Composition comprising an isolated or purified population of bacteria, pharmaceutical formulation, use of said composition and method of predicting a response to an immune checkpoint inhibitor

Description

COMPOSITION COMPRISING AN ISOLATED OR PURIFIED POPULATION OF BACTERIA, PHARMACEUTICAL FORMULATION, USE OF SAID COMPOSITION AND METHOD OF PREDICTING A RESPONSE TO AN IMMUNOLOGICAL CHECKPOINT INHIBITOR Divided from BR 11 2019 006041 3, deposited on 09 / 27 / 2017.

[0001] This application claims the benefit of U.S. Provisional Patent Applications Nos. 62 / 400,372, filed September 27, 2016; No. 62 / 508,885, filed May 19, 2017; and No. 62 / 557,566, filed September 12, 2017, each of which is incorporated into the present invention by reference in its entirety. BACKGROUND OF THE INVENTION 1. Field of the Invention

[0002] The present invention relates generally to the fields of microbiology, immunology and medicine. More particularly, it relates to the use of the microbiome to improve the effectiveness of immune checkpoint blockade therapy. 2. Description of the related technique

[0003] In the last decade, great advances have been made in the treatment of melanoma through the use of targeted therapy and immunotherapy. In particular, the use of immune checkpoint inhibitors has shown tremendous promise, leading to FDA approval of several agents that block immunomodulatory molecules on the surface of T lymphocytes (e.g., the anti-CTLA-4 antibody ipilimumab, and the anti-PD-1 antibodies nivolumab and pembrolizumab). Importantly, treatment with immune checkpoint blockade can result in long-lasting complete responses, although overall response rates are modest (i.e., 15% with CTLA-4 blockade and 30–40% with PD-1 blockade).

[0004] However, immune checkpoint inhibitors may be associated with substantial toxicity and Petition 870260080213, dated 10 / 08 / 2026, page 12 / 398 2 / 296 Only a subset of patients may benefit. Efforts are being made to better understand the variation in responses to immune checkpoint blockade; however, it is still unclear what is contributing to this enhanced response in these patients, and there is a critical need to identify actionable strategies to improve therapy responses in all patients.

[0005] There is a growing appreciation of the role of the host microbiome in cancer therapy responses, and studies suggest that bacteria present in the tumor and gut may impact therapeutic responses. There is also a growing appreciation of the role of the gastrointestinal microbiome in shaping immune responses in health and disease. However, there is a significant translational knowledge gap, and an unmet need for therapeutic strategies to improve responses to immune checkpoint blockade in melanoma and other cancer types. SUMMARY OF THE INVENTION

[0006] In one embodiment, the present disclosure provides a composition comprising at least one isolated or purified population of bacteria belonging to one or more families Ruminococcaceae, Clostridiaceae, Lachnospiraceae, Micrococcaceae and / or Veilonellaceae. In other embodiments, the composition comprises at least two isolated or purified populations of bacteria belonging to one or more families Ruminococcaceae, Clostridiaceae, Lachnospiraceae, Micrococcaceae and / or Veilonellaceae. In certain embodiments, the composition is a live bacterial product, a live biotherapeutic product or a probiotic composition. In still other embodiments, at least one isolated or purified bacterial population, or at least two isolated or purified bacterial populations, are provided as spores. Petition 870260080213, dated 10 / 08 / 2026, p. 13 / 398 3 / 296 bacteria. In another embodiment, at least one bacterial population belongs to the Clostridiales XII family and / or the Clostridiales XIII family. In some aspects, the composition comprises at least two isolated or purified bacterial populations belonging to the Ruminococcaceae family and / or the Clostridiaceae family. In other embodiments, the composition comprises at least one population belonging to the Ruminococcaceae family and at least one population belonging to the Clostridiaceae family. In some aspects, the two bacterial populations belonging to the Ruminococcaceae family are further defined as bacterial populations belonging to the genus Ruminococcus. In certain aspects, the at least two isolated or purified bacterial populations belonging to the Ruminococcaceae family are further defined as bacterial populations belonging to the genus Faecalibacterium.In certain aspects, the population of bacteria belonging to the genus Faecalibacterium is further defined as a population of bacteria belonging to the species Faecalibacterium prausnitzii. In certain aspects, the population of bacteria belonging to the genus Ruminococcus is further defined as a population of bacteria belonging to the species Ruminococcus bromii. In some aspects, the at least two isolated or purified bacterial populations belonging to the family Micrococcaceae are further defined as a population of bacteria belonging to the genus Rothia. In further aspects, the composition also comprises a population of bacteria belonging to the species Porphyromonas pasteri, the species Clostridium hungatei, the species Phascolarctobacterium faecium, the genus Peptoniphilus and / or the class Mollicutes. In certain aspects, the composition does not comprise populations of bacteria belonging to the order Bacteroidales.

[0007] Particular modalities of the present disclosure Petition 870260080213, dated 10 / 08 / 2026, p. 14 / 398 4 / 296 provide a method of preventing cancer in an individual comprising administering a composition of the embodiments to the individual. For example, in some aspects, a method is provided for preventing cancer in an individual at risk of developing cancer (e.g., melanoma) or treating cancer in an individual with a tumor comprising administering to the individual a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or the genus Faecalibacterium, wherein administration of the composition results in an increase in the number of CD8+ T lymphocytes in the tumor. In particular embodiments, the T lymphocytes are cytotoxic T lymphocytes.In other modalities, the method is a cancer treatment method in an individual that comprises administering a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or the genus Faecalibacterium, wherein the administration of the composition results in an increase in CD4+ T lymphocytes, effector CD8+ T lymphocytes, monocytes and / or myeloid dendritic cells in the systemic circulation or peripheral blood of the individual.In some embodiments, the method is a method of treating cancer in an individual that comprises administering a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or the genus Faecalibacterium and / or Ruminococcus, wherein administration of the composition results in a decrease in B cells, regulatory T cells and / or myeloid-derived suppressor cells in the systemic circulation or peripheral blood of the individual. In other aspects, the method is a method of... Petition 870260080213, dated 10 / 08 / 2026, page 15 / 398 5 / 296 treatment of cancer in an individual who has a tumor comprising administering a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or the genus Faecalibacterium, wherein the administration of the composition to the individual results in an increase in the expression of PD-L1 and / or granzyme B, CD3, CD8, PDI and FoxP3, in an immune infiltrate in the tumor. In still other aspects, the method is a method of treating cancer in an individual who has a tumor comprising administering a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or the genus Faecalibacterium, wherein the administration of the composition to the individual results in a decrease in the expression of RORyT in an immune infiltrate in the tumor.Methods of treating a tumor in an individual diagnosed with or suspected of having cancer are also described, comprising administering a composition comprising at least one isolated or purified bacterial population belonging to one or more of the class Clostridia, class Mollicutes, order Clostridiales, family Ruminococcaceae and / or genus Faecalibacterium, wherein administration of the composition to the individual results in an increase in CD45+, CD3+ / CD20+ / CD56+, CD68+ and / or HLA-DR+ cells in the tumor. In some respects, a composition of the modalities is administered in a sufficient quantity to increase the level of innate effector cells in the individual. In other respects, administration of the composition to the individual results in an increase in the level of innate effector cells in the individual. For example, administration of the composition may increase innate effector cells such as CD45+CD11b+Ly6G+ cells. Petition 870260080213, dated 10 / 08 / 2026, page 16 / 398 6 / 296 In some aspects, a composition of the modalities is administered in a sufficient quantity to decrease the level of myeloid suppressor cells in the individual. In further aspects, administration of the composition to the individual results in a decrease in the level of myeloid suppressor cells in the individual. For example, administration of the composition may decrease the level of myeloid suppressor cells, such as CD45+CD11b+CD11c+ cells. In particular modalities, the composition comprises the bacterium Faecalibacterium prausnitzii.

[0008] Another embodiment provides a method of treating cancer in an individual, comprising administering a therapeutically effective amount of an immune checkpoint inhibitor to said individual, wherein the individual has been determined to possess a favorable microbial profile in the gut microbiome. In some respects, a favorable microbial profile is further defined as having one or more of the bacterial populations of the probiotic compositions or live bacterial products of the embodiments. In a further embodiment, a method is provided for predicting a response (e.g., predicting survival) to an immune checkpoint inhibitor in a cancer patient, comprising detecting a microbial profile in a sample obtained from said patient, wherein, if the microbial profile comprises one or more of the bacterial populations of the probiotic or live bacterial product compositions of the embodiments, the response is favorable.In particular modalities, the patient is given an immune checkpoint inhibitor if it is anticipated that the patient will have a favorable response to the immune checkpoint inhibitor. In certain modalities, the favorable microbial profile is a favorable gut microbial profile.

[0009] In some modalities, at least one population Petition 870260080213, dated 10 / 08 / 2026, page 17 / 398 7 / 296 of isolated or purified bacteria, or at least two populations of isolated or purified bacteria, belong to one or more of the species, subspecies, or bacterial strains selected from the group consisting of the species in Table 1 with an enrichment index (ei) greater than 0.5, 0.6, 0.7, 0.8, or 0.9. In particular embodiments, at least one population of isolated or purified bacteria, or at least two populations of isolated or purified bacteria, are selected from the group consisting of the species in Table 1 with an enrichment index (ei) equal to 1.

[00010] In certain aspects, at least one isolated or purified bacterial population, or at least two isolated or purified bacterial populations, belong to the species, subspecies, or bacterial strains identified by the NCBI taxonomy IDs selected from the group consisting of NCBI taxonomy IDs 717959, 587, 758823, 649756, 44749, 671218, 1264, 1122135, 853, 484018, 46503, 54565, 290052, 216931, 575978, 433321, 1796646, 213810, 228924, 290054, 1509, 1462919, 29375, 337097, 1298596, 487174, 642492, 1735, 1297424, 742766, 46680, 132925, 411467, 1318465, 1852367, 1841857, 169679, 1175296, 259063, 172901, 39488, 57172, 28118, 166486, 28133, 1529, 694434, 1007096, 84030, 56774, 102148, 626947, 216933, 1348613, 1472417, 100176, 824, 1471761, 1297617, 288966, 1317125, 28197, 358743, 264639, 1265, 1335, 66219, 69473, 115117, 341220, 1732, 873513, 396504, 1796619, 45851, 2741, 105841, 86332, 1349822, 84037, 180311, 54291, 1217282, 762984, 1185412, 154046, 663278, 1543, 398512, 69825, 1841867, 1535, 1510, 84026, 1502, 1619234, 39497, 1544, 29343, 649762, 332095, 536633, 1033731, 574930, 742818, 177412, 1121308, 419208, 1673717, 55779, 28117, 626937, 180332, 1776382, 40519, 34062, 40518, 74426, 1216062, 293826, 850, 645466, 474960, 36835, 115544, 1515, 88431, 216932, 1417852, 39492, 1583, 420247, 118967, 169435, 37658, 138595, 31971, Petition 870260080213, dated 10 / 08 / 2026, p. 18 / 398 8 / 296 100886, 1197717, 234908, 537007, 319644, 168384, 915173, 95159, 1816678, 626940, 501571, 1796620, 888727, 1147123, 376806, 1274356, 1267, 39495, 404403, 1348, 253314, 258515, 33033, 1118061, 357276, 214851, 320502, 217731, 246787, 29371, 649764, 901, 29374, 33043, 39778, 682400, 871665, 160404, 745368, 408, 1584, 333367, 47246, 1096246, 53342, 438033, 351091, 1796622, 1776384, 817, 48256, 720554, 500632, 36849, 301302, 879970, 655811, 264463, 1532, 285, 995, 242750, 29539, 1432052, 622312, 1796636, 1337051, 328814, 28446, 1492, 820, 39496, 52786, 1549, 1796618, 582, 46507, 109327, 1531, 1382, 33039, 311460, 230143, 216935, 539, 35519, 1681, 328813, 214853, 89014, 1121115, 1585974, 29466, 1363, 292800, 270498, 214856, 142877, 133926, 209880, 179628, 1121102, 105612, 1796615, 39777, 29353, 1579, 163665, 53443, 261299, 1302, 1150298, 938289, 358742, 471875, 938278, 1796613, 1118057, 1077144, 1737, 218205, 1121298, 684066, 433659, 52699, 204516, 706562, 253257, 328812, 1280, 147802, 58134, 1335613, 891, 585394, 1582, 235931, 308994, 1589, 1682, 1736, 28129, 178001, 551788, 2051, 856, 118562, 101070, 515619, 40215, 187979, 82979, 29363, 1776391, 1285191, 84112, 157688, 38304, 36850, 341694, 287, 75612, 818, 371674, 338188, 88164, 588581, 676965, 546271, 1236512, 178338, 862517, 157687, 158, 51048, 1583331, 529, 888745, 394340, 40545, 855, 553973, 938293, 93063, 708634, 179995, 1351, 476652, 1464038, 555088, 237576, 879566, 1852371, 742727, 1377, 35830, 997353, 218538, 83771, 1605, 28111, 131109, 46609, 690567, 46206, 155615, 51616, 40542, 203, 294, 1034346, 156456, 80866, 554406, 796942, 1002367, 29347, 796944, 61592, 487175, 1050201, 762948, 137732, 1211819, 1019, 272548, 1717, 384636, 216940, 2087, 45634, 466107, 1689, 47678, 575, 979627, 840, 1660, 1236517, 617123, 546, 28135, 82171, 483, 501496, 99656, 1379, 84032, 39483, 1107316, 584, 28124, 1033744, 657309, 536441, 76123, 1118060, 89152, 76122, 303, 1541, 507751, 515620, 38302, Petition 870260080213, dated 10 / 08 / 2026, p. 19 / 398 9 / 296 53419, 726, 40324, 1796610, 988946, 1852370, 1017, 1168289, 76936, 94869, 1161098, 215580, 1125779, 327575, 549, 1450648 and 478. In specific aspects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations are closely related to the species, subspecies or bacterial strains identified by the NCBI taxonomy IDs listed above. For example, in some respects, at least one isolated or purified population of bacteria or at least two isolated or purified populations of bacteria belonging to the species, subspecies, or strains comprises a 16S ribosomal rRNA (rRNA) nucleotide sequence that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the 16S rRNA nucleotide sequence of one of the bacteria listed above (i.e., set 1 of bacteria from Table 1) or the bacteria listed in Table 1, and with an ei greater than 0.5 or equal to 1.

[00011] In still other species, at least one isolated or purified bacterial population, or at least two isolated or purified bacterial populations, belong to the species, subspecies or bacterial strains selected from the group consisting of Bacteroides coagulans, Clostridium aldenense, Clostridium aldrichii, Clostridium alkalicellulosi, Clostridium amygdalinum, Clostridium asparagiforme, Clostridium cellulosi, Clostridium citroniae, Clostridium clariflavum DSM 19732, Clostridium clostridioforme, Clostridium colinum, Clostridium fimetarium, Clostridium hiranonis, Clostridium hungatei, Clostridium hylemonae DSM 15053, Clostridium indolis, Clostridium lactatifermentans, Clostridium leptum, Clostridium methylpentosum, Clostridium oroticum, Clostridium papyrosolvens DSM 2782, Clostridium populeti, Clostridium propionicum, Clostridium Petition 870260080213, dated 10 / 08 / 2026, page 20 / 398 10 / 296 saccharolyticum, Clostridium scindens, Clostridium sporosphaeroides, Clostridium stercorarium, Clostridium straminisolvens, Clostridium sufflavum, Clostridium termitidis, Clostridium thermosuccinogenes, Clostridium viride, Clostridium xylanolyticum, Desulfotomaculum guttoideum, Eubacterium rectale ATCC 33656, Eubacterium dolichum, Eubacterium eligens ATCC 27750, Eubacterium hallii, Eubacterium inflrmum, Eubacterium siraeum, Eubacterium tenue, Ruminococcus torques, Acetanaerobacterium elongatum, Acetatifactor muris, Acetivibrio cellulolyticus, Acetivibrio ethanolgignens, Acholeplasma brassicae 0502, Acholeplasma parvum, Acholeplasma vituli, Acinetobacter junii, Actinobacillus porcinus, Actinomyces bowdenii, Actinomyces dentalis, Actinomyces odontolyticus, Acutalibacter muris, Aerococcus viridans, Aeromicrobium fastidiosum, Alistipes flnegoldii, Alistipes obesi, Alistipes onderdonkii, Alistipes putredinis, Alistipes shahii, Alistipes shahii WAL 8301, Alistipes timonensis JC136,Alkalibacter saccharofermentans, Alkaliphilus metalliredigens QYMF, Allisonella histaminiformans, Allobaculum stercoricanis DSM 13633, Alloprevotella rava, Alloprevotella tannerae, Anaerobacterium chartisolvens, Anaerobiospirillum thomasii, Anaerobium acetethylicum, Anaerococcus octavius ​​NCTC 9810, Anaerococcus provenciensis, Anaerococcus vaginalis ATCC 51170, Anaerocolumna jejuensis, Anaerofllum agile, Anaerofustis stercorihominis, Anaeroglobus geminatus, Anaeromassilibacillus senegalensis, Anaeroplasma abactoclasticum, Anaerorhabdus furcosa, Anaerosporobacter mobilis, Anaerostipes butyraticus, Anaerostipes caccae, Anaerostipes hadrus, Anaerotruncus colihominis, Anaerovorax odorimutans, Anoxybacillus rupiensis, Aquabacterium limnoticum, Arcobacter butzleri, Arthrospira platensis, Asaccharobacter celatus, Atopobium parvulum, Bacteroides caccae, Bacteroides caecimuris, Bacteroides, Petition 870260080213, dated 10 / 08 / 2026, p. 21 / 398 11 / 296 cellulosilyticus, Bacteroides clarus YIT 12056, Bacteroides dorei, Bacteroides eggerthii, Bacteroides flnegoldii, Bacteroides fragilis, Bacteroides gallinarum, Bacteroides massiliensis, Bacteroides oleiciplenus YIT 12058, Bacteroides plebeius DSM 17135, Bacteroides rodentium JCM 16496, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides xylanisolvens XB1A, Bacteroides xylanolyticus, Barnesiella intestinihominis, Beduini massiliensis, Bifidobacterium bifldum, Bifidobacterium dentium, Bifidobacterium longum subsp. infantis, Blautia caecimuris, Blautia coccoides, Blautia faecis, Blautia glucerasea, Blautia hansenii DSM 20583, Blautia hydrogenotrophica, Blautia luti, Blautia luti DSM 14534, Blautia wexlerae DSM 19850, Budvicia aquatica, Butyricicoccus pullicaecorum, Butyricimonas paravirosa, Butyrivibrio crossotus, Caldicoprobacter oshimai, Caloramator coolhaasii, Caloramator proteoclasticus, Caloramator quimbayensis, Campylobacter gracilis, Campylobacter rectus,Campylobacter ureolyticus DSM 20703, Capnocytophaga gingivalis, Capnocytophaga leadbetteri, Capnocytophaga sputigena, Casaltella massiliensis, Catabacter hongkongensis, Catenibacterium mitsuokai, Christensenella minuta, Christensenella timonensis, Chryseobacterium taklimakanense, Citrobacter freundii, Cloacibacillus porcorum, Clostridioides difflcile ATCC 9689 = DSM 1296, Clostridium amylolyticum, Clostridium bowmanii, Clostridium butyricum, Clostridium cadaveris, Clostridium colicanis, Clostridium gasigenes, Clostridium lentocellum DSM 5427, Clostridium oceanicum, Clostridium oryzae, Clostridium paraputriflcum, Clostridium pascui, Clostridium perfringens, Clostridium quinii, Clostridium saccharobutylicum, Clostridium sporogenes, Clostridium ventriculi, Collinsella aerofaciens, Comamonas testosteroni, Coprobacter fastidiosus NSB1, Coprococcus eutactus, Corynebacterium diphtheriae, Corynebacterium durum, Petition 870260080213, dated 10 / 08 / 2026, p. 22 / 398 12 / 296Corynebacterium mycetoides, Corynebacterium pyruviciproducens ATCC BAA-1742, Corynebacterium tuberculostearicum, Culturomica massiliensis, Cuneatibacter caecimuris, DeFluviitalea saccharophila, Delftia acidovorans, Desulftobacterium chlor ore spirans, Desulftobacterium metallireducens, Desulfosporosinus acididurans, Desulfotomaculum halophilum, De sulfo tomaculum intricatum, Desulfotomaculum tongense, Desulfovibrio desulfuricans subsp. desulfuricans, Desulfovibrio idahonensis, Desulfovibrio litoralis, Desulfovibrio piger, Desulfovibrio simplex, Desulfovibrio zosterae, Desulfuromonas acetoxidans, Dethiobacter alkaliphilus AHT 1, Dethiosulfatibacter aminovorans, Dialister invisus, Dialister propionificaciens, Dielma fastidiosa, Dietzia alimentaria 72, Dorea longicatena, Dysgonomonas gadei ATCC BAA-286, Dysgonomonas mossii, Eggerthella lenta, Eikenella corrodens, Eisenbergiella tayi, Emergencia timonensis, Enorma massiliensis phi, Enterococcus faecalis, Enterorhabdus muris,Ethanoligenens harbinense YUAN-3, Eubacterium coprostanoligenes, Eubacterium limosum, Eubacterium oxidoreducens, Eubacterium sulci ATCC 35585, Eubacterium uniforme, Eubacterium ventriosum, Eubacterium xylanophilum, Extibacterium muris, Ezakiella peruensis, Faecalibacterium prausnitzii, Faecalicoccus acidiformans, Faecalitalea cylindroides, Fllifactor villosus, Flavonifractor plautii, Flintibacter butyricus, Frisingicoccus caecimuris, Fucophilus fucoidanolyticus, Fusicatenibacter saccharivorans, Fusobacterium mortiferum, Fusobacterium nucleatum subsp. vincentii, Fusobacterium simiae, Fusobacterium varium, Garciella nitratireducens, Gemella haemolysans, Gemmiger formicilis, Gordonibacter urolithinfaciens, Gracilibacter thermotolerans TW / YJL-Sl, Granulicatella elegans, Guggenheimella bovis, Haemophilus haemolyticus, Helicobacter typhlonius, Hespellia stercorisuis, Holdemanella biformis, Petition 870260080213, dated 10 / 08 / 2026, p. 23 / 398 13 / 296 Holdemania massiliensis AP2, Howardella ureilytica, Hungatella efFluvii, Hungatella hathewayi, Hydrogenoanaerobacterium saccharovorans, Ihubacter massiliensis, Intestinibacter bartlettii, Intestinimonas butyriciproducens, Irregularibacter muris, Kiloniella laminariae DSM 19542, Kroppenstedtia guangzhouensis, Lachnoanaerobaculum orale, Lachnoanaerobaculum umeaense, Lachnoclostridium phytofermentans, Lactobacillus acidophilus, Lactobacillus algidus, Lactobacillus animalis, Lactobacillus casei, Lactobacillus delbrueckii, Lactobacillus fornicalis, Lactobacillus iners, Lactobacillus pentosus, Lactobacillus rogosae, Lactococcus garvieae, Lactonifactor longoviformis, Leptotrichia buccalis, Leptotrichia hofstadii, Leptotrichia hongkongensis, Leptotrichia wadei, Leuconostoc inhae, Levyella massiliensis, Loriellopsis cavernicola, Lutispora thermophila, Marinilabilia salmonicolor JCM 21150, Marvinbryantia formatexigens, Mesoplasma photuris, Methanobrevibacter smithii ATCC 35061,Methanomassiliicoccus luminyensis BIO, Methylobacterium extorquens, Mitsuokella jalaludinii, Mobilitalea sibirica, Mobiluncus curtisii, Mogibacterium pumilum, Mogibacterium timidum, Moorella glycerini, Moorella humiferrea, Moraxella nonliquefaciens, Moraxella osloensis, Morganella morganii, Moryella indoligenes, Muribaculum intestinale, Murimonas intestini, Natranaerovirga pectinivora, Neglecta timonensis, Neisseria cinerea, Neisseria oralis, Nocardioides mesophilus, Novibacillus thermophilus, Ochrobactrum anthropi, Odoribacter splanchnicus, Olsenella profusa, Olsenella uli, Oribacterium asaccharolyticum ACB7, Oribacterium sinus, Oscillibacter ruminantium GH1, Oscillibacter valericigenes, Oxobacter pfennigii, Pantoea agglomerans, Papillibacter cinnamivorans, Parabacteroides faecis, Parabacteroides goldsteinii, Parabacteroides gordonii, Parabacteroides merdae, Parasporobacterium paucivorans, Parasutterella, Petition 870260080213, dated 10 / 08 / 2026, p. 24 / 398 14 / 296 excrementihominis, Parasutterella secunda, Parvimonas micro, Peptococcus niger, Peptoniphilus duerdenii ATCC BAA-1640, Peptoniphilus grossensis ph5, Peptoniphilus koenoeneniae, Peptoniphilus senegalensis JC140, Peptostreptococcus stomatis, Phascolarctobacterium succinatutens, Phocea massiliensis, Pontibacter indicus, Porphyromonas bennonis, Porphyromonas endodontalis, Porphyromonas pasteri, Prevotella bergensis, Prevotella buccae ATCC 33574, Prevotella denticola, Prevotella enoeca, Prevotella fusca JCM 17724, Prevotella loescheii, Prevotella nigrescens, Prevotella oris, Prevotella pallens ATCC 700821, Prevotella stercorea DSM 18206, Prevotellamassilia timonensis, Propionispira arcuata, Proteus mirabilis, Providencia rettgeri, Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933, Pseudobutyrivibrio ruminis, PseudoFlavonifractor capillosus ATCC 29799, Pseudomonas aeruginosa, Pseudomonas Fluorescens, Pseudomonas mandelii, Pseudomonas nitroreducens, Pseudomonas putida,Raoultella ornithinolytica, Raoultella planticola, Raoultibacter massiliensis, Robinsoniella peoriensis, Romboutsia timonensis, Roseburia faecis, Roseburia hominis A2183, Roseburia intestinalis, Roseburia inulinivorans DSM 16841, Rothia dentocariosa ATCC 17931, Ruminiclostridium thermocellum, Ruminococcus albus, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus champanellensis 18P13 = JCM 17042, Ruminococcus faecis JCM 15917, Ruminococcus Flavefaciens, Ruminococcus gauvreauii, Ruminococcus lactaris ATCC 29176, Rummeliibacillus pycnus, Saccharofermentans acetigenes, Scardovia wiggsiae, Schlegelella thermodepolymerans, Sedimentibacter hongkongensis, Selenomonas sputigena ATCC 35185, Slackia exigua ATCC 700122, Slackia piriformis YIT 12062, Solitalea canadensis, Solobacterium moorei, Sphingomonas aquatilis, Spiroplasma alleghenense, Spiroplasma chinense, Spiroplasma chrysopicola, Spiroplasma, Petition 870260080213, dated 10 / 08 / 2026, p. 25 / 398 15 / 296 culicicola, Spiroplasma lampyridicola, Sporobacter termitidis, Staphylococcus aureus, Stenotrophomonas maltophilia, Stomatobaculum longum, Streptococcus agalactiae ATCC 13813, Streptococcus cristatus, Streptococcus equinus, Streptococcus gordonii, Streptococcus lactarius, Streptococcus parauberis, Subdoligranulum variabile, Succinivibrio dextrinosolvens, Sutterella stercoricanis, Sutterella wadsworthensis, Syntrophococcus sucromutans, Syntrophomonas zehnderi OL-4, Terrisporobacter mayombei, Thermoleophilum album, Treponema denticola, Treponema socranskii, Tyzzerella nexilis DSM 1787, Vallitalea guaymasensis, Vallitalea pronyensis, Vampirovibrio chlorellavorus, Veillonella atypica, Veillonella denticariosi, Veillonella dispar, Veillonella parvula, Victivallis vadensis, Vulcanibacillus modesticaldus and Weissella confusa.

[00012] In certain aspects, at least one isolated or purified bacterial population or at least two isolated or purified populations belong to the selected bacterial species from the species in Table 2 designated with a responder (R) response state. In further aspects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations belong to species, subspecies, or strains comprising a 16S ribosomal rRNA (rRNA) nucleotide sequence that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the 16S rRNA nucleotide sequence of bacteria selected from the species in Table 2 designated with a responder (R) response state.In particular aspects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations comprise a nucleotide sequence of 16S ribosomal RNA (rRNA) that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%,. Petition 870260080213, dated 10 / 08 / 2026, p. 26 / 398 16 / 296 95%, 96%, 97%, 98%, 99% or 100% identical to the 16S rRNA nucleotide sequence of selected bacteria from the group consisting of the species in Table 2 designated with a responder (R) response state and having an unadjusted p-value less than 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02 or 0.01.

[00013] In certain respects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations comprise a 16S ribosomal RNA (rRNA) nucleotide sequence that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to the 16S rRNA nucleotide sequence of selected bacteria from the group consisting of the species in Table 1 designated with a responder (R) response state and having an unadjusted p-value less than 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02 or 0.01.In particular embodiments, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations is a bacterial species, subspecies or strain comprising a 16S rRNA gene sequence that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to the SEQ ID sequence NOS: 1 to 876.

[00014] In some respects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations belong to the selected bacterial species from the species in Table 2 designated with a responder (R) response status. In particular respects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations belong to the selected bacterial species from the group consisting of the species in Table 2 designated with a responder (R) response status and with Petition 870260080213, dated 10 / 08 / 2026, page 27 / 398 17 / 296 an unadjusted p-value less than 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02, or 0.01. In still other aspects, at least one isolated or purified bacterial population or at least two isolated or purified bacterial populations belonging to the species, subspecies or strains comprising nucleotide sequences with at least 60%, 65%, 70%, 75%, 80%, 90%, 95%, 96%, 97%, 98%, 99% or 100% percent identity with the sequences of the coabundant gene group (CAG) (see Table 2A) selected from the group consisting of SEQ ID NOs: 877-926, SEQ ID NOs: 927-976, SEQ ID NOs: 977-1026, SEQ ID NOs: 1027-1076, SEQ ID NOs: 1077-1126, SEQ ID NOs: 1127-1176, SEQ ID NOs: 1177-1226, SEQ ID NOs: 1227-1276, SEQ ID NOs: 1277-1326, SEQ ID NOs: 1327-1376, SEQ ID NOs: 1377-1426, SEQ ID NOs: 1427-1476, SEQ ID NOs: 1477-1526, SEQ ID NOs: 1527-1576, SEQ ID NOs: 1577-1626, SEQ ID NOs: 1627-1676, SEQ ID NOs: 1677-1726, SEQ ID NOs: 17271776, SEQ ID NOs: 1777-1826,SEQ ID NOs: 1827-1876, SEQ ID NOs: 1877-1926, SEQ ID NOs: 1927-1976, SEQ ID NOs: 1977-2026, SEQ ID NOs: 2027-2076, SEQ ID NOs: 2077-2126, SEQ ID NOs: 2127-2176, SEQ ID NOs: 2177-2226, SEQ ID NOs: 2227-2276, SEQ ID NOs: 2277-2326, SEQ ID NOs: 2327-2376, SEQ ID NOs: 23772426, SEQ ID NOs: 2427-2476, SEQ ID NOs: 2477-2526, SEQ ID NOs: 2527-2576, SEQ ID NOs: 2577-2626 and SEQ ID NOs: 2627-2676. ID CAG Sequence Identifiers CAG00327 SEQ ID Nos: 877-926 CAG00659 SEQ ID Nos: 927-976 CAG00492 SEQ ID Nos: 977-1026 CAG00518 SEQ ID Nos: 1027-1076 CAG01146 SEQ ID Nos: 1077-1126 CAG00079 SEQ ID Nos: 1127-1176 CAG00393 SEQ ID Nos: 1177-1226 CAG00766 SEQ ID Nos: 1227-1276 Petition 870260080213, dated 10 / 08 / 2026, page 28 / 398 18 / 296 CAG00095 SEQ ID NOs: 1277-1326 CAG00010_1 SEQ ID NOs: 1327-1376 CAG00342 SEQ ID NOs: 1377-1426 CAG00303 SEQ ID NOs: 1427-1476 CAG00337 SEQ ID NOs: 1477-1526 CAG00381 SEQ ID NOs: 1527-1576 CAG00559 SEQ ID NOs: 1577-1626 CAG00570 SEQ ID NOs: 1627-1676 CAG00635 SEQ ID NOs: 1677-1726 CAG00636 SEQ ID NOs: 1727-1776 CAG00660 SEQ ID NOS: 1777-1826 CAG00669 SEQ ID NOs: 1827-1876 CAG00708 SEQ ID NOs: 1877-1926 CAG00773 SEQ ID NOs: 1927-1976 CAG00807 SEQ ID NOs: 1977-2026 CAG00880 SEQ ID NOs: 2027-2076 CAG00907 SEQ ID NOs: 2077-2126 CAG01086 SEQ ID NOs: 2127-2176 CAG01215 SEQ ID NOs: 2177-2226 CAG01277 SEQ ID NOs: 2227-2276 CAG01308 SEQ ID NOs: 2277-2326 CAG00577 SEQ ID NOs: 2327-2376 CAG00506 SEQ ID NOs: 2377-2426 CAG00852 SEQ ID NOs: 2427-2476 CAG01046 SEQ ID NOs: 2477-2526 CAG00320 SEQ ID NOs: 2527-2576 CAG00619 SEQ ID NOs: 2577-2626 CAG01366 SEQ ID NOs: 2627-2676

[00015] In certain aspects, at least one population of Petition 870260080213, dated 10 / 08 / 2026, page 29 / 398 19 / 296 isolated or purified bacteria, or the two populations of isolated or purified bacteria are selected from the group consisting of the species, subspecies, or strains comprising nucleotide sequences with at least 29% identity to SEQ ID NOs: 877-926, at least 16.5% identity to SEQ ID NOs: 927-976, at least 48.5% identity to SEQ ID NOs: 977-1026, at least 28% identity to SEQ ID NOs: 1027-1076, at least 93.5% identity to SEQ ID Nos: 1077-1126, at least 99.5% match with the SEQs ID Nos: 1127-1176, at least 99.5% match with the SEQs ID Nos: 1177-1226, at least 99% match with the SEQ IDs Nos: 1227-1276, 100% identity with the SEQ IDs Nos: 12771326, at least 21.5% identity with the SEQ IDs Nos: 13271376, 100% identity with the SEQ IDs Nos: 1377-1426, at least 97% identity with the SEQ IDs Nos: 1427-1476, at least 55.5% identity with the SEQ IDs Nos: 1477-1526, 100% identity with the SEQ IDs Nos: 1527-1576, at least 34% identity with the SEQ IDs Nos: 1577-1626, at least 14% identity with the SEQ IDs Nos: 1627-1676, 100% identity with the SEQ IDs Nos: 1677-1726, at least 93% match with SEQ ID Nos: 1727-1776, 100% match with SEQ IDs Nos: 1777-1826, at least 45% identity with the SEQID Nos: 1827-1876, at least 99% identity with the SEQID Nos: 1877-1926, at least 74% identity with the SEQID Nos: 1927-1976, 100% identity with SEQ ID Nos: 1977-2026, 100% identity with SEQ ID Nos: 2027-2076, at least 20% identity with SEQ ID Nos: 2077-2126, at least 84% identity with SEQ ID Nos: 2127-2176, at least 35.5% identity with SEQ ID Nos: 2177-2226, at least 32.5% identity with SEQ ID Nos: 2227-2276, at least 70% identity with SEQ ID Nos: 2277-2326, 100% identity with SEQ ID Nos: 2327-2376, at least 70.5% identity with SEQ ID Nos: 2377- 2426, at least 99.5% of Petition 870260080213, dated 10 / 08 / 2026, p. 30 / 398 20 / 296 identity with SEQ IDs NOS: 2427-2476, at least 68.5% identity with SEQ IDs NOS: 2477-2526, 100% identity with SEQ IDs NOS: 2527-2576, at least 97.5% identity with SEQ IDs NOS: 2577-2626, or 100% identity with SEQ IDs NOS: 2627-2676.

[00016] In certain aspects, at least one isolated or purified bacterial population or both bacterial populations are selected from the group consisting of species, subspecies or strains comprising nucleotide sequences with at least 29% identity with Faecalibacterium sp. CAG: 74 genes corresponding to SEQ ID Nos: 877-926, at least 16.5% identity with Clostridiales NK3B98 bacteria genes corresponding to SEQ ID Nos: 927-976, at least 48.5% identity with Subdoligranulum sp. 4_3_54A2FAA genes corresponding to SEQ ID Nos: 977-1026, at least 28% identity with Faecalibacterium sp. genes. CAG: 74 corresponding to genes corresponding to SEQ ID NOs: 1027-1076, at least 93.5% identity with Oscillibacter sp. CAG: 155 corresponding to SEQ ID NOs: 1077-1126, at least 99.5% identity with Clostridium sp.CAG: 7 corresponding to SEQ ID NO: 11271176, at least 99.5% identity with Eubacterium sp. CAG: 8 6 corresponding to SEQ ID NOs: 1177-1226, at least 99% identity with the genes of the bacterium Firmicutes CAG: 176 corresponding to SEQ ID NOs: 1227-1276, 100% identity with the genes of Akkermansia sp. CAG: 344 corresponding to SEQ ID NOs: 1277-1326, at least 21.5% identity with Faecalibacterium sp. CAG: 74 corresponding to SEQ ID NOs: 1327-1376, 100% identity with the genes of Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 corresponding to SEQ ID NOs: 1377-1426, at least 97% identity with the genes of Clostridium sp. JCC corresponding to SEQ ID NOs: 1427-1476. Petition 870260080213, dated 10 / 08 / 2026, p. 31 / 398 21 / 296 at least 55.5% identity with genes of Faecalibacterium prausnitzii SL3 / 3 corresponding to SEQ ID NOs: 1477-1526, 100% identity with genes of Clostridium sp. CAG: 242 corresponding to SEQ ID NOs: 1527-1576, at least 34% identity with Clostridium sp. CAG: 226 corresponding to SEQ ID NOs: 1577-1626, at least 14% identity with Ruminococcus sp. CAG: 382 which correspond to SEQ ID NOs: 1627-1676, 100% identity with the genes of Bifidobacterium bifidum S17 which correspond to SEQ ID NOs: 1677-1726, at least 93% identity with the genes of Roseburia sp.CAG: 309 corresponding to SEQ ID NOs: 1727-1776, 100% identity with genes of Alistipes timonensis; JC136 corresponding to SEQ ID NOs: 1777-1826, at least 45% identity with genes of the bacterium Firmicutes; CAG: 103 corresponding to SEQ ID NOs: 1827-1876, at least 99% identity with genes of Alistipes senegalensis; JC50 corresponding to SEQ ID NOs: 1877-1926, at least 74% identity with genes of the bacterium Firmicutes; CAG: 176 corresponding to SEQ ID NOs: 1927-1976, 100% identity with genes of Holdemanella biformis; DSM 3989 corresponding to SEQ ID NOs: 1977-2026, 100% identity with Subdoligranulum sp. CAG: 314 which correspond to SEQ ID NOs: 2027-2076, at least 20% identity with Clostridium sp.CAG: 226 corresponding to SEQ ID NOs: 2077-2126, at least 84% identity with the genes of the bacterium Firmicutes; CAG: 124 corresponding to SEQ ID NOs: 2127-2176, at least 35.5% identity with the genes of Intestinimonas butyriciproducens corresponding to SEQ ID NOs: 2177-2226, at least 32.5% identity with Clostridium sp.; CAG: 226 corresponding to SEQ ID NOs: 2227-2276, at least 70% identity with the genes of the bacterium Firmicutes; CAG: 124 corresponding to SEQ ID NOs: 2277-2326, 100% identity with... Petition 870260080213, dated 10 / 08 / 2026, p. 32 / 398 22 / 296 the genes of Faecalibacterium prausnitzii L2-6 corresponding to SEQ ID NOs: 2327-2376, at least 70.5% identity with the genes of the bacterium Ruminococcaceae D16 corresponding to SEQ ID NOs: 2377-2426, at least 99.5% identity with the genes of Clostridium spiroforme DSM 1552 corresponding to SEQ ID NOs: 2427-2476, at least 68.5% identity with the genes of Intestinimonas butyriciproducens corresponding to SEQ ID NOs: 2477-2526, 100% identity with the genes of Phascolarctobacterium sp. CAG: 207 corresponding to SEQ ID NOs: 2527-2576, at least 97.5% identity with Faecalibacterium prausnitzii L2-6 genes corresponding to SEQ ID NOs: 2577-2626 or 100% identity with Streptococcus parasanguinis ATCC 15912 genes corresponding to SEQ ID NOs: 2627-2676.

[00017] In some respects, the bacteria are lyophilized or freeze-dried. In particular respects, the composition is formulated for oral administration. For example, the composition formulated for oral administration is a tablet or capsule. In particular respects, the tablet or capsule comprises an acid-resistant enteric coating. In certain respects, the composition comprising at least one isolated or purified population of bacteria, or at least two isolated or purified populations of bacteria, is formulated for administration by rectal route, colonoscopy, sigmoidoscopy, nasogastric tube or enema. In some respects, the composition is lyophilized or frozen. In certain respects, the composition is capable of being reformulated for final release as comprising a liquid, a suspension, a gel, a gelatin capsule (geltab), a semisolid, a tablet, a sachet, a lozenge, a capsule or as an enteral formulation.In some respects, the composition is formulated for multiple administrations. In some respects, it targets at least one population of bacteria. Petition 870260080213, dated 10 / 08 / 2026, page 33 / 398 23 / 296 isolated or purified bacteria, or at least two isolated or purified bacterial populations, comprise an antibiotic resistance gene. In some respects, at least one isolated or purified bacterial population, or at least two isolated or purified bacterial populations, are a population of short-chain fatty acid-producing bacteria. In certain respects, the population of short-chain fatty acid-producing bacteria is a population of butyrate-producing bacteria. In particular aspects, at least one immune checkpoint inhibitor is administered intravenously and the population of butyrate-producing bacteria is administered orally.

[00018] The embodiments of the present disclosure provide a method of treating cancer in an individual comprising administering a therapeutically effective amount of a short-chain fatty acid, such as butyrate, and / or a population of short-chain fatty acid-producing bacteria to said individual, wherein the individual has received an immune checkpoint inhibitor. In some aspects, the method further comprises administering at least one immune checkpoint inhibitor. In certain aspects, more than one checkpoint inhibitor is administered. In some aspects, the method further comprises administering a prebiotic or probiotic.

[00019] In some respects, the population of short-chain fatty acid-producing bacteria comprises bacteria containing an antibiotic resistance gene. In some respects, the butyrate-producing bacterial population comprises bacteria containing an antibiotic resistance gene. In some embodiments, the mode further comprises a step of administering such a population of antibiotic-resistant short-chain fatty acid-producing bacteria, for example, to such a bacterial population resistant to Petition 870260080213, dated 10 / 08 / 2026, page 34 / 398 24 / 296 butyrate-producing antibiotic, to an individual with cancer. In some embodiments, the method further involves administering the antibiotic to which the population of antibiotic-resistant bacteria producing short-chain fatty acids, such as the antibiotic-resistant butyrate-producing bacterial population, are resistant to the individual, where the antibiotic resistance gene confers resistance to the antibiotic.

[00020] In some respects, the butyrate-producing bacterial population comprises one or more bacterial species of the order Clostridiales. In certain respects, one or more bacterial species are of the family Ruminococcaceae, Christensenellaceae, Clostridiaceae, or Coriobacteriaceae.In particular aspects, the one or more bacterial species are selected from the group consisting of Faecalibacterium prausnitzii, Ruminococcus albus, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus flavefaciens, Ruminococcus champanellensis, Ruminococcus faecis, Ruminococcus gauvreauii, Ruminococcus gnavus, Ruminococcus hansenii, Ruminococcus hydro genotrophicus, Ruminococcus lactaris, Ruminococcus luti, Ruminococcus obeum, Ruminococcus palustris, Ruminococcus pasteurii, Ruminococcus productus, Ruminococcus schinkii, Ruminococcus torques, Subdoligranulum variabile, Butyrivibrio fibrisolvens, Roseburia intestinalis, Anaerostipes caccae, Blautia obeum, Eubacterium nodatum and Eubacterium oxidoreducens. In a specific aspect, the one or more bacterial species is Faecalibacterium prausnitzii. Em aspectos particulares, a populazione bacteriala producora de butirato não comprehende especia bacterianas da família Prevotellaceae ou da ordem Bacteriodales.

[00021] In certain respects, butyrate administration comprises the administration of a prodrug or butyrate salt. In particular respects, butyrate administration comprises the administration of sodium butyrate, Petition 870260080213, dated 10 / 08 / 2026, page 35 / 398 25 / 296 arginine butyrate, ethylbutyryl lactate, tributyrin, 4-phenyl butyrate, pivaloyloxymethyl butyrate (AN-9) or butylidene dibutyrate (AN-10).

[00022] In some aspects, butyrate or the butyrate-producing bacterial population is administered orally, rectally, colonoscopically, sigmoidoscopically, by enema, or by direct injection. In particular aspects, at least one immune checkpoint inhibitor is administered intravenously, and butyrate and / or the butyrate-producing bacterial population is administered orally.

[00023] In some respects, at least one checkpoint inhibitor is selected from an inhibitor of CTLA-4, PD-1, PD-L1, PD-L2, LAG-3, BTLA, B7H3, B7H4, TIM3, KIR, or A2aR. In some respects, at least one checkpoint inhibitor is a programmed cell death axis 1 (PD-1) binding antagonist. In some respects, the PD-1 axis binding antagonist is selected from the group consisting of a PD-1 binding antagonist, a PD1 binding antagonist, and a PD2 binding antagonist. In some respects, the PD-1 axis binding antagonist is a PD-1 binding antagonist. In some respects, the PD-1 binding antagonist inhibits PD-1 binding to PD1 and / or PD-L2. In specific aspects, the PD-1 binding antagonist is either a monoclonal antibody or an antigen-binding fragment of the same.In specific aspects, the PD-1 binding antagonist is nivolumab, pembrolizumab, pidilizumab, KEYTRUDA®, AMP-514, REGN2810, CT-011, BMS 936559, MPDL3280A, or AMP-224. In some aspects, at least one immune checkpoint inhibitor is an anti-CTLA-4 antibody. In particular aspects, the anti-CTLA-4 antibody is tremelimumab, YERVOY®, or ipilimumab. In certain aspects, at least one immune checkpoint inhibitor is an anti-killer cell receptor antibody. Petition 870260080213, dated 10 / 08 / 2026, page 36 / 398 26 / 296 similar to immunoglobulin (KIR). In some respects, the anti-KIR antibody is lirilumab.

[00024] In certain aspects, the cancer is a skin cancer, such as basal cell skin cancer, squamous cell skin cancer, or melanoma. In other aspects, the skin cancer is a selected skin cancer from the group consisting of dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and angiosarcoma. In particular aspects, the melanoma is metastatic melanoma. In other aspects, the melanoma is lentigo maligna, lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, or desmoplastic melanoma.

[00025] In certain respects, the method further comprises administering at least one additional anticancer treatment. In some respects, the at least one additional anticancer treatment is surgical therapy, chemotherapy, radiotherapy, hormone therapy, immunotherapy, small molecule therapy, kinase receptor inhibitor therapy, antiangiogenic therapy, cytokine therapy, cryotherapy, or a biological therapy. In some respects, the biological therapy is monoclonal antibody therapy, siRNA, miRNA, antisense oligonucleotide, ribozyme, or gene therapy.

[00026] In some respects, at least one immune checkpoint inhibitor and / or at least one additional anticancer treatment is administered intratumorally, intraarterially, intravenously, intravascularly, intrapleurally, intraperitoneally, intratracheally, intrathecally, intramuscularly, endoscopically, intralesionally, percutaneously, subcutaneously, Petition 870260080213, dated 10 / 08 / 2026, page 37 / 398 27 / 296 regionally, stereotaxically, orally, or by direct injection or infusion. In particular aspects, at least one immune checkpoint inhibitor is administered intravenously, and butyrate and / or the butyrate-producing bacterial population is administered orally.

[00027] Another modality provides a method of treating cancer in an individual, which comprises administering a therapeutically effective amount of an immune checkpoint inhibitor to said individual, where the individual has been determined to have a favorable microbial profile in the gut microbiome.In some respects, a favorable microbial profile is further defined as having: (a) high alpha diversity of the gut microbiome; (b) a high abundance of short-chain fatty acid-producing bacteria, such as butyrate-producing bacteria, in the gut microbiome; (c) one or more (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10 or more) bacteria selected from the group consisting of the species in Table 1 with an enrichment index (ei) greater than 0.5, 0.6, 0.7, 0.8 or 0.9 or equal to 1 in the gut microbiome; (d) one or more (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10 or more) of the bacterial species in Table 2 designated with a responder (R) response status in the gut microbiome; and / or (e) clusters centered around the R-centroid by beta diversity (e.g., weighted UniFrac distances).

[00028] In some respects, a favorable microbial profile is further defined as the presence of high abundance of bacteria from the phylum Firmicutes, class Clostridia, order Clostridiales, family Ruminococcaceae, genus Ruminococcus, genus Faecalibacterium, genus Hydrogenoanaerobacterium, of the phylum Actinobacteria, of the class Coriobacteriia, of the order Coriobacteriales, of the family Coriobacteriaceae, from the domain Archaea, of the phylum Cyanobacteria, Petition 870260080213, dated 10 / 08 / 2026, p. 38 / 398 28 / 296 of the phylum Euryarchaeota or the family Christensenellaceae. In certain aspects, a favorable microbial profile is further defined as the absence or low abundance of bacteria of the species Escherichia coli, the species Anerotruncus colihominis, the genus Dialister, the family Veillonellaceae, the phylum Bacteroidetes, the class Bacteroidia, the order Bacteroidales, or the family Prevotellaceae. In particular aspects, favorable microbial profiles are defined as the presence or high abundance of bacteria of the class Clostridiales and the absence or low abundance of bacteria of the order Bacteroidales. In some aspects, a favorable microbial profile is further defined as a high abundance of short-chain fatty acid-producing bacteria, such as butyrate-producing bacteria. In certain aspects, butyrate-producing bacteria comprise one or more species of the genus Ruminococcus or Faecalibacterium.

[00029] In some respects, the individual was determined to comprise a favorable microbial profile or favorable gut microbiome by analyzing the microbiome in a patient sample. In some respects, the patient sample is a fecal sample or an oral sample. In some respects, the analysis comprises performing 16S ribosomal sequencing and / or whole metagenomic genomic sequencing.

[00030] In a further embodiment, a method is provided for predicting a response (e.g., patient survival) to an immune checkpoint inhibitor in a cancer patient comprising detecting a microbial profile in a sample obtained from said patient, wherein, if the microbial profile comprises: (a) high alpha diversity; (b) a high abundance of short-chain fatty acid-producing bacteria, such as butyrate-producing bacteria; (c) one or more (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10 or more) bacteria selected from the group Petition 870260080213, dated 10 / 08 / 2026, page 39 / 398 29 / 296 consisting of the species in Table 1 with an enrichment index (ei) greater than 0.5, 0.6, 0.7, 0.8, or 0.9, or equal to 1; (d) one or more (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10 or more) of the bacterial species in Table 2 designated with a responder (R) response status; (e) a low abundance of Bacteriodales; and / or (f) distinct clusters by UniFrac weighted beta diversity distances, then the patient is predicted to have a favorable response to the immune checkpoint inhibitor. In particular embodiments, the patient is administered an immune checkpoint inhibitor if the patient is predicted to have a favorable response to the immune checkpoint inhibitor. In certain embodiments, a patient receives a second immune checkpoint inhibitor. In certain modalities, a favorable microbial profile is a favorable intestinal microbial profile.

[00031] In certain aspects, the cancer is a skin cancer, such as basal cell skin cancer, squamous cell skin cancer, or melanoma. In other aspects, the skin cancer is a selected skin cancer from the group consisting of dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and angiosarcoma. In other aspects, the melanoma is lentigo maligna, lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, or desmoplastic melanoma. In particular aspects, the immune checkpoint inhibitor is an anti-PD1 monoclonal antibody or an anti-CTLA4 monoclonal antibody.

[00032] In some respects, short-chain fatty acid-producing bacteria, such as the butyrate-producing bacterial population, comprise one or more species Petition 870260080213, dated 10 / 08 / 2026, page 40 / 398 30 / 296 bacteria of the order Clostridiales. In certain aspects, one or more species are from the family Ruminococcaceae, Christensenellaceae, Clostridiaceae or Coriobacteriaceae. In particular aspects, the one or more species are selected from the group consisting of Faecalibacterium prausnitzii, Ruminococcus albus, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus Flavefaciens, Ruminococcus champanellensis, Ruminococcus faecis, Ruminococcus gauvreauii, Ruminococcus gnavus, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus lactaris, Ruminococcus luti, Ruminococcus obeum, Ruminococcus palustris, Ruminococcus pasteurii, Ruminococcus productus, Ruminococcus schinkii, Ruminococcus torques, Subdoligranulum variabile, Butyrivibrio fibrisolvens, Roseburia intestinalis, Anaerostipes caccae, Blautia obeum, Eubacterium nodatum and Eubacterium oxidoreducens. Em certos aspectso, a uma ou mais species é Faecalibacterium prausnitzii.

[00033] In additional aspects, the method further comprises administering an immune checkpoint inhibitor to an individual who is predicted to have a favorable response to the immune checkpoint inhibitor. In some aspects, the immune checkpoint inhibitor is an anti-PD1 monoclonal antibody or an anti-CTLA4 monoclonal antibody.

[00034] In some respects, the method further comprises administering at least one additional anticancer treatment. In certain respects, the at least one additional anticancer treatment is surgical therapy, chemotherapy, radiotherapy, hormonal therapy, immunotherapy, small molecule therapy, kinase receptor inhibitor therapy, antiangiogenic therapy, cytokine therapy, cryotherapy, or a biological therapy. In particular respects, the at least one additional anticancer treatment Petition 870260080213, dated 10 / 08 / 2026, page 41 / 398 31 / 296 is a short-chain fatty acid, such as butyrate, and / or a population of bacteria that produce short-chain fatty acids, such as the butyrate-producing bacterial population. In specific aspects, at least one anticancer treatment is a combination of modalities. In some aspects, the method also includes administering a prebiotic or probiotic.

[00035] In another embodiment, a method is provided for predicting a response to an immune checkpoint inhibitor in a cancer patient, which comprises detecting a microbial profile in a sample obtained from said patient, wherein if the microbial profile comprises: (a) a low abundance of short-chain fatty acid-producing bacteria, such as butyrate-producing bacteria; (b) one or more of the bacterial species in Table 2 designated with a non-responder (NR) response state; (c) low alpha diversity; and / or (d) a high quantity of the order Bacteroidales, then the patient is expected not to have a favorable response to the immune checkpoint inhibitor. In other aspects, the method further comprises administering to the patient a probiotic or live bacterial composition of the embodiments if it is predicted that the patient will not have a favorable response to the immune checkpoint inhibitor.In yet another aspect, a patient who is not expected to have a favorable response to an immune checkpoint inhibitor is given an immune checkpoint inhibitor after administration of a prebiotic or live bacterial product composition of the modalities.

[00036] In additional aspects, the method further comprises administering at least one non-immune checkpoint inhibitor anticancer treatment to an individual who is predicted not to have a favorable response to the immune checkpoint inhibitor. Petition 870260080213, dated 10 / 08 / 2026, page 42 / 398 32 / 296

[00037] In additional aspects, the method comprises administering at least one anticancer treatment to an individual. In some aspects, the at least one anticancer treatment is surgical therapy, chemotherapy, radiotherapy, hormonal therapy, immunotherapy, small molecule therapy, kinase receptor inhibitor therapy, antiangiogenic therapy, cytokine therapy, cryotherapy, an immune checkpoint inhibitor, a second immune checkpoint inhibitor, or a biological therapy. In particular aspects, the at least one additional anticancer treatment is a short-chain fatty acid, such as butyrate, and / or a population of short-chain fatty acid-producing bacteria, such as the butyrate-producing bacterial population. In some aspects, the anticancer therapy is a prebiotic or probiotic. In specific aspects, the probiotic is a probiotic composition of the modalities.

[00038] In certain aspects, the cancer is a skin cancer, such as basal cell skin cancer, squamous cell skin cancer, or melanoma. In other aspects, the skin cancer is a selected skin cancer from the group consisting of dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and angiosarcoma. In other aspects, the melanoma is lentigo maligna, lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, or desmoplastic melanoma.

[00039] In some respects, if the microbial profile comprises one or more of the bacterial species in Table 2 designated with a non-responder (NR) response state or a high quantity of the order Bacteriodales, then it is Petition 870260080213, dated 10 / 08 / 2026, page 43 / 398 33 / 296 predicts that the patient will not have a favorable response to the immune checkpoint inhibitor. In some aspects, if the microbial profile comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more of the bacterial species in Table 2 designated with a non-responder (NR) response state, then it is predicted that the patient will not have a favorable response to the immune checkpoint inhibitor. In further aspects, the method comprises administering to the patient a composition of prebiotic product or live bacterial product of the embodiments.

[00040] Other objects, features and advantages of the present invention will become apparent from the detailed description that follows. It should be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various alterations and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[00041] The following drawings form part of this descriptive report and are included to further demonstrate certain aspects of the present invention. The invention can be better understood by reference to one or more of these drawings in combination with the detailed description of the specific embodiments presented in this application.

[00042] Figures 1A to G: Increased gut microbiome diversity is associated with enhanced responses to PD-1 blockade in patients with metastatic melanoma. (A) Sample collection and analysis scheme. (B) Stacked bar graph of the phylogenetic composition of common bacterial taxa (> 0.1% abundance) at the order level in oral (n = 109, top) and fecal (n = 53, bottom) samples by Petition 870260080213, dated 10 / 08 / 2026, page 44 / 398 34 / 296 16S rRNA sequencing. (C) Bipartite network diagram of matched oral and fecal samples from 48 patients treated with anti-PD-1. Edges connect species-level OTUs to the sample nodes where they are found. (D) Inverse Simpson diversity scores of the gut microbiome in R (n = 30) and NR (n = 13) for anti-PD-1 therapy by the Mann-Whitney (MW) test. (E) Phylogenetic composition of 39 fecal samples at the family level (> 0.1% abundance) at baseline. High (> 11.63, n = 13), intermediate (7.46 to 11.63, n = 13), and low (< 7.46, n = 13) diversity groups were determined using the tertiles of the inverse Simpson scores. (F) Kaplan-Meier (KM) plot of progression-free survival (PFS) by fecal diversity; high (median PFS undefined), intermediate (median PFS = 232 days) and low (median PFS = 188 days).High versus intermediate diversity (HR = 3.60; 95% CI = 1.02 to 12.74) and high versus low diversity (low HR = 3.57; 95% CI = 1.02 to 12.52) by the univariate Cox model. *p < 0.05, **p < 0.01. (G) Principal coordinate analysis of fecal samples (n = 43) by response using weighted UniFrac distances.

[00043] Figures 2A to F: Differences in gut microbiome composition are associated with responses to PD-1 blockade. (A) Heat map of OTU abundances in R (n = 30) and NR (n = 13). Columns denote patients and rows denote bacterial species grouped according to their enrichment in R versus NR in 3 sets. (B) Phylogenetic composition of OTUs within each set at the order level. (C) Taxonomic cladogram of LEfSe showing differences in fecal taxa. Point size is proportional to taxon abundance. (D) LDA scores calculated for taxa with differential abundance in the fecal microbiomes of R and NR, as indicated. Length indicates the effect size associated with a taxon. p = 0.05 for the test Petition 870260080213, dated 10 / 08 / 2026, page 45 / 398 35 / 296 Kruskal-Wallis; LDA score > 3. (E) Differentially abundant intestinal bacteria in R vs NR by the MW test (adjusted FDR) at all taxonomic levels. (F) Pairwise comparisons of bacterial species abundances identified by metagenomic WGS in 25 fecal samples: R (n = 14), NR (n = 11). *p < 0.05, **p < 0.01.

[00044] Figures 3A to F: The abundance of crOTUs in the gut microbiome is predictive of response to PD-1 blockade. (A) Unsupervised hierarchical clustering by complete linkage of crOTU abundances in 43 fecal samples. (B) Association of crOTU clusters with anti-PD-1 response by Fisher's exact test. crOTU cluster 1 (n = 14: R = 14, NR = 0); Cluster 2 (n = 29: R = 16, NR = 13). (C) KM plot of PFS by crOTU cluster. crOTU cluster (median PFS undefined), crOTU cluster 2 (median PFS = 242 days). (D) Differentially abundant fecal taxa in crOTU cluster 1 vs crOTU cluster 2, by the MW test (with adjusted FDR) at all taxonomic levels. (E) PFS in patients with high (n = 19, median PFS undefined) or low (n = 20, median PFS = 242 days) abundance of F. prausnitzii (top) or high (n = 20, median PFS = 188 days) or low (n = 19, median PFS = 393 days) abundance of Bacteroidales (bottom).(F) Unsupervised hierarchical clustering analysis of the abundances of pathway classes inferred from the predicted MetaCyc pathways in 28 fecal samples from 25 patients (R = 14, NR = 11). Normal font: biosynthetic pathways, bold font: degradative pathways. * p < 0.05.

[00045] Figures 4A to G: A favorable gut microbiome is associated with systemic antitumor immunity. (A) IHC quantification of pre-treatment CD8+ infiltrate in counts / mm2 in R (n = 15) and NR (n = 6) by one-tailed MW test. *p = 0.04. (B) Paired correlation heat map Petition 870260080213, dated 10 / 08 / 2026, page 46 / 398 (A) Spearman's 36 / 296 of significantly different taxa in fecal samples (n = 15) at baseline and density of CD3, CD8, PD-1, FoxP3, GzmB, and RORyT in counts / mm2 and PD-L1 by H-score in corresponding tumors. (B) Univariate linear regression between CD8+ / mm2 counts in the tumor versus Faecalibacterium (open circles and dashed line; r2 = 0.42, p = 0.0067) and Bacteroidales abundance (solid circles and continuous line; r2 = 0.056, p = 0.38) in the intestine. (D) Heat map of Spearman paired rank correlation between significantly different fecal taxa and frequency of CD4+ effector T cells, CD8+ T cells, myeloid dendritic cells, monocytes, B cells, Tregs, and MDSCs by flow cytometry in peripheral blood at baseline.(E) IHC multiplex showing representative images and (F) frequency of immune system cells, lymphoid cells, myeloid cells and MHC II in patients with high levels of Faecalibacterium or Bacteroidales in the gut. (G) Proposed mechanism of action of the gut microbiome in tumor immunity under favorable and unfavorable conditions.

[00046] Figures 5A and B. No differences were observed in the mutational profile of R and NR blockade to PD-1. (A) Number of mutations per megabase and driver mutation profile in tumors from patients with matching fecal microbiome samples (n = 7R vs 3NR). (B) Total non-synonymous mutational burden in available tumors (n = 8R vs 4NR, p = 0.683), by two-tailed Mann-Whitney (MW) test.

[00047] Figure 6: Differences in community structure between oral and fecal microbiomes. Bipartite network diagram of operational taxonomic units (OTUs) derived from bacterial 16S rRNA from 109 oral and 53 fecal samples. Borders connect the OTUs (diamonds) at the species level to sample nodes of the oral (open circles) and fecal (filled circles) samples in which they are found. Petition 870260080213, dated 10 / 08 / 2026, page 47 / 398 37 / 296

[00048] Figures 7A to C: Fecal microbiome diversity is increased in R therapy for anti-PD-1. Comparison of alpha diversity scores in R (n = 30, open circles) and NR (n = 13, filled circles) using the (A) Shannon, (B) Simpson and (C) Chaol indices by the two-tailed MW test. *p < 0.05, **p < 0.01.

[00049] Figures 8A to D: No differences in oral microbiome diversity were observed between the R and NR groups for anti-PD-1 therapy. Comparison of alpha diversity scores in the R (n = 54, open circles) and NR (n = 32, filled circles) groups using the (A) Inverse Simpson (p = 0.107), (B) Shannon (p = 0.139), (C) Simpson (p = 0.136) and (D) Chaol (p = 0.826) indices, by the two-tailed MW test.

[00050] Figures 9A and B: High fecal microbiome diversity is associated with longer PFS. Gut microbiota at baseline and during subsequent treatment per individual (n = 39). (A) Horizontal bars represent alpha diversity scores measured by Simpson's inverse index in each patient. (B) Timeline graphs showing days elapsed in therapy. x = progressed, o = did not progress at the last follow-up.

[00051] Figures 10A to D: Oral microbiome diversity is not associated with PFS. Oral microbiota and subsequent course of treatment by patient (n = 86). (A) Stacked bars represent the phylogenetic composition of each sample at the family level at baseline. All patients were classified into high (> 6.17), intermediate (3.26 to 6.17), and low (< 3.26) diversity groups, as indicated, based on tertiles of Simpson's inverse scores. (B) Kaplan-Meier plot of progression-free survival by tertiles of oral diversity: high (n = 29, mean PFS = 279 days), intermediate (n = 28, median PFS undefined), low (n = 29, median PFS = 348 days), as indicated. High vs Petition 870260080213, dated 10 / 08 / 2026, page 48 / 398 38 / 296 intermediate, p = 0.34; high vs low, p = 0.54 by the Mantel-Cox test. (C) Horizontal bars represent alpha diversity scores measured by Simpson's inverse index. (D) Timeline graphs showing days elapsed in therapy. x = progressed, o = did not progress at the last follow-up.

[00052] Figures 11A to D: thresholds for enrichment index (ei) scores and relative abundances of OTUs in 86 oral and 43 fecal microbiome samples. Distribution of enrichment scores for bacterial OTUs at the species level in microbiome samples by group (A) fecal and (B) oral. The limits for each set are indicated. Distribution of relative log10 abundance of species in microbiome samples (C) fecal and (D) oral. The range for each abundance category is indicated.

[00053] Figures 12A and B: There are no significant differences in oral microbiome OTUs between R and NR for antiPD-1 therapy by the enrichment index (ei) score. (A) Heat map of species abundance in R (n = 52) and NR (n = 34), as indicated, by bacterial OTU set based on ei scores. Each column denotes a patient and each row denotes a bacterial OTU. High, intermediate, and low are indicated. (B) Phylogenetic composition of bacterial OTUs within each set at the order level.

[00054] Figures 13A and B: High-dimensional class comparisons using LEfSe reveal greater abundance of Bacteroidales in the oral microbiome of NR for anti-PD-1 therapy. (A) LEfSe taxonomic cladogram showing differences in oral taxa. Taxa enriched in R and NR, respectively, are indicated with point size proportional to taxon abundance. (B) Histogram of LDA scores calculated for abundantly differentiated taxa between the oral microbiomes of R and NR, where bar length indicates effect size. Petition 870260080213, dated 10 / 08 / 2026, page 49 / 398 39 / 296 associated with a taxon. p = 0.05 for the Kruskal-Wallis test; LDA score > 3.

[00055] Figures 14A to C: The diversity and composition of the gut microbiome is stable over time. (A) Alpha diversity of the gut microbiome by inverse Simpson's test over time in 3 patients (R) with longitudinal collections. (B) Principal component analysis using unweighted UniFrac distances. (C) Stacked bars showing the composition of the gut microbiome in patients over time at the order level.

[00056] Figures 15A and B: Cluster analysis by relative abundances of OTU shows no association with response to anti-PD-1 therapy. Unsupervised hierarchical full linkage analysis using Euclidean distances based on OTU abundance in (A) 43 fecal microbiome samples and (B) 86 oral microbiome samples. Each column represents a single microbial sample, while each row represents a single OTU.

[00057] Figures 16A and B: Clusters based on crOTU oral microbiome abundances are not associated with response to PD-1 blockade. (A) Unsupervised hierarchical clustering analysis by complete linkage of 86 oral microbiome samples based on crOTU abundances. (B) Cluster comparison by response showing cluster 1 (n = 11, R = 9, NR = 2) and cluster 2 (n = 75, R = 45, NR = 30) of crotU. p = 0.20 by Fisher's exact two-tailed test.

[00058] Figure 17: Metabolic profiles based on KEGG- orthologs differ in the gut microbiome of R vs NR patients to PD-1 blockade. Unsupervised hierarchical clustering analysis of common functional pathways (found in at least 20 samples) in 28 fecal samples obtained from 25 patients (n = 14R and 11NR) according to the Petition 870260080213, dated 10 / 08 / 2026, page 50 / 398 40 / 296 relative abundances of the ortholog KEGG.

[00059] Figures 18A to F: Responders to PD-1 blockade show an immune infiltrate in the tumor enriched at the beginning of the study. Immunohistochemical quantification and representative images at 40X magnification of (A) CD3, (B) PD1, (C) FoxP3, (D) GzmB, (E) PD-L1 and (F) RORyT as counts / mm2 or H-score in responders (R) and non-responders (NR) to anti-PD-1.

[00060] Figure 19: Patients with high abundance of Faecalibacterium exhibit a favorable antitumor immune infiltrate before anti-PD-1 therapy. Heat map of Spearman rank correlation of GzmB, CD3, CD8, PD-1, FoxP3, and RORyT by counts / mm2, PD-L1 by H-score by IHC, and abundance of all genera of the Ruminococcaceae family in the fecal microbiome (n = 15). Positive correlation, negative correlation, and no correlation are indicated.

[00061] Figures 20A to F: The abundance of Faecalibacterium and Bacteroidales in the fecal microbiome has distinct associations with the immune infiltrate in the tumor prior to PD1 blockade. Linear regression between Faecalibacterium abundance, Bacteroidales abundance, and density by counts / mm2 or H-score of (A) CD3, (B) GzmB, (C) PD-1, (D) PD-L1, (E) FoxP3, and (F) RORyT by IHC in tumors from patients treated with anti-PD-1 at baseline. Lines show regression for Faecalibacterium (thin line, normal font values) and Bacteroidales (thick line, bold font values) with associated r2 and p values.

[00062] Figure 21: Gating strategy for peripheral blood flow cytometry analysis in patients treated with anti-PD-1 therapy. PBMCs at baseline in patients treated with anti-PD-1 were analyzed by gating for CD19+ B cells, CD3+CD8+ T cells, CD3+ T cells Petition 870260080213, dated 10 / 08 / 2026, p. 51 / 398 41 / 296 CD4+ (regulatory CD3+CD4+FoxP3+ and effector CD3+CD4+FoxP3-), monocytes (based on CD14 / HLA-DR) and MDSC (CD3-CD19-HLA-DRCD33+CD11b+).

[00063] Figures 22A to D: Patients with high abundance of Faecalibacterium exhibit a favorable peripheral cytokine profile for response to PD-1 blockade early on and increased cytokine responses during the course of therapy. (A) Spearman correlation heat map between abundance of Clostridiales, Faecalibacterium, Ruminococcaceae and Bacteroidal and peripheral cytokine concentration in pg / mL by multiplex bead assay. Positive correlation, negative correlation, and no correlation are indicated. Change in serum cytokine production of responders (n = 2) and non-responders (n = 2) to anti-PD-1 therapy for (B) IP-10 (p = 0.042 and p = 0.344, respectively), (C) MIP-Iβ (p = 0.043 and p = 0.898, respectively), and (D) IL-17A (p = 0.072 and p = 0.862, respectively) in times of change from baseline by paired t-test.

[00064] Figure 23: Gating strategy for multiplex myeloid IHC in tumors from patients treated with PD1 blockade at baseline. Multiplex myeloid immunohistochemistry gating strategy showing immune system cells (CD45+), lymphoid cells (CD45+CD3+CD20+CD56+), myeloid cells (CD45+CD3-CD20-CD56-), mast cells (CD45+CD3-CD20-CD56-HLADR-tryptase+), granulocytes (CD45+CD3-CD20-CD56-HLADRCD66b+), M1 tumor-associated macrophages (CD45+CD3-CD20-CD56-HLADR+CSF1R+CD163-), M2 tumor-associated macrophages (CD45+CD3-CD20-CD56-HLADR+CSF1R+CD163+), mature dendritic cells (CD45+CD3-CD20-CD56-HLADR+CSF1R-DCSIGN-). and immature dendritic cells (CD45+CD3-CD20-CD56-HLADR+CSF1RDCSIGN+). [000 65] Figures 24A to C: High baseline abundance of Faecalibacterium is associated with an increase Petition 870260080213, dated 10 / 08 / 2026, page 52 / 398 42 / 296 of the immune infiltrate before PD-1 blockade. (A) Multiplex immunohistochemistry showing representative immune system myeloid cell staining at 40X magnification. (B) Quantification of CD45, CD3 / CD20 / CD56, CD68, CD66b, tryptase, HLA-DR, CD163 and DC-SIGN as counts / mm2. (C) Quantification of myeloid cells, lymphoid cells, mast cells, granulocytes, M1 and M2 tumor-associated macrophages, immature dendritic cells, and mature dendritic cells as a percentage of total CD45+ immune system cells in patients with high abundance of Faecalibacterium (n = 2) or high abundance of Bacteroidales (n = 2). [000 66] Figures 25A and B: Fecal microbiota transplantation (FMT) of a favorable gut microbiome in germ-free (GF) mice reduces tumor growth. (A) Experimental design of the FMT1 experiment in germ-free (GF) mice. Time is indicated in days (D) relative to the day of tumor injection (8 x 10-5 tumor cells). (B) Difference in tumor size implanted in FMT-responder (R) and non-responder (NR) mice, or control mice. Tumor volumes on day 14 after tumor implantation are plotted, with each value representing a single mouse.

[00067] Figures 26A to C: Favorable FMT promotes innate and reduced effector myeloid infiltration in the spleen of GF mice. (A) Flow cytometry quantification showing the frequency of CD45+ immune system cells in R-FMT (R), NR-FMT (NR) and control mice (C) in the spleen. (B) Flow cytometry quantification showing the frequency of CD45+CD11b+Ly6G+ innate effector cells in RFMT (R), NR-FMT (NR) and control mice (C) in the spleen. (C) Flow cytometry quantification showing the frequency of CD45+CD11b+CD11c+ suppressor cells in R-FMT (R), NR-FMT (NR) and control mice (C) in the spleen. Petition 870260080213, dated 10 / 08 / 2026, page 53 / 398 43 / 296 [000 68] Figures 27A to C: Favorable FMT increases CD45+ and CD8+ levels in the gut and tumor of GF mice. Representative immunofluorescence staining of (A) tumor and (B) gut of control (left), NR-FMT (middle), and R-FMT (right) tumor groups in GF mice after FMT for CD45, CD8, and nuclei (DAPI). (C) Quantification of CD8+ density in R-FMT tumor (top) (n = 2, median = 433.5 cells / HPF in 12 regions), NR-FMT (NR-FMT n = 2, median = 325 cells / HPF in 12 regions) and control mice (n = 2, median = 412 cells / HPF in 9 regions). p = 0.30 (R-FMTvs Control) and lower intestine (R-FMT n = 2, median = 67 cells / HPF in 7 regions, NR-FMT n = 2, median = 24 cells / HPF in 5 regions, control n = 2, median = 47 cells / HPF in 10 regions). p = 0.17 (R-FMT vs control). [000 69] Figures 28A to C: FMT of a favorable gut microbiome in GF mice reduces tumor growth and increases response to α-PD-L1 therapy. (A) Experimental design of the FMT2 experiment in germ-free (GF) mice. Time is indicated in days (D) relative to the day of tumor injection (2.5 x 10-5 tumor cells). (B) Difference in size of implanted tumors in R-FMT (R, squares) and NR-FMT (NR, triangles) mice, or control mice (circles). Tumor volumes on day 14 after tumor implantation are plotted, with each value representing a single mouse. (C) Tumor growth curves for each GF mouse treated with α-PDL1 (3 x 100 μg ip every 3 days) R-FMT mice (squares, n = 2, median tumor volume = 403.7 mm3), NR-FMT mice (triangles, n = 2, median tumor volume = 2301 mm3) and control mice (circles, n = 2, median tumor volume = 771.35 mm3).p = 0.20 (R-FMT vs NR-FMT), p = 0.33 (NR-FMT vs control by bilateral MW test). The black dotted line marks the tumor size limit for treatment with α-PD-L1 (500. Petition 870260080213, dated 10 / 08 / 2026, p. 54 / 398 44 / 296 mm3) .

[00070] Figures 29A to E: Enhanced therapeutic response via favorable FMT correlates with increased innate effector and reduced myeloid suppressor infiltration in tumors in GF mice. (A) Flow cytometry quantification showing the frequency of CD45+ immune system cells in R-FMT, NR-FMT, and control mice infiltrating the tumor, as indicated. (B) Representative flow cytometry graphs of CD45+CD11b+Ly6G+ innate effector cells and (D) CD11b+CD11c+ myeloid suppressor cells in control (left), NR-FMT (middle), and R-FMT (right) mice. (C) Quantification by flow cytometry showing the frequency of innate effector cells CD45+CD11b+Ly6G+ and (E) suppressor cells CD45+CD11b+CD11c+ in R-FMT, NR-FMT and control mice infiltrating the tumor, as indicated.

[00071] Figures 30A to D: GF mice receiving FMT from the NR donor have a highly activated Th17 compartment. (A) Representative IHC staining images for mice with the orphan retinoic acid-related receptor gamma t (RORyT), the nuclear receptor in R-FMT (right), NRFMT (middle), and control (left) tumors. Arrows point to RORyT-positive cells. (B) IHC quantification showing the number of RORyT+ Th17 cells in R-FMT (R), NR-FMT (NR), and control mice (C) in tumors as counts / mm2. (C) Flow cytometry quantification showing the frequency of CD4+FoxP3+ regulatory T cells in R-FMT (R), NR-FMT (NR), and control mice (C) in the spleen. (D) Quantification by flow cytometry showing the frequency of CD4+IL17+Th17 cells in R-FMT (R), NR-FMT (NR) and control mice (C) in the spleen.

[00072] Figures 31A and B: PD-L1 upregulation in the tumor microenvironment of mice receiving R-FMT versus NR-FMT by mass cytometry (CyTOF). (A) t-SNE plot Petition 870260080213, dated 10 / 08 / 2026, page 55 / 398 (A) Total live cells (left) isolated from tumors derived from control, NR- and R- colonized mice, as indicated, by mass cytometry. Total live cell t-SNE plot superimposed with CD45 (middle) and PDL1 (right) expression. Equal numbers of cells are shown from each group. (B) Total CD45+ cell t-SNE plot (upper left) isolated from tumors derived from control, NR-FMT and R-FMT mice, as indicated, by CyTOF. Total live cell t-SNE plot superimposed with CD45 (middle) and PDL1 (right) expression. Equal numbers of cells are shown from each group.

[00073] Figures 32A to C: FMT from another R donor in GF mice confirms the impact of a favorable gut microbiome on tumor growth. (A) Experimental design of the FMT2 experiment in germ-free (GF) mice. Time is indicated in days (D) relative to the day of tumor injection (2.5 x 10-5 tumor cells). (B) Difference in size of implanted tumors in R-FMT (squares) and NR-FMT (triangles) mice, or in control mice (circles). Tumor volumes on day 14 after tumor implantation are plotted, with each value representing a single mouse. (C) Tumor growth curves for each GF mouse of R-FMT mice (square, tumor volume = 414.3 mm3), NR-FMT mice (triangle, tumor volume = 1,909.1 mm3) and control mice (circle, n = 3, median tumor volume = 1,049.3 mm3).

[00074] Figures 33A to 33F: Genetically identical C57 / BL6 Jackson and Taconic mice exhibit differential tumor growth (earlier in Jackson) (A), survival (higher in Taconic) (BC), and microbiome composition (Taconic housed individually, upper right; Jackson housed individually, lower right) (D) after the Petition 870260080213, dated 10 / 08 / 2026, page 56 / 398 46 / 296 implantation of murine melanoma tumors (BRAF-mutant, PTEN-null). Co-housing of Taconic and Jackson mice resulted in similar tumor growth (C), and greater microbiome similarity was observed by principal coordinate analysis (D). Differential abundance at the genus level was observed in individually housed Jackson and Taconic mice, but no difference was observed after co-housing (E). Oral administration of butyrate significantly delayed tumor development in mice implanted with melanoma tumors (F).

[00075] Figures 34A to C: 16S analysis of fecal samples from R and NR donors and germ-free recipient mice. Comparisons of relative abundance of (A) Faecalibacterium, (B) Ruminococcaceae, and (C) Bacteroidales on day 14 after tumor injection. Data from 2 independent experiments are presented. **p < 0.01. DESCRIPTION OF ILLUSTRATIVE MODALITIES

[00076] Great advances have been made in cancer therapy through the use of molecularly targeted therapy and immunotherapy; however, responses are variable and not always durable. Treatment with immune checkpoint inhibitors is associated with response rates of 15 to 40% in patients with disseminated melanoma, and efforts are being made to identify strategies to improve responses to checkpoint inhibitor therapy. Thus, methods to improve therapeutic responses, as well as to increase the number of responders, are critically needed.

[00077] The present disclosure overcomes the problems with current technologies by providing methods to modulate the microbiome to improve the immune response to cancer and the therapeutic response to immune checkpoint inhibitors in cancer patients. Studies in the present Petition 870260080213, dated 10 / 08 / 2026, page 57 / 398 47 / 296 revelation used a large cohort of patients with metastatic melanoma undergoing systemic treatment (n = 233), and a subset of these were treated with PD-1-based immunotherapy (n = 112).

[00078] Oral and intestinal microbiome samples were characterized in these patients through 16S rRNA gene sequencing and metagenomic whole-genome shotgun sequencing. In these analyses, significant differences were observed in the diversity and composition of the intestinal microbiome in responders compared to non-responders to immune checkpoint blockade therapy (e.g., PD-1-based therapy), with significantly greater diversity and abundance of specific bacteria (e.g., from the order Clostridiales and the family Ruminococcaceae) in the intestinal microbiome of responders compared to non-responders. In particular, the species Faecalibacterium prausnitzii was found to be more abundant in responders.These bacteria are known to produce short-chain fatty acids, such as butyrate, which help maintain the integrity of specific cells within the intestine (i.e., enterocytes) and may boost immunity.

[00079] Interestingly, it was observed that non-responders to therapy had low levels of these bacteria and significantly higher levels of bacteria of the order Bacteroidales, which has been shown in some studies to downregulate systemic immune responses. Metagenomic analysis via shotgun sequencing of the whole genome was performed on a subgroup of these patients, validating these findings, and further demonstrated differences in metabolic processes in bacteria from responders versus non-responders. In addition, it was shown that the modulation of the gut microbiome by co-hospitalization with Taconic mice Petition 870260080213, dated 10 / 08 / 2026, page 58 / 398 Studies in mice with a less favorable gut microbiome (Jackson mice) and oral administration of short-chain fatty acids (e.g., butyrate) resulted in delayed tumor development in mice with a less favorable gut microbiome. These results from human and murine studies have potentially far-reaching implications for improving responses to immune checkpoint blockade through modulation of the gut microbiome.

[00080] Importantly, the present studies show that patients with a favorable gut microbiome (with high diversity and high relative abundance of bacteria from the order Clostridiales and / or the family Ruminococcaceae) exhibit enhanced systemic and antitumor immune responses mediated by increased antigen presentation at the lymph node and tumor level, as well as preserved effector T cell function in the periphery and tumor microenvironment. On the other hand, patients with an unfavorable gut microbiome (with low diversity and high relative abundance of bacteria from the order Bacteroidales) have impaired systemic and antitumor immune responses, mediated by limited intratumoral infiltration of both lymphoid and myeloid elements, weakened antigen presentation capacity, and a bias towards cellular and humoral immunoregulatory elements in the periphery, including Treg and MDSC.

[00081] Other studies have also been conducted in a mouse melanoma model system. These studies showed that mice that received fecal microbiota transplantation from a responder population exhibited decreased tumor growth and increased response to anti-PD1 therapy. Furthermore, mice that received transplantation from a responder microbial population showed higher percentages of innate effector cells (expressing CD45+CD11b+Ly6G+) and lower frequencies of cells Petition 870260080213, dated 10 / 08 / 2026, page 59 / 398 49 / 296 myeloid suppressor cells (expressing CD11b+CD11c+) in the spleen, as well as an increase in the number of immune CD45+ and CD8+ T cells in the gut. These findings highlight the potential for parallel modulation of the gut microbiome to significantly increase the efficacy of checkpoint blocking, warranting prompt evaluation in clinical trials.

[00082] Based on these findings, methods for treating and diagnosing cancer are provided in the present invention. In one method, short-chain fatty acids, such as butyrate, and / or a population of short-chain fatty acid-producing bacteria are administered to patients during immune checkpoint blockade treatment to enhance therapeutic responses. Methods are also provided herein for using the diversity and composition of the gut microbiome as a predictive biomarker to identify patients who will have a favorable response to immune checkpoint blockade. I. Definitions

[00083] As used herein, essentially exempt in the context of a specific component, is used in the present invention to mean that none of the specified components were purposefully formulated into a composition and / or are present only as a contaminant or in trace amounts. The total amount of the specified component resulting from any accidental contamination of a composition is therefore well below 0.01%. A composition in which no amount of the specified component can be detected by standard analytical methods is more preferred.

[00084] As used in the present invention, one or an may mean one or more than one.

[00085] The use of the term or in the claims is used for Petition 870260080213, dated 10 / 08 / 2026, page 60 / 398 50 / 296 means and / or, unless explicitly indicated to refer to only one or if the alternatives are mutually exclusive, although the disclosure bases a definition that refers only to and / or alternatives. As used herein, the term other may mean at least one or more.

[00086] Throughout this application, the term approximately is used to indicate that a value includes the inherent error variation for the device, the method being employed to determine the value, or the variation that exists between individuals in the study.

[00087] The phrase “effective amount” or “therapeutically effective amount” or “sufficient amount” means a dosage of a drug or agent that is sufficient to produce a desired result.The desired outcome may be a decrease in tumor size, a decrease in the growth rate of cancer cells, a decrease in metastasis, an increase in CD8+ T lymphocytes in the tumor or immune infiltrate in the tumor, an increase in CD45+, CD3+ / CD20+ / CD56+, CD68+ and / or HLA-DR+ cells in the tumor, an increase in the expression of CD3, CD8, PD1, FoxP3, granzyme B and / or PD-L1 in a tumor immune infiltrate, a decrease in the expression of RORyT in an immune infiltrate in the tumor, an increase in CD4+, CD8+ effector T cells, monocytes and / or myeloid dendritic cells in the systemic circulation or peripheral blood, a decrease in B cells, regulatory T cells and / or myeloid-derived suppressor cells in the systemic circulation or peripheral blood of the individual, or any combination of these outcomes.

[00088] The term tumor cell or cancerous cell denotes a cell that exhibits inappropriate and unregulated proliferation. A human tumor is composed of cells that possess human chromosomes. These tumors include those in a human patient and tumors resulting from the introduction into a non-human animal host of a malignant cell lineage. Petition 870260080213, dated 10 / 08 / 2026, page 61 / 398 51 / 296 with human chromosomes.

[00089] As used in the present invention, the term antibody refers to an immunoglobulin, its derivatives that retain specific binding capacity, and proteins with a binding domain that is homologous or largely homologous to an immunoglobulin binding domain. These proteins may be derived from natural sources, or may be partially or wholly produced synthetically. An antibody may be monoclonal or polyclonal. The antibody may be a member of any immunoglobulin class, including any of the human classes: IgG, IgM, IgA, IgD, and IgE. The antibodies used with the methods and compositions described herein are generally derived from the IgG class. The term antibody also refers to antigen-binding antibody fragments. Examples of such antibody fragments include, but are not limited to, Fab, Fab', F(ab')2, scFv, Fv, dsFv, and Fd fragments. Antibody fragments may be produced by any means.For example, the antibody fragment may be enzymatically or chemically produced by fragmentation of an intact antibody, it may be recombinantly produced from a gene encoding a partial antibody sequence, or it may be produced wholly or partially by synthetic means. The antibody fragment may optionally be a single-chain antibody fragment. Alternatively, the fragment may comprise multiple chains that are linked together, for example, by disulfide bonds. The fragment may also optionally be a multimolecular complex. A functional antibody fragment retains the ability to bind to its cognate antigen with affinity comparable to the complete antibody.

[00090] The term monoclonal antibody, as used herein, refers to an antibody obtained from a population of antibodies. Petition 870260080213, dated 10 / 08 / 2026, page 62 / 398 52 / 296 substantially homogeneous, for example, the individual antibodies comprising the population are identical except for possible mutations, for example, naturally occurring ones, which may be present in minor quantities. Thus, the monoclonal modifier indicates the character of the antibody as not being a mixture of discrete antibodies. In certain embodiments, such a monoclonal antibody typically includes an antibody comprising a target-binding polypeptide sequence, wherein the target-binding polypeptide sequence was obtained by a process that includes the selection of a single target-binding polypeptide sequence from a plurality of polypeptide sequences. For example, the selection process may be the selection of a single clone from a plurality of clones, such as a pool of hybridoma clones, phage clones, or recombinant DNA clones.It should be understood that a selected target binding sequence can be further altered, for example, to improve affinity to the target, to humanize the target binding sequence, to improve its production in cell culture, to reduce its immunogenicity in vivo, to create a multispecific antibody, etc., and that an antibody comprising the altered target binding sequence is also a monoclonal antibody of this development. Unlike polyclonal antibody preparations, which typically include several different antibodies directed against different determinants (epitopes), each monoclonal antibody in a monoclonal antibody preparation is directed against a single determinant on an antigen. In addition to their specificities, monoclonal antibody preparations are advantageous in that they are typically contaminated by other immunoglobulins.

[00091] The phrases pharmaceutical composition or pharmacologically acceptable composition refer to the entities and Petition 870260080213, dated 10 / 08 / 2026, page 63 / 398 53 / 296 molecular compositions that do not produce an adverse, allergic or otherwise undesirable reaction when administered to an animal, as well as to a human being, as appropriate. The preparation of a pharmaceutical composition comprising an antibody or additional active ingredient will be known to persons skilled in the art in light of this disclosure. Furthermore, for animal administration (e.g., to humans), it will be understood that the preparations must meet the standards of sterility, pyrogenicity, general safety and purity as required by the FDA Office of Biological Standards.

[00092] As used in the present invention, “pharmaceutically acceptable vehicle” includes any and all aqueous solvents (e.g., water, aqueous / alcoholic solutions, saline solutions, parenteral vehicles such as sodium chloride and Ringer's dextrose), non-aqueous solvents (e.g., propylene glycol, polyethylene glycol, vegetable oil and injectable organic esters such as ethyl oleate), dispersing media, coatings, surfactants, antioxidants, preservatives (e.g., antibacterial or antifungal agents, antioxidants, chelating agents and inert gases), isotonic agents, absorption retardants, salts, drugs, drug stabilizers, gels, binders, excipients, disintegrating agents, lubricants, sweetening agents, flavoring agents, colorants, fluid and nutrient replenishers, such as absorbent materials and combinations thereof, as would be known to a person normally skilled in the art.The pH and exact concentration of the various components in the pharmaceutical composition can be adjusted according to well-known parameters.

[00093] The term “unit dose” or dosage refers to physically discrete units suitable for use in a Petition 870260080213, dated 10 / 08 / 2026, page 64 / 398 54 / 296 individual, with each unit containing a predetermined amount of the therapeutic composition calculated to produce the desired responses discussed above, along with its administration, i.e., the appropriate route and treatment regimen. The amount to be administered, both according to the number of treatments and the unit dose, depends on the desired effect. The effective dosage amount of a composition of the present modalities administered to a patient or individual may be determined by physical and physiological factors, such as the individual's body weight, age, health status and sex, the type of disease to be treated, the extent of disease penetration, previous or concomitant therapeutic interventions, the patient's idiopathic condition, the route of administration, and the potency, stability and toxicity of the particular therapeutic substance. For example, a dose may also range from about 1 μg / kg / body weight to about 1.000 mg / kg / body weight (this range includes intervening doses) or more per administration, and any particular dose derived therefrom. By non-limiting examples of a derivable range from the numbers listed here, a range of about 5 μg / kg / body weight to about 100 mg / kg / body weight, from about 5 μg / kg / body weight to about 500 mg / kg / body weight, etc., may be administered. The administering physician will determine, in any case, the concentration of active ingredient(s) in a composition and the appropriate dose(s) for the individual.

[00094] An anticancer agent is capable of negatively affecting a cancerous / tumor cell in an individual, for example, by promoting the death of cancerous cells, inducing apoptosis in cancerous cells, reducing the growth rate of cancerous cells, reducing the incidence or number of metastases, reducing the size of the tumor, Petition 870260080213, dated 10 / 08 / 2026, page 65 / 398 55 / 296 inhibiting tumor growth, reducing blood supply to a tumor or cancer cells, promoting an immune response against cancer cells or a tumor, preventing or inhibiting cancer progression, or increasing the lifespan of an individual with cancer.

[00095] The term immune checkpoint refers to a component of the immune system that provides inhibitory signals to its components in order to regulate immune reactions. Known immune checkpoint proteins include CTLA-4, PD-1 and their ligands PD-L1 and PD-L2, and in addition, LAG-3, BTLA, B7H3, B7H4, TIM3, KIR. The pathways involving LAG3, BTLA, B7H3, B7H4, TIM3 and KIR are recognized in the art as constituting immune checkpoint pathways similar to CTLA-4 and PD-1 dependent pathways (see, for example, Pardoll, 2012, Nature Rev Cancer 12:252-264; Mellman et al., 2011, Nature 480:480-489).

[00096] The term PD-1 axis binding antagonist refers to a molecule that inhibits the interaction of a PD-1 axis binding partner with one or more of its binding partners, so as to remove T cell dysfunction resulting from signaling in the PD-1 signaling axis, with the result of restoring or enhancing T cell function (e.g., proliferation, cytokine production, and / or target cell death). The term “PD-1 axis” refers to any component of the PD1 immune checkpoint (e.g., PD-1, PD-L1, and PD-L2). As used in the present invention, a PD-1 axis binding antagonist includes a PD-1 binding antagonist, a PD-L1 binding antagonist, and a PD-L2 binding antagonist.

[00097] The term PD-1 binding antagonist refers to a molecule that reduces, blocks, inhibits, cancels, or interferes with the signal transduction resulting from the interaction of PD-1 with Petition 870260080213, dated 10 / 08 / 2026, p. 66 / 398 56 / 296 one or more of its binding partners, such as PD-L1 and / or PD-L2. A PD-1 binding antagonist can be a molecule that inhibits the binding of PD-1 to one or more of its binding partners. In a specific aspect, a PD-1 binding antagonist inhibits the binding of PD-1 to PD-L1 and / or PD-L2. For example, PD-1 binding antagonists include anti-PD-1 antibodies, their antigen-binding fragments, immunoadhesins, fusion proteins, oligopeptides, and other molecules that reduce, block, inhibit, nullify, or interfere with signal transduction resulting from the interaction of PD-1 with PD-L1 and / or PD-L2. An exemplary PD-1 binding antagonist is an anti-PD-1 antibody. For example, the PD-1 binding antagonist is MDX-1106 (nivolumab), MK3475 (pembrolizumab), CT-011 (pidilizumab), or AMP-224.

[00098] The term PD-L1 binding antagonist refers to a molecule that reduces, blocks, inhibits, cancels, or interferes with the signal transduction resulting from the interaction of PD-L1 with one or more of its binding partners, such as PD-1 or B7-1. For example, a PD-L1 binding antagonist is a molecule that inhibits the binding of PD-L1 to its binding partners. In a specific aspect, the PD-L1 binding antagonist inhibits the binding of PD-L1 to PD-1 and / or B7-1. PD-L1 binding antagonists may include anti-PD-L1 antibodies, their antigen-binding fragments, immunoadhesins, fusion proteins, oligopeptides, and other molecules that decrease, block, inhibit, cancel, or interfere with the signal transduction resulting from the interaction of PD-L1 with one or more of its binding partners, such as PD-1 or B7-1.For example, a PD-L1 binding antagonist reduces the negative costimulatory signal mediated by or through cell surface proteins expressed in T lymphocyte-mediated signaling via PD-L1, so as to make a dysfunctional T cell less dysfunctional (e.g., by increasing the...). Petition 870260080213, dated 10 / 08 / 2026, page 67 / 398 57 / 296 effector responses to antigen recognition). In one example, a PD-L1 binding antagonist is an anti-PD-L1 antibody. The anti-PD-L1 antibody could be YW243.55.S70, MDX1105, MPDL3280A, or MEDI4736.

[00099] The term PD-L2 binding antagonist refers to a molecule that reduces, blocks, inhibits, cancels, or interferes with the signal transduction resulting from the interaction of PD-L2 with one or more of its binding partners, such as PD-1. A PD-L2 binding antagonist may be a molecule that inhibits the binding of PD-L2 to one or more of its binding partners. For example, a PD-L2 binding antagonist inhibits the binding of PD-L2 to PD-1, such as anti-PD-L2 antibodies, their antigen-binding fragments, immunoadhesins, fusion proteins, oligopeptides, and other molecules that decrease, block, inhibit, cancel, or interfere with the signal transduction resulting from the interaction of PD-L2 with one or more of its binding partners, such as PD-1. [000100] An immune checkpoint inhibitor refers to any compound that inhibits the function of an immune checkpoint protein. Inhibition includes both reduced function and complete blockage. In particular, the immune checkpoint protein is a human immune checkpoint protein. Thus, an immune checkpoint protein inhibitor is, in particular, an inhibitor of a human immune checkpoint protein. [000101] Individual and patient refer to a human or non-human being, such as primates, mammals, and vertebrates. In particular modalities, the individual is a human being. [000102] As used in the present invention, the terms “treat”, “treatment”, “treating” or “improvement”, when used in reference to a disease, disorder or condition Petition 870260080213, dated 10 / 08 / 2026, page 68 / 398 58 / 296 medical, refers to therapeutic treatments for a condition, where the objective is to reverse, alleviate, improve, inhibit, delay, or halt the progression or severity of a symptom or condition. The term treating includes reducing or alleviating at least one adverse effect or symptom of a condition. Treatment is generally effective if one or more symptoms or clinical markers are reduced. Alternatively, treatment is effective if the progression of a condition is reduced or halted. That is, treatment includes not only the improvement of symptoms or markers, but also a cessation or at least a delay in the progression or worsening of symptoms that would be expected in the absence of treatment.Beneficial or desired clinical outcomes include, but are not limited to, relief of one or more symptoms, reduction in the extent of impairment, stabilization (i.e., no worsening) of a tumor or malignancy, delay or slowing of tumor growth and / or metastasis, and increased life expectancy compared to that expected in the absence of treatment. [000103] The gut microbiota or gut microbiome refers to the population of microorganisms that live in an individual's intestine. [000104] The term alpha diversity is a measure of diversity within a sample and refers to the distribution patterns and the entire set of microbiota within samples, and is calculated as a scalar value for each sample. The term beta diversity is a term for diversity between samples, and involves comparing samples to each other, which provides a measure of the distance or dissimilarity between each pair of samples. [000105] The term relative quantity, which can also be referred to as relative abundance, is defined as the number of bacteria of a given taxonomic level (from phylum to phylum). Petition 870260080213, dated 10 / 08 / 2026, page 69 / 398 59 / 296 species) as a percentage of the total number of bacteria at that level in a biological sample. This relative abundance can be assessed, for example, by measuring the percentage of 16S rRNA gene sequences present in the sample that are attributed to these bacteria. It can be measured by any appropriate technique known to those skilled in the art, such as pyrosequencing 454 and quantitative PCR of these specific bacterial 16S rRNA gene markers or quantitative PCR of a specific gene. [000106] In this text, a “good responder to treatment,” also called a “responder” or “responsive” patient, or in other words, a patient who “benefits from this treatment,” refers to a cancer patient who shows or will show clinically significant cancer relief after receiving this treatment. Conversely, a “poor responder” or “non-responder” is one who does not demonstrate or will not demonstrate clinically significant cancer relief after receiving this treatment. Decreased response to treatment can be assessed according to recognized standards in the art, such as the immune-related response (irRC) criteria, WHO criteria, or RECIST. [000107] The term isolate encompasses a substance and / or other entity or substance that has been (1) separated from at least some of the components with which it was associated when it was initially produced (either in nature or in an experimental setting); and / or (2) artificially produced, prepared, purified, and / or manufactured. Isolated bacteria may be separated from at least about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90% or more of the other components with which they were initially associated. In some embodiments, isolated bacteria are Petition 870260080213, dated 10 / 08 / 2026, p. 70 / 398 60 / 296 more than about 80%, about 85%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, about 99% or more than about 99% pure. As used in the present invention, a substance is pure if it is substantially free of other components. [000108] The terms “purify,” “purifying,” and “purified” refer to a bacterium or other material that has been separated from at least some of the components with which it was associated when it was initially produced or generated (e.g., in nature or in an experimental setting), or during any time after its initial production. A bacterium or bacterial population may be considered purified if it is isolated during or after production, such as from a material or environment containing the bacterium or bacterial population, and a purified bacterium or bacterial population may contain other materials up to about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or above 90% and still be considered “isolated.”In some embodiments, the purified bacteria and bacterial populations are more than about 80%, about 85%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, or more than about 99% pure. In the case of the bacterial compositions provided herein, one or more bacterial types present in the composition may be purified independently of one or more other bacteria produced and / or present in the material or environment containing the bacterial type. The bacterial compositions and their bacterial components are generally purified from residual habitat products. II. Purified bacterial population Petition 870260080213, dated 10 / 08 / 2026, p. 71 / 398 61 / 296 [000109] The embodiments of the present disclosure relate to compositions containing short-chain fatty acids, such as butyrate-containing compositions, and purified bacterial populations (e.g., bacterial populations containing short-chain fatty acids, such as butyrate-producing bacterial populations) for the treatment of cancer, such as in an individual receiving or who has received an immune checkpoint inhibitor. In some embodiments, the individual receives a prebiotic and / or probiotic to enrich the butyrate-producing bacteria. In certain aspects, the individual undergoes dietary changes to enrich the butyrate-producing bacteria. [000110] In certain embodiments, the present disclosure provides probiotic compositions and live bacterial products comprising bacterial populations beneficial to the therapeutic immune checkpoint response. The probiotic composition may comprise bacteria of the phylum Firmicutes. The bacterial population may belong to the class Clostridia, specifically to the order Clostridales, or one or more bacterial populations may belong to the family Clostridiaceae, Ruminococcaceae (e.g., specifically to the genus Ruminococcus or the genus Faecalibacterium), Micrococcaceae (e.g., specifically to the genus Rothia), Lachnospiraceae and / or Veilonellaceae. In other aspects, the bacterial population may belong to the phylum Tenericutes, particularly to the class Mollicutes. The bacteria may belong to the genus Peptoniphilus, particularly to the species P. asaccharolyticus, P. gorbachii, P. harei, P. ivorii, P. lacrimalis, and / or P. olsenii.Other exemplary bacterial populations for probiotic composition may include bacterial populations belonging to the genus Porphyromonas, particularly the species Porphyromonas pasteri, the species Clostridium hungatei, and the genus. Petition 870260080213, dated 10 / 08 / 2026, page 72 / 398 62 / 296 Phascolarctobacterium or the species Phascolarctobacterium faecium. [000111] For example, bacterial populations of the genus Ruminococcus may include bacteria of the species Ruminococcus albus, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus flavefaciens, Ruminococcus champanellensis, Ruminococcus faecis, Ruminococcus gauvreauii, Ruminococcus gnavus, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus lactaris, Ruminococcus luti, Ruminococcus obeum, Ruminococcus palustris, Ruminococcus pasteurii, Ruminococcus productus, Ruminococcus schinkii, and / or Ruminococcus torques. Bacterial populations of the genus Faecalibacterium may include bacteria of the species Faecalibacterium prausnitzii. [000112] Populações bacterialanas exemplificadoras do genus Rothia podem incluir bacteria das species R. aeria, R. amarae, R. dentocariosa, R. endophytica, R mucilaginosa, R. nasimurium and / or R. terrae. [000113] Exemplary bacterial populations for inclusion in the probiotic composition include bacterial populations belonging to the phylum Firmicutes, class Clostridia, family Ruminococcaceae, species Faecalibacterium prausnitzii, genus Ruminococcus, species Porphyromonas pasteri, family Veilonellaceae, species Colostridium hungatei, genus Phascolarctobacterium, species Phascolarctobacterium faecium, genus Peptoniphilus, family Micrococcaceae, class Mollicutes and / or the genus Rothia. In particular aspects, the probiotic composition or live bacterial product does not comprise bacterial populations of the order Bacteroidales, such as those of the genus Bacteroides, and particularly those of the species B. thetaiotaomicron, B. fragilis, B. vulgatus, B. distasonis, B. ovatus, B. stercoris, B. merda, B. uniformis, B. eggerithii or B. caccae. In Petition 870260080213, dated 10 / 08 / 2026, page 73 / 398 63 / 296 in particular, the probiotic composition does not include bacterial populations of the genus Gardnerella or of the species Collinsella stercoris, Desulfovibrio alaskensis, Bacteroides mediterraneensis, Prevotella histicola or Gardnerella vaginalis. Petition 870260080213, dated 10 / 08 / 2026, page 74 / 398 64 / 296 Table 1: Operational taxonomic units of sets 1 to 3 OTU_ s Set Taxon ID Phylum Class Order Family Genus Species ei OTU_ 219 SET 3 28113 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides heparinolyticus -1.00 OTU_ 140 SET 3 1852370 Bacteroidetes Bacteroidia Bacteroidales Prevoteilaceae Prevotellamassilia Prevotellamassilia timonensis -1.00 OTU_ 320 SET 3 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 -1.00 OTU_ 166 SET 3 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale -1.00 OTU_ 1381 SET 3 1348613 Firmicutes Clostridia Clostridiales Defluviitaleaceae Vallitalea Vallitalea pronyensis -0.64 OTU_ 2558 SET 3 1841856 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides mediterraneensis -1,00 OTU_ 788 SET 3 1002367 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella stercorea DSM 18206 -1.00 OTU_ 1772 SET 3 1841856 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides mediterraneensis -1.00 OTU_ 2085 SET 3 58134 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Desuifotomaculum] guttoideum -1.00 OTU_ 648 SET 3 1527 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerocolumna Anaerocolumna aminovalerica -1.00 OTU_ 623 SET 3 187979 Firmicutes Negativicutes Selenomonadales Selenomonadaceae Mitsuokella Mitsuokella j alaludinii -1.00 OTU_ 671 SET 3 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis -1.00 OTU_ 600 SET 3 387661 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides johnsonii -1,00 OTU_ 1038 SET 3 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis -1.00 OTU_ 2899 SET 3 357276 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides dorei -0.64 OTU_ 1079 SET 3 45254 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Dysgonomonas Dysgonomonas capnocytophagoides -1.00 OTU_ 546 SET 3 762984 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides clarus PIT 12056 -1.00 OTU SET 544645 Bacteroidetes Bacteroidia Bacteroidales Odoribacteiaceae Butyricimonas Butyricimonas -0.55, Petition 870260080213, dated 10 / 08 / 2026, p. 75 / 398 65 / 296 1213 3 virosa OTU_ 823 SET 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -0.55 OTU_ 954 SET 3 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale -1.00 OTU_ 886 SET 3 537011 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella copri DSM 18205 -0.55 OTU_ 2805 SET 3 52226 Firmicutes Negativicutes Selenomonadales Selenomonadaceae Mitsuokella Mitsuokella multacida -1.00 OTU_ 611 SET 3 742742 Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella Collinsella tanakaei YIT 12063 -1.00 OTU_ 1853 SET 3 291644 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides salyersiae -1.00 OTU_ 1691 SET 3 484018 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides plebeius DSM 17135 -100 OTU_ 2206 CONJUNTO 3 484018 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides plebeius DSM 17135 -1,00 OTU_ 749 CONJUNTO 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -0,64 OTU_ 2557 CONJUNTO 3 1841856 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides mediterraneensis -1,00 OTU_ 2249 CONJUNTO 3 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis -1,00 OTU_ 418 CONJUNTO 3 1796620 Firmicutes Clostridia Clostridiales Ruminococcaceae Acutalibacter Aculalibacter muris -0,51 OTU_ 2640 CONJUNTO 3 342942 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] glycyrrhizinil -yticum -1,00 OTU_ 2555 CONJUNTO 3 1841856 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides mediterraneensis -1,00 OTU_ 1263 SET 3 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis -1.00 OTU_ 1641 SET 3 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 -1.00 OTU_ 884 SET 3 147206 Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella Collinsella stercoris -1.00 OTU_ 2384 SET 3 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes -1.00 OTU_ 620 SET 3 253257 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] amygdalinum -0.64, Petition 870260080213, dated 10 / 08 / 2026, p. 76 / 398 66 / 296 OTU_ 1559 SET 3 817 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides fragilis -0.80 OTU_ 3115 SET 3 47678 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides caccae -0.64 OTU_ 935 SET 3 40545 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Sutterella Sutterella wadsworthensis -1.00 OTU_ 2415 SET 3 645466 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes butyraticus -1.00 OTU_ 876 SET 3 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis -1.00 OTU_ 1027 SET 3 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Ihubacter Ihubacter massiliensis -0.64 OTU_ 2412 SET 3 1532 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia coccoides -1.00 OTU_ 1305 SET 3 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis -1,00 OTU_ 1554 SET 3 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum -1.00 OTU_ 567 SET 3 333367 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] asparagiforme -0.55 OTU_ 815 SET 3 544645 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Butyricimonas Butyricimonas virosa -1.00 OTU_ 1898 SET 3 454154 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Paraprevotella Paraprevotella clara -0.64 OTU_ 1143 SET 3 46503 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides merdae -1.00 OTU_ 3106 SET 3 454154 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Paraprevotella Paraprevotella clara -1.00 OTU_ 576 SET 3 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum -0,59 OTU_ 740 CONJUNTO 3 156456 Firmicutes Negativicutes Veillonellales Veillonellaceae Anaeroglobus Anaeroglobus geminatus -1,00 OTU_ 1827 CONJUNTO 3 470145 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides coprocola DSM 17136 -1,00 OTU_ 3025 CONJUNTO 3 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis -1,00 OTU_ 1709 CONJUNTO 3 46206 Firmicutes Clostridia Clostridiales Lachnospiraceae Pseudobutyrivibrio Pseudobutyrivibrio rummis -1,00 OTU_ 3158 CONJUNTO 3 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis -1,00 OTU_ 2145 CONJUNTO 3 544645 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Butyricimonas Butyricimonas virosa -0,64 OTU_ 3211 CONJUNTO 3 449673 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides stercoris ATCC 43183 -0,64 OTU CONJUNTO 180164 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia -1,00, Petition 870260080213, dated 10 / 08 / 2026, p. 77 / 398 67 / 296 2932 3 schinkii OTU_ 3210 SET 3 1232428 Firmicutes Negativicutes Veillonellales Veillonellaceae Megasphaera Megasphaera massiliensis -0.75 OTU_ 2843 SET 3 449673 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides stercoris ATCC 43183 -0.75 OTU_ 1531 SET 3 1232428 Firmicutes Negativicutes Veillonellales Veillonellaceae Megasphaera Megasphaera massiliensis -1.00 OTU_ 750 SET 3 239935 Verrucomicrobia Verrucomicrobiae Verrucomicrobiales Akkermansiaceae Akkermansia Akkermansia muciniphila -0.55 OTU_ 1801 SET 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -0.80 OTU_ 1621 SET 3 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum -1.00 OTU_ 2179 SET 3 449673 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides stercoris ATCC 43183 -1,00 OTU_ 2121 CONJUNTO 3 1544 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] oroticum -0,64 OTU_ 2070 CONJUNTO 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -1,00 OTU_ 1071 CONJUNTO 3 585528 Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Gardnerella Gardnerella vaginalis ATCC 14018 = JCM 11026 -1,00 OTU_ 767 CONJUNTO 3 33039 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia [Ruminococcus] torques -0,55 OTU_ 2257 CONJUNTO 3 821 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides vulgatus -0,55 OTU_ 2072 CONJUNTO 3 339860 Euryarchacota Methanobacteria Methanobacteriales Methanobacteriaceae Methanosphaera Methanosphaera stadtmanae DSM 3091 -1,00 OTU_ 1321 CONJUNTO 3 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum -1,00 OTU_ 2533 SET 3 308994 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialister Dialister propionificaciens -1.00 OTU_ 1105 SET 3 1796618 Firmicutes Clostridia Clostridiales Lachnospiraceae Cuneatibacter Cuneatibacter caecimuris -0.64 OTU_ 2403 SET 3 824 Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter Campylobacter gracilis -1.00 OTU_ 1934 SET 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -0.55 OTU_ 2553 SET 3 1841856 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides mediterraneensis -1.00 OTU_ 2977 SET 3 40519 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus callidus -1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 78 / 398 68 / 296 OTU_ 2988 SET 3 301302 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia faecis -1.00 OTU_ 3116 SET 3 33025 Firmicutes Negativicutes Acidaminococcales Acidaminococcaceae Phascolarctobacterium Phascolarctobacterium faecium -1.00 OTU_ 3019 SET 3 487175 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasutterella Parasutterella excrementihominis -0.75 OTU_ 2198 SET 3 39496 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium ventriosum -1.00 OTU_ 46 SET 3 199 Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter Campylobacter concisus -0.55 OTU_ 2942 SET 3 871665 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia faecis -0.75 OTU_ 1361 SET 3 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta -0.64 OTU_ 2636 SET 3 1265 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus Flavefaciens -1.00 OTU_ 2285 SET 3 1232428 Firmicutes Negativicutes Veillonellales Veillonellaceae Megasphaera Megasphaera massiliensis -1.00 OTU_ 3094 SET 3 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum -0.75 OTU_ 1358 SET 3 40519 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus callidus -0.64 OTU_ 2259 SET 3 46867 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium chauvoei -0.64 OTU_ 3181 SET 3 218538 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialister Dialister invisus -0.64 OTU_ 2642 SET 3 253257 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] amygdalinum -1,00 OTU_ 2552 SET 3 1236515 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides sartorii JCM 17136 - DSM 21941 -1.00 OTU_ 2556 SET 3 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] clostridioforme -1.00 OTU_ 2636 SET 3 116085 Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus catus -1.00 OTU_ 2943 SET 3 202800 Firmicutes Clostridia Clostridiales Not classified. NA Flavonifractor Flavonifractor plantii -1.00 OTU_ 2989 SET 3 1121115 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia wexlerae DSM 19850 -1.00 OTU_ 2624 SET 3 357276 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides dorei -0.64 OTU_ 2243 SET 3 1096246 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella effluvii -0.64, Petition 870260080213, dated 10 / 08 / 2026, p. 79 / 398 69 / 296 OTU_ 2214 SET 3 1232428 Firmicutes Negativicutes Veillonellales Veillonellaceae Megasphaera Megasphaera massiliensis -0.55 OTU_ 2199 SET 3 454154 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Paraprevotella Paraprevotella clara -0.64 OTU_ 1990 SET 3 537011 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella copri DSM 18205 -1.00 OTU_ 3002 SET 3 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio crossotus -1.00 OTU_ 1596 SET 3 172901 Lentisphaerae Lentisphaeria Victivallales Victivallaceae Victivallis Victivallis vadensis -1.00 OTU_ 1151 SET 3 76517 Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter Campylobacter hominis -1.00 OTU_ 1322 SET 3 168384 Firmicutes Clostridia Clostridiales Lachnospiraceae Marvinbryantia Marvinbryantia formatexigens -1,00 OTU_ 2692 CONJUNTO 3 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis -1,00 OTU_ 3054 CONJUNTO 3 1471761 Firmicutes Bacilli Bacillales Thermoactinomycetaceae Novibacillus Novibacillus thermophilus -1,00 OTU_ 3137 CONJUNTO 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -1,00 OTU_ 2905 CONJUNTO 3 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis -1,00 OTU_ 1783 CONJUNTO 3 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum -1,00 OTU_ 1498 CONJUNTO 3 824 Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter Campylobacter gracilis -1,00 OTU_ 2450 CONJUNTO 3 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi -1,00 OTU_ 3004 SET 3 69825 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] indolis -1.00 OTU_ 95 SET 3 28135 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella oris -0.75 OTU_ 1368 SET 3 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis -1.00 OTU_ 1460 SET 3 381308 Proteobacteria Gammaproteobacteria Chromatiales Thioalkalispiraceae Thiohalophilus Thiohalophilus thiocyanatoxydans -1.00 OTU_ 1488 SET 3 28446 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] propionicum -1,00 OTU_ 1601 SET 3 181487 Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces Actinomyces cardiffensis -1,00 OTU_ 69 SET 3 505 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Kingella Kingella oralis -1,00 OTU_ 2301 SET 3 515620 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium [Eubacterium] eligens ATCC27750 -0.64 OTU SET 113107 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus -0.75, Petition 870260080213, dated 10 / 08 / 2026, p. 80 / 398 70 / 296 1510 3 australis OTU_ 2258 SET 3 871665 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia faecis -0.64 OTU_ 2473 SET 3 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM17042 -1.00 OTU_ 1671 SET 3 40545 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Sutterella Sutterella wadsworthensis -1.00 OTU_ 2545 SET 3 1002367 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella stercorea DSM 18206 -1.00 OTU_ 2620 SET 3 1796636 Firmicutes Clostridia Clostridiales Lachnospiraceae Frisingicoccus Erisingicoccus caecimuris -1.00 OTU_ 2956 SET 3 470145 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides coprocola DSM 17136 -1.00 OTU_ 1598 SET 3 1264 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus albus -1,00 OTU_ 2537 CONJUNTO 3 745368 Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis -1,00 OTU_ 684 CONJUNTO 3 644 Proteobacteria Gammaproteobacteria Aeromonadales Aeromonadaceae Aeromonas Aeromonas hydrophila -1,00 OTU_ 951 CONJUNTO 3 47847 Actinobacteria Actinobacteria Micrococeales Dermabacteraceae Brachybacterium Brachybacterium nesterenkovii -1,00 OTU_ 286 CONJUNTO 3 888828 Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus Haemophilus parainfluenzae ATCC 33392 -0,64 OTU_ 1238 CONJUNTO 3 553973 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] hylemonae DSM15053 -0,75 OTU_ 1135 CONJUNTO 3 638849 Synergistetes Synergistia Synergistales Synergistaceae Pyramidobacter Pyramidobacter piscolens -1,00 OTU_ 1789 CONJUNTO 3 454154 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Paraprevotella Paraprevotella clara -1,00 OTU_ 526 SET 3 470565 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella histicola -0.80 OTU_ 1166 SET 3 28137 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella veroralis -0.64 OTU_ 1281 SET 3 1417852 Firmicutes Clostridia Clostridiales Not classified. NA Flintibacter Flintibacter butyricus -0.64 OTU_ 883 SET 3 1348613 Firmicutes Clostridia Clostridiales Defluviitaleaceae Vallitalea Vallitalea pronyensis -1.00 OTU_ 1445 SET 3 29364 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] polysaccharolyticum -1.00 OTU SET 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotratcus Anaerotruncus -1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 81 / 398 71 / 296 1582 3 colihominis OTU_ 1958 CONJUNTO 3 58134 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Desulfotomaculum] gutioideum -1,00 OTU_ 352 CONJUNTO 3 52693 Firmicutes Clostridia Clostridiales Eubacteriaceae Acetobacterium Acetobacterium paludosum -1.00 OTU_ 941 CONJUNCT 3 425941 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella nanceiensis -1.00 OTU_ 1495 CONJUNCT 3 43675 Actinobacteria Actinobacteria Micrococcales Micrococcaceae Rothia Rothia mucilaginosa -1.00 OTU_ 2172 JOINT 3 187326 Firmicutes Negativicutes Veillonellales Veillonellaceae Megasphaera Megasphaera micronuciformis -1,00 OTU_ 511 CONJUNTO 3 228603 Bacteroidia Bacteroidales Prevotellaceae Prevotellaceae Prevotella Prevotella shahii -1,00 OTU_ 601 CONJUNTO 3 1236516 Bacteroidia Bacteroidales Prevotellaceae Prevotellaceae Prevotella Prevotella saccharolutica JCM 17484 -1,00 OTU_ 1074 SET 3 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobilis -1.00 OTU_ 48 SET 1 717959 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes shahii WAL 8301 1.00 OTU_ 242 SET 1 587 Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Providencia Providencia rettgeri 1.00 OTU_ 194 SET 1 758823 Not classified. NA Not classified. NA Not classified. NA Not classified. NA Vampirovibrio Vampirovibrio chlorellavorus 1.00 OTU_ 262 SET 1 649756 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes hadrus 1.00 OTU_ 1226 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 213 SET 1 671218 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Alloprevotella Alloprevotella rava 1,00 OTU_ 350 SET 1 1264 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus albus 1.00 OTU_ 249 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 477 SET 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1.00 OTU_ 356 SET 1 484018 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides plebeius DSM 17135 1.00 OTU_ 426 SET 1 46503 Bacteroidetes Bacteroidia Bacteroidales Porphyromononadaceae Parabacteroides Parabacteroides merdae 1.00 OTU SET 54565 Proteobacteria Deltaproteo- Desulfovibriona- Desulfovibrionaceae Desulfovibrio Desulfovibrio 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 82 / 398 72 / 296 143 1 bacteria les simplex OTU_ 386 SET 1 290052 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivibrio Acetivibrio ethanolignens 1.00 OTU_ 387 SET 1 216931 Tenericutes Mollicutes Entomoplasmatales Spiroplasmataceae Spiroplasma Spiroplasma alleghenense 1.00 OTU_ 1618 SET 1 575978 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio idahonensis 1.00 OTU_ 380 SET 1 433321 Firmicutes Negativicutes Selenomonadales Selenomonadaceae Propionspira Propionspira arcuata 1.00 OTU_ 359 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 128 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 536 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM 17042 1,00 OTU_ 392 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 499 SET 1 228924 Firmicutes Clostridia Clostridial Clostridial Family XII. Incertae Sedis Guggenheimella Guggenheimella bovis 1.00 OTU_ 264 SET 1 717959 Bacteroidetes Bacteroidea Bacteroidales Rikenellaceae Alistipes Alistipes shahii WAL 8301 1.00 OTU_ 110 SET 1 1796646 Bacteroidetes Bacteroidea Bacteroideles Porphyromonadaceae Muribaculum Intestinal muribaculum 1.00 OTU_ 215 SET 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1.00 OTU_ 484 SET 1 1509 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium sporogenes 1.00 OTU_ 86 SET 1 1462919 Firmicutes Clostridia Clostridiales Lachnospiraceae Mobilitalea Mobilitalea sibirica 1.00 .00 OTU_ 275 SET 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1.00 OTU_ 178 SET 1 337097 Firmicutes Bacilli Bacillales Bacillaceae Vulcanibacillus Vulcanibacillus modesticaldus 1.00 OTU_ 2653 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 1.00 OTU_ 337 SET 1 487174 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Barnesiella Barnesiella intestinihominis 1.00 OTU SET 642492 Firmicutes Clostridia Clostridiales Lachnospiraceae Cellulosilyticum Clostridium 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 83 / 398 73 / 296 530 1 ladocellum DSM 5427 OTU_ 123 SET 1 1735 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Holdemanella Holdemanella biformis 1.00 OTU_ 1846 SET 1 1297424 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerobacterium Anaerobacterium chartisolvens 1.00 OTU_ 134 SET 1 742766 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Dysgonomonas Dysgonomonas gadei ATCC BAA - 286 1.00 OTU_ 654 SET 1 1462919 Firmicutes Clostridia Clostridiales Lachnospiraceae Mobilitalea Mobilitalea sibirica 1.00 OTU_ 621 SET 1 46680 Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Methylobacillus Pseudomonas nitroreducens 1.00 OTU_ 233 SET 1 132925 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium bowmanii 1.00 OTU_ 271 SET 1 758823 Not classified. NA Not classified. NA Not classified. NA Not classified.NA Vampirovibrio Vampirovibrio chlorellavorus 1.00 OTU_ 561 SET 1 411467 Firmicutes Clostridia Clostridiales Not classified. NA Pseudoflavonifractor Pseudoflavonifractor capillosus ATCC 29799 1.00 OTU_ 687 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 707 SET 1 1318465 Tenericutes Mollicutes Acholeplasmatales Acholeplasmataceae Acholeplasma Acholeplasma brassicae 0502 1.00 OTU_ 1950 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII.Incertae Sedis Ihubacter Ihubacter massiliensis 1.00 OTU_ 1113 SET 1 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis 1.00 OTU_ 344 SET 1 169679 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium saccharobutylicum 1.00 OTU_ 529 SET 1 1175296 Euryarchaeota Thermoplasmata Methanomassiliicoccales Methanomassiliicoccaceae Methanomassiliicoccus Methanomassili icoccus luminyensis B10 1.00 OTU_ 58 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 2607 SET 1 259063 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerocolumna Anaerocolumna jejuensis 1.00 OTU_ 542 SET 1 172901 Lentisphaerae Lentisphaeria Victivallaies Victivallaceae Victivallis Victivallis vadensis 1.00 OTU SET 39488 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium [Eubacterium] 1.00. Petition 870260080213, dated 10 / 08 / 2026, p. 84 / 398 74 / 296 724 1 hallii OTU_ 473 SET 1 57172 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfotomaculum Desulfotomaculum halophilum 1.00 OTU_ 2146 SET 1 28118 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Odoribacter Odoribacter splanchnicus 1.00 OTU_ 793 SET 1 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis 1.00 OTU_ 90 SET 1 28133 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella nigrescens 1.00 OTU_ 593 SET 1 758823 No Classified. NA Not classified. NA Not classified. NA Not classified.NA Vampirovibrio Vampirovibrio chlorellavorus 1.00 OTU_ 504 SET 1 1529 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium cadaveris 1.00 OTU_ 322 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 524 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1.00 OTU_ 805 SET 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter ruminantium GH1 1.00 OTU_ 798 SET 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] sacchiarolyyticum 1.00 OTU_ 300 SET 1 56774 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Not classified.NA [Eubacterium] infirmum 1.00 OTU_ 617 SET 1 102148 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Solobacterium Solobacterium moorei 1.00 OTU_ 156 SET 1 626947 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasutterella Parasutterella secunda 1.00 OTU_ 1449 SET 1 1297424 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerobacterium Anaerobacterium chartisolvens 1.00 OTU_ 109 SET 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1.00 OTU_ 1622 SET 1 216933 Tenericutes Mollicutes Entomoplasmatales Spiroplasmataceae Spiroplasma Spiroplasma chrysopicola 1.00 OTU_ 205 SET 1 626947 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasutterella Parasutterella secunda 1.00 OTU_ 306 SET 1 758823 Não clasificado. NA Not classified. NA Not classified. NA Not classified.NA Vampirovibrio Vampirovibrio chlorellavorus 1.00 OTU_ 206 SET 1 1348613 Firmicutes Clostridia Clostridiales Defluviitaleaceae Vallitalea Vallitalea pronyensis 1.00. Petition 870260080213, of 10 / 08 / 2026, p. 85 / 398 75 / 296 OTU_ 2657 CONJUNTO 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1,00 OTU_ 2102 CONJUNTO 1 1472417 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Butyricimonas Butyricimonas paravirosa 1,00 OTU_ 329 CONJUNTO 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1,00 OTU_ 1499 CONJUNTO 1 824 Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter Campylobacter gracilis 1,00 OTU_ 756 CONJUNTO 1 1471761 Firmicutes Bacilli Bacillales Thermoactinomycetaceae Novibacillus Novibacillus thermophilus 1,00 OTU_ 634 CONJUNTO 1 1297617 Firmicutes Clostridia Clostridiales Não clasificado. NA Intestinimonas Intestinimonas butyriciproducens 1,00 OTU_ 374 CONJUNTO 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophiia 1,00 OTU_ 527 SET 1 1317125 Bacteroidetes Cytophagia Cytophagaies Hymenobacteraceae Pontibacter Pontibacter indicus 1.00 OTU_ 772 SET 1 28197 Proteobacteria Ensilonproteobacteria Campylobacterales Campylobacteraceae Arcobacter Arcobacter butzleri 1.00 OTU_ 2652 SET 1 358743 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] citoniae 1.00 OTU_ 1352 SET 1 642492 Firmicutes Clostridia Clostridiales Lachnospiraceae Cellulosilyticum Clostridium lentocellum DSM 5427 1.00 OTU_ 678 SET 1 264639 Tenericutes Mollicutes Acholeplasmatales Acholeplasmataceae Acholeplasma Acholeplasma parvum 1.00 OTU_ 468 SET 1 1265 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus Flavefaciens 1.00 OTU_ 775 SET 1 1122135 Proteobacteria Alphaproteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1,00 OTU_ 1526 SET 1 1335 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus equinus 1.00 OTU_ 2951 SET 1 66219 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium Lachnoclostridium phytofermentans 1.00 OTU_ 953 SET 1 69473 Tenericutes Mollicutes Acholeplasmatales Acholeplasmataceae Acholeplasma Acholeplasma vituli 1.00 OTU_ 431 SET 1 115117 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio desulfuricans subsp. desulfuricans 1.00 OTU_ 1952 SET 1 341220 Firmicutes Clostridia Clostridiales Clostridiaceae Lactonifactor Lactonifactor longoviformis 1.00 OTU_ 599 SET 1 758823 Not classified. NA Not classified. NA Not classified. NA Not classified. NA Vampirovibrio Vampirovibrio chlorellavorus 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 86 / 398 76 / 296 OTU_ 362 SET 1 1732 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium oxidoreducens 1.00 OTU_ 340 SET 1 873513 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella buccae ATCC 33574 1.00 OTU_ 1032 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 2116 SET 1 411467 Firmicutes Clostridia Clostridiales Não clasido. NA. Porphyromonadaceae Barnesiella Barnesiella intestinihominis 0.55 OTU_ 2458 SET 1 396504 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiciostridium [Clostridium] sufflavum 1,00 OTU_ 1020 SET 1 1796619 Firmicutes Clostridia Clostridiales Eubacteriaceae Irregularibacter Irregularibacter muris 1.00 OTU_ 967 SET 1 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis 1.00 OTU_ 2801 SET 1 45851 Firmicutes Clostridia Clostridiales Clostridiaceae Butyrivibrio Butyrivibrio crossotus 1.00 OTU_ 942 SET 1 1509 Firmicutes Clostridia Clostridiales Lachnospiraceae Clostridium Clostridium sporogenes 1.00 OTU_ 2995 SET 1 259063 Firmicutes Clostridia Clostridiales Peptococcaceae Anaerocolumna Anaerocolumna jejuensis 1.00 OTU_ 865 SET 1 2741 Firmicutes Clostridia Clostridiales Peptococcaceae Peptococcus Peptococcus niger 1.00 OTU_ 1158 SET 1 105841 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes caccae 1.00 OTU_ 1693 SET 1 86332 Firmicutes Clostridia Clostridiales Clostridiales Family XII Incertae Sedis Mogibacterium Mogibacterium pumilum 1,00 OTU_ 236 SET 1 1349822 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Coprobacter Coprobacter fastidiosus NSB1 1.00 OTU_ 2554 SET 1 84037 Firmicutes Clostridia Clostridiales Lachnospiraceae Syntrophococcus Syntrophococcus sucromutans 1.00 OTU_ 558 SET 1 180311 Firmicutes Clostridia Clostridiales Lachnospiraceae Hespellia Hespellia stercorisuis 1.00 OTU_ 223 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaccae Sporobacter Sporobacter termitidis 0.59 OTU_ 925 SET 1 54291 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Raoultella Raoultella ornithinolyt- 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 87 / 398 77 / 296 ica OTU_ 1965 SET 1 1509 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium sporogenes 1.00 OTU_ 608 SET 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1.00 OTU_ 836 SET 1 1217282 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides faecis 1.00 OTU_ 862 SET 1 172901 Lentisphaerae Lentisphaeria Victivallales Victivallaceae Victivallis Victivallis vadensis 1.00 OTU_ 227 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1.00 OTU_ 185 SET 1 762984 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides clarus YIT 12056 1.00 OTU_ 406 SET 1 1185412 Firmicutes Clostridia Clostridiales Defluviitaleaceae Vallitalea Vallitalea guaymasensis 1,00 OTU_ 479 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1.00 OTU_ 127 SET 1 1122135 Proteobacteria Alphaproteobacterium SET 1 1122135 Proteobacteria Kiloniellales Kiloniellaceae Kiloniella Kiloniella laminariae DSM 19542 1.00 OTU_ 1344 SET 1 663278 Firmicutes Clostridia Clostridiales Ruminococcaceae Ethanoligenes Ethanoligenes harbinense YUAN-3 1.00 OTU_ 136 SET 1 1543 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium oceanicum 0.65 OTU_ 1050 SET 1 626947 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasutterella Parasutterella secunda 1.00 OTU_ 995 SET 1 398512 Firmicutes Clostridia Clostridiales Ruminococcaceae Pseudobacteroids Pseudobacteroids cellulosolvens ATCC 35603 = DSM 2933 1.00 OTU_ 2543 SET 1 1297424 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerobacterium Anaerobacterium chartisolvens 1.00.00 OTU_ 2983 SET 1 1335 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus equinus 1.00 OTU_ 1869 SET 1 587 Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Providencia Providencia rettgeri 1.00 OTU_ 190 SET 1 66219 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium Lachnoclostridium phytofermentans 1.00 OTU_ 1714 SET 1 69825 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] indolis 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 88 / 398 78 / 296 OTU_ 657 SE 117529 Euryarchaeota Thermoplasmata Methanomassiliicoccales Methanomassiliicoccaceae Methanomassiliicoccus Methanomassili -icoccus luminyensis B10 1.00 OTU_ 957 SET 1 1841867 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1.00 OTU_ 346 SET 1 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Raminiclostridium [Clostridium] leptum 1.00 OTU_ 1979 SET 1 1265 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus Flavefaciens 1.00 OTU_ 2606 SET 1 1510 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] stercorarium 1.00 OTU_ 989 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU_ 2820 SET 1 1502 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium perfringens 1,00 OTU_ 1434 CONJUNTO 1 1297424 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerobacterium Anaerobacterium chartisolvens 1,00 OTU_ 596 CONJUNTO 1 1619234 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerobium Anaerobium acetethylicum 1,00 OTU_ 1447 CONJUNTO 1 398512 Firmicutes Clostridia Clostridiales Ruminococcaceae Pseudobacteroides Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933 1,00 OTU_ 2980 CONJUNTO 1 1335 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus equinus 1,00 OTU_ 1848 CONJUNTO 1 39497 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium xylanophilum 1,00 OTU_ 1802 CONJUNTO 1 1544 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] oroticum 1,00 OTU_ 2171 CONJUNTO 1 873513 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella buccae ATCC 33574 1,00 OTU_ 1141 SET 1 29343 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] cellulosi 1.00 OTU_ 83 SET 1 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio crossotus 1.00 OTU_ 627 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans 1.00 OTU_ 3010 SET 1 56774 Firmicutes Clostridia Clostridiales Clostridiales Family XIII Incertae Sedis Not classified.NA [Eubacterium] infirmum 1.00 OTU_ 1055 SET 1 1732 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium oxidoreducens 1.00 OTU_ 2647 SET 1 649762 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia luti DSM 14534 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 89 / 398 79 / 296 OTU_ 1230 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1.00 OTU_ 1549 SET 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1.00 OTU_ 1985 SET 1 332095 Firmicutes Tissierellia Not classified.NA Not classified.NA Dethiosulfatibacter Dethiosulfatib acter aminovorans 1.00 OTU_ 1040 SET 1 536633 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia glucerasea 1.00 OTU_ 404 SET 1 1033731 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes timonensis JC136 1.00 OTU_ 722 SET 1 1297617 Firmicutes Clostridia Clostridiales Not classified. NA Intestinimonas Intestinimonas butyriciproducens 1.00 OTU_ 173 SET 1 574930 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides gordonii 0.55 OTU_ 932 CONJUNTO 1 742818 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Slackia Slackia piriformis YIT 12062 1,00 OTU_ 1296 CONJUNTO 1 1264 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus albus 1,00 OTU_ 801 CONJUNTO 1 177412 Verrucomicrobia Verrucomicrobiae Verrucomicrobiales Verrucomicrobiaceae Fucophilus Fucophilus fucoidanolyticus 1,00 OTU_ 1320 CONJUNTO 1 1121308 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Clostridioides Clostridioides difflcile ATCC 9689 = DSM 1296 0,50 OTU_ 2930 CONJUNTO 1 419208 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella denticariosi 1,00 OTU_ 503 CONJUNTO 1 1673717 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaeromassilibacillus Anaeromassilibacillus senegalensis 1,00 OTU_ 708 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 129 SET 1 180311 Firmicutes Clostridia Clostridiales Lachnospiraceae Hespellia Hespellia stercorisuis 0.59 OTU_ 385 SET 1 55779 Firmiutes Clostridia Thermoanaerobacterales Thermoanaerobacteraceae Moorella Moorella glycerini 0.55 OTU_ 279 SET 1 28117 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes putredinis 1.00 OTU_ 1489 SET 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenellella Christensenell a minuta 1.00 OTU_ 1237 SET 1 180332 Firmicutes Clostridia Clostridiales Lachnospiraceae Robinsoniella Robinsoniella peoriensis 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 90 / 398 80 / 296 OTU_ 1951 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM 17042 1.00 OTU_ 2662 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 3108 SET 1 40519 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus callidus 1.00 OTU_ 1201 SET 1 34062 Proteobacteria Gammaproteobacteria Pseudomonadales Moraxellaceae Moraxella Moraxella osloensis 1.00 OTU_ 551 SET 1 40518 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus bromii 1.00 OTU_ 1077 SET 1 74426 Actinobacteria Coriobacteria Coriobacteriales Coriobacteriaceae Collinsella Collinsella aerofaciens 1.00 OTU_ 1126 SET 1 1216062 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfotomaculum Desulfotomaculum tongense 1,00 OTU_ 1138 CONJUNTO 1 293826 Firmicutes Clostridia Clostridiales Clostridiaceae Alkaliphilus Alkaliphilus metalliredigens QYMF 1,00 OTU_ 952 CONJUNTO 1 1619234 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerobium Anaerobium acetethylicum 1,00 OTU_ 2954 CONJUNTO 1 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio crossotus 1,00 OTU_ 1721 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 1084 CONJUNTO 1 850 Fusobacteria Fusobacteria Fusobacteriales Fusobacteriaceae Fusobacterium Fusobacterium mortiferum 1,00 OTU_ 106 CONJUNTO 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 0,50 OTU_ 1013 CONJUNTO 1 645466 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes butyraticus 1,00 OTU_ 1345 CONJUNTO 1 474960 Firmicutes Clostridia Clostridiales Ruminococcaceae Hydrogenoanaerobacterium Hydrogenoanaerobacterium saccharovorans 1,00 OTU_ 1775 CONJUNTO 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] saccharolyticum 1,00 OTU_ 666 CONJUNTO 1 36835 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] colinum 1,00 OTU_ 1602 CONJUNTO 1 115544 Firmicutes Clostridia Clostridiales Lachnospiraceae Parasporobacterium Parasporobacterium paucivorans 1,00 OTU_ 550 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00 OTU_ 851 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 91 / 398 81 / 296 OTU_ 1982 CONJUNTO 1 88431 Firmicutes Clostridia Clostridiales Lachnospiraceae Dorea Dorea longicatena 1,00 OTU_ 486 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00 OTU_ 1024 CONJUNTO 1 216932 Tenericutes Mollicutes Entomoplasmatales Spiroplasmataceae Spiroplasma Spiroplasma chinense 1,00 OTU_ 1262 CONJUNTO 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1,00 OTU_ 382 CONJUNTO 1 1417852 Firmicutes Clostridia Clostridiales Não clasificado.NA Flintibacter Flintibacter butyricus 0,73 OTU_ 472 CONJUNTO 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1,00 OTU_ 1076 CONJUNTO 1 39492 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Eubacterium] siraeum 1,00 OTU_ 686 CONJUNTO 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1,00 OTU_ 458 CONJUNTO 1 1583 Firmicutes Bacilli Lactobacillales Leuconostocaceae Weissella Weissella confusa 1,00 OTU_ 449 CONJUNTO 1 663278 Firmicutes Clostridia Clostridiales Ruminococcaceae Ethanoligenens Ethanoligenens harbinense YUAN-3 1,00 OTU_ 555 CONJUNTO 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1,00 OTU_ 1623 CONJUNTO 1 1297617 Firmicutes Clostridia Clostridiales Não clasificado.NA Intestinimonas Intestinimonas butyriciproducens 1,00 OTU_ 703 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00 OTU_ 347 CONJUNTO 1 420247 Euryarchaeota Methanobacteria Methanobacteriales Methanobacteriaceae Methanobrevibacter Methanobrevibacter smithii ATCC 35061 0,55 OTU_ 1139 CONJUNTO 1 118967 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Anaerorhabdus Anaerorhabdus furcosa 1,00 OTU_ 1407 CONJUNTO 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1,00 OTU_ 1414 CONJUNTO 1 37658 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] populeti 1,00 OTU_ 791 CONJUNTO 1 138595 Actinobacteria Coriobacteriia Coriobacteriales Atopobiaceae Olsenella Olsenella profusa 1,00 OTU_ 1246 CONJUNTO 1 31971 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Não clasificado.NA [Eubacterium] dolichum 1.00 OTU SET 100886 Firmicutes Erysipelo- Erysipelotricha- Erysipelotrichaceae Catenibacterium Cateni- 1.00. Petition 870260080213, of 10 / 08 / 2026, p. 92 / 398 82 / 296 216 1 trichia les bacterium mitsuokai OTU_ 1147 SET 1 1197717 Synergistetes Synergistia Synergistales Synergistaceae Cloacibacillus Cloacibacillus porcorum 1.00 OTU_ 733 SET 1 234908 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Sutterella Sutterella stercoricanis 1.00 OTU_ 2095 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 659 SET 1 2741 Firmicutes Clostridia Clostridiales Peptococcaceae Peptococcus Peptococcus niger 1.00 OTU_ 757 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Uncertain Locations Ihubacter Ihubacter massiliensis 1.00 OTU_ 2678 SET 1 1417852 Firmicutes Clostridia Clostridiales Not classified.AND Flintibacter Flintibacter butyricus 1.00 OTU_ 1477 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 0.68 OTU_ 1402 SET 1 762984 Bacteroidetes Bacteroidia Bacteroideae Bacteroidaceae Bacteroides Bacteroides clarus YIT 12056 1.00 OTU_ 2277 SET 1 537007 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia hansenii DSM 20583 1.00 OTU_ 2566 SET 1 487174 Bacteroidetes Bacteroidea Bacteroidales Porphyromonadaceae Banresiella Banresiella intestinihominis 1.00 OTU_ 2119 SET 1 1732 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium oxidoreducens 1.00 OTU_ 1039 SET 1 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum 1.00 OTU_ 1603 SET 1 228924 Firmicutes Clostridia Clostridiales Clostridiales Family XII.Uncertain Sites Guggenheimella Guggenheimella bovis 1.00 OTU_ 2669 SET 1 319644 Firmicutes Clostridia Clostridiales Ruminococcaceae Saccharofermentans Saccharofermentans acetigenes 1.00 OTU_ 2044 SET 1 168384 Firmicutes Clostridia Clostridiales Lachnospiraceae Marvinbryantia Marvinbryantia formatexigens 1.00 OTU_ 411 SET 1 915173 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Faecalicoccus Faecalicoccus acidiformans 1.00 OTU_ 357 SET 1 95159 Firmicutes Clostridia Clostridiales Clostridiaceae Caloramator Caloramator coolhaasii 0.68 OTU_ 1616 SET 1 31971 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Não clasido. NA [Eubacterium] dolichum 1.00 OTU_ 541 SET 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1.00 OTU SET 1816678 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christen- 1.00. Petition 870260080213, dated 10 / 08 / 2026, p. 93 / 398 83 / 296 1737 1 senella timonensis OTU_ 2707 CONJUNTO 1 1417852 Firmicutes Clostridia Clostridiales Não clasificado. NA Flintibacter Flintibacter butyricus 1.00 OTU_ 255 SET 1 626940 Firmicutes Negativicutes Acidaminococcales Acidaminococcaceae Phascolarcbacterium Phascolarctobacterium succinatutens 1.00 OTU_ 1901 SET 1 501571 Firmicutes Clostridia Clostridiales Clostridiaceae Butyricicoccus Butyricicoccus pullicaecorum 0.50 OTU_ 3081 SET 1 1796620 Firmicutes Clostridia Clostridiales Ruminococcaceae Acutalibacter Acutalibacter muris 1.00 OTU_ 2902 SET 1 888727 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Not classified. NA Eubacterium sulci ATCC 35585 1.00 OTU_ 2418 SET 1 1147123 Firmicutes Clostridia Clostridiales Clostridiaceae Caloramator Caloramator quimbayensis 1.00 OTU_ 2936 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 100 OTU_ 1244 SET 1 376806 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides gallinarum 0.55 OTU_ 1333 SET 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1.00 OTU_ 1340 SET 1 1274356 Firmicutes Bacilli Bacillales Thermoactinomycetac eae Kroppenstedtia Kroppenstedtia guangzhouensis 1.00 OTU_ 900 SET 1 1267 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium ventriculi 1.00 OTU_ 1684 SET 1 1335 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus equinus 1.00 OTU_ 3012 SET 1 39495 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium uniforme 1,00 OTU_ 3013 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM 17042 1,00 OTU_ 1300 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00 OTU_ 912 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Ihubacter Ihubacter massiliensis 1.00 OTU_ 786 SET 1 404403 Firmicutes Clostridia Clostridiales Not classified. NA Howardella Howardella ureilytica 1.00 OTU_ 1277 SET 1 1348 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus parauberis 1.00 OTU_ 1617 SET 1 172901 Lentisphaerae Lentisphaeria Victivallales Victivallaceae Victivallis Victivallis vadensis 1.00 OTU SET 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 94 / 398 84 / 296 1994 1 crossotus OTU_ 1850 SET 1 253314 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] straminisolvens 1.00 OTU_ 2802 SET 1 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio crossotus 1.00 OTU_ 581 SET 1 1796619 Firmicutes Clostridia Clostridiales Eubacteriaceae Irregularibacter Irregularibacter muris 1.00 OTU_ 1747 SET 1 258515 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetanaerobacterium Acetanaerobacterium elongatum 0.50 OTU_ 2428 SET 1 1297617 Firmicutes Clostridia Clostridiales No classified. NA Intestinimonas Intestinimonas butyriciproducens 1.00 OTU_ 157 SET 1 33033 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Parvimonas Parvimonas micra 1.00 OTU_ 630 SET 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter ruminantium GH1 0,55 OTU_ 1366 CONJUNTO 1 1297617 Firmicutes Clostridia Clostridiales Não clasificado. NA Intestinimonas Intestinimonas butyriciproducens 1,00 OTU_ 1247 CONJUNTO 1 649762 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia luti DSM14534 1,00 OTU_ 1590 CONJUNTO 1 1118061 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes obesi 1,00 OTU_ 3014 CONJUNTO 1 357276 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides dorei 1,00 OTU_ 489 CONJUNTO 1 214851 Firmicutes Clostridia Clostridiales Ruminococcaceae Subdoligranulum Subdoligranulum variabile 0,50 OTU_ 1311 CONJUNTO 1 320502 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] alkalicellulosi 1,00 OTU_ 1389 CONJUNTO 1 217731 Tenericutes Mollicutes Entomoplasmatales Entomoplasmataceae Mesoplasma Mesoplasma photuris 1,00 OTU_ 1086 CONJUNTO 1 246787 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides cellulosilyticus 0,59 OTU_ 1131 SET 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1.00 OTU_ 704 SET 1 1841867 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1.00 OTU_ 710 SET 1 29371 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] termitidis 1.00 OTU_ 2810 CONJUNTO 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] saccharolyticum 1.00 Petition 870260080213, dated 10 / 08 / 2026, p. 95 / 398 85 / 296 OTU_ 921 SET 1 649764 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Slackia Slackia exigua ATCC 700122 1.00 OTU_ 1159 SET 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1.00 OTU_ 2583 SET 1 901 Proteobacteria Deltaproteobaciena Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio piger 1.00 OTU_ 1767 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 984 SET 1 29374 Firmicutes Clostridia Clostridiales Peptostreptococcaeeae Filifactor Filifactor villosus 1.00 OTU_ 1065 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 1763 SET 1 29343 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] cellulosi 1.00 OTU_ 1768 SET 1 33043 Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus eutactus 1,00 OTU_ 1525 CONJUNTO 1 39778 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella dispar 1,00 OTU_ 2860 CONJUNTO 1 39778 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella dispar 1,00 OTU_ 2297 CONJUNTO 1 86332 Firmicutes Clostridia Clostridiales Clostridiales Família XIII. Incertae Sedis Mogibacterium Mogibacterium pumilum 1,00 OTU_ 842 CONJUNTO 1 682400 Firmicutes Clostridia Clostridiales Não clasificado. NA Natranaerovirga Natranaerovirga pectinivora 0.55 OTU_ 1567 JOINT 1 871665 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia faecis 1.00 OTU_ 1774 JOINT 1 160404 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] lactatifermentans 1,00 OTU_ 974 CONJUNTO 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1,00 OTU_ 1578 SET 1 396504 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] sufflavum 1.00 OTU_ 1196 SET 1 214851 Firmicutes Clostridia Clostridiales Ruminococcaceae Subdoligranulum Subdoligranulum variabile 0.5 OTU_ 1680 SET 1 1502 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium perfringens 1.00 OTU_ 562 SET 1 40519 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus callidus 1.00 OTU_ 1455 SET 1 745368 Firmicutes Clostridia Clostridiales Ruminococcaceae Gemmiger Gemmiger formicilis 1.00 OTU_ 2413 COMBINED 1 408 Proteobacteria Alphaproteobacteria Rhizobiales Methylobacteriaceae Methylobacterium Methylobacterium extorquens 1.00 OTU COMBINED 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] 1.00 Petition 870260080213, dated 10 / 08 / 2026, p. 96 / 398 86 / 296 575 1 leptum OTU_ 294 CONJUNTO 1 1584 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus delbrueckii 1,00 OTU_ 1362 CONJUNTO 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophila 1,00 OTU_ 1931 CONJUNTO 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1,00 OTU_ 1619 CONJUNTO 1 1510 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] stercorarium 1,00 OTU_ 779 CONJUNTO 1 333367 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] asparagiforme 1,00 OTU_ 1119 CONJUNTO 1 47246 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] viride 1,00 OTU_ 731 CONJUNTO 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 0,59 OTU_ 403 SET 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter ruminantium GH1 0.55 OTU_ 1279 SET 1 47246 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] viride 1.00 OTU_ 1514 SET 1 1096246 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella effluvii 1.00 OTU_ 1992 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1.00 OTU_ 2248 SET 1 290052 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivirium Acetivibrium ethanolgignens 1.00 OTU_ 2668 SET 1 642492 Firmicutes Clostridia Clostridiales Lachnospiraceae Cellulosilyticum Clostridium lentocellum DSM 5427 1.00 OTU_ 631 SET 1 53342 Firmicutes Clostridia Clostridiales Clostridiaceae Coloramator Coloramator proteoclasticus 0.00.63 OTU_ 1998 CONJUNTO 1 54291 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Raoultella Raoultella ornithinolytica 1,00 OTU_ 1031 CONJUNTO 1 438033 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus gauvreauii 1,00 OTU_ 2991 CONJUNTO 1 351091 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter valericigenes 0,55 OTU_ 2032 CONJUNTO 1 1796622 Firmicutes Clostridia Clostridiales Lachnospiraceae Extibacter Extibacter muris 1,00 OTU_ 2641 CONJUNTO 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1,00 OTU_ 1657 CONJUNTO 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 0,55 OTU_ 880 CONJUNTO 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 97 / 398 87 / 296 JW / YJL-S1 OTU_ 405 SET 1 1776384 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Emergence Emergence timonensis 0.50 OTU_ 809 SET 1 39492 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Eubacterium] siraeum 1.00 OTU_ 2167 SET 1 817 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacieroids Bacteroides fragilis 1.00 OTU_ 2670 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU_ 2671 SET 1 1417852 Firmicutes Clostridia Clostridiales Not classified. NA Flintibacter Flintibacter butyricus 1.00 OTU_ 1056 SET 1 411467 Firmicutes Clostridia Clostridiales Não clasificado. NA Pseudoflavonifractor Pseudoflavonifractor capillosus ATCC 29799 1.00 OTU_ 1597 CONJUNTO 1 1776384 Firmicutes Clostridia Clostridiales Clostridiales Família XIII. Incerta Sedis Emergencia Emergencia timonensis 1,00 OTU_ 739 CONJUNTO 1 48256 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] hungatei 1,00 OTU_ 894 CONJUNTO 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1,00 OTU_ 961 CONJUNTO 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1,00 OTU_ 820 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00 OTU_ 1466 CONJUNTO 1 1796620 Firmicutes Clostridia Clostridiales Ruminococcaceae Acutalibacter Acutalibacter muris 1,00 OTU_ 1741 CONJUNTO 1 720554 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] clariflavum DSM 19732 1,00 OTU_ 1984 CONJUNTO 1 1007096 Firmicutes Clostridia Clostridiales Osciliospiraceae Oscillibacter Oscillibacter ruminantium GH1 1,00 OTU_ 2004 SET 1 47246 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] viride 1.00 OTU_ 2005 SET 1 500632 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella Tyzzerella nexilis DSM 1787 1.00 OTU_ 2655 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 1548 SET 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1.00 OTU SET 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 98 / 398 88 / 296 1307 1 timonensis OTU_ 1329 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1.00 OTU_ 1081 SET 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1.00 OTU_ 2028 SET 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1.00 OTU_ 1766 SET 1 36849 Firmicutes Clostridia Clostridiales Clostridiaceae Oxobacter Oxobacter pfennigii 1.00 OTU_ 2219 SET 1 301302 Firmicutes Clostridia Clostridials Lachnospiraceae Roseburia Roseburia faecis 1.00 OTU_ 2117 SET 1 879970 Firmicutes Clostridia Clostridiales Defluviitaleaceae Defluviitalea Defluviitalea saccharophila 1.00 OTU_ 410 SET 1 655811 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Anaerococcus Anaerococcus vaginalis ATCC51170 1,00 OTU_ 1411 CONJUNTO 1 1096246 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella effluvii 1,00 OTU_ 2567 CONJUNTO 1 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobilis 1,00 OTU_ 864 CONJUNTO 1 1532 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia coccoides 1,00 OTU_ 2001 CONJUNTO 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1,00 OTU_ 1535 CONJUNTO 1 285 Proteobacteria Betaproteobact eria Burkholderiales Comamonadaceae Comamonas Comamonas testosteroni 1,00 OTU_ 2111 CONJUNTO 1 995 Bacteroidetes Sphingobacteri ia Sphingobacteriales Sphingobacteriaceae Solitalea Solitalea canadensis 1,00 OTU_ 978 CONJUNTO 1 242750 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella bergensis 1,00 OTU_ 765 CONJUNTO 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter ruminantium GH1 1,00 OTU_ 2419 CONJUNTO 1 29539 Actinobacteria Thermoleophili a Thermoleophilales Thermoleophilaceae Thermoleophilum Thermoleophilum album 1,00 OTU_ 2853 CONJUNTO 1 1432052 Firmicutes Clostridia Clostridiales Lachnospiraceae Eisenbergiella Eisenbergiella tayi 1,00 OTU_ 1220 CONJUNTO 1 1673717 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaeromassilibacillus Anaeromassilibacillus senegalensis 1,00 OTU_ 850 CONJUNTO 1 168384 Firmicutes Clostridia Clostridiales Lachnospiraceae Marvinbryantia Marvinbryantia formatexigens 1,00 OTU_ 777 CONJUNTO 1 39492 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Eubacterium] siraeum 0,50 OTU_ 713 CONJUNTO 1 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum 0,63, Petição 870260080213, de 10 / 08 / 2026, pág. 99 / 398 89 / 296 OTU_ 2973 SET 1 622312 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia inulinivorans DSM16841 1.00 OTU_ 1324 SET 1 36849 Firmicutes Clostridia Clostridiales Clostridiaceae Oxobacter Oxobacter pfennigii 1.00 OTU_ 1061 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU_ 3167 SET 1 622312 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia inulinivorans DSM16841 0.72 OTU_ 1337 SET 1 1796636 Firmicutes Clostridia Clostridiales Lachnospiraceae Frisingicoccus Frisingicoccus caecimuris 1.00 OTU_ 2731 SET 1 214851 Firmicutes Clostridia Clostridiales Ruminococcaceae Subdoligranulum Subdoligranulum variabile 1.00 OTU_ 2654 SET 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1.00 OTU_ 2807 SET 1 1337051 Firmicutes Clostridia Clostridiales Lachnospiraceae Murimonas Murimonas intestini 1,00 OTU_ 3041 SET 1 328814 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes shahii 0.65 OTU_ 1861 SET 1 28446 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] propionicum 1.00 OTU_ 1726 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 2618 SET 1 1796620 Firmicutes Clostridia Clostridiales Ruminococcaceae Acutalibacter Acutalibacter muris 1.00 OTU_ 2484 SET 1 1492 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium butyricum 1.00 OTU_ 1378 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1.00 OTU_ 2645 SET 1 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis 1.00 OTU_ 1258 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM17042 1,00 OTU_ 1829 TOGETHER 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1.00 OTU_ 1999 TOGETHER 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 2796 TOGETHER 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1.00 OTU_ 2614 SET 1 39496 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium ventriosum 1.00 OTU_ 522 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus The pineapple trunk of the man 0.55, Petition 870260080213, dated 10 / 08 / 2026, p. 100 / 398 90 / 296 OTU_ 2071 CONJUNTO 1 52786 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerofilum Anaerofilum agile 1,00 OTU_ 1859 CONJUNTO 1 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum 1,00 OTU_ 2913 CONJUNTO 1 39492 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Eubacterium] siraeum 1,00 OTU_ 3126 CONJUNTO 1 39497 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium xylanophilum 1,00 OTU_ 2123 CONJUNTO 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1,00 OTU_ 2676 CONJUNTO 1 1549 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] sporosphaeroides 1,00 OTU_ 2118 CONJUNTO 1 1796618 Firmicutes Clostridia Clostridiales Lachnospiraceae Cuneatibacter Cunealibacter caecimuris 1,00 OTU_ 1091 CONJUNTO 1 582 Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Morganella Morganella morganii 1,00 OTU_ 1800 SET 1 160404 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] lactatifermentons 1.00 OTU_ 1190 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM 17042 1.00 OTU_ 2220 SET 1 40519 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus callidus 1.00 OTU_ 373 SET 1 46507 Firmicutes Tissierellia Não clasido. NA Not classified. NA Not classified. NA [Bacteroides] coagulans 1.00 OTU_ 1094 SET 1 694434 Firmicutes Clostridia Clostridiales Gracilibacteraceae Gracilibacter Gracilibacter thermotolerans JW / YJL-S1 1.00 OTU_ 1473 SET 1 109327 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Anaerovorax Anaerovorax odorimutans 1.00 OTU_ 2273 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] closiridioforme 1,00 OTU_ 210 CONJUNTO 1 1382 Actinobacteria Coriobacteriia Coriobacteriales Alopobiaceae Atopobium Atopobium parvuium 1,00 OTU_ 2632 CONJUNTO 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 0,75 OTU_ 2850 CONJUNTO 1 33039 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia [Ruminococcus] torques 1,00 OTU_ 2808 CONJUNTO 1 1432052 Firmicutes Clostridia Clostridiales Lachnospiraceae Eisenbergiella Eisenbergiella tayi 1,00 OTU_ 754 CONJUNTO 1 311460 Firmicutes Bacilli Bacillales Bacillaceae Anoxybacillus Anoxybacillus rupiensis 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 101 / 398 91 / 296 OTU_ 1278 SET 1 1264 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus albus 1.00 OTU_ 972 SET 1 582 Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Morganella Morganella morganii 0.50 OTU_ 3152 SET 1 301302 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia faecis 1.00 OTU_ 177 SET 1 230143 Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Scardovia Scardovia wiggsiae 1.00 OTU_ 802 SET 1 216935 Tenericutes Mollicutes Entomoplasmatales Spiroplasmataceae Spiroplasma Spiroplasma culicicola 1.00 OTU_ 445 SET 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1.00 OTU_ 1973 SET 1 1337051 Firmicutes Clostridia Clostridiales Lachnospiraceae Murimonas Murimonas intestini 1.00 OTU_ 1650 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 1782 SET 1 539 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Eikenella Eikenella corrodens 1.00 OTU_ 310 SET 1 35519 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Mogibacterium Mogibacterium timidum 1.00 OTU_ 2045 SET 1 1681 Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium bifidum 1.00 OTU_ 3178 SET 1 328813 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes onderdonkii 1.00 OTU_ 1468 SET 1 214853 Firmicutes Clostridia Clostridiales Eubacteriaceae Anaerofustis Anaerofustis stercorihominis 1.00 OTU_ 2798 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathawayi 1.00 OTU_ 799 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1,00 OTU_ 1365 SET 1 39495 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium uniforme 1.00 OTU_ 1773 SET 1 1297617 Firmicutes Clostridia Clostridiales Não clasido. NA Intestinimonas Intestinimonas butyriciproducens 1.00 OTU_ 3011 SET 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1.00 OTU_ 1433 SET 1 109327 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Uncertain Location Anaerovorax Anaerovorax odorimutans 1.00 OTU_ 1863 SET 1 89014 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia luti 1.00 OTU SET 33043 Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 102 / 398 92 / 296 2270 1 eutactus OTU_ 2596 SET 1 216933 Tenericutes Mollicutes Entomoplasmatales Spironlasmataceae Spiroplasma Spiroplasma chrysopicola 1.00 OTU_ 826 SET 1 537007 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia hansenii DSM 20583 1.00 OTU_ 2844 SET 1 1121115 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia wexlerae DSM 19850 0.55 OTU_ 2120 SET 1 1585974 Firmicutes Clostridia Clostridiales Clostridiaceae Beduini Beduini massiliensis 1.00 OTU_ 2927 SET 1 29466 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella parvula 1.00 OTU_ 2750 SET 1 290052 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivibrio Acetivibrio ethanolignens 1.00 OTU_ 2621 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1,00 OTU_ 1996 SET 1 1363 Firmicutes Bacilli Lactobacillales Streptococcaceae Lactococcus Lactococcus garvieae 1,00 OTU_ 1877 SET 1 54291 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Raoultella Raoultella ornithinolytica 1.00 OTU_ 3051 SET 1 411467 Firmicutes Clostridia Clostridiales Not classified. NA Pseudoflavonifractor Pseudoflavonifactor capillosus ATCC 29799 1.00 OTU_ 2033 SET 1 292800 Firmicutes Clostridia Clostridiales Not classified. NA Flavonifractor Flavonifractor plantii 1.00 OTU_ 2000 SET 1 270498 Firmicutes Clostridia Clostridiales Catabacteriaceae Catabacter Catabacter hongkongensis 1.00 OTU_ 945 SET 1 214856 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes flnegoldii 0.70 OTU_ 1636 SET 1 142877 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfltobacterium Desulfltobacterium metallireducens 1.00 OTU_ 2027 SET 1 341220 Firmicutes Clostridia Clostridiales Clostridiaceae Lactonifactor Lactonifactor longaviformis 1,00 OTU_ 3205 SET 1 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis 1.00 OTU_ 1174 SET 1 109327 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Anaerovorax Anaerovorax odorimutans 1.00 OTU_ 1866 SET 1 133926 Adinobacteria Coriobacteriia Coriobacteriales Atopobiaceae Olsenella Olsenella uli 1.00 OTU_ 2265 SET 1 1583 Firmicutes Bacilli Lactobacillales Leuconostocaceae Weissella Weissella confusa 1.00 OTU SET 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 103 / 398 93 / 296 2518 1 methylpentosum OTU_ 2874 SET 1 209880 Firmicutes Negativicutes Veillonellales Veillonellaceae Allisonella Allisonella histaminiformans 1.00 OTU_ 2877 SET 1 179628 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium colicanis 1.00 OTU_ 3077 SET 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1.00 OTU_ 980 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 1101 SET 1 1510 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] stercorarium 1.00 OTU_ 1962 SET 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] saccharolyticum 1.00 OTU_ 2309 SET 1 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis 0,50 OTU_ 2282 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] clostridioforme 1.00 OTU_ 2151 SET 1 1544 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] oroticum 1.00 OTU_ 1068 SET 1 2741 Firmicutes Clostridia Clostridiales Peptococcaceae Peptococcus Peptococcus niger 1.00 OTU_ 2427 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM17042 1.00 OTU_ 1148 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 0.55 OTU_ 919 SET 1 1297424 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerobacterium Anaerobacterium chartisolvens 1.00 OTU_ 1222 SET 1 871665 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia faecis 0.63 OTU_ 2569 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 1049 CONJUNTO 1 1673717 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaeromassilibacill us Anaeromassilibacillus senegalensis 1,00 OTU_ 1496 CONJUNTO 1 54291 Proteobacteria Gammaproteobac teria Enterobacterales Enterobacteriaceae Raoultella Raoultella ornithinolytica 1,00 OTU_ 948 CONJUNTO 1 28446 Firmicuttes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] propionicum 1,00 OTU_ 914 CONJUNTO 1 112110 Proteobacteria Epsilonproteob acteria Campylobacterale s Campylobacteraceae Campylobacter Campylobacter ureolyticus DSM20703 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 104 / 398 94 / 296 OTU_ 1342 SET 1 69473 Tenericutes Mollicutes Acholeplasmatales Acholeplasmataceae Acholeplasma Acholeplasma vituli 1.00 OTU_ 2210 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 1.00 OTU_ 1706 SET 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacier ruminantium CRU 1.00 OTU_ 2656 SET 1 105612 Firmicutes Bacilli Lactobacillales Lactobaciliaceae Lactobacillus Lactobacillus algidus 1.00 OTU_ 909 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Uncertain Locations Ihubacter Ihubacter massiliensis 1.00 OTU_ 1964 SET 1 1796615 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia caecimuris 1.00 OTU_ 1234 SET 1 39492 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Eubacterium] siraeum 1,00 OTU_ 501 SET 1 682400 Firmicutes Clostridia Clostridiales Não clasificado. NA Natranaerovirga Natranaerovirg a pectinivora 1.00 OTU_ 2939 SET 1 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis 1.00 OTU_ 556 SET 1 39777 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella atypica 0.63 OTU_ 1023 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 0.50 OTU_ 1198 SET 1 1417852 Firmicutes Clostridia Clostridiales Não clasificado. NA Flintibacter Flintibacter butyricus 1.00 OTU_ 2650 SET 1 56774 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Not classified. NA [Eubacterium] infirmum 1.00 OTU_ 1338 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 2434 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 1.00 OTU_ 1197 SET 1 29353 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] aldrichii 1.00 OTU_ 433 SET 1 1579 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus acidophilus 1.00 OTU_ 394 SET 1 163665 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Dysgonomonas Dysgonomonas mossii 1.00 OTU_ 2748 SET 1 47246 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] green 1.00 OTU_ 2251 SET 1 53443 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia hydrogenotrophica 1.00 OTU_ 1272 SET 1 261299 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Intestinibacter Intestinibacter 0.59, Petition 870260080213, dated 10 / 08 / 2026, p. 105 / 398 95 / 296 bartlettii OTU_ 1388 SET 1 1302 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus gordonii 1.00 OTU_ 2677 SET 1 1150298 Firmicutes Clostridia Clostridiales Lachnospiraceae Fusicatenibacter Fusicatenibacter saccharivorans 1.00 OTU_ 464 SET 1 938289 Firmicutes Clostridia Clostridial Unclassified. NA Levyella Levyella massiliensis 1.00 OTU_ 1462 SET 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophila 1.00 OTU_ 1871 SET 1 292800 Firmicutes Clostridia Clostridiales No classified. NA Flavonifractor Flavonifractor plautii 1.00 OTU_ 1649 SET 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophila 1.00 OTU_ 2063 SET 1 328814 Bacteroidetes Bacteroidea Bacteroidales Rikenellaceae Alistipes Alistipes shahii 1.00 OTU_ 2525 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00.00 OTU_ 2422 SET 1 1852367 Firmicutes Clostridia Clostridial Clostridial Family XIII. Incertae Sedis Ihubacter Ihubacter massiliensis 1.00 OTU_ 1697 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 3061 SET 1 53342 Firmicutes Clostridia Clostridiales Clostridiaceae Caloramator Caloramator proteoclasticus 1.00 OTU_ 2213 SET 1 358742 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] aldenense 1.00 OTU_ 1302 SET 1 48256 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] hungatei 1.00 OTU_ 811 SET 1 55779 Firmicutes Clostridia Thermoanaerobacterae Thermoauaerobacteraceae Moorella Moorella giycerini 0.55 OTU_ 3114 SET 1 762984 Bacteroidetes Bacteroidea Bacteroideles Bacteroidaceae Bacteroides Bacteroides clarus YIT 12056 1,00 OTU_ 2828 CONJUNTO 1 471875 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus lactaris ATCC29176 1,00 OTU_ 2542 CONJUNTO 1 258515 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetanaerobacteriurn Acetanaerobacterium elongatum 1,00 OTU_ 3143 CONJUNTO 1 53443 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia hydrogenotrophica 1,00 OTU_ 2311 CONJUNTO 1 817 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides fragilis 1,00 OTU_ 1588 CONJUNTO 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 106 / 398 96 / 296 OTU_ 1881 SET 1 214853 Firmicutes Clostridia Clostridiales Eubacteriaceae Anaerofustis Anaerofustis stercorihominis 1.00 OTU_ 1924 SET 1 1007096 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter ruminantium GH1 1.00 OTU_ 2816 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella HUngatella hathawayi 1.00 OTU_ 534 SET 1 938278 Firmicutes Clostridia Clostridiales Clostridiales Family XIII Incertae Sedis Casaltella Casaltella massiliensis 1.00 OTU_ 2825 SET 1 1796613 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides caecimuris 0.68 OTU_ 2142 SET 1 341220 Firmicutes Clostridia Clostridiales Clostridiaceae Lactonifactor Lactonifactor longoviformis 1.00 OTU_ 1605 SET 1 1841867 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1,00 OTU_ 377 SET 1 1118057 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Peptoniphilus Peptoniphilus grossensis ph5 0.50 OTU_ 315 SET 1 1077144 Actinobacteria Actinobacteria Crynebacteriales Dietziceae Dietzia Dietzia food 72 1.00 OTU_ 2544 SET 1 1737 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Paeniclistridium [Eubacterium] tenuous 1.00 OTU_ 2858 SET 1 1121308 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Clostridioides Clostridioides difficile ATCC 9689 = DSM 1296 1.00 OTU_ 557 SET 1 1796646 Bacteroidetes Bacteroidea Bacteroidales Porphyromonadaceae Muribaculum Intestinal Muribaculum 1.00 OTU_ . 1059 SET 1 411467 Firmicutes Clostridia Clostridiales Unclassified.NA Pseudoflavonifractor Pseudoflavonifractor capillosus ATCC 29799 1.00 OTU_ 2020 SET 1 218205 Firmicutes Clostridia Clostridiales Eubacteriaceae Garciella Garciella nitratereducens 1,00 OTU_ 931 CONJUNTO 1 1121298 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium amylolyticum 1,00 OTU_ 1695 CONJUNTO 1 684066 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus lactarius 1,00 OTU_ 1981 CONJUNTO 1 258515 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetanaerobacterium Acetanaerobacterium elongatum 1,00 OTU_ 2600 CONJUNTO 1 649756 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes hadrus 1,00 OTU_ 1887 CONJUNTO 1 433659 Actinobacteria Actinobacteria Prpionibacteriales Nocardioidaceae Nocardioides Nocardioides mesophilus 1,00 OTU CONJUNTO 52699 Actinobacteria Actinobacteria Prpionibacteria- Nocardioidaceae Aeromicrobium Aeromicrobium 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 107 / 398 97 / 296 2058 1 les fastidiosum OTU_ 2235 SET 1 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis 1.00 OTU_ 1005 SET 1 234908 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Sutterella Sutterella stercoricanis 1.00 OTU_ 1910 SET 1 706562 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus rogosae 0.55 OTU_ 3085 SET 1 253257 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] amygdalinum 0.50 OTU_ 1583 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 2308 SET 1 39496 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium ventriosum 1,00 OTU_ 643 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridia] methylpentosum 0,65 OTU_ 1191 CONJUNTO 1 115544 Firmicutes Clostridia Clostridiales Lachnospiraceae Parasporobacterium Parasporobacterium paucivorans 1,00 OTU_ 1997 CONJUNTO 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] saccharolyticum 1,00 OTU_ 3166 CONJUNTO 1 706562 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus rogosae 0,68 OTU_ 1406 CONJUNTO 1 501571 Firmicutes Clostridia Clostridiales Clostridiaceae Butyricicoccus Butyricicoccus pullicaecorum 1,00 OTU_ 3047 CONJUNTO 1 1509 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium sporogenes 1,00 OTU_ 2916 CONJUNTO 1 328812 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides goldsteinii 0,59 OTU_ 276 CONJUNTO 1 1280 Firmicutes Bacilli Baciilales Staphylocoecaceae Staphylococcus Staphylococcus aureus 0,50 OTU_ 2864 SET 1 1121115 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia wexlerae DSM 19850 1.00 OTU_ 3131 SET 1 762984 Bacteroidetes Bacteroidea Bacteroidales Bacteroidaceae Bacteroides Bacteroides clarus YIT 12056 1.00 OTU_ 414 SET 1 147802 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus iners 1.00 OTU_ 790 SET 1 58134 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Desulfotomaculum] guttoideum 1.00 OTU_ 891 SET 1 1335613 Actinobacteria Coriobacteria Eggerthellales Eggertheliaceae Gordonibacter Gordonibacter urolithinfaciens 1.00 OTU_ 2009 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] clostridioform 0.63. Petition 870260080213, 8 / 10 / 2026, p. 108 / 3 98 / 2 e OTU_ 1870 SET 1 745368 Firmicutes Clostridia Clostridiales Ruminococcaceae Treasurer Treasurer formicilis 0.50 OTU_ 1175 SET 1 52786 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerophilum Anaerophilum agile 1.00 OTU_ 1395 SET 1 328814 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes shahii 0.63 OTU_ 1236 SET 1 891 Proteobacteria Deltaproteobacteria Desulfuromonadales Desulfuromonadaceae Desulfuromonas Desulfuromonas acetoxidans 1.00 OTU_ 2197 SET 1 585394 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia hominis A2-183 1.00 OTU_ 487 SET 1 1582 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus casei 1.00 OTU_ 964 SET 1 235931 Firmicutes Clostridia Clostridiales Eubacteriaceae Alkalibacter Alkalibacter saccharofermentans 1.00 OTU_ 3184 SET 1 308994 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialyzers Dialyzers propionicifaciens 1,1.00 OTU_ 226 SET 1 29466 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella parvula 1.00 OTU_ 1037 SET 1 1589 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus pentosus 1.00 OTU_ 1021 SET 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1.00 OTU_ 1288 SET 1 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobilis 1.00 OTU_ 2276 SET 1 1682 Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifldobacterium longum subsp. infantis 1.00 OTU_ 695 SET 1 1736 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium limosum 1.00 OTU_ 111 ​​SET 1 28129 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella denticola 1.00 OTU_ 1899 SET 1 301302 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia faecis 1,00 OTU_ 2162 CONJUNTO 1 160404 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] laclatifermentans 1,00 OTU_ 1053 CONJUNTO 1 178001 Firmicutes Bacilli Lactobacillales Leuconostocaceae Leuconostoc Leuconostoc inhae 1,00 OTU_ 2698 CONJUNTO 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1,00 OTU_ 934 CONJUNTO 1 1509 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium sporogenes 1,00 OTU_ 1194 CONJUNTO 1 551788 Firmicutes Clostridia Clostridiales Caldicoprobacteraceae Caldicoprobacter Caldicoprobacter oshimai 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 109 / 398 99 / 296 OTU_ 1580 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU_ 645 SET 1 2051 Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Mobiluncus Mobiluncus curtisii 1.00 OTU_ 1319 SET 1 856 Fusobacteria Fusobacteria Fusobacteriales Fusobacteriaceae Fusobacterium Fusobacterium varium 1.00 OTU_ 1738 SET 1 118562 Cyanobacteria Não clasificado. NA Oscillatoriales Microcoleaceae Arthrospira Arthrospira platensis 1.00 OTU_ 2168 SET 1 214856 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes flnegoldii 1.00 OTU_ 1503 SET 1 1302 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus gordonii 1.00 OTU_ 1185 SET 1 292800 Firmicutes Clostridia Clostridiales Não clasido. NA Flavonifractor Flavonifractor plautii 1.00 OTU_ 2365 CONJUNTO 1 101070 Firmicutes Bacilli Bacillales Pianococcaceae Rummeliibacillus Rummeliibacillus pycnus 1,00 OTU_ 1822 SET 1 515619 Firmicutes Clostridia Clostridiales Lachnospiraceae Myxococcus [Rectal Eubacterium] ATCC 33656 0.55 OTU_ 463 SET 1 40215 Proteobacteria Gammaproteobacteria Pseudomonads Moraxeliaceae Acinetobacter Acinetobacter j unii 1.00 OTU_ 3029 SET 1 745368 Firmicutes Clostridia Clostridiales Ruminococcaceae Treasurer Treasurer formicilis 1.00 OTU_ 2649 SET 1 187979 Firmicutes Negativicutes Selenomonadales Selenomonadaceae Mitsuokeiia Mitsuokella j aialudinii 1.00 OTU_ 2666 SET 1 82979 Proteobacteria Gammaproteobacteria Enterobacteria Budviciaceae Budvicia Budvicia aquatica 1.00 OTU_ 2895 SET Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1.00 OTU_ 3020 SET 1 29363 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium paraputriflcum 1.00 OTU_ 3163 SET Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] lactatifermentans 1, 1999;00 OTU_ 1357 SET 1 1776391 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Romboutsia Romboutsia timonensis 1.00 OTU_ 1550 SET 1 1285191 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfotomaculum Desulfotomaculum intricatum 1.00 OTU_ 2275 SET 1 84112 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Eggerthella Eggerthella longa 1.00 OTU_ 1828 SET 1 46503 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides medoe 1.00 OTU_ 1647 SET 1 157688 Fusobacteria Fusobacteriia Fusobacteriales Leptotrichiaceae Leptotrichia Leptotrichia hofstadii 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 110 / 398 100 / 296 OTU_ 425 SET 1 38304 Actinobacteria Actinobacteria Corynebacteriales Corynebacteriaceae Corynebacterium Corynebacterium tuberculostearicum 1.00 OTU_ 3121 SET 1 1096246 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella effluvii 1.00 OTU_ 2982 SET 1 105841 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes caccae 1.00 OTU_ 2929 SET 1 292800 Firmicutes Clostridia Clostridiales Não clasificado. NA Flavonifractor Flavonifractor plautii 1.00 OTU_ 2019 SET 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1.00 OTU_ 508 SET 1 1417852 Firmicutes Clostridia Clostridiales Not classified. NA Flintibacter Flintibacter butyricus 1.00 OTU_ 1664 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII Incertae Sedis Ihubacter Ihubacter massiliensis 1,00 OTU_ 1854 CONJUNTO 1 259063 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerocolumna Anaerocolumna jejuensis 1,00 OTU_ 2847 CONJUNTO 1 36850 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium quinii 1,00 OTU_ 3191 CONJUNTO 1 341694 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Peptostreptococcus Peptostreptococcus stomatis 1,00 OTU_ 3208 CONJUNTO 1 287 Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa 1,00 OTU2 2253 CONJUNTO 1 75612 Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Porphyromonas Pseudomonas mandelii 1,00 OTU_ 2511 CONJUNTO 1 901 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio piger 1,00 OTU_ 2002 CONJUNTO 1 1417852 Firmicutes Clostridia Clostridiales Não clasificado. NA Flintibacter Flintibacter butyricus 1,00 OTU_ 2524 SET 1 818 Bacteroidetes Bacteroidea Bacteroideae Bacteroidaceae Bacteroides Bacteroides thetaiotaomicron 1.00 OTU_ 2530 SET 1 371674 Firmicutes Clostridia Clostridiales Lachnospiraceae Moryella Moryella indoligenes 1.00 OTU_ 2536 SET 1 338188 Bacteroidetes Bacteroidea Bacteroidales Bacteroidaceae Bacteroides Bacteroides flnegoldii 1.00 OTU_ 2608 SET 1 69825 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] indolis 1.00 OTU_ 568 SET 1 88164 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus fornicalis 1.00 OTU_ 2872 SET 1 1121115 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia wexlerae DSM 19850 1.00 OTU SET 588581 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] 1.00. Petition 870260080213, 8 / 10 / 2026, p. 111 / 3 101 / 2 816 1 papyrosolvens DSM 2782 OTU_ 1060 CONJUNTO 1 351091 Firmicutes Clostridia Clostridiales Oscillospiraceae Oscillibacter Oscillibacter valericigenes 1,00 OTU_ 1193 CONJUNTO 1 676965 Firmicutes Clostridia Themoanaerobacterales Thermoanaerobaeteraceae Moorella Moorella humiferrea 1,00 OTU_ 1639 CONJUNTO 1 358742 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] aldenense 1,00 OTU_ 1727 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 221 CONJUNTO 1 546271 Firmicutes Negativicutes Selenomonadales Selenomonadaceae Selenomonas Selenomonas sputigena ATCC35185 1,00 OTU_ 2468 CONJUNTO 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1,00 OTU_ 3057 CONJUNTO 1 47246 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] viride 1,00 OTU_ 3093 SET 1 123651-7 Bacteroidetes Bacteroidea Bacteroideles Bacteroidaceae Bacteroides Bacteroides rodentium JCM 16496 1.00 OTU_ 3098 SET 1 40518 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus bromii 1.00 OTU_ 732 SET 1 1318465 Tenericutes Mollicutes Acholeplasmatales Acholeplasmataceae Acholeplasma Acholeplasma brassicae 0502 1.00 OTU_ 837 SET 1 178338 Firmicutes Tissierellia Not classified. NA Not classified. NA Sedimentibacter Sedimentibacter hongkongensis 1.00 OTU_ 871 SET 1 154046 Firmicutes Clostridia Clostridiales Clostridiaceae Hungatella Hungatella hathewayi 1.00 OTU_ 923 SET 1 328813 Bacteroidetes Bacteroidea Bacteroidales Rikenellaceae Alistipes Alistipes onderdonkii 1.00 OTU_ 991 SET 1 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobilis 1.00.00 OTU_ 768 SET 1 862517 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Peptoniphilus Peptoniphilus duerdemi ATCCBAA-1640 1.00 OTU_ 1251 SET 1 157687 Fusobacteria Fusobacteria Fusobacteriales Leptotrichiaceae Leptotrichia Leptotrichia wadei 1.00 OTU_ 160 SET 1 158 Spirochaetes Spirochaetia Spirochaetales Spirochaetaceae Treponema Treponema denticola 1.00 OTU_ 1633 SET 1 1841867 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1.00 OTU_ 2294 SET 1 29466 Firmicutes Negativicutes Veilloneliales Veillonellaceae Veillonella Veillonella little 1.00 OTU_ 2993 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU SET 51048 Proteobacteria Gammaproteo- Pasteurellales Pasteurellaceae Actinobacillus Actinobacillus 1.00 Petition 870260080213, dated 10 / 08 / 2026, p. 112 / 398 102 / 296 926 1 bacteria porcinus OTU_ 16 SET 1 1583331 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas pasteri 1.00 OTU_ 1170 SET 1 411467 Firmicutes Clostridia Clostridiales Não clasido. NA Pseudoflavonifractor Pseudoflavonifractor capillosus ATCC 29799 1.00 OTU_ 1566 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00 OTU_ 863 SET 1 529 Proteobacteria Alphaproteobacteria Rhizobiales Brucellaceae Ochrobactrum Ochrobactrum anthropi 1.00 OTU_ 3206 SET 1 1349822 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Coprobacter Coprobacter fastidiosus NSB1 1.00 OTU_ 1518 SET 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophila 1.00 OTU_ 1678 SET 1 901 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio lazy 1,00 OTU_ 2086 CONJUNTO 1 290052 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivibrio Acetivibrio ethanolgignens 1,00 OTU_ 2560 CONJUNTO 1 1535 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] leptum 1,00 OTU_ 2976 CONJUNTO 1 536633 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia glucerasea 1,00 OTU_ 3190 CONJUNTO 1 706562 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus rogosae 1,00 OTU_ 3195 CONJUNTO 1 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis 1,00 OTU_ 625 CONJUNTO 1 888745 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus agalactiae ATCC 13813 1,00 OTU_ 1063 CONJUNTO 1 214851 Firmicutes Clostridia Clostridiales Ruminococcaceae Subdoligranulum Subdoligranulum variabile 1,00 OTU_ 1865 CONJUNTO 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1,00 OTU_ 1926 SET 1 1732 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium oxidoreducens 1.00 OTU_ 3050 SET 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacier Papillibacier cinnamivorans 1.00 OTU_ 993 SET 1 308994 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialister Dialister propionificaciens 1.00 OTU_ 2923 SET 1 89014 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia luti 0.59 OTU_ 3040 SET 1 357276 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides dorei 0.55 OTU_ 2300 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 113 / 398 103 / 296 OTU_ 940 CONJUNTO 1 394340 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Asaccharobacter Asaccharobacter celatus 0,55 OTU_ 1116 CONJUNTO 1 40545 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Sutterella Sutterella wadsworthensis 1,00 OTU_ 1442 CONJUNTO 1 184186 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1,00 OTU_ 1656 CONJUNTO 1 855 Fusobacteria Fusobacteria Fusobacteriales Fusobacteriaceae Fusobacterium Fusobacterium simiae 1,00 OTU_ 2376 CONJUNTO 1 357276 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides dorei 1,00 OTU_ 2538 CONJUNTO 1 515619 Firmicutes Clostridia Clostridiales Lachnospiraceae Myxococcus [Eubacterium rectale] ATCC 33656 1,00 OTU_ 2602 CONJUNTO 1 1619234 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerobium Anaerobium acetethylicum 1,00 OTU_ 2603 SET 1 553973 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] hylemonae DSM15053 1.00 OTU_ 2604 SET 1 213810 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus champanellensis 18P13 = JCM 17042 1.00 OTU_ 1658 SET 1 253257 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] amygdalinum 1.00 OTU_ 1188 SET 1 938293 Firmicutes Tissierellia Tissierellales Peptoniphiiaceae Anaerococcus Anaerococcus provenciensis 1.00 OTU_ 1374 SET 1 93063 Proteobacteria Alphaproteobacteria Sphingomonadales Sphingomonadaceae Sphingomonas Sphingomonas aquatilis 1.00 OTU_ 1558 SET 1 1796646 Bacteroidetes Bacteroidea Bacteroidales Porphyromonadaceae Muribaculum Intestinal Muribaculum 1.00 OTU_ 2232 SET 1 708634 Proteobacteria Betaproteobactcria Burkholderiales Unclassified. NA Aquabacterium Aquabacterium limnoticum 1,100.00 OTU_ 2563 SET 1 179995 Proteobacteria Gammaproteobacteria Aeromonadales Succinivibrionaceae Atiaerobiospirillum Anaerobiospirillum thomasii 1.00 OTU_ 745 SET 1 35519 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Mogibacterium Mogibacterium timidum 1.00 OTU_ 1506 SET 1 1351 Firmicutes Bacilli Lactobacillales Enterococcaceae Enterococcus Enterococcus faecalis 1.00 OTU_ 1114 SET 1 476652 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfosporosinus Desulfosporosinus acididurans 1.00 OTU_ 2029 SET 1 1417852 Firmicutes Clostridia Clostridiales Not classified. NA Flintibacter Flintibacter butyricus 1.00 OTU_ 439 SET 1 1464038 Firmicutes Tissierellia Não clasificado. NA Not classified. NA Ezakielia Ezakiella peruensis 1.00 OTU_ 1638 SET 1 555088 Firmicutes Clostridia Clostridiales Syntrophomonadaceae Dethiobacter Dethiobacter alkaliphilus. 1.00 Petition 870260080213, dated 10 / 08 / 2026, p. 114 / 398 104 / 296 AHT 1 OTU_ 1740 SET 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1.00 OTU_ 1725 SET 1 1841867 Firmicutes Clostridia Clostridiales Ruminococcaceae Phocea Phocea massiliensis 1.00 OTU_ 2319 SET 1 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis 1.00 OTU_ 2322 SET 1 237576 Firmicutes Clostridia Clostridiales Lachnospiraceae Oribacterium Oribacterium sinus 1.00 OTU_ 1301 SET 1 1776382 Firmicutes Clostridia Clostridiales Ruminococcaceae Neglecta Neglecta timonensis 1.00 OTU_ 1328 SET 1 358742 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] aldenense 1.00 OTU_ 1579 SET 1 1515 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium Ruminiclostridium thermocellum 1.00 OTU_ 1889 SET 1 879566 Firmicutes Clostridia Clostridiales Lachnospiraceae Acetatifactor Acetatifactor muris 1,00 OTU_ 2460 SET 1 1852371 Actinobacteria Choriobacteria Eggerthellales Eggerthellaceae Raoultibacter Raoultibacter massiliensis 1.00 OTU_ 830 SET 1 404403 Firmicutes Clostridia Clostridiales Unclassified. NA Howardella Howardella ureilytica 1.00 OTU_ 1173 SET 1 1852367 Firmicutes Clostridia Clostridiales Clostridiales Family XIII Incertae Sedis Ihubacter Ihubacter massiliensis 1.00 OTU_ 2007 SET 1 253314 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] straminisolvens 1.00 OTU_ 1836 SET 1 328814 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes shahii 1.00 OTU_ 2353 SET 1 742727 Bacteroidetes Bacteroidea Bacteroideles Bacteroidaceae Bacteroides Bacteroides oleiciplenus YIT 12058 0.50 OTU_ 1178 SET 1 253314 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] straminisolvens 1.50.00 OTU_ 1463 SET 1 626937 Firmicutes Clostridia Clostridiales Christensenellaceae Christensenella Christensenella minuta 1.00 OTU_ 1977 SET 1 1377 Firmicutes Bacilli Lactobacillales Aerococcaceae Aerococcus Aerococcus viridans 1.00 OTU_ 2610 SET 1 588581 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] papyrosolvens DSM 2782 1.00 OTU_ 2611 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] closiridioforme 1.00 OTU_ 2612 SET 1 35830 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivibrio Acetivibrio cellulolytic 1, Petition 870260080213, dated 10 / 08 / 2026, p. 115 / 398 105 / 296 OTU_ 2615 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1.00 OTU_ 2619 SET 1 100176 Firmicutes Clostridia Clostridiales Ruminococcaceae Papillibacter Papillibacter cinnamivorans 1.00 OTU_ 2799 SET 1 626947 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasuttereila Parasutterella secundo 1.00 OTU_ 3001 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 1.00 OTU_ 3036 SET 1 438033 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus gauvreauii 1.00 OTU_ 726 SET 1 1732 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium oxidoreducens 1.00 OTU_ 138 SET 1 997353 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella pallens ATCC 700821 1,00 OTU_ 1325 SET 1 1432052 Firmicutes Clostridia Clostridiales Lachnospiraceae Eisenbergiella Eisenbergiella tayi 1.00 OTU_ 1561 SET 1 649756 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerostipes Anaerostipes hadrus 1.00 OTU_ 512 SET 1 33043 Firmicutes Clostridia Clostridiales Lachnospiraceae Coprococcus Coprococcus eutactus 0.50 OTU_ 2968 SET 1 218538 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialister Dialister invisus 1.00 OTU_ 1308 SET 1 214856 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes flnegoldii 1.00 OTU_ 1057 SET 1 83771 Proteobacteria Gammaproteobacteria Aeromonadales Succinivibrionaceae Succinivibrio Succinivibrio dextrinosolvens 1.00 OTU_ 1547 SET 1 671218 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Ailoprevotella Alloprevotella rava 1.00 OTU_ 2298 SET 1 1605 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus animalis 1,00 OTU_ 2915 CONJUNTO 1 28111 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides eggerthii 1,00 OTU_ 461 CONJUNTO 1 131109 Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces Actinomyces bowdenii 1,00 OTU_ 959 CONJUNTO 1 1302 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus gordonii 1,00 OTU_ 2069 CONJUNTO 1 46609 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium pascui 1,00 OTU_ 3092 CONJUNTO 1 1297617 Firmicutes Clostridia Clostridiales Não clasificado. NA Intestinimonas Intestinimonas butyriciproducens 1,00 OTU_ 1371 CONJUNTO 1 690567 Firmicutes Clostridia Clostridiales Syntrophomonadaceae Syntrophomonas Syntrophomonas zehnderi OL-4 1,00 OTU_ 2008 CONJUNTO 1 46206 Firmicutes Clostridia Clostridiales Lachnospiraceae Pseudobutyrivibrio Pseudobutyrivibrio 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 116 / 398 106 / 296 rummis OTU_ 874 CONJUNTO 1 155615 Fusobacteria Fusobacteria Fusobacteriales Fusobacteriaceae Fusobacterium Fusobacterium nucleatum subsp. vincentii 0,5 OTU_ 1382 CONJUNTO 1 333367 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] asparagiforme 1,00 OTU_ 2065 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 1569 CONJUNTO 1 51616 Firmicutes Clostridia Clostridiales Peptococcaceae Desulfitobacterium Desulfitobacterium chlororespirans 1,00 OTU_ 2838 CONJUNTO 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 0,50 OTU_ 1890 CONJUNTO 1 1796620 Firmicutes Clostridia Clostridiales Ruminococcaceae Acutalibacter Acutalibacter muris 1,00 OTU_ 112 CONJUNTO 1 40542 Fusobacteria Fusobacteriales Fusobacteriales Leptotrichiaceae Leptotrichia Leptotrichia buccalis 1,00 OTU_ 2136 SET 1 396504 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] sufflavum 1.00 OTU_ 1280 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotuncus Anaerotuncus colihominis 1.00 OTU_ 88 SET 1 203 Proteobacteria Epsilouproteob acteria Campylobacterales Campylobactera-ceae Campylobacter Campylobacter rectus 1.00 OTU_ 3193 SET 1 328814 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes shahii 1.00 OTU_ 810 SET 1 294 Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas fluorescens 1.00 OTU_ 2803 SET 1 411467 Firmicutes Clostridia Clostridiales Not classified. NA Pseudoflavonifractor Pseudoflavonifractor capillosus ATCC 29799 1.00 OTU_ 2813 SET 1 1605 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus animalis 1,00 OTU_ 3096 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00 OTU_ 2955 SET 1 1034346 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Dielma Dielma fastidiosa 1.00 OTU_ 395 SET 1 156456 Firmicutes Negativicutes Veillonellales Veillonellaceae Anaeroclobus Anaeroclobus geminatus 1.00 OTU_ 3097 SET 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1.00 OTU_ 819 SET 1 80866 Proteobacteria Betaproteobacteria Burkholderiales Comamonadaceae Delftia Delftia acidovorans 1.00 OTU_ 1299 SET 1 358742 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] aldenense 0.59, Petition 870260080213, dated 10 / 08 / 2026, p. 117 / 398 107 / 296 OTU_ 3058 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 915 CONJUNTO 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1,00 OTU_ 2561 CONJUNTO 1 44749 Firmicutes Clostridia Clostridiales Ruminococcaceae Sporobacter Sporobacter termitidis 1,00 OTU_ 1857 CONJUNTO 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 887 CONJUNTO 1 84030 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] saccharolyticum 1,00 OTU_ 1593 CONJUNTO 1 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobilis 1,00 OTU_ 2096 CONJUNTO 1 820 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides uniformis 1,00 OTU_ 1572 CONJUNTO 1 169435 Firmicutes Clostridia Clostridiales Ruminococcaceae Anaerotruncus Anaerotruncus colihominis 1,00 OTU_ 2402 CONJUNTO 1 853 Firmicutes Clostridia Clostridiales Ruminococcaceae Faecalibacterium Faecalibacterium prausnitzii 1,00 OTU_ 64 CONJUNTO 1 554406 Fusobacteria Fusobacteria Fusobacteriales Leptotrichiaceae Leptotrichia Leptotrichia hongkongensis 1,00 OTU_ 1306 CONJUNTO 1 290054 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium Eubacterium coprostanoligenes 1,00 OTU_ 197 CONJUNTO 1 796942 Firmicutes Clostridia Clostridiales Lachnospiraceae Stomatobaculum Stomatobaculum longum 1,00 OTU_ 2572 CONJUNTO 1 1605 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus animalis 1,00 OTU_ 296 CONJUNTO 1 1002367 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella stercorea DSM 18206 0,55 OTU_ 1711 SET 1 29347 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] scindens 1.00 OTU_ 254 SET 1 796944 Firmicutes Clostridia Clostridiales Lachnospiraceae Oribacterium Oribacterium asaccharolyticum ACB7 1.00 OTU_ 139 SET 1 61592 Actinobacteria Actinobacteria Corynebacteriales Corynebacteriaceae Corynebacterium Corynebacterium durum 1.00 OTU_ 1332 SET 1 1841857 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Culturomica Culturomica massiliensis 1.00 OTU_ 565 SET 1 487175 Proteobacteria Betaproteobacteria Burkholderiales Sutterellaceae Parasutterella Parasutterella excrementihomims 1.00 OTU_ 569 SET 1 45851 Firmicutes Clostridia Clostridiales Lachnospiraceae Butyrivibrio Butyrivibrio crossotus 1.00 OTU SET 69825 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] 1.00 Petition 870260080213, dated 10 / 08 / 2026, p. 118 / 398 108 / 296 1956 1 character OTU_ 1733 SET 1 1050201 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Allobaculum Allobaculum stercoricanis DSM 13633 1.00 OTU_ 3144 SET 1 818 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides thetaiotaomicron 1.00 OTU_ 8 SET 1 762948 Actinobacteria Actinobacteria Micrococcales Micrococcaceae Rothia Rothia deniocariosa ATCC 17931 0.63 OTU_ 325 SET 1 137732 Firmicutes Bacilli Lactobacillales Carnobacteriaceae Granulicatella Granulicatella elegans 1.00 OTU_ 1651 SET 1 1034346 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Dielma Dielma fastidiosa 1.00 OTU_ 3198 SET 1 1211819 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Holdemania Holdemania massiliensis AP2 1.00 OTU_ 2160 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] clostridioforme 1,00 OTU_ 1093 CONJUNTO 1 1019 Bacteroidetes Flavobacteriia Flavobacteriales Flavobacteriaceae Capnocytophaga Capnocytophaga sputigena 1,00 OTU_ 1655 CONJUNTO 1 288966 Firmicutes Clostridia Clostridiales Clostridiaceae Lutispora Lutispora thermophila 1,00 OTU_ 1269 CONJUNTO 1 74426 Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Collinsella Collinsella aerofaciens 1,00 OTU_ 1781 CONJUNTO 1 272548 Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces Actinomyces dentalis 1,00 OTU_ 1825 CONJUNTO 1 39777 Fumicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella atypica 1,00 OTU_ 2240 CONJUNTO 1 46503 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides merdae 1,00 OTU_ 3124 CONJUNTO 1 1717 Actinobacteria Actinobacteria Corynebacteriales Corynebacteriaceae Corynebacterium Corynebacterium diphteriae 1,00 OTU_ 3151 CONJUNTO 1 84112 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Eggerthella Eggerthella lenta 1,00 OTU_ 728 CONJUNTO 1 384636 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides xylanolyticus 1,00 OTU_ 939 CONJUNTO 1 216940 Tenericutes Mollicutes Entomoplasmatales Spiroplasmataceae Spiroplasma Spiroplasma lantpyridicola 1,00 OTU_ 947 CONJUNTO 1 2087 Tenericutes Mollicutes Anaeroplasmatales Anaeroplasmataceae Anaeroplasma Anaeroplasma abactoclasticum 1,00 OTU_ 1036 CONJUNTO 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1,00 OTU CONJUNTO 45634 Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus 1,00, Petição 870260080213, de 10 / 08 / 2026, pág. 119 / 398 109 / 296 2880 1 cristatus OTU_ 1594 SET 1 89014 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia luti 1.00 OTU_ 1852 SET 1 253257 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] amygdalinum 1.00 OTU_ 969 SET 1 466107 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulflovibrio Desulflovibrio litoralis 0.50 OTU_ 2702 SET 1 871665 Firmicutes Clostridia Clostridiales Lachnospiraceae Blautia Blautia faecis 1.00 OTU_ 1134 SET 1 938293 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Anaerococcus Anaerococcus provenciensis 1.00 OTU_ 1264 SET 1 29466 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella parvula 1.00 OTU_ 1355 SET 1 1689 Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifldobacterium dentium 1,00 OTU_ 1422 CONJUNTO 1 47678 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides caccae 1,00 OTU_ 1431 CONJUNTO 1 259063 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerocolumna Anaerocolumna jejuensis 1,00 OTU_ 1504 CONJUNTO 1 879566 Firmicutes Clostridia Clostridiales Lachnospiraceae Acetatifactor Acetatifactor muris 1,00 OTU_ 1683 CONJUNTO 1 1583331 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas pasteri 1,00 OTU_ 2053 CONJUNTO 1 575 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Raoultella Raoultella planticola 1,00 OTU_ 235 CONJUNTO 1 979627 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoanaerobaculum Lachnoanaerobaculum orale 1,00 OTU_ 2479 CONJUNTO 1 33033 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Parvimonas Parvimonas micra 1,00 OTU_ 2881 CONJUNTO 1 51048 Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Actinobacillus Actinobacillus porcinus 1,00 OTU_ 304 CONJUNTO 1 840 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella loescheii 1,00 OTU_ 330 CONJUNTO 1 1583331 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas pasteri 1,00 OTU_ 383 CONJUNTO 1 1660 Actinobacteria Actinobacteria Actinomycetales Actinomycetaceae Actinomyces Actinomyces odontolyticus 1,00 OTU_ 549 CONJUNTO 1 29466 Firmicutes Negativicutes Veillonellales Veillonellaceae Veillonella Veillonella parvula 1,00 OTU_ 572 CONJUNTO 1 320502 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] alkalicellulosi 1,00 OTU_ 622 CONJUNTO 1 1236517 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella fusca JCM 17724 1,00 OTU_ 743 SET 1 617123 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoanaerobaculum Lachnoanaerobaculum 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 120 / 398 110 / 296 umeaense OTU_ 2250 SET 1 546 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Citrobacter Citrobacter freundii 1.00 OTU_ 1367 SET 1 1298596 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus faecis JCM 15917 1.00 OTU_ 1067 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 1072 SET 1 358743 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] citoniae 1.00 OTU_ 1963 SET 1 1050201 Firmicutes Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Allobaculum Allobaculum stercoricanis DSM 13633 1.00 OTU_ 1171 SET 1 1264 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus albus 1.00 OTU_ 1895 SET 1 471875 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminococcus Ruminococcus lactaris ATCC29176 1.00 OTU_ 211 SET 1 28135 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella oris 1.00 OTU_ 2165 SET 1 82171 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio zosterae 1.00 OTU_ 2395 SET 1 37658 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] populeti 1.00 OTU_ 2682 SET 1 483 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Chromobacterium Neisseria cinerea 1.00 OTU_ 2766 SET 1 333367 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] asparagiforme 1.00 OTU_ 309 SET 1 501496 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas bennonis 1.00 OTU_ 723 SET 1 99656 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] fimetarium 1.00 OTU_ 973 SET 1 1379 Firmicutes Bacilli Bacillales Not classified. NA Gemella Gemella haemolysans 1,00 OTU_ 1231 SET 1 84032 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] thermosuccinogenes 1.00 OTU_ 2687 SET 1 1236512 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides rodentium JCM 16496 1.00 OTU_ 2840 SET 1 1297617 Firmicutes Clostridia Clostridiales Not classified. NA Intestinimonas Intestinimonas butyriciproducens 1.00 OTU_ 3053 SET 1 411467 Firmicutes Clostridia Clostridiales Not classified. NA Pseudoflavonifractor Pseudoflavonifactor capillosus ATCC 29799 1.00 OTU SET 39483 Firmicutes Erysipelo- Erysipelotrichal Erysipelotrichaceae Faecalitalea Faecalitalea 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 121 / 398 111 / 296 3199 1 trichia es cylindroides OTU_ 3207 SET 1 46503 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides merdae 1.00 OTU_ 1427 SET 1 879566 Firmicutes Clostridia Clostridiales Lachnospiraceae Acetatifactor Acetatifactor muris 1.00 OTU_ 901 SET 1 1107316 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Neisseria Neisseria oralis 1.00 OTU_ 1223 SET 1 584 Proteobacteria Gammaproteobacteria Enterobacterales Morganellaceae Proteus Proteus mirabilis 1.00 OTU_ 1608 SET 1 28124 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas endodontalis 1.00 OTU_ 1798 SET 1 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis 1.00 OTU_ 2066 SET 1 109327 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Uncertain Site Anaerovorax Anaerovorax odorimutans 1,00 OTU_ 2280 CONJUNTO 1 1033744 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Peptoniphilus Peptoniphilus senegalensis JC140 1,00 OTU_ 2393 CONJUNTO 1 320502 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] alkalicellulosi 1,00 OTU_ 3125 CONJUNTO 1 901 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio piger 1,00 OTU_ 1762 CONJUNTO 1 483 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Chromobacterium Neisseria cinerea 1,00 OTU_ 2848 CONJUNTO 1 657309 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides xylanisolvens XB1A 1,00 OTU_ 298 CONJUNTO 1 671218 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Alloprevotella Alloprevotella rava 1,00 OTU_ 376 CONJUNTO 1 536441 Bacteroidetes Flavobacteriia Flavobacteriales Flavobacteriaceae Chryseobacterium Chryseobacterium taklimakanense 1,00 OTU_ 571 SET 1 873513 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella buccae ATCC 33574 1.00 OTU_ 618 SET 1 76123 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella enoeca 1.00 OTU_ 2595 SET 1 1118060 Actinobacteria Coriobacteriia Coriobacteriales Coriobacteriaceae Enorma Enorma massiliensis phI 1.00 OTU_ 266 SET 1 89152 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Achromobacter [Clostridium] hiranonis 1.00 OTU_ 514 SET 1 888727 Firmicutes Clostridia Clostridiales Clostridiales Family XIII. Incertae Sedis Not classified. NA Eubacterium sulci ATCC 35585 1.00 OTU SET 76122 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Alloprevotella Alloprevotella 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 122 / 398 112 / 296 94 1 tannerae OTU_ 2059 SET 1 303 Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas pulida 1.00 OTU_ 3060 SET 1 1541 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Terrisporobacter Terrisporobacter mayombei 1.00 OTU_ 1475 SET 1 507751 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Peptoniphilus Peptoniphilus koenoeneniae 1.00 OTU_ 1204 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 1626 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 3028 SET 1 515620 Firmicutes Clostridia Clostridiales Eubacteriaceae Eubacterium [Eubacterium] eligens ATCC27750 1.00 OTU_ 1090 SET 1 38302 Actinobacteria Actinobacteria Corynebacteriales Corynebacteriaceae Corynebacterium Corynebacterium mycetoides 1,00 OTU_ 186 CONJUNTO 1 53419 Spirochaetes Spirochaetia Spirochaetales Spirochaetaceae Treponema Treponema socranskii 1,00 OTU_ 2158 CONJUNTO 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1,00 OTU_ 2205 CONJUNTO 1 726 Proteobacteria Gammaproteobac teria Pasteurellales Pasteurellaceae Haemophilus Haemophilus haemolyticus 1,00 OTU_ 2345 CONJUNTO 1 328812 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Parabacteroides Parabacteroides goldsteinii 1,00 OTU_ 1408 CONJUNTO 1 40324 Proteobacteria Gammaproteobac teria Xanihomonadales Xanthomonadaceae Stenotrophomonas Stenotrophomonas maltophilia 1,00 OTU_ 1476 CONJUNTO 1 1297617 Firmicutes Clostridia Clostridiales Não clasificado. NA Intestinimonas Intestinimonas butyriciproducens 1,00 OTU_ 1731 CONJUNTO 1 555088 Firmicutes Clostridia Clostridiales Syntrophomonadaceae Dethiobacter Dethiobacter alkaliphilus AHT 1 1,00 OTU_ 2082 SET 1 901 Proteobacteria Deltaproteobacteria Desulfovibrionales Desulfovibrionaceae Desulfovibrio Desulfovibrio piger 1.00 OTU_ 2114 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 2283 SET 1 308994 Firmicutes Negativicutes Veillonellales Veillonellaceae Dialister Dialister propionicifaciens 1.00 OTU_ 238 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 2517 SET 1 29375 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] xylanolyticum 1.00 OTU CONJUNTO 1796610 Actinobacteria Coriobacteriia Eggerthellales Eggerthellaceae Enterorhabdus Enterorhabdus 1.00, Petition 870260080213, de 10 / 08 / 2026, pág. 123 / 398 113 / 296 609 1 muris OTU_ 1208 CONJUNTO 1 290052 Firmicutes Clostridia Clostridiales Ruminococcaceae Acetivibrio Acetivibrio ethanolgignens 1,00 OTU_ 1844 CONJUNTO 1 546 Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Citrobacter Citrobacter freundii 1,00 OTU_ 1560 CONJUNTO 1 988946 Cyanobacteria Não clasificado. NA Nostocales Symphyonemataceae Loriellopsis Loriellopsis cavernicola 1,00 OTU_ 1819 CONJUNTO 1 1605 Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus animalis 1,00 OTU_ 2423 CONJUNTO 1 166486 Firmicutes Clostridia Clostridiales Lachnospiraceae Roseburia Roseburia intestinalis 1,00 OTU_ 1517 CONJUNTO 1 160404 Firmicutes Clostridia Clostridiales Lachnospiraceae Tyzzerella [Clostridium] lactatiferment ans 1,00 OTU_ 114 CONJUNTO 1 1852370 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotellamassilia Prevotellamassilia timonensis 1,00 OTU_ 1248 CONJUNTO 1 474960 Firmicutes Clostridia Clostridiales Ruminococcaceae Hydrogenoanaerobact erium Hydrogenoanaerobacterium saccharovorans 1,00 OTU_ 84 CONJUNTO 1 1017 Bacteroidetes Flavobacteriia Flavobacteriales Flavobacteriaceae Capnocytophaga Capnocytophaga gingivalis 1,00 OTU_ 1624 CONJUNTO 1 1168289 Bacteroidetes Bacteroidia Bacteroidales Marinilabiliaceae Marinilabilia Marinilabilia salmonicolor JCM.21150 1,00 OTU_ 2918 CONJUNTO 1 246787 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides cellulosilyticus 1,00 OTU_ 1293 CONJUNTO 1 76936 Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter Helicobacter typhlonius 1,00 OTU_ 2664 CONJUNTO 1 94869 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium gasigenes 1,00 OTU_ 2728 CONJUNTO 1 204516 Bacteroidetes Bacteroidia Bacteroidales Bacteroidaceae Bacteroides Bacteroides massiliensis 1,00 OTU_ 911 SET 1 1161098 Firmicutes Tissierellia Tissierellales Peptoniphilaceae Anaerococcus Anaerococcus octavius ​​NCTC 9810 1.00 OTU_ 1930 SET 1 28117 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes putredinis 1.00 OTU_ 1625 SET 1 1002367 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella stercorea DSM 18206 1.00 OTU_ 3162 SET 1 261299 Firmicutes Clostridia Clostridiales Peptostreptococcaceae Intestinibacter Lntestinibacter bartlettii 1.00 OTU SET 46206 Firmicutes Clostridia Clostridiales Lachnospiraceae Pseudobutyrivibrio Pseudobutyri- 1.00, Petition 870260080213, dated 10 / 08 / 2026, p. 124 / 398 114 / 296 1255 1 vibrio ruminis OTU_ 2161 SET 1 515619 Firmicutes Clostridia Clostridiales Lachnospiraceae Myxococcus [Eubacterium rectale] ATCC 33656 1.00 OTU_ 2320 SET 1 28118 Bacteroidetes Bacteroidia Bacteroidales Odoribacteraceae Odoribacter Odoribacter splanchnicus 1.00 OTU_ 2674 SET 1 1531 Firmicutes Clostridia Clostridiales Lachnospiraceae Lachnoclostridium [Clostridium] clostridioforme 1.00 OTU_ 729 SET 1 215580 Proteobacteria Betaproteobacteria Burkholderiales Comamonadaceae Schlegelella Schlegelella thermodepolymerans 1.00 OTU_ 730 SET 1 1796646 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Muribaculum Muribaculum intestinale 1.00 OTU_ 994 SET 1 1125779 Actinobacteria Actinobacteria Corynebacteriales Corynebacteriaceae Corynebacterium Corynebacterium pyruviciproducens ATCC BAA-1742 1.00 OTU_ 1282 SET 1 84026 Firmicutes Clostridia Clostridiales Ruminococcaceae Ruminiclostridium [Clostridium] methylpentosum 1,00 OTU_ 1717 CONJUNTO 1 327575 Bacteroidetes Flavobacteriia Flavobacteriales Flavobacteriaceae Capnocytophaga Capnocytophaga leadbetteri 1,00 OTU_ 2829 CONJUNTO 1 549 Proteobacteria Gammaproteobacteria Enterobacterales Erwiniaceae Pantoea Pantoea agglomerans 1,00 OTU_ 398 CONJUNTO 1 28129 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella Prevotella denticola 1,00 OTU_ 971 CONJUNTO 1 483 Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Chromobacterium Neisseria cinerea 1,00 OTU_ 1659 CONJUNTO 1 1450648 Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium Clostridium oryzae 1,00 OTU_ 881 CONJUNTO 1 214856 Bacteroidetes Bacteroidia Bacteroidales Rikenellaceae Alistipes Alistipes flnegoldii 1,00 OTU_ 1581 CONJUNTO 1 264463 Firmicutes Clostridia Clostridiales Lachnospiraceae Anaerosporobacter Anaerosporobacter mobihs 1,00 OTU_ 2148 CONJUNTO 1 319644 Firmicutes Clostridia Clostridiales Ruminococcaceae Saccharofermentans Saccharofermentans aceligenes 1,00 OTU_ 2969 SET 1 515619 Firmicutes Clostridia Clostridiales Lachnospiraceae Myxococcus [Eubacterium rectale] ATCC 33656 1.00 OTU_ 717 SET 1 478 Proteobacteria Gammaproteobacteria Pseudomonadales Moraxellaceae Moraxella Moraxella nonliquefaciens 1.00, Table 2: Differences in fecal bacteria species derived from WGS by treatment response status. CAG Number p-value Status Number Species Level Genus Family Petition 870260080213, dated 10 / 08 / 2026, p. 125 / 398 115 / 296 Unadjusted response CAG taxonomy CAG00720 0.017 NR CAG00720 Species Anaerotruncus colihominis Anaerotruncus Ruminococcaceae CAG00124 0.018 NR CAG00124 Species Klebsiella variicola Klebsiella Enterobacteriaceae CAG00011 0.035 NR CAG00011 Species Escherichia coli Escherichia Enterobacteriaceae CAG00050 0.043 NR CAG00050 Species Bacteroides thetaiotaomicran Bacteroides Bacteroidaceae CAG00834 0.047 NR CAG00834 Species Oxalobacter formigenes Oxalobacter Oxalobacteraceae CAG00426 0.06 NR CAG00426 Species Paraprevotella clara Paraprevotella Prevotellaceae CAG01272 0.06 NR CAG01272 Species Adlercreutzia equolifaciens Adlercreutzia Eggerthellaceae CAG01320 0.066 NR CAG01320 Species Clostridium bolteae Lachnoclostridium Lachnospiraceae CAG00012 0.069 NR CAG00012 Species Klebsiella pneumoniae Klebsiella Enterobacteriaceae CAG00826 0.089 NR CAG00826 Genus Clostridium not classified Clostridium Clostridiaceae CAG00117 0.092 NR CAG00117 Species Parabacteroides merdae Parabacteroides Porphyromonadaceae CAG00093 0.116 NR CAG00093 Species Klebsiella quasipneumoniae Klebsiella Enterobacteriaceae CAG00114 0.116 NR CAG00114 Genus Lachnoclostridium not classified Lachnoclostridium Lachnospiraceae CAG00161 0.116 NR CAG00161 Species Bacteroides coprocola Bacteroides Bacteroidaceae CAG00163 0.116 NR CAG00163 Species Prevotella sp. CAG:255 Prevotella Prevotellaceae CAG00256 0.116 NR CAG00256 Family Lachnospiraceae not classified Lachnospiraceae not classified Lachnospiraceae CAG00462 0.116 NR CAG00462 Species Streptococcus pasteurianus Streptococcus Streptococcaceae CAG00815 0.116 NR CAG00815 Species Lactococcus lactis Lactococcus Streptococcaceae CAG00817 0.116 NR CAG00817 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00010 2 0.116 NR CAG00010 2 NA Not classified. Not classified. Not classified. CAG01203 0,116 NR CAG01203 Species Streptococcus mutans Streptococcus Streptococcaceae CAG00949 0.12 NR CAG00949 Species Ruminococcaceae bacterium D16 Ruminococcaceae unclassified Ruminococcaceae CAG00775 0.13 NR CAG00775 Species Firmicutes bacterium CAG:102 Firmicutes unclassified Firmicutes unclassified CAG00931 0.131 NR CAG00931 Genus Oscillospiraceae unclassified Oscillospiraceae CAG01263 0.154 NR CAG01263 Species Clostridium clostridioforme Lachnospiraceae CAG00086 0.154 NR CAG00086 Species Bacteroides massiliensis Bacteroides Bacteroidaceae CAG00113 0.157 NR ​​CAG00113 Species Clostridium scindens Lachnoclostridium Lachnospiraceae, Petition 870260080213, dated 10 / 08 / 2026, page 126 / 398 116 / 296 CAG01323 0.165 NR CAG01323 Species Parabacteroides merdae Parabacteroides Porphyromonadaceae CAG00502 0.184 NR CAG00502 Species Eubacterium sp. CAG: 161 Eubacterium Eubaeteriaceae CAG00254 0.193 NR CAG00254 Species Ruminococcus gnavus Blautia Lachnospiraceae CAG01264 0.197 NR CAG01264 Species Clostridium clostridioforme Lachnoclostridium Lachnospiraceae CAG00327 0.009 R CAG00327 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG00659 0.017 R CAG00659 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00492 0.034 R CAG00492 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG00518 0.034 R CAG00518 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG01146 0.034 R CAG01146 Genus Oscillibacter not classified Oscillibacter Oscillospiraceae CAG00079 0.038 R CAG00079 Species Clostridium sp.GAG: 7 Clostridiales not classified Clostridiales not classified CAG00393 0.048 R CAG00393 Species Eubacterium sp. CAG: 86 Eubacterium Eubaeteriaceae CAG00766 0.065 R CAG00766 Species Firmicutes bacterium CAG: 176 Firmicutes not classified Firmicutes not classified CAG00095 0.065 R CAG00095 Species Akkennansia sp. CAG7344 Akkermansia Akkermansiaceae CAG00010 1 0.065 R CAG00010 1 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00342 0.065 R CAG00342 Species Bifidobacterium pseudocatenulatum Bifidobacterium Bifidobacteriaceae CAG00303 0.065 R CAG00303 Genus Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00337 0.065 R CAG00337 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG00381 0.065 R CAG00381 Species Clostridium sp.CAG: 242 Clostridiales not classified Clostridiales not classified CAG00559 0.065 R CAG00559 Family Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00570 0.065 R CAG00570 NA Not classified. Not classified. Not classified. CAG00635 0.065 R CAG00635 Species Bifidobacterium bifidum Bifidobacterium Bifidobacteriaceae CAG00636 0.065 R CAG00636 Genus Roseburia not classified Roseburia Lachnospiraceae CAG00660 0.065 R CAG00660 Species Alistipes timonensis Alistipes Rikenellaceae CAG00669 0.065 R CAG00669 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00708 0.065 R CAG00708 Species Alistipes senegalensis Alistipes Rikenellaceae CAG00773 0.065 R CAG00773 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00807 0.065 R CAG00807 Genus Holdemanella not classified Holdemanella Erysipelothrichaceae. Petition 870260080213, dated 10 / 08 / 2026, p. 127 / 398 117 / 296 CAG00880 0.065 R CAG00880 Species Subdoligranulum sp. CAG: 314 Subdoligranulum Ruminococcaceae CAG00907 0.065 R CAG00907 Family Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01086 0.065 R CAG01086 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG01215 0.065 R CAG01215 Family Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01277 0.065 R CAG01277 Genus Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01308 0.065 R CAG01308 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00577 0.073 R CAG00577 Species Faecalibacterium prausnitzii 3 (1.2-6) Faecalibacterium Ruminococcaceae CAG00506 0.083 R CAG00506 Genus Ruminococcaceae unclassified Ruminococcaceae unclassified Ruminococcaceae CAG00852 0.087 R CAG00852 Species Clostridium spiroforme Erysipelatoclostridium Erysipelotrichaceae CAG01046 0.091 R CAG01046 Genus Intestinimonas not classified Intestinimonas Clostridiales not classified CAG00320 0.092 R CAG00320 Species Phaseolarctobacterium sp. CAG: 207 Phascolarctobacterium Acidaminococcaceae CAG00619 0.097 R CAG00619 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG01366 0.098 R CAG01366 Species Streptococcus parasanguinis Streptococcus Streptococcaceae CAG00509 0.1 R CAG00509 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00441 0.104 R CAG00441 Genus Blautia not classified Blautia Lachnospiraceae CAG00249 0.106 R CAG00249 Species Clostridium leptum Ruminococcaceae CAG50003 0.12 R CAG50003 Clostridiales genus not classified Clostridiales not classified Clostridiales not classified CAG00039 0,121 R CAG00039 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00127 0, 121 R CAG00127 Family Lachnospiraceae not classified Lachnospiraceae not classified Lachnospiraceae CAG00854 0, 121 R CAG00854 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG00166 0, 121 R CAG00166 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00272 0, 121 R CAG00272 Species Faecalibacterium 5 (sp. CAG: 74) Faecalibacterium Ruminococcaceae CAG00294 0, 121 R CAG00294 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00367 0, 121 R CAG00367 Species Firmicutes bacterium CAG: 170 Firmicutes not classified Firmicutes not classified CAG00445 0, 121 R CAG00445 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified, Petition 870260080213, dated 10 / 08 / 2026, page 128 / 398 118 / 296 CAG00452 0, 121 R CAG00452 Species Clostridium sp, CAG:167 Clostridiales not classified Clostridiales not classified CAG00497 0, 121 R CAG00497 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00505 0, 121 R CAG00505 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00721 ​​0, 121 R CAG00721 ​​Species Methanobrevibacter smithii 1 Methanobrevibacter Methanobacteriaceae CAG00624 0, 121 R CAG00624 Phylum Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00648 0, 121 R CAG00648 Genus Eubacterium not classified Eubacterium Eubacteriaceae CAG00735 0, 121 R CAG00735 Genus Eubacterium not classified Eubacterium Eubacteriaceae CAG00770 0, 121 R CAG00770 Family Eggerthellaceae not classified Eggerthellaceae not classified Eggerthellaceae CAG00812 0, 121 R CAG00812 Species Catenibacterium sp.CAG: 290 Catenibacterium Erysipelotrichaceae CAG00861 0, 121 R CAG00861 Species Oscillibacter sp. CAG: 241 Oscillibacter Oscillospiraceae CAG00863 0, 121 R CAG00863 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG00925 0, 121 R CAG00925 NA Not classified. Not classified. Not classified. CAG00934 0, 121 R CAG00934 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01003 0, 121 R CAG01003 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG01325 0, 121 R CAG01325 Genus Lachnoclostridium not classified Lachnoclostridium Lachnospiraceae CAG02021 0, 121 R CAG02021 Genus Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01349 0, 121 R CAG01349 NA Not classified. Not classified. Not classified.CAG01350 0, 121 R CAG01350 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01402 0, 121 R CAG01402 Species Turicibacter sp. H121 Turicibacter Erysipelotrichaceae CAG01403 0.121 R CAG01403 Species Bacteroides stercorirosoris Bacteroides Bacteroidaceae CAG01551 0.121 R CAG01551 Genus Oscillibacter unclassified Oscillibacter Oscillospiraceae CAG01028 0.13 R CAG01028 Species Ruminoeoccaceae bacterium LM158 Ruminococcaceae unclassified Ruminococcaceae CAG00121 0.134 R CAG00121 Species Bacteroides flnegoldii Bacteroides Bacteroidaceae CAG00670 0.134 R CAG00670 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00324 0.137 R CAG00324 Species Firmicutes bacterium CAG: 94 Firmicutes not classified Firmicutes not classified CAG00218 0.143 R CAG00218 Species Barnesiella intestinihominis Barnesiella Porphyromonadaceae. Petition 870260080213, dated 10 / 08 / 2026, page 129 / 398 119 / 296 CAG00755 0.143 R CAG00755 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG00560 0.175 R CAG00560 Genus Subdoligranulum not classified Subdoligranulum Ruminococcaceae CAG00259 0.177 R CAG00259 Genus Firmicutes not classified Firmicutes not classified Firmicutes not classified CAG01039 0.177 R CAG01039 Genus Faecalibacterium not classified Faecalibacterium Ruminococcaceae CAG00239 0.183 R CAG00239 Species Flavonifractor plautii Flavonifractor Clostridiales not classified CAG00112 0.184 R CAG00112 Species Blautia sp.CAG: 52 Blautia Lachnospiraceae CAG00697 0.196 R CAG00697 Genus Hungatella not classified Hungatella Clostridiaceae CAG00595 0.201 R CAG00595 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00629 0.213 R CAG00629 Species Firmicutes bacterium GAG: 124 Firmicutes not classified Firmicutes not classified CAG00549 0.219 R CAG00549 Species Bifidobacterium longum Bifidobacterium Bifidobacteriaceae CAG00328 0.221 R CAG00328 Species Alistipes indistinctus Alistipes Rikenellaceae CAG00760 0.222 R CAG00760 Species Ruminococcus sp. GAG: 177 Ruminococcus Ruminococcaceae CAG00031 0.222 R CAG00031 NA Not classified. Not classified. Not classified.CAG00102 0.222 R CAG00102 Genus Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00130 0.222 R CAG00130 Species Weissella confusa Weissella Leuconostocaceae CAG00134 0.222 R CAG00134 Species Cloacibacillus porcorum Cloacibacillus Synergistaceae CAG00145 0.222 R CAG00145 Genus Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG00200 0.222 R CAG00200 Genus Flavonifractor not classified Flavonifractor Clostridiales not classified CAG00179 0.222 R CAG00179 Species Blautia sp. CAG: 237 Blautia Lachnospiraceae CAG00183 0.222 R CAG00183 Species Ruminococcus sp. CAG: 60 Ruminococcus Ruminococcaceae CAG00198 0.222 R CAG00198 NA Not classified. Not classified. Not classified.CAG00214 0.222 R CAG00214 Species Prevotella corporis Prevotella Prevotellaceae CAG00261 0.222 R CAG00261 Genus Oscillibacter unclassified Oscillibacter Oscillospiraceae CAG00241 0.222 R CAG00241 Species Anaerotruncus sp. CAG: 390 Anaerotruncus Ruminococcaceae CAG00363 0.222 R CAG00363 Genus Intestimmonas unclassified Intestimmonas Clostridiales unclassified CAG00373 0.222 R CAG00373 Genus Oscillibacter unclassified Oscillibacter Oscillospiraceae CAG00436 0.222 R CAG00436 Species Clostridium sp. CAG: 299 Clostridiales not classified Clostridiales not classified. Petition 870260080213, dated 10 / 08 / 2026, page 130 / 398 120 / 296 CAG00470 0.222 R CAG00470 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG00541 0.222 R CAG00541 Species Dorea sp. CAG: 105 Dorea Lachnospiraceae CAG00542 0.222 R CAG00542 Species Butynvibrio crossotus Butyrivibrio Lachnospiraceae CAG00644 0.222 R CAG00644 Species Clostridium sp. CAG: 226 Clostridiales unclassified Clostridiales unclassified CAG00658 0.222 R CAG00658 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00676 0.222 R CAG00676 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00698 0.222 R CAG00698 Genus Ruminococcus unclassified Ruminococcus Ruminococcaceae CAG00703 0.222 R CAG00703 Species Candidatus Methanomassiliicoccus intestinalis Methanomassiliicoccus Methanomassiliicoccaceae CAG00831 0.222 R CAG00831 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00841 0,222 R CAG00841 Species Firmicutes bacterium CAG: 345 Firmicutes unclassified Firmicutes unclassified CAG00850 0.222 R CAG00850 Genus Blautia unclassified Blautia Lachnospiraceae CAG00851 0.222 R CAG00851 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00048 1 0.222 R CAG00048 1 Order Clostridiales unclassified Clostridiales unclassified Clostridiales unclassified CAG00866 0.222 R CAG00866 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00892 0.222 R CAG00892 Phylum Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00959 0.222 R CAG00959 Genus Alistipes unclassified Alistipes Rikenellaceae CAG00965 0.222 R CAG00965 Genus Firmicutes unclassified Firmicutes unclassified Firmicutes unclassified CAG00988 0,222 R CAG00988 Species Clostridium sp. CAG: 349 Clostridiales not classified Clostridiales not classified CAG01047 0.222 R CAG01047 Family Clostridiales not classified, Family XIII. Incertae Sedis Clostridiales not classified, Family XIII. Incertae Sedis Clostridiales Family XIII. Incertae Sedis CAG01075 0.222 R CAG01075 Order Clostridiales not classified Clostridiales not classified Clostridiales not classified CAG01099 0.222 R CAG01099 Species Raoultella ornithinoiytica Raoultella Enterobacteriaceae CAG01108 0.222 R CAG01108 Species Clostridium sp. CAG: 798 Clostridiales unclassified Clostridiales unclassified CAG01145 0.222 R CAG01145 Genus Bacteroides unclassified Bacteroides Bacteroidaceae CAG01156 0.222 R CAG01156 Genus Eubacterium unclassified Eubacterium Eubacteriaceae, Petition 870260080213, dated 10 / 08 / 2026, page 131 / 398 121 / 296 CAG01169 0.222 R CAG01169 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG01240 0.222 R CAG01240 Species Parabacteroides gordonii Parabacteroides Porphyromonadaceae CAG00068 2 0.222 R CAG00068 2 Genus Porphyromonas not classified Porphyromonas Porphyromonadaceae CAG01372 0.222 R CAG01372 Genus Oscillibacter not classified Oscillibacter Oscillospiraceae CAG01394 0.222 R CAG01394 Genus Blautia not classified Blautia Lachnospiraceae CAG00052 0.225 R CAG00052 Species Parabacteroides goldsteinii Parabacteroides Porphyromonadaceae CAG00116 0.225 R CAG00116 Species Bacteroides nordii Bacteroides Bacteroidaceae CAG00429 0.225 R CAG00429 Species Eubacterium sp. CAG: 248 Eubacterium Eubacteriaceae CAG00702 0.24 R CAG00702 Species Bifidobacterium adolescentis Bifidobacterium Bifidobacteriaceae CAG00309 0.243 R CAG00309 Species Alistipes onderdonkii Alistipes Rikenellaceae CAG01637 0,259 R CAG01637 Species Firmicutes bacterium CAG: 65 Firmicutes not classified Firmicutes not classified CAG01051 0.265 R CAG01051 Genus Oscillibacter not classified Oscillibacter Oscillospiraceae CAG00792 0.265 R CAG00792 Species Firmicutes bacterium CAG: 65 Firmicutes not classified Firmicutes not classified CAG00208 0.266 R CAG00208 Species Faecalibacterium Faecalibacterium Ruminococcaceae CAG01700 0.279 R CAG01700 Family Ruminococcaceae not classified Ruminococcaceae not classified Ruminococcaceae CAG01371 0.279 R CAG01371 Species Escherichia coli Escherichia Enterobacteriaceae CAG00653 0.29 R CAG00653 Species Eubacterium siraeum Ruminiclostridium Ruminococcaceae CAG00520 0.29 R CAG00520 Species Firmicutes bacterium CAG: 56 Firmicutes not classified Firmicutes not classified CAG00273 0.311 R CAG00273 Species Blautia sp. CAG: 37 Blautia Lachnospiraceae, Petition 870260080213, dated 10 / 08 / 2026, page 132 / 398 122 / 296 Table 2A - Shows the bacterial genes used to characterize bacterial coabundance gene groups (CAGs) and the corresponding SEQ ID NO. for each gene in the bacteria of interest. Each of the listed CAG groups and genes is available online at meta.genomics.cn / meta / dataTools, and is incorporated here by reference. ID CAG Nome do gene SEQ ID CAG00327 V1.Fl20 GL0119476 SEQ ID NO: 877 CAG00327 V1.UC26-4 GL0088915 SEQ ID NO: 878 CAG00327 V1.Fl17 GL0037272 SEQ ID NO: 879 CAG00327 V1.Fl17 GL0078727 SEQ ID NO: 880 CAG00327 O2.UC24-2 GL0094271 SEQ ID NO: 881 CAG00327 V1.Fl17 GL0207542 SEQ ID NO: 882 CAG00327 MH0348 GL0074623 SEQ ID NO: 883 CAG00327 MH0348 GL0010939 SEQ ID NO: 884 CAG00327 MH0373 GL0012294 SEQ ID NO: 885 CAG00327 MH0448 GL0074435 SEQ ID NO: 886 CAG00327 V1.UC26-4 GL0005764 SEQ ID NO: 887 CAG00327 O2.UC52-0 GL0057691 SEQ ID NO: 888 CAG00327 V1.UC26-4 GL0145819 SEQ ID NO: 889 CAG00327 V1.Fl17 GL0032281 SEQ ID NO: 890 CAG00327 V1.UC26-4 GL0185580 SEQ ID NO: 891 CAG00327 V1.Fl17 GL0175729 SEQ ID NO: 892 CAG00327 V1.UC26-4 GL0030591 SEQ ID NO: 893 CAG00327 MH0343 GL0081662 SEQ ID NO: 894 CAG00327 MH0348 GL0118307 SEQ ID NO: 895 CAG00327 V1.UC26-4 GL0004865 SEQ ID NO: 896 CAG00327 V1.UC26-4 GL0083941 SEQ ID NO: 897 CAG00327 V1.UC26-4 GL0101656 SEQ ID NO: 898 CAG00327 MH0348 GL0087364 SEQ ID Petition 870260080213, dated 10 / 08 / 2026, p. 133 / 398 123 / 296 NO: 899 CAG00327 V1.F117 GL0122971 SEQ ID NO: 900 CAG00327 MH0372 GL0069396 SEQ ID NO: 901 CAG00327 MH0366 GL0119156 SEQ ID NO: 902 CAG00327 MH0372 GL0071516 SEQ ID NO: 903 CAG00327 MH0348 GL0064411 SEQ ID NO: 904 CAG00327 MH0343 GL0166170 SEQ ID NO: 905 CAG00327 V1.UC26-4 GL0076251 SEQ ID NO: 906 CAG00327 MH0343 GL0092435 SEQ ID NO: 907 CAG00327 V1.F117 GL0016953 SEQ ID NO: 908 CAG00327 V1.UC26-4 GL0143205 SEQ ID NO: 909 CAG00327 MH0372 GL0055320 SEQ ID NO: 910 CAG00327 V1.UC26-4 GL0055452 SEQ ID NO: 911 CAG00327 MH0348 GL0106302 SEQ ID NO: 912 CAG00327 MH0372 GL0097771 SEQ ID NO: 913 CAG00327 764062976- stoo11 revised scaffold12924 1 gene147101 SEQ ID NO: 914 CAG00327 O2.UC48-1,0 GL0017424 SEQ ID NO: 915 CAG00327 O2.UC48-1,0 GL0207849 SEQ ID NO: 916 CAG00327 V1.Fl17 GL0115124 SEQ ID NO: 917 CAG00327 MH0203 GL0130549 SEQ ID NO: 918 CAG00327 V1.UC26-4 GL0093892 SEQ ID NO: 919 CAG00327 MH0348 GL0072323 SEQ ID NO: 920 CAG00327 MH0348 GL0058041 SEQ ID NO: 921 CAG00327 764062976- stool1 revised scaffold30750 1 gene162103 SEQ ID NO: 922 CAG00327 764062976- stool1 revised scaffold4128 1 gene64730 SEQ ID NO: 923 CAG00327 MH0343 GL0169255 SEQ ID NO: 924 CAG00327 MH0343 GL0093310 SEQ ID NO: 925 CAG00327 V1.UC26-4 GL0016002 SEQ ID NO: 926 CAG00659 O2.UC48-0 GL0168719 SEQ ID NO: 927 CAG00659 V1.UC55-0 GL0148491 SEQ ID. Petição 870260080213, de 10 / 08 / 2026, pág. 134 / 398 124 / 296 NO: 928 CAG00659 V1.UC55-0 GL0157646 SEQ ID NO: 929 CAG00659 O2.UC48-0 GL0022850 SEQ ID NO: 930 CAG00659 V1.UC55-O GL0065136 SEQ ID NO: 931 CAG00659 V1.UC55-0 GL0003249 SEQ ID NO: 932 CAG00659 O2.UC48-0 GL0232704 SEQ ID NO: 933 CAG00659 V1.UC55-0 GL0081417 SEQ ID NO: 934 CAG00659 V1.UC55-0 GL0120641 SEQ ID NO: 935 CAG00659 V1.UC55-0 GL0068968 SEQ ID NO: 936 CAG00659 V1.UC55-0 GL0134495 SEQ ID NO: 937 CAG00659 O2.UC48-0 GL0312586 SEQ ID NO: 938 CAG00659 V1.UC55-0 GL0136172 SEQ ID NO: 939 CAG00659 V1.UC55-0 GL0132419 SEQ ID NO: 940 CAG00659 V1.UC55-0 GL0141266 SEQ ID NO: 941 CAG00659 V1.UC55-0 GL0038453 SEQ ID NO: 942 CAG00659 O2.UC48-0 GL0001916 SEQ ID NO: 943 CAG00659 V1.UC55-0 GL0168942 SEQ ID NO: 944 CAG00659 V1.UC55-0 GL0011960 SEQ ID NO: 945 CAG00659 O2.UC48-0 GL0003471 SEQ ID NO: 946 CAG00659 V1.UC55-0 GL0028121 SEQ ID NO: 947 CAG00659 O2.UC48-0 GL0286932 SEQ ID NO: 948 CAG00659 V1.UC55-0 GL0085245 SEQ ID NO: 949 CAG00659 V1.UC55-0 GL0230349 SEQ ID NO: 950 CAG00659 V1.UC55-O GL0020063 SEQ ID NO: 951 CAG00659 V1.UC55-0 GL0185502 SEQ ID NO: 952 CAG00659 O2.UC48-0 GL0167135 SEQ ID NO: 953 CAG00659 V1.UC55-0 GL0188691 SEQ ID NO: 954 CAG00659 V1.UC55-0 GL0039924 SEQ ID NO: 955 CAG00659 O2.UC48-0 GL0301463 SEQ ID NO: 956 CAG00659 V1.UC55-0 GL0135343 SEQ ID. Petition 870260080213, dated 10 / 08 / 2026, page 135 / 398 125 / 296 NO: 957 CAG00659 O2.UC48-0 GL0045674 SEQ ID NO: 958 CAG00659 V1.UC55-0 GL0250090 SEQ ID NO: 959 CAG00659 V1.UC55-0 GL0100024 SEQ ID NO: 960 CAG00659 V1.UC55-0 GL0027986 SEQ ID NO: 961 CAG00659 V1.UC55-0 GL0144487 SEQ ID NO: 962 CAG00659 O2.UC48-0 GL0091878 SEQ ID NO: 963 CAG00659 V1.UC55-0 GL0027028 SEQ ID NO: 964 CAG00659 O2.UC48-0 GL0166121 SEQ ID NO: 965 CAG00659 V1.UC55-0 GL0002100 SEQ ID NO: 966 CAG00659 V1.UC55-0 GL0248648 SEQ ID NO: 967 CAG00659 V1.UC55-0 GL0200340 SEQ ID NO: 968 CAG00659 V1.UC55-0 GL0184665 SEQ ID NO: 969 CAG00659 V1.UC55-0 GL0206589 SEQ ID NO: 970 CAG00659 V1.UC55-0 GL0195608 SEQ ID NO: 971 CAG00659 V1.UC55-0 GL0195112 SEQ ID NO: 972 CAG00659 O2.UC48-0 GL0293274 SEQ ID NO: 973 CAG00659 V1.UC55-0 GL0148492 SEQ ID NO: 974 CAG00659 V1.UC55-0 GL0095333 SEQ ID NO: 975 CAG00659 O2.UC48-0 GL0215527 SEQ ID NO: 976 CAG00492 V1.F117 GL0043O88 SEQ ID NO: 977 CAG00492 MH0348 GL0110975 SEQ ID NO: 978 CAG00492 MH0348 GL0058897 SEQ ID NO: 979 CAG00492 MH0348 GL0129512 SEQ ID NO: 980 CAG00492 V1.CD46-0 GL0039934 SEQ ID NO: 981 CAG00492 V1.CD46-0 GL0064253 SEQ ID NO: 982 CAG00492 V1.CD46-0 GL0117608 SEQ ID NO: 983 CAG00492 V1.F108 GL0017847 SEQ ID NO: 984 CAG00492 MH0373 GL0129260 SEQ ID NO: 985 CAG00492 V1.CD46-0 GL0075229 SEQ ID. Petição 870260080213, de 10 / 08 / 2026, pág. 136 / 398 126 / 296 NO: 986 CAG00492 V1.CD46-0 GL0136740 SEQ ID NO: 987 CAG00492 MH0348 GL0008929 SEQ ID NO: 988 CAG00492 V1.CD46-0 GL0135816 SEQ ID NO: 989 CAG00492 V1.CD46-0 GL0068552 SEQ ID NO: 990 CAG00492 V1.CD46-0 GL0077963 SEQ ID NO: 991 CAG00492 MH0348 GL0074142 SEQ ID NO: 992 CAG00492 V1.F108 GL0104771 SEQ ID NO: 993 CAG00492 V1.F117 GL0153167 SEQ ID NO: 994 CAG00492 MH0348 GL0055971 SEQ ID NO: 995 CAG00492 V1.F108 GL0146851 SEQ ID NO: 996 CAG00492 V1.F108 GL0053807 SEQ ID NO: 997 CAG00492 V1.CD46-0 GL0112049 SEQ ID NO: 998 CAG00492 V1.CD46-0 GL0089014 SEQ ID NO: 999 CAG00492 MH0348 GL0053234 SEQ ID NO: 1000 CAG00492 V1.F108 GL0145379 SEQ ID NO: 1001 CAG00492 V1.F108 GL0165033 SEQ ID NO: 1002 CAG00492 V1.F108 GL0008571 SEQ ID NO: 1003 CAG00492 V1.F108 GL0166887 SEQ ID NO: 1004 CAG00492 V1.F117 GL0066347 SEQ ID NO: 1005 CAG00492 MH0348 GL0136454 SEQ ID NO: 1006 CAG00492 V1.F108 GL0087488 SEQ ID NO: 1007 CAG00492 MH0348 GL0023440 SEQ ID NO: 1008 CAG00492 V1.F108 GL0138599 SEQ ID NO: 1009 CAG00492 V1.F108 GL0073194 SEQ ID NO:. Petição 870260080213, de 10 / 08 / 2026, pág. 137 / 398 127 / 296 1010 CAG00492 V1.F108 GL0127100 SEQ ID NO: 1011 CAG00492 MH0348 GL0136728 SEQ ID NO: 1012 CAG00492 V1.F108 GL0073404 SEQ ID NO: 1013 CAG00492 MH0348 GL0118964 SEQ ID NO: 1014 CAG00492 V1.F108 GL0131066 SEQ ID NO: 1015 CAG00492 V1.F108 GL0136903 SEQ ID NO: 1016 CAG00492 V1.CD46-0 GL0141031 SEQ ID NO: 1017 CAG00492 MH0348 GL0074552 SEQ ID NO: 1018 CAG00492 MH0373 GL0093766 SEQ ID NO: 1019 CAG00492 V1.F117 GL0041765 SEQ ID NO: 1020 CAG00492 V1.F108 GL0036958 SEQ ID NO: 1021 CAG00492 V1.F108 GL0034796 SEQ ID NO: 1022 CAG00492 V1.F108 GL0141490 SEQ ID NO: 1023 CAG00492 MH0348 GL0038049 SEQ ID NO: 1024 CAG00492 V1.CD46-0 GL0006897 SEQ ID NO: 1025 CAG00492 MH0348 GL0128273 SEQ ID NO: 1026 CAG00518 V1.F117 GL0223127 SEQ ID NO: 1027 CAG00518 V1.F117 GL0056536 SEQ ID NO: 1028 CAG00518 V1.F117 GL0151283 SEQ ID NO: 1029 Petição 870260080213, de 10 / 08 / 2026, pág. 138 / 398 128 / 296 CAG00518 V1.Fl17 GL0105002 SEQ ID NO: 1030 CAG00518 V1.Fl17 GL0034777 SEQ ID NO: 1031 CAG00518 V1.F117 GL0056308 SEQ ID NO: 1032 CAG00518 V1.F117 GL0174918 SEQ ID NO: 1033 CAG00518 V1.F117 GL0222796 SEQ ID NO: 1034 CAG00518 V1.F117 GL0067073 SEQ ID NO: 1035 CAG00518 V1.F117 GL0178176 SEQ ID NO: 1036 CAG00518 V1.F117 GL01797O3 SEQ ID NO: 1037 CAG00518 V1.F117 GL0189443 SEQ ID NO: 1038 CAG00518 V1.F117 GL0084116 SEQ ID NO: 1039 CAG00518 V1.F117 GL017O320 SEQ ID NO: 1040 CAG00518 V1.F117 GL0172798 SEQ ID NO: 1041 CAG00518 V1.F117 GL0080116 SEQ ID NO: 1042 CAG00518 V1.F117 GL0064860 SEQ ID NO: 1043 CAG00518 V1.F117 GL0005908 SEQ ID NO: 1044 CAG00518 V1.F117 GL0081029 SEQ ID NO: 1045 CAG00518 V1.F117 GL0123216 SEQ ID NO: 1046 CAG00518 V1.F117 GL0049498 SEQ ID NO: 1047 CAG00518 V1.F117 GL0096107 SEQ ID NO: 1048 CAG00518 V1.F117 GL0145670 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 139 / 398 129 / 296 1049 CAG00518 V1.Fl17 GL0095433 SEQ ID NO: 1050 CAG00518 V1.Fl17 GL0098541 SEQ ID NO: 1051 CAG00518 V1.F117 GL0213327 SEQ ID NO: 1052 CAG00518 V1.F117 GL0026647 SEQ ID NO: 1053 CAG00518 V1.F117 GL0130881 SEQ ID NO: 1054 CAG00518 V1.F117 GL0119514 SEQ ID NO: 1055 CAG00518 V1.F117 GL0152624 SEQ ID NO: 1056 CAG00518 V1.F117 GL0230043 SEQ ID NO: 1057 CAG00518 V1.F117 GL0084105 SEQ ID NO: 1058 CAG00518 V1.F117 GL0054899 SEQ ID NO: 1059 CAG00518 V1.F117 GL0090574 SEQ ID NO: 1060 CAG00518 V1.F117 GL0214395 SEQ ID NO: 1061 CAG00518 V1.F117 GL0220845 SEQ ID NO: 1062 CAG00518 V1.F117 GL0050024 SEQ ID NO: 1063 CAG00518 V1.F117 GL0207008 SEQ ID NO: 1064 CAG00518 V1.F117 GL0147404 SEQ ID NO: 1065 CAG00518 V1.F117 GL0175176 SEQ ID NO: 1066 CAG00518 V1.F117 GL0023173 SEQ ID NO: 1067 CAG00518 V1.F117 GL0177478 SEQ ID NO: 1068 Petição 870260080213, de 10 / 08 / 2026, pág. 140 / 398 130 / 296 CAG00518 V1.F117 GL0061078 SEQ ID NO: 1069 CAG00518 V1.F117 GL0039499 SEQ ID NO: 1070 CAG00518 V1.F117 GL0091846 SEQ ID NO: 1071 CAG00518 V1.F117 GL0224471 SEQ ID NO: 1072 CAG00518 V1.F117 GL0118783 SEQ ID NO: 1073 CAG00518 V1.F117 GL00563O7 SEQ ID NO: 1074 CAG00518 V1.F117 GL0088351 SEQ ID NO: 1075 CAG00518 V1.F117 GL0073252 SEQ ID NO: 1076 CAG01146 V1.F128 GL0195377 SEQ ID NO: 1077 CAG01146 O2.UC49-0 GL0025609 SEQ ID NO: 1078 CAG01146 V1.UC38-4 GL0044141 SEQ ID NO: 1079 CAG01146 V1.UC38-4 GL0021935 SEQ ID NO: 1080 CAG01146 O2.UC35-1,0 GL0026285 SEQ ID NO: 1081 CAG01146 V1.F106 GL0004599 SEQ ID NO: 1082 CAG01146 V1.UC38-4 GL0034407 SEQ ID NO: 1083 CAG01146 V1.UC38-4 GL0057326 SEQ ID NO: 1084 CAG01146 O2.UC36-1,0 GL0134634 SEQ ID NO: 1085 CAG01146 V1.UC38-4 GL0088839 SEQ ID NO: 1086 CAG01146 V1.F134 GL0143132 SEQ ID NO: 1087 CAG01146 V1.UC38-0 GL0106709 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 141 / 398 131 / 296 1088 CAG01146 V1.UC38-4 GL0027899 SEQ ID NO: 1089 CAG01146 V1.F106 GL0061656 SEQ ID NO: 1090 CAG01146 O2.UC35-1,0 GL0054016 SEQ ID NO: 1091 CAG01146 V1.UC38-0 GL0104749 SEQ ID NO: 1092 CAG01146 V1.UC38-4 GL0045647 SEQ ID NO: 1093 CAG01146 V1.UC38-4 GL0072341 SEQ ID NO: 1094 CAG01146 V1.UC38-0 GL0057730 SEQ ID NO: 1095 CAG01146 V1.F128 GL0124663 SEQ ID NO: 1096 CAG01146 V1.UC38-0 GL0040549 SEQ ID NO: 1097 CAG01146 V1.F106 GL0139057 SEQ ID NO: 1098 CAG01146 O2.UC35-1,0 GL0063806 SEQ ID NO: 1099 CAG01146 V1.UC38-0 GL0149389 SEQ ID NO: 1100 CAG01146 V1.UC38-4 GL0071470 SEQ ID NO: 1101 CAG01146 V1.F106 GL0051314 SEQ ID NO: 1102 CAG01146 O2.UC35-1,0 GL0076721 SEQ ID NO: 1103 CAG01146 V1.UC38-4 GL0050715 SEQ ID NO: 1104 CAG01146 V1.F128 GL0211259 SEQ ID NO: 1105 CAG01146 V1.UC11-0 GL0036916 SEQ ID NO: 1106 CAG01146 V1.UC38-0 GL0052356 SEQ ID NO: 1107 Petição 870260080213, de 10 / 08 / 2026, pág. 142 / 398 132 / 296 CAG01146 V1.UC38-4 GL0065035 SEQ ID NO: 1108 CAG01146 O2.UC49-0 GL0018610 SEQ ID NO: 1109 CAG01146 V1.UC38-4 GL0056319 SEQ ID NO: 1110 CAG01146 O2.UC49-0 GL0158507 SEQ ID NO: 1111 CAG01146 V1.UC38-0 GL0073167 SEQ ID NO: 1112 CAG01146 O2.UC35-1,0 GL0026564 SEQ ID NO: 1113 CAG01146 V1.UC38-4 GL0006756 SEQ ID NO: 1114 CAG01146 V1.F128 GL0051866 SEQ ID NO: 1115 CAG01146 V1.UC38-0 GL0081759 SEQ ID NO: 1116 CAG01146 V1.UC11-0 GL0026546 SEQ ID NO: 1117 CAG01146 V1.UC38-4 GL0091721 SEQ ID NO: 1118 CAG01146 V1.F128 GL0206130 SEQ ID NO: 1119 CAG01146 V1.UC38-0 GL0013101 SEQ ID NO: 1120 CAG01146 V1.UC38-4 GL0061996 SEQ ID NO: 1121 CAG01146 V1.UC38-4 GL0142563 SEQ ID NO: 1122 CAG01146 V1.UC38-4 GL0156200 SEQ ID NO: 1123 CAG01146 V1.F106 GL0070368 SEQ ID NO: 1124 CAG01146 V1.UC38-4 GL0162695 SEQ ID NO: 1125 CAG01146 O2.UC11-1,0 GL0117762 SEQ ID NO: 1126 CAG00079 N017A GL0059153 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 143 / 398 133 / 296 1127 CAG00079 SZEY-1,004A GL0060090 SEQ ID NO: 1128 CAG00079 MH0020 GL0000529 SEQ ID NO: 1129 CAG00079 MH0301 GL0097161 SEQ ID NO: 1130 CAG00079 MH0006 GL0148832 SEQ ID NO: 1131 CAG00079 MH0006 GL0157059 SEQ ID NO: 1132 CAG00079 MH0087 GL0033669 SEQ ID NO: 1133 CAG00079 MH0087 GL0001927 SEQ ID NO: 1134 CAG00079 MH0006 GL0200708 SEQ ID NO: 1135 CAG00079 MH0006 GL0085266 SEQ ID NO: 1136 CAG00079 V1.CD11-0 GL0023861 SEQ ID NO: 1137 CAG00079 MH0087 GL0026189 SEQ ID NO: 1138 CAG00079 MH0020 GL0009728 SEQ ID NO: 1139 CAG00079 MH0305 GL0021042 SEQ ID NO: 1140 CAG00079 MH0087 GL0014945 SEQ ID NO: 1141 CAG00079 MH0087 GL0048780 SEQ ID NO: 1142 CAG00079 MH0087 GL0025847 SEQ ID NO: 1143 CAG00079 MH0109 GL0086398 SEQ ID NO: 1144 CAG00079 SZEY-64A GL0001256 SEQ ID NO: 1145 CAG00079 MH0006 GL0111726 SEQ ID NO: 1146 Petição 870260080213, de 10 / 08 / 2026, pág. 144 / 398 134 / 296 CAG00079 MH0420 GL0006194 SEQ ID NO: 1147 CAG00079 MH0074 GL0014285 SEQ ID NO: 1148 CAG00079 MH0006 GL0100867 SEQ ID NO: 1149 CAG00079 SZEY-78A GL0051586 SEQ ID NO: 1150 CAG00079 MH0087 GL0041527 SEQ ID NO: 1151 CAG00079 MH0274 GL0125787 SEQ ID NO: 1152 CAG00079 MH0087 GL0010722 SEQ ID NO: 1153 CAG00079 MH0006 GL0161952 SEQ ID NO: 1154 CAG00079 MH0087 GL0047637 SEQ ID NO: 1155 CAG00079 MH0166 GL0060041 SEQ ID NO: 1156 CAG00079 MH0301 GL0099557 SEQ ID NO: 1157 CAG00079 MH0109 GL0002384 SEQ ID NO: 1158 CAG00079 MH0166 GL0024801 SEQ ID NO: 1159 CAG00079 T2D-2A GL0025065 SEQ ID NO: 1160 CAG00079 MH0087 GL0018284 SEQ ID NO: 1161 CAG00079 MH0020 GL0029215 SEQ ID NO: 1162 CAG00079 MH0006 GL0081754 SEQ ID NO: 1163 CAG00079 MH0087 GL0001908 SEQ ID NO: 1164 CAG00079 MH0088 GL0109554 SEQ ID NO: 1165 CAG00079 MH0006 GL0140990 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 145 / 398 135 / 296 1166 CAG00079 MH0119 GL0032882 SEQ ID NO: 1167 CAG00079 MH0020 GL0051592 SEQ ID NO: 1168 CAG00079 MH0222 GL0069273 SEQ ID NO: 1169 CAG00079 MH0109 GL0040568 SEQ ID NO: 1170 CAG00079 MH0006 GL0159123 SEQ ID NO: 1171 CAG00079 MH0006 GL0117755 SEQ ID NO: 1172 CAG00079 T2D-1,00A GL0041736 SEQ ID NO: 1173 CAG00079 MH0020 GL0022084 SEQ ID NO: 1174 CAG00079 MH0006 GL0169081 SEQ ID NO: 1175 CAG00079 MH0020 GL0045499 SEQ ID NO: 1176 CAG00393 MH0455 GL0014920 SEQ ID NO: 1177 CAG00393 MH0010 GL0006771 SEQ ID NO: 1178 CAG00393 MH0010 GL0019638 SEQ ID NO: 1179 CAG00393 764285508- stool1 revised scaffold26788 1 gene82388 SEQ ID NO: 1180 CAG00393 MH0010 GL0008861 SEQ ID NO: 1181 CAG00393 MH0010 GL0038429 SEQ ID NO: 1182 CAG00393 MH0010 GL0039855 SEQ ID NO: 1183 CAG00393 MH0451 GL0172720 SEQ ID NO: 1184 CAG00393 O2.UC58-2 GL0156633 SEQ ID NO: 1185 Petição 870260080213, de 10 / 08 / 2026, pág. 146 / 398 136 / 296 CAG00393 MH0010 GL0035092 SEQ ID NO: 1186 CAG00393 MH0412 GL0061734 SEQ ID NO: 1187 CAG00393 MH0021 GL0029491 SEQ ID NO: 1188 CAG00393 MH0010 GL0027185 SEQ ID NO: 1189 CAG00393 MH0076 GL0069584 SEQ ID NO: 1190 CAG00393 MH0076 GL0023849 SEQ ID NO: 1191 CAG00393 MH0010 GL0004096 SEQ ID NO: 1192 CAG00393 MH0010 GL0043784 SEQ ID NO: 1193 CAG00393 MH0010 GL0039245 SEQ ID NO: 1194 CAG00393 O2.UC40-1,0 GL0172758 SEQ ID NO: 1195 CAG00393 MH0010 GL0000174 SEQ ID NO: 1196 CAG00393 MH0010 GL0044855 SEQ ID NO: 1197 CAG00393 MH0010 GL0016776 SEQ ID NO: 1198 CAG00393 MH0010 GL0017732 SEQ ID NO: 1199 CAG00393 T2D-54A GL0005082 SEQ ID NO: 1200 CAG00393 MH0010 GL0007485 SEQ ID NO: 1201 CAG00393 DLM008 GL0038553 SEQ ID NO: 1202 CAG00393 MH0345 GL0003914 SEQ ID NO: 1203 CAG00393 MH0010 GL0018041 SEQ ID NO: 1204 CAG00393 MH0010 GL0029248 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 147 / 398 137 / 296 1205 CAG00393 MH0316 GL0156730 SEQ ID NO: 1206 CAG00393 O2.UC14-2 GL0059182 SEQ ID NO: 1207 CAG00393 NLF013 GL0025166 SEQ ID NO: 1208 CAG00393 T2D-1,049A GL0031274 SEQ ID NO: 1209 CAG00393 MH0148 GL0152134 SEQ ID NO: 1210 CAG00393 MH0224 GL0195949 SEQ ID NO: 1211 CAG00393 MH0454 GL0222405 SEQ ID NO: 1212 CAG00393 MH0094 GL0112338 SEQ ID NO: 1213 CAG00393 MH0010 GL0011210 SEQ ID NO: 1214 CAG00393 MH0010 GL0028548 SEQ ID NO: 1215 CAG00393 MH0010 GL0015291 SEQ ID NO: 1216 CAG00393 MH0345 GL0126419 SEQ ID NO: 1217 CAG00393 O2.UC14-2 GL0085563 SEQ ID NO: 1218 CAG00393 NOF008 GL0002843 SEQ ID NO: 1219 CAG00393 MH0234 GL0001308 SEQ ID NO: 1220 CAG00393 MH0010 GL0029233 SEQ ID NO: 1221 CAG00393 MH0115 GL0015508 SEQ ID NO: 1222 CAG00393 MH0010 GL0035190 SEQ ID NO: 1223 CAG00393 MH0010 GL0017083 SEQ ID NO: 1224 Petição 870260080213, de 10 / 08 / 2026, pág. 148 / 398 138 / 296 CAG00393 MH0276 GL0232709 SEQ ID NO: 1225 CAG00393 MH0021 GL0021690 SEQ ID NO: 1226 CAG00766 763901136- stool 1 revised scaffold 25610 1 gene21731 SEQ ID NO: 1227 CAG00766 MH0012 GL0082825 SEQ ID NO: 1228 CAG00766 MH0012 GL0213577 SEQ ID NO: 1229 CAG00766 MH0224 GL0006730 SEQ ID NO: 1230 CAG00766 MH0012 GL0215773 SEQ ID NO: 1231 CAG00766 MH0142 GL0028426 SEQ ID NO: 1232 CAG00766 MH0118 GL0100408 SEQ ID NO: 1233 CAG00766 MH0185 GL0091951 SEQ ID NO: 1234 CAG00766 MH0012 GL0000190 SEQ ID NO: 1235 CAG00766 MH0438 GL0006701 SEQ ID NO: 1236 CAG00766 MH0280 GL0150979 SEQ ID NO: 1237 CAG00766 MH0012 GL0069123 SEQ ID NO: 1238 CAG00766 MH0053 GL0026412 SEQ ID NO: 1239 CAG00766 MH0012 GL0226816 SEQ ID NO: 1240 CAG00766 765701615- stool1 revised scaffold24399 1 gene45416 SEQ ID NO: 1241 CAG00766 MH0117 GL0073357 SEQ ID NO: 1242 CAG00766 MH0142 GL0001380 SEQ ID NO: 1243 CAG00766 MH0378 GL0128532 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 149 / 398 139 / 296 1244 CAG00766 MH0329 GL0162954 SEQ ID NO: 1245 CAG00766 MH0004 GL0025979 SEQ ID NO: 1246 CAG00766 MH0012 GL0129416 SEQ ID NO: 1247 CAG00766 MH0012 GL0070480 SEQ ID NO: 1248 CAG00766 MH0446 GL0199336 SEQ ID NO: 1249 CAG00766 O2.UC47-1,0 GL0073293 SEQ ID NO: 1250 CAG00766 O2.UC57-0 GL0047837 SEQ ID NO: 1251 CAG00766 MH0142 GL0077412 SEQ ID NO: 1252 CAG00766 MH0204 GL0111428 SEQ ID NO: 1253 CAG00766 MH0104 GL0101995 SEQ ID NO: 1254 CAG00766 MH0220 GL0102755 SEQ ID NO: 1255 CAG00766 MH0144 GL0113742 SEQ ID NO: 1256 CAG00766 MH0454 GL0245294 SEQ ID NO: 1257 CAG00766 V1.Fl14 GL0156O93 SEQ ID NO: 1258 CAG00766 V1.Fl07 GL0136264 SEQ ID NO: 1259 CAG00766 MH0006 GL0193781 SEQ ID NO: 1260 CAG00766 MH0012 GL0200508 SEQ ID NO: 1261 CAG00766 MH0012 GL0166994 SEQ ID NO: 1262 CAG00766 MH0012 GL0228079 SEQ ID NO: 1263 Petição 870260080213, de 10 / 08 / 2026, pág. 150 / 398 140 / 296 CAG00766 MH0383 GL0051378 SEQ ID NO: 1264 CAG00766 MH0193 GL0073874 SEQ ID NO: 1265 CAG00766 MH0012 GL0082824 SEQ ID NO: 1266 CAG00766 MH0193 GL0027357 SEQ ID NO: 1267 CAG00766 O2.UC13-2 GL0031768 SEQ ID NO: 1268 CAG00766 O2.UC40-1,0 GL0192463 SEQ ID NO: 1269 CAG00766 MH0394 GL0042591 SEQ ID NO: 1270 CAG00766 MH0012 GL0031924 SEQ ID NO: 1271 CAG00766 MH0229 GL0107290 SEQ ID NO: 1272 CAG00766 O2.UC47-1,0 GL0095795 SEQ ID NO: 1273 CAG00766 MH0220 GL0074700 SEQ ID NO: 1274 CAG00766 MH0117 GL0107140 SEQ ID NO: 1275 CAG00766 MH0272 GL0100309 SEQ ID NO: 1276 CAG00095 MH0089 GL0046375 SEQ ID NO: 1277 CAG00095 O2.UC28-0 GL0179744 SEQ ID NO: 1278 CAG00095 MH0066 GL0040803 SEQ ID NO: 1279 CAG00095 MH0089 GL0043771 SEQ ID NO: 1280 CAG00095 MH0182 GL0033199 SEQ ID NO: 1281 CAG00095 MH0066 GL0054638 SEQ ID NO: 1282 CAG00095 MH0089 GL0066960 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 151 / 398 141 / 296 1283 CAG00095 MH0262 GL0027791 SEQ ID NO: 1284 CAG00095 N034A GL0043072 SEQ ID NO: 1285 CAG00095 N037A GL0059379 SEQ ID NO: 1286 CAG00095 MH0089 GL0002779 SEQ ID NO: 1287 CAG00095 763840445- stool2 revised scaffold52492 2 gene169926 SEQ ID NO: 1288 CAG00095 MH0089 GL0064602 SEQ ID NO: 1289 CAG00095 MH0089 GL0047899 SEQ ID NO: 1290 CAG00095 MH0089 GL0107661 SEQ ID NO: 1291 CAG00095 O2.UC50-0 GL0090229 SEQ ID NO: 1292 CAG00095 MH0089 GL0032534 SEQ ID NO: 1293 CAG00095 MH0089 GL0108397 SEQ ID NO: 1294 CAG00095 MH0066 GL0054655 SEQ ID NO: 1295 CAG00095 MH0089 GL0074632 SEQ ID NO: 1296 CAG00095 159247771-stool1 revised C643738 1 gene47371 SEQ ID NO: 1297 CAG00095 MH0343 GL0066333 SEQ ID NO: 1298 CAG00095 MH0089 GL0067108 SEQ ID NO: 1299 CAG00095 764588959-stool1 revised C754420 1 gene104384 SEQ ID NO: 1300 CAG00095 MH0089 GL0056811 SEQ ID NO: 1301 CAG00095 MH0089 GL0099404 SEQ ID NO: 1302 Petição 870260080213, de 10 / 08 / 2026, pág. 152 / 398 142 / 296 CAG00095 V1.CD2-0-PT GL0013676 SEQ ID NO: 1303 CAG00095 MH0262 GL0119556 SEQ ID NO: 1304 CAG00095 MH0089 GL0013544 SEQ ID NO: 1305 CAG00095 764184357- stool1 revised scaffold 1841 11 gene 14991 SEQ ID NO: 1306 CAG00095 MH0182 GL0006395 SEQ ID NO: 1307 CAG00095 MH0182 GL0048904 SEQ ID NO: 1308 CAG00095 158944319- stool1 revised scaffold26376 1 gene108987 SEQ ID NO: 1309 CAG00095 MH0395 GL0116427 SEQ ID NO: 1310 CAG00095 MH0262 GL0046339 SEQ ID NO: 1311 CAG00095 MH0182 GL0017395 SEQ ID NO: 1312 CAG00095 MH0182 GL0056494 SEQ ID NO: 1313 CAG00095 MH0262 GL0136800 SEQ ID NO: 1314 CAG00095 MH0089 GL0013064 SEQ ID NO: 1315 CAG00095 MH0437 GL0086387 SEQ ID NO: 1316 CAG00095 V1.CD2-0-PT GL0041810 SEQ ID NO: 1317 CAG00095 MH0089 GL0055816 SEQ ID NO: 1318 CAG00095 V1.Fl16 GL0098417 SEQ ID NO: 1319 CAG00095 MH0089 GL0074324 SEQ ID NO: 1320 CAG00095 MH0182 GL0040920 SEQ ID NO: 1321 CAG00095 DLF004 GL0024691 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 153 / 398 143 / 296 1322 CAG00095 N038A GL0029176 SEQ ID NO: 1323 CAG00095 MH0089 GL0034070 SEQ ID NO: 1324 CAG00095 V1.CD2-0-PT GL0091669 SEQ ID NO: 1325 CAG00095 MH0437 GL0249840 SEQ ID NO: 1326 CAG00010 1 MH0217 GL0019688 SEQ ID NO: 1327 CAG00010 1 MH0217 GL0077941 SEQ ID NO: 1328 CAG00010 1 MH0217 GL0131423 SEQ ID NO: 1329 CAG00010 1 MH0217 GL0149562 SEQ ID NO: 1330 CAG00010 1 MH0217 GL0100632 SEQ ID NO: 1331 CAG00010 1 MH0217 GL0025975 SEQ ID NO: 1332 CAG00010 1 MH0217 GL0126762 SEQ ID NO: 1333 CAG00010 1 MH0217 GL0169704 SEQ ID NO: 1334 CAG00010 1 MH0217 GL0176618 SEQ ID NO: 1335 CAG00010 1 MH0217 GL0178868 SEQ ID NO: 1336 CAG00010 1 MH0217 GL0180478 SEQ ID NO: 1337 CAG00010 1 MH0217 GL0126187 SEQ ID NO: 1338 CAG00010 1 MH0217 GL0178866 SEQ ID NO: 1339 CAG00010 1 MH0217 GL0052006 SEQ ID NO: 1340 CAG00010 1 MH0217 GL0061698 SEQ ID NO: 1341 Petição 870260080213, de 10 / 08 / 2026, pág. 154 / 398 144 / 296 CAG00010 1 MH0217 GL0022762 SEQ ID NO: 1342 CAG00010 1 MH0217 GL0019681 SEQ ID NO: 1343 CAG00010 1 MH0217 GL0027380 SEQ ID NO: 1344 CAG00010 1 MH0217 GL0123421 SEQ ID NO: 1345 CAG00010 1 MH0217 GL0013322 SEQ ID NO: 1346 CAG00010 1 MH0217 GL0060985 SEQ ID NO: 1347 CAG00010 1 MH0217 GL0126419 SEQ ID NO: 1348 CAG00010 1 MH0217 GL0065183 SEQ ID NO: 1349 CAG00010 1 MH0217 GL0061898 SEQ ID NO: 1350 CAG00010 1 MH0217 GL0049289 SEQ ID NO: 1351 CAG00010 1 MH0217 GL0002063 SEQ ID NO: 1352 CAG00010 1 MH0217 GL0018343 SEQ ID NO: 1353 CAG00010 1 MH0217 GL0038438 SEQ ID NO: 1354 CAG00010 1 MH0217 GL0004399 SEQ ID NO: 1355 CAG00010 1 MH0217 GL0145674 SEQ ID NO: 1356 CAG00010 1 MH0217 GL0176617 SEQ ID NO: 1357 CAG00010 1 MH0217 GL0105375 SEQ ID NO: 1358 CAG00010 1 MH0217 GL0052153 SEQ ID NO: 1359 CAG00010 1 MH0217 GL0052144 SEQ ID NO: 1360 CAG00010 1 MH0217 GL0146664 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 155 / 398 145 / 296 1361 CAG00010 1 MH0217 GL0025977 SEQ ID NO: 1362 CAG00010 1 MH0217 GL0147606 SEQ ID NO: 1363 CAG00010 1 MH0217 GL0154145 SEQ ID NO: 1364 CAG00010 1 MH0217 GL0152825 SEQ ID NO: 1365 CAG00010 1 MH0217 GL0062706 SEQ ID NO: 1366 CAG00010 1 MH0217 GL0160566 SEQ ID NO: 1367 CAG00010 1 MH0217 GL0059626 SEQ ID NO: 1368 CAG00010 1 MH0217 GL0127172 SEQ ID NO: 1369 CAG00010 1 MH0217 GL0131064 SEQ ID NO: 1370 CAG00010 1 MH0217 GL0070524 SEQ ID NO: 1371 CAG00010 1 MH0217 GL0117215 SEQ ID NO: 1372 CAG00010 1 MH0217 GL0163595 SEQ ID NO: 1373 CAG00010 1 MH0217 GL0035863 SEQ ID NO: 1374 CAG00010 1 MH0217 GL0183396 SEQ ID NO: 1375 CAG00010 1 MH0217 GL0127175 SEQ ID NO: 1376 CAG00342 MH0230 GL0150634 SEQ ID NO: 1377 CAG00342 547043.BIFPSEUDO 02724 SEQ ID NO: 1378 CAG00342 MH0356 GL0195431 SEQ ID NO: 1379 CAG00342 MH0356 GL0045072 SEQ ID NO: 1380 Petição 870260080213, de 10 / 08 / 2026, pág. 156 / 398 146 / 296 CAG00342 V1.CD7-4 GL0062303 SEQ ID NO: 1381 CAG00342 MH0206 GL0250797 SEQ ID NO: 1382 CAG00342 MH0327 GL0032691 SEQ ID NO: 1383 CAG00342 O2.UC26-0 GL0000164 SEQ ID NO: 1384 CAG00342 MH0230 GL0066319 SEQ ID NO: 1385 CAG00342 547043.BIFPSEUDO 03586 SEQ ID NO: 1386 CAG00342 O2.UC50-2 GL0080535 SEQ ID NO: 1387 CAG00342 T2D-51A GL0104197 SEQ ID NO: 1388 CAG00342 MH0440 GL0182133 SEQ ID NO: 1389 CAG00342 MH0230 GL0057594 SEQ ID NO: 1390 CAG00342 MH0356 GL0185430 SEQ ID NO: 1391 CAG00342 MH0206 GL0011184 SEQ ID NO: 1392 CAG00342 ED19A GL0013066 SEQ ID NO: 1393 CAG00342 ED50A GL0042638 SEQ ID NO: 1394 CAG00342 V1.UC42-0 GL0042202 SEQ ID NO: 1395 CAG00342 T2D-26A GL0091258 SEQ ID NO: 1396 CAG00342 V1.F101 GL0085884 SEQ ID NO: 1397 CAG00342 547043.BIFPSEUDO 04297 SEQ ID NO: 1398 CAG00342 MH0410 GL0081324 SEQ ID NO: 1399 CAG00342 MH0356 GL0171913 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 157 / 398 147 / 296 1400 CAG00342 BGI-06A GL0016424 SEQ ID NO: 1401 CAG00342 V1.UC37-O GL0033386 SEQ ID NO: 1402 CAG00342 V1.F119 GL00293O4 SEQ ID NO: 1403 CAG00342 MH0410 GL0116975 SEQ ID NO: 1404 CAG00342 MH0230 GL0150631 SEQ ID NO: 1405 CAG00342 MH0440 GL0194775 SEQ ID NO: 1406 CAG00342 V1.CD51-0 GL0182145 SEQ ID NO: 1407 CAG00342 O2.UC19-1,0 GL0006286 SEQ ID NO: 1408 CAG00342 547043.BIFPSEUDO 02929 SEQ ID NO: 1409 CAG00342 MH0356 GL0168645 SEQ ID NO: 1410 CAG00342 V1.UC42-0 GL0019213 SEQ ID NO: 1411 CAG00342 T2D-42A GL0082631 SEQ ID NO: 1412 CAG00342 MH0356 GL0141025 SEQ ID NO: 1413 CAG00342 MH0327 GL0080409 SEQ ID NO: 1414 CAG00342 DOF008 GL0012509 SEQ ID NO: 1415 CAG00342 V1.CD2-0-PT GL0009310 SEQ ID NO: 1416 CAG00342 MH0230 GL0041022 SEQ ID NO: 1417 CAG00342 MH0230 GL0041821 SEQ ID NO: 1418 CAG00342 MH0327 GL0110337 SEQ ID NO: 1419 Petição 870260080213, de 10 / 08 / 2026, pág. 158 / 398 148 / 296 CAG00342 MH0230 GL0144175 SEQ ID NO: 1420 CAG00342 MH0230 GL0087113 SEQ ID NO: 1421 CAG00342 MH0356 GL0133287 SEQ ID NO: 1422 CAG00342 MH0327 GL0115075 SEQ ID NO: 1423 CAG00342 MH0230 GL0122733 SEQ ID NO: 1424 CAG00342 MH0356 GL0133291 SEQ ID NO: 1425 CAG00342 547043.BIFPSEUDO 04379 SEQ ID NO: 1426 CAG00303 MH0345 GL0025069 SEQ ID NO: 1427 CAG00303 MH0277 GL0043561 SEQ ID NO: 1428 CAG00303 MH0277 GL0017994 SEQ ID NO: 1429 CAG00303 MH0277 GL0035656 SEQ ID NO: 1430 CAG00303 MH0345 GL0168665 SEQ ID NO: 1431 CAG00303 MH0277 GL0005474 SEQ ID NO: 1432 CAG00303 MH0277 GL0014131 SEQ ID NO: 1433 CAG00303 MH0345 GL0161902 SEQ ID NO: 1434 CAG00303 MH0277 GL0045721 SEQ ID NO: 1435 CAG00303 V1.UC32-0 GL0068347 SEQ ID NO: 1436 CAG00303 MH0277 GL0015253 SEQ ID NO: 1437 CAG00303 MH0277 GL0027237 SEQ ID NO: 1438 CAG00303 MH0277 GL0030721 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 159 / 398 149 / 296 1439 CAG00303 MH0277 GL0037357 SEQ ID NO: 1440 CAG00303 MH0277 GL0033151 SEQ ID NO: 1441 CAG00303 MH0277 GL0047657 SEQ ID NO: 1442 CAG00303 MH0277 GL0042255 SEQ ID NO: 1443 CAG00303 MH0277 GL0001264 SEQ ID NO: 1444 CAG00303 MH0345 GL0051193 SEQ ID NO: 1445 CAG00303 MH0277 GL0027760 SEQ ID NO: 1446 CAG00303 MH0277 GL0037876 SEQ ID NO: 1447 CAG00303 MH0277 GL0043562 SEQ ID NO: 1448 CAG00303 MH0277 GL0022738 SEQ ID NO: 1449 CAG00303 MH0277 GL0025210 SEQ ID NO: 1450 CAG00303 V1.UC22-1,0 GL0059013 SEQ ID NO: 1451 CAG00303 V1.UC22-1,0 GL0009470 SEQ ID NO: 1452 CAG00303 MH0277 GL0033800 SEQ ID NO: 1453 CAG00303 MH0277 GL0021102 SEQ ID NO: 1454 CAG00303 MH0277 GL0013995 SEQ ID NO: 1455 CAG00303 MH0277 GL0044358 SEQ ID NO: 1456 CAG00303 MH0277 GL0010535 SEQ ID NO: 1457 CAG00303 MH0277 GL0000564 SEQ ID NO: 1458 Petição 870260080213, de 10 / 08 / 2026, pág. 160 / 398 150 / 296 CAG00303 MH0277 GL0054679 SEQ ID NO: 1459 CAG00303 MH0345 GL0148022 SEQ ID NO: 1460 CAG00303 MH0277 GL0009451 SEQ ID NO: 1461 CAG00303 MH0277 GL0018866 SEQ ID NO: 1462 CAG00303 MH0277 GL0002843 SEQ ID NO: 1463 CAG00303 MH0277 GL0014642 SEQ ID NO: 1464 CAG00303 MH0277 GL0052775 SEQ ID NO: 1465 CAG00303 V1.CD19-0 GL0089683 SEQ ID NO: 1466 CAG00303 MH0277 GL0002630 SEQ ID NO: 1467 CAG00303 V1.UC32-O GL016O339 SEQ ID NO: 1468 CAG00303 MH0277 GL0037875 SEQ ID NO: 1469 CAG00303 MH0277 GL0026333 SEQ ID NO: 1470 CAG00303 MH0277 GL0033234 SEQ ID NO: 1471 CAG00303 MH0277 GL0002101 SEQ ID NO: 1472 CAG00303 MH0277 GL0055650 SEQ ID NO: 1473 CAG00303 MH0345 GL0085012 SEQ ID NO: 1474 CAG00303 MH0345 GL0140542 SEQ ID NO: 1475 CAG00303 MH0277 GL0026993 SEQ ID NO: 1476 CAG00337 MH0212 GL0140047 SEQ ID NO: 1477 CAG00337 MH0212 GL0034625 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 161 / 398 151 / 296 1478 CAG00337 MH0088 GL0006484 SEQ ID NO: 1479 CAG00337 V1.F113 GL0016516 SEQ ID NO: 1480 CAG00337 MH0212 GL0131896 SEQ ID NO: 1481 CAG00337 MH0088 GL0029891 SEQ ID NO: 1482 CAG00337 MH0212 GL0104669 SEQ ID NO: 1483 CAG00337 MH0212 GL0007141 SEQ ID NO: 1484 CAG00337 MH0088 GL0118880 SEQ ID NO: 1485 CAG00337 MH0212 GL0034404 SEQ ID NO: 1486 CAG00337 MH0212 GL0008981 SEQ ID NO: 1487 CAG00337 MH0088 GL0075588 SEQ ID NO: 1488 CAG00337 MH0212 GL0168155 SEQ ID NO: 1489 CAG00337 MH0212 GL0016239 SEQ ID NO: 1490 CAG00337 V1.F113 GL015OO99 SEQ ID NO: 1491 CAG00337 V1.F113 GL0005226 SEQ ID NO: 1492 CAG00337 MH0088 GL0056538 SEQ ID NO: 1493 CAG00337 MH0088 GL0064137 SEQ ID NO: 1494 CAG00337 MH0212 GL0131813 SEQ ID NO: 1495 CAG00337 MH0212 GL0094592 SEQ ID NO: 1496 CAG00337 MH0212 GL0150396 SEQ ID NO: 1497 Petição 870260080213, de 10 / 08 / 2026, pág. 162 / 398 152 / 296 CAG00337 MH0212 GL0007716 SEQ ID NO: 1498 CAG00337 MH0358 GL0041328 SEQ ID NO: 1499 CAG00337 V1.Fl13 GL006972O SEQ ID NO: 1500 CAG00337 MH0212 GL0119553 SEQ ID NO: 1501 CAG00337 MH0358 GL0051225 SEQ ID NO: 1502 CAG00337 MH0212 GL0161055 SEQ ID NO: 1503 CAG00337 MH0212 GL0034621 SEQ ID NO: 1504 CAG00337 MH0212 GL0124894 SEQ ID NO: 1505 CAG00337 MH0212 GL0140315 SEQ ID NO: 1506 CAG00337 MH0212 GL0120377 SEQ ID NO: 1507 CAG00337 V1.F113 GL0107233 SEQ ID NO: 1508 CAG00337 MH0212 GL0024275 SEQ ID NO: 1509 CAG00337 V1.F111 GL0100921 SEQ ID NO: 1510 CAG00337 MH0212 GL0049197 SEQ ID NO: 1511 CAG00337 MH0088 GL0131171 SEQ ID NO: 1512 CAG00337 V1.F111 GL0025056 SEQ ID NO: 1513 CAG00337 MH0212 GL0039936 SEQ ID NO: 1514 CAG00337 MH0212 GL0016237 SEQ ID NO: 1515 CAG00337 MH0088 GL0111816 SEQ ID NO: 1516 CAG00337 MH0212 GL0090580 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 163 / 398 153 / 296 1517 CAG00337 MH0212 GL0133270 SEQ ID NO: 1518 CAG00337 MH0212 GL0084814 SEQ ID NO: 1519 CAG00337 MH0088 GL0080625 SEQ ID NO: 1520 CAG00337 MH0212 GL0126560 SEQ ID NO: 1521 CAG00337 MH0088 GL0010923 SEQ ID NO: 1522 CAG00337 MH0358 GL0044332 SEQ ID NO: 1523 CAG00337 MH0212 GL0030833 SEQ ID NO: 1524 CAG00337 MH0088 GL0100711 SEQ ID NO: 1525 CAG00337 MH0212 GL0036263 SEQ ID NO: 1526 CAG00381 MH0233 GL0095998 SEQ ID NO: 1527 CAG00381 MH0233 GL0113533 SEQ ID NO: 1528 CAG00381 MH0233 GL0113359 SEQ ID NO: 1529 CAG00381 MH0233 GL0065305 SEQ ID NO: 1530 CAG00381 MH0233 GL0117231 SEQ ID NO: 1531 CAG00381 MH0233 GL0113826 SEQ ID NO: 1532 CAG00381 MH0233 GL0065304 SEQ ID NO: 1533 CAG00381 MH0233 GL0003883 SEQ ID NO: 1534 CAG00381 MH0233 GL0028807 SEQ ID NO: 1535 CAG00381 MH0233 GL0028855 SEQ ID NO: 1536 Petição 870260080213, de 10 / 08 / 2026, pág. 164 / 398 154 / 296 CAG00381 MH0233 GL0091862 SEQ ID NO: 1537 CAG00381 MH0233 GL0113327 SEQ ID NO: 1538 CAG00381 MH0233 GL0119203 SEQ ID NO: 1539 CAG00381 O2.UC48-0 GL0255960 SEQ ID NO: 1540 CAG00381 MH0233 GL0030526 SEQ ID NO: 1541 CAG00381 O2.UC19-2 GL0100874 SEQ ID NO: 1542 CAG00381 MH0233 GL0063420 SEQ ID NO: 1543 CAG00381 O2.UC19-2 GL0003982 SEQ ID NO: 1544 CAG00381 MH0233 GL0095983 SEQ ID NO: 1545 CAG00381 MH0233 GL0056899 SEQ ID NO: 1546 CAG00381 O2.UC36-0 GL0021124 SEQ ID NO: 1547 CAG00381 MH0233 GL0011731 SEQ ID NO: 1548 CAG00381 MH0233 GL0082238 SEQ ID NO: 1549 CAG00381 MH0233 GL0113355 SEQ ID NO: 1550 CAG00381 MH0358 GL0105021 SEQ ID NO: 1551 CAG00381 MH0233 GL0007569 SEQ ID NO: 1552 CAG00381 O2.UC36-0 GL0058223 SEQ ID NO: 1553 CAG00381 MH0233 GL0060185 SEQ ID NO: 1554 CAG00381 MH0233 GL0066846 SEQ ID NO: 1555 CAG00381 MH0233 GL0091186 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 165 / 398 155 / 296 1556 CAG00381 MH0233 GL0052995 SEQ ID NO: 1557 CAG00381 MH0233 GL0103619 SEQ ID NO: 1558 CAG00381 MH0233 GL0056698 SEQ ID NO: 1559 CAG00381 O2.UC11-1,0 GL0112377 SEQ ID NO: 1560 CAG00381 MH0233 GL0019862 SEQ ID NO: 1561 CAG00381 MH0233 GL0103622 SEQ ID NO: 1562 CAG00381 MH0233 GL0091850 SEQ ID NO: 1563 CAG00381 O2.UC19-2 GL0008363 SEQ ID NO: 1564 CAG00381 MH0233 GL0059183 SEQ ID NO: 1565 CAG00381 MH0233 GL0091864 SEQ ID NO: 1566 CAG00381 MH0233 GL0010836 SEQ ID NO: 1567 CAG00381 MH0233 GL0056907 SEQ ID NO: 1568 CAG00381 MH0233 GL0035462 SEQ ID NO: 1569 CAG00381 MH0233 GL0090705 SEQ ID NO: 1570 CAG00381 V1.Fl04 GL0104012 SEQ ID NO: 1571 CAG00381 MH0233 GL0066852 SEQ ID NO: 1572 CAG00381 MH0233 GL0047497 SEQ ID NO: 1573 CAG00381 V1.F112 GL0203479 SEQ ID NO: 1574 CAG00381 MH0233 GL0077085 SEQ ID NO: 1575 Petição 870260080213, de 10 / 08 / 2026, pág. 166 / 398 156 / 296 CAG00381 MH0233 GL0091179 SEQ ID NO: 1576 CAG00559 MH0012 GL0066180 SEQ ID NO: 1577 CAG00559 MH0012 GL0237518 SEQ ID NO: 1578 CAG00559 O2.UC52-2 GL0048590 SEQ ID NO: 1579 CAG00559 158944319-stool1 revised C1045997 1 gene109890 SEQ ID NO: 1580 CAG00559 MH0012 GL0074963 SEQ ID NO: 1581 CAG00559 160704339-stool1 revised C1411799 1 gene84313 SEQ ID NO: 1582 CAG00559 O2.UC47-1,0 GL0019033 SEQ ID NO: 1583 CAG00559 MH0373 GL0172307 SEQ ID NO: 1584 CAG00559 MH0453 GL0132208 SEQ ID NO: 1585 CAG00559 MH0012 GL0128724 SEQ ID NO: 1586 CAG00559 MH0252 GL0186374 SEQ ID NO: 1587 CAG00559 MH0012 GL0090850 SEQ ID NO: 1588 CAG00559 MH0012 GL0117901 SEQ ID NO: 1589 CAG00559 MH0012 GL0103293 SEQ ID NO: 1590 CAG00559 MH0012 GL0165258 SEQ ID NO: 1591 CAG00559 MH0012 GL0234812 SEQ ID NO: 1592 CAG00559 MH0422 GL0099033 SEQ ID NO: 1593 CAG00559 MH0012 GL0212617 SEQ ID NO: 1594 CAG00559 MH0012 GL0036355 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 167 / 398 157 / 296 1595 CAG00559 MH0356 GL0155940 SEQ ID NO: 1596 CAG00559 MH0193 GL0127486 SEQ ID NO: 1597 CAG00559 MH0262 GL0099379 SEQ ID NO: 1598 CAG00559 O2.UC47-1,0 GL0011868 SEQ ID NO: 1599 CAG00559 MH0206 GL0124420 SEQ ID NO: 1600 CAG00559 SZEY-62A GL0068587 SEQ ID NO: 1601 CAG00559 MH0343 GL0006001 SEQ ID NO: 1602 CAG00559 MH0096 GL0061137 SEQ ID NO: 1603 CAG00559 O2.UC40-1,0 GL0194629 SEQ ID NO: 1604 CAG00559 MH0012 GL0117904 SEQ ID NO: 1605 CAG00559 MH0200 GL0191918 SEQ ID NO: 1606 CAG00559 MH0012 GL0029892 SEQ ID NO: 1607 CAG00559 N022A GL0074028 SEQ ID NO: 1608 CAG00559 V1.CD30-0 GL0091931 SEQ ID NO: 1609 CAG00559 V1.CD6-0-PT GL0145486 SEQ ID NO: 1610 CAG00559 MH0303 GL0078484 SEQ ID NO: 1611 CAG00559 MH0197 GL0156714 SEQ ID NO: 1612 CAG00559 MH0434 GL0122412 SEQ ID NO: 1613 CAG00559 MH0012 GL0108748 SEQ ID NO: 1614 Petição 870260080213, de 10 / 08 / 2026, pág. 168 / 398 158 / 296 CAG00559 MH0012 GL0090852 SEQ ID NO: 1615 CAG00559 MH0012 GL0237521 SEQ ID NO: 1616 CAG00559 MH0193 GL0073226 SEQ ID NO: 1617 CAG00559 SZEY-62A GL0048973 SEQ ID NO: 1618 CAG00559 MH0193 GL0045020 SEQ ID NO: 1619 CAG00559 MH0430 GL0114903 SEQ ID NO: 1620 CAG00559 MH0197 GL0045605 SEQ ID NO: 1621 CAG00559 MH0012 GL0119351 SEQ ID NO: 1622 CAG00559 MH0197 GL0122038 SEQ ID NO: 1623 CAG00559 MH0012 GL0050082 SEQ ID NO: 1624 CAG00559 MH0012 GL0103291 SEQ ID NO: 1625 CAG00559 MH0451 GL0204212 SEQ ID NO: 1626 CAG00570 158337416-stool1 revised C1240234 1 gene61382 SEQ ID NO: 1627 CAG00570 MH0366 GL0014438 SEQ ID NO: 1628 CAG00570 MH0366 GL0105096 SEQ ID NO: 1629 CAG00570 MH0366 GL0142970 SEQ ID NO: 1630 CAG00570 158337416-stooll revised C1228438 1 gene210576 SEQ ID NO: 1631 CAG00570 158337416-stooll revised C1139104 1 gene171934 SEQ ID NO: 1632 CAG00570 158337416-stool1 revised C1162436 1 gene157074 SEQ ID NO: 1633 CAG00570 158337416- stool1 revised scaffold16772 1 gene138838 SEQ ID NO: Petition 870260080213, dated 10 / 08 / 2026, p. 169 / 398 159 / 296 1634 CAG00570 158337416-stool1 revised C1269936 1 gene164544 SEQ ID NO: 1635 CAG00570 158337416-stool1 revised C1225906 1 gene110954 SEQ ID NO: 1636 CAG00570 160704339- stooll revised scaffold28351 1 gene137089 SEQ ID NO: 1637 CAG00570 MH0366 GL0132869 SEQ ID NO: 1638 CAG00570 MH0366 GL0070438 SEQ ID NO: 1639 CAG00570 MH0366 GL0046120 SEQ ID NO: 1640 CAG00570 158337416- stool1 revised scaffold19851 1 gene97170 SEQ ID NO: 1641 CAG00570 158337416-stool1 revised C1149190 1 gene133843 SEQ ID NO: 1642 CAG00570 158337416-stool1 revised C1203284 1 gene113710 SEQ ID NO: 1643 CAG00570 MH0366 GL0009017 SEQ ID NO: 1644 CAG00570 MH0366 GL0127883 SEQ ID NO: 1645 CAG00570 158337416- stool1 revised scaffold7598 1 gene91220 SEQ ID NO: 1646 CAG00570 MH0366 GL0078392 SEQ ID NO: 1647 CAG00570 158337416- stool1 revised scaffold24453 1 gene65737 SEQ ID NO: 1648 CAG00570 MH0366 GL0125454 SEQ ID NO: 1649 CAG00570 158337416-stool1 revised C1254876 1 gene205094 SEQ ID NO: 1650 CAG00570 158337416- stool1revised scaffold9058 1 gene230576 SEQ ID NO: 1651 CAG00570 MH0366 GL0089956 SEQ ID NO: 1652 CAG00570 MH0366 GL0066569 SEQ ID NO: 1653 Petição 870260080213, de 10 / 08 / 2026, pág. 170 / 398 160 / 296 CAG00570 158337416- stooll revised scaffold22387 1 gene164973 SEQ ID NO: 1654 CAG00570 158337416- stool1 revised scaffold22730 1 gene129709 SEQ ID NO: 1655 CAG00570 158337416- stool1 revised scaffold1855 1 gene49512 SEQ ID NO: 1656 CAG00570 MH0366 GL0141852 SEQ ID NO: 1657 CAG00570 160704339-stool1 revised C1327971 1 gene36381 SEQ ID NO: 1658 CAG00570 MH0454 GL0090493 SEQ ID NO: 1658 CAG00570 158337416-stool1 revised C1197272 1 gene97970 SEQ ID NO: 1660 CAG00570 MH0366 GL0133228 SEQ ID NO: 1661 CAG00570 MH0366 GL0003291 SEQ ID NO: 1662 CAG00570 MH0366 GL0069655 SEQ ID NO: 1663 CAG00570 MH0366 GL0023679 SEQ ID NO: 1664 CAG00570 MH0366 GL0135591 SEQ ID NO: 1665 CAG00570 MH0366 GL0050575 SEQ ID NO: 1666 CAG00570 MH0366 GL0009276 SEQ ID NO: 1667 CAG00570 158337416- stool1 revised scaffold26304 1 gene216014 SEQ ID NO: 1668 CAG00570 MH0366 GL0140044 SEQ ID NO: 1669 CAG00570 158337416-stool1 revised C1218172 1 gene176424 SEQ ID NO: 1670 CAG00570 158337416-stool1 revised C1230400 1 gene160962SEQ ID NO: 1671 CAG00570 160704339-stool1 revised C1340293 1 gene152978 SEQ ID NO: 1672 CAG00570 MH0454 GL0213816 SEQ ID NO: Petição 870260080213, de 10 / 08 / 2026, pág. 171 / 398 161 / 296 1673 CAG00570 MH0366 GL0045814 SEQ ID NO: 1674 CAG005...

Claims

1. Use of a composition characterized by comprising at least one isolated or purified population of bacteria belonging to the Clostridiaceae family for the manufacture of a medicament to reduce or retard the growth of cancer in an individual.

2. Use according to claim 1, characterized in that each isolated or purified population of bacteria is present in the composition at a concentration of at least 103 CFU.

3. Use according to claim 1 or 2, characterized in that at least one isolated or purified population of bacteria is provided as bacterial spores.

4. Use, according to claim 1 or 2, characterized in that at least one isolated or purified population of bacteria belonging to the Clostridiaceae family comprises one or more species belonging to the genera Alkaliphilus, Bediuni, Butyricicoccus, Caloramator, Clostridium, Hungatella, Lactonifactor, Lutispora and / or Oxobacter.

5. Use, in accordance with a claim 1 or 2, characterized by pelo fato de que a pelo menos uma populación isolateda ou purificada de bacteria pertences à família Clostridiaceae comprehensi uma ou mais espeziale selecciona do grupo constituto por Alkaliphilus metalliredigens, Beduini massiliensis, Butyricicoccus pullicaecorum, Caloramator coolhaasii, Caloramator proteoclasticus, Caloramator quimbayensis, Clostridium amylolyticum, Clostridium bowmanii, Clostridium butyricum, Clostridium cadaveris, Clostridium chauvoei, Clostridium colicanis, Clostridium gasigenes, Clostridium oceanicum, Clostridium oryzae, Clostridium paraputrificum, Clostridium pascui, Clostridium perfringens, Clostridium quinii, Clostridium saccharobutylicum, Clostridium Petição 870260080213, of 10 / 08 / 2026, p. 308 / 398 2 / 4 sporogenes, Clostridium ventriculi, Hungatella effluvii, Hungatella hathewayii, Lactonifactor longoviformis, Lutispora thermophila and Oxobacter pfennigii.

6. Use, according to claim 1 or 2, characterized in that at least one isolated or purified population of bacteria belonging to the Clostridiaceae family comprises one or more of the species, subspecies or bacterial strains selected from the group consisting of the species in Table 1 with an enrichment index (ei) greater than 0.

5.

7. Use, according to claim 1 or 2, characterized in that at least one isolated or purified population of bacteria belonging to the Clostridiaceae family is selected from the species in Table 2 designated with a responder (R) response status.

8. Use, according to claim 1 or 2, characterized in that at least one isolated or purified population of bacteria belonging to the family Clostridiaceae comprises a species, subspecies or strain comprising nucleotide sequences with at least 80 percent identity to the sequences of the coabundant gene group (CAG) selected from the group consisting of SEQ ID NO: 877-926, SEQ ID NO: 927-976, SEQ ID NO: 977-1026, SEQ ID NO: 1027-1076, SEQ ID NO: 1077-1126, SEQ ID NO: 1127-1176, SEQ ID NO: 1177-1226, SEQ ID NO: 1227-1276, SEQ ID NO: 1277-1326, SEQ ID NO: 1327-1376, SEQ ID NO: 1377-1426, SEQ ID NO: 1427-1476, SEQ ID NO: 1477-1526, SEQ ID NO: 1527-1576, SEQ ID NO: 1577-1626, SEQ ID NO: 1627-1676, SEQ ID NO: 1677-1726, SEQ ID NO: 1727-1776, SEQ ID NO: 1777-1826, SEQ ID NO: 1827-1876, SEQ ID NO: 1877-1926, SEQ ID NO: 19271976, SEQ ID NO: 1977-2026, SEQ ID NO: 2027-2076, SEQ ID NO: 2077-2126, SEQ ID NO: 2127-2176, SEQ ID NO: 2177-2226, SEQ ID NO: 2227-2276,SEQ ID NO: 2277-2326, SEQ ID NO: 2327-2376, SEQ ID NO: 2377-2426, SEQ ID NO: 2427-2476, SEQ ID NO: 2477-2526, Petition 870260080213, dated 10 / 08 / 2026, pp. 309 / 398 3 / 4 SEQ ID NO: 2527-2576, SEQ ID NO: 2577-2626 and SEQ ID NO: 26272676.

9. Use, according to any one of claims 1 to 8, characterized in that the composition is formulated for oral administration.

10. Pharmaceutical formulation characterized by comprising an effective amount of the composition, as defined in any one of claims 1 to 9.

11. Use, according to any one of claims 1 to 9, characterized in that the cancer is a skin cancer selected from basal cell skin cancer, squamous cell skin cancer, melanoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma or angiosarcoma.

12. A method for predicting a response to an immune checkpoint inhibitor, characterized by comprising detecting a microbial profile in a sample obtained from a cancer patient, wherein, if the microbial profile comprises one or more populations of bacteria from the Clostridiaceae family, the response to the immune checkpoint inhibitor is favorable, and wherein the immune checkpoint inhibitor is an anti-PD-1 antibody, an anti-PD-L1 antibody, or an anti-CTLA-4 antibody.

13. Method for predicting a response to an immune checkpoint inhibitor characterized by comprising detecting a microbial profile in a sample obtained from a cancer patient, wherein, if the microbial profile comprises: (a) one or more bacteria belonging to the Clostridiaceae family, selected from the group consisting of the species in Table 1 with an enrichment index (ei) greater than 0.5; or (b) one or more of the bacterial species in Table 2 belonging to the Clostridiaceae family and designated with a responder (R) response state, then the patient is predicted to have a favorable response to the immune checkpoint inhibitor.

14. Method, according to claim 12 or 13, characterized in that the cancer is a skin cancer selected from basal cell skin cancer, squamous cell skin cancer, melanoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma or angiosarcoma.

15. Method, according to claim 12 or 13, characterized in that the microbial profile is a microbial profile of the intestine.

16. Method according to claim 12 or 13, characterized in that the immune checkpoint inhibitor is an anti-PD1 monoclonal antibody or an anti-CTLA4 monoclonal antibody.

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