VHH-BASED NKP46 LIGANDS

VHH antibody domains with high affinity for NKp46 enhance NK cell activation and cytotoxicity, addressing the limitations of existing ligands by improving specificity, stability, and manufacturability, effectively targeting tumor cells.

BR112025016337A2Pending Publication Date: 2026-07-07MERCK PATENT GMBH
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Patent Information

Application Number
BR112025016337
Authority / Receiving Office
BR · BR
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-02-06
Filing Date
2024-02-05
Publication Date
2026-07-07

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Abstract

The present disclosure relates to VHH-based NKp46 binders with favorable characteristics. Moreover, the present disclosure relates to pharmaceutical compositions comprising such a compound and the use of such compounds and such pharmaceutical compositions in medical treatment methods.
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