Use of a class of organic acid metal compounds as animal feed additives

Description

1 / 36 “USE OF A CLASS OF ORGANIC ACID METAL COMPOUNDS AS ANIMAL FEED ADDITIVES” TECHNICAL FIELD

[001] The present invention relates to the field of animal feed additives, and in particular to the use of a class of organic acid metal compounds and / or solvates thereof as animal feed additives or in the preparation of animal feed additives. BACKGROUND OF THE TECHNIQUE

[002] Organic Al compounds are of a wide variety and are widely used, and common organic Al compounds comprise Al formate compounds and Al acetate compounds. Al formate compounds are frequently used as catalysts in organic synthesis reactions, particularly in esterification reactions, which can promote the formation of esters and increase the reaction rate and yield, such as the synthesis of amino acid esters. As a wood preservative, Al formate compounds can protect wood from fungi, insects, and other organisms, and extend the lifespan of wood by penetrating the surface and binding to fibers in the wood to form a protective film. Al formate compounds can be used as an ingredient in certain dyes and pigments, and can also be added to paper pulp as a paper reinforcing agent. Al acetate compounds have antibacterial, anti-inflammatory, and antipruritic effects.At the beginning of the 20th century, aluminum acetate compounds were used as preservatives, astringents, and antipyretics in technical fields such as medicine and dyes. Aluminum acetate compounds can also be used as catalysts and color-fixing agents in leather dyeing and tanning processes.

[003] In addition, organic Al compounds are disclosed that can be used in the preparation of polyurethane foams, or as anti-caking agents, stabilizers or viscosity control agents in liquid bases, sunscreens and moisturizing creams, or as nucleating agents and surfactants for plastic processing, or as one of the ingredients of an antifoaming agent, or as one of the ingredients of a conductive paste in Petition 870250085925, dated 09 / 23 / 2025, page 10 / 157 2 / 36 preparation of an electrode for a chip resistor, or as one of the ingredients in a grease composition, or as catalyst compositions for polyesters. However, there are no reports of the use of organic acid Al compounds in the feed industry and in the field of livestock farming. SUMMARY OF THE INVENTION

[004] Based on this, the present invention provides the use of a class of organic acid metal compounds and / or solvates thereof as animal feed additives or in the preparation of animal feed additives, and further provides a composition comprising the organic acid metal compounds and / or solvates thereof.

[005] In order to achieve the aforementioned object of the present invention, the present invention provides the use of an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne and / or a solvate thereof as an animal feed additive or in the preparation of an animal feed additive: where n is any natural number; R1 is selected from YC(O)O- or a plant polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- or a plant polyphenol; Y is selected from H, linear or branched C1-C19 alkyl or linear or branched C1-C19 alkyl substituted by 1-5 R4, C3-C7 cycloalkyl or C3-C7 cycloalkyl substituted by 1-5 R4, C3-C7 cycloheteroalkyl or C3-C7 cycloheteroalkyl substituted by 1-5 R4, C5-C12 aryl or C5-C12 aryl substituted by 1-5 R5, C5-C12 heteroaryl or C5-C12 heteroaryl substituted by 1-5 R5, -(CH=CH)m-(C5-C12 aryl) or -(CH=CH)m-(C5-C12 aryl) where C5-C12 aryl is substituted by 1-5 R5, -(CH=CH)m-(C5-C12 heteroaryl) or -(CH=CH)m-(C5-C12 heteroaryl) where C5-C12 heteroaryl is replaced by 1-5 R5; m is any natural number; R4 is -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I; and R5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I. Petition 870250085925, dated 09 / 23 / 2025, p. 11 / 157 3 / 36

[006] The present invention further provides a composition comprising an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne and / or a solvate thereof; preferably, the organic acid metal compound and / or the solvate thereof is an active component.

[007] The present invention further provides for the use of an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof as an animal feed additive or in the preparation of an animal feed additive, wherein preferably the animal feed additive is an animal growth promoter.

[008] The present invention provides a method for improving the production performance of an animal, wherein the method comprises applying to the animal an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof or a composition comprising an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof.

[009] In the present invention, it is confirmed, through livestock activity experiments, that the organic acid metal compound and / or the solvate thereof provided in the present invention can effectively cause animals to gain weight and increase the feed conversion rate, and has a satisfactory effect on improving animal production performance;and most notably, the organic acid metal compound and / or the solvate thereof provided in the present invention are essentially residue-free in tissues, such as muscles and liver of edible animals, and the elemental aluminum content is below the instrumental detection limit of detection institutions for elemental aluminum or below the elemental aluminum content in commercially available meat products or below the elemental aluminum content in the meat of edible animals in a blank control group not receiving organic acid metal compounds, in accordance with the aluminum residue requirements specified in the GB 2760-2014 food additive use standard [residual amount of aluminum < 100 mg / kg (equivalent to 100 ppm), (dry sample, in terms of Al)]. Petition 870250085925, dated 09 / 23 / 2025, p. 12 / 157 4 / 36

[010] Any embodiment of any aspect of the present invention may be combined with other embodiments, unless they are contradictory to each other. Furthermore, in any embodiment of any aspect of the present invention, any technical feature may be applied to the technical feature in other embodiments, unless they are contradictory to each other.

[011] The above-mentioned content is merely a summary of certain aspects of the present invention, but without limitation to those aspects. The content involved above and in other aspects will be described more specifically and completely below. DETAILED DESCRIPTION OF THE INVENTION

[012] The following detailed description is intended to enable those skilled in the art to implement different embodiments. Specific devices, techniques, or applications are described only by way of example. The present invention is intended to cover all alternative, modified, and equivalent technical solutions, all of which are included within the scope of the present invention as defined by the claims. Additionally, for clarity, some technical features of the present invention are described in multiple independent embodiments, respectively, but may also be provided in combination or in the form of any suitable subcombination in a single embodiment. Organic acid metal compounds involved in the present invention.

[013] The present invention relates to a class of organic acid metal compounds having a molecular formula of Aln(R1)n(R2)n(R3)ne and / or solvates thereof, wherein n is any natural number; R1 is selected from YC(O)O- or a plant polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- or a plant polyphenol; Y is selected from H, linear or branched C1-C19 alkyl or linear or branched C1-C19 alkyl substituted by 1-5 R4, C3-C7 cycloalkyl or C3-C7 Petition 870250085925, dated 09 / 23 / 2025, p. 13 / 157 5 / 36 cycloalkyl substituted by 1-5 R4, C3-C7 cycloheteroalkyl or C3-C7 cycloheteroalkyl substituted by 1-5 R4, C5-C12 aryl or C5-C12 aryl substituted by 1-5 R5, C5-C12 heteroaryl or C5-C12 heteroaryl substituted by 1-5 R5, -(CH=CH)m-(C5C12 aryl) or -(CH=CH)m-(C5-C12 aryl) where C5-C12 aryl is substituted by 1-5 R5, -(CH=CH)m-(C5-C12 heteroaryl) or -(CH=CH)m-(C5-C12 heteroaryl) where C5-C12 heteroaryl is substituted by 1-5 R5; m is any natural number; R4 is -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I; and R5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I.

[014] In general, “substituted” means that one or more than one replaceable hydrogen atom in a given structure is replaced by specific substituent groups. A substituted group may have a substituent at each replaceable position within the group, and when more than one position in a given structural formula can be replaced by one or more substituents of a specific substituent group, the substituent is the same or different at each position.

[015] In the present invention, “Ca-Cb alkyl” means a linear or branched saturated alkyl group containing from a to b carbon atoms, such as methyl, ethyl, propyl and isopropyl, etc. For example, “C1-C5 alkyl” means a linear or branched saturated alkyl group containing from 1 to 5 carbon atoms.

[016] In the present invention, “CH=CH” means an HC=CH- structural fragment of an alkene and “(CH=CH)m” means a conjugated alkene fragment consisting of m-HC=CH- units linked by single bonds.

[017] Documents GB987715A, GB190708576A, GB190708643A and GB182446A discloses the processes for preparing an existing Al salt of an organic acid, and these processes and variations thereof can be used to prepare the aforementioned organic acid metal compounds, wherein when R2 and R3 involved in the structure thereof are not OH, R2 and R3 may be the same as or different from R1. Petition 870250085925, dated 09 / 23 / 2025, page 14 / 157 6 / 36

[018] The physical form of the organic acid metal compound provided in the present invention may be a monomer or a polymer.

[019] The monomer involved in the present invention indicates an organic acid metal compound having a molecular formula of Al(R1)(R2)(R3).

[020] The polymer involved in the present invention indicates an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)n, wherein n is a natural number greater than 2.

[021] In some preparation schemes, reaction substrates that have multiple reactive functional groups can lead to reaction selectivity issues during a reaction, resulting in the product obtained by the preparation scheme of the organic acid metal compounds mentioned above consisting of one or more compounds that have molecular formulas of Aln(R1)n(OH)n(OH)n, Aln(R1)n(R2)n(OH)n and Aln(R1)n(R2)n(R3)n, wherein R1 is selected from YC(O)O or a plant polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- or a plant polyphenol; and preferably, R1, R2 and R3 in this preparation scheme represent YC(O)O or a plant polyphenol.

[022] The “plant polyphenol” involved in the present invention refers to a secondary metabolite having a polyphenolic structure that is derived from a natural plant, including, but not limited to, curcumin, grape polyphenol, ellagic acid, magnolol, a Corni fructus extract, tea polyphenol, hydrolyzable tannin, chestnut tannin, grapefruit tannin and tannic acid.

[023] In some particular preparation schemes, the aforementioned product preferably consists of one or more compounds having a molecular formula of Aln(R1)n(OH)n(OH)n, Aln(R1)n(R1)n(OH)n and Aln(R1)n(R1)n(R1)n, wherein R1, R2 and R3 in this preparation scheme represent YC(O)O- or a plant polyphenol.

[024] In some preparation schemes, the resulting product is an organic acid metal compound in which R1 is selected from a plant polyphenol, and each of R2 and R3 is independently selected from -OH or a plant polyphenol. Petition 870250085925, dated 09 / 23 / 2025, page 15 / 157 7 / 36

[025] In some particular preparation schemes, the resulting product is an organic acid metal compound in which R1 is selected from tannic acid, and each of R2 and R3 is independently selected from -OH or tannic acid.

[026] The “tannic acid” involved in the present invention refers to tannin obtained from Galla chinensis, also known as gallotannin, digallic acid, tannis or tannin.

[027] In some preparation schemes, the resulting product is an organic acid metal compound wherein R1 is selected from YC(O)O-, and each of R2 and R3 is independently selected from -OH or YC(O)O, wherein Y is selected from linear or branched C1-C15 alkyl or linear or branched C1-C15 alkyl substituted by 1-5 R4, and R4 is -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I.

[028] In some embodiments, the resulting product is an organic acid metal compound in which R1 is selected from YC(O)O-, and each of R2 and R3 is independently selected from -OH or YC(O)O-, in which Y is selected from C4-C5 cycloheteroalkyl or C4-C5 cycloheteroalkyl substituted by 1-5 R4, and R4 is -OH, -NH2, -CN, -SH or -X1, in which X1 is selected from F, Cl, Br or I.

[029] In some embodiments, the resulting product is an organic acid metal compound in which R1 is selected from YC(O)O-, and each of R2 and R3 is independently selected from -OH or YC(O)O-, in which Y is selected from phenyl or 1-5 substituted phenyl R5, and R5 is -OH, -NH2, NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1-C5 X2-substituted alkyl, in which X2 is selected from F, Cl, Br or I.

[030] In some embodiments, the resulting product is an organic acid metal compound in which R1 is selected from YC(O)O-, and each of R2 and R3 is independently selected from -OH or YC(O)O-, in which Y is selected from C4-C5 heteroaryl or C4-C5 heteroaryl substituted by 1-5 R5, in which the heteroaryl contains O, S or N, and R5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1-C5 alkyl X2-substituted, in which X2 is selected from F, Cl, Br or I. Petition 870250085925, dated 09 / 23 / 2025, p. 16 / 157 8 / 36

[031] In some embodiments, in the organic acid metal compound and / or the solvate thereof, Y is 3-pyridyl.

[032] In some embodiments, in the organic acid metal compound and / or in the solvate thereof, R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH and YC(O)O-, Y is selected from -(CH=CH)m-phenyl or -(CH=CH)m-phenyl wherein the phenyl is substituted by 1-5 R5, m is any natural number, and R5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1-C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I.

[033] In some embodiments, in the organic acid metal compound and / or in the solvate thereof, R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH and YC(O)O-, and Y is selected from -(CH=CH)-phenyl.

[034] In some embodiments, in the organic acid metal compound and / or in the solvate thereof, the solvate of the organic acid metal compound is selected from one, more than one, or a combination of a hydrate, an acetone solvate, an ethanol solvate, a methanol solvate, a dimethyl sulfoxide solvate, an ethyl acetate solvate, an acetic acid solvate, and / or an isopropanol solvate of the organic acid metal compound;

[035] In some embodiments, the organic acid metal compound and / or its solvate is selected from one or more individual organic acid metal compounds having the same or different molecular formulas, one or more individual solvates of organic acid metal compounds having the same or different molecular formulas, or a combination of one or more organic acid metal compounds having the same or different molecular formulas and one or more solvates of organic acid metal compounds having the same or different molecular formulas.

[036] In some embodiments, the organic acid metal compound includes an organic acid metal compound monomer or an organic acid metal compound polymer. Petition 870250085925, dated 09 / 23 / 2025, p. 17 / 157 9 / 36

[037] In some of the preparation examples, the organic acid metal compound is one of the compounds that have molecular formulas as follows:

[038] Aln(OH)2n(CH3COO)n (abbreviated as “Al acetate”), Aln(OH)2n(CH3(CH2)2COO)n (abbreviated as “Al butyrate”), Aln(OH) 2n(CH3(CH2)8COO)n (abbreviated as “Al caprate”), Aln(OH)2n(CH3(CH2)i2COO)n (abbreviated as Ί4ΑΓ), Aln(OH)2n(CH3(CH2)i4COO)n(abbreviated as “palmate of Aln(OH)2n Al”), (abbreviated as “Al benzoate”), Aln(OH)2n (abbreviated as “NAI”), (abbreviated as “KAI”), en (abbreviated as “RAI”).

[039] In some of the preparation examples, the organic acid metal compound is one of the following combinations:

[040] “Al acetate combination” is a combination of one or more of Aln(OH)2n(CH3COO)n, Aln(OH)n(CH3COO)2n and Aln(CH3COO)3n;

[041] “Al butyrate combination” is a combination of one or more of Petition 870250085925, dated 09 / 23 / 2025, page 18 / 157 10 / 36 that one of Aln(OH)2n(CH3(CH2)2COO)n, Aln(OH)n(CH3(CH2)2COO)2n and Aln(CH3(CH2)2COO)3n;

[042] “Al caprate combination” is a combination of one or more of Aln(OH)2n(CH3(CH2)8COO)n, Aln(OH)n(CH3(CH2)8COO)2n and Aln(CH3(CH2)8COO)3n;

[043] “14AI combination” is a combination of one or more of Aln(OH)2n(CH3(CH2)l2COO)n, Aln(OH)n(CH3(CH2)l2COO)2n and Aln(CH3(CH2)i2COO)3n;

[044] “Al palmate combination” is a combination of one or more of Aln(OH)2n(CH3(CH2)i4COO)n, Aln(OH)n(CH3(CH2)i4COO)2n and Aln(CH3(CH2)i4COO)3n;

[045] “Al benzoate combination” is a combination of one or more and

[046] “NAI combination” is a combination of one or more of Petition 870250085925, dated 09 / 23 / 2025, page 19 / 157 11 / 36

[048] and “RAI combination” is a combination of one or more of

[049] The “organic acid metal compound” involved in the present invention includes an organic acid metal compound monomer or an organic acid metal compound polymer, and also includes a combination of one or more organic acid metal compounds having the same or different molecular formulas.

[050] In some embodiments, the process of preparing the organic acid metal compound additionally involves the separation process, Petition 870250085925, dated 09 / 23 / 2025, page 20 / 157 12 / 36 Purification or recrystallization of a reaction product. Regarding the reaction product, a crude product can be obtained from a reaction system through a desolvation method; and in order to obtain a solid substance that has higher chemical purity and lower impurity content, under suitable conditions such as appropriate temperature, illumination, and mechanical vibration, the crude product is dissolved, crystallized or precipitated or recrystallized in an alcohol solvent, a mixed alcohol-water solvent, or other organic solvents that can be used to recrystallize the product, and separated to obtain an organic acid metal compound that has a certain material form.

[051] The organic acid metal compound that has a certain physical form is a solvate of the organic acid metal compound. The solvate of the organic acid metal compound may be selected from a hydrate, an acetone solvate, an ethanol solvate, a methanol solvate, a dimethyl sulfoxide solvate, an ethyl acetate solvate, an acetic acid solvate, or an isopropanol solvate of the organic acid metal compound.

[052] The “solvate” involved in the present invention refers to a cocrystalline association compound formed by the linking of stoichiometric or non-stoichiometric solvent molecules to the compound of the present invention through non-covalent intermolecular forces caused by external and internal conditions in the process of bringing the compound into contact with the solvent molecules. Solvents for forming solvates include, but are not limited to, water, acetone, ethanol, methanol, dimethyl sulfoxide, ethyl acetate, acetic acid, isopropanol, etc. The “hydrate” refers to a complex or crystal formed by water as a solvent molecule, that is, a compound to which stoichiometric or non-stoichiometric water is linked through non-covalent intermolecular forces.

[053] The “organic acid metal compound and / or solvate thereof” involved in the present invention is selected from one or more individual organic acid metal compounds having the same or different molecular formulas, one or more individual solvates of organic acid metal compounds having the same or different molecular formulas, or a Petition 870250085925, dated 09 / 23 / 2025, p. 21 / 157 13 / 36 combination of one or more organic acid metal compounds having the same or different molecular formulas and one or more solvates of organic acid metal compounds having the same or different molecular formulas.

[054] Experiments to study the bioavailability of the organic acid metal compound provided in the present invention include: an experiment to study the effect of the organic acid metal compound and its solvate on the growth performance of piglets, an experiment to study the effect on the growth performance of broiler chickens, an experiment to study the effect on the production performance of laying hens, and an experiment to study the effect of application in feed for ducks intended for meat production. The research results show that the organic acid metal compound and its solvate can effectively intensify / reduce / improve the growth rate, feed conversion rate, growth efficiency, and growth of pigs, chickens, and ducks in farmland.

[055] The present invention further studies residual elemental Al in the muscles or tissues of poultry suitable for roasting, ducks intended for meat production, pigs and laying hens when the organic acid metal compound and its solvate are used in the feed of the aforementioned animals. The results show that, in a long-term feeding experiment of 3 to 6 months, the residual elemental Al content of the organic acid metal compound remaining in the animals' bodies is lower than in the blank control group or lower than the detection limit of instrument devices, which sufficiently indicates that the organic acid metal compound and its solvate of the present invention can be used in feed for poultry suitable for roasting, ducks intended for meat production, pigs and laying hens, and have no residual elemental Al remaining in the muscles or tissues of the aforementioned animals. USE OF ORGANIC ACID METAL COMPOUNDS INVOLVED IN THE PRESENT INVENTION

[056] Based on the results of the study of the bioavailability of the organic acid metal compound and its solvate and the results of the study of the residue of the organic acid metal compound and its solvate Petition 870250085925, dated 09 / 23 / 2025, page 22 / 157 14 / 36 in the body of animals, the present invention provides the use of the organic acid metal compound and / or the solvate thereof as an animal feed additive or in the preparation of an animal feed additive.

[057] The “animal” involved in the present invention refers to farm animals that cannot convert inorganic matter into organic matter, but can only use organic matter as food or feed to perform vital activities such as ingestion, digestion, absorption, respiration, circulation, excretion, sensation, movement, and reproduction. “Farm animals” include poultry, livestock, aquaculture animals, and other animals that are raised in captivity and are legally captured, including domestic animals such as cats and dogs. The term “livestock” refers to, for example, any of the following: pigs, cattle, horses, goats, sheep, deer, and many useful rodents. The term “poultry” includes, for example, chickens, ducks, geese, quail, and pigeons. The term “aquaculture animals” includes, for example, fish, shrimp, turtles, and softshell turtles.

[058] The organic acid metal compounds and / or solvates thereof provided in the present invention are used as or in the preparation of growth promoters for animals at various stages of growth, wherein the animals may be selected from among cattle, poultry, aquaculture animals or other animals including domestic animals at various stages of growth.

[059] Additionally, livestock includes, but is not limited to, pigs, cattle, sheep, deer, horses, rabbits, mink or donkeys; domestic fowl includes, but is not limited to, chickens, turkeys, ducks, geese, quail or pigeons; aquaculture animals include, but is not limited to, fish, shrimp, turtles, crabs, softshell turtles, bullfrogs, eels or loaches; and domestic animals include, but is not limited to, dogs or cats of various subspecies.

[060] In one embodiment, the organic acid metal compound and / or the solvate thereof provided in the present invention is used as or in the preparation of a feed additive to improve the production performance of sows, wherein the feed additive has significant effects on improving both daily gain Petition 870250085925, dated 09 / 23 / 2025, page 23 / 157 15 / 36 average of the feed conversion rate of the sows.

[061] In another embodiment, the organic acid metal compound and / or the solvate thereof provided in the present invention is used as or in the preparation of a feed additive to improve the production performance of roasting poultry or laying hens, wherein the feed additive can significantly improve the production performance of roasting poultry or laying hens.

[062] In another embodiment, the organic acid metal compound and / or the solvate thereof provided in the present invention is used as or in the preparation of a feed additive to improve the production performance of ducks intended for meat production, wherein the feed additive can significantly improve the production performance of ducks intended for meat production.

[063] In another embodiment, the organic acid metal compound and / or the solvate thereof provided in the present invention is used as or in the preparation of a feed additive to improve fish production performance, wherein the feed additive can significantly improve fish production performance. COMPOSITIONS INVOLVED IN THE PRESENT INVENTION

[064] The “composition” involved in the present invention refers to a collection or set comprising one or more compounds, and further refers to a collection or set of compounds comprising one or more compounds as active ingredients or components.

[065] The composition provided in the present invention comprises the aforementioned organic acid metal compound and / or its solvate, and additionally, the composition comprises the aforementioned organic acid metal compound and / or its solvate as an active ingredient or component.

[066] The organic acid metal compound and / or solvate thereof consists of one or more compounds having molecular formulas of Aln(R1)n(OH)n(OH)n, Aln(R1)n(R2)n(OH)n and Aln(R1)n(R2)n(R3)n, wherein R1 is selected from YC(O)O or a vegetable polyphenol, and each of R2 and R3 is Petition 870250085925, dated 09 / 23 / 2025, p. 24 / 157 16 / 36 independently selected from -OH, YC(O)O- or a plant polyphenol; and preferably, the organic acid metal compound and / or the solvate thereof consists of one or more compounds having molecular formulas of Aln(R1)n(OH)n(OH)n, Aln(R1)n(R1)n(OH)n and Aln(R1)n(R1)n(R1)n, wherein R1, R2 and R3 represent YC(O)O- or a plant polyphenol.

[067] Additionally, the composition comprising the aforementioned organic acid metal compound and / or the solvate thereof provided in the present invention further comprises one or a combination of an acceptable feed adjuvant, an additional animal feed additive and an animal feed raw material.

[068] Additionally, in the organic acid metal compound and / or solvate thereof provided in the present invention, the solvate of the organic acid metal compound is selected from one, more than one, or a combination of a hydrate, an acetone solvate, an ethanol solvate, a methanol solvate, a dimethyl sulfoxide solvate, an ethyl acetate solvate, an acetic acid solvate, and / or an isopropanol solvate of the organic acid metal compound.

[069] Furthermore, the aforementioned organic acid metal compound and / or its solvate is selected from one or more individual organic acid metal compounds having the same or different molecular formulas, one or more individual solvates of organic acid metal compounds having the same or different molecular formulas, or a combination of one or more organic acid metal compounds having the same or different molecular formulas and one or more solvates of organic acid metal compounds having the same or different molecular formulas;

[070] Furthermore, the aforementioned organic acid metal compound includes an organic acid metal compound monomer or an organic acid metal compound polymer.

[071] In the present invention, the term “comprises” herein is an open-ended expression encompassing both the content explicitly stated in the present invention and the content of other aspects. Petition 870250085925, dated 09 / 23 / 2025, p. 25 / 157 17 / 36

[072] Furthermore, the acceptable adjuvant in feed is selected from one or more of a carrier, a diluent, an excipient and a vehicle.

[073] The “carrier” involved in the present invention refers to a substance that is acceptable in feed, has the ability to carry active ingredients and improve their dispersibility, and exhibits satisfactory chemical stability and adsorbability, including an organic carrier and an inorganic carrier. The organic carrier is selected from a material containing many crude fibers, including, but not limited to, corn flour, corn cob powder, wheat bran, rice husk powder, defatted rice bran, rice mill by-product, corn stalk powder, peanut shell powder, etc. The inorganic carrier is selected from minerals, further selected from calcium salts and silicon oxides, and is used in the preparation of a trace element premix, including, but not limited to, calcium carbonate, silicates, vermiculite, zeolite, sepiolite, etc.

[074] The “diluent” involved in the present invention refers to a substance that enables additive raw materials to be uniformly distributed in a material, and dilutes the high-concentration additive raw materials in a low-concentration premixed agent or premix, which can separate the trace ingredients from each other and reduce the interaction between active ingredients so as to increase the stability of the active ingredients without affecting the physicochemical properties of the material involved, including an organic diluent and an inorganic diluent. The organic diluent includes, but is not limited to, corn flour, degermed corn flour, dextrose (glucose), sucrose, semolina with bran, salted soybean powder, wheat bran, corn gluten meal, etc.; and the inorganic diluent includes, but is not limited to, limestone, calcium dihydrogen phosphate, bark powder, kaolin (white clay), table salt and sodium sulfate.

[075] The “excipient” involved in the present invention refers to a wetting agent that induces the inherent viscosity of a substance, an adhesive that binds substances together, a disintegrating agent that breaks the entire sheet of a substance into many fine particles, a retention aid that reduces friction between particles, or an anti-adherent agent that prevents the adhesion of materials, including, but not limited to, magnesium stearate, talc powder, oil Petition 870250085925, dated 09 / 23 / 2025, p. 26 / 157 18 / 36 vegetable, magnesium lauryl sulfate, starch, fluid starch paste, water, inorganic salts, dextrin, confectioner's sugar, etc.

[076] The “vehicle” involved in the present invention refers to a solvent necessary to dissolve or disperse a solid, including, but not limited to, water, ethanol, glycerol, etc.

[077] The “feed additive” involved in the present invention refers to a small amount or trace amount of substances added during the processing, production and use of feed, including a nutritional feed additive and a general feed additive, also known as a non-nutritional feed additive.

[078] The “animal feed additive” involved in the present invention refers to one or more of a nutritive feed additive, a general feed additive or a medicinal feed additive.

[079] The “nutritive feed additive” involved in the present invention refers to a small amount or trace amount of substances that are added to formulated feeds to balance feed nutrients, improve feed utilization, and directly exert nutritional effects on animals, including an amino acid, an amino acid salt and an analogue thereof, a vitamin and a vitamin-like substance, a mineral element and a complex (chelate) thereof, a microbial enzyme preparation or a non-protein nitrogen.

[080] The “general feed additive” involved in the present invention, also known as a “non-nutritive additive”, refers to certain non-nutritive substances that are added to feed to improve feed utilization and ensure feed mass and quality, and are beneficial to animal health or metabolism, including a growth promoter, an anti-worming agent, a flavoring and attractant, a feed conditioning agent, a feed formulation agent, a feed preservative, and a Chinese herbal medicine additive.

[081] The “feed” involved in the present invention refers to a product that is industrially processed and produced for consumption by animals. Unless Petition 870250085925, dated 09 / 23 / 2025, p. 27 / 157 19 / 36 otherwise stated, “feed” or “animal feed” includes animal feed raw materials and one or more animal feed additives. In some embodiments, animal feed raw materials include acceptable feed substances such as grains and processed grain products, oilseeds and processed oilseed products, legume crop seeds and processed legume products, stem tubers, root tubers and processed root products, other fruit and seed products and processed fruit and seed products, forage, fiber and processed fiber products, other plants, algae and processed algae, dairy products and by-products thereof, terrestrial animal products and by-products thereof, fish, other aquatic organisms and by-products thereof, minerals, microbial fermentation products and by-products thereof, and other feed raw materials. USE OF COMPOSITIONS

[082] The present invention relates to the use of the aforementioned composition comprising the aforementioned organic acid metal compound and / or the solvate thereof; and additionally, the present invention relates to the use of the aforementioned composition comprising the organic acid metal compound and / or the solvate thereof as an active ingredient or component.

[083] In some embodiments, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as an animal feed additive or in the preparation of an animal feed additive.

[084] The composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as an animal feed additive or in the preparation of an animal feed additive, wherein the animal feed additive is selected from a livestock feed additive, a poultry feed additive, an aquaculture feed additive or a domestic animal feed additive. In particular, the animal feed additive is an animal growth promoter.

[085] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate of Petition 870250085925, dated 09 / 23 / 2025, page 28 / 157 20 / 36 is used as a livestock feed additive or in the preparation of a livestock feed additive, where livestock includes, but is not limited to, pigs, cattle, goats, horses, rabbits, minks, etc. at various stages of growth.

[086] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a feed additive for poultry or in the preparation of a feed additive for poultry, wherein poultry include, but are not limited to, chickens, ducks, geese, pigeons, etc. at various stages of growth.

[087] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as an aquaculture animal feed additive or in the preparation of an aquaculture animal feed additive, wherein aquaculture animals include, but are not limited to, fish, shrimp, crabs, softshell turtles, eels, etc. at various stages of growth.

[088] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a pet food additive or in the preparation of a pet food additive, wherein pet animals include, but are not limited to, dogs or cats bred in captivity.

[089] In particular, the composition or acceptable feed composition comprising the organic acid metal compound and / or its solvate is used as an animal feed additive or in the preparation of an animal feed additive, wherein the animal feed additive prepared from the composition or acceptable feed composition comprising the organic acid metal compound and / or its solvate is selected from a premixed agent, a multi-premixed agent, an aqueous agent or granules.

[090] In some embodiments, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as an animal feed or in the preparation of an animal feed. Petition 870250085925, dated 09 / 23 / 2025, page 29 / 157 21 / 36

[091] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as animal feed or in the preparation of animal feed, wherein the animal feed is selected from livestock feed, poultry feed, aquaculture feed or domestic animal feed.

[092] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a livestock feed or in the preparation of a livestock feed, wherein livestock includes, but is not limited to, pigs, cattle, goats, horses, rabbits, minks, etc. at various stages of growth.

[093] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a feed for domestic poultry or in the preparation of a feed for domestic poultry, wherein domestic poultry include, but are not limited to, chickens, ducks, geese, pigeons, etc. at various stages of growth.

[094] In particular, the composition or acceptable composition in feeds comprising the organic acid metal compound and / or the solvate thereof is used as an aquaculture animal feed or in the preparation of an aquaculture animal feed, wherein the aquaculture animals include, but are not limited to, fish, shrimp, crabs, softshell turtles, eels, etc. at various stages of growth.

[095] In particular, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a pet food or in the preparation of a pet food, wherein the pets include, but are not limited to, dogs or cats bred in captivity.

[096] In some embodiments, the composition or acceptable composition in feed comprising the organic acid metal compound and / or the solvate thereof is used as a feed or in the preparation of a feed, wherein the feed is selected from a single feed, a concentrate feed, a formula feed, a multi-premix or a concentrate supplement. Petition 870250085925, dated 09 / 23 / 2025, page 30 / 157 22 / 36

[097] In particular, formula feed is a complete formula feed. METHOD FOR IMPROVING THE PRODUCTION PERFORMANCE OF FARM ANIMALS

[098] The present invention provides a method for improving the production performance of an animal, wherein the method comprises administering to the animal an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof or comprises administering to the animal a composition comprising an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof as an active component.

[099] In some embodiments, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof, or the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component, is provided for consumption by animals in combination with a feed; and the application of the organic acid metal compound and / or the solvate thereof, or the application of the composition, can significantly improve the production performance of the animals.

[100] In some embodiments, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof is uniformly mixed with an animal feed for consumption by animals.

[101] In some embodiments, the composition comprising the organic acid metal compound and / or the solvate thereof is selected from a premixed agent, a multi-premixed agent, granules or an aqueous agent, and the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component is uniformly mixed with an animal feed for consumption by animals.

[102] In particular, the animals are selected from among livestock, poultry, aquaculture animals or domestic animals.

[103] In particular, livestock includes, but is not limited to, pigs, cattle, Petition 870250085925, dated 09 / 23 / 2025, page 31 / 157 23 / 36 goats, horses, rabbits, minks, etc. at various stages of growth; domestic poultry includes, but is not limited to, chickens, ducks, geese, pigeons, etc. at various stages of growth; aquaculture animals include, but are not limited to, fish, shrimp, crabs, softshell turtles, eels, etc. at various stages of growth; and domestic animals include, but are not limited to, dogs or cats raised in captivity.

[104] In one embodiment, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof, or the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component, is provided for consumption by weaned pigs in combination with a ration, which can significantly improve the average daily gain weight gain rate and feed conversion rate of weaned pigs.

[105] In one embodiment, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof, or the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component, is provided for consumption by roast poultry in combination with a feed, which can significantly reduce the feed conversion ratio and improve the feed conversion rate of roast poultry.

[106] In one embodiment, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof, or the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component, is provided for consumption by fish in combination with a feed.

[107] In one embodiment, the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)n and / or the solvate thereof, or the composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)n and / or the solvate thereof as a Petition 870250085925, dated 09 / 23 / 2025, p. 32 / 157 The 24 / 36 active component is provided for consumption by canine puppies in combination with a diet.

[108] In some other embodiments, the aforementioned composition comprising the organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or the solvate thereof as an active component is provided for consumption by animals, which can significantly improve the animals' production performance.

[109] Optionally, the composition is selected from a premixed feed additive agent, a multi-premixed feed additive agent, granules or an aqueous agent and / or is provided for animal consumption in combination with a feed.

[110] In one embodiment, the composition is a premixed agent of a feed additive.

[111] In one embodiment, the composition is a multi-premixed feed additive agent.

[112] Optionally, the composition is a concentrate feed, a formula feed, a multi-premix or a concentrate supplement, or it is provided directly as an animal feed for consumption by animals.

[113] In one embodiment, the composition is a complete formula ration. DETAILED DESCRIPTION OF EMBODIMENTS

[114] In order to make the purposes, technical solutions and advantages of the present invention clearer, the compounds, compositions and uses of the present invention are further illustrated in detail below by way of example. It should be understood that the specific examples described herein are merely used to explain the present invention, but are not intended to limit the present invention.

[115] EXAMPLE 1 EFFECT OF ORGANIC ACID METAL COMPOUNDS ON PIGLET GROWTH PERFORMANCE

[116] Two hundred 45-day-old heterozygous DurocxLandracexYorkshire lean piglets with similar weights were randomly divided into 10 Petition 870250085925, dated 09 / 23 / 2025, page 33 / 157 25 / 36 treatment groups, with 2 replicates per group and 10 piglets per replicate (half male and half female). The specific grouping is shown in Table 1. The pigsty and utensils were disinfected before the experiment. During the experimental period, the animals were kept in separate pens in the same pigsty under the same rearing and management conditions. During the experiment, the experimental piglets had free access to food and water. Group A was the blank control group, fed only nursery rations; and experimental groups BH were fed nursery rations containing different organic acid metal compounds, respectively. No additional antioxidant ingredients or growth promoters were added to each experimental group throughout the rearing process. The experimental period was 28 days, and the growth performance of the experimental piglets was recorded.The average daily feed intake (ADFI, g / d*number of piglets), average daily gain (ADG, g / d*number of piglets) and feed conversion ratio (FCR) of the experimental piglets were expressed as “average values”, as shown in Table 1.

[117] Feed conversion ratio (FCR) = average daily feed intake / average daily gain; Weight gain ratio = (ADG of experimental group - ADG of control group) / ADG of control group*100 %;

[118] Rate of increase in feed intake = (ADFI of experimental group - ADFI of control group) / ADFI of control group*100 %;

[119] Rate of decrease in feed conversion ratio = (FCR of control group - FCR of experimental group) / FCR of control group*100 %.

[120] TABLE 1 EFFECT OF ORGANIC ACID METAL COMPOUNDS ON PIGLET GROWTH PERFORMANCE Item Sample Quantity / Addition (ppm) Number of experiments ADFI Rate of increase in feed intake (%) ADG Rate of weight gain (%) FCR Rate of decrease in feed conversion ratio (%) Group A 0 10*2 706 - 351 - 2.01 - Petition 870250085925, dated 09 / 23 / 2025, page 34 / 157 26 / 36 Group B Al acetate / 1000 10*2 713 0.99 394 12.25 1.81 10.03 Group C Al butyrate / 500 10*2 794 12.46 441 25.64 1.80 10.49 Group D Al caprate / 2000 10*2 760 7.65 419 19.37 1.81 9.82 Group E 14Al / 1000 10*2 733 3.82 411 17.09 1.78 11.33 Group F Al palmate / 1000 10*2 757 7.22 419 19.37 1.81 10.18 Group G Al benzoate / 1000 10*2 780 10.48 438 24.79 1.78 11.46 Group H NAl / 500 10*2 762 7.93 430 22.51 1.77 11.90 Group I KAl / 500 10*2 726 2.83 406 15.67 1.79 11.10 Group J RAl / 500 10*2 721 2.12 399 13.68 1.81 10.16

[121] The above results showed that the organic acid metal compounds involved in the experiment had obvious effects on improving or intensifying the feed conversion ratio of the experimental piglets, as represented by a decrease of 9.82% to 11.90% in the feed conversion ratio compared to the blank control group. Furthermore, in terms of weight gain, the average daily gain of the experimental group increased by 12.25%-25.64% compared to that of the blank control group, and in terms of feed intake, Al butyrate, Al caprate, Al palmate, Al benzoate and NAl can increase the feed intake of the experimental piglets to varying degrees.

[122] EXAMPLE 2 EFFECT OF ORGANIC ACID METAL COMPOUNDS ON GROWTH PERFORMANCE OF POULTRY SUITABLE FOR ROASTING

[123] In the experiment, a single-factor randomized design was used. Six hundred one-day-old three-yellow roast chickens (yellow-downed roast chickens) of similar weights (mean weight 50 g) were randomly divided into 10 treatment groups, with 3 replicates per group and 20 three-yellow roast chickens (yellow-downed roast chickens) per replicate (half male and half female). The grouping is shown in Table 2. The chicken coops and utensils were disinfected before the Petition 870250085925, dated 09 / 23 / 2025, page 35 / 157 27 / 36 experiment. During the experimental period, the animals were caged in the same henhouse under the same rearing and management conditions. The basal diet was primarily corn-soybean meal, and no additional antioxidant ingredients or growth promoters were added throughout the rearing process. Experimental group A was the control group, fed only the basal diet; and experimental groups BH were fed the basal diet plus 250 ppm of organic acid metal compounds, respectively, as shown in Table 2. The experimental period was 20 days in total. The experimental roasting birds had free access to food and water and were fed twice a day.With each replicate as a unit, roast-ready birds were weighed at 21 days of age (feed withheld for 12 h, but allowed access to water), feed consumption of experimental roast-ready birds was recorded, and average daily feed intake (ADFI, g / d*number of roast-ready birds), average daily gain (ADG, g / d*number of roast-ready birds) and feed conversion ratio (FCR) of experimental roast-ready birds in each group were calculated according to the following calculation formulas:.

[124] Feed conversion ratio (FCR) = average daily feed intake / average daily gain;

[125] Rate of weight gain = (ADG of experimental group - ADG of control group) / ADG of control group*100 %;

[126] Rate of increase in feed intake = (ADFI of experimental group - ADFI of control group) / ADFI of control group*100 %;

[127] Rate of decrease in feed conversion ratio = (FCR of control group - FCR of experimental group) / FCR of control group*100 %.

[128] The experimental results were as shown in Table 2.

[129] TABLE 2 EFFECT OF APPLICATION OF ORGANIC ACID METAL COMPOUNDS IN POULTRY FEEDS SUITABLE FOR ROASTING Petition 870250085925, dated 09 / 23 / 2025, page 36 / 157 28 / 36 Item Sample / Quantity added (ppm) ADFI Rate of increase in feed intake (%) ADG Rate of weight gain (%) FCR Rate of decrease in feed conversion ratio (%) Group A 0 29.8 - 11.2 - 2.66 - Group B Al acetate / 1000 33.5 12.42 14.3 27.68 2.34 11.95 Group C Al butyrate / 500 34.9 17.11 15.1 34.82 2.31 13.13 Group D Al caprate / 250 38.7 29.87 16.9 50.89 2.29 13.94 Group E 14Al / 100 35.1 17.79 15.3 36.61 2.29 13.78 Group F Al palmate / 250 33.8 13.42 14.7 31.25 2.30 13.58 Group G Al / 250 benzoate 35.3 18.46 15.3 36.61 2.31 13.29 Group H NAl / 250 34.5 15.77 15.0 33.93 2.30 13.56 Group I KAl / 250 32.6 9.40 14.1 25.89 2.31 13.10 Group J RAl / 250 34.5 15.77 15.1 34.82 2.28 14.13

[130] The above results showed that the organic acid metal compounds involved in the experiment had obvious effects on improving or intensifying feed intake, average daily gain, and feed conversion ratio of experimental roast-fit birds, and experimental roast-fit birds in the experimental groups had a 9.40%-29.87% increase in feed intake, a 25.89%-50.89% increase in average daily gain, and an 11.95%-14.13% decrease in feed conversion ratio compared with those in the blank control group.

[131] EXAMPLE 3 STUDY ON THE USE OF ORGANIC ACID METAL COMPOUNDS IN DUCK FEEDS INTENDED FOR MEAT PRODUCTION

[132] A single-factor experimental design was used. Forty-eight 1-day-old Cherry Valley ducks of substantially the same weight and satisfactory health status intended for meat production were Petition 870250085925, dated 09 / 23 / 2025, p. 37 / 157 29 / 36 ducks were selected and randomly divided into 8 treatment groups, with 3 replicates per group and 20 ducks per replicate. The control group was a blank diet group, fed a basal diet (corn-soybean meal type); and other treatment groups were all sample addition groups, fed the basal diet plus different organic acid metal compounds, respectively. The experimental period was 42 days in total. See Table 3 for specific animal grouping. During the experiment, the experimental ducks had free access to food and water, and were immunized according to conventional immunization procedures, and feed intake, feed consumption, exclusion due to death, etc. in each group were observed and recorded daily. The ducks were weighed fasting at the beginning and end of the experiment.After the experiment ended, with each replicate as a unit, the average daily gain, average daily feed intake, and the ratio between feed intake / weight and animal weight gain were statistically analyzed for each treatment group, and the results are as shown in Table 3.

[133] TABLE 3 EFFECT OF APPLICATION OF ORGANIC ACID METAL COMPOUNDS IN DUCKS FEED FOR MEAT PRODUCTION Item Sample / Quantity added (ppm) Average daily feed intake (g / d) Rate of increase in feed intake (%) Average daily gain (g / d) Rate of weight gain (%) Feed conversion ratio Rate of decrease in feed conversion ratio (%) Group A 0 179 - 76.27 - 2.35 - Group B Al acetate / 500 192 7.26 91.33 19.75 2.10 10.42 Group C Al butyrate / 250 205 14.53 98.87 29.63 2.07 11.65 Group D Al caprate / 250 189 5.59 90.81 19.06 2.08 11.32 Group E 14Al / 100 212 18.44 101.35 32.88 2.09 10.87 Group F Al palmate / 250 198 10.61 95.86 25.69 2.07 11.99 Petition 870250085925, dated 09 / 23 / 2025, page 38 / 157 30 / 36 Group G Al benzoate / 250 221 23.46 105.94 38.90 2.09 11.11 Group H NAl / 250 208 16.20 100.36 31.59 2.07 11.69

[134] The above results showed that the organic acid metal compounds involved in the experiment had obvious effects on improving or intensifying feed intake, average daily gain, and feed conversion ratio of the experimental ducks, and the experimental ducks in the experimental groups had a 7.26%-23.46% increase in feed intake, a 19.06%-38.90% increase in average daily gain, and a 10.42%-11.99% decrease in feed conversion ratio compared with those in the blank control group.

[135] EXAMPLE 4 STUDY ON THE EFFECT OF COMPOUND AL BENZOATE ON THE PRODUCTION PERFORMANCE OF LAYING HENS

[136] For laying hen broods (38,395 277-day-old Hy-Line gray hens) that have stable production performance, normal production data were collected for two consecutive weeks, and then Al benzoate compounds (abbreviated as “Al benzoate”) (500 g / ton) were added to a complete formula ration to observe for 33 days. After that, the experiment was carried out for another 33 days using the complete formula ration without adding Al benzoate. Data such as egg production, exclusion due to death, feed consumption, temperature and humidity were collected daily, and summarized once approximately every two weeks as an experimental phase. The entire experiment consisted of five phases, namely, pre-control phase (14 days), Al benzoate phase I (14 days), Al benzoate phase II (19 days), post-control phase I (14 days) and post-control phase II (19 days).In addition, some eggs were randomly collected each week and tested for eggshell thickness and strength.

[137] Detailed production performance data were as follows: (1) increase in egg production rate: the egg production rate of laying hen broods increased from 91.71% in the pre-control phase to 93.57% (Al benzoate phase I) and 93% (Al benzoate phase II); and after the Petition 870250085925, dated 09 / 23 / 2025, page 39 / 157 31 / 36 suspension, the egg production rate decreased to 91.72% (post-control phase I) and 91.96% (post-control phase II), which was comparable to that in the pre-control phase; (2) improvement in the feed-to-egg ratio: the feed-to-egg ratio in the pre-control phase was 2.063:1; the feed-to-egg ratio in the experimental phases was significantly improved and decreased to 2.0:1 (Al benzoate phase I) and 1.970:1 (Al benzoate phase II); and after the withholding of Al benzoate, the feed-to-egg ratio was 1.976 (post-control phase I) and 1.996 (post-control phase II), respectively; (3) decrease in daily feed intake: after using Al benzoate, the average daily feed intake decreased from 116.79 g to 115.27 g (Al benzoate phase I) and 112.69 g (Al benzoate phase II); and (4) no significant change in eggshell thickness.

[138] Comprehensive statistics of experimental data showed that the use of Al benzoate in laying hen broods provided increased intestinal health, increased egg production rate, decreased feed-to-egg ratio, decreased daily feed intake, and a downward trend in average egg weight. Furthermore, after discontinuing Al benzoate, laying hen broods still showed an improved trend in production performance, suggesting a sustained residual effect.

[139] EXAMPLE 5 ANALYSIS AND STUDY OF RESIDUES OF DIFFERENT ORGANIC ACID METAL COMPOUNDS IN DIFFERENT ANIMALS

[140] I. Experimental animals: Roasting birds with white feathers (1 day old), roasting birds with yellow down (1 day old), ducks intended for meat production (1 day old), pigs (15 kg), and laying hens (eggs)

[141] II. Experimental method: 1. High levels of organic acid metal compounds were added to a ration, and muscle or tissue samples were collected at different days of age in a long-term feeding experiment of 3-6 months and detected for Al content, as shown in Tables 4-10. 2. The experimental design included a blank control group without the Petition 870250085925, dated 09 / 23 / 2025, page 40 / 157 32 / 36 addition of metal compounds to organic acid. 3. The Al content in the feed after the addition of different organic acid metal compounds was tested.

[142] III. Experimental results

[143] (I) Experimental results of birds suitable for roasting with white down

[144] TABLE 4 RESULTS OF DETECTION OF OWN BIRDS FOR ROASTING WITH WHITE DOWN (40 DAYS OLD) Sample added and dosage (g / kg of feed) Leg muscle (ppm) Pectoral muscle (ppm) Liver (ppm) Blank control group ND ND ND Al-4.0 g / kg ND ND ND Al-2.0 g / kg ND ND ND Al benzoate-2.0 g / kg ND ND ND Al butyrate-2.0 g / kg ND ND ND Al-1.0 g / kg ND ND ND Notes: the detection limit is 0.5 ppm, and “ND” means no Al detected.

[145] (II) Experimental results of birds suitable for roasting with yellow down

[146] TABLE 5 RESULTS OF DETECTION OF BIRDS SUITABLE FOR ROASTING WITH YELLOW DOWN AT 40 DAYS OF AGE Sample added and dosage (g / kg of feed) Leg muscle (ppm) Pectoral muscle (ppm) Liver (ppm) Fat (ppm) Commercially available roasting poultry 0.98 Blank control group 1.7 1.6 1.4 1.5 TAl-0.6 g / kg 0.97 0.92 ND 0.83 TAl-1.2 g / kg ND ND 1.0 0.95 TAl-2.4 g / kg 0.84 ND ND 1.1 14Al-0.3 g / kg ND ND ND 0.97 14Al-1.0 g / kg ND ND ND 1.2 Petition 870250085925, dated 09 / 23 / 2025, page 41 / 157 33 / 36 Al benzoate - 1.0 g / kg ND ND ND 1.4 Al benzoate - 2.0 g / kg 1.1 1.2 ND 0.96 Al butyrate - 2.0 g / kg 0.84 1.0 ND 0.8 N Al - 1.0 g / kg ND ND ND ND Notes: The detection limit is 0.5 ppm, and "ND" means no Al detected.

[147] TABLE 6 RESULTS OF DETECTION OF OWN BIRDS For roasting with yellow down at 80 days old Sample added and dosage (g / kg of feed) Leg muscle (ppm) Pectoral muscle (ppm) Liver (ppm) Fat (ppm) Feed (ppm) Control group (blank) 1.9 1.48 0.752 7.2 143 TAl-0.6 g / kg ND 0.676 ND 0.89 173 TAl-1.2 g / kg ND 0.950 ND ND 209 TAl-2.4 g / kg 0.9 1.12 0.511 1.4 211 14Al-0.3 g / kg ND 1.0 0.88 1.1 168 14Al-1.0 g / kg 0.95 1.05 ND 1.2 179 Al benzoate-1.0 g / kg ND 0.728 ND 1.6 169 Al benzoate 2.0 g / kg ND ND ND 1.1 243 Al butyrate 2.0 g / kg 1.0 0.539 ND 2.7 240 NAl 1.0 g / kg 3.9 0.518 ND 1.7 239 Notes: the detection limit is 0.5 ppm, and “ND” means no Al detected.

[148] TABLE 7 RESULTS OF DETECTION OF OWN BIRDS For roasting with yellow down at 120 days old Sample added and dosage (g / kg of feed) Leg muscle (ppm) Pectoral muscle (ppm) Liver (ppm) Fat (ppm) Egg (ppm) Blank control group 2.2 2.3 2.24 2.5 6.6 TAl-0.6 g / kg ND ND 1.49 ND ND TAl-1.2 g / kg ND ND ND ND ND TAl-2.4 g / kg ND 2.7 ND ND ND Petition 870250085925, dated 09 / 23 / 2025, page 42 / 157 34 / 36 14Al-0.3 g / kg ND ND ND ND ND 14Al-1.0 g / kg ND ND ND 1.3 ND Al benzoate-1.0 g / kg ND ND ND ND ND Al benzoate-2.0 g / kg 2.1 ND 1.98 ND ND Al butyrate-2.0 g / kg 0.82 1.0 1.57 ND ND NAl-1.0 g / kg 1.8 ND 1.32 0.86 ND Notes: the detection limit is 0.5 ppm, and “ND” means no Al detected.

[149] (III) Experimental results from laying hens

[150] The Al content in eggs was the Al content detected in eggs before use or 1-4 weeks after use of organic acid metal compounds.

[151] TABLE 8 RESULTS OF AL CONTENT DETECTION IN EGGS Sample Before use (ppm) 1 week after use (ppm) 2 weeks after use (ppm) 3 weeks after use (ppm) 4 weeks after use (ppm) Blank control group 6.6 4.0 6.5 5.4 3.3 TAl-0.6 g / kg ND ND ND ND ND TAl-1.2 g / kg ND ND ND ND ND TAl-2.4 g / kg ND ND ND ND ND 14Al-0.3 g / kg ND ND ND ND ND 14Al-1.0 g / kg ND ND ND ND ND Al benzoate 1.0 g / kg ND ND ND ND ND Al benzoate 2.0 g / kg ND ND ND ND ND Al butyrate 2.0 g / kg ND ND ND ND ND NAl-1.0 g / kg ND ND ND ND ND Notes: the detection limit is 0.5 ppm, and “ND” means no Al detected.

[152] (IV) Experimental results from ducks Petition 870250085925, dated 09 / 23 / 2025, page 43 / 157 35 / 36

[153] TABLE 9 RESULTS OF DUCK SAMPLE DETECTION (40 DAYS OLD) Sample added and dosage (g / kg of feed) Leg muscle (ppm) Pectoral muscle (ppm) Liver (ppm) Blank control group 2.14 2.21 1.19 TAL-4.0 g / kg 1.31 1.55 0.74 14Al-2.0 g / kg 1.30 1.14 0.90 Al benzoate-2.0 g / kg 0.79 1.04 0.43 Al butyrate-2.0 g / kg 0.64 1.28 1.08 NAl-1.0 g / kg 0.57 0.95 0.88 Notes: the detection limit is 0.5 ppm, and “ND” means no Al detected.

[154] (V) Experimental results from pigs

[155] TABLE 10 SUMMARY OF RESULTS OF DETECTION OF EXPERIMENTAL PIG SAMPLES Sample Dosage (g / kg) First time (40 days) (ppm) Second time (120 days) (ppm) Third time (180 days) (ppm) Muscle (leg) Liver Muscle (leg) Muscle (back) Liver Muscle (leg) Muscle (back) Blank control 0 ND ND 103 ND ND ND ND ND ND Al 5 ND ND 362 ND ND ND ND ND ND 14 Al 2 ND ND 225 ND ND ND ND ND ND Al benzoate 4 ND ND 476 ND ND ND ND ND ND Al butyrate 3 ND ND 528 ND ND ND ND ND ND Notes: The detection limit is 0.5 ppm, and "ND" means no Al detected.

[156] In the present invention, it is confirmed, through livestock activity experiments, that the organic acid metal compound and / or the solvate thereof provided in the present invention can effectively cause animals to gain weight and increase the feed conversion rate, and has a satisfactory effect. Petition 870250085925, dated 09 / 23 / 2025, page 44 / 157 36 / 36 in improving animal production performance; and most notably, the organic acid metal compound and / or the solvate thereof provided in the present invention basically leaves no residue remaining in the muscles, liver and other tissues of animal-derived food products, and the elemental aluminum content is below the instrumental detection limit of detection institutions for elemental aluminum or below the elemental aluminum content in commercially available meat products or below the elemental aluminum content in the meat of edible animals in a blank control group not receiving organic acid metal compounds, which satisfies the requirements for the residual amount of aluminum in food specified in GB 2760-2014 (standard for uses of food additives) [residual amount of aluminum < 100 mg / kg (equivalent to 100 ppm), (dry sample, in terms of Al)].

[157] The above samples merely represent various embodiments of the present invention, providing specifics and details thereof, but should not be understood as limiting the scope of the present invention in this way. It should be noted that a person of ordinary skill in the art may also need to make various alterations and improvements without departing from the spirit of the present invention, and these would all be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be in accordance with the appended claims. Petition 870250085925, dated 09 / 23 / 2025, page 45 / 157

Claims

1 / 6 CLAIMS 1. Use of an organic acid metal compound characterized in that it has a molecular formula of Aln(R1)n(R2)n(R3)ne and / or a solvate thereof as an animal feed additive or in the preparation of an animal feed additive: wherein n is any natural number; R1 is selected from YC(O)O- or a vegetable polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- or a vegetable polyphenol;Y is selected from H, linear or branched C1-C19 alkyl or linear or branched C1-C19 alkyl substituted by 1-5 R4, C3-C7 cycloalkyl or C3-C7 cycloalkyl substituted by 1-5 R4, C3-C7 cycloheteroalkyl or C3-C7 cycloheteroalkyl substituted by 1-5 R4, C5-C12 aryl or C5-C12 aryl substituted by 1-5 R5, C5-C12 heteroaryl or C5-C12 heteroaryl substituted by 1-5 R5, -(CH=CH)m-(C5-C12 aryl) or -(CH=CH)m-(C5-C12 aryl) where C5-C12 aryl is substituted by 1-5 R5, -(CH=CH)m-(C5-C12 heteroaryl) or -(CH=CH)m-(C5-C12 heteroaryl) where C5-C12 heteroaryl is substituted by 1-5 R5; m is any natural number; R4 is selected from -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I; and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, C1-C5 alkyl or -C1-C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I.

2. Use, according to claim 1, characterized in that the organic acid metal compound and / or the solvate thereof has a molecular formula of Aln(R1)n(R2)n(R3)n, wherein R1 is selected from a plant polyphenol, each of R2 and R3 is independently selected from -OH or a plant polyphenol, and preferably R1 is tannic acid, and each of R2 and R3 is independently selected from OH or tannic acid.

3. Use according to claim 1, characterized in that the organic acid metal compound and / or the solvate thereof has a molecular formula of Aln(R1)n(R2)n(R3)n, wherein R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH or YC(O)O-, Y is selected from linear or branched C1-C15 alkyl or linear or branched C1-C15 alkyl substituted by 1-5 R4, and R4 is selected from -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I; or, wherein R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH or YC(O)O-, Y is selected from C4-C5 cycloheteroalkyl or C4-C5 cycloheteroalkyl substituted by 1-5 R4, and R4 is selected from -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I;or, wherein R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH or YC(O)O-, Y is selected from phenyl or phenyl substituted by 1-5 R5, and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or -C1-C5 alkyl X2-substituted, wherein X2 is selected from F, Cl, Br, or I; or, wherein R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH or YC(O)O-, Y is selected from C4-C5 heteroaryl or C4-C5 heteroaryl substituted by 1-5 R5, wherein the heteroaryl contains O, S or N, and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1C5 alkoxy, -C1-C5 alkyl, or -C1-C5 alkyl X2-substituted, wherein X2 is selected from F, Cl, Br or I; preferably, Y is 3-pyridyl;or, wherein R1 is selected from YC(O)O-, each of R2 and R3 is independently selected from -OH or YC(O)O-, Y is selected from -(CH=CH)m-phenyl or -(CH=CH)m-phenyl wherein the phenyl group is substituted by 1-5 R5, m is any natural number, and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl or -C1-C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I; preferably, Y is selected from (CH=CH)-phenyl.

4. Use according to claim 1, characterized in that, as an animal growth promoter, the organic acid metal compound and / or the solvate thereof is used as an animal feed additive or in the preparation of an animal feed additive.

5. Use according to claim 1, characterized in that, in the compound of Petition 870250085925, dated 09 / 23 / 2025, p. 47 / 157 3 / 6, the solvate of the organic acid metal compound is selected from one, more than one, or a combination of a hydrate, an acetone solvate, an ethanol solvate, a methanol solvate, a dimethyl sulfoxide solvate, an ethyl acetate solvate, an acetic acid solvate, and / or an isopropanol solvate of the organic acid metal compound;Preferably, the organic acid metal compound and / or its solvate is selected from one or more individual organic acid metal compounds having the same or different molecular formulas, one or more solvates of organic acid metal compounds having the same or different molecular formulas, or a combination of one or more organic acid metal compounds having the same or different molecular formulas and one or more solvates of organic acid metal compounds having the same or different molecular formulas; and more preferably, the organic acid metal compound includes an organic acid metal compound monomer or an organic acid metal compound polymer.

6. Composition, characterized by comprising an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne and / or a solvate thereof: wherein n is any natural number from 1-10; R1 is selected from YC(O)O- or a vegetable polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- and a vegetable polyphenol; preferably, R1 is selected from YC(O)O- or tannic acid, and each of R2 and R3 is independently selected from -OH, YC(O)O- or tannic acid;Y is selected from H, linear or branched C1-C19 alkyl or linear or branched C1-C19 alkyl substituted by 1-5 R4, C3-C7 cycloalkyl or C3-C7 cycloalkyl substituted by 1-5 R4, C3-C7 cycloheteroalkyl or C3-C7 cycloheteroalkyl substituted by 1-5 R4, C5-C12 aryl or C5-C12 aryl substituted by 1-5 R5, C5-C12 heteroaryl or C5-C12 heteroaryl substituted by 1-5 R5, -(CH=CH)m-(C5-C12 aryl) or -(CH=CH)m-(C5-C12 aryl) where C5-C12 aryl is substituted by 1-5 R5, -(CH=CH)m-(C5-C12 heteroaryl) or -(CH=CH)m-(C5-C12 heteroaryl) where C5-C12 heteroaryl is substituted by 1-5 R5; m is any natural number; Petition 870250085925, dated 23 / 09 / 2025, p. 48 / 157 4 / 6 R4 is selected from -OH, -NH2, -CN, -SH or -Xi, wherein Xi is selected from F, Cl, Br or I; and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, C1-C5 alkyl or -C1-C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I.; 7. Composition according to claim 6, characterized by comprising one, more than one or a combination of organic acid metal compounds having a molecular formula of Aln(R1)n(OH)n(OH)n, or Aln(R1)n(R2)n(OH)n, or Aln(R1)n(R2)n(R3)ne / or solvates thereof; where n, each of R1, R2, R3, Y, m, R4, R5, Xi and X2 is as defined in claim 6.

8. Composition according to claim 6, characterized by comprising one, more than one or a combination of organic acid metal compounds having molecular formulas of Aln(Ri)n(OH)n(OH)n, Aln(R1)n(R1)n(OH)n, and Aln(R1)n(R1)n(R1)ne and / or solvates thereof; where n, each of R1, R2, R3, Y, m, R4, R5, Xi and X2 is as defined in claim 6.

9. Composition, according to any one of claims 6 to 8, characterized in that, in the organic acid metal compound and / or the solvate thereof, the solvate of the organic acid metal compound is selected from one, more than one, or a combination of a hydrate, an acetone solvate, an ethanol solvate, a methanol solvate, a dimethyl sulfoxide solvate, an ethyl acetate solvate, an acetic acid solvate, and / or an isopropanol solvate of the organic acid metal compound;Preferably, the organic acid metal compound and / or its solvate is selected from one or more individual organic acid metal compounds having the same or different molecular formulas, one or more solvates of organic acid metal compounds having the same or different molecular formulas, or a combination of one or more organic acid metal compounds having the same or different molecular formulas and one or more solvates of organic acid metal compounds having the same or different molecular formulas; and more preferably, the organic acid metal compound includes an organic acid metal compound monomer or an organic acid metal compound polymer. Petition 870250085925, dated 23 / 09 / 2025, p. 49 / 157 5 / 6; 10. Composition, according to any one of claims 6 to 9, characterized by further comprising an animal feed raw material, and an additional animal feed additive and / or an acceptable feed processing aid, wherein the additional animal feed additive is selected from at least one of a nutritional feed additive, a non-nutritional feed additive or a medicinal feed additive.

11. Use of the composition, as defined in any one of claims 6 to 10, characterized in that it is used as an animal feed additive or in the preparation of an animal feed additive, wherein, preferably, the animal feed additive is an animal growth promoter.

12. Method for improving the production performance of an animal, characterized by comprising administering to the animal an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof or a composition comprising an organic acid metal compound having a molecular formula of Aln(R1)n(R2)n(R3)ne / or a solvate thereof: wherein n is any natural number from 1-10; R1 is selected from YC(O)O- or a vegetable polyphenol, and each of R2 and R3 is independently selected from -OH, YC(O)O- and a vegetable polyphenol; preferably, R1 is selected from YC(O)O- or tannic acid, and each of R2 and R3 is independently selected from -OH, YC(O)O- or tannic acid;Y is selected from H, linear or branched C1-C19 alkyl or linear or branched C1-C19 alkyl substituted by 1-5 R4, C3-C7 cycloalkyl or C3-C7 cycloalkyl substituted by 1-5 R4, C3-C7 cycloheteroalkyl or C3-C7 cycloheteroalkyl substituted by 1-5 R4, C5-C12 aryl or C5-C12 aryl substituted by 1-5 R5, C5-C12 heteroaryl or C5-C12 heteroaryl substituted by 1-5 R5, -(CH=CH)m-(C5-C12 aryl) or -(CH=CH)m-(C5-C12 aryl) where C5-C12 aryl is substituted by 1-5 R5, -(CH=CH)m-(C5-C12 heteroaryl) or -(CH=CH)m-(C5-C12 heteroaryl) where C5-C12 heteroaryl is replaced by 1-5 R5; m is any natural number; R4 is selected from -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I;and R5 is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, C1-C5 alkyl or -C1-C5 X2-substituted alkyl, wherein X2 is selected from F, Cl, Br or I. Petition 870250085925, dated 09 / 23 / 2025, page 51 / 157;