Fusosome compositions and uses thereof

Abstract

The present disclosure provides, at least in part, methods and compositions for in vivo 5 fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell- specific regulatory element, and a non-target cell- specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome. 10 28925903.1:DCC-8 / 21 / 2026 5 20 26 22 03 17 21 A ug 2 02 6 2 8 9 2 5 9 0 3 . 1 : D C C - 8 / 2 1 / 2 0 2 6 2 1 A u g 2 0 2 6 5 2 0 2 6 2 2 0 3 1 7

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