Compositions and methods for treating bile acid malabsorption
The formulation of a high drug load, gastro-resistant tablet core for bile acid sequestrants addresses compliance and adverse effects by targeting bile acids in the ileum and colon, improving treatment efficacy and reducing interactions.
Patent Information
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- COSMO TECHNOLOGIES LTD
- Filing Date
- 2025-01-31
- Publication Date
- 2026-07-16
AI Technical Summary
Current bile acid sequestrants for treating bile acid malabsorption and diarrhea have low patient compliance due to high doses, adverse reactions, and unwanted interactions with the upper gastrointestinal tract, leading to nutritional deficiencies and drug interactions.
A pharmaceutical composition with a high drug load, formulated as a tablet core with a gastro-resistant coating for delayed release in the ileum and colon, minimizing adverse effects and interactions by targeting bile acids in the lower gastrointestinal tract.
Enhances patient compliance by reducing the number of administrations and minimizing adverse effects, while maintaining the therapeutic efficacy of bile acid sequestration in the ileum and colon, thus addressing the limitations of existing formulations.
Smart Images
Figure 00000155_0000