Compound for the sequestration of undesirable antibodies in a patient

Abstract

Abstract The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( — S — P )(n-1) and a second peptide n-mer of the general formula P ( — S — P )(n-1); wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent. Abstract 20 26 21 08 74 03 A ug 2 02 6 2 0 2 6 2 1 0 8 7 4 0 3 A u g 2 0 2 6

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