Pulmonary extracorporative illumination device for exciting photosensitive agents sensitive to infrared

Abstract

The present invention relates to a light-emitting device, adjustable to the human thorax, to be used for the eradication of microorganisms that cause pulmonary infections, in particular, for the eradication of bacteria that cause pneumonia, through the technique of photodynamic antimicrobial inactivation, in an extracorporeal manner, that is, non-invasive, in order to provide speed and better results in the treatment of such infections. This device contains light emitters that radiate infrared light, a system for fixing and adjusting to the body, and a system for controlling light irradiation.

Description

[001] The present invention falls within the field of medical optical instrumentation, in particular, a device with extracorporeal illumination for the eradication of microorganisms that cause pulmonary infections, more precisely in the inactivation of bacteria that cause pneumonia. Fundamentals of the invention:

[002] One of the newest advances in the treatment of different pathologies of bacterial, viral, fungal and inflammatory origin is the application of Photodynamic Therapy (PDT) with antimicrobial activity.

[003] Photodynamic Therapy (PDT) involves the use of a photosensitizing agent (PS) which, when activated by electromagnetic radiation (light) at a specific wavelength, is able to react with molecules in its vicinity through electron or hydrogen transfer mechanisms, leading to the formation of free radicals (type I reaction) or through an energy transfer mechanism interacting with molecular oxygen (type II reaction), leading to the production of singlet oxygen. Both highly cytotoxic reactions can lead to the death of tumor cells or the inactivation of microorganisms.

[004] There are many terms found in the literature to describe PDT, such as those from the English language: PACT (Photodynamic Antimicrobial Chemotherapy), PDT (Photodynamic Therapy), PAD Petition 870260055210, dated 08 / 06 / 2026, page 7 / 39 2 / 19 (Photoactivated Disinfection), PDD (Photodynamic Disinfection), PDI (Photodynamic Inactivation), aPDT (Antibacterial Photodynamic Therapy), among others.

[005] Antimicrobial photodynamic therapy (PDT), better described by the term: Photodynamic Inactivation (PDI) (since the term PDT is more widely used when the therapeutic targets are mammalian and tumor cells) refers to the photodynamic inactivation of microorganisms, presenting a great advantage when compared to the use of antimicrobial agents, since it is highly unlikely that microorganisms will exhibit resistance to this technique.

[006] The IFD of microorganisms is based on the preferential accumulation of the photosensitizing agent (PS) in the therapeutic target, such as bacteria, and not in the surrounding cells or tissues. This condition is essential so that, when subsequently activated by low doses of light, no toxic effect occurs on the host cells.

[007] Pneumonia is defined as acute inflammation of the lung parenchyma structures that can be caused by different etiological agents (bacteria, viruses, atypical organisms, and fungi). Initially, it presents as a colonization of the nasopharyngeal mucosa, subsequently spreading to the lower respiratory tract. The infection can be community-acquired (CAP) or hospital-acquired, the latter often being called nosocomial pneumonia.

[008] Thus, hospital-acquired infections are a concern because they can lead to the occurrence or worsening of pre-existing pneumonia. Hospital-acquired infection is defined Petition 870260055210, dated 08 / 06 / 2026, page 8 / 39 3 / 19 defines any infection diagnosed more than forty-eight hours after the patient's admission to the hospital, without being in the incubation period during this time or after hospital discharge, and which may be related to hospitalization or hospital procedures.

[009] In developing countries, the main causative agents of pneumonia are bacteria, and microbiological studies indicate that Streptococcus pneumoniae is the microorganism responsible for 30-50% of cases. The second most common agent is Haemophilus influenzae type b (Hib), followed by Staphylococcus aureus and Klebsiella pneumoniae.

[0010] Given the severity of bacterial pneumonias and the increase in infections caused by antibiotic-resistant bacteria, there is a need for alternative or combined treatments to enhance treatment effectiveness and, consequently, therapeutic success, reducing morbidity and mortality.

[0011] IFD with indocyanine green (ICV, a photosensitizer used in preliminary animal tests) represents a major advance in the treatment of pulmonary infections. This compound, when activated, induces a cytotoxic reaction by forming reactive oxygen species, mainly singlet oxygen, inactivating bacteria that cause pulmonary infections (pneumonia). There is also evidence in the literature of the inactivation of fungi, such as Candida albicans and Trichophyton rubrum, using IFD with ICV as a photosensitizer. Thus, ICV is promising not only for bacterial pneumonias, but also for those of other etiologies. Petition 870260055210, dated 08 / 06 / 2026, page 9 / 39 4 / 19

[0012] Other photosensitizers used in Photodynamic therapy (chlorine and bacteriochlorine derivatives) could also be used, as they have the ability to be activated at the wavelength necessary to reach the lungs. However, only ICV (intravascular coagulation) has, to date, all the necessary tests and approvals for clinical use.

[0013] The main advantage associated with equipment that uses lasers and / or light-emitting diodes (LEDs) emitting in the infrared region is the possibility of extracorporeal illumination, making the treatment non-invasive, since the longer the wavelength, the greater the light penetration into the skin.

[0014] The relationship between wavelength and tissue penetration in biological media is known; and, for treatments that require penetration between the layers of skin, muscles and bones, only those belonging to the range between 600 and 1200nm are able to reach the target, which in this proposal are the lungs.

[0015] Near-infrared light (600-2500nm) penetrates biological tissues, such as skin and blood, more efficiently than visible light because these tissues scatter and absorb less light at longer wavelengths.

[0016] In addition to the choice of light source (LEDs and Lasers with Infrared emission), the photosensitizer is essential for the photodynamic reaction to occur for the selective destruction of bacteria present in the lung. Indocyanine Green (ICG) is a photosensitizer of choice for activation in the region of Petition 870260055210, dated 08 / 06 / 2026, page 10 / 39 5 / 19 Infrared, due to its high absorption in this region, being a drug approved by the FDA (Food and Drug Administration, in the United States) and ANVISA (National Health Surveillance Agency, in Brazil), being a safe compound for the patient and widely used in clinical practice and in Photodynamic Inactivation studies.

[0017] The use of infrared light is already known in the medical, dental, aesthetic, and other fields, being used for everything from pain relief to rejuvenation and treatment of skin infections. The advantage of infrared light is the low interaction of this electromagnetic radiation with biological tissue, which increases therapeutic specificity.

[0018] In relation to prior art, laser and LED-based infrared light equipment is available for pain treatment in physiotherapy, as well as for weight loss, cellulite, and localized fat reduction. However, devices for photodynamic therapy for the purpose proposed in the present invention, possessing the innovative characteristics that have been technically programmed and will be described in detail below, are not available in the state of the art. In short, the arrangement of light emitters presenting a larger illumination area and the arrangement of a certain number of emitters proposed by the present invention are technically programmed to be able to optimize and enable the photodynamic response in the thoracic cavity. State of the art:

[0019] Document RU2376045, “METHOD FOR TREATMENT Petition 870260055210, dated 08 / 06 / 2026, page 11 / 39 6 / 19The document "OF PNEUMONIA" describes a device that treats pneumonia with infrared radiation. More specifically, for the prototype device depicted in the invention, the pneumonia treatment method involves subjecting the patient to multiple transcutaneous sessions of infrared laser radiation. The distinction between the aforementioned document and the present invention lies mainly in the category of the proposal – since the present invention claims a device, while the document presents a treatment method. Furthermore, the present invention differs from document RU2376045 regarding the mechanism of action of the techniques for treating patients.While document RU2376045 uses phototherapy, a technique that utilizes the interaction of light with biological tissues to promote therapeutic action, the present invention applies to the field of photodynamic therapy, which consists of the interaction of light with a photoactive substance, in the presence of oxygen, to promote therapeutic action. Finally, the aforementioned document RU2376045 mentions a prototype that comprises the use of low-intensity pulsed infrared laser, while the present invention comprises the development of a new device, constructed with LEDs or infrared lasers, whose constructive form enables the irradiation of the entire thoracic region, being designed to be easily adaptable to the patient's anatomy. The physical structures, as well as the electronic components, are defined according to the optical designs of the system.

[0020] Document US5616140A, “METHOD AND APPARATUS "FOR THERAPEUTIC LASER TREATMENT," displays a device. Petition 870260055210, dated 08 / 06 / 2026, page 12 / 39 7 / 19 portable photodynamic therapy device with hyper-red light-emitting diodes, which is adaptable to specific parts of the body where the patient undergoes therapy. Thus, the main difference between the equipment proposed in the document and the present invention is that the object of protection of document US5616140A is a system not specific to the thoracic region, and it only provides phototherapy for the treatment of conditions for which low-power laser energy has already been effective, such as accelerating the healing process, controlling pain, stimulating nerves, reducing edema, etc. It is also important to emphasize that the equipment does not activate any photosensitive compound, which differentiates it from the equipment disclosed in the present invention, both in conformation and utility.

[0021] Document US8585707B2, “CONTINUOUS LOW IRRADIANCE PHOTODYNAMIC THERAPY METHOD”, describes a photodynamic therapy method that uses continuous low-irradiance radiation applied through a device adaptable to the body surface using a type of fiber optic fabric that serves as a malleable light source. The document mentions some photosensitizers, not including indocyanine green, and presents some constructive forms, none of which would be specifically suitable for the thoracic region, nor could they be fully adapted to the anatomy of that region. Thus, it is concluded, as an additional difference, that the proposal of document US8585707B2 would not address the treatment of pneumonia, as claimed in the present invention. Furthermore, the document does not consider its use / application for the purpose proposed in the present invention. Petition 870260055210, dated 08 / 06 / 2026, p. 13 / 39 8 / 19 invention.

[0022] The article entitled “Photodynamic inactivation of microorganisms which cause pulmonary diseases with infrared light: an in vitro study” describes an evaluation of the interaction of a photosensitizer activated by infrared light and its effectiveness in relation to photodynamic therapy for the treatment of pulmonary diseases. The article describes a photodynamic therapy methodology for in vitro inactivation of Streptococcus pneumoniae, using an 850nm LED system. Thus, the distinction between the article and the proposal of the present invention lies initially in the application of the equipment described in the documents, since the equipment in the article was used for in vitro studies in order to obtain a proof of principle of photodynamic therapy with the photosensitizer indocyanine green to inactivate microorganisms, and the equipment of the present invention aims at extracorporeal pulmonary illumination.It is important to emphasize that, to propose new treatments, proof of principle in in vitro and in vivo models is fundamental to guarantee both the therapeutic efficiency and the safety of the new technique or substance. The parameters and illumination geometry of the device used in in vitro experiments are very different from the system described in the current application, since application in a human patient requires a different optical and mechanical geometry, as well as different electronics for the electrical power supply of the light emitters. The resulting irradiation from the two systems is especially different considering the illumination area and irradiance. Furthermore, another difference between the techniques is that... Petition 870260055210, dated 08 / 06 / 2026, page 14 / 39 The equipment used in this article was constructed with 24 850nm LEDs, with an intensity of 30mW / cm², arranged on a rigid plane, fixed to its own base with a ventilation system, in order to irradiate 24-well plates homogeneously. The total illumination area of ​​the equipment for illuminating cell samples is 10 cm x 15 cm, which is insufficient to illuminate half of the human rib cage. Furthermore, the illumination of the cell culture plates does not take into account the curvature of the rib cage, since the illumination is uniform across the plane. In contrast, the equipment proposed in this invention comprises the use of LEDs or lasers in a flexible blanket large enough to completely irradiate the human rib cage. In this regard, it should also be noted that the flexibility characteristics of the blanket require a complete alteration in the construction of the device so that it adapts perfectly to different anatomical profiles.

[0023] The article entitled, “Pneumonia treatment by photodynamic therapy with extracorporeal illumination - an experimental model”, presents a study on a method, model, and results of extracorporeal photodynamic therapy in the treatment of pneumonia in rodents. More specifically, it studies the effectiveness of inactivating Streptococcus pneumoniae using indocyanine green (ICG or ICV) combined with infrared radiation light emission. It consists of a preclinical study conducted as proof of principle of infrared photodynamic therapy using indocyanine green as a photosensitizer, essential to ensure the safety and efficacy of the treatment. In particular, for photodynamic therapy, the light source is critical for the Petition 870260055210, dated 08 / 06 / 2026, page 15 / 39 10 / 19 treatment success, making this study crucial by demonstrating that the prototype is capable of exciting indocyanine, causing a reduction in the bacterial load in the lungs of animals. Thus, the article in question contains important evaluations that support the proposal of equipment aimed at treating pneumonia through extracorporeal pulmonary illumination, providing strong evidence that the equipment will be able to fulfill its purpose. The distinction between the aforementioned article and the proposal of the present invention lies in the application of the equipment, since the prototype presented in the article was used for the illumination of mice, presenting different conformity and power than the equipment proposed here, with the aforementioned disclosure being used only for proof of principle. The direct transposition of the in vitro results to clinical illumination parameters cannot be performed by any means.Thus, a study to characterize the distribution of light in the tissue from extracorporeal illumination was necessary for the optical and mechanical design of the system described herein. The equipment of the present invention aims at extracorporeal pulmonary illumination of humans, and the mechanical, optical, and electrical characteristics of the equipment are examined. In the article, a prototype composed of 18 780nm lasers, with an intensity of 60 mW / cm2 positioned in an arc-shaped structure, suitable for the homogeneous irradiation of the thoracic region of animals, is studied, while in the present invention, equipment constructed with LEDs or lasers in a flexible blanket of sufficient size to completely irradiate the rib cage is claimed. Petition 870260055210, dated 08 / 06 / 2026, page 16 / 39 11 / 19 human, observing the necessary safety standards for the construction of equipment that will be used in the healthcare field. The equipment in the document was used as proof of principle to demonstrate the feasibility of the technique and to ensure it resulted in equipment for human use.

[0024] The article entitled “Pulmonary decontamination for photodynamic inactivation with extracorporeal illumination” describes the development of a device to implement photodynamic inactivation for the treatment of pulmonary diseases using extracorporeal illumination. The article also mentions a positive alert regarding the use of extracorporeal illumination for photodynamic therapy with the specific application of an infrared light source. The article describes the use of a commercial irradiation source, emitting 810 nm, to observe the propagation of light in a liquid phantom model (which mimics the interaction of light with biological tissue) and in the body of an euthanized mouse, to determine if the studied wavelength would be able to reach its lung. No studies of photodynamic therapy or studies with live, contaminated animals are presented; only data on light transmittance in different systems are included.Thus, the distinction between the article and the present invention lies in the equipment itself, since the system presented in the article is a commercial low-intensity infrared system with a limited irradiation area. Another point of difference is that the application of the equipment in the article is directed to a light source used on a euthanized animal, aiming to evaluate the penetration capacity of infrared radiation. Meanwhile, the equipment in the... Petition 870260055210, dated 08 / 06 / 2026, page 17 / 39 12 / 19 The present invention aims at extracorporeal pulmonary illumination in humans for the treatment of pneumonia by photodynamic therapy. Advantages of the Invention

[0025] Seeking to solve the deficiencies of the prior art, the present invention discloses a device based on lasers or light-emitting diodes (LEDs), which operate at wavelengths in the near-infrared range of 600 to 2500 nm, for use with photosensitizing agents activated in these regions of the spectrum, acting on the photodynamic inactivation of microorganisms that cause pulmonary infections, in particular, for the inactivation of bacteria that cause pneumonia. The equipment of the present invention has characteristics of flexibility, which makes it possible to adapt anatomically to the patient's body, in addition to covering the entire thoracic region. One of the most relevant results evidenced with the use of the present invention is that the device disclosed here, in association with photosensitizing agents, presents a beneficial effect, as it potentiates antimicrobial photodynamic therapy. Brief description of the invention:

[0026] The present invention relates to a light-emitting device, adjustable to the human thorax, to be used in the treatment of microorganisms that cause pulmonary infections (pneumonia), in particular bacteria, by means of the extracorporeal, i.e., non-invasive, antimicrobial photodynamic inactivation technique, in order to provide speed and better results in treatment. Petition 870260055210, dated 08 / 06 / 2026, page 18 / 39 13 / 19

[0027] This device contains light emitters that radiate infrared light, a mechanism for attaching and adjusting to the body, and a mechanism for controlling light irradiation. Brief description of the figures:

[0028] To obtain a full and complete visualization of the object of this invention, the figures to which reference is made are presented, as follows.

[0029] Figure 1 shows a perspective view of the device.

[0030] Figure 2 shows a front view of the device.

[0031] Figure 3 shows a side view of the device.

[0032] Figure 4 shows a perspective view of the device properly assembled for use.

[0033] Figure 5 shows the dynamics between voltage and tension, electronic board, display and buttons.

[0034] Figure 6 illustrates the steps of pulmonary disinfection caused by microorganisms, in this case, bacteria, through photodynamic therapy, using the extracorporeal illumination device of the present invention.

[0035] Figure 7 shows an example of the positioning of the extracorporeal lighting device of the present invention on the patient's body. Detailed description of the invention:

[0036] The present invention relates to an extracorporeal pulmonary illumination device, which in conjunction with photosensitizing agents (PS), such as indocyanine green, bacteriochlorine, PS bound to nanoparticles, PS derived from chlorines and other PS with Petition 870260055210, dated 08 / 06 / 2026, page 19 / 39 14 / 19 infrared excitation, or those activated by two photons, is capable of enhancing antimicrobial photodynamic therapy in the treatment of microorganisms that cause lung infections, especially in the treatment of pneumonia caused by bacteria.

[0037] The aforementioned equipment is presented as a versatile device to be used in photodynamic inactivation, exhibiting such flexibility that it allows for anatomical adaptation to the patient's body. Especially due to this characteristic, the equipment illuminates the entire thoracic area of ​​the patient, and, for this reason, it is preferably manufactured in malleable material for a perfect fit on different body types.

[0038] The present invention comprises, therefore: - a blanket (1); - heat sinks (2); - light emitters (3); - two fastening pieces (4); - two strips (5); - a cable (6); - a cabinet (7); - a display (8); - parameterization buttons (9); - button to activate the emitters (10); - voltage source (11); - metal structure (12); - voltage source board (13); - electronic board (14); - on / off button (15).

[0039] The blanket (1) is preferably made Petition 870260055210, dated 08 / 06 / 2026, page 20 / 39 15 / 19 in ethylene vinyl acetate, silicone or other material rigid enough to fix the light emitters (3), and flexible enough to conform to the patient's body.

[0040] In the blanket (1) the light emitters (3) are arranged in a rectangular and uniform manner in order to better position the light rays.

[0041] The preferred dimensions of the blanket (1) are in the range of 200 to 400 mm in width, 200 to 900 mm in length and 10 to 20 mm in height, depending on the size of the patient to be treated. Figures 1 to 4 help visualize the components and characteristics of the blanket (1).

[0042] The present invention provides that the blanket (1) may optionally be coupled to a metal structure (12) in order to assist in its positioning and stabilization. This metal structure, if used, shall have dimensions in the range of 200 to 400 mm in width, 200 to 900 mm in length and 15 mm in height, optionally varying between 10 and 100 mm in its dimensions. Figures 4 and 7 help visualize the blanket (1) with the use of this metal structure (12).

[0043] The heat sinks (2), in turn, have preferred dimensions of 15 to 25 mm in diameter and 10 to 20 mm in length, which optionally vary according to the size of the light emitter (3). The heat sinks (2) are coupled to the blanket (1) and to the light emitters (3) and arranged between them at a distance of 25 to 90 mm, with the purpose of dissipating the heat produced by the light emitters (3).

[0044] The light emitters (3) operate in the infrared range, between 600 and 2500nm of the spectrum Petition 870260055210, dated 08 / 06 / 2026, page 21 / 39 16 / 19 electromagnetic, and with illumination intensity between 10 and 1200mW / cm2, with illumination doses varying between 4 and 150J / cm2. The light emitters (3) are preferably lasers, light-emitting diodes (LEDs), optionally another light emitter that radiates in the range of the magnetic spectrum mentioned above.

[0045] That being said, it must be understood that the blanket (1), the heat sinks (2) and the light emitters (3) form the flexible part of the device, which comes into contact with and fits into the back of the patient, from where the light must be irradiated for the photodynamic inactivation of bacteria that cause lung infections.

[0046] To stabilize the device to the patient's body, two strips (5) parallel to each other are adapted to the blanket (1) that surrounds it. These strips (5) are in the form of a belt, a ribbon or other object that performs this function.

[0047] The two fastening pieces (4) are responsible for establishing the proper adjustment of the straps (5) to the patient's body. For this reason, they are arranged one on each strap (5). The fastening pieces (4) are in the form of a clip, a buckle, Velcro or other device that performs this function.

[0048] The cable (6) has the function of electrically supplying the light emitters (3), according to the parameters selected on the display (8).

[0049] The voltage source (13) has the function of supplying electrical power to the light emitters (3) and the electronic board (14), where the irradiation parameters are controlled. A voltage between 90V and 300V is required. Petition 870260055210, dated 08 / 06 / 2026, page 22 / 39 17 / 19 a current between 100mA and 700mA to power the light emitters (11), with the voltage and current values ​​depending directly on the irradiation parameters selected by the operator.

[0050] The display (8) has the function of presenting to the device operator, who would preferably be a healthcare professional, the parameters for selecting: power, light intensity, light dose and available operating times.

[0051] The parameterization buttons (9) are intended to allow the operator to select the light emitters (3) that will operate, the irradiation power and the operating time. This makes it possible to adjust the light irradiation according to the needs of each patient, in an individual, specific and simplified way.

[0052] The transmitter activation button (10) has the function of simply activating the device. And with the same activation function, the on / off button (15) has the function of connecting the device to the electrical network. Figure 5 helps visualize this part of the device.

[0053] The electronic board (14) is made of fibrous material, preferably phenolic resin, fiberglass, polyester film or other polymer, and is provided with metallic films, preferably copper, silver, gold or nickel. To maintain the portability characteristics of the equipment, the electronic board (11) has dimensions in the range of 80 to 180 mm in length and 30 to 130 mm in width.

[0054] The electronic board (14) controls the operation of the device, receiving radiation intensity information, which is selected by the operator. Petition 870260055210, dated 08 / 06 / 2026, page 23 / 39 18 / 19 on the parameterization buttons (9). In addition, it performs the communication that allows the display of the parameters on the display (8). Based on the information selected by the operator, the electronic board (14) selects the supply voltage and current parameters and waits for the button (10) to be pressed to start the device's operation. This adjustment is done electronically and automatically, via an electronically programmable control device, contained in the aforementioned electronic board (14).

[0055] For a complete understanding of the present invention, the operation of the device is described in the following steps: 1- Start of operation

[0056] Initially, the equipment is connected to the power outlet, followed by pressing the on / off button (15) to turn the device on; 2- Light distribution

[0057] Immediately after the voltage source (13) is energized, the voltage is controlled and distributed appropriately to the light emitters (3) by the electronic board (14). As mentioned earlier, this regulation is done electronically and automatically via an electronically programmable control device, contained in the electronic board (14), according to the power of the light emitters (3). 3- Parameter selection

[0058] The desired parameters are selected via button (9) and will be visible on the display (8) for lighting the light emitters (3) together.

[0059] Through laboratory tests on animals Petition 870260055210, dated 08 / 06 / 2026, page 24 / 39 In the 19 / 19 (mice) test, it was possible to verify bacterial reduction, or a reduction in the number of colony-forming units per milliliter (CFU / mL) in the animals' lungs. Indocyanine green (ICG) was used as a photosensitizer and light with a wavelength of 780 nm for in vivo photodynamic inactivation (PDI). The parameters used proved efficient, with significant inactivation of the microorganism causing the infection, resulting in the cure of 80% of the infected animals (mice) treated with PDI. In this experiment, ICG was used at a concentration of 100 μM instilled and a light dose of 120 J / cm². Figure 6 illustrates the steps for eradicating microorganisms in the lung, in this case, inactivating bacteria, through photodynamic therapy, using the extracorporeal illumination device of the present invention and indocyanine green as a photosensitizer.

[0060] In the first stage, the FS is inhaled, followed by irradiation with the proposed extracorporeal illumination equipment, and finally, the treated individual can be evaluated.

[0061] Those skilled in the art will appreciate the knowledge presented here and will be able to reproduce the invention in the forms presented and in other variants, covered within the scope of the appended claims.

Claims

1. Pulmonary extracorporeal illumination device for excitation of infrared-sensitive photosensitizing agents directed to antimicrobial photodynamic therapy characterized by comprising: a flexible blanket (1) that is anatomically adaptable to the patient's body, wherein said blanket has preferred dimensions in the range of 200 to 400 mm in width, 200 to 900 mm in length and 10 to 20 mm in height; dissipators (2), wherein said dissipators have preferred dimensions of 15 to 25 mm in diameter and 10 to 20 mm in length, varying according to the size of the light emitter (3) and arranged between each other at a distance of between 25 and 90 mm; light emitters (3) operating in the infrared range, between 600 and 1200nm of the electromagnetic spectrum, and with illumination intensity between 10 and 1200mW / cm2, with illumination doses varying between 4 and 150 J / cm2;metal structure (12), wherein said metal structure has dimensions in the range of 200 to 400mm in width, 200 to 900mm in length and 10 to 20mm in height; two fastening pieces (4); two strips (5).; 2. Device, according to claim 1, characterized in that it further comprises: a power cable (6); a housing (7); a display (8); parameterization buttons (9) selecting the irradiation power and operating time of the light emitters (3); emitter activation button (10); voltage source (11); voltage source board (13); electronic board (14); on / off button (15).

3. Device according to claim 1, characterized in that the photosensitizing agents (PS) are preferably indocyanine green, bacteriochlorine, chlorine derivatives or other photosensitizer with infrared excitation.

4. Device according to claim 1, characterized in that the blanket (1) is preferably made of ethylene vinyl acetate, silicone or other material rigid enough to fix the light emitters (3), and flexible enough to adapt to the patient's body.

5. Device, according to claim 1 or 3, characterized in that the blanket (1) is further attached to a metal structure (12) for positioning and stabilizing the patient's body.

6. Device according to claim 1, characterized in that the heat sinks (2) are coupled to the blanket (1) and to the light emitters (3).

7. Device according to claim 1, characterized in that the light emitters (3) are lasers or light-emitting diodes arranged in the blanket (1) in a rectangular and uniform shape.

8. Device, according to claim 1, Petition 870260055210, dated 08 / 06 / 2026, page 27 / 39 3 / 3 characterized by the fact that the strips (5) are fixed to the blanket (1), parallel to each other, preferably in the form of a belt or ribbon.

9. Device according to claim 1 or 8, characterized in that the fastening parts (4) are arranged one on each strip (5), having the form of a clip, buckle or Velcro.

10. Device, according to claim 1 or 2, characterized in that the voltage source (13) has a voltage ranging from 90V to 300V and a current between 100mA and 700mA, according to what meets the power of the light emitters (3).

11. Device, according to claim 1 or 2, characterized in that the electronic board (14) is made of fibrous material, preferably phenolic resin, fiberglass, polyester film or other polymer, and provided with metallic films, preferably copper, silver, gold or nickel, having dimensions in the range of 80 to 180 mm in length and 30 to 130 mm in width.

12. Device according to claim 11, characterized in that the electronic board (14) selects the supply voltage and current parameters electronically and automatically via an electronically programmable control device contained in said electronic board (14).

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