Systems and methods for evaluating longitudinal biological feature data

Abstract

Systems and methods are provided for determining whether a test subject has a disease condition. In one aspect, the method includes determining at least first and second genotypic data constructs for a test subject, formed from data collected from first and second sample from the subject, respectively, at different times. The first and second genotypic data constructs are inputted into a model for the disease condition, thereby generating first and second model score sets for the disease condition, respectively. A test delta score set is determined based on a difference between the first and second model score sets. The test delta score set is evaluated against a plurality of reference delta score sets, to determine the disease condition of the test subject, where each reference delta score set is for a respective reference subject in a plurality of reference subjects. difference between the first and second model score sets. The test delta score set is evaluated 20 26 23 81 68 28 S ep 2 02 6 A B S T R A C T 2 0 2 6 2 3 8 1 6 8 2 8 S e p 2 0 2 6 d i f f e r e n c e b e t w e e n t h e f i r s t a n d s e c o n d m o d e l s c o r e s e t s . T h e t e s t d e l t a s c o r e s e t i s e v a l u a t e d

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