Antigen-binding molecule comprising altered antibody variable region

Abstract

[ABSTRACT] An antigen-binding molecule capable of binding to multiple different antigens (e.g., CD3 on T cells, and CD137 on T cells, NK cells, DC cells, and / or the like), but does not nonspecifically crosslink two or more immune cells such as T cells is provided. Such multispecific antigen- binding molecule is capable of modulating and / or activating an immune response while circumventing the cross-linking between different cells (e.g., different T cells) resulting from the binding of a conventional multispecific antigen-binding molecule to antigens expressed on the different cells, which is considered to be responsible for adverse reactions when the multispecific antigen-binding molecule is used as a drug. 20 26 20 79 52 21 J ul 2 02 6 2 0 2 6 2 0 7 9 5 2 2 1 J u l 2 0 2 6

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