Application device and analyte monitoring system

Abstract

Provided are an application device (100) and an analyte monitoring system (1000). The application device (100) comprises a first housing (10), a second housing (30), a drive mechanism (50), a moving body (20), and a piercing member (40) disposed on the moving body, as well as a proximal end close to a host and a distal end away from the host during operation. The first housing and the second housing relatively move toward each other to release a restriction on the moving body. After being released, the moving body and the piercing member move toward the proximal end under the action of the drive mechanism to apply a monitoring device (800) to the host, with at least a portion of the monitoring device being located subcutaneously in the host.

Description

Application devices and analyte monitoring systems Technical Field

[0001] The present disclosure relates generally to the field of medical devices, and more particularly to an application device and an analyte monitoring system. Background Art

[0002] Currently, the main methods for diabetic patients to monitor their blood glucose levels include traditional fingerstick blood tests (Blood Glucose Monitoring, BGM) and continuous glucose monitoring systems (CGMS). CGMS can monitor a patient's blood glucose level in real time and has the ability to detect hidden hyperglycemia and hypoglycemia that are difficult to detect with traditional fingerstick blood tests, making it a new trend in blood glucose monitoring.

[0003] CGMS typically uses a glucose sensor that can be inserted below the skin and react with glucose in the interstitial fluid, and an electronic device that is applied to the skin and connected to the glucose sensor to monitor the glucose concentration in the interstitial fluid. Inserting the glucose sensor below the skin and applying the electronic device to the skin typically require the use of an insertion device. Specifically, the insertion device can include a needle that can penetrate the skin, through which the glucose sensor is inserted below the skin, and then the needle is separated from the glucose sensor and removed from the skin.

[0004] However, in the aforementioned prior art, the needle insertion and removal process typically requires manual effort. In this case, precise control of the needle's force, the location of the needle's insertion, the depth of the needle's insertion, and the timing of its removal can be difficult. This can affect the user's experience when inserting the glucose sensor and may also result in inaccurate glucose concentrations if the glucose sensor is not inserted in the desired position. Summary of the Invention

[0005] The present disclosure is made in view of the above-mentioned state of the prior art, and its object is to provide an application device and an analyte monitoring system that are easy to operate and can accurately apply the monitoring device to a host.

[0006] To this end, the present disclosure provides an application device, which is an application device for applying a monitoring device to a host, the application device comprising a first shell, a second shell, a driving mechanism, a moving body, a puncture member arranged on the moving body, and a proximal end close to the host and a distal end away from the host during operation, the first shell comprising a first retaining portion for releasably retaining the moving body, the second shell having a proximal surface for contacting the host's skin during operation, the moving body comprising a storage portion for accommodating the monitoring device, the puncture member being configured to at least partially introduce the monitoring device into the subcutaneous tissue of the host, the first shell and the second shell moving relative to each other in a manner close to each other to release the retention of the moving body by the first retaining portion, and after being released, the moving body moves toward the proximal end together with the puncture member under the action of the driving mechanism so that the monitoring device is applied to the host and is at least partially located under the subcutaneous tissue of the host.

[0007] In the present disclosure, an application device includes a moving body for accommodating a monitoring device, a puncture member capable of at least partially introducing the monitoring device into the subcutaneous tissue of a host, a first shell for releasably holding the moving body, and a second shell capable of cooperating with the first shell to release the locking of the moving body by the first shell (even if the first retaining portion releases the moving body, this action can be referred to as unlocking). After unlocking, the moving body and the puncture member can be moved toward the proximal end close to the host under the action of a driving mechanism to apply the monitoring device to the body surface of the host, and the puncture member can at least partially introduce the monitoring device into the subcutaneous tissue of the host. In this case, by placing the proximal surface of the second shell on the skin of the host, on the one hand, it is convenient to apply force to make the two shells (the first shell and the second shell) move relative to each other to unlock the moving body, and on the other hand, it is helpful to limit the application position, and the driving mechanism can provide a relatively accurate driving action, so that the puncture force and puncture depth of the puncture member during the application process can be more accurately controlled, thereby facilitating the accurate application of the monitoring device to the host.

[0008] In addition, according to the application device involved in the present disclosure, optionally, the movable body includes a first locking portion configured to releasably interlock with the first retaining portion, and the second housing includes a first triggering portion that can separate the first retaining portion from the first locking portion to release the movable body. Thus, the movable body can be releasably retained in the first retaining portion through the cooperation of the first locking portion and the first retaining portion, and the first triggering portion can facilitate the release of the movable body through relative movement of the two housings.

[0009] Furthermore, according to the application device of the present disclosure, optionally, when the first housing and the second housing move relative to each other along the central axis of the application device, the first triggering portion acts on the first locking portion to separate the first locking portion from the first retaining portion. In this case, the first locking portion can be separated from the first retaining portion by the first triggering portion simply by moving the two housings relative to each other along the central axis, which can facilitate use by an operator.

[0010] In addition, according to the application device involved in the present disclosure, optionally, the first retaining portion is a convex structure formed on the inner wall of the first shell, and when the moving body is retained by the first retaining portion, the first locking portion engages with the convex structure; the first trigger portion deflects the first locking portion in a direction away from the first retaining portion to separate the first locking portion from the first retaining portion. In this case, compared to providing a first retaining portion of a certain length that can be deflected inside the first shell, providing the first retaining portion as a convex structure formed on the inner wall of the first shell can reduce the space required for providing the first retaining portion while reducing the difficulty of the manufacturing process of the first shell, thereby contributing to the miniaturization of the application device and facilitating its use by the operator.

[0011] Furthermore, according to the application device of the present disclosure, optionally, the first housing includes a first restricting portion configured to inhibit the second housing from detaching from the first housing, the second housing includes a first restricting portion, and the first restricting portion is coupled to the first restricting portion. In this case, the second housing can be restrained by the first housing through the cooperation of the first restricting portion and the first restricting portion, and inhibiting the second housing from detaching from the first housing can help improve the reliability of the application device.

[0012] In addition, according to the application device of the present disclosure, optionally, the first housing includes a second limiting portion configured to inhibit movement of the second housing toward the proximal end. After the first and second housings move relative to each other and release the moving body, the second housing is constrained by the second limiting portion. In this case, the second limiting portion can limit movement of the second housing toward the proximal end, thereby preventing an operator from reusing the application device and reducing the risk of a used, non-secondarily sterilized puncture member coming into contact with the host.

[0013] In addition, according to the application device of the present disclosure, optionally, the first limiting portion and the second limiting portion are disposed adjacent to each other along a central axis of the application device, and the first limiting portion is configured to cooperate with the second limiting portion to retain the second housing. This can help simplify the structure of the application device.

[0014] In addition, according to the application device involved in the present disclosure, optionally, the drive mechanism includes a first drive unit and a second drive unit, and the moving body includes a second retaining unit that releasably retains the puncture member. After the moving body and the puncture member move toward the proximal end to a predetermined position under the action of the first drive unit, the second retaining unit releases the puncture member, and the puncture member moves toward the distal end under the action of the second drive unit. In this case, the first drive unit and the second drive unit perform the application and withdrawal operations respectively, which can more accurately control the puncture force, puncture depth, and timing of the puncture member leaving the host.

[0015] In addition, according to the application device involved in the present disclosure, optionally, the first driving part is an elastic element, and the two ends of the first driving part respectively abut the first housing and the moving body. When the moving body is retained by the first retaining part, the first driving part is in a compressed state. In this case, when the moving body is released, the compressed first driving part can automatically apply force to the moving body to achieve automatic pushing, which is convenient for the operator.

[0016] In addition, according to the application device involved in the present disclosure, optionally, the second driving portion is an elastic element, and the two ends of the second driving portion respectively abut the moving body and the piercing member. When the piercing member is retained by the second retaining portion, the second driving portion is in a compressed state. In this case, when the piercing member is released, the compressed second driving portion can automatically apply a force to the piercing member to achieve automatic retraction of the piercing member, facilitating operation by the operator.

[0017] In addition, according to the application device involved in the present disclosure, optionally, the application device includes an applicator cover, which is detachably assembled to the first shell. When the applicator cover is assembled to the first shell, the second shell is located in a sealed accommodation space formed by the applicator cover and the first shell. In this case, the cooperation between the applicator cover and the first shell can form a sealed space to protect the internal structure, and the location of the second shell in the sealed space can suppress the occurrence of unexpected accidental touches, thereby improving the reliability of the application device.

[0018] In addition, according to the application device involved in the present disclosure, optionally, the monitoring device includes a sensor that can be partially placed under the host's skin, an electronic component coupled to the sensor, and a sealing component that seals the sensor, the applicator cover is coupled to the sealing component, and when the applicator cover is removed from the first housing, the sealing component is removed along with the applicator cover to put the application device into an application-ready state. In this case, the sealing component that seals the sensor can help maintain the sterility of the sensor for a long time, and the applicator cover is coupled to the sealing component and can be removed simultaneously when the applicator cover is removed, which can facilitate use by the operator.

[0019] In addition, according to the application device involved in the present disclosure, optionally, the sealing assembly has a first engagement feature, and the applicator cover includes a second engagement feature, and the first engagement feature cooperates with the second engagement feature so that when the applicator cover is rotated in a first direction, the sealing assembly rotates with the applicator cover, and when the applicator cover is rotated in a second direction opposite to the first direction, the sealing assembly remains stationary. In this case, the sealing assembly can be removed while the applicator cover is being removed by rotating the applicator cover in the first direction, thereby facilitating use; and during the assembly process of rotating the applicator cover in the second direction opposite to the first direction to assemble the applicator cover to the first housing, the sealing state of the sealing assembly will not be affected, thereby facilitating factory assembly of the application device and the monitoring device.

[0020] A second aspect of the present disclosure provides an analyte monitoring system, comprising the application device described in the first aspect of the present disclosure and a monitoring device, thereby providing an analyte monitoring system that is easy to operate and can accurately apply the monitoring device to a host.

[0021] According to the present disclosure, an application device and an analyte monitoring system can be provided that are easy to operate and can accurately apply the monitoring device to a host. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Embodiments of the present disclosure will now be explained in further detail, by way of example only, with reference to the accompanying drawings.

[0023] FIG1 is a schematic diagram showing an application scenario of a monitoring device involved in an example of the present disclosure.

[0024] FIG2 is a schematic diagram showing a monitoring device according to an example of the present disclosure.

[0025] FIG3 is a schematic diagram showing a sensor according to an example of the present disclosure.

[0026] FIG. 4 is a schematic diagram illustrating a sterilization assembly according to an example of the present disclosure.

[0027] FIG. 5 is an exploded view illustrating a sterilization assembly according to an example of the present disclosure.

[0028] FIG. 6A is a schematic diagram showing a sterilization component and an electronic component before being assembled according to an example of the present disclosure.

[0029] FIG6B is a schematic diagram showing the assembly of the sterilization component and the electronic component according to an example of the present disclosure.

[0030] FIG. 7 is a schematic diagram showing the overall appearance of an application device according to an example of the present disclosure.

[0031] FIG8 is a cross-sectional view showing an application device according to an example of the present disclosure.

[0032] FIG. 9 is an exploded view showing an application device according to an example of the present disclosure.

[0033] FIG. 10 is a schematic diagram illustrating a first housing according to an example of the present disclosure.

[0034] FIG. 11 is a schematic diagram illustrating a second housing according to an example of the present disclosure.

[0035] FIG. 12 is a schematic diagram illustrating a moving subject according to an example of the present disclosure.

[0036] FIG13 is a cross-sectional view showing the assembled first shell, second shell and moving body involved in the example of the present disclosure.

[0037] FIG. 14 is a cross-sectional view showing the first locking portion before being triggered by the first triggering portion according to an example of the present disclosure.

[0038] FIG. 15 is a cross-sectional view showing the first locking portion according to an example of the present disclosure after being triggered by the first triggering portion.

[0039] FIG. 16 is a schematic cross-sectional view showing that the first restricting portion according to the example of the present disclosure is not engaged with the second restricting portion.

[0040] FIG. 17 is a schematic cross-sectional view showing engagement between a first restricting portion and a second restricting portion according to an example of the present disclosure.

[0041] FIG18 is an exploded schematic diagram showing a first perspective of the moving body and the piercing member involved in an example of the present disclosure.

[0042] FIG. 19 is an exploded schematic diagram showing a second perspective of the moving body and the piercing member according to an example of the present disclosure.

[0043] FIG. 20 is a schematic cross-sectional view showing a state where the puncture member according to an example of the present disclosure is retained.

[0044] FIG. 21 is a schematic diagram illustrating a seal assembly and an applicator cap according to an example of the present disclosure.

[0045] FIG. 22 is a schematic structural diagram showing an inclined groove according to an example of the present disclosure. DETAILED DESCRIPTION

[0046] The preferred embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. In the following description, identical components are assigned identical reference numerals, and duplicate descriptions are omitted. In addition, the accompanying drawings are merely schematic, and the proportions of the dimensions of the components and the shapes of the components may differ from the actual ones.

[0047] It should be noted that the terms "including" and "having" and any variations thereof in this disclosure, such as a process, method, system, product or device that includes or has a series of steps or units, are not necessarily limited to those steps or units clearly listed, but may include or have other steps or units that are not clearly listed or are inherent to these processes, methods, products or devices.

[0048] The present disclosure relates to an application device that can be used to apply a monitoring device to a host, such as applying the monitoring device to the host's body surface or placing the monitoring device completely or partially subcutaneously. The application device of this embodiment can facilitate application of the monitoring device to a desired location. In the present disclosure, the monitoring device can be used to monitor physiological parameters of the host. The monitoring device can also be other medical devices that need to be applied to the host.

[0049] The application device involved in this embodiment may also be called an insertion device, a pushing device, a boosting device, a transport device, an implantation device, an application device, or an auxiliary device, etc. It should be noted that each name is used to indicate the device involved in this embodiment for applying the monitoring device to the host and should not be understood as limiting.

[0050] In addition, the present disclosure also provides an analyte monitoring system. The analyte monitoring system of the present disclosure may include a monitoring device and an application device. The monitoring device can be used to obtain physiological parameter information of a host. The monitoring device can be applied to the host by the application device, and the host's physiological parameter information can be monitored by the monitoring device. In the present disclosure, the analyte monitoring system may also be referred to as an analyte monitoring kit, an analyte combination kit, or a monitoring system.

[0051] Hereinafter, the application device and analyte monitoring system involved in the present disclosure will be described with reference to the accompanying drawings.

[0052] FIG1 is a diagram showing an application scenario of a monitoring device 800 involved in an example of the present disclosure.

[0053] In some examples, the monitoring device 800 can be applied to the host via the application device 100 and applied to a desired location, and the host can obtain physiological parameter information (which may be simply referred to as physiological information) through the monitoring device 800 applied to itself.

[0054] In some examples, analyte monitoring system 1000 can include monitoring device 800 and application device 100 (see FIG1 ). Monitoring device 800 can be used to obtain physiological parameter information of a host. Monitoring device 800 can be applied to a host via application device 100, and the host's physiological parameter information can be monitored via monitoring device 800.

[0055] In some examples, the analyte monitoring system 1000 may further include a reader device 900 (see FIG1 ) communicatively coupled to the monitoring apparatus 800. The monitoring apparatus 800 applied to the host may transmit acquired physiological parameter information to the reader device 900, for example, wirelessly, thereby facilitating the host to read and monitor its own physiological parameter information.

[0056] In some examples, monitoring device 800 may be an analyte sensor device that can generate information about a specific analyte in a body fluid based on the body fluid, such as by reacting with the analyte in the body fluid and generating the analyte information. In this case, sensor 8 reacts with the analyte in the body fluid, thereby facilitating acquisition of the analyte information in the body fluid.

[0057] In some examples, the analyte can be one or more of glucose, acetylcholine, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase, creatine, creatinine, DNA, fructosamine, glucose, glutamine, growth hormone, ketone bodies, lactate, oxygen, peroxide, prostate-specific antigen, prothrombin, RNA, thyroid-stimulating hormone, or troponin.

[0058] To facilitate understanding, the monitoring device 800 of the present disclosure will be described below. The monitoring device 800 of this embodiment will be described below using glucose as an example analyte. It should be noted that, for other analytes, those skilled in the art can analyze other analytes by making minor modifications to the monitoring device 800 used for glucose.

[0059] Fig. 2 is a schematic diagram showing a monitoring device 800 according to an example of the present disclosure. Fig. 3 is a schematic diagram showing a sensor 8 according to an example of the present disclosure.

[0060] In some examples, the monitoring device 800 may include a sensor 8 and an electronic component 9 (see Figure 2). The sensor 8 may be assembled to the electronic component 9. In order to facilitate the reaction with tissue fluids such as body fluids, the sensor 8 may be partially or completely placed under the host's skin. After being placed under the skin, the sensor 8 may react with the glucose in the subcutaneous tissue fluid to generate glucose information of the host. The electronic component 9 may be applied to the host's body surface. The electronic component 9 may be electrically connected to the sensor 8 and receive the glucose information generated by the sensor 8. In addition, the electronic component 9 may also provide the sensor 8 with the electrical energy required to obtain physiological information. This can facilitate the sensor 8 to perform continuous monitoring under the host's skin.

[0061] In some examples, the sensor 8 may include an implant portion 81 and a connection portion 82 (see FIG3 ). The implant portion 81 may be placed subcutaneously in the host and connected to the electronic assembly 9 via the connection portion 82. In this case, by placing the implant portion 81 subcutaneously in the host and connecting the implant portion 81 to the electronic assembly 9 via the connection portion 82, the sensor 8 may be temporarily fixed to a specific location in the host.

[0062] In some examples, implant portion 81 may include a working electrode and a counter electrode. In this embodiment, a sensing layer including glucase may be provided on the working electrode. Subcutaneously placed sensor 8 can generate a current signal through a redox reaction between the glucase on the working electrode and glucose in tissue fluid or blood, forming a circuit with the counter electrode. This current signal is then analyzed and processed to obtain glucose concentration information. The current signal generated by sensor 8 can be transmitted to electronic component 9.

[0063] In some examples, the implant portion 81 may further include a reference electrode. The reference electrode may form a known and fixed potential difference with the tissue fluid or blood. In this case, the potential difference between the working electrode and the tissue fluid or blood may be measured based on the potential difference formed between the reference electrode and the working electrode. Thus, the voltage generated by the working electrode can be obtained more accurately. In addition, in this case, the electronic component 9 may automatically adjust and maintain the stability of the voltage at the working electrode according to a preset voltage value, so that the measured current signal can more accurately reflect the glucose concentration information in the tissue fluid or blood. In some examples, the number of reference electrodes may be one or more, for example, two.

[0064] In some examples, the electronic assembly 9 may include a housing 91 (see FIG2 ). In some examples, the electronic assembly 9 may include electronic components disposed within the housing 91. In some examples, the electronic components may include a power module, a switch module, and a processing module. The power module may provide power to the sensor 8 and / or the processing module, the switch module may control the connection between the power module and the sensor 8 and / or the processing module, and the processing module may process the signal (e.g., glucose information) generated by the sensor 8.

[0065] In some examples, the electronic device may have an initial mode configured as an open circuit and an operating mode configured as a closed circuit. In this case, when the electronic device is in the initial mode, it is configured as an open circuit, thereby saving power consumption before the electronic device enters the operating state. In some examples, when the electronic device is configured in the initial mode, the switch module may be in an open state, and when the electronic device is configured in the operating mode, the switch module may be in a closed state. In other words, the electronic device can be switched from the initial mode to the operating mode via the switch module. In this case, the switching of the electronic device from the initial mode to the operating mode is controlled by the switch module, thereby effectively reducing the power consumption of the electronic device before it enters the operating state.

[0066] In some examples, the electronic component 9 can be configured to be excited from the initial mode to the operating mode by magnetic or optical action. In this case, the electronic component 9 is excited from the initial mode to the operating mode by non-contact means such as magnetic or optical action, thereby facilitating miniaturization of the electronic component 9.

[0067] In some examples, the application device 100 (described later) may include a magnet. In some examples, when the monitoring device 800 has not yet been applied to the host, the electronic component 9 of the monitoring device 800 is close to the magnet at this time, and the switch module of the electronic component 9 can be in an open state. In some examples, when the monitoring device 800 is applied to the host, the electronic component 9 of the monitoring device 800 is away from the magnet at this time, and the switch module of the electronic component 9 can be stimulated to a closed state. In this case, in the standby state before the analyte monitoring system 1000 is used after leaving the factory, the monitoring device 800 is located in the application device 100. At this time, the monitoring device 800 can be in an initial mode of low power consumption or zero power consumption, which helps to extend the standby life (also known as shelf life) of the monitoring device 800.

[0068] In some examples, when the monitoring device 800 is applied to the host and the application device 100 has not yet left the host, the switch module of the electronic component 9 can be in the open state because the electronic component 9 of the monitoring device 800 is close to the magnet. In some examples, when the monitoring device 800 is applied to the host and the application device 100 has left the host, the switch module of the electronic component 9 can be activated to the closed state because the electronic component 9 of the monitoring device 800 is far away from the magnet.

[0069] FIG4 is a schematic diagram illustrating a sterilization assembly 92 according to an example of the present disclosure. FIG5 is an exploded view illustrating a sterilization assembly 92 according to an example of the present disclosure. FIG6A is a schematic diagram illustrating the sterilization assembly 92 according to an example of the present disclosure before being assembled with the electronic assembly 9. FIG6B is a schematic diagram illustrating the sterilization assembly 92 according to an example of the present disclosure after being assembled with the electronic assembly 9. In FIG5 and FIG6A, line JK schematically represents the central axis of the sterilization assembly 92.

[0070] In some examples, the sensor 8 can be sealed first, the sterilization assembly 92 containing the sensor 8 can be sterilized, and then the sterilization assembly 92 can be assembled with the electronic assembly 9 and then assembled with the application device 100. In this case, compared to the prior art solution that requires the sensor 8 and electronic assembly 9 to be sterilized separately, and the operator needs to use the application device 100 containing the electronic assembly 9 to pick up and assemble the sensor 8 located in another container before use to form a complete monitoring device 800, the application device 100 of the present disclosure can accommodate the complete monitoring device 800, and the operator does not need to perform additional picking and assembly operations before use, which can facilitate the operator's use.

[0071] In the present disclosure, sealing the sensor 8 includes multiple implementations. Hereinafter, one embodiment of sealing the sensor 8 will be introduced, but the specific structure is not limited thereto.

[0072] In some examples, monitoring device 800 may include a sealing assembly 93 (see FIG. 4 ). Sealing assembly 93 may be used to seal sensor 8. Specifically, sealing assembly 93 may seal implantable portion 81 of sensor 8. In this case, sealing assembly 93 with sensor 8 may help maintain the sterility of sensor 8 for a long period of time, thereby increasing the shelf life of monitoring device 800 (the shelf life refers to the period from the time monitoring device 800 is sterilized and assembled and shipped to the time it is used by an operator, also known as shelf life).

[0073] In some examples, the sensor 8 can be sterilized so that the sensor 8 remains in the sealing assembly 93, and then the sensor 8 and the sealing assembly 93 are assembled to the electronic assembly 9 to form the monitoring device 800, and then the monitoring device 800 is installed in the application device 100. In other words, the sealing assembly 93 can be used as a part of the sterilization assembly 92. Before using the application device 100 to apply the monitoring device 800 to the host, the sealing assembly 93 can be removed first to make the monitoring device 800 ready for application. In this case, compared with the solution in the prior art that requires the sensor 8 and the electronic assembly 9 to be packaged separately for sterilization, and the operator needs to pick up the sensor 8 located in other containers before use and assemble it with the electronic assembly 9 to form a complete monitoring device 800, the application device 100 of the present disclosure can accommodate the complete monitoring device 800, and the operator does not need to perform additional picking and assembly actions before use. It can be convenient for the operator to use.

[0074] In some examples, the monitoring device 800 may include a mounting base 94 (see Figure 4). The sensor 8 can be assembled with the electronic component 9 through the mounting base 94. In some examples, the mounting base 94 may have a first through hole 941 (see Figure 5). The first through hole 941 can serve as a channel for the sensor 8 to extend outward. In some examples, one end of the sensor 8 can pass through the side wall of the mounting base 94. Specifically, the connecting portion 82 of the sensor 8 can pass through the side wall of the mounting base 94. In some examples, the electronic component 9 may include an electrical connection base. After the sensor 8 is assembled with the electronic component 9 through the mounting base 94, the sensor 8 can be electrically connected to the electronic devices inside the electronic component 9 through the electrical connection base.

[0075] In some examples, the sealing assembly 93 can cooperate with the mounting seat 94 to seal the sensor 8. Specifically, the implant portion 81 of the sensor 8 can extend beyond the mounting seat 94, and the sealing assembly 93 can abut against the mounting seat 94 and surround the outer periphery of the implant portion 81 of the sensor 8 extending beyond the mounting seat 94. In other words, the sealing assembly 93 can seal one end of the first through hole 941.

[0076] In some examples, the application device 100 may include a puncture member 40 (see Figures 4 and 5). The puncture member 40 can be configured to at least partially introduce the monitoring device 800 into the host's subcutaneous tissue. For example, the puncture member 40 can introduce the implanted portion 81 of the sensor 8 into the host's subcutaneous tissue. In some examples, the puncture member 40 may include a needle-shaped portion 41 and a supporting portion 42 connected to the needle-shaped portion 41 (see Figure 5). The needle-shaped portion 41 can accommodate the sensor 8. In some examples, the sealing assembly 93, the mounting seat 94 and the puncture member 40 can cooperate to seal the sensor 8 (the specific structure of the puncture member 40 will be described in detail later, and the content related to sealing the sensor 8 is mainly introduced here). Specifically, the first through-hole 941 of the mounting seat 94 can serve as a passage for the puncture member 40 to pass downward. The bearing portion 42 of the puncture member 40 abuts the upper surface of the mounting seat 94, sealing the upper end of the first through-hole 941. The needle portion 41 passes through the first through-hole 941 and downward to accommodate the implant portion 81 of the sensor 8. The sealing assembly 93 surrounds the outer periphery of the needle portion 41 and the portion of the sensor 8 that passes through the mounting seat 94. At this time, the puncture member 40 and the sealing assembly 93 respectively seal the ends of the first through-hole 941, thereby sealing the sensor 8 in the sealed space formed by the puncture member 40, the mounting seat 94, and the sealing assembly 93. In some examples, the bearing portion 42 can also pass downward from the first through-hole 941, and the sealing assembly 93 can be detachably connected to the bearing portion 42.

[0077] In some examples, the sterilization assembly 92 may further include a seal. For example, the sterilization assembly 92 may include a first seal 951 and a second seal 952 (see FIG5 ). The first seal 951 may be positioned between the support portion 42 and the upper surface of the mounting seat 94 , thereby improving the sealing performance of the sterilization assembly 92 . The second seal 952 may be positioned between the sealing assembly 93 and the lower surface of the mounting seat 94 , thereby improving the sealing performance of the sterilization assembly 92 .

[0078] In some examples, the sterilization assembly 92 including the mounting base 94, the sealing assembly 93, the piercing member 40, and the sensor 8 can be sterilized, and then assembled to the electronic assembly 9 and then assembled with the application device 100. Referring to FIG6A , the sterilization assembly 92 can be assembled to the electronic assembly 9 along the direction D1 to form an assembly including the monitoring device 800 that can be mounted to the application device 100 as shown in FIG6B .

[0079] In the present disclosure, sealing the sensor 8 may also include other variations. For example, in some examples, the housing 91 of the electronic assembly 9 may include an upper housing 911 and a lower housing 912 (see FIG2 ). The electronic device may be disposed in a housing space formed by the upper housing 911 and the lower housing 912. In some examples, the mounting base 94 may be the upper housing 911 or the lower housing 912 of the electronic assembly 9, and may cooperate with the sealing assembly 93 and the puncture member 40 to seal the sensor 8. The specific structure can be obtained by slightly modifying the above-mentioned mounting base 94, and will not be described in detail here.

[0080] In some examples, the electronic component 9 can be adhered to the host's body surface. For example, the monitoring device 800 can further include an adhesive sheet disposed at the bottom of the housing 91 of the electronic component 9 and having adhesive properties. The electronic component 9 can be adhered to the host's body surface via the adhesive sheet.

[0081] In some examples, the electronic assembly 9 can be configured to communicate with an external device via wireless or wired communication. In this case, by configuring the electronic assembly 9 to communicate with the external device, the analyte information acquired by the sensor 8 can be read in real time or on a scheduled basis. The external device can be a reader 900.

[0082] In some examples, monitoring device 800 can be communicatively connected to reader device 900. In some examples, reader device 900 can be a display with communication capabilities. In some examples, the communication capabilities of reader device 900 can be implemented via wireless or wired communication. Wireless communication methods can include Bluetooth, NFC, Wi-Fi, etc. Wired communication methods can include USB, fiber optics, etc. Alternatively, reader device 900 can be a smart terminal installed with an application compatible with monitoring device 800. The smart terminal can be a laptop, tablet, smartphone, etc.

[0083] As described above, the monitoring device 800 of the present disclosure can be applied to the host through the application device 100. Hereinafter, the application device 100 of the present disclosure will be described in detail with reference to the accompanying drawings.

[0084] FIG7 is a schematic diagram illustrating the overall appearance of an application device 100 according to an example of the present disclosure. FIG8 is a cross-sectional view illustrating an application device 100 according to an example of the present disclosure. FIG9 is an exploded view illustrating an application device 100 according to an example of the present disclosure. In FIG8 and FIG9 , line CA schematically represents the central axis CA of the application device 100. Subsequent references to "central axis CA" refer to the central axis CA of the application device 100.

[0085] In some examples, the application device 100 may include a first shell 10 that can provide a moving space, and a moving body 20 (see Figures 7, 8, and 9 in combination). The moving body 20 can accommodate the monitoring device 800 and is configured to be movable within the moving space of the first shell 10. In some examples, the application device 100 may have a proximal end 101 that is close to the host during operation and a distal end 102 that is away from the host (see Figure 8). It will be understood that, in this article, the "proximal end 101" can be understood as the end that is close to the host during operation, and the "distal end 102" can be understood as the end that is away from the host during operation.

[0086] In some examples, the moving body 20 may be releasably retained in the first housing 10. When the moving body 20 is released, it may move within the moving space of the first housing 10.

[0087] In some examples, the application device 100 may include a second housing 30 (see FIG. 8 or 9 ). The second housing 30 may be movable relative to the first housing 10. In some examples, the second housing 30 may be at least partially located within the accommodation space of the first housing 10. In some examples, a movable space may be formed after the first housing 10 and the second housing 30 are assembled and combined. The moving body 20 may move within the movable space formed after the first housing 10 and the second housing 30 are assembled and combined.

[0088] In some examples, the second housing 30 can limit the movement path of the moving body 20. That is, when the moving body 20 is released, it can move along the movement path defined by the second housing 30. In some examples, the axis of the first housing 10 and the axis of the second housing 30 can be substantially parallel to the central axis CA of the application device 100. In some examples, the first housing 10 and the second housing 30 can be coaxially arranged. For example, in FIG8 , the axis of the first housing 10 and the second housing 30 can overlap with the central axis CA of the application device 100.

[0089] In some examples, the second shell 30 and the first shell 10 can move relative to each other to release the moving body 20. In this case, the lock on the moving body 20 can be released by the cooperation of the two shells, which can facilitate the operator's use. In some examples, the second shell 30 can define the application position of the monitoring device 800 on the host's body surface. In some examples, the second shell 30 can have a proximal surface 31 that contacts the host's skin during operation (see Figure 9). In this case, by placing the proximal surface 31 of the second shell 30 on the host's skin, on the one hand, it can facilitate the application of force to cause the first shell 10 and the second shell 30 to move relative to each other (hereinafter referred to as the relative movement of the two shells) to unlock the moving body 20, and on the other hand, it also helps to define the application position, which is conducive to accurately applying the monitoring device 800 to the host. Moreover, the application device 100 of the present disclosure can place the proximal surface 31 of the second shell 30 on the host's skin to apply force. Compared with the application device with a trigger button set on the shell, the force application area is larger, and the linkage triggering of the two shells can make it more convenient for the operator to use.

[0090] In some examples, the motion body 20 may include a housing 21 (see FIG. 9 ). The housing 21 may be used to accommodate the monitoring device 800. In some examples, the monitoring device 800 may be releasably retained in the housing 21. In this case, the monitoring device 800 can be moved together by driving the motion body 20. After the monitoring device 800 is applied to the host, it can be detached from the housing 21 to remain in the host for monitoring.

[0091] In some examples, the monitoring device 800 applied to the host can be released from the support of the moving body 20 and remain on the host. Thus, the monitoring device 800 applied to the host can monitor the host's physiological parameters. In some examples, the monitoring device 800 applied to the host can adhere to the host's body surface. When the operator removes the application device 100 from the host's body surface, the monitoring device 800 can adhere to the host's body surface and be released from the receiving portion 21.

[0092] In some examples, as described above, the application device 100 may include a puncture member 40 (see FIG. 8 or FIG. 9 ). The puncture member 40 may partially introduce the monitoring device 800 into the host's subcutaneous tissue. In some examples, the puncture member 40 may be disposed on the movable body 20. When the movable body 20 is released and allowed to move toward the proximal end 101, the puncture member 40 and the receiving portion 21 disposed on the movable body 20 also move toward the proximal end 101 to apply the monitoring device 800 contained within the receiving portion 21 to the host. The puncture member 40 may at least partially place the monitoring device 800 under the host's subcutaneous tissue.

[0093] In some examples, the piercing member 40 may be releasably mounted on the moving body 20. When released, the piercing member 40 may move relative to the moving body 20. For example, when released, the piercing member 40 may move relative to the moving body 20 in a direction away from the host. This allows the piercing member 40 to be removed from the host.

[0094] In some examples, the application device 100 may include a drive mechanism 50 (see FIG8 ). After being released, the movable body 20 can be moved toward the proximal end 101 together with the puncture member 40 under the action of the drive mechanism 50 to apply the monitoring device 800 to the host and position it at least partially subcutaneously. In this case, the drive mechanism 50 can provide a relatively precise driving action, thereby more accurately controlling the puncture force and puncture depth of the puncture member 40 during the application process, thereby facilitating accurate application of the monitoring device 800 to the host.

[0095] In some examples, the drive mechanism 50 may include a first drive portion 51 (see FIG. 9 ). The first drive portion 51 may be configured to drive the moving body 20. In some examples, the first drive portion 51 may apply force to the moving body 20 toward the proximal end 101. When the moving body 20 is released, the moving body 20 may be driven toward the proximal end 101 by the first drive portion 51 to push the monitoring device 800 contained in the receiving portion 21 toward the host.

[0096] In other examples, the applying device 100 may not include the first driving portion 51. In this case, when the moving body 20 is released, the moving body 20 may also be manually driven to move toward the proximal end 101.

[0097] In some examples, the drive mechanism 50 may include a second drive unit 52 (see FIG. 9 ). The second drive unit 52 may be configured to drive the piercing member 40. In some examples, the second drive unit 52 may apply force to the piercing member 40 toward the distal end 102. When the piercing member 40 is released, the second drive unit 52 may cause the piercing member 40 to move toward the distal end 102, thereby removing the piercing member 40 from the host. In this case, retracting the piercing member 40 using the second drive unit 52 can more accurately control the timing of the piercing member 40's removal from the host.

[0098] In other examples, the application device 100 may not include the second drive unit 52. In this case, the piercing member 40 can be manually driven away from the host. For example, in some examples, the piercing member 40 can be integrally connected to the moving body 20, and the piercing member 40 can be moved away from the host by manually moving the moving body 20 in a direction away from the host.

[0099] In some examples, the application device 100 may include a transmission mechanism 7 (see FIG8 ). In some examples, the transmission mechanism 7 may abut the end of the movable body 20 that faces the distal end 102, and the ends of the first driving portion 51 may abut the transmission mechanism 7 and the first housing 10, respectively. In this case, the first driving portion 51 can apply force to the movable body 20 toward the proximal end 101 via the transmission mechanism 7. In some examples, the transmission mechanism 7 can accommodate the piercing member 40 that has been released to move toward the distal end 102. In this case, the transmission mechanism 7 can help stably maintain the piercing member 40 within the first housing 10 after it has moved toward the distal end 102.

[0100] Figure 10 is a schematic diagram illustrating the first housing 10 according to an example of the present disclosure. Figure 11 is a schematic diagram illustrating the second housing 30 according to an example of the present disclosure. Figure 12 is a schematic diagram illustrating the moving body 20 according to an example of the present disclosure. Figure 13 is a schematic cross-sectional diagram illustrating the assembled first housing 10, second housing 30, and moving body 20 according to an example of the present disclosure.

[0101] In some examples, one or more rib-like protrusions 11 (see FIG. 10 ) extending generally along the central axis CA may be provided on the inner wall of the first housing 10. In some examples, the rib-like protrusions 11 may serve as reinforcement ribs to effectively improve the deformation resistance of the first housing 10. In some examples, the rib-like protrusions 11 may also serve as guide ribs to facilitate assembly of the first housing 10 and the second housing 30. The guide ribs further help prevent the second housing 30 from rotating unintentionally within the first housing 10.

[0102] In some examples, a male-female mechanical mating structure may be provided on the inner wall of the first housing 10 and the outer wall of the second housing 30. In some examples, the male-female mechanical mating structure may be a concave-convex mating structure. For example, in some examples, one or more rib-like protrusions 11 may be provided on the inner wall of the first housing 10, and one or more rib-like grooves 32 may be provided on the outer wall of the second housing 30 (see Figures 10 and 11). In some examples, when the second housing 30 is assembled with the first housing 10, the one or more rib-like protrusions 11 of the first housing 10 may fit into the one or more rib-like grooves 32 of the second housing 30. In this case, the mating of the rib-like protrusions 11 and the rib-like grooves 32 facilitates assembly of the first and second housings 10, 30. Furthermore, the mating of the rib-like protrusions 11 and the rib-like grooves 32 can guide the direction of relative movement between the first and second housings 10, 30. Furthermore, the mating of the rib-like protrusions 11 and the rib-like grooves 32 can help prevent undesirable rotation of the second housing 30. In some examples, the plurality of rib-shaped protrusions 11 provided on the inner wall of the first shell 10 may be evenly or symmetrically distributed on the inner wall of the first shell 10 .

[0103] In some examples, a recessed structure can be formed in the rib-shaped protrusion 11 on the inner wall of the first housing 10, and a raised structure can be formed in the rib-shaped groove 32 on the outer wall of the second housing 30. When the second housing 30 is assembled with the first housing 10, the rib-shaped protrusion 11 of the first housing 10 can be located in the rib-shaped groove 32 of the second housing 30, and the raised structure in the rib-shaped groove 32 can be located in the recessed structure in the rib-shaped protrusion 11. This can further improve the assembly stability of the first housing 10 and the second housing 30 and further define the guide path, facilitating more precise directional guidance during relative movement of the first housing 10 and the second housing 30.

[0104] In some examples, as described above, the moving body 20 can be releasably retained by the first housing 10. In some examples, the first housing 10 can include a first retaining portion 12 (see FIG. 10 ). The first retaining portion 12 can be configured to releasably retain the moving body 20. In some examples, the first retaining portion 12 can be disposed on an inner wall of the first housing 10. For example, in some examples, the first retaining portion 12 can be a convex structure formed on the inner wall of the first housing 10.

[0105] In some examples, the moving body 20 may include a first locking portion 23 (see FIG. 12 ). The first locking portion 23 may be configured to releasably interlock with the first retaining portion 12 . Thus, the moving body 20 can be releasably retained in the first retaining portion 12 through the engagement of the first locking portion 23 with the first retaining portion 12 . In some examples, the moving body 20 may include a sidewall 22 . In some examples, the first locking portion 23 may be disposed on the sidewall 22 of the moving body 20 .

[0106] In some examples, the interlocking between the first retaining portion 12 and the retained member can be achieved by at least one of a snap, hook, latch, or pin. For example, in some examples, the interlocking between the first retaining portion 12 and the first locking portion 23 can be achieved by at least one of a snap, hook, latch, or pin. In this case, the first retaining portion 12 and the first locking portion 23 are releasably interlocked by at least one of a snap, hook, latch, or pin, thereby providing an interlocking method that is easy to release.

[0107] In some examples, as described above, the first retaining portion 12 can be a convex structure formed on the inner wall of the first housing 10 (see FIG. 10 ). In some examples, when the moving body 20 is retained by the first retaining portion 12, the first locking portion 23 engages with the convex structure. The first locking portion 23 can be disengaged from the first retaining portion 12 by deflecting the first locking portion 23 away from the first retaining portion 12. Since under normal circumstances, in order to make the target component shift, it is generally carried out by adjusting the material or adjusting the structure, for example, using a soft material to prepare the target component or setting a target component with a certain length, such a target component can be shifted under the action of external force. In the present disclosure, in order to enable the first shell 10 to protect the internal structure, a harder material is usually used to prepare the first shell 10. In this case, compared with setting a first retaining portion 12 with a certain length that can be shifted inside the first shell 10, setting the first retaining portion 12 as a convex structure formed on the inner wall of the first shell 10 can reduce the space required for setting the first retaining portion 12 while reducing the difficulty of the preparation process of the first shell 10, thereby contributing to the miniaturization of the application device 100 and facilitating use by the operator.

[0108] In some examples, the first retaining portion 12 may have a surface facing the distal end 102, and the first locking portion 23 may have a surface facing the proximal end 101. When the moving body 20 is retained, the surface of the first retaining portion 12 facing the distal end 102 and the surface of the first locking portion 23 facing the proximal end 101 may engage with each other. In some examples, when the moving body 20 is released, the surface of the first retaining portion 12 facing the distal end 102 and the surface of the first locking portion 23 facing the proximal end 101 may separate from each other.

[0109] In some examples, the first locking portion 23 may include an arm 230 extending generally along the direction of the central axis CA (hereinafter referred to as the first arm 230 for ease of reading), and a protrusion 231 (hereinafter referred to as the first protrusion 231 for ease of reading) that is linked to the first arm 230 and protrudes away from the central axis CA in a direction generally perpendicular to the central axis CA (see FIG12 ). In some examples, the first arm 230 may be formed on the sidewall 22 of the moving body 20. In this case, when the first protrusion 231 of the first locking portion 23 is engaged with the first retaining portion 12, the first protrusion 231 is actuated to move toward the central axis CA so that the first protrusion 231 no longer engages the first retaining portion 12 (i.e., the first locking portion 23 is separated from the first retaining portion 12), thereby conveniently releasing the first locking portion 23 from the first retaining portion 12.

[0110] In some examples, the first arm 230 can be elastic. In some examples, the first arm 230 can be elastic in a direction generally perpendicular to the central axis CA. In some examples, the first arm 230 can tend to expand away from the central axis CA in the direction from the proximal end 101 to the distal end 102. That is, in a natural state (i.e., when not subjected to external force), the end of the first arm 230 closer to the proximal end 101 is closer to the central axis CA than the end of the first arm 230 closer to the distal end 102. In other examples, the first arm 230 can also be generally parallel to the central axis CA. In some examples, when a force is applied to the first arm 230 in a direction generally perpendicular to the central axis CA, the first arm 230 can pivot. For example, when an action is applied to the first arm 230 in a direction substantially perpendicular to the central axis CA and directed toward the central axis CA, the first arm 230 may deflect, so that the end of the first arm 230 closer to the distal end 102 moves toward the central axis CA. Thus, the moving body 20 can be released easily.

[0111] In some examples, the first arm 230 can expand in a direction away from the central axis CA along the direction from the proximal end 101 to the distal end 102, and the first protrusion 231 of the first locking portion 23 can protrude in a direction away from the central axis CA. In this case, the first locking portion 23 can be interlocked with the first retaining portion 12 on the outside (away from the central axis CA) by expanding the first locking portion 23 as a whole, and can be released by actuating the first locking portion 23 toward the inside (closer to the central axis CA) to disengage the first locking portion 23 from the first retaining portion 12.

[0112] In some examples, the first protrusion 231 may have a surface facing the proximal end 101. In some examples, the surface of the first protrusion 231 facing the proximal end 101 may be substantially perpendicular to the central axis CA. The first locking portion 23 may be retained by overlapping / abutting against the surface of the first retaining portion 12 facing the distal end 102. This helps to inhibit movement of the moving body 20 toward the proximal end 101. When the first locking portion 23 is actuated, causing the surface of the first protrusion 231 facing the proximal end 101 to move away from its original position, that is, no longer overlapping the surface of the first retaining portion 12 facing the distal end 102, the first locking portion 23 is released. In other words, the first locking portion 23 may be a structure such as a buckle, hook, latch, or pin formed on the moving body 20. For example, the first locking portion 23 can be formed into a finger-shaped, straight-shaped, L-shaped, J-shaped or Z-shaped structure that can be decomposed into at least two parts, at least one part of which (for example, the first arm 230 connected to the side wall 22 of the moving body 20) can pivot, and the other part (for example, a convex structure protruding outward from the first arm 230 and abutting against the first retaining portion 12) can leave the initial position as it pivots, thereby releasing the hook, hang, latch, push, support, etc. of the retained object.

[0113] In some examples, the number of first retaining portions 12 may be one or more. For example, the number of first retaining portions 12 may be one, two, three, or four. Correspondingly, the number of first locking portions 23 may be the same as the number of first retaining portions 12. In the embodiment shown in FIG12 , the number of first locking portions 23 is two, and the two first locking portions 23 may be symmetrically distributed on opposite sides of the moving body 20. This helps to stably retain the moving body 20 and improve the reliability of the application device 100.

[0114] In some examples, as described above, the first housing 10 and the second housing 30 can move relative to each other to release the moving body 20. In some examples, the second housing 30 can include a first trigger portion 33. The first trigger portion 33 can be configured to separate the first retaining portion 12 from the first locking portion 23 to release the moving body 20. Thus, the first trigger portion 33 can facilitate the release of the moving body 20 through relative movement of the two housings.

[0115] In some examples, the second housing 30 and the first housing 10 can move relative to each other in a manner that approaches each other to release the first retaining portion 12 from retaining the moving body 20. In some examples, the first housing 10 and the second housing 30 can move relative to each other along the direction of the central axis CA to release the first retaining portion 12 from retaining the moving body 20. In this case, by moving the two housings relative to each other in the direction of the central axis CA, the first locking portion 23 can be separated from the first retaining portion 12 by the first trigger portion 33, which can facilitate use by the operator. In the example shown in Figure 13, the relative movement of the first housing 10 and the second housing 30 in a manner that approaches each other can include the first housing 10 moving in the direction F1 (i.e., moving in the direction close to the proximal end 101), the second housing 30 moving in the direction F2 (i.e., moving in the direction close to the distal end 102), or the first housing 10 moving in the direction F1 while the second housing 30 moves in the direction F2.

[0116] In some examples, the first trigger portion 33 can be formed on a side wall of the second housing 30. In some examples, the first trigger portion 33 can include a trigger arm 330 (see FIG. 11 ) that extends generally along the direction of the central axis CA. When the first housing 10 and the second housing 30 move relative to each other, the trigger arm 330 can act on the first locking portion 23 to separate the first locking portion 23 from the first retaining portion 12.

[0117] In some examples, the first locking portion 23 may include a protrusion 232 (hereinafter referred to as the second protrusion 232 for ease of reading) that protrudes away from the central axis CA in a direction substantially perpendicular to the central axis CA (see FIG. 12 ). The second protrusion 232 may be provided on the first arm 230. In some examples, the first triggering portion 33 may act on the second protrusion 232 to cause the first arm 230 to deflect.

[0118] In some examples, the second protrusion 232 may have a surface facing the proximal end 101. In some examples, the trigger arm 330 may have a surface facing the distal end 102. When the first housing 10 and the second housing 30 move relative to each other, the first trigger portion 33 first moves to abut against the second protrusion 232, causing the surface of the trigger arm 330 facing the distal end 102 to contact the surface of the second protrusion 232 facing the proximal end 101. As the movement continues, the second protrusion 232 is compressed, causing the first arm 230 to gradually deflect toward the central axis CA. When the first arm 230 deflects away from the first retaining portion 12, the movable body 20 is released. This facilitates unlocking the movable body 20 by relative movement between the first housing 10 and the second housing 30, thereby facilitating use by the operator.

[0119] In some examples, the surface of the second protrusion 232 facing the proximal end 101 and / or the surface of the trigger arm 330 facing the distal end 102 can be an inclined surface or a curved surface. In this case, it is possible to facilitate the movement of the second protrusion 232 under the action of the trigger arm 330 when the second protrusion 232 abuts against the trigger arm 330.

[0120] In some examples, when the moving body 20 is retained by the first retaining portion 12, the second protrusion 232 is closer to the first triggering portion 33 than the first protrusion 231. That is, when the moving body 20 is retained by the first retaining portion 12, along the direction from the proximal end 101 to the distal end 102, the second protrusion 232 is closer to the proximal end 101 than the first protrusion 231. In this case, the moving body 20 can be easily unlocked by relatively moving the first housing 10 and the second housing 30 closer to each other.

[0121] In some examples, the first protrusion 231 and the second protrusion 232 may be staggered in the vertical direction and / or the horizontal direction. The vertical staggering of the first protrusion 231 and the second protrusion 232 may mean that the vertical axes of the first protrusion 231 and the second protrusion 232 do not overlap, or that the first protrusion 231 and the second protrusion 232 do not overlap when projected along the vertical direction. The horizontal staggering has the same meaning as the vertical staggering. In this case, since the first protrusion 231, the second protrusion 232, the first retaining portion 12 of the first shell 10, and the trigger arm 330 of the second shell 30 are related to each other, it is necessary to consider the positional relationship between the various components during design, as well as the utilization rate of the internal space of the first shell 10. In this embodiment, the first protrusion 231 and the second protrusion 232 are configured to be staggered in the vertical direction and / or horizontal direction. Compared with the solution of arranging the two protrusions on the same axis, it can save space, improve the integration of the internal structure of the application device 100, and contribute to the miniaturization of the application device 100.

[0122] In some examples, the first protrusion 231 and the second protrusion 232 can be offset in both the vertical and horizontal directions. When the moving body 20 is retained by the first retaining portion 12, the first retaining portion 12 can be horizontally adjacent to the second protrusion 232 and in contact with the first protrusion 231. In this case, the first retaining portion 12 can vertically overlap with the first protrusion 231. In this case, when the first protrusion 231 is actuated and disengaged from the first retaining portion 12, the second protrusion 232 and the trigger arm 330 are not in the path of the first protrusion 231 moving toward the proximal end 101, which facilitates smooth actuation of the moving body 20 to the host.

[0123] In some examples, the number of second protrusions 232 in a first locking portion 23 can be one or more. For example, the number of second protrusions 232 can be one, two, three, or four. In the embodiment shown in Figure 12, the number of second protrusions 232 is four (one of the second protrusions 232 is not shown due to viewing angle issues), and the four second protrusions 232 are arranged in pairs on the first locking portion 23. Correspondingly, the number of first triggering portions 33 can be consistent with the number of second protrusions 232. In the embodiment shown in Figure 11, the number of first triggering portions 33 is four, and the four first triggering portions 33 correspond to the positions of the four second protrusions 232. In this case, it can help to separate the first locking portion 23 and the first retaining portion 12 by applying an action on the second protrusions 232 by the first triggering portion 33 when the two housings move relative to each other.

[0124] FIG14 is a cross-sectional schematic diagram showing the first locking portion 23 involved in the example of the present disclosure before being triggered by the first triggering portion 33. FIG15 is a cross-sectional schematic diagram showing the first locking portion 23 involved in the example of the present disclosure after being triggered by the first triggering portion 33. It should be noted that FIG14 and FIG15 are enlarged views of the area A in FIG13, and FIG14 and FIG15 mainly illustrate the triggering of the first locking portion 23 by the first triggering portion 33. For a clearer illustration, some lines that may cause obstruction are omitted, and the gaps between the components are enlarged. In addition, in FIG15, for a clearer illustration, only the first retaining portion 12, the first locking portion 23 and the first triggering portion 33 are marked. The specific structural details of these components can be found in FIG14.

[0125] 14 and 15 , the triggering of the first locking portion 23 by the first triggering portion 33 will be described in detail. As previously described, before the first triggering portion 33 actuates the first locking portion 23, the first locking portion 23 contacts the first retaining portion 12, which restricts movement of the first locking portion 23 toward the proximal end 101, thereby retaining the movable body 20 (see FIG14 ). When the first triggering portion 33 actuates the first locking portion 23 (e.g., when the two housings move toward each other), the first arm 230 and the first protrusion 231 gradually converge inward (i.e., move toward the central axis CA) under the action of the first triggering portion 33. When the first protrusion 231 separates from the first retaining portion 12, the movable body 20 is released (see FIG15 ).

[0126] In some examples, after being released, the moving body 20 can move toward the proximal end 101. In some examples, when the moving body 20 applies the monitoring device 800 to the host, the end of the moving body 20 near the proximal end 101 can be flush with the proximal end 101 of the application device 100. This facilitates application of the monitoring device 800 located in the receiving portion 21 to the host.

[0127] In some examples, the first retaining portion 12 has a surface facing the proximal end 101. In some examples, the first triggering portion 33 has a first surface 331 and a second surface 332 facing the distal end 102 (see FIG14 ). The first surface 331 may face the first locking portion 23, and the second surface 332 may face the first retaining portion 12. When the first shell 10 and the second shell 30 move relative to each other in a manner approaching each other, the first surface 331 may first contact the first locking portion 23 and act on the first locking portion 23 during the movement, and as the movement continues, the second surface 332 may contact the surface of the first retaining portion 12 facing the proximal end 101. Thus, it is possible to facilitate applying an action toward the center axis CA to the first locking portion 23 to separate the first locking portion 23 from the first retaining portion 12.

[0128] In some examples, when the first housing 10 and the second housing 30 move relative to each other along the central axis CA, the first trigger portion 33 can act on the first locking portion 23 to separate the first locking portion 23 from the first retaining portion 12. In this case, the first locking portion 23 can be separated from the first retaining portion 12 by the first trigger portion 33 simply by moving the two housings relative to each other along the central axis CA, which can facilitate operation.

[0129] In some examples, the proximal surface 31 of the second housing 30 can be placed on the host's skin, and an action toward the host can be applied to the first housing 10 (for example, the operator presses the first housing 10 toward the host), causing the first housing 10 and the second housing 30 to move toward each other, thereby releasing the moving body 20. After being released, the moving body 20 moves toward the proximal end 101 together with the puncture member 40 to apply the monitoring device 800 to the host's body surface, and at least a portion of the monitoring device 800 is introduced into the host's subcutaneous tissue through the puncture member 40. This facilitates the host to operate the application device 100 with one hand.

[0130] In some examples, the second shell 30 may include one or more protruding structures 391 (see FIG11 ). In some examples, the protruding structure 391 may protrude from the inner wall of the second shell 30 in a direction substantially perpendicular to the central axis CA in a direction away from the central axis CA. In some examples, the protruding structure 391 may be loosely fitted with the inner wall of the first shell 10. In this case, the protruding structure 391 can help suppress unwanted shaking and / or rotation of the second shell 30 within the first shell 10, thereby improving the reliability of the application device 100. In some examples, multiple protruding structures 391 may be dispersed around the periphery of the second shell 30.

[0131] In some examples, the first housing 10 may include a first restricting portion 13 (see FIG. 10 ). The first restricting portion 13 may restrict the second housing 30, thereby preventing the second housing 30 from detaching from the first housing 10. This may help improve the reliability of the application device 100. That is, in some examples, the first housing 10 may include a first restricting portion 13 configured to prevent the second housing 30 from detaching from the first housing 10.

[0132] In some examples, the first limiting portion 13 may be a convex structure formed on the inner wall of the first housing 10 (see FIG. 10 ).

[0133] In some examples, the second housing 30 may include a first restricted portion 34 (see FIG. 11 ). The first restricted portion 34 may be coupled to the first restricted portion 13. In some examples, the first restricted portion 34 may be disposed on a sidewall of the second housing 30. In some examples, the interlocking between the first restricted portion 13 and the first restricted portion 34 may be achieved by at least one of a snap, a hook, a latch, or a pin.

[0134] In some examples, when the moving body 20 is held by the first holding portion 12, the first restricting portion 34 may be coupled to the first restricting portion 13. Thus, in the standby state where the moving body 20 is held by the first holding portion 12, the second housing 30 can be restricted, thereby preventing the second housing 30 from detaching from the first housing 10.

[0135] In some examples, the first restricting portion 13 may have a surface facing the distal end 102. In some examples, the first restricting portion 34 may have a surface facing the proximal end 101. When the moving body 20 is held by the first holding portion 12, the surface of the first restricting portion 13 facing the distal end 102 may engage with the surface of the first restricting portion 34 facing the proximal end 101. In some examples, when the moving body 20 is held by the first holding portion 12, the first restricting portion 34 is closer to the distal end 102 than the first restricting portion 13.

[0136] In some examples, the first limiting portion 34 may include an extension portion 340 extending substantially along the direction of the central axis CA, and a snap-fit ​​portion 341 (see FIG. 11 ) coupled to the extension portion 340. When the snap-fit ​​portion 341 is engaged with the first limiting portion 13, the second housing 30 may be constrained by the first housing 10.

[0137] In some examples, the first shell 10 may include a second limiting portion 14 (see Figure 10). The second limiting portion 14 can impose restrictions on the second shell 30. Specifically, the second limiting portion 14 can be configured to inhibit the movement of the second shell 30 toward the proximal end 101. After the first shell 10 and the second shell 30 move relative to each other to release the moving body 20, the second shell 30 can be restricted by the second limiting portion 14. In this case, the second limiting portion 14 can limit the movement of the second shell 30 toward the proximal end 101, thereby inhibiting the operator from reusing the application device 100, and reducing the risk of the used puncture member 40 that has not been sterilized for the second time coming into contact with the host again. In some examples, the second limiting portion 14 can be a convex structure formed on the inner wall of the first shell 10.

[0138] In some examples, the second housing 30 may include a second restricting portion 35 (see FIG. 11 ). The second restricting portion 35 may be configured to interlock with the second restricting portion 14 . Thus, the second housing 30 can be retained on the first retaining portion 12 through the engagement of the second restricting portion 35 with the second restricting portion 14 . Specifically, after the first housing 10 and the second housing 30 move relative to each other, releasing the first retaining portion 12 from retaining the moving body 20, the second restricting portion 35 can engage with the second restricting portion 14 .

[0139] In some examples, when the moving body 20 is retained by the first retaining portion 12, the second restricted portion 35 is closer to the proximal end 101 than the second restricted portion 14; when the moving body 20 is in the released state, the second restricted portion 35 is closer to the distal end 102 than the second restricted portion 14. In some examples, the interlocking between the second restricted portion 14 and the second restricted portion 35 can be achieved by at least one of a buckle, a hook, a latch, or a pin.

[0140] In some examples, the second restricting portion 14 may have a surface facing the distal end 102. In some examples, the second restricting portion 35 may have a surface facing the proximal end 101. When the second housing 30 is retained, the surface of the second restricting portion 14 facing the distal end 102 and the surface of the second restricting portion 35 facing the proximal end 101 may engage with each other.

[0141] In some examples, the structure of the second restricted portion 35 can be consistent with the structure of the first restricted portion 34. That is, the second restricted portion 35 can also include an extension portion 340 and a clamping portion 341. In some examples, the first restricted portion 34 and the second restricted portion 35 can be the same structure. That is, in addition to cooperating with the first restricting portion 13, the first restricted portion 34 can also cooperate with the second restricting portion 14 to retain the second shell 30. In other words, in some examples, the first restricted portion 34 can be configured to cooperate with the second restricting portion 14 to retain the second shell 30. This can help simplify the structure of the application device 100.

[0142] In some examples, the first restricted portion 34 can form an H-shaped structure or an arch-shaped structure (see Figure 11). In this case, the second shell 30 can be restricted by the first restricting portion 13 or the second restricting portion 14 by overlapping the crossbar structure in the first restricted portion 34 with the first restricting portion 13 or the second restricting portion 14. In some examples, the extension portion 340 and the clamping portion 341 can cooperate to form an H-shaped structure or an arch-shaped structure. Among them, the extension portion 340 can constitute the vertical structure in the H-shaped structure or the arch-shaped structure, and the clamping portion 341 can constitute the crossbar structure in the H-shaped structure. In this case, on the one hand, the cooperation of the vertical structure helps to suppress the undesirable rotation of the second shell within the first shell; on the other hand, the structure formed by the extension portion 340 and the clamping portion 341 is a single-layer structure compared to the L-shaped structure in the same thickness direction. The L-shaped structure is a double-layer structure. Therefore, the single-layer structure helps to reduce the required space in the same width direction of the application device 100 compared to the double-layer structure, thereby facilitating the cooperation with other components to form a compact structure and improve the utilization rate of the internal space of the first shell. In other examples, the extension portion 340 and the clamping portion 341 can also cooperate to form an L-shaped, J-shaped, or Z-shaped structure.

[0143] In other examples, the extension portion 340 may be an arm extending in the direction of the central axis CA (hereinafter referred to as the second arm for ease of reading) (see FIG11 ). In some examples, the clamping portion 341 may be provided on the extension portion 340 (see FIG11 ). In this case, the extension portion 340 and the clamping portion 341 may cooperate to form a structure that can couple with the first restricting portion 13 and the second restricting portion 14. In some examples, the clamping portion 341 and the extension portion 340 may be integrally formed.

[0144] In some examples, the second arm may be elastic. In some examples, the second arm may be elastic in a direction generally perpendicular to the central axis CA. In some examples, the second arm may tend to expand away from the central axis CA in the direction from the proximal end 101 to the distal end 102. That is, in a natural state (i.e., when not subjected to external forces), the end of the second arm closer to the proximal end 101 is closer to the central axis CA than the end of the second arm closer to the distal end 102. In other examples, the second arm may be generally parallel to the central axis CA.

[0145] In some examples, when an action is applied to the second arm in a direction generally perpendicular to the central axis CA, the second arm can pivot. For example, when an action is applied to the second arm in a direction generally perpendicular to the central axis CA and toward the central axis CA, the second arm can deflect, causing the end of the second arm proximal to the distal end 102 to move toward the central axis CA. In this case, when the first housing 10 and the second housing 30 move toward each other, the second arm can be deflected, causing the engaging portion 341 to span across the second restricting portion 14 and engage the second restricting portion 14.

[0146] In some examples, the second arm can be formed on the side wall of the second housing 30. In some examples, the second arm can also serve as a portion of the side wall of the second housing 30. When the engaging portion 341 of the second restricting portion 35 overlaps the second restricting portion 14, the second housing 30 can be retained.

[0147] In some examples, the second arm can expand in a direction away from the central axis CA along the direction from the proximal end 101 to the distal end 102, and the engaging portion 341 can protrude in a direction away from the central axis CA. In this case, the second restricted portion 35 can be interlocked with the second restricted portion 14 on the outer side (away from the central axis CA) by expanding the second restricted portion 35 as a whole outward.

[0148] In some examples, the second limiting portion 14 may have a surface facing the proximal end 101. In some examples, the engaging portion 341 may have a surface facing the distal end 102. When the first housing 10 and the second housing 30 move relative to each other in a manner approaching each other, the surface of the engaging portion 341 facing the distal end 102 first contacts the surface of the second limiting portion 14 facing the proximal end 101. During continued movement, the engaging portion 341 is squeezed by the second limiting portion 14 and deflected as a whole toward the direction approaching the central axis CA. When the surface of the engaging portion 341 facing the proximal end 101 is closer to the distal end 102 than the surface of the second limiting portion 14 facing the distal end 102, the engaging portion 341 is released from the squeezing of the second limiting portion 14 and expands outward, thereby engaging the surface of the second limiting portion 14 facing the distal end 102 with the surface of the engaging portion 341 facing the proximal end 101 to retain the second housing 30.

[0149] In some examples, the surface of the second limiting portion 14 facing the proximal end 101 and / or the surface of the engaging portion 341 facing the distal end 102 may be an inclined or curved surface. In this case, when the two housings move relative to each other, the engaging portion 341, under pressure from the second limiting portion 14, can smoothly cross over the surface of the second limiting portion 14 facing the proximal end 101 and overlap the second limiting portion 14.

[0150] In some examples, after the moving body 20 is released, the first limiting portion 34 may be separated from the first limiting portion 13. In some examples, after the moving body 20 is released, the second housing 30 may be retained on the second limiting portion 14 via the second limiting portion 35.

[0151] In some examples, the structure of the first restricting portion 13 can be consistent with that of the second restricting portion 14. In some examples, the first restricting portion 13 can be arranged adjacent to the second restricting portion 14 along the direction of the central axis CA. In some examples, the first restricting portion 13 is closer to the proximal end 101 than the second restricting portion 14. In this case, before the moving body 20 is released, the second housing 30 can be restricted by the first housing 10 through the cooperation between the first restricting portion 34 and the first restricting portion 13. After the first housing 10 and the second housing 30 move relative to each other so as to approach each other, causing the moving body 20 to be released, the second housing 30 can be restricted by the first housing 10 through the cooperation between the first restricting portion 34 and the second restricting portion 14.

[0152] In some examples, the number of first restricting portions 13 may be one or more. For example, the number of first restricting portions 13 may be one, two, three, or four. The number of first restricting portions 34 may be the same as the number of first restricting portions 13. In some examples, the number of second restricting portions 14 may be one or more. For example, the number of second restricting portions 14 may be one, two, three, or four.

[0153] Figure 16 is a schematic cross-sectional view illustrating the first restricting portion 34 of the present disclosure, not engaged with the second restricting portion 14. Figure 17 is a schematic cross-sectional view illustrating the first restricting portion 34 of the present disclosure, engaged with the second restricting portion 14. It should be noted that Figures 16 and 17 primarily illustrate the coordination between the first restricting portion 34, the first restricting portion 13, and the second restricting portion 14, omitting certain lines that could obscure or mislead.

[0154] 16 and 17 , the cooperation among the first restricting portion 34 , the first restricting portion 13 and the second restricting portion 14 will be described in detail. As mentioned above, before the first trigger portion 33 actuates the first locking portion 23 (i.e., when the moving body 20 is maintained in the standby state of the first retaining portion 12), the first limiting portion 34 can engage with the first limiting portion 13, and the first limiting portion 13 can limit the movement of the second shell 30 toward the proximal end 101 (see Figure 16); when the two shells move relative to each other in the direction of the central axis CA, the first limiting portion 34 is squeezed inward by the second limiting portion 14, and the second arm and the clamping portion 341 gradually retract inward (i.e., move in the direction close to the central axis CA). When the surface of the clamping portion 341 facing the proximal end 101 is higher than the surface of the second limiting portion 14 facing the distal end 102, the clamping portion 341 disengages from the squeezing of the second limiting portion 14 and expands outward, so that the surface of the second limiting portion 14 facing the distal end 102 and the surface of the clamping portion 341 facing the proximal end 101 engage with each other to hold the second shell 30 (see Figure 17).

[0155] In some examples, the second limiting portion 14 may not be provided. In this case, when the action of causing the first shell 10 and the second shell 30 to move relative to each other is stopped, the second shell 30 and the first shell 10 can automatically return to the standby position to prepare for the next use. In the example of a reusable application device 100, the needle portion 41 and the support seat 43 in the puncture member 40 can be configured to be detachably engaged. After completing an application action, the needle portion 41 can be removed from the support seat 43, replaced with a new sterilized needle portion 41, and a new monitoring device 800 can be assembled to the application device 100 to prepare for the next use.

[0156] In some examples, a male-female mechanical mating structure may be provided on the side wall of the second shell 30 and the side wall 22 of the moving body 20. In some examples, the second shell 30 may include a third engaging feature 38, and the moving body 20 may include a fourth engaging feature 28 (see Figures 11 and 12). A male-female mechanical mating structure may be formed by the third engaging feature 38 cooperating with the fourth engaging feature 28. In some examples, the male-female mechanical mating structure may be a concave-convex mating structure. In some examples, the third engaging feature 38 may be one or more rib-like protrusions provided on the side wall of the second shell 30, and the fourth engaging feature 28 may be one or more rib-like grooves provided on the side wall 22 of the moving body 20 (see Figures 11 and 12). In some examples, when the moving body 20 is assembled to the second shell 30, the one or more rib-like protrusions of the second shell 30 may be respectively embedded in the one or more rib-like grooves of the moving body 20. In this case, on the one hand, the matching of the rib-shaped protrusions and the rib-shaped grooves can facilitate the assembly of the second shell 30 and the moving body 20; on the other hand, the rib-shaped protrusions and the rib-shaped grooves can also guide the moving direction of the moving body 20; in addition, the matching of the rib-shaped protrusions and the rib-shaped grooves can also help to suppress the moving body 20 from unexpected rotation.

[0157] In some examples, the plurality of rib-shaped protrusions provided on the sidewall of the second housing 30 may be evenly or symmetrically distributed on the sidewall of the second housing 30 .

[0158] In some examples, the second housing 30 may include a third limiting portion 36 (see FIG. 11 ). The third limiting portion 36 can restrict the moving body 20. In some examples, the third limiting portion 36 can be at least partially located along the trajectory of the moving body 20 as it moves toward the proximal end 101. In this case, when the moving body 20 moves toward the proximal end 101 and reaches the third limiting portion 36, the third limiting portion 36 can restrict the moving body 20, causing it to stop moving. This allows the monitoring device 800 to be applied to a predetermined position while also preventing the moving body 20 from detaching from the second housing 30. This improves the reliability of the application device 100.

[0159] In some examples, the moving body 20 may include a third restricted portion 24 (see FIG. 12 ). The third restricted portion 24 may be coupled to a third restricting portion 36 to restrict the moving body 20 to the second housing 30. In some examples, the interlocking between the third restricting portion 36 and the third restricting portion 24 may be achieved by at least one of a snap, a hook, a latch, or a pin. In some examples, the third restricting portion 36 may be disposed on a sidewall of the second housing 30. In some examples, the third restricting portion 24 may be disposed on a sidewall 22 of the moving body 20.

[0160] In some examples, when the moving body 20 is held by the first holding portion 12, the third restricted portion 24 is closer to the distal end 102 than the third restricted portion 36. In some examples, the third restricted portion 36 may have a surface facing the distal end 102. In some examples, the third restricted portion 24 may have a surface facing the proximal end 101. When the moving body 20 moves toward the proximal end 101 until the third restricted portion 24 contacts the third restricted portion 36, the surface of the third restricted portion 36 facing the distal end 102 may engage with the surface of the third restricted portion 24 facing the proximal end 101.

[0161] In some examples, the third restricted portion 24 may include an arm 240 extending generally along the direction of the central axis CA (hereinafter referred to as the third arm 240 for ease of reading), and a protrusion 241 that is linked to the third arm 240 and protrudes away from the central axis CA in a direction generally perpendicular to the central axis CA (hereinafter referred to as the third protrusion 241 for ease of reading). In this case, when the third protrusion 241 of the third restricted portion 24 overlaps the third restricting portion 36, the movable body 20 can be restricted.

[0162] In some examples, the third arm 240 can be elastic. In some examples, the third arm 240 can be elastic in a direction generally perpendicular to the central axis CA. In some examples, when an action is applied to the third arm 240 in a direction generally perpendicular to the central axis CA, the third arm 240 can pivot. In this case, assembly of the moving body 20 to the second housing 30 can be facilitated. In some examples, the third arm 240 can tend to expand away from the central axis CA in a direction from the proximal end 101 to the distal end 102. In this case, after the moving body 20 is assembled with the second housing 30, the third protrusion 241 can be positioned above the third limiting portion 36, thereby enabling the third protrusion 241 to overlap the third limiting portion 36 when the moving body 20 is subsequently moved toward the proximal end 101.

[0163] In some examples, the axis of the second shell 30 and the axis of the moving body 20 can be roughly parallel to the central axis CA. In some examples, the second shell 30 and the moving body 20 can be coaxially arranged. For example, in Figure 8, the axis of the second shell 30 and the axis of the moving body 20 can overlap with the central axis CA. In some examples, the second shell 30 and the moving body 20 can be arranged to overlap. Specifically, a hollow portion 39 (see Figure 11) can be provided on the second shell 30, and some components of the moving body 20 (such as the first locking portion 23) can be inserted into the hollow portion 39. In this case, the internal space utilization of the first shell 10 can be improved, which helps to miniaturize the application device 100. In some examples, the moving body 20 can be movably embedded in the second shell 30.

[0164] In some examples, the number of the third restricting portions 36 may be one or more. For example, the number of the third restricting portions 36 may be 1, 2, 3, or 4. The number of the third restricting portions 24 and the third restricting portions 36 may be the same.

[0165] In some examples, the moving body 20 may include sidewalls and a first bottom portion 25 facing the proximal end 101 (see FIG. 12 ). In some examples, the first driving portion 51 may be located between the first housing 10 and the moving body 20. This facilitates the first driving portion 51 from applying force to the moving body 20. For example, in some examples, the first driving portion 51 may be located between the first housing 10 and the first bottom portion 25 of the moving body 20. In another example, in some examples, the first driving portion 51 may be located between the first housing 10 and the top portion of the moving body 20.

[0166] In some examples, a first positioning portion 251 for positioning the first driving portion 51 may be provided on the first bottom portion 25. In this case, the first positioning portion 251 can more stably define the position where the first driving portion 51 acts on the moving body 20.

[0167] In some examples, the first positioning portion 251 of the first base 25 can be a stepped structure protruding from the first base 25 along the central axis CA toward the distal end 102. The first driving portion 51 can be located in a groove-shaped space formed by the stepped structure and the sidewall of the second housing 30. In some examples, the first driving portion 51 can be sleeved around the outer periphery of the sidewall 22 of the moving body 20 and abut against the first positioning portion 251.

[0168] In some examples, the first positioning portion 251 can be cylindrical. In some examples, the first positioning portion 251 can be solid cylindrical, and the first driving portion 51 can be sleeved around the outer circumference of the first positioning portion 251. In other examples, the first positioning portion 251 can be hollow cylindrical, and the first driving portion 51 can be sleeved around the outer circumference of the first positioning portion 251 or embedded in the inner circumference of the first positioning portion 251.

[0169] In some examples, the first drive unit 51 can have an energy storage state and an energy release state. When the first drive unit 51 switches from the energy storage state to the energy release state, the first drive unit 51 can release energy and exert an action on the moving body 20 toward the proximal end 101. When the moving body 20 is held, the first drive unit 51 can exist between the moving body 20 and the first housing 10 in the energy storage state. When the moving body 20 is released, the first drive unit 51 can switch from the energy storage state to the energy release state and exert an action on the moving body 20 toward the proximal end 101.

[0170] In some examples, the first drive portion 51 may have a compressed state and an extended state, and when the first drive portion 51 switches from the compressed state to the extended state, the first drive portion 51 may release energy. In some examples, the first drive portion 51 may be an elastic element. In some examples, the two ends of the first drive portion 51 may abut against the first shell 10 and the first bottom 25, respectively. When the moving body 20 is retained in the first retaining portion 12, the first drive portion 51 may be in a compressed state. In this case, when the moving body 20 is released, the first drive portion 51 in the compressed state can automatically apply a force to the moving body 20 to achieve automatic pushing of the moving body 20, which is convenient for the operator to use. In some examples, the first drive portion 51 may be a spring.

[0171] In some examples, one end of the first driving part 51 can be sleeved on the first positioning part 251 of the first bottom part 25. In some examples, the first shell 10 can have a second positioning part 15 (see Figure 10). In some examples, the second positioning part 15 can be cylindrical. In this case, the other end of the first driving part 51 can be sleeved on the second positioning part 15. In some examples, the second positioning part 15 can be hollow cylindrical. In this case, the other end of the first driving part 51 can be sleeved on or embedded in the second positioning part 15. In some examples, the second positioning part 15 can be composed of at least two sections of arc columns. In this case, the other end of the first driving part 51 can be embedded between the arc columns.

[0172] In addition, the application device 100 of this embodiment is not limited thereto. In some examples, the application device 100 may also not include the first driving unit 51. In this case, when the moving body 20 is released, the moving body 20 can also be moved toward the proximal end 101 by manually applying an action on the moving body 20.

[0173] Figure 18 is a schematic diagram of a first perspective of the moving body 20 and the puncture member 40 involved in the example of the present disclosure; Figure 19 is a schematic diagram of a second perspective of the moving body 20 and the puncture member 40 involved in the example of the present disclosure; Figure 20 is a schematic cross-sectional view of the puncture member 40 involved in the example of the present disclosure when it is maintained.

[0174] In some examples, the moving body 20 and the piercing member 40 can be integrally fixedly connected. In other examples, the moving body 20 and the piercing member 40 can be detachably assembled and combined. In some examples, the piercing member 40 can be releasably retained by the moving body 20.

[0175] In some examples, the moving body 20 may include a hollow portion 26 (see FIG. 18 ). Specifically, the sidewalls 22 of the moving body 20 and the first bottom portion 25 of the moving body 20, facing the proximal end 101, may cooperate to form the hollow portion 26. In some examples, the piercing member 40 may be releasably disposed within the hollow portion 26 of the moving body 20. In some examples, the piercing member 40 may move along the hollow portion 26 of the moving body 20 when released. In this case, forming the hollow portion 26 by the first bottom portion 25 and the sidewalls, and positioning the receiving portion 21 at the first bottom portion 25 and the piercing member 40 at the hollow portion 26 facilitates movement of the piercing member 40 relative to the receiving portion 21 when released. Thus, when the monitoring device 800 is applied to a host, the piercing member 40 is released and moves relative to the receiving portion 21, thereby allowing the piercing member 40 to exit the host.

[0176] In some examples, the moving body 20 may include a second through hole 260 (see FIG. 19 ) connecting the receiving portion 21 and the hollow portion 26. In some examples, the puncture member 40 may contact the monitoring device 800 via the second through hole 260. This facilitates at least partial insertion of the monitoring device 800 into the subcutaneous tissue of the host via the puncture member 40 during application.

[0177] In other examples, the puncture member 40 may also be fixedly disposed on the moving body 20. In this case, after the monitoring device 800 is applied to the host, the moving body 20 can be completely separated from the host by manpower, thereby allowing the puncture member 40 to also separate from the host.

[0178] In some examples, the second driving unit 52 can be located between the moving body 20 and the piercing member 40. In some examples, the second driving unit 52 can be located between the first base 25 and the piercing member 40. The second driving unit 52 can be configured to apply force to the piercing member 40 toward the distal end 102. When the piercing member 40 is released, the second driving unit 52 can apply force to the piercing member 40 toward the distal end 102 to cause the piercing member 40 to exit the host. This can help more accurately control the timing of the piercing member 40's departure from the host.

[0179] In some examples, the second driving unit 52 may have an energy storage state and an energy release state. When the second driving unit 52 switches from the energy storage state to the energy release state, the second driving unit 52 may release energy and exert an action on the piercing member 40 toward the distal end 102. When the piercing member 40 is retained, the second driving unit 52 may be in the energy storage state and exist between the moving body 20 and the piercing member 40. When the piercing member 40 is released, the second driving unit 52 may switch from the energy storage state to the energy release state and exert an action on the piercing member 40 toward the distal end 102.

[0180] In some examples, the second driving portion 52 can have a compressed state and an extended state. When the second driving portion 52 switches from the compressed state to the extended state, the second driving portion 52 can release energy. In some examples, the second driving portion 52 can be an elastic element. In some examples, the two ends of the second driving portion 52 can abut the first base 25 and the piercing member 40, respectively. In other words, the two ends of the second driving portion 52 can abut the moving body 20 and the piercing member 40, respectively. When the piercing member 40 is retained, the second driving portion 52 can be in a compressed state. In this case, when the piercing member 40 is released, the compressed second driving portion 52 can automatically apply force to the piercing member 40, thereby automatically retracting the piercing member 40, thereby facilitating operation by the operator. In some examples, the second driving portion 52 can be a spring.

[0181] In some examples, as described above, the puncture member 40 may include a needle portion 41 and a carrier portion 42 connected to the needle portion 41 (see FIG. 18 ). In some examples, the needle portion 41 may be provided with a groove extending along the length of the needle portion 41. The sensor 8 may be at least partially disposed within the groove of the needle portion 41. In this case, the sensor 8 can be received within the groove, allowing the sensor 8 to follow the needle portion 41 and be placed subcutaneously within the host.

[0182] In some examples, the puncture member 40 may include a support base 43 (see FIG. 18 ) for supporting the needle portion 41 . The support base 43 may support the needle portion 41 via the bearing portion 42 .

[0183] In some examples, the support base 43 can be disposed within the hollow portion 26 of the moving body 20, and the bearing portion 42 and / or the needle-shaped portion 41 can pass through the second through-hole 260. In this case, by disposing the bearing portion 42 and / or the needle-shaped portion 41 through the second through-hole 260, the bearing portion 42 and / or the needle-shaped portion 41 can be engaged with the monitoring device 800 accommodated in the receiving portion 21, thereby facilitating the monitoring device 800 to be at least partially placed under the host's skin via the puncture member 40.

[0184] In some examples, the moving body 20 may include a third positioning portion 252 (see FIG. 18 ). The third positioning portion 252 may be used to position the second driving portion 52. In this case, the third positioning portion 252 can more stably define the position at which the second driving portion 52 applies force to the puncture member 40. In some examples, the third positioning portion 252 may be provided on the first base portion 25.

[0185] In some examples, one end of the second driving portion 52 can be nested within the third positioning portion 252 of the first base 25. In some examples, the third positioning portion 252 can be cylindrical. In this case, one end of the first driving portion 51 can be nested within the third positioning portion 252. In some examples, the puncture member 40 can have a fourth positioning portion 44 (see Figure 19). In some examples, the fourth positioning portion 44 can be a hollow cylindrical protrusion formed on the support seat 43. In this case, the end of the second driving portion 52 that contacts the puncture member 40 can be nested within or embedded in the fourth positioning portion 44. In some examples, the third positioning portion 252 and / or the fourth positioning portion 44 can be composed of at least two curved columns. In this case, the end of the first driving portion 51 can be nested between the curved columns.

[0186] In some examples, the needle portion 41 and the support base 43 can be integrally formed. In other examples, the needle portion 41 and the support base 43 can be configured to be detachably assembled and combined. This makes it easier to sterilize the needle portion 41 separately.

[0187] In some examples, a male-female mechanical mating structure may be provided on the inner wall of the moving body 20 and the outer wall of the piercing member 40. In some examples, the moving body 20 may include a fifth engagement feature 29, and the piercing member 40 may include a sixth engagement feature 46 (see Figures 18 and 19). The fifth engagement feature 29 and the sixth engagement feature 46 may cooperate to form a male-female mechanical mating structure. In some examples, the male-female mechanical mating structure may be a concave-convex mating structure. In some examples, the fifth engagement feature 29 may be one or more rib-shaped protrusions provided on the inner wall of the moving body 20, and the sixth engagement feature 46 may be one or more rib-shaped grooves provided on the outer wall of the piercing member 40 (see Figures 18 and 19). In some examples, when the piercing member 40 is assembled to the moving body 20, the one or more rib-shaped protrusions of the moving body 20 may respectively fit into the one or more rib-shaped grooves of the piercing member 40. In this case, on the one hand, the matching of the rib-shaped protrusions and the rib-shaped grooves facilitates the assembly of the moving body 20 and the piercing member 40; on the other hand, the rib-shaped protrusions and the rib-shaped grooves can guide the direction of relative movement of the piercing member 40 and the moving body 20; furthermore, the matching of the rib-shaped protrusions and the rib-shaped grooves can help prevent undesirable rotation of the piercing member 40. In some examples, the multiple rib-shaped protrusions provided on the inner wall of the moving body 20 can be evenly or symmetrically distributed on the inner wall of the moving body 20.

[0188] In some examples, as described above, the piercing member 40 can be releasably retained by the moving body 20. In some examples, the moving body 20 can include a second retaining portion 27 (see FIG. 18 ). The second retaining portion 27 can be configured to releasably retain the piercing member 40. In some examples, the second retaining portion 27 can be formed on the sidewall 22 of the moving body 20. In some examples, the second retaining portion 27 can be a cutout formed on the sidewall 22 of the moving body 20 (see FIG. 18 ).

[0189] In some examples, the piercing member 40 may include a second locking portion 45. The second locking portion 45 may be configured to releasably interlock with the second retaining portion 27. Thus, the piercing member 40 can be releasably retained in the second retaining portion 27 by the engagement of the second locking portion 45 with the second retaining portion 27. In some examples, the second locking portion 45 may be disposed on the support seat 43 of the piercing member 40.

[0190] In some examples, the second locking portion 45 may include an arm 450 extending generally along the direction of the central axis CA (hereinafter referred to as the fourth arm 450), and a protrusion 451 (hereinafter referred to as the fourth protrusion 451) that is linked to the fourth arm 450 and protrudes away from the central axis CA in a direction generally perpendicular to the central axis CA. In this case, when the puncture member 40 is placed in the hollow portion 26 of the moving body 20, the second locking portion 45 overlaps the cutout of the moving body 20, thereby retaining the puncture member 40 with a simplified structure.

[0191] In some examples, the fourth arm 450 can be elastic in a direction generally perpendicular to the central axis CA. In some examples, when the puncture member 40 is retained, the fourth protrusion 451 can pass through the notch. In this case, by overlapping the fourth protrusion 451 with the notch of the moving body 20, the second locking portion 45 can be retained while simplifying the structure.

[0192] In some examples, the second retaining portion 27 may include a first notch 271 and a second notch 272 (see FIG. 18 ) extending substantially along the central axis CA and communicating with each other. The first notch 271 may be located near the proximal end 101, and the second notch 272 may be located near the distal end 102. In some examples, the widths of the first notch 271 and the second notch 272 may differ. In some examples, the width of the first notch 271 may be greater than the width of the second notch 272.

[0193] In some examples, the first notch 271 may have a surface facing the proximal end 101. In some examples, the fourth protrusion 451 may have a surface facing the distal end 102. When the piercing member 40 is retained by the second retaining portion 27, the surface of the fourth protrusion 451 facing the distal end 102 overlaps the surface of the first notch 271 facing the proximal end 101.

[0194] In some examples, when an action is applied to the fourth arm 450 in a direction generally perpendicular to the central axis CA, the fourth arm 450 can pivot. For example, when an action is applied to the fourth arm 450 in a direction generally perpendicular to the central axis CA and toward the central axis CA, the fourth arm 450 can deflect, causing the end of the fourth arm 450 proximal to the distal end 102 to move toward the central axis CA. When the fourth arm 450 deflects toward the central axis CA until the second locking portion 45 separates from the second retaining portion 27, the piercing member 40 can be released. Thus, the piercing member 40 can be released easily and conveniently.

[0195] In some examples, when the piercing member 40 is released, the arms of the second locking portion 45 can be squeezed toward the central axis CA. This allows for easy release of the second locking portion 45. In some examples, the second retaining portion 27 and the second locking portion 45 can be releasably interlocked using at least one of a snap, hook, latch, or pin. This provides an interlocking mechanism that facilitates release.

[0196] In some examples, the second locking portion 45 of the piercing member 40 can be formed as a shoulder structure (see Figures 18, 19, and 20 in combination). In some examples, along the central axis CA and toward the distal end 102, the fourth arm 450 can gradually move away from the central axis CA. In some examples, when projected along the central axis CA, the projected surface of the fourth protrusion 451 and the projected surface of the first notch 271 can fully or partially overlap. In some examples, the number of second locking portions 45 can be one or more, such as one, two, three, or four. In some examples, the number of second locking portions 45 can be the same as the number of second retaining portions 27. In some examples, the width of the surface of the fourth protrusion 451 facing the distal end 102 can be less than the width of the first notch 271 and greater than the width of the second notch 272.

[0197] In some examples, the second housing 30 may include a second triggering portion 37 (see Figures 11, 16, and 20). The second triggering portion 37 can be configured to disengage the second retaining portion 27 from the second locking portion 45, thereby releasing the puncturing member 40. Thus, the second triggering portion 37 can facilitate the release of the movable body 20. In some examples, the second triggering portion 37 can apply force toward the central axis CA to the second locking portion 45, squeezing it inward and thereby separating it from the second retaining portion 27. In some examples, after the movable body 20 and the puncturing member 40 move toward the proximal end 101 to a predetermined position, the second locking portion 45 can disengage from the second retaining portion 27, thereby releasing the puncturing member 40. This allows for automatic triggering of the release of the puncturing member 40 after the movable body 20 and the puncturing member 40 reach the predetermined position, facilitating more precise control of the timing of the puncturing member 40's removal from the host. The predetermined position can be a location where the monitoring device 800 has been applied to the host's body surface. In some examples, the predetermined position may also be a position where the puncture member 40 has introduced the implanted portion 81 of the sensor 8 to a predetermined depth under the host's skin. That is, in some examples, the puncture member 40 may be configured to be released after moving a predetermined distance relative to the second housing 30.

[0198] In some examples, the second trigger portion 37 can be formed on the inner wall of the second housing 30. In some examples, the second trigger portion 37 can be a protrusion formed on the inner wall of the second housing 30 that protrudes toward the central axis CA in a direction substantially perpendicular to the central axis CA (hereinafter referred to as the fifth protrusion). When the moving body 20 and the piercing member 40 move relative to the second housing 30 (i.e., when the moving body 20 and the piercing member 40 move toward the proximal end 101), the second locking portion 45 first moves to a position that contacts the second trigger portion 37. As the moving body 20 and the piercing member 40 continue to move toward the proximal end 101, the fifth protrusion can abut against the fourth protrusion 451 and continuously apply force toward the central axis CA to the fourth protrusion 451. When the moving body 20 and the piercing member 40 move to a predetermined position, the fourth arm 450 retracts inward until the fourth protrusion 451 separates from the second retaining portion 27, thereby releasing the piercing member 40.

[0199] The following describes the interaction between the second retaining portion 27, the second locking portion 45, and the second triggering portion 37. When the piercing member 40 is retained by the second retaining portion 27, the second locking portion 45 contacts the second retaining portion 27, restricting its movement toward the distal end 102 and thereby retaining the piercing member 40 (see FIG. 20 ). As the moving body 20 and piercing member 40 move toward the proximal end 101, the second locking portion 45 first moves to a position of contact with the second triggering portion 37. As the moving body 20 and piercing member 40 continue to move toward the proximal end 101, the fifth protrusion abuts against the fourth protrusion 451 and continuously applies force toward the central axis CA. When the moving body 20 and piercing member 40 reach a predetermined position, the fourth arm 450 retracts inward until the fourth protrusion 451 separates from the second retaining portion 27, releasing the piercing member 40.

[0200] In some examples, after the piercing member 40 is released by the moving body 20, the second driving portion 52 drives the piercing member 40 toward the distal end 102, causing the piercing member 40 to exit the host. In some examples, the retracted piercing member 40 can be completely located within the interior space of the first housing 10. In this case, the sharp needle portion 41 can be prevented from being exposed to the outside of the application device 100, thereby improving the safety of the application device 100.

[0201] In some examples, as described above, the moving body 20 may include a housing 21. In some examples, the housing 21 may be disposed at an end of the moving body 20 facing the proximal end 101, and the entrance of the housing 21 may be oriented toward the proximal end 101 (see FIG. 19 ). In this case, it is possible to facilitate installation of the monitoring device 800 in the housing 21.

[0202] In some examples, the storage portion 21 may include a restraining portion 210 (see FIG. 19 ) for restraining the monitoring device 800. In this case, the restraining portion 210 restrains the monitoring device 800 contained in the storage portion 21, thereby more stably accommodating the monitoring device 800.

[0203] In some examples, the constraint portion 210 may include a constraint arm 211 and a protrusion 212 that approaches the central axis CA in a direction approximately orthogonal to the central axis CA (see Figure 19). The constraint arm 211 may extend in the direction of the central axis CA. In some examples, the constraint arm 211 may be elastic. In some examples, the constraint arm 211 may move toward the central axis CA. In this case, the constraint portion 210 can constrain the monitoring device 800 whose outline size is smaller than the storage portion 21. For example, the electronic component 9 of the monitoring device 800 can be embedded in the inner side of the storage portion 21, and an interference fit is formed between the constraint portion 210 and the housing 91 of the electronic component 9. In some examples, the number of the constraint portions 210 can be one or more, such as 1, 2, 3, or 4. In some examples, the constraint portions 210 can be evenly distributed along the periphery of the storage portion 21.

[0204] FIG. 21 is a schematic diagram illustrating a seal assembly 93 and an applicator cap 6 according to an example of the present disclosure.

[0205] In some examples, the applicator 100 may include an applicator cover 6 (see FIG. 9 ). In some examples, the applicator cover 6 may be detachably mounted on the first housing 10. When the applicator cover 6 is mounted on the first housing 10, the second housing 30 may be located in a sealed accommodation space formed by the applicator cover 6 and the first housing 10. In this case, the applicator cover 6 and the first housing 10 cooperate to form a sealed space to protect the internal structure, and the second housing 30 located in the sealed space can suppress the occurrence of undesired false touches, thereby improving the reliability of the applicator 100.

[0206] In some examples, the applicator cap 6 can be removed from the first housing 10 to put the applicator 100 in an applicable state. In some examples, as previously described, the monitoring device 800 can include a sealing assembly 93 that seals the sensor 8. In some examples, the applicator cap 6 can be removed from the first housing 10 and the sealing assembly 93 can be removed from the monitoring device 800 to put the applicator 100 in an applicable state.

[0207] In some examples, the applicator cap 6 and the first housing 10 can be threadedly connected. Specifically, the outer periphery of the end of the first housing 10 that is closest to the host can be provided with external threads, and the inner wall of the applicator cap 6 can be provided with internal threads that match the external threads. This facilitates assembly and disassembly of the applicator cap 6 and the first housing 10. In some examples, the applicator cap 6 can be rotated in a predetermined direction to be removed from the first housing 10, and can be rotated in a direction opposite to the predetermined direction to be assembled to the first housing 10. In some examples, the predetermined direction can be clockwise or counterclockwise.

[0208] In some examples, the sealing assembly 93 may include a first engagement feature 930, and the applicator cap 6 may include a second engagement feature 61 (see FIG. 21 ). The first engagement feature 930 cooperates with the second engagement feature 61 to allow the sealing assembly 93 to rotate with the applicator cap 6 when the applicator cap 6 rotates in a first direction, and the sealing assembly 93 to remain stationary when the applicator cap 6 rotates in a second direction opposite to the first direction. In this case, the sealing assembly 93 can be removed simultaneously with the applicator cap 6 being rotated in the first direction to remove the applicator cap 6, thereby facilitating use. Furthermore, during the assembly process of rotating the applicator cap 6 in the second direction to assemble the applicator cap 6 to the first housing 10, the sealing state of the sealing assembly 93 will not be affected, thereby facilitating factory assembly of the applicator 100 and the monitoring device 800.

[0209] FIG22 is a schematic diagram illustrating the structure of the inclined groove involved in an example of the present disclosure. FIG22 is a schematic diagram projected along the central axis CA of the applicator 100. To more clearly illustrate the cooperation between the sealing assembly 93 and the applicator cap 6, some components and lines that may cause obstruction or misunderstanding are omitted.

[0210] In some examples, the first engagement feature 930 can be an inclined groove formed on the side wall of the sealing assembly 93 (see Figure 22). The inclined groove can have a limiting surface 931 and an inclined surface 932 that transitions to the side wall of the sealing assembly 93, and the second engagement feature 61 can be a protrusion 62 (which can be called the sixth protrusion 62) that matches the inclined groove (see Figures 21 and 22). When the applicator cover 6 rotates in a first direction, the sixth protrusion 62 can abut against the limiting surface 931 so that the sealing assembly 93 rotates with the applicator cover 6; when the applicator cover 6 rotates in a second direction opposite to the first direction, the sixth protrusion 62 can slide along the inclined surface 932 and the outer periphery of the side wall of the sealing assembly 93. Thus, the first engagement feature 930 cooperates with the second engagement feature 61 to achieve the aforementioned preset function.

[0211] Refer to Figure 22. In the example of Figure 22, direction C1 schematically represents the clockwise direction, and direction C2 schematically represents the counterclockwise direction (i.e., the direction opposite to direction C1). When the applicator cover 6 rotates along direction C1, the sixth protrusion 62 of the applicator cover 6 can abut against the limiting surface 931. When the applicator cover 6 rotates along direction C2, the sixth protrusion 62 of the applicator cover 6 can slide along the outer periphery of the inclined surface 932 and the side wall of the sealing assembly 93.

[0212] In some examples, the applicator cap 6 may include a fourth restricting portion 63 (see FIG. 21 ). The fourth restricting portion 63 may restrict the position of the sealing assembly 93. In some examples, the fourth restricting portion 63 may restrict the sealing assembly 93 by surrounding the outer circumference of the sealing assembly 93. This may help prevent the sealing assembly 93 and the monitoring device 800 from undesirably shaking within the first housing 10. In some examples, the sealing assembly 93 may also be referred to as a sensor cap.

[0213] In some examples, the fourth limiting portion 63 may include an arm (which may be referred to as a fifth arm) extending in the direction of the central axis CA. In some examples, the second engagement feature 61 may be formed on the fourth limiting portion 63. This facilitates engagement of the second engagement feature 61 with the first engagement feature 930 when the sealing assembly 93 is restrained by the fourth limiting portion 63.

[0214] In some examples, after removing the applicator cap 6, the monitoring device 800 can be conveniently applied to the host using the applicator 100. In some examples, a desiccant can be placed in the sealed accommodation space formed by the applicator cap 6 and the first housing 10. This helps create a dry environment within the applicator 100, thereby facilitating the storage of the monitoring device 800.

[0215] Now, the application process of the application device 100 is described again: applying the monitoring device 800 to the host through the application device 100 may include an application phase and a withdrawal phase. In the application phase, the application device 100 may be applied to the host; in the withdrawal phase, the puncture member 40 may be removed from the host.

[0216] First, the applicator cap 6 is removed from the first housing 10 to put the application device 100 into an application-ready state.

[0217] During the application stage, the application device 100 is placed on the host's body surface, so that the proximal surface 31 of the second shell 30 contacts the host's body surface, and then the first shell 10 is pressed toward the host. When the first trigger part 33 moves to the first locking part 23, the first trigger part 33 actuates the first locking part 23 to pivot toward the direction close to the central axis CA, so that the first locking part 23 is separated from the first retaining part 12, thereby releasing the moving body 20; then, the first driving part 51 (or with the help of manpower) acts on the moving body 20 in a manner toward the proximal end 101, so that the moving body 20 and the puncture member 40 move toward the proximal end 101 together, and the monitoring device 800 located in the storage part 21 can be pushed to the host's body surface, and under the action of the puncture member 40, the sensor 8 is at least partially placed under the host's skin.

[0218] During the retraction stage, as the moving body 20 and the puncture member 40 move toward the proximal end 101, the second trigger portion 37 provided on the inner wall of the second shell 30 contacts the second locking portion 45 of the puncture member 40, and the second trigger portion 37 actuates the second locking portion 45 to deflect toward the direction close to the central axis CA, so that the second locking portion 45 is separated from the second retaining portion 27, thereby releasing the puncture member 40; then, the second driving portion 52 (or with the help of manpower) acts on the puncture member 40 in a manner toward the distal end 102, so that the puncture member 40 moves toward the distal end 102 and leaves the host.

[0219] Furthermore, it should be noted that during the withdrawal phase, the first driving portion 51 (or with the aid of human force) can still exert force on the moving body 20 toward the proximal end 101. In other words, for the first driving portion 51 configured as an elastic component (e.g., a spring), when the moving body 20 is driven toward the host and the monitoring device 800 housed in the storage portion 21 is applied to the host's body surface, the first driving portion 51 can still be in an energy storage state. In this case, during the withdrawal phase, the monitoring device 800 is tightly adhered to the host's body surface under the action of the first driving portion 51, thereby effectively reducing the possibility of the monitoring device 800 being separated from the host during the withdrawal phase due to the separation of the puncture member 40 and the sensor 8.

[0220] In summary, according to the present disclosure, an application device 100 and an analyte monitoring system 1000 can be provided that are easy to operate and can accurately apply the monitoring device 800 to a host.

[0221] Although the present disclosure has been described in detail above with reference to the accompanying drawings and embodiments, it will be understood that the above description does not limit the present disclosure in any form. Those skilled in the art may modify and change the present disclosure as needed without departing from the spirit and scope of the present disclosure, and such modifications and variations all fall within the scope of the present disclosure.

Claims

1. An application device for applying a monitoring device to a host, characterized in that: The application device includes a first housing, a second housing, a driving mechanism, a moving body, a puncture member provided on the moving body, and a proximal end close to the host and a distal end away from the host during operation. The first housing includes a first retaining portion for releasably retaining the moving body, and the second housing has a proximal surface that contacts the skin of the host during operation. The moving body includes a receiving portion for accommodating the monitoring device, and the puncture member is configured to at least partially introduce the monitoring device into the host's subcutaneous tissue. The first shell and the second shell move relative to each other in a manner of approaching each other to release the holding of the moving body by the first holding portion. After the moving body is released, it moves toward the proximal end together with the puncture member under the action of the driving mechanism to apply the monitoring device to the host and at least partially locate it under the host's skin.

2. The application device according to claim 1, characterized in that The moving body includes a first locking portion configured to be releasably interlocked with the first retaining portion, and the second housing includes a first triggering portion capable of separating the first retaining portion from the first locking portion to release the moving body.

3. The application device according to claim 2, characterized in that When the first housing and the second housing move relatively along the direction of the central axis of the applying device, the first triggering portion acts on the first locking portion to separate the first locking portion from the first retaining portion.

4. The application device according to claim 3, characterized in that The first retaining portion is a convex structure formed on the inner wall of the first shell. When the moving body is retained on the first retaining portion, the first locking portion engages with the convex structure; the first triggering portion deflects the first locking portion in a direction away from the first retaining portion to separate the first locking portion from the first retaining portion.

5. The application device according to claim 1 or 2, characterized in that The first housing includes a first restricting portion configured to inhibit the second housing from being detached from the first housing, and the second housing includes a first restricting portion coupled to the first restricting portion.

6. The application device according to claim 5, characterized in that The first shell includes a second limiting portion configured to inhibit the second shell from moving toward the proximal end. After the first shell and the second shell move relative to each other and release the moving body, the second shell is restricted by the second limiting portion.

7. The application device according to claim 6, characterized in that The first limiting portion and the second limiting portion are adjacently arranged in a direction along the central axis of the applying device, and the first limiting portion is configured to cooperate with the second limiting portion to hold the second shell.

8. The application device according to claim 1 or 2, characterized in that The driving mechanism includes a first driving part and a second driving part, and the moving body includes a second holding part that releasably holds the puncture member. After the moving body and the puncture member move toward the proximal end to a predetermined position under the action of the first driving part, the second holding part releases the puncture member, and the puncture member moves toward the distal end under the action of the second driving part.

9. The application device according to claim 8, characterized in that The first driving part is an elastic element, and two ends of the first driving part are respectively in contact with the first shell and the moving body. When the moving body is held by the first holding part, the first driving part is in a compressed state.

10. The application device according to claim 8, characterized in that The second driving part is an elastic element, and two ends of the second driving part are respectively in contact with the moving body and the puncture member. When the puncture member is held in the second holding part, the second driving part is in a compressed state.

11. The application device according to claim 1, characterized in that The application device includes an applicator cover detachably assembled to the first housing. When the applicator cover is assembled to the first housing, the second housing is located in a sealed accommodation space formed by the applicator cover and the first housing.

12. The application device according to claim 11, characterized in that The monitoring device includes a sensor that can be partially placed under the host's skin, an electronic component coupled to the sensor, and a sealing component that seals the sensor. The applicator cover is coupled to the sealing component. When the applicator cover is removed from the first shell, the sealing component is removed together with the applicator cover to enable the application device to be in an applicable state.

13. The application device according to claim 12, characterized in that The sealing assembly has a first engagement feature, and the applicator cover includes a second engagement feature. The first engagement feature cooperates with the second engagement feature so that the sealing assembly follows the applicator cover when the applicator cover rotates in a first direction, and the sealing assembly does not move when the applicator cover rotates in a second direction opposite to the first direction.

14. An analyte monitoring system, characterized in that The invention comprises the application device according to any one of claims 1 to 13, and a monitoring device.

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