Nucleic acids encoding a polypeptide comprising a modified Fc region of a human IgG1 and at least one heterologous antigen

Abstract

Abstract Nucleic acids and polypeptides encoded thereby The present invention relates to nucleic acids and peptides encoded by those nucleic acids. In 5 particular, the peptides comprise a modified IgG1 Fc region and one or more heterologous epitopes, which may be B- or T-cell epitopes. A nucleic acid of the invention may encode a polypeptide comprising: (i) a modified Fc region of a human IgG1, and (i) at least one heterologous antigen, wherein (a) the modified Fc region comprises at least the part of Fc that is capable of binding to CD64 and / or TRIM21, (b) at least one residue of the Fc region is modified to the corresponding 10 residue from a mouse IgG3 antibody and (c) the modified Fc region has enhanced avidity for Fc- gamma receptor (FcγR) when compared to the corresponding wildtype Fc region. Abstract 5 10 20 26 23 80 36 23 S ep 2 02 6 A b s t r a c t 2 0 2 6 2 3 8 0 3 6 2 3 2 0 2 6 S e p 1 0

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