(THIO) carbamoyl-cyclohexane derivatives as d3 / d2 receptor antagonists

Abstract

The present invention relates to new D3 and D2 dopamine receptor subtype preferring ligands of formula (I): wherein R1 and R2 represent independently a substituent selected from hydrogen, alkyl, aryl, cycloalkyl, aroyl, or R1 and R2 may form a heterocyclic ring with the adjacent nitrogen atom; X represents an oxygen or sulphur atom; n is an integer of from 1 to 2, and / or geometric isomers and / or stereoisomers and / or diastereomers and / or salts and / or hydrates and / or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and / or prevention of a condition which requires modulation of dopamine receptors.