COMPOSIÇÕES DE HIGIENE PESSOAL

Abstract

Personal care compositions formulated to preserve pigment associated with a skin tattoo, to improve the health skin, and / or to improve the appearance of skin are disclosed herein. The personal care compositions comprise one or more vitamin E and one or more vitamin B comprising niacinamide and / or one or more vitamin C comprising ascorbyl phosphate.

Description

1 / 51 Personal Hygiene Compositions - Cross-reference to Related Orders

[0001] This application claims the benefit of priority of U.S. Patent Application No. 63 / 493,475, filed March 31, 2023, entitled Personal Care Compositions, the contents of which are incorporated herein in full for all purposes. FOUNDATION

[0002] A tattoo is a body modification made by inserting ink into the skin or other areas. The tattooing process involves placing pigment into the skin. After the initial injection, the pigment is dispersed through a homogenized layer of the epidermis and upper dermis, and in both, the presence of extracellular matrix (extracellular matrix) continues to bind the pigment particles. The epidermis repairs the upper dermis, where the pigment penetrates just below the dermis / epidermis junction.

[0003] Although the pigment remains trapped within the fibroblasts, it can degrade over time in certain areas. SU

[0004] This summary is intended merely to introduce a summary of this disclosure. Other areas of applicability of this disclosure will become apparent from the detailed description provided. Petition 870250084774, dated 09 / 19 / 2025, page 18 / 82 2 / 51 to follow. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to outline the scope of the disclosure. Instead, its purpose is merely to introduce a detailed description that follows.

[0005] Aspects of the present invention are directed to personal hygiene products formulated to preserve the pigment associated with a tattoo and the appearance of the skin. According to one aspect of the invention, approximately 5 to 10% by weight of one or more B vitamins comprising niacinamide is provided, and co

[0006] According to another aspect of the invention, a 5% ascorbyl content is provided, wherein all percentages by weight are based on the total weight of the content.

[0007] A list of examples of non-limiting modalities is provided below:

[0008] According to modality 1, a personal hygiene composition is provided comprising: uu of about 0.01 to about 5% by weight of one or more vitamins E, Petition 870250084774, dated 09 / 19 / 2025, p. 19 / 82 3 / 51 of about 0.01 to about 7% by weight of one or more B vitamins comprising niacinamide; and from co

[0009] According to embodiment 2, a personal hygiene composition is provided comprising: uu of about 0.01 to about 5% by weight of one or more vitamins C, C and of the co

[0010] According to embodiment 3, a personal hygiene composition is provided according to what is used of vitamin E, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, tocopherol acetate, tocopherol phosphate or any combination thereof.

[0011] According to embodiment 4, a composition for personal hygiene is provided in accordance with any previous embodiment, in which one or more vitamin E products comprise an alpha-tocopherol and vitamin E acetate.

[0012] According to modality 5, a personal hygiene composition is provided according to the personal hygiene te vita

[0013] According to modality 6, a personal hygiene composition is provided in accordance with Petition 870250084774, dated 09 / 19 / 2025, page 20 / 82 The ratio of 4 / 51 by weight of the total amount of vitamin E to niacinamide is approximately 1:1 to approximately 1:3.

[0014] According to embodiment 7, a personal hygiene composition is provided according to embodiment 2, wherein the personal hygiene composition has a weight ratio of the total amount of vitamin E to ascorbyl phosphate of about 14:1 to about 1:2.

[0015] According to embodiment 8, a composition for personal hygiene is provided according to the weight of the total amount of vitamin E to ascorbyl phosphate is about 7:1 to about 3:1.

[0016] According to modality 9, a personal hygiene composition is provided according to lactic acid and / or a salt thereof.

[0017] According to modality 10, a personal hygiene composition is provided in accordance with co

[0018] According to modality 11, a personal hygiene composition is provided in accordance with co

[0019] According to embodiment 12, a composition for personal hygiene is provided according to the surfactants.

[0020] According to embodiment 13, a composition for personal hygiene is provided according to which surfactants comprise a betaine surfactant. Petition 870250084774, dated 09 / 19 / 2025, page 21 / 82 5 / 51

[0021] According to embodiment 14, a personal hygiene composition is provided according to embodiment 13, wherein the betaine surfactant comprises cocamidopropyl betaine.

[0022] According to the personal hygiene code for color protection, it also comprises from about 0.01 to about 10% by weight of one or more vitamin C products.

[0023] According to embodiment 16, a personal hygiene composition is provided in accordance with vitamins C and C, which are selected from ascorbyl phosphate, ascorbyl glycoside and

[0024] According to modality 17, a composition for personal hygiene is provided in accordance with the protection of the color and weight of u

[0025] According to modality 18, a personal hygiene composition is provided in accordance with co vita

[0026] According to embodiment 19, a personal hygiene composition is provided in which one or more B vitamins comprise niacinamide.

[0027] According to modality 20, a personal hygiene composition is provided in accordance with co and

[0028] According to embodiment 21, a composition for personal hygiene is provided according to color and is evaluated by an assessment of malondialdehyde in relation to a placebo, wherein the placebo is free of vitamin B, vitamin C and vitamin E. Petition 870250084774, dated 09 / 19 / 2025, page 22 / 82 6 / 51

[0029] According to embodiment 22, a personal hygiene composition is provided according to any previous embodiment, in which the amount of light with a wavelength of 428 nm adsorbed by UVA+UVB irradiation and after UVA+UVB irradiation, in a 428 nm wavelength adsorbed by a sample Cl 19140 containing a placebo personal hygiene composition before UVA+UVB irradiation and after irradiation, contains active ingredients (e.g., free of vitamin B, vitamin C and vitamin E).

[0030] According to modality 23, a personal hygiene composition is provided according to the rinsing.

[0031] According to modality 24, a personal hygiene composition is provided according to the rinsing. BRIEF DESCRIPTION OF THE DRAWING

[0032] FIG. 1 is a bar graph that describes the reduction in pig degradation. Petition 870250084774, dated 09 / 19 / 2025, page 23 / 82 7 / 51 DETAILED DESCRIPTION

[0033] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, those skilled in the art will readily recognize that the same principles are equally applicable and may be employed in other embodiments of the present invention and disclosed herein. The terminology used in this document is for descriptive purposes and not for the purpose of application.

[0034] As used in this document and the accompanying claims, the singular forms “a / an” and “the” include plural references, unless the context clearly dictates otherwise. The singular form of any class of ingredients refers not only to one species, but also to “comprising,” “including,” and “having,” which may be used interchangeably. The term “include” should be interpreted as “including, but not limited to.”

[0035] As used throughout the document, ranges are used within the range. Any value within the range can be selected, specifically 1, 2, 3, 4, and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc. Petition 870250084774, dated 09 / 19 / 2025, p. 24 / 82 8 / 51

[0036] The term about when referring to a number means any number within a 10% range of the number. For example, the phrase “about 2% by weight” refers to a number between and including 1.8% and

[0037] All references cited in this document are incorporated by reference in their entirety. In the event of a conflict between any cited reference, the definition in this disclosure shall prevail.

[0038] The abbreviations and symbols used in this document, unless otherwise indicated, have their common meaning. The abbreviation “%” refers to personal hygiene. The symbol “°” refers to a degree, as a degree of the “μm” refers to hour, minute, milliliter, nanometer and micrometer, respectively spectroscopy, means Ultraviolet-Visible. The abbreviation “rpm” means revolutions per minute.

[0039] When referring to chemical structures and names, the symbols “C”, “H”, and “O” stand for carbon, hydrogen, and oxygen, respectively. The triple bond, respectively

[0040] Volatile, as used herein, means having a flash point below about 100°C. Non-volatile, as used herein, means having a

[0041] Any member of a species list that is used to exemplify or define a genus may be mutually different from, overlapping with, or any other explicitly. Petition 870250084774, dated 09 / 19 / 2025, p. 25 / 82 9 / 51 species that define or exemplify the genus is open, and it is given that there may be other species that define or exemplify the genus as well as or better than any other species listed.

[0042] The phrases “a mixture of the same”, “a combination of the same” or “a combination of two or more of the same” do not require that the F can be included). Instead, it indicates that a mixture of any two or more of A, B, C, D, E, and F can be included. In other words, it is equivalent to the phrase "one or more elements selected from the group consisting of and A, B, C, D, E, and F.” Similarly, the term “a salt thereof” also refers to “salts thereof.” Thus, when the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, or any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C ...

[0043] All components and elements presented positively in this disclosure may be excluded negatively from the claims. In other words, the personal hygiene compositions of this disclosure may be free or essentially free of all the co-incidences of the ingredient(s) or compound(s) described herein. This disclosure may include non-incidental amounts of this ingredient or co-incidences of personal hygiene. For example, a personal hygiene composition may contain... Petition 870250084774, dated 09 / 19 / 2025, p. 26 / 82 10 / 51 be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included co

[0044] Some of the various categories of components identified may co co co certain co co include u characterized as emulsifier and surfactant will serve only as e

[0045] For readability purposes, the chemical functional groups are and should be read as “an alkyl group”.

[0046] Aspects of the present invention are directed to co the appearance of the skin and / or preserving the pigment associated with a tattoo on the skin. According to one aspect of the invention, a co is provided of 5 10 that all percentages and co

[0047] According to another aspect of the invention, a co Petition 870250084774, dated 09 / 19 / 2025, p. 27 / 82 11 / 51 of 5% by weight of one or more vitamin E products, and from about 0.01 to about 10% by weight of one or more vitamin C products comprising ascorbyl phosphate, wherein all percentages by weight are based on the total weight of the composition for personal hygiene.

[0048] Personal hygiene compositions can be adapted to protect and / or preserve pigments associated with tattoos (also called tattoo pigments), such as Tartrazine CI 19140. Preferably, the personal hygiene compositions reduce the amount of degradation of tattoo pigments caused by exposure to ultraviolet (UV) light, such as UVA and UVB light irradiation, and / or by irradiation of 60 J / cm² of UVA and UVB light by at least 25%, preferably about 40% or more, preferably about 42% or more, preferably about 44% or more. preference around 46

[0049] The reduction in the amount of oxidative species supplied by co Petition 870250084774, dated 09 / 19 / 2025, p. 28 / 82 12 / 51 is a test evaluating malondialdehyde in relation to a placebo with the same formulation, but does not include active ingredients for preserving tattoo pigments (e.g., free of vitamin B, vitamin C, and vitamin E). Quantification of malondialdehyde (MDA) formed after UV irradiation or exposure to other forms of oxidative stress can be used as a measure of lipid peroxidation. This method has been used to measure oxidative stress. (See, for example, Alonso, C. (2009) An ex vivo methodology for evaluating lipid peroxidation in the stratum corneum. J. Photochem. Photobiol. B: Biology 97:71-76; Moysan, A. (1993) Ultraviolet-Induced Lipid Peroxidation and Antioxidant Defense Systems in Cultured Human Skin Fibroblasts. J. Invest. Dermatol. 100: 692-698; and Peres, PS (2011) Photoaging and chronological aging profile: Understanding skin oxidation.)Materials or technologies that decrease the amount of lipid peroxidation in this assay, and antioxidants are expected to help prevent pigment fading.

[0050] Additionally or alternatively, the reduction in the amount of degradation of personal hygiene products disclosed herein may be the amount of light with a wavelength of 428 nm adsorbed by the irradiation of a 428 nm wavelength adsorbed by a sample containing a placebo personal hygiene product before irradiation. Petition 870250084774, dated 09 / 19 / 2025, page 29 / 82 13 / 51 similar to the composition of personal hygiene products, but does not include the active ingredients (e.g., free of vitamin B, vitamin C, and vitamin E).

[0051] Suitable components, such as those listed below, may be included in or excluded from formulations for personal hygiene compositions, depending on the specific combination of other components, for example, personal hygiene products, such as liquid soap without rinsing, a no-rinse soap, a no-rinse lotion or a no-rinse cream.

[0052] Rinse-off compositions are normally adapted for use in a bath or similar setting after the application of such a personal hygiene composition. The rinse-off composition may be formulated to be rinsed off for approximately 2 minutes, approximately 1 second to approximately 1.5 minutes, approximately 1 second to approximately 1 minute, approximately 1 second to approximately 45 seconds, approximately 1 second to approximately 30 seconds, approximately 1 second to approximately 15 seconds; approximately 30 seconds to approximately 3 minutes, approximately 30 seconds to approximately 2 minutes, approximately 30 seconds to approximately 1 minute, approximately 30 seconds to approximately 45 seconds; approximately 1 minute to approximately 3 minutes, approximately 1 minute, or any interval or sub-interval thereof. In some cases, the composition may be suitable for use in a bath when applied and Petition 870250084774, dated 09 / 19 / 2025, p. 30 / 82 14 / 51

[0053] No-rinse compositions are typically adapted to remain on a keratin substrate, such as skin, for a period of time, for example, about 3 minutes or more, about 5 minutes or more, about 10 minutes or more, about 20 minutes or more, about 30 minutes or more.

[0054] Personal hygiene compositions are normally co-effective. The total amount of vitamin E present in the personal hygiene composition may be from about 0.01 to about 5% by weight, based on the total weight of the composition. Personal hygiene compositions may include one or more vitamin E components in an amount of about 0.01 to about 2% by weight, about 0.01 to about 1.7% by weight, about 0.01 to about 1.4% by weight, about 0.01 to about 1.2% to about 0.8% by weight, about 0.01 to about 0.6% by weight, about 0.01 to about 0.4% by weight, about 0.01 to about 0.1% by weight; from about 0.05 to about 3% by weight, about 0.05 to about 2% and 1.4 about 1 to about 0.6 wt%, about 0.05 to about 0.4 wt%, about 0.05 to about 0.2 about 0.1 to about 3 about 0.1 to about 1.7 wt, about 0.1 to about 1.2 wt%, about 0.1 to about 1 wt%, about 0.1 to about of 0.8 and 0.2 Petition 870250084774, dated 09 / 19 / 2025, page 31 / 82 15 / 51 of 2% by weight, about 0.3 to about 1.7% by weight, about 0.3 to about 1.4% by weight, about 0.3 to about 1.2% by weight, about 0.3 to about 1% by weight, about 0.3 to about 0.8% by weight, about 0.3 to about 0.6% by weight; from about 0.6 to about 3% by weight, about 0.6 to about 2 0.6 to about 1.4% by weight, about 0.6 to about 1.2% by weight, about 0.6 to about 1, from 1 to about 2, to about 1.4% by weight, about 1 to about 1.2% by weight; from about 1.5 to about 3% by weight, about 1.5 to about 2% by weight, about 2 to about 3 in the total weight of the personal hygiene composition.

[0055] As used herein, unless otherwise specified, and four isomers of tocotrienols. All eight isomers of vitamin E have tocopherols, including tocopherol, gamma-tocopherol, beta-tocopherol, and delta-tocopherol. The four tocotrienols include gamma-tocopherol. Any one of the four tocopherols in this document refers to any of the four tocopherols. It should be noted that vitamin E and / or its synthetic isoforms of vitamin E or combinations thereof. Any one or more Petition 870250084774, dated 09 / 19 / 2025, p. 32 / 82 16 / 51 of the vitamin E isomers can be in the "d" form, the "I" form, or combinations thereof. In some forms, vitamin E is vitamin E acetate or vitamin E succinate. In some forms, vitamin

[0056] Vitamin E may be selected from alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, tocopherol acetate, tocopherol phosphate, natural extracts enriched with vitamin E derivatives, and combinations of two or more of them. In some cases, one or more vitamin E, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, tocopherol acetate, tocopherol phosphate, or any combination thereof. Preferably, at least one vitamin E is selected from alpha-tocopherol, vitamin E acetate, and a combination thereof.

[0057] The personal hygiene composition may include two or more vitamin E compounds, any range formed from them. Preferably, at least one of the two or more vitamin E compounds is selected from alpha-tocopherol, vitamin E acetate, vitamin E succinate, delta-tocopherol, and a combination thereof. In at least one embodiment, the personal hygiene composition includes alpha-tocopherol and vitamin E acetate.

[0058] In addition to one or more vitamin E supplements, the personal hygiene composition typically includes at least one vitamin B supplement and / or at least one vitamin C supplement. In some preferred embodiments, the preferred co-supplement is vitamin E. Petition 870250084774, dated 09 / 19 / 2025, page 33 / 82 17 / 51 an amount of about 0.01 to about 7% by weight, based on the total weight of the personal hygiene composition. For example, the composition of personal hygiene products may include one or more B vitamins in an amount of approximately 0.01 to approximately 3% by weight, approximately 0.01 to approximately 2% by weight, approximately 0.01 to approximately 1.7% by weight, approximately 0.01 to approximately 1.4% by weight, approximately 0.6% by weight, approximately 0.01 to approximately 0.4% by weight, approximately 0.01 to approximately 0.2% by weight, approximately 0.01 to approximately 0.1% by weight, approximately 0.01 to approximately 0.05% by weight, approximately 0.05 to approximately 1.4% by weight, approximately 0.05 to approximately 1.2% by weight, and 0.8% by weight, approximately 0.05 to approximately 0.6% by weight, approximately 0.05 to approximately 0.4 0.05 to about 0.1 about 0.1 to about 2 about 0.1 to about 1.4 weight, about 0.1 to about 1 weight, about 0.1 to about 0.6 and 1.7 of 1.2 of 0.8 about 3 about 1.7 to about 1.2% by weight, about 0.6 to about 1% by weight; from about 1 to about 7% by weight, about 1 to about 5% by weight, about 1 to about Petition 870250084774, dated 09 / 19 / 2025, p. 34 / 82 18 / 51 approximately 3% by weight, approximately 1 to approximately 2% by weight, approximately 1 to approximately 1.7% by weight, approximately 1 to approximately 1.4% by weight, approximately 1 to approximately 1.2% by weight; approximately 1.5 to approximately 7% by weight, approximately 1.5 to approximately 5%, approximately 3%, approximately 7%, approximately 4% by weight, approximately 2% to approximately 3% by weight, approximately 3% to approximately 7%, personal hygiene composition.

[0059] One or more B vitamins from the personal care composition may be selected from among the B3 vitamins. Vitamin B3 may have a structure according to the formula below: where R is -CONH2 (i.e., niacinamide), -COOH (i.e., nicotinic acid) or -CH2OH (i.e., nicotinyl alcohol); a derivative of this and / or vitamin

[0060] Examples of vitamin B3 include those selected from nicotinic acid esters, non-vasodilating nicotinic acid esters, or unsaturated (including nicotinic acid oxide and niacinamide N-oxide, tocopherol nicotinate and inositol hexanicotinate). Examples of niacinamide derivatives include co Petition 870250084774, dated 09 / 19 / 2025, page 35 / 82 19 / 51 or nicotinyl chloride) with an amino acid and nicotinyl alcohol esters of organic carboxylic acids (e.g., C1-C1e). Specific examples of such derivatives include nicotinuric acid and nicotinylhydroxamic acid, which have the following chemical structures: nicotinuric acid: nicotinyl hydroxamic acid

[0061] Additional niacinamide derivatives include nicotinyl alcohol esters, such as nicotinyl alcohol esters of carboxylic acids, salicylic acid, acetic acid, glycolic acid, palmitic acid, and the like. Other examples of niacinamide derivatives include 2-chloronicotinamide, 6-aminonicotinamide, 6-methylnicotinamide, n-methylnicotinamide, n-diethylnicotinamide, nicotinamide, n-benzylnicotinamide, n-ethylnicotinamide, niphenazone, nicotinaldehyde, isonicotinic acid, niala, niaprazine, and co

[0062] In at least one form, the personal hygiene composition includes essential Petition 870250084774, dated 09 / 19 / 2025, page 36 / 82 20 / 51

[0063] The personal hygiene composition may include one or more vitamin C products, preferably in an effective amount. The total amount of vitamin 0.01 to about 5% by weight, based on the total weight of the personal hygiene composition. For example, the personal hygiene composition may include one or more vitamin C components in an amount of about 0.01 to about 2%, 1.4% by weight, about 0.01 to about 1.2% by weight, about 0.01 to about 1%, 1% to about 0.6% by weight, about 0.01 to about 0.4% by weight, about 0.01 to about 0.2%, and about 0.01 to about 0.05%. 1.7% by weight, about 0.05 to about 1.4% by weight, about 0.05 to about 1.2% by weight, about 0.05 to about 1% by weight, about 0.05 to about 0.8% by weight, about 0.05 to about 0.6% by weight, about 0.05 to about 0.4 about 0.05 to about 0.1 wt, about 0.1 to about 2 wt, about 0.1 to about 1.4 wt%, about 0.1 to about 1.2% ee 0.4 to about 3% by weight, about 0.3 to about 2% by weight, about 0.3 to about 1.7% by weight, about 0.3 to about 1.4% by weight, about 0.3 to about 1.2% by weight, about 0.3 to about 1% by weight, about 0.3 to about 0.8% by weight, about 0.3 to about 0.6% by weight; about 0.6 to about 3% by weight, about 0.6 to about 2% by weight, about 0.6 to about 1.7% by weight, about 0.6 to about 1.4% by weight, Petition 870250084774, dated 09 / 19 / 2025, page 37 / 82 21 / 51 approximately 0.6 to approximately 1.2% by weight, approximately 0.6 to approximately 1% by weight; approximately 1 to approximately 3% by weight, approximately 1 to approximately 2% by weight, approximately 1 to approximately 1.7% by weight, approximately 1 to approximately 1.4% by weight, approximately 1 to approximately 1.2% by weight, approximately 1.5 to approximately 2% by weight, approximately 2 to approximately 3% by weight, or any range or subrange thereof, based on the total weight of the co

[0064] As used herein, “vitamin C” may be ascorbic acid, derivatives thereof, and / or salts thereof. Ascorbic acid exists as two enantiomers commonly designated “I” (for “levo”) and “d” (for “dextro”). The “I” isomer is the most frequently encountered. Ascorbic acid derivatives of ascorbic acid may L-ascorbic acid, calcium ascorbate, calcium l-ascorbate dihydrate, magnesium ascorbate (also known as: magnesium ascorbate phosphate or sesquidimer salt of dehydro-L-(+)-ascorbic acid), sodium ascorbyl phosphate (also known as: sodium salt of ascorbic acid phosphate, sodium l-ascorbyl phosphate, trisodium salt of 2-phospho-L-ascorbic acid, trisodium salt of L-ascorbic acid 2-phosphate or sodium L-ascorbyl-2-phosphate), ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, ascorbyl disodium sulfate, 6-pal ascorbyl, ascorbyl propionate, stearate ascorbyl, pal ascorbyl, dipal ascorbic acid, ascorbyl ethyl ether, ascorbyl ethyl silanol pectinate or if Petition 870250084774, dated 09 / 19 / 2025, page 38 / 82 22 / 51 personal hygiene includes a vitamin C selected from ascorbyl glucoside, ascorbic acid-2-glucoside, ascorbyl acetate and a combination of two or more.

[0065] The personal hygiene composition may be formulated to have specifically a weight ratio of the total amount of vitamin E (e.g., any of the vitamin E compounds listed here) to vitamin B (e.g., any of the vitamin B compounds listed here) of about 2:1 to about 1:6. For example, the personal hygiene composition may have a weight ratio of about 2:1 to about 1:3, about 2:1 to about 1:2; about 1:1 to about 1:6, about 1:1 to about 1:5, about 1:1 to about 1:4, about 1:1 to about 1:3, about 1:1 to about 1:2, or any such range or subrange. In at least one embodiment, the weight ratio of the total amount of vitamin

[0066] And it can be for the total amount of vita vita For example and approximately 1:5, approximately 2:1 to approximately 1:4, approximately 2:1 to approximately 1:3, approximately 2:1 to approximately 1:2; approximately 1:1 to approximately 1:6, approximately 1:1 to approximately 1:5, approximately 1:1 to approximately 1:4, approximately 1:1 to approximately 1:3, approximately 1:1 to approximately 1:2, or any such interval or subinterval. At least µg for niacin. Petition 870250084774, dated 09 / 19 / 2025, p. 39 / 82 23 / 51

[0067] Additionally or alternatively, the personal hygiene composition may be formulated to specifically have a ratio of any of the vitamin C compounds listed herein) of about 14:1 to about 1:2. In certain embodiments, the personal hygiene composition has a weight ratio of the total amount of vitamin E to vitamin C that is about 14:1 to about 1:2, about 12:1 to about 1:2, about 10:1 to about 1:2, about 8:1 to about 1:2, about 7:1 to about 1:2, about 6:1 to about 1:2, about 5:1 to about 1:2, about 4:1 to about 1:2, about 3:1 to about 1:2, about 2:1 to about 1:2; from about 14:1 to about 1:1, about 12:1 to about 1:1, about 10:1 to about 1:1, about 8:1 to about 1:1, about 7:1 to about 1:1, about 6:1 to about 1:1, about 5:1 to about 1:1, about from 4:1 to about 1:1, from about 3:1 to about 1:2, from about 2:1 to about 1:1;from about 14:1 to about 2:1, about 12:1 to about 2:1, about 10:1 to about 2:1, about 8:1 to about 2:1, about 7:1 to about 2:1, about 6:1 to about 2:1, about 5:1 to about 2:1, about 4:1 to about 2:1, about from 3:1 to about 2:1; from about 14:1 to about 3:1, about 12:1 to about 3:1, about 10:1 to about 3:1, about 8:1 to about 3:1, about 7:1 to about 3:1, about 6:1 to about 3:1, about 5:1 to about 3:1, about 4:1 to about 3:1; from about 14:1 to about 4:1, about 12:1 to about 4:1, about 10:1 to about 4:1, about 8:1 to about 4:1, about 7:1 to about 4:1, about 6:1 to about 4:1, about 5:1 to about 4:1, or any interval or subinterval thereof.

[0068] In certain embodiments, personal hygiene compositions are formulated to have a specific proportion by weight of the total quantity of vita vita Petition 870250084774, dated 09 / 19 / 2025, page 40 / 8224 / 51 of 1:2. For example, the composition of personal hygiene products may have a weight ratio of the total amount of vitamin E to ascorbyl phosphate that is about 14:1 to about 1:2, about 12:1 to about 1:2, about 10:1 to about 1:2, about 8:1 to about 1:2, about 7:1 to about 1:2, about 6:1 to about 1:2, about 5:1 to about 1:2, about 4:1 to about 1:2, about 3:1 to about 1:2, about 2:1 to about 1:2; from about 14:1 to about 1:1, about 12:1 to about 1:1, about 10:1 to about 1:1, about 8:1 to about 1:1, about 7:1 to about 1:1, about 6:1 to about 1:1, about 5:1 to about 1:1, about 4:1 to about 1:1, about from 3:1 to about 1:2, about 2:1 to about 1:1;from about 14:1 to about 2:1, about 12:1 to about 2:1, about 10:1 to about 2:1, about 8:1 to about 2:1, about 7:1 to about 2:1, about 6:1 to about 2:1, about 5:1 to about 2:1, about 4:1 to about 2:1, about from 3:1 to about 2:1; from about 14:1 to about 3:1, about 12:1 to about 3:1, about 10:1 to about 3:1, about 8:1 to about 3:1, about 7:1 to about 3:1, about 6:1 to about 3:1, about 5:1 to about 3:1, about 4:1 to about 3:1; from about 14:1 to about 4:1, about 12:1 to about 4:1, about 10:1 to about 4:1, about 8:1 to about 4:1, about 7:1 to about 4:1, about 6:1 to about 4:1, about 5:1 to about 4:1, or any interval or subinterval thereof. In one embodiment, the ratio of ascorbyl is about 5:1.

[0069] Compositions for personal hygiene may comprise lactic acid and / or a salt thereof, for example, in an amount of about 0.5 to about 9% by weight, based on the total weight of the personal hygiene composition. For example, the personal hygiene composition may contain 0.5 to about 9% by weight, about 0.5 to about 7% by weight, about 0.5 to about 6% by weight, about 0.5 to about 5% by weight, about Petition 870250084774, dated 09 / 19 / 2025, p. 41 / 82 25 / 51 from 0.5 to about 4% by weight, about 0.5 to about 3% by weight, about 0.5 to about 2 from 0.5 to about 1 from 1 to about 7% by weight, about 1 to about 6% by weight, about 1 to about 5% by weight, about 1 to about 4% by weight, about 1 to about 3% by weight by weight, about 1 to about 2% by weight; from about 1.5 to about 9% by weight, about 1.5 to about 7% by weight, about 1.5 to about 6% by weight, about 1.5 to about 5% by weight, about 1.5 to about 4 about 2 about 7 of 5 and and weight, approximately 4 to approximately 5% by weight, or any range or subrange thereof, for personal hygiene may contain lactic acid in the form of salt, such as sodium lactate, potassium lactate and / or combinations thereof.

[0070] The composition for personal hygiene may comprise one of these. The hydrophilic component may include a monoalcohol, a polyol, a glycol, or may contain The oil or wax can be a linear or branched hydrocarbon, optionally volatile and its derivatives, petrolatum, polydecenes, isohexadecane, Petition 870250084774, dated 09 / 19 / 2025, page 42 / 82 26 / 51 Isododecane, hydrogenated polyisobutene, a mixture of n-undecane (C11) and n-tridecane (C13), and a combination of two or more of them. Examples of liquid hydrocarbons include linear and branched oils such as liquid paraffin, squalene, squalane, mineral oil, and low-viscosity synthetic hydrocarbons (e.g., polyalphaolefins and polybutene).

[0071] In some cases, the oil is a vegetable oil. For example, the oil may be soybean oil, marrow oil, grapeseed oil, Arabica sesame seed oil, coriander oil, castor oil, flaxseed oil, avocado oil, jojoba oil, two or

[0072] One or more oil(s) may include one or more volatile or non-volatile silicones. For example, a volatile silicone oil may be included in the co-octave cyclohexane and / or co-octave cyclohexane (acid) and the skin and / or co-octave cyclohexane (acid) and the

[0073] Silicone can have from 2 to 24 carbon atoms. For example, silicone can be a polydimethylsiloxane, optionally having from 2 to 24 carbon atoms. And optionally phenyltridiphenylpolyexe Petition 870250084774, dated 09 / 19 / 2025, page 43 / 82 27 / 51 mixture of these. Non-limiting examples of amino silicone oils include amodimethicone, aminoethylaminopropyl dimethicone, aminopropyl dimethicone and a mixture thereof.

[0074] The total amount of hydrophobic component and / or oil present in the personal hygiene composition may be, for example, from about 1 to about 35% by weight, based on the total weight of the personal hygiene composition.For example, the composition of personal hygiene products may include approximately 20% by weight, approximately 1 to approximately 10% by weight, approximately 1 to approximately 8% by weight, approximately 1 to approximately 6% by weight, approximately 1 to approximately 4% by weight, approximately 1 to approximately 3% by weight; approximately 3 to approximately 20%, approximately 8%, approximately 30%, approximately 21%, approximately 14% to approximately 35% by weight, approximately 10% to approximately 30% by weight, approximately 10% to approximately 25%, approximately 17% by weight, approximately 10% to approximately 14% by weight; approximately to approximately 35% by weight, approximately 15% to approximately 30% by weight, approximately to approximately 25% by weight, approximately 15% to approximately 21% by weight, approximately to approximately 19% by weight; from about 18 to about 35% by weight, from about 18 to about 30 from about 18 to about 21 from about 21 to about 30 from about 24 to about 35% by weight; from about 27 to about 35% by weight, about 27 to about 30% and co. Petition 870250084774, dated 09 / 19 / 2025, page 44 / 82 28 / 51

[0075] The personal hygiene composition may comprise one or more surfactants. The surfactant(s) may be any anionic, non-ionic, amphoteric, zwitterionic surfactant or combinations of two or more thereof. The amount of surfactant(s) in the composition may be from about 5 to about 45% by weight, based on the total weight of the personal hygiene composition. For example, the amount of surfactant(s) present in the composition may be from about 5 to about 35% by weight, from about 5 to about 25% by weight, from about 5 to about 20% by weight, from about 5 to about 15% by weight, from about 5 to about 13% by weight. and 45 of 25 of 15 about 35 about 20 about 13 to about 35 from 30 to about 35 from 30 to about 20 about 35 to about 40 between them, with

[0076] In one embodiment, several surfactants are used to achieve the desired product qualities. For example, a surfactant Petition 870250084774, dated 09 / 19 / 2025, p. 45 / 82 Primary surfactants (29 / 51) can be used to provide good foaming ability and cleaning efficacy, while a secondary surfactant adds softness qualities to prevent skin irritation or dryness. A variety of anionic surfactants can be used in long-chain (C6-C22) materials such as long-chain alkyl sulfates, long-chain alkyl sulfonates, long-chain alkyl phosphates, long-chain alkyl ether sulfates, long-chain alkyl alpha olefin sulfonates, long-chain alkyl taurates, long-chain alkyl isethionates (SCI), long-chain alkyl glyceryl ether sulfonates (AGES), sulfosuccinates and the like. These anionic surfactants can be alkoxylated, for example, ethoxylated, and the anionic component can be a C12-14 ethoxylated alcohol sulfate.

[0077] Anionic surfactants may be associated with a cation ion selected from sodium, potassium, alkyl and ammonium, an alkanol or anionic equivalents.

[0078] The personal hygiene composition may include one or more anionic surfactants in any of the amounts or ranges disclosed above, or amounts from about 2 to about 15 13% by weight, approximately 2 to approximately 11% by weight, approximately 2 to approximately 9 and and weight, about 4 to about 7% by weight; about 6 to about 15% by weight, about 6 to about 13% by weight, about 6 to about 11% by weight, about 6 to about 9% by weight; about 8 to about 15% by weight Petition 870250084774, dated 09 / 19 / 2025, p. 46 / 82 30 / 51 weight, approximately 8 to approximately 13% by weight, approximately 8 to approximately 11% by weight; approximately 10 to approximately 15% by weight, approximately 10 to approximately 13% and personal hygiene.

[0079] Amphoteric surfactants may also be included in the category of aliphatic secondary and tertiary amine derivatives in which the aliphatic radical may be linear or branched chain and where one of the aliphatic substituents contains a water-solubilizing anionic group, e.g., carboxyl, sulfonate, sulfate, phosphate or phosphonate. Examples of such compounds include sodium 3dodeciate, N-alkyl taurines and higher N-alkyl aspartic acids. Other equivalent amphoteric surfactants may be used.

[0080] Additional examples of amphoteric surfactants include, but are not limited to, a variety of betaines, including, for example, high-alkyl betaines such as coco dimethyl carboxymethyl betaine, lauryl dicarboxy(2-hydroxypropyl)carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine and lauryl bis-(2-hydroxypropyl)alpha-carboxyethyl betaine, sulfobetaines such as coco di betaines, a Betaines that possess a long-chain alkyl group, particularly coco, can be called coca betaines.

[0081] The personal hygiene composition may include one or more amphoteric surfactants in any of the amounts or ranges disclosed above. Petition 870250084774, dated 09 / 19 / 2025, p. 47 / 82 In 31 / 51 cases, one or more amphoteric surfactants may be present in concentrations of approximately 13% by weight, approximately 2 to approximately 11% by weight, approximately 2 to approximately 9% by weight, approximately 2 to approximately 7% by weight, and approximately 2 to approximately 5% by weight. weight, approximately 4 to approximately 7% by weight; approximately 6 to approximately 15% by weight, approximately 6 to approximately 13% by weight, approximately 6 to approximately 11% by weight, approximately 6 to approximately 9% by weight, approximately 8 to approximately 13% by weight, approximately 8 to approximately 11% by weight; approximately 10 to approximately 15% by weight, approximately 10 to approximately 13% by weight and personal hygiene.

[0082] The composition for personal hygiene may include one or more surfactants selected from nonionic surfactants. Examples of nonionic surfactants include polysorbate 20, long-chain alkyl glycosides having C8-C22 alkyl groups; coconut fatty acid monoethanolamides, such as fatty alcohol (alkylpolyethylene glycols); alkylphenol polyethylene glycols; alkyl polyethylene glycols (alkyl (acylpolyethylene glycols); polypropylene glycol ethoxylates (e.g., the commercially available PLURONIC™ block copolymers from BASF); alkyl esters of sorbitol; polyglycol ethers; and combinations thereof.

[0083] Non-ionic surfactant(s) may be present in u co Petition 870250084774, dated 09 / 19 / 2025, p. 48 / 82 32 / 51 One or more non-ionic surfactant(s) is / are present in the personal hygiene composition in an amount of about 0.1 to about 6% by weight, about 0.1 to about 5% by weight, about 0.1 to about 4% by weight, about 0.1 to about 3% by weight, about 0.1 to about 1% by weight; about 0.4 to about 7% by weight, about 0.4 to about 6% by weight, about 0.4 to about 5% by weight, about 0.4 to about 4% by weight, about 0.4 to about 2% by weight; about 0.8 to about 7% by weight, about 0.8 to about 6% by weight; from approximately 3 to approximately 7 pounds, approximately 3 to approximately 5 pounds, approximately 4 to approximately 6 pounds, or any range or subrange thereof, based on the total weight of the personal hygiene composition.

[0084] Cationic surfactants may also be included in the co-op at any desired level. The cationic surfactant(s) may be present in an amount of about 0.1 to about 5 ex e.g. Petition 870250084774, dated 09 / 19 / 2025, page 49 / 82 33 / 51 weight, about 0.1 to about 3% by weight, about 0.1 to about 2% by weight, about 0.1 to about 1% by weight; from about 0.3 to about 5% by weight, about 0.3 to about 4% by weight, about 0.3 to about 3% by weight, about 0.3 to about 2% by weight, about 0.3 to about 1% by weight; from about 0.6 to about 5% by weight, about 0.6 to about 4% by weight, about 0.6 to about 3% by weight; from about 1.5 to about 5% by weight, about 1.5 to about 4% by weight, about 1.5 to about 3% by weight; from about 2 to about 5% by weight, about 2 to about 4, about 3 to about 5, or 4 to about 5 of these, based on the total weight of the personal hygiene composition.

[0085] Personal hygiene compositions, in certain embodiments, may contain monomers substituted with amine and / or quaternary ammonium compounds and / or compatible spacer monomers. Suitable cationic polymers include, for example: copolymers of 1-vinyl-2-pyrrolidine and 1-vinyl-3-methylimidazolium salt (e.g., chloride salt) (referred to as Polyquaternium-16), co LUVIQUAT (e.g., LUVIQUAT FC 370); copolymers of 1-vinyl-2-pyrrolidine and co USA) under the trade name GAFQUAT (e.g., GAFQUAT 755N); and cationic polymer containing diallyl quaternary ammonium, including, for example... Petition 870250084774, dated 09 / 19 / 2025, pp. 50 / 82 34 / 51 acrylamide and dimethyldiallyl ammonium chloride (referred to as Polyquaternium-6 and Polyquaternium-7), and combinations thereof.

[0086] Other cationic polymers that can be used include polysaccharide polymers, such as cationic cellulose derivatives and cationic starch derivatives. Cationic cellulose is available from Amerchol Corp. (Edison, NJ, USA) in its Polymer JR (trademark) and LR (trademark) series of polymers, as hydroxyethyl cellulose salts react with epoxide substituted by trimethyl ammonium (referred to as Polyquaternium-10). Another type of cationic cellulose includes polymeric salts of lauryl dimethyl ammonium substituted (referred to as Polyquaternium-24). These materials are available from Amerchol Corp. (Edison, NJ, USA) under the name polyhydroxypropyltrimonium guar chloride.

[0087] The personal hygiene composition may include or be selected from polyquaterniums. In one case, one or more cationic polymers are selected from polyquaternium-4, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium 22, polyquaternium 28, polyquaternium 32, polyquaternium-46, polyquaternium-51, polyquaternium-52, polyquaternium-53, polyquaternium-54, polyquaternium-55, polyquaternium-56, polyquaternium-57, polyquaternium-58, polyquaternium-59, polyquaternium-60, polyquaternium-63, polyquaternium-64, polyquaternium-65, polyquaternium-66, polyquaternium-67, polyquaternium-70, polyquaternium-73, polyquaternium-74, polyquaternium-75, polyquaternium-76, polyquaternium-77, polyquaternium-78, polyquaternium-79, polyquaternium-80, polyquaternium-81, polyquaternium-82, polyquaternium-84, polyquaternium-85, polyquaternium-86, polyquaternium-87, polyquaternium-90, polyquaternium-91, polyquaternium-92, polyquaternium-94, guar hydroxypropyltrimonium chloride and Petition 870250084774, dated 09 / 19 / 2025, pp. 51 / 82 35 / 51 a combination of two or more of the same. In at least one embodiment, the cationic polymer comprises an acrylamide and diallyldimethylammonium chloride copolymer.

[0088] The cationic polymer(s) may be present in u co poli from 0.1 to about 6% by weight, from 0.1 to about 5% by weight, from 0.1 to about 4% by weight, from 0.1 to about 3% by weight, from 0.1 to about 2% by weight, from 0.1 to about 1% by weight; from about 0.4 to about 7% by weight, from 0.4 to about 6% by weight, from 0.4 to about 5% by weight, from 0.4 to about 3% by weight, from 0.4 to about 2% by weight, from 0.4 to about 1% by weight; from about 0.8 to about 7% by weight, from about 0.8 to about 6% by weight, from about 0.8 to about 5% by weight, from about 0.8 to about 4% by weight, from about 0.8 to about 2% by weight; from about 1.4 to about 7% eeee weight, approximately 2 to approximately 3 weight, approximately 3 to approximately 6 from approximately 4 to approximately 7 approximately 5 to approximately 7 based on the total weight of the personal hygiene composition

[0089] The personal hygiene composition may include one or more pH adjusters to increase or decrease the overall pH of the personal hygiene composition. For example, one or more acids may be included to Petition 870250084774, dated 09 / 19 / 2025, pp. 52 / 82 36 / 51 Lowering the pH of the personal hygiene composition. Examples of acids suitable for lowering the pH of the personal hygiene composition include, but are not limited to, citric acid, acetic acid, and the like. The personal hygiene composition may include one or more bases, such as sodium hydroxide, potassium hydroxide, and the like, to raise the pH of the personal hygiene composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the personal hygiene composition are readily known to one skilled in the art.

[0090] The amount of pH adjuster in the personal care composition may be based on the desired pH of the composition and / or final personal care product. For example, the total amount of pH adjuster may vary from about 0.05 to about 20% by weight, based on the total weight of the composition. The total amount of pH adjuster is about 0.05 to about 15% by weight, about 0.1 to about 10% by weight, or about 0.12 to about 5% by weight, including ranges and subranges in between, based on the total weight of the composition.

[0091] Personal hygiene compositions may have a pH of 4.5 to about 10, 4.5 to about 9, 4.5 to about 8, 4.5 to about 7, 4.5 to about 6; from about 5 to about 10, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6; from about 6 to about 10, about 6 to about 9, about 6 to about 8, or about 6 to about 7; from about 7 to about 10, about 7 to about 9, or about 7 to about 8, including any ranges and subranges in between. In some embodiments, the personal hygiene composition has a pH of about 3.5 to about 7.5. In other forms, the composition for personal hygiene products has a pH of approximately 4.5. Petition 870250084774, dated 09 / 19 / 2025, pp. 53 / 82 37 / 51 at approximately 6.5. Other types also provide personal hygiene compositions with a pH of approximately 5 to approximately 6.5.

[0092] Additional ingredients may be present in the personal hygiene composition. This includes water and ingredients for thickening, preserving, and personal hygiene may be present in an amount of about 0.01 to about 5% by weight, based on the total weight of the product. Additional ingredients present in the product may be about 0.01 to about 4% by weight, about 0.01 to about 3% by weight, about 0.01 to about 2% by weight, about 0.01 to about 1% by weight, about 0.01 to about 0.5% by weight, about 0.01 to about 0.1% by weight; about 0.1 to about 5% by weight, about 0.1 to about 4% by weight, about 0.1 to about 3% by weight, about 0.1 to about 1% by weight, about 0.1 to about 0.5% by weight, about 0.1 to about 0.1% by weight; about 0.5 to about 5% by weight, about 0.5 to about 4% by weight, about 0.5 to about 2% by weight; about 0.75 to about 5% by weight, about 0.75 to about 4% ee weight, approximately 2 to approximately 4, approximately 3 to approximately 5, including any interval or subinterval between them, based on the total weight of the co

[0093] The composition of personal hygiene products may include additional ingredients, such as proteins (e.g., vegetable protein). Petition 870250084774, dated 09 / 19 / 2025, pp. 54 / 82 38 / 51 hydrolyzed, hydrolyzed wheat protein, hydrolyzed milk protein, hydrolyzed silk and hydrolyzed collagen), vitamins (e.g., panthenol, biotin, vitamin A and palmitate D), moisturizers / humectants (e.g., glycerin, propylene glycol, sodium pyroglutamic acid (also known as, for example, esters, isopropyl myristate, decyl oleate, C12-15 alkyl benzoate), botanicals (e.g., chamomile, aloe vera, rosemary), as well as including milk protein and / or hydrolyzed milk protein in an amount or range described above with respect to additional ingredients. Additional examples of personal hygiene products include

[0094] Non-limiting examples of fragrances and perfumes include co 1,1,6,7-tetramethylnaphthalene, α-ionone, β-ionone, γ-ionone, α-isomethylionone, methylcedrilone, methyl dihydrojasmonate, methyl 1,6,10-trimethyl-2,5,9-cyclododecatrien-1-yl ketone, 7-acetyl-1,1,3,4,4,6-hexamethyltetraline, 4-acetyl-6-tert-butyl-1,1-di naphthyl ketone, 6-acetyl-1,1,2,3,3,5-hexamethylindane, 5-acetyl-3-isopropyl-1,1,2,6-tetracyclohexene-1-carboxaldehyde, 7-hydroxy-3,7-diisohexenylcyclohexylcarboxaldehyde, condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxycitronellal and indole, condensation products of phenylacetaldehyde and indole, 2-ethylvanillin, heliotropin, hexylcine (isopropylphenyl)propionaldehyde, cyclopentadecanolide, 16-hydroxy-9-hexadecenoic acid lactone, Petition 870250084774, dated 09 / 19 / 2025, pp. 55 / 82 39 / 51 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-Y-2-benzopyran, β-naphthol methyl ether, ambroxane, dodecahydro-3a,6,6,9atetramethylnaphtho[2,1b]furan, cedrol, 5-(2,2,3-trimethylcyclopent-3-enyl)-3methylpentan-2-ol,2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate and tert-butylcyclohexyl.

[0095] Other fragrances may include odor compounds selected from essential oils, resinoids and resins from a large number of sources, such as, for example, Peru balsam, frankincense resinoid, styrax, labdanum resin, nutmeg, cassia oil, benzoin resin, coriander and lavandin.

[0096] Other suitable fragrances include selected odor compounds of phenylethyl alcohol, terpineol, linalool, linalyl acetate, geraniol, nerol, 2-(1,1-dimethylethyl)cyclohexanol acetate, benzyl acetate, and eugenol. Fragrances or perfumes may be used as single substances or and

[0097] The personal hygiene composition may further comprise one or mixtures. Non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, and colorants (dyes) are known as FD&C dyes.

[0098] The colorants may be present in an amount ranging from about 0.0001% by weight to about 0.4% by weight, including all percentages and subranges in between, co co may Petition 870250084774, dated 09 / 19 / 2025, pp. 56 / 82 40 / 51 approximately 4% by weight, including all percentages and sub-ranges in between, based on the total weight of the personal hygiene composition.

[0099] In certain embodiments, in order to prevent the ingredients from separating, emulsifiers may be added. In certain embodiments, additional ingredients may include conditioning agents that moisturize the skin during and after use of the personal hygiene composition.

[00100] In other embodiments, the personal hygiene composition may include any of the following materials in any quantity desired to achieve a desired effect in the composition (quantities that may be: alkaline salts, for example, sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate and / or their equivalents (0 to 5% by weight); sequestrants, for example, tetrasodium EDTA and / or its equivalents (0 to 2% by weight); biocides, for example, triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), DMDM ​​hydantoin, formaldehyde and / or imidazolidinyl urea and / or their equivalents (0 to 2%); citric acid and / or formic acid and / or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and / or perfumes (0 to 5%); pearlescent agents, for example, glycol distearates, such as ethylene glycol distearate, fatty acids (0 to 3% by weight); stabilizers, for example, metallic salts of fatty acids, approved and suitable for cosmetic purposes.

[00101] Personal hygiene compositions can be aqueous and, for example, Petition 870250084774, dated 09 / 19 / 2025, pp. 57 / 82 41 / 51 For example, water may be present in the composition of personal hygiene products in an amount of about 30 to about 96% by weight, about 40 to about 96% by weight, about 50 to about 96% by weight, about 60 to about 96% by weight, about 96 to about 90% by weight, about 40 to about 90% by weight, about 50 to about 90% by weight, about 80 to about 90% by weight, about 85 to about 90% by weight; from about 25 to about 85 wt%, from about 40 to about 85 from 60 to about 85 from about 25 to about 80 from about 50 to about 80 from about 70 to about 80 wt, from about 40 to about 70 wt%, from about 50 to about 70 wt%, from about 60 to about 70 ee of co.

[00102] In some forms, the amount of water in the co weight, co exe quantity of about 1 to about 20% by weight, about 1 to about 10 and weight; from about 3 to about 20% by weight, from about 3 to about 10% by Petition 870250084774, dated 09 / 19 / 2025, pp. 58 / 82 42 / 51 weight, about 3 to about 8% by weight, about 3 to about 6% by weight; from about 5 to about 30% by weight, about 5 to about 25% by weight, about 5 to about 21 about 5 to about 14 about 10 to about 35 about 10 to about 25 about 10 to about 17% by weight, about 10 to about 14% by weight; from about 15 to about 35 wt., from about 15 to about 25 wt., from about 15 to about 19% by weight; from about 18 to about 35% ee approximately 30, the total weight of the personal hygiene composition.

[00103] The composition for personal hygiene may, in some cases, contain tallow and / or soap flakes. The amount of tallow and / or soap flakes in the composition is 85 For example, the composition of personal care products may include a total amount of tallow and / or soap of 80 70 Petition 870250084774, dated 09 / 19 / 2025, pp. 59 / 82 43 / 51 60% by weight; from about 55 to about 85% by weight, from about 55 to about 80% by weight, from about 55 to about 75% by weight, from about 55 to about 70% by weight, from about 55 to about 65% by weight; from about 60 to about 85% by weight, from about 60 to about 80% by weight, from about 60 to about 75%, from 65 to about 85%, from 65 to about 75%, from 70 to about 85%, from 75 to about 85%, based on the total weight of the personal hygiene composition. Soap flakes may be coconut soap flakes or similar.

[00104] Personal hygiene compositions may also include caustic soda, for example, in an amount of about 1 to about 25% by weight, based on the total weight of the personal hygiene composition. In some embodiments, the amount of soap flakes in the personal hygiene composition is about 1 to about 20% by weight, about 1 to about 10, about 6, 3, 10, 6, 21, 14, 25, 17, about 25, about 19% by weight; about 18 to about 25% by weight, about 18 to about 21% by weight; about 21 to about 25% by weight, or Petition 870250084774, dated 09 / 19 / 2025, pp. 60 / 82 44 / 51 any range or subrange thereof, based on the total weight of the personal hygiene composition.

[00105] The personal hygiene composition may, in some cases, include u present in an amount of about 1 to about 15% by weight, based on the total weight of the co u about 1 to about 14 about 1 to about 11 about 1 to about 7% by weight, about 1 to about 5% by weight, about 1 to about 3% by weight; from about 2 to about 15% by weight, about 2 to about 13% by weight, about 2 to about 11% by weight, about 2 to about 9% by weight, about 2 to about 7% by weight, about 2 to about 5 about 13 about 9 about 15 about 11 about 15 about 11 to about 13% by weight, or any range or subrange thereof, based on the co

[00106] In some cases, fatty acids may be chosen from fatty acid derivatives, fatty acid esters, hydroxyl-substituted fatty acids, and alkoxylated fatty acids. Fatty acids may be either saturated or unsaturated. Examples include triacids and other exe acids. Petition 870250084774, dated 09 / 19 / 2025, pp. 61 / 82 45 / 51 lauric acid, palmitic acid, stearic acid, behenic acid, arikidonic acid, oleic acid, isostearic acid, sebacic acid and a mixture thereof. In some cases, the fatty acids are selected from the group consisting of palmitic acid, stearic acid and a mixture thereof.

[00107] Non-limiting examples of polyglycerol esters of fatty acids include those of the following formula: OR2 R1-(OCH2-CH-CH2O)n-R3e to be independent by R1, R2, and R3 can be saturated or unsaturated, linear or branched, and have co C10.

[00108] Fatty acid derivatives are defined herein to include fatty acid esters of fatty alcohols as defined above, fatty acid esters of fatty alcohol derivatives when such fatty alcohol derivatives have an esterifiable hydroxyl group, fatty acid esters of alcohols other than fatty alcohols, and the fatty alcohol derivatives described above, and a mixture thereof. Non-limiting examples of fatty acid derivatives include hydroxy stearic acid, ethyl stearate, cetyl stearate, polyoxyethylene cetyl ether stearate, polyoxyethylene stearyl ether stearate, polyoxyethylene lauryl ether stearate, ethylene glycol, propylene glycol monostearate, propylene glycol distearate, and diethyl glycol trisebacate distearate. Petition 870250084774, dated 09 / 19 / 2025, pages 62 / 82 46 / 51 Glyceryl monostearate, glyceryl distearate, glyceryl tristearate, PEG-8 laurate, PPG-2 isostearate, PPG-9 laurate, and a mixture thereof. Preferred for use herein are glyceryl monostearate, 12-hydroxystearic acid, and a mixture thereof.

[00109] Aspects of the invention are directed to methods for preserving the pigment associated with a tattoo on the skin, improving skin health and / or co the four) personal hygiene compositions. The methods may employ the co

[00110] The methods typically involve applying an effective amount of the personal hygiene composition to a patch of skin. The amount of personal hygiene composition applied to the skin can range from about 0.1 to about 5 grams per square inch of skin. In some cases, the amount of co 0.1 to about 3 grams / inch², about 0.1 to about 2 grams / inch², about 0.1 to about 1 gram / inch²; about 0.5 to about 3 grams / inch², about 0.5 to about 2 grams / inch², about 0.5 to about 1 gram / inch²; about 1 to about 3 grams / inch², about 1 to 2 grams / inch²; about 1.5 to about 3 grams / inch², about 1.5 to about 2 grams / inch², including any intervals or subintervals between them. The personal composition can be spread on the skin as instructed.

[00111] A sufficient period of time to cleanse the skin area — for example, from about 1 second to about 3 minutes, from about 1 to about 45 seconds, from about 1 to about 30 Petition 870250084774, dated 09 / 19 / 2025, pp. 63 / 82 47 / 51 seconds or about 1 to about 15 seconds. As is common, the skin can be wetted or rinsed with water before applying the personal hygiene product; this can be beneficial to enhance the effects of certain products.

[00112] The method may, in some cases, include a drying step on the skin area. The skin can be dried with a towel, hair dryer or other means, for example, depending on the degree of dryness desired before applying the lotion composition. EXAMPLES Example 1

[00113] Six compositions for personal hygiene (AF Compositions) apart from the formulas shown in Table 1. Table 1 Ingredient Name Comp. A (% by weight) Comp. B (% by weight) Comp. C (% by weight) Comp. D (% by weight) Comp. E (% by weight) Comp. F (% by weight) C12-14 Alcohol EO 2:1 Sodium Sulfate 8.3 8.3 8.3 8.3 8.3 8.3 Cocamidopropyl Betaine 8.5 8.5 8.5 8.5 8.5 8.5 Lactic Acid 1.8 1.8 1.8 1.8 1.8 1.8 Polyquaternium-7 0.6 0.6 0.6 0.6 0.6 0.6 Cocomonoethanolamide 0.5 0.5 0.5 0.5 0.5 0.5 Caustic Soda Na2O 0.2 0.2 0.2 0.2 0.2 0.2 Pearly Base 0.5 0.5 0.5 0.5 0.5 0.5 EQUILIBRIUM 2020 1.1 1.1 1.1 1.1 1.1 1.1 ALKESTE 150 DVG (PEG 6000) 0.25 0.25 0.25 0.25 0.25 0.25 EDTA 0.22 0.22 0.22 0.22 0.22 0.22 Linseed Oil 0.2 0.2 0.2 0.2 0.2 0.2 PEG-18 Castor Oil Dioleate 0.2 0.2 0.2 0.2 0.2 0.2 Sodium Benzoate 0.15 0.15 0.15 0.15 0.15 0.15 Glycerin 0.00010.1 0.00010.1 0.00010.1 0.00010.1 0.00010.1 0.00010.1 Petition 870250084774, dated 09 / 19 / 2025, pp. 64 / 82 48 / 51 Vitamin E, N, F (ALPHA) 0.01 0.01 0.1 0.1 0.1 Bisabolol 0.25 0.125 Niacinamide USP 0.2 Tocopherol acetate 0.1 0.1 0.1 Sodium ascorbyl phosphate 0.02 0.01 Water QS to 100 QS to 100 QS to 100 QS to 100 QS to 100 QS to 100 Example 2

[00114] Composition A of Example 1 was evaluated to determine if niacinamide would be rinsed off during use. A sample of Composition A was applied to 2-inch by 2-inch pieces of pig skin (provided by Animal Technologies) with the subcutaneous fat removed. For the rinsing procedure, the skin from the pig's back was rinsed off. Specifically, the pig's back skin was first moistened for five seconds. Then, 50 µL of Composition A was applied to the pig's back skin and rubbed in for 10 seconds. The pig's back skin was then left to rest for 90 seconds and then rinsed with water for 15 seconds. After allowing the skin to air dry for 5 minutes, a glass cup (3 cm in diameter) was applied to the skin surface. 3 mL of ethanol was poured out of the glass and then extracted into a labeled scintillation vial. This was repeated outside and HPLC vial. The samples were then run on the HPLC for niacinamide quantification.

[00115] An HPLC, namely an Agilent 1100 series HPLC with a UV-Vis detector, was used for the quantification of niacinamide. A millimeter (µm) was used. The mobile phase consisted of 90 / 10 acetonitrile / water, which was run at Petition 870250084774, dated 09 / 19 / 2025, pages 65 / 82 49 / 51 a flow rate of 1 ml / min. 20 uL of solution were injected. Niacinamide can be detected at 260 nm with a retention time of approximately 2.2 minutes.

[00116] The high water solubility of niacinamide suggests that most of it will be removed by water during the rinsing process. Therefore, to maximize the possibility of detecting niacinamide, the minimum amount of mobile phase solvent should be used to increase the concentration of niacinamide present.

[00117] HPLC analysis revealed a significant peak in the retention time of unexpectedly deposited niacin, calculated at 0.065 + / - 0.030 ug / cm2. Example 3

[00118] The AF compositions were evaluated to verify if the respective co-options were effective against tattoos. Specifically, each of the AF compositions was evaluated using antioxidants from the respective co-options for product application, and served co-ops were rinsed, dried, and exposed to oxidative stress. Lipids are then extracted using the cup cleaning method, and the amount of lipid peroxidation is evaluated using a malondialdehyde (MDA) lipid peroxidation kit (Millipore-Sigma).

[00119] A summary of the results is shown in FIG. 1. In FIG. 1, u Exe Petition 870250084774, dated 09 / 19 / 2025, pp. 66 / 82 50 / 51

[00120] Two compositions for personal hygiene (Compositions G and H) were prepared in the form of a liquid body soap bar, according to the formulas shown in Table 2. Table 2 Comp. G (% by weight) Comp. H (% by weight) Crude tallow 65.6 Sodium soap 70.5 Caustic soda Na2O 7.7 Sodium dodecylbenzene sulfonate 1.9 1.9 Lauric acid and / or free fatty acid 5.2 1.5 Fatty acid ester 0.05-0.1 Cocomonoethanolamide 1.9 Cocamidopropyl betaine 1.6 0.5 Cocamide MEA 1.9 Citric acid or sodium citrate 0.5 0.7 Hydrolyzed milk protein 1 0.2 Miscellaneous (fragrance, pigment, titanium dioxide, iron oxide and / or sodium benzoate) approximately 2 approximately 1 Sodium chloride 0.6 0.9 Virgin linseed oil 0.5 Niacinamide 0.2 0.2 d-Gamma Tocopherol 0.03 0.03g Tetrasodium EDTA - 0.05g - 0.1g 0.01g - 0.05g Etidronic Acid 0.01g - 0.1g 0.01g - 0.1g Glycerin 6.9g Linum Usitatissimum (Flaxseed) Seed Oil 0.5g Sodium Carbonate 0.01g - 0.1g Ethanolamine 0.01g - 0.1g Water QS to 100g QS to 100g Example 5

[00121] Composition G of Example 4 was evaluated to verify whether the niacinamide would be rinsed away during use. Compositions G were evaluated according to the procedure described in Example 2. As observed above, most of it will be removed by water during the rinsing process. HPLC analysis, however, revealed a significant peak in the retention time of niacinamide, indicating that the niacinamide remained Petition 870250084774, dated 09 / 19 / 2025, pp. 67 / 82 51 / 51 unexpectedly after rinsing. Specifically, the level of niacinamide deposited was calculated at 0.0086 + / - 0.039 ug / cm2. Petition 870250084774, dated 09 / 19 / 2025, pp. 68 / 82

Claims

1 / 3 CLAIMS 1. A composition for personal hygiene, characterized in that it comprises: a cosmetically acceptable carrier; and a color protection component comprising: from about 0.01 to about 5% by weight of one or more vitamin E, and from about 0.01 to about 7% by weight of one or more vitamin B comprising niacinamide, wherein all percentages by weight are based on the total weight of the composition for personal hygiene.

2. A composition for personal hygiene, characterized in that it comprises: a cosmetically acceptable carrier; and a color protection component comprising: from about 0.01 to about 5% by weight of one or more vitamin E, and from about 0.01 to about 5% by weight of one or more vitamin C comprising ascorbyl phosphate, wherein all percentages by weight are based on the total weight of the composition for personal hygiene.

3. A composition for personal hygiene, according to claim 1 or 2, characterized in that one or more vitamin E components comprise vitamin E acetate, vitamin E succinate, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, tocopherol acetate, tocopherol phosphate, or any combination thereof.

4. Personal hygiene composition, according to any of the preceding claims, characterized in that one or more vitamin E products comprise alpha-tocopherol and vitamin E acetate. Petition 870250084774, dated 19 / 09 / 2025, pp. 76 / 82 2 / 3 5. Personal hygiene composition, according to claim 1, characterized in that the personal hygiene composition has a weight ratio of the total amount of vitamin E to niacinamide of about 2:1 to about 1:

6.

6. Personal hygiene composition, according to claim 2, characterized in that the personal hygiene composition has a weight ratio of the total amount of vitamin E to ascorbyl phosphate of about 14:1 to about 1:

2.

7. Composition for personal hygiene, according to claim 1, characterized in that the color protection component further comprises from about 0.01 to about 10% by weight of one or more vitamin C products, wherein the one or more vitamin C products are selected from ascorbyl phosphate, ascorbyl glycoside and a combination of two or more thereof.

8. Composition for personal hygiene, according to claim 2, characterized in that the color protection component further comprises from about 0.01 to about 10% by weight of one or more B vitamins.

9. Personal hygiene composition, according to any of the preceding claims, characterized in that the personal hygiene composition reduces the amount of color change by at least 25% by weight, as assessed by the difference between the amount of light with a wavelength of 428 nm adsorbed by sample CI 19140 containing the personal hygiene composition before and after UVA+UVB irradiation, compared with the difference between the amount of light with a wavelength of 428 nm adsorbed by a sample CI 19140 containing a placebo personal hygiene composition before and after UVA+UVB irradiation, wherein the placebo has a formulation similar to that of the personal hygiene composition but does not include the active ingredients (e.g., free of vitamin B, vitamin C, and vitamin E).

10. Personal hygiene composition, according to any of the preceding claims, characterized in that the personal hygiene composition is in the form of a rinse-off composition or a leave-in composition. Petition 870250084774, dated 19 / 09 / 2025, pp. 78 / 82

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