ethyl) am ino)pyrim idin-2-yl)oxy)pyrro lidin -1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using N-methylethanamine instead of ammonium hydroxide. MS (ESI, m / z): 596.3 [M+H]+ Example 172: Synthesis of (S)-2-(3-((4-(diethylamino)pyrimidin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using diethylamine instead of ammonium hydroxide. MS (ESI, m / z): 610.3 [M+H]+ Example 173: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4-(pyrrolidin-l-yl)pyrim idin-2-yl)oxy)pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using pyrrolidine instead of ammonium hydroxide. MS (ESI, m / z): 608.3 [M+H]+ Example 174: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am ino)-5-m ethylpyrimidin-4-yl)-lH-indol-7-yl)-2-(3-((4-(piperidin-l-yl) pyrim idin-2-yl) oxy) pyrro lidin-1-yl) ace tam ide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using piperidine instead of ammonium hydroxide. MS (ESI, m / z): 622.3 [M+H]+ Example 175:       Synthesis of (S)-2-(3-((4- (cyclopropylamino)pyrimidin-2-yl)oxy)pyrrolidin-l-yl)-N-(3-(2-((l,5-dim ethyl-IH-pyrazo 1-3-yl) am ino)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 168 using cyclopropylamine instead of ammonium hydroxide. MS (ESI, m / z): 594.3 [M+H]+ Example 176: Synthesis of(S)-2-(3-((4-amino-5-fluoropyrimidin-2-yl) oxy) pyrro lidin-1-yl)-N-(3-(2-((1,5-dim ethyl-lH-pyrazol-3-yl) amino )-5m ethylpyrim idin-4-yl)-lH-in do 1-7-yl) acetamide The title product was afforded by a procedure similar to that described for the synthesis of Example 140 using 4-chloro-5-fluoropyrimidin-2-ol instead of 6-chloropyrimidin-4-ol. MS (ESI, m / z): 572.3 [M+H]+ Example 177: Synthesis of (S)-N-(3-(2-((l,5-dimethyl-lH-pyrazol-3-yl)am in 0)-5-m ethylpyrim idin-4-yl)-lH-indol-7-yl)-2-(3-((5-fluoro-4-(m ethylam...

Claims

i. A compound represented by a following Formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof:[Formula (I)]wherein,L1 and L2 each independently represent H; (Ci-5)alkyl optionally substituted with 4- to 6-membered heterocycloalkyl; or L1 and L2 are connected to form a 5- to 6membered ring,M represents H; halogen; (Ci-5)alkyl; (C3-7)cycloalkyl; or (Ci-5)alkoxy,G represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; or -NH2, wherein at least one H of -NH2 is optionally substituted with (Ci-5)alkyl,Y1 represents H; or (Ci-5)alkyl,Z represents -C(=O)-; or -CH2- optionally substituted with one or more (Ci-5)alkyl; or Z is connected to Y1 to form a 5- to 6-membered ring,Y3 represents 4- to 6-membered heterocycloalkyl in which at least one H is optionally and each independently substituted with W1 or W2; or Y3 is connected to Z to form an aryl or a heteroaryl in case that Z is connected to Y1 to form the 5- to 6membered ring, at least one H of the aryl and heteroaryl formed by Y3 and Z is optionally and independently substituted with W3,Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH, -NH2 or -CN; 5- to 7-membered heterocycloalkyloptionally substituted with (Ci-5)alkyl; a heteroaryl optionally substituted with (Ci-5)alkyl; -COR1; -OR2; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with a heteroaryl,R1 represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (C3-7)cycloalkyl,R2 represents (Ci-5)alkyl optionally substituted with a heteroaryl; an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally and each independently substituted with one or more R2a,one or more R2a each independently represents halogen; (Ci-5)alkyl optionally substituted with an aryl, or 5- to 7- membered heterocycloalkyl substituted with (Ci-5)alkyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7- membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -OH; -CF3; (Ci-5)alkoxy optionally substituted with an aryl; an aryl in which at least one H of the aryl is optionally and each independently substituted with halogen; a heteroaryl optionally substituted with (Ci-5)alkyl; thio(Ci-5)alkyl; -CORla; or NR3R4,Rla is represents (Ci-5)alkoxy; -OH; 5-7 membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; or -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (C3-7)cycloalkyl,R3 and R4 each independently represent H; halogen; (Ci-5)alkyl optionally substituted with halogen, -CF3, -OH, (Ci-5)alkoxy, -N-[(Ci-5)alkyl][(Ci-5)alkyl], an aryl or (C3-7)cycloalkyl; (C3-7)cycloalkyl; (Ci-5)alkoxy; an aryl; or -C(=O)(Ci-5)alkyl, andone or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -C=C-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein at least one H of the aryl or the heteroaryl is optionally substituted with one or more R10,Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionallysubstituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12,R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13,R8 represents H; or (Ci-5)alkyl,R9 represents an aryl optionally substituted with -NH2,one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -S(=O)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring,R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-s)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH,R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen,R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 is optionally and each independently substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2,Ru represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH.

2. The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof or the solvate thereof according to claim 1, wherein:Y3 represents azetidinyl; pyrrolidinyl; piperidinyl; tetrahydropyridinyl; or oxopyrrolidinyl, which is optionally substituted with W1 and W2,Wi and W2 each independently represent H; halogen; -OH; (Ci-5)alkyl optionally substituted with -OH or -CN; methylpiperazinyl; morpholinyl; pyridinyl; methylpyrazolyl; -COR1; -OR2; -NH2; -NH(pyridinyl) or -NH(pyrimidinyl),R1 represents (Ci-5)alkoxy; -OH; -NH2; -NH-(C3-7)cycloalkyl; oxopiperazinyl; morpholinyl; thiomorpholinyl; methylpiperazinyl; or tetrahydropyridinyl,R2 represents (Ci-5)alkyl optionally substituted with pyridinyl; halophenyl; dihalophenyl; (amino)halophenyl; (methylpiperazinyl)(methyl)phenyl; (dimehtylamino)phenyl; aminophenyl; diethylamino phenyl; biphenyl; (phenylpropanyl)phenyl;                           (cyclopropylamino)pyrimidinyl;(trifluoroethylamino)pyrimidinyl;         pyridinyl;                   pyrimidinyl;(cyclopropyl)(isoxazole)carboxamide; (dimethyl)pyrimidinyl; pyrazinyl; aminopyridinyl; halopyridinyl; aminopyrazinyl; halopyrimidinyl; (methyl)halopyrimidinyl; (amino)(methyl)pyrimidinyl; (amino)halopyrimidinyl; dihalopyrimidinyl;                               amino(dihalophenyl)pyrimidinyl;(amino)(trifluoromethyl)pyrimidinyl; pentylpyrimidinyl; methylpyrazolyl; methyl(benzothiophene)carboxylate;                methyl(thiophene)carboxylate;(thiophene)carboxylic               acid;                (thiophene)carboxamide;methyl(thiophene)carboxamide;              cyclopropyl(thiophene)carboxamide;methylisoxazolyl; benzoisoxazolyl; isothiazolyl; methylthiophenyl; pyrazolyl; (methyl)(trifluoromethyl)pyrazolyl;           isoxazolyl;           aminopyrazolyl;methyl(pyrrole)carboxylate; ethyl(isoxazole)carboxylate; (isoxazole)carboxamide; methyl(isoxazole)carboxamide;                  dimethyl(isoxazole)carboxamide;cyclopropyl(oxazole)carboxamide;           (pyrimidine)carboxylic           acid;(pyrimidine)carboxamide;                       methyl(pyrimidine)carboxamide;dimethyl(pyrimidine)carboxamide;                        (pyrazine)carboxamide;methyl(pyrazine)carboxamide; aminotriazinyl; (methylamino)triazinyl; (dimethylamino)triazinyl; (cyclopropylamino)triazinyl; diaminotriazinyl; (amino) (pyrrolidinyl)triazinyl; aminopyrimidinyl; (methylamino)pyrimidinyl; (ethylamino)pyrimidinyl; (propylamino)pyrimidinyl; (butylamino)pyrimidinyl; (hydroxyethylamino)pyrimidinyl;               (hydroxypropylamino)pyrimidinyl;(methoxyethylamino)pyrimidinyl; (((dimethylamino)propyl)amino)pyrimidinyl; (benzylamino)pyrimidinyl;                         (phenethylamino)pyrimidinyl;(cyclohexylamino)pyrimidinyl;                        (dimethylamino)pyrimidinyl;(ethylmethylamino)pyrimidinyl;(ethylpropylamino)pyrimidinyl;(diethylamino)pyrimidinyl;(butylethylamino)pyrimidinyl;pyrrolidinylpyrimidinyl; (hydroxypyrrolidinyl)pyrimidinyl; piperidinylpyrimidinyl;(hydroxypiperi dinyl)pyrimidinyl;(methylpiperazinyl)pyrimidinyl;(amino)(pyrrolidinyl)pyrimidinyl;(ethylamino)halopyrimidinyl;(cyclohexylamino)halopyrimidinyl;(ethylmethylamino)halopyrimidinyl;(methylphenylamino)halopyrimidinyl;(pyrrolidinyl)halopyrimidinyl;(morpholino)halopyrimidinyl;(methylpiperazinyl)halopyrimidinyl;morpholinopyrimidinyl:(amino) (methylamino)pyrimidinyl:(methylamino)halopyrimidinyl(cyclopropylamino)halopyrimidinyl (dimethylamino)halopyrimidinyl (diethylamino)halopyrimidinyl: (benzylmethylamino)halopyrimidinyl (piperidinyl)halopyrimidinyl: (thiomorpholino)halopyrimidinyl (cyclopropylamino)methylpyrimidinyl(amino)pyrimidinyl; (methylthio)pyrimidinyl; (methoxy)pyrimidinyl; (benzyloxy)pyrimidinyl; acetamidopyrimidinyl; (difluoropropylamino)pyrimidinyl; (difluoroethylamino)pyrimidinyl;               (trifluoropropylamino)pyrimidinyl;(fluoroethylamino)pyrimidinyl;                      (cyclobutylamino)pyrimidinyl;(cyclopentylamino)pyrimidinyl;         (isopropylamino)pyrimidinyl;         (sec-butylamino)pyrimidinyl;                   ((cyclopropylmethyl)amino)pyrimidinyl;(((dimethylamino)ethyl)amino)pyrimidinyl;(((dimethylamino)propyl)amino)pyrimidinyl;         (methoxyamino)pyrimidinyl;(benzylmethylamino)pyrimidinyl;               (cyclohexylamino)halopyrimidinyl;(cyclopropylmethylamino)halopyrimidinyl;         (benzylamino)halopyrimidinyl;(cyclopropylamino)halopyrimidinyl;         (cyclopropylamino)methylpyrimidinyl;(cyclopropylamino)(trifluoromethyl)pyrimidinyl;(cyclopropylamino)(methoxy)pyrimidinyl;            (cyclopropylamino)pyrazinyl;(ethylamino)pyrazinyl; (propylamino)pyrazinyl;   (hydroxyethylamino)pyrazinyl;(((dimethylamino)ethyl)amino)pyrazinyl;                       phenylpyrimidinyl;(methylpyrazolyl)pyrimidinyl;                  (dimethylcyclohexenyl)pyrimidinyl;dihydropyranylpyrimidinyl; or pyridinylpyrimidinyl.

3. The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to claim 1, wherein the compoundrepresented by formula (I) above is a compound represented by a following Formula (lb):[Formula (lb)]HX represents -CH2-; or -C(=O)-,V1, V2, V3 and V4 each independently represent CH or N, wherein one or more H of V1, V2, V3 and V4 is optionally and each independently substituted with W3 in case that all of V1, V2, V3 and V4 are not N,one or more W3 each independently represents H, halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -C=C-R9; (C5-6)cycloalkenyl; 5- to 7membered heterocycloalkyl optionally substituted with (Ci-5)alkyl, -C(=O)O(Ci-5)alkyl, -S(=O)2(Ci-5)alkyl, -C(=O)(Ci-5)alkyl or -C(=0)(NH2); an aryl; or a heteroaryl, wherein the aryl or the heteroaryl is optionally substituted with one or more R10,Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or an aryl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; an aryl; -C(=O)RU; or -S(=0)2R12,R7 represents (Ci-5)alkyl optionally substituted with -OH; an aryl optionally substituted with halogen; or -C(=O)R13,R8 represents H; or (Ci-5)alkyl,R9 represents an aryl optionally substituted with -NH2,one or more R10 each independently represents H; halogen; -CN; -CF3; -OH; -OCF3; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl, 5- to 7-membered heterocycloalkyl, or -OH; (Ci-5)alkoxy; -NH2 optionally substituted with one or more (Ci-5)alkyl or -C(=O)O(Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl; -C(=O)R14; -8(=0)2-(5- to 7-membered heterocycloalkyl); or an aryl, wherein R10 is optionally connected to each other to form 5- to 6-membered ring,R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, an aryl, or a hydroxyaryl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl optionally substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with an aryl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; 5- to 7-membered heterocycloalkyl optionally substituted with (Ci-5)alkyl or -NH2; an aryl; or a heteroaryl optionally substituted with (Ci-5)alkyl or -OH,R12 represents (Ci-5)alkyl; or an aryl in which at least one H of the aryl is optionally and each independently substituted with (Ci-5)alkyl or halogen,R!3 represents (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -NH2, wherein at least one H of -NH2 optionally substituted with (Ci-5)alkyl or (Ci-5)alkyl substituted with OH; (C3-7)cycloalkyl; hydroxy(Ci-5)alkyl; (Ci-5)alkoxy(Ci-5)alkyl; -NH2,R!4 represents 5- to 7-membered heterocycloalkyl; -NH2; or -OH,L1, L2, M, and G are as defined in claim 1.

4. The compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to claim 3, wherein:W3 independently represents H; halogen; (Ci-5)alkyl; (Ci-5)alkoxy; -OH; -N02; -NR5R6; -CH=CR7R8; -OC-R9; (C5-6)cycloalkenyl; morpholinyl; tetrahydropyridinyl; dihydropyranyl;            / er / -butyl(tetrahydropyridine)carboxylate;           tert-butyl(dihydropyridine)carboxylate; dihydrothiopyranyl; methyltetrahydropyridinyl; (methylsulfonyl)tetrahydropyridinyl;                      acetyltetrahydropyridinyl;(tetrahydropyridine)carboxamide;     1,1-di oxide-dihydro thiopyranyl;     phenyl;(trifluoromethoxy)phenyl; aminophenyl; / er / -butyl(phenyl)carbamate; (pyrrolidinylsulfonyl)phenyl; oxopiperidine(carbonyl)phenyl; methylpiperazinyl;(methylpiperazinyl)phenyl; isoindolyl; cyanophenyl; cyanohalophenyl; (trifluoromethyl)phenyl; (dimethylamino)phenyl; hydroxybenzyl; methoxyphenyl; biphenyl; methylphenyl; hydroxyphenyl; dihydroindenyl; benzoic acid; methylbenzoate; pyridinyl; pyrazolyl; methylpyrazolyl; furanyl; aminopyridinyl; halopyridinyl; hydroxypyridinyl; (methoxy)halopyridinyl; methoxypyridinyl; (methyl)halopyridinyl;            piperazinylpyridinyl;            pyrrolopyridinyl;(dimethylamino)pyrimidinyl;                        (cyclopropylmethyl)pyrazolyl;(morpholinoethyl)pyrazolyl;            pyrimidinyl;            aminopyrimidinyl;(methylpiperazinyl)pyridinyl; piperazinylpyrimidinyl; morpholinopyridinyl; dihalopyridinyl; methylpyridinyl; pyrrolyl; / er / -butyl(pyrrole)carboxylate; dimethylisoxazolyl; isoquinolinyl; methylindazolyl; methylthiophenyl; indazolyl; thiophenyl; cyanopyridinyl; (hydroxymethyl)pyridinyl; picolinamide; (dimethylamino)pyridinyl; dimethylpyridinyl; or (methylamino)pyridinyl,Rs and R6 each independently represent H; (Ci-5)alkyl optionally substituted with (C3-7)cycloalkyl or phenyl; morpholinyl, or piperazinyl optionally substituted with (Ci-5)alkyl; phenyl; -C(=O)Rn; or -S(=0)2R12,R7 represents methyl optionally substituted with -OH; phenyl optionally substituted with halogen; or -C(=O)R13,R9 represents phenyl optionally substituted with -NH2,R11 represents (Ci-5)alkyl optionally substituted with -N(CH3)2, phenyl, or hydroxyphenyl; (C3-7)cycloalkyl optionally comprising C(=O); (C3-7)cycloalkyl substituted with (Ci-5)alkyl; (C3-7)cycloalkyl fused with phenyl; (C5-6)cycloalkenyl optionally substituted with (Ci-5)alkyl; morpholinyl; methylpiperidinyl; oxopyrrolidinyl; oxoimidazolidinyl; pyrrolidinyl; piperidinyl; tetrahydrofuranyl; tetrahydropyranyl; methyltetrahydropyranyl; aminopyrrolidinyl; methylpyrrolidinyl; phenyl; pyridinyl; oxazolyl; pyridazinyl; methylisoxazolyl; methyloxazolyl; isoxazolyl; methylpyridinyl; furanyl; or hydroxypyrimidinyl,R12 represents (Ci-5)alkyl; phenyl; methylphenyl; or (methyl)halophenyl,Ru represents oxopiperidinyl; -NH2; or -OH.

5. A compound, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein the compound is one selected from the group consisting of the following compounds:1) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-fluoro-iH-indol-7-yl)acetamide 2) (S)-N-(5-amino-3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 3) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-(dimethylamino)-iH-indol-7-yl)acetamide 4) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6 -methoxy- iH-indol-7-yl) acetamide 5) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-(dimethylamino)-iH-inden-7-yl)-2-(3-((2-((2,2,2-trifhioroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 6) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-6-methoxy-iH-indol-7-yl)-2-(3-((2-((2,2,2- trifhioroethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 7) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)acetamide 8) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-fluoropyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 9) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 10) (S)-N-(3-(5-chloro-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 11) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-ethylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 12) (S)-N-(3-(5-cyclopropyl-2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2- (cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 13) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N- (3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)- iH-indol-7-yl)acetamide 14) (S)-2-(3-((3-(cyclopropylamino)-i,2,4-triazin-5-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methoxypyrimidin-4-yl)-iH-indol-7-yl)acetamide 15) (S)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimidin-4-yloxy)pyrrolidin-i-yl)acetamide16) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((5,6-dihydro-4H-pyrrolo[i,2-b]pyrazol-2-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 17) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(5-methyl-2-((5-methyl-i-(2-morpholinoethyl)-iH-pyrazol-3-yl)amino)pyrimidin-4-yl)-iH-indol-7-yl)acetamide 18) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yljacetamide 19) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-oxo-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 20) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-oxoacetamide 21) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-N-methyl-2-(3-(pyrimidin-4-yloxy)pyrrolidin-i-yl)acetamide 22) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(pyrrolidin-i-yl)propanamide 23) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-2-((S)-3-(pyridin-4-yloxy)pyrrolidin-i-yl)propanamide 24) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-methyl-2-(pyrrolidin-i-yl)propanamide 25) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-methyl-2-(3-(pyri din-4 -yloxy)pyrrolidin-i-yljpropanamide 26) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-hydroxyazetidin-i-yl)acetamide 27) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylmethoxy)azetidin-i-yl)acetamide 28) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)azetidin-i-yl)acetamide 29) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimidin-4-yloxy)azetidin-i-yl)acetamide 30) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)azetidin-i-yl)acetamide 31) methyl 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3- carboxylate 32) 1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidine-3-carboxylic acid 33) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)azetidin-3-yl)oxy)isoxazole-5-carboxamide 34) 2-(5,6-dihydro-[4,4'-bipyridin]-i(2H)-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide35) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(i-methyl-iH-pyrazol-4-yl)-5,6-dihydropyridin-i(2H)-yl)acetamide 36) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-2-(4-(4-methylpiperazin-i-yl)piperidin-i-yl)acetamide 37) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-morpholinopiperidin-i-yl)acetamide 38) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(pyridin-3-yloxy)piperidin-i-yl)acetamide 39) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(pyridin-2-yloxy)piperidin-i-yl)acetamide 40) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(pyridin-4-yloxy)piperidin-i-yl)acetamide 41) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-(pyrimidin-2-yloxy)piperidin-i-yl)acetamide 42) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(4-((4,6-dimethylpyrimidin-2-yl)oxy)piperi din-1-yl)acetamide 43) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperi din-4-yl)oxy)isoxazole-5-carboxamide 44) N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)piperi din-3-yl)oxy)isoxazole-5-carboxamide 45) 2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol- 3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 46) (R)-2-(3-(cyanomethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 47) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4 -ylamino)pyrrolidin-i-yljacetamide 48) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4 -ylamino)pyrrolidin-i-yljacetamide 49) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-ylamino)pyrrolidin-i-yl)acetamide 50) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3R,4S)-3-fluoro-4-hydroxypyrrolidin-i-yl)acetamide 51) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3R,4R)-3-fluoro-4-(pyridin-4-yloxy)pyrroli din-1-yl)acetamide 52) 2-((3R,4S)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 53) 2-((3R,4R)-3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-4- fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide54) 2-((38,4R)-3-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-4-fluoropyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 55) methyl (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH- indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylate 56) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxylic acid 57) 2-((28,4S)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)-2-(hydroxymethyl)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 58) (2S,4S)-4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxamide 59) 2-((28,4S)-2-(aminomethyl)-4-((2-(cyclopropylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 60) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 61) (S)-2-(4-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)-2-oxopyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 62) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yljacetamide 63) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrroli din-1-yljacetamide 64) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 65) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(4-methylpiperazine-i-carbonyl)pyrrolidin-i-yljacetamide 66) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(3-oxopiperazine-i-carbonyl)pyrrolidin-i-yl)acetamide 67) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(morpholine-4-carbonyl)pyrroli din-1-yljacetamide 68) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(thiomorpholine-4-carbonyl)pyrroli din-1-yl)acetamide 69) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(i,2,3,6-tetrahydropyridine-i-carbonyl)pyrrolidin-i-yl)acetamide70) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 71) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 72) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-hydroxypyrrolidin-i-yl)acetamide 73) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-2-yloxy)pyrrolidin-i-yl)acetamide 74) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 75) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-3-yloxy)pyrrolidin-i-yl)acetamide 76) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 77) (R)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyridin-4-yloxy)pyrrolidin-i-yl)acetamide 78) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrimi din-4-yloxy)pyrrolidin-i-yl)acetamide 79) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(pyrazin-2-yloxy)pyrrolidin-i-yl)acetamide 80) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(4-fluorophenoxy)pyrrolidin-i-yl)acetamide 81) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(3-fluorophenoxy)pyrrolidin-i-yl)acetamide 82) (S)-2-(3-(4-chlorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 83) (8)-2-(3-(2,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 84) (8)-2-(3-(3,4-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 85) (S)-2-(3-(2-chloro-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 86) (8)-2-(3-(3,5-difluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 87) (S)-2-(3-(3-amino-4-fluorophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 88) (S)-2-(3-(3-(diethylamino)phenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 89) (S)-2-(3-(3-aminophenoxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 90) (S)-2-(3-((2-aminopyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5- dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide91) (S)-2-(3-((2-chloropyridin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 92) (S)-2-(3-((6-aminopyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 93) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yljacetamide 94) (S)-2-(3-((6-chloro-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 95) (S)-2-(3-((2-amino-6-methylpyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 96) (S)-2-(3-((5-amino-2-chloropyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 97) (S)-2-(3-((5-bromo-2-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 98) (S)-2-(3-((2-amino-6-(5-chloro-2-fluorophenyl)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 99) (S)-2-(3-((2-amino-6-(trifluorornethyl)pyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 100) (S)-2-(3-([i,i'-biphenyl]-4-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl- iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 101) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(4-(2-phenylpropan-2-yl)phenoxy)pyrrolidin-i-yl)acetamide 102) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-pentylpyrimidin-2-yl)oxy)pyrrolidin-i-yljacetamide 103) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(4-((4-methylpiperazin-i- yl)methyl)phenoxy)pyrrolidin-i-yl)acetamide 104) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-5-yl)oxy)pyrrolidin-i-yljacetamide 105) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 106) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)benzo[b]thiophene-2-carboxylate107) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3- yl)oxy)thiophene-2-carboxylate 108) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)thiophene-2-carboxylic acid 109) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)thiophene-2-carboxamide no) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N-methylthiophene-2-carboxamide in) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3- yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)thiophene-2-carboxamide 112) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-methylisoxazol-3-yl)oxy)pyrrolidin-i-yljacetamide 113) (S)-2-(3-(benzo[d]isoxazol-3-yloxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 114) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(isothiazol-3-yloxy)pyrrolidin-i-yl)acetamide 115) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-methylthiophen-3-yl)oxy)pyrrolidin-i-yljacetamide 116) (S)-2-(3-((iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl- iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 117) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((i-methyl-5-(trifluorornethyl)-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)acetamide 118) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-(isoxazol-3-yloxy)pyrrolidin-i-yl)acetamide 119) (S)-2-(3-((5-amino-iH-pyrazol-3-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 120) methyl (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)-iH-pyrrole-2-carboxylate 121) ethyl (8)-5-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3- yl)oxy)isoxazole-4-carboxylate 122) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)isoxazole-5-carboxamide 123) (8)-3-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N-methylisoxazole-5-carboxamide124) (S)-N-cyclopropyl-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)isoxazole-5-carboxamide 125) (S)-3-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N,N-dimethylisoxazole-5-carboxamide 126) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-5-carboxamide 127) (S)-N-cyclopropyl-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)oxazole-4-carboxamide 128) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)pyrimidine-4-carboxylic acid 129) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)pyrimidine-4-carboxamide 130) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)-N-methylpyrimidine-4-carboxamide 131) (S)-2-((i-(2-((3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrrolidin-3-yl)oxy)-N,N-dimethylpyrimidine-4-carboxamide 132) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl)oxy)pyrazine-2-carboxamide 133) (8)-6-((1-(2-((3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)amino)-2-oxoethyl)pyrroli din-3-yl) oxy)-N-methylpyrazine- 2 -carboxamide 134) (S)-2-(3-((4-amino-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 135) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 136) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 137) (S)-2-(3-((4-(cyclopropylamino)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 138) (8)-2-(3-((4,6-diamino-i,3,5-triazin-2-yl)oxy)pyrroli din-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 139) (S)-2-(3-((4-amino-6-(pyrrolidin-i-yl)-i,3,5-triazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide140) (S)-2-(3-((6-aminopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 141) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(methylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 142) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 143) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 144) (S)-2-(3-((6-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 145) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 146) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((3-hydroxypropyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 147) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-rnethoxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 148) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((3- (dimethylamino)propyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 149) (S)-2-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 150) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(phenethylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 151) (S)-2-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 152) (S)-2-(3-((6-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 153) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(dimethylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 154) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(methyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 155) (S)-2-(3-((6-(diethylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide156) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethyl(propyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 157) (S)-2-(3-((6-(butyl(ethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 158) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(pyrrolidin-i-yl)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 159) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3S)-3-((6-(3-hydroxypyrrolidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 160) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((S)-3-((6-((R)-3-hydroxypyrrolidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 161) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((S)-3-((6-((S)-3-hydroxypyrrolidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 162) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(piperidin-i-yl)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 163) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-hydroxypiperi din-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 164) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 165) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 166) (S)-2-(3-((2-amino-6-(methylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 167) (S)-2-(3-((2-amino-6-(pyrrolidin-i-yl)pyrimi din-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 168) (S)-2-(3-((4-aminopyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 169) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(methylamino)pyrimidin-2- yl)oxy)pyrrolidin-i-yl)acetamide 170) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)pyrimidin-2- yl)oxy)pyrrolidin-i-yl)acetamide 171) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide172) (S)-2-(3-((4-(diethylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 173) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(pyrrolidin-i-yl)pyrimidin-2- yl)oxy)pyrrolidin-i-yl)acetamide 174) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(piperidin-i-yl)pyrimidin-2- yl)oxy)pyrrolidin-i-yl)acetamide 175) (S)-2-(3-((4-(cyclopropylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 176) (S)-2-(3-((4-amino-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 177) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(methylamino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 178) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 179) (S)-2-(3-((4-(cyclopropylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 180) (S)-2-(3-((4-(cyclohexylamino)-5-fluoropyrimidin-2-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 181) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(dimethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 182) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(ethyl(methyl)amino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 183) (S)-2-(3-((4-(diethylamino)-5-fluoropyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 184) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(methyl(phenyl)amino)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 185) (S)-2-(3-((4-(benzyl(methyl)amino)-5-fluoropyrimidin-2- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 186) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(pyrrolidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 187) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(piperidin-i-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide188) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-morpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 189) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-thiomorpholinopyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 190) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-4-(4-methylpiperazin-i- yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 191) (S)-2-(3-((4-(cyclopropylamino)-5-methylpyrimidin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 192) (S)-2-(3-((2-aminopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 193) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylthio)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 194) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-methoxypyrimi din-4 -yl)oxy)pyrrolidin-i-yljacetamide 195) (S)-2-(3-((2-(benzyloxy)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 196) (S)-2-(3-((2-acetamidopyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 197) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(methylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 198) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2,2,2-trifluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 199) (8)-2-(3-((2-((2,2-difluoropropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 200) (8)-2-(3-((2-((2,2-difluoroethyl)amino)pyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4 -yl) - iH-indol-7-yl) acetamide 201) N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-((3S)-3-((2-((i,i,i-trifluoropropan-2- yl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 202) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-fluoroethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 203) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(ethylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide204) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(propylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 205) (S)-2-(3-((2-(butylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 206) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((3-hydroxypropyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 207) (S)-2-(3-((2-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 208) (S)-2-(3-((2-(cyclobutylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 209) (S)-2-(3-((2-(cyclopentylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 210) (S)-2-(3-((2-(cyclohexylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 211) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(isopropylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 212) 2-((3S)-3-((2-(sec-butylamino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 213) (S)-2-(3-((2-((cyclopropylmethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 214) (S)-2-(3-((2-(benzylamino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 215) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-hydroxyethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 216) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2-rnethoxyethyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 217) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2- (dimethylamino)ethyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 218) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((3- (dimethylamino)propyl)amino)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide219) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(methoxyamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 220) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 221) (S)-2-(3-((2-(benzyl(methyl)amino)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 222) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyrrolidin-i-yl)pyrimidin-4- yl)oxy)pyrrolidin-i-yl)acetamide 223) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(piperidin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide. 224) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide 225) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 226) (S)-2-(3-((2-amino-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 227) (S)-2-(3-((2-(cyclopropylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 228) (S)-2-(3-((2-(cyclohexylamino)-5-fluoropyrimidin-4-yl)oxy)pyrroli din-1-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4 -yl) - iH-indol-7-yl) acetamide 229) (S)-2-(3-((2-((cyclopropylmethyl)amino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 230) (S)-2-(3-((2-(benzylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 231) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)-5-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 232) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-morpholinopyrimidin-4-yl)oxy)pyrrolidin-i-yl)acetamide 233) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-fluoro-2-(4-methylpiperazin-i- yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 234) (S)-2-(3-((2-(cyclopropylamino)-6-fluoropyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide235) (S)-2-(3-((2-(cyclopropylamino)-5-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 236) (S)-2-(3-((2-(cyclopropylamino)-6-methylpyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 237) (S)-2-(3-((2-(cyclopropylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 238) (S)-2-(3-((2-(cyclopropylamino)-6-methoxypyrimidin-4- yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)acetamide 239) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-((2- (dimethylamino)ethyl)amino)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 240) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(dimethylamino)pyrimidin-5- yl)oxy)pyrrolidin-i-yl)acetamide 241) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-morpholinopyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 242) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(4-methylpiperazin-i-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 243) (S)-2-(3-((6-(cyclopropylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)-N-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 244) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(ethylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yljacetamide 245) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(propylamino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 246) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-hydroxyethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 247) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-((2-(dimethylamino)ethyl)amino)pyrazin-2-yl)oxy)pyrrolidin-i-yl)acetamide 248) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-phenylpyrimidin-4-yl)oxy)pyrrolidin-i-yljacetamide 249) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(i-methyl-iH-pyrazol-4-yl)pyrimi din-4-yl)oxy)pyrrolidin-i-yl)acetamide 250) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)arnino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((6-(4,4-dimethylcyclohex-i-en-i- yl)pyrimi din-4 -yl)oxy)pyrrolidin-i-yl)acetamide251) (8)-2-(3-((6-(3,6-dihydro-2H-pyran-4-yl)pyrimi din-4-yl)oxy)pyrroli din-i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 252) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-(4,4-dimethylcyclohex-i-en-i- yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 253) (8)-2-(3-((4-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-2-yl)oxy)pyrrolidin- i-yl)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)acetamide 254) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((4-phenylpyrimidin-2-yl)oxy)pyrrolidin-i-yljacetamide 255) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyridin-3-yl)pyrimidin-2- yl)oxy)pyrrolidin-i-yl)acetamide 256) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((5-(pyri din-4-yl)pyrimidin-2-yl)oxy)pyrrolidin-i-yl)acetamide 257) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-phenylpyrimidin-5-yl)oxy)pyrrolidin-i-yljacetamide 258) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-3-yl)pyrimidin-5- yl)oxy)pyrrolidin-i-yl)acetamide 259) (S)-N-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2-(3-((2-(pyridin-4-yl)pyrimidin-5-yl)oxy)pyrrolidin-i-yl)acetamide 260) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 261) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-fluoroisoindoline-i,3-dione 262) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindoline-i,3-dione 263) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindoline-i,3-dione 264) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-nitroisoindoline-i,3-dione 265) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 266) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 267) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)isoindolin-i-one 268) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-nitroisoindolin-i-one 269) 6-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 270) 5-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one271) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-nitroisoindolin-i-one 272) 4-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 273) 7-chloro-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 274) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitroisoindolin-i-one 275) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodoisoindolin-i-one 276) 7-amino-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 277) 7-brorno-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 278) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-iodoisoindolin-i-one 279) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-methoxyisoindolin-i-one 280) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4,6-dimethoxyisoindolin-i-one 281) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-hydroxyisoindolin-i-one 282) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 283) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-rnethylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoroisoindolin-i-one 284) 6-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 285) 3-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 286) 4-bromo-6-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 287) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 288) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 289) 7-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i,2-dihydro-3H-pyrrolo[3,4- c]pyridin-3-one 290) 4-bromo-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 291) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-5-yl)cyclopropanecarboxamide 292) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)cyclohexanecarboxamide293) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzamide 294) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzamide 295) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohexanecarboxamide 296) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)morpholine-4-carboxamide 297) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 298) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)nicotinamide 299) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-4-carboxamide 300) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopropanecarboxamide 301) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isonicotinamide 302) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyridazine-4-carboxamide 303) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohexane-i-carboxamide 304) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(3- hydroxyphenyl)acetamide 305) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-phenylacetamide 306) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-4-carboxamide 307) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpiperidine-3-carboxamide 308) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 309) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclohex-3-ene-i-carboxamide 310) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopent-3-ene-i-carboxamide 311) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylcyclopent-3-ene-i-carboxamide 312) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cycloheptanecarboxamide313) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-oxoimidazolidine-i-carboxamide 314) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2,3-dihydro-iH-indene-2-carboxamide 315) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 316) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-3-carboxamide 317) (S)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 318) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-oxopyrrolidine-2-carboxamide 319) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)piperidine-3-carboxamide 320) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-oxocyclohexane-i-carboxamide 321) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-4-carboxamide 322) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methyloxazole-4-carboxamide 323) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)oxazole-5-carboxamide 324) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)isoxazole-3-carboxamide 325) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylisoxazole-3-carboxamide 326) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydrofuran-3-carboxamide 327) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-3-carboxamide 328) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methyltetrahydro-2H- pyran-4-carboxamide 329) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylcyclohexane-i-carboxamide330) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylcyclohex-3-ene-i-carboxamide 331) (2R,4S)-4-amino-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)pyrrolidine-2-carboxamide 332) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-methylpiperidine-3-carboxamide 333) (R)-N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-i-methylpyrrolidine-3-carboxamide 334) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5-methylnicotinamide 335) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-(dimethylamino)acetamide 336) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)cyclopentanecarboxamide 337) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)tetrahydro-2H-pyran-4-carboxamide 338) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)furan-3-carboxamide 339) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-6-hydroxypyrimidine-4-carboxamide 340) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-oxoisoindolin-4-yl)benzenesulfonamide 341) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzenesulfonamide 342) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)methanesulfonamide 343) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-methylbenzenesulfonamide 344) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)propane-2-sulfonamide 345) N-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-4-fluoro-3-methylbenzenesulfonamide 346) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(phenylamino)isoindolin-i-one 347) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-morpholinoisoindolin-i-one 348) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(4-methylpiperazin-i-yl)isoindolin-i-one 349) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)isoindolin-i-one 350) 7-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one351) 7-((cyclopropylmethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 352) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-morpholinoisoindolin-i-one 353) 4-((cyclopropylmethyl)amino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 354) 4-(benzylamino)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 355) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(phenylethynyl)isoindolin-i-one 356) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(phenylethynyl)isoindolin-i-one 357) 4-((4-aminophenyl)ethynyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 358) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 359) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)-7-fluoro-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 360) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-dimethylacrylamide 361) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-2-methylacrylamide 362) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-oxobut-i-en-i-yl)isoindolin-i-one 363) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazoi-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-methylacrylamide 364) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethylacrylamide 365) (E)-N-cyclopropyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 366) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylohydrazide 367) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylic acid 368) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N,N-diethylacrylamide 369) (E)-N,N-dibutyl-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 370) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-isopropylacrylamide371) (E)-N-(tert-butyl)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)acrylamide 372) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-hydroxyethyl) acrylamide 373) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-propylacrylamide 374) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-(2-methoxyethyl)acrylamide 375) (E)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-hydroxyprop-i-en-i-yl)isoindolin-i-one 376) (E)-3-(2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-N-ethyl-2-methylacrylamide 377) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-phenylisoindolin-i-one 378) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-5-phenylisoindolin-i-one 379) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-phenylisoindolin-i-one 380) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(pyridin-4-yl)isoindolin-i-one 381) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-6-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 382) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-phenylisoindolin-i-one 383) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)isoindolin-i-one 384) 7-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 385) 7-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 386) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(iH-pyrazol-4-yl)isoindolin-i-one 387) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)isoindolin-i-one 388) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)isoindolin-i-one 389) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-pyrazol-4-yl)isoindolin-i-one 390) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrazol-4-yl)isoindolin-i-one 391) 4-(cyclohex-i-en-i-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 392) 4-(3,6-dihydro-2H-pyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one393) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(furan-3-yl)isoindolin-i-one 394) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyridin-4-yl)isoindolin-i-one 395) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(trifluoromethoxy)phenyl)isoindolin-i-one 396) 4-(4-aminophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 397) tert-butyl 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6- dihydropyridine-i(2H)-carboxylate 398) / er / -butyl (4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)phenyl)carbamate 399) 4-(2-aminopyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 400) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-fluoropyridin-4-yl)isoindolin-i-one 401) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-hydroxypyridin-3-yl)isoindolin-i-one 402) 4-(2-chloropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 403) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoro-2-methoxypyri din-4-yl)isoindolin-i-one 404) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyri din-4-yl)isoindolin-i-one 405) 4-(6-chloropyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 406) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-methoxypyridin-3-yl)isoindolin-i-one 407) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-fluoro-5-methylpyridin-3-yl)isoindolin-i-one 408) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyridin-4-yl)isoindolin-i-one 409) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(pyrrolidin-i-ylsulfonyl)phenyl)isoindolin-i-one 410) (£)-2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin- 4-yl)-iH-indol-7-yl)-4-(3-fluorostyryl)isoindolin-i-one 411) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrolo[2,3-b]pyri din-4-yl)isoindolin-i-one 412) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-oxopiperidine-i-carbonyl)phenyl)isoindolin-i-one 413) 4-(3,6-dihydro-2H-thiopyran-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 414) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyrimidin-5-yl)isoindolin-i-one415) 4-(i-(cyclopropylmethyl)-iH-pyrazol-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 416) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(2-morpholinoethyl)-iH-pyrazol-4-yl)isoindolin-i-one 417) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-5-yl)isoindolin-i-one 418) 4-(2-aminopyrimidin-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 419) 4-(5-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 420) 4-(6-aminopyridin-3-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 421) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyrimidin-4-yl)isoindolin-i-one 422) 4-(2-aminopyrimi din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 423) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)pyridin-2-yl)isoindolin-i-one 424) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(piperazin-i-yl)pyrimidin-5-yl)isoindolin-i-one 425) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(6-morpholinopyridin-3-yl)isoindolin-i-one 426) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(4-methylpiperazin-i-yl)phenyl)isoindolin-i-one 427) 4-(2,6-difluoropyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 428) 4-(3,5-difluoropyridin-4-yl)-2-(3-(2-((i, 5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 429) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)isoindolin-i-one 430) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-[4,5'-biisoindolin]-i-one 431) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-3-yl)isoindolin-i-one 432) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzonitrile 433) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-3-fluorobenzonitrile 434) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(trifluoromethyl)phenyl)isoindolin-i-one 435) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-3-yl)isoindolin-i-one 436) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(dimethylamino)phenyl)isoindolin-i-one 437) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)phenyl)isoindolin-i-one438) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxyphenyl)isoindolin-i-one 439) 4-([i,i'-biphenyl]-2-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 440) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(o-tolyl)isoindolin-i-one 441) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxyphenyl)isoindolin-i-one 442) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-pyrrol-2-yl)isoindolin-i-one 443) / er / -butyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5- methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-iH-pyrrole-i-carboxylate 444) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3,5-dimethylisoxazol-4-yl)isoindolin-i-one 445) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methoxypyridin-4-yl)isoindolin-i-one 446) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-hydroxypyri din-4-yl)isoindolin-i-one 447) 4-(3-aminopyri din-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)- 5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 448) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(isoquinolin-7-yl)isoindolin-i-one 449) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-5-yl)isoindolin-i-one 450) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-iH-indazol-6-yl)isoindolin-i-one 451) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylthiophen-2-yl)isoindolin-i-one 452) 4-(2,3-dihydro-iH-inden-5-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 453) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-methylthiophen-3-yl)isoindolin-i-one 454) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methylpyri din-4 -yl)isoindolin-i-one 455) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-methylpyri din-4-yl)isoindolin-i-one 456) 4-(6-aminopyrimidin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 457) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(iH-indazol-4-yl)isoindolin-i-one 458) 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoic acid 460) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(4-(hydroxymethyl)phenyl)isoindolin-i-one 461) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(thiophen-3-yl)isoindolin-i-one 462) 4-(2-aminophenyl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one463) methyl 2-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)benzoate 464) 2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-methyl-i,2,3,6-tetrahydropyri din-4-yl)isoindolin-i-one 465) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i-(methylsulfonyl)-i,2,3,6-tetrahydropyri din-4-yl)isoindolin-i-one 466) 4-(i-acetyl-i,2,3,6-tetrahydropyridin-4-yl)-2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)isoindolin-i-one 467) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)-5,6-dihydropyridine-i(2H)-carboxamide 468) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,i-dioxido-3,6-dihydro-2H-thiopyran-4-yl)isoindolin-i-one 469) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 470) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinonitrile 471) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(3-(hydroxymethyl)pyridin-4-yl)isoindolin-i-one 472) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(hydroxymethyl)pyridin-4-yl)isoindolin-i-one 473) 4-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 474) 5-(2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-i-oxoisoindolin-4-yl)picolinamide 475) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyri din-4-yl)isoindolin-i-one 476) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 477) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-methylpyridin-3-yl)isoindolin-i-one 478) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)isoindolin-i-one 479) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)isoindolin-i-one 480) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(pyri din-4-yl)isoindolin-i-one 481) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-methoxypyridin-4-yl)isoindolin-i-one 482) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-(methylamino)pyridin-4-yl)isoindolin-i-one 483) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-(dimethylamino)pyridin-4-yl)-7-fluoroisoindolin-i-one484) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-fluoropyridin-3-yl)isoindolin-i-one 485) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(2-fluoropyri din-4 -yl)isoindolin-i-one 486) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(5-methylpyridin-3-yl)isoindolin-i-one 487) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-fluoro-4-(3-methylpyridin-4-yl)isoindolin-i-one 488) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2,6-dimethylpyridin-4-yl)-7-fluoroisoindolin-i-one 489) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-nitro-4-(pyridin-4-yl)isoindolin-i-one 490) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(dimethylamino)-4-(pyri din-4-yl)isoindolin-i-one 491) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(methylamino)-4-(pyridin-4-yl)isoindolin-i-one 492) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-iodo-4-phenylisoindolin-i-one 493) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-phenyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyri din-7-one 494) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 495) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimi din-4-yl)-iH-indol-7-yl)-4-(pyridin-3-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 496) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(i,2,3,6-tetrahydropyri din-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 497) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(pyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 498) 6-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-3-(i,2,3,6-tetrahydropyridin-4-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one 499) 2-(3-(2-((i,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(i,2,3,6-tetrahydropyri din-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 500) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-7-(pyridin-4-yl)-i,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 501) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(pyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 502) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one503) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(5-fluoropyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 504) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4-yl)-iH-indol-7-yl)-4-(2-fluoropyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 505) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-4-(5-methylpyridin-3-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one 506) 2-(3-(2-((1,5-dimethyl-iH-pyrazol-3-yl)amino)-5-methylpyrimidin-4- yl)-iH-indol-7-yl)-4-(3-methylpyridin-4-yl)-2,3-dihydro-iH-pyrrolo[3,4-c]pyridin-i-one6. A pharmaceutical composition comprising the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to any one of claims 1 to 5 as an active ingredient.

7. The pharmaceutical composition according to claim 6, wherein the pharmaceutical composition is used for preventing or treating GCN2 activation-related diseases.

8. The pharmaceutical composition according to claim 6, wherein the composition further comprises one or more therapeutic agent selected from the group consisting of chemotherapy agent, radiotherapy agent, immunotherapy agent and tumor microenvironment modulating agent.

9. A method for preventing or treating GCN2 activation-related diseases, comprising administering a therapeutically effective amount of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to any one of claims 1 to 5 into a subject.

10. The method according to claim 9, wherein the GCN2 activation-related diseases comprise a cancer, a neurodegenerative disease, a chronic infection and a metabolic disease.ii. The method according to claim 10, wherein the cancer is one more selected from the group consisting of thyroid cancer, melanoma, prostate cancer, endometrial cancer, lung cancer, head and neck cancer, pancreatic cancer, glioma, stomach cancer, urothelial cancer, skin cancer, breast cancer, colorectal cancer, renal cancer, fibrosarcoma, bone sarcoma, connective tissue sarcoma, giant cell carcinoma, squamous cell carcinoma, leukemia, skin cancer, soft tissue cancer, liver cancer, adenocarcinoma, hepatocellular carcinoma, multiple myeloma, myelodysplastic syndrome, myeloproliferative neoplasm, malignant glioma, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, Burkitt’s lymphoma, chronic lymphocytic leukemia, chronic myeloid leukemia, hairy cell leukemia, plasmacytoma, lymphoplasmacytic lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, large granular lymphocytic leukemia, B-cell prolymphocytic leukemia, T-cell prolymphocytic leukemia, small cell lung cancer and pediatric neuroblastoma.

12. A method for inhibiting GCN2 activity, comprising administering a therapeutically effective amount of the compound, the tautomer thereof, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to any one of claims i to 5 into a subject.

13. Use of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to any one of claims 1 to 5 for preventing or treating GCN2 activation-related diseases.

14. Use of the compound, the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the solvate thereof according to any one of claims 1 to 5 in the manufacture of a medicament for preventing or treating GCN2 activation-related diseases.