System and method for identifying an abnormal perfusion pattern

Abstract

Abstract The present disclosure relates to systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. One embodiment relates to a computer implemented method for detecting (and / or identifying) one or more areas having an abnormal perfusion pattern in tissue of 5 a subject, for example during a medical procedure, the method comprising the steps of: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and / or controlled duration 10 between subsequent boluses, analysing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern. 15 5 15 20 26 20 49 37 25 J un 2 02 6 2 0 2 6 2 0 4 9 3 7 2 5 J u n 2 0 2 6 5 1 5

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