Pharmaceutical formulation 514

BNRE20170031BUndetermined Publication Date: 2009-10-05KUDOS PHARMACEUTICALS LIMITED
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Patent Information

Application Number
BNRE20170031
Authority / Receiving Office
BN · BN
Patent Type
Patents
Current Assignee / Owner
Priority Date
2008-10-07
Filing Date
2009-10-05
Publication Date
2009-10-05
Estimated Expiration
2029-10-05

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Abstract

The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H- phthalazin-1-one for increasing the bioavailability of the drug.
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