Fungicidal oxadiazoles

Abstract

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R<com:Sup>1< / com:Sup>, L and J are as de- fined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the in- vention.

Description

TITLE FUNGICIDAL OXADIAZOLES FIELD OF THE INVENTION This invention relates to certain oxadiazoles, their N-oxides, salts and compositions, and methods of their use as fungicides. BACKGROUND OF THE INVENTION The control of plant diseases caused by fungal plant pathogens is extremely important in achieving high crop efficiency. Plant disease damage to ornamental, vegetable, field, cereal, and fruit crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. Many products are commercially available for these purposes, but the need continues for new compounds which are more effective, less costly, less toxic, environmentally safer or have different sites of action. PCT Patent Publications WO 2017 / 118689 and WO 2017 / 085100 disclose oxadiazole derivatives and their use as fungicides. SUMMARY OF THE INVENTION This invention is directed to compounds of Formula 1 (including all stereoisomers), N-oxides, hydrates (and solvates thereof), and salts thereof, agricultural compositions containing them and their use as fungicides: [Image disponible dans le document PDF, Image available in the PDF document] wherein R<com:Sup>1< / com:Sup> is a phenyl ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 3- to 7-membered nonaromatic ring or an 8- to 11-membered bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and optionally up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring or ring system optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; L is O, NR<com:Sup>3< / com:Sup>, NR<com:Sup>3< / com:Sup>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>NR<com:Sup>3< / com:Sup>, NR<com:Sup>3< / com:Sup>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>NR<com:Sup>3< / com:Sup>, (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, wherein the atom to the left is connected to R<com:Sup>1< / com:Sup>, and the atom to the right is connected to J, each carbon atom is optionally substituted with up to 2 substituents independently selected from halogen, cyano, hydroxy, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; J is a phenyl ring or a naphthalenyl ring system, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>; or a 3- to 7-membered carbocyclic ring, wherein up to 3 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>; or J is a 5- to 6-membered heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>; each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, hydroxy, nitro, thioyl, -SF<com:Sub>5< / com:Sub>, -CH(=O), <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NR3aR3b<annotation encoding="application / x-tex">-NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)NR3aR3b<annotation encoding="application / x-tex">-C(=S)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N=CR8NR9aR9b<annotation encoding="application / x-tex">-N=CR^8NR^{9a}R^{9b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkenyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminosulfinyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> dialkylaminosulfinyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkylsulfonyloxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkylsulfonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkyloxycarbonylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylaminocarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylaminocarbonylamino or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> dialkoxyphosphinyl, each optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>; each <com:Math><semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfinylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl; each <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> hydroxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> cyanoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkenyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>6< / com:Sub>-C<com:Sub>14< / com:Sub> cycloalkylcycloalkyl, C<com:Sub>5< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkoxyalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> alkoxyalkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfinylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminoalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkylaminoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> dialkylaminoalkyl or C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylaminoalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, nitro, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> halotrialkylsilyl; or a pair of R<com:Sup>3a< / com:Sup> and R<com:Sup>3b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form a 4- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 3 substituents independently selected from halogen and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl; each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, cyano, hydroxy, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; or a pair of R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> substituents attached to the same carbon atom are taken together to form a C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> cycloalkyl ring optionally substituted with up to 2 substituents independently selected from halogen, methyl, methoxy and methylthio; each R<com:Sup>5< / com:Sup> is independently hydroxy, cyano, nitro, halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy; each R<com:Sup>6< / com:Sup> is independently H, cyano, halogen, methyl, methoxy, methylthio or methoxycarbonyl; each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently hydroxy or <com:Math><semantics>NR11aR11b<annotation encoding="application / x-tex">NR^{11a}R^{11b}< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyloxy or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> dialkylaminocarbonyloxy, each optionally substituted with up to 1 substituent selected from halogen, cyano, hydroxy and <com:Math><semantics>−C(=O)OH;<annotation encoding="application / x-tex">-C(=O)OH;< / annotation>< / semantics>< / com:Math> each R<com:Sup>8< / com:Sup> is independently H, methyl, methoxy or methylthio; each <com:Math><semantics>R9a<annotation encoding="application / x-tex">R^{9a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R9b<annotation encoding="application / x-tex">R^{9b}< / annotation>< / semantics>< / com:Math> is independently H or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl; or a pair of <com:Math><semantics>R9a<annotation encoding="application / x-tex">R^{9a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R9b<annotation encoding="application / x-tex">R^{9b}< / annotation>< / semantics>< / com:Math> substituents are taken together with the nitrogen atom to which they are attached to form a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl; each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, amino, cyano, hydroxy, nitro, thioyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> halocycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> dialkylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkylthioalkylcarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsily, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> halotrialkylsilyl, <com:Math><semantics>−C(R13)=NOR14 or −C(R15)=NR16<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14} \text{ or } -C(R^{15})=NR^{16}< / annotation>< / semantics>< / com:Math>; each U is independently a direct bond, C(=O)O, C(=O)NR<com:Sup>17< / com:Sup> or C(=S)NR<com:Sup>18< / com:Sup>, wherein the atom to the left is connected to R<com:Sup>1< / com:Sup>, and the atom to the right is connected to V; each V is independently a direct bond; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylene, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenylene, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynylene, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkylene or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkenylene, each optionally substituted with up to 3 substituents independently selected from halogen, cyano, nitro, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxy and C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkoxy; each Q is independently phenyl or phenoxy, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or each Q is independently a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from <com:Math><semantics>R12<annotation encoding="application / x-tex">R^{12}< / annotation>< / semantics>< / com:Math>; or each Q is independently a 3- to 7-membered nonaromatic heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; each <com:Math><semantics>R11a<annotation encoding="application / x-tex">R^{11a}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl; each R<com:Sup>11b< / com:Sup> is independently H, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl; or a pair of R<com:Sup>11a< / com:Sup> and R<com:Sup>11b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl; each R<com:Sup>12< / com:Sup> is independently halogen, cyano, hydroxy, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl; each R<com:Sup>13< / com:Sup> and R<com:Sup>15< / com:Sup> is independently H, cyano, halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> cycloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkoxy; or a phenyl ring optionally substituted with up to 2 substituents independently selected from halogen and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl; each R<com:Sup>14< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> halocycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonyl; or each R<com:Sup>14< / com:Sup> is a phenyl ring optionally substituted with up to 2 substituents independently selected from halogen and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl; or a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 substituents independently selected from halogen and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl; each <com:Math><semantics>R16<annotation encoding="application / x-tex">R^{16}< / annotation>< / semantics>< / com:Math> is independently H, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl; each <com:Math><semantics>R17<annotation encoding="application / x-tex">R^{17}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R18<annotation encoding="application / x-tex">R^{18}< / annotation>< / semantics>< / com:Math> is independently H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxycarbonyl; and n is 1, 2 or 3; provided that: (a) when L is <com:Math><semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>< / com:Math>, and J is unsubstituted phenyl, then <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math> is other than 3-(methoxyimino)-1-pyrrolidinyl, 5-(methylsulfinyl)-1H-1,2,4-triazol-3-yl, 5-(ethylthio)-1H-1,2,4-triazol-3-yl, 5-(propylthio)-1H-1,2,4-triazol-3-yl, 2,3- dihydro-5-methyl-3-oxo-1H-pyrazol-1-yl, 1-piperidinyl, 4-(methoxyimino)-1- piperidinyl, 4-morpholinyl, 2,6-dimethyl-4-morpholinyl, 4-(methylsulfonyl)-1- piperazinyl, 4-thiomorpholinyl, 6-methoxy-3-pyridinyl or 1,2,3,6-tetrahydro-1,3- dimethyl-2,6-dioxo-7H-purin-7-yl; (b) when R<com:Sup>1< / com:Sup> is a 5-membered heterocyclic ring containing 2 to 4 nitrogen atoms, each ring optionally substituted with up to 3 substituents independently selected from cyano, Br, Cl, I, CH<com:Sub>3< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxycarbonyl and 4-chlorophenyl, and L is CH<com:Sub>2< / com:Sub>, then J is other than pyridine; (c) when R<com:Sup>1< / com:Sup> is 1H-pyrazol-1-yl substituted with 1-2 substituents independently selected from CH<com:Sub>3< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>C(=O), and J is unsubstituted phenyl, then L is other than CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CHF or CH(CH<com:Sub>3< / com:Sub>); (d) when L is <com:Math><semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>< / com:Math>, and J is unsubstituted phenyl, then <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math> is other than <com:Math><semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>< / com:Math>-indazole, 2H-indazole, 1H-indole, 1H-pyrrole, 2-piperidinone or 2-pyrrolidinone, each optionally substituted with up to 3 substituents independently selected from -CH(=O), CH<com:Sub>3< / com:Sub>C(=O), cyano, Cl, F, CH<com:Sub>3< / com:Sub>, (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHCH<com:Sub>2< / com:Sub>, CF<com:Sub>3< / com:Sub>, CH<com:Sub>3< / com:Sub>O and <com:Math><semantics>CH3OC(=O);<annotation encoding="application / x-tex">CH_3OC(=O);< / annotation>< / semantics>< / com:Math> (e) the compound of Formula 1 is not a compound of F-1 F-1 wherein [Image disponible dans le document PDF, Image available in the PDF document] ___· 7 wherein for Z-1 through Z-9, the substituents <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> may be the same or different; and wherein for Z-1: m is 0; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 3-postion and is 3-(CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O))-2-pyridinyl, Cl, CF<com:Sub>3< / com:Sub> or -CH(=O); and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> are each H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 4-postion and is halogen, cyano, CF<com:Sub>3< / com:Sub>, -CH(=O), OHC(=O), C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, <com:Math><semantics>NH2C(=O)<annotation encoding="application / x-tex">NH_2C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3NHC(=O)<annotation encoding="application / x-tex">CH_3NHC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2NHC(=O)<annotation encoding="application / x-tex">CH_3CH_2NHC(=O)< / annotation>< / semantics>< / com:Math>, (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>NCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O), cyclopropyl-NHC(=O), cyclopropyl-CH<com:Sub>2< / com:Sub>NHC(=O), <com:Math><semantics>(CH3)2NC(=O)<annotation encoding="application / x-tex">(CH_3)_2NC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3CH2)2NC(=O)<annotation encoding="application / x-tex">(CH_3CH_2)_2NC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3ONHC(=O)<annotation encoding="application / x-tex">CH_3ONHC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3OCH2CH2NHC(=O)<annotation encoding="application / x-tex">CH_3OCH_2CH_2NHC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH=CCH2NHC(=O)<annotation encoding="application / x-tex">CH=CCH_2NHC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3ON(CH3)C(=O)<annotation encoding="application / x-tex">CH_3ON(CH_3)C(=O)< / annotation>< / semantics>< / com:Math>, CH<com:Sub>3< / com:Sub>ON=CH, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>ON=CH, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>ON=CH, (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHON=CH, CH≡CCH<com:Sub>2< / com:Sub>ON=CH, phenyl-CH<com:Sub>2< / com:Sub>ON=CH or 4-morpholinylcarbonyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4-postion and is <com:Math><semantics>CH3CH2C(=O)<annotation encoding="application / x-tex">CH_3CH_2C(=O)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is F; or m is 1; R<com:Sup>1a< / com:Sup> is at the 4-postion and is Br, Cl or I; R<com:Sup>2a< / com:Sup> is F or Cl; and R<com:Sup>2b< / com:Sup> is H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 3- and 4-postions and is cyano, CF<com:Sub>2< / com:Sub>H, CF<com:Sub>3< / com:Sub>, CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, cyclopropyl, phenyl or 4-chlorophenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 2; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 3- and 5-postions and is cyano, <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CF2H<annotation encoding="application / x-tex">CF_2H< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math>, cyclopropyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, 4-fluorophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl or 4-methoxyphenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 3- and 5-postions and is CH<com:Sub>3< / com:Sub>; R<com:Sup>2a< / com:Sup> is F or Cl; and R<com:Sup>2b< / com:Sup> is H; or m is 2; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 3- and 5-postions and is <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is F; or m is 2; R<com:Sup>1a< / com:Sup> is at the 4- and 5-postions and is CF<com:Sub>2< / com:Sub>H, cyclopropyl, CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub> orC<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 3; R<com:Sup>1a< / com:Sup> is at the 3-, 4- and 5-postions and is cyano, Cl, CH<com:Sub>3< / com:Sub>, CF<com:Sub>3< / com:Sub>, 4-chlorophenyl, 2,4-dichlorophenyl or 2,2-difluoro-1,3-benzodioxol-4-yl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 3; R<com:Sup>1a< / com:Sup> is at the 3-, 4- and 5-postions and is Cl or CH<com:Sub>3< / com:Sub>; R<com:Sup>2a< / com:Sup> is F; and R<com:Sup>2b< / com:Sup> is H; wherein for Z-2: m is 0; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H, Cl or F; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 2-postion and is Br, <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3)2CH<annotation encoding="application / x-tex">(CH_3)_2CH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, phenyl or 4-fluorophenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 2-postion and is CH<com:Sub>3< / com:Sub>; R<com:Sup>2a< / com:Sup> is F; and R<com:Sup>2b< / com:Sup> is H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 4-postion and is cyano, Br, I, CH<com:Sub>3< / com:Sub>, CF<com:Sub>3< / com:Sub>, -CH(=O), CH<com:Sub>3< / com:Sub>OC(=O), CH<com:Sub>3< / com:Sub>C(=O)NHCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, phenyl or 4-chlorophenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 4-postion and is Br or CH<com:Sub>3< / com:Sub>; R<com:Sup>2a< / com:Sup> is Cl, F, CF<com:Sub>3< / com:Sub> or CH<com:Sub>3< / com:Sub>O; and R<com:Sup>2b< / com:Sup> is H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5-postion and is <com:Math><semantics>CH3OC(=O)<annotation encoding="application / x-tex">CH_3OC(=O)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> are each H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 5-postion and is Br; R<com:Sup>2a< / com:Sup> is CH<com:Sub>3< / com:Sub>O; and R<com:Sup>2b< / com:Sup> is H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 2- and 4-postions and is Br, Cl, CH<com:Sub>3< / com:Sub>, CHF<com:Sub>2< / com:Sub>S or 4-chlorophenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 2- and 4-postions and is CH<com:Sub>3< / com:Sub>; R<com:Sup>2a< / com:Sup> is Cl or F; and R<com:Sup>2b< / com:Sup> is H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 4- and 5-postions and is cyano, Cl, CH<com:Sub>3< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl or phenyl; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 2; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4- and 5-postions and is Cl, cyano or <com:Math><semantics>CH3OC(=O)<annotation encoding="application / x-tex">CH_3OC(=O)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is F or Cl; and R<com:Sup>2b< / com:Sup> is H; or m is 3; R<com:Sup>1a< / com:Sup> is at the 2-, 4- and 5-postions and is Br, Cl, CF<com:Sub>3< / com:Sub>, CF<com:Sub>3< / com:Sub>S, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O) or 4-chlorophenyl; and R<com:Sup>2a< / com:Sup> iand R<com:Sup>2b< / com:Sup> are each H; or wherein for Z-3: m is 0; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H, Cl, F, <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH3O<annotation encoding="application / x-tex">CH_3O< / annotation>< / semantics>< / com:Math>; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 3-postion and is cyano, CF<com:Sub>3< / com:Sub>, CH<com:Sub>3< / com:Sub>S, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>S, CH<com:Sub>3< / com:Sub>S(=O), CH<com:Sub>3< / com:Sub>S(=O)<com:Sub>2< / com:Sub>, phenyl-CH<com:Sub>2< / com:Sub>S, CH<com:Sub>3< / com:Sub>OC(=O) or (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>N; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 3-postion and is cyano; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is F; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 3-postion and is <com:Math><semantics>CH3OC(=O)<annotation encoding="application / x-tex">CH_3OC(=O)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is F or Cl; and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> is H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5-postion and is cyano, <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3S<annotation encoding="application / x-tex">CH_3S< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2S<annotation encoding="application / x-tex">CH_3CH_2S< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3S(=O)2<annotation encoding="application / x-tex">CH_3S(=O)_2< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH3OC(=O)<annotation encoding="application / x-tex">CH_3OC(=O)< / annotation>< / semantics>< / com:Math>; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2b<annotation encoding="application / x-tex">R^{2b}< / annotation>< / semantics>< / com:Math> are each H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 5-postion and is cyano; R<com:Sup>2a< / com:Sup> is H; and R<com:Sup>2b< / com:Sup> is F; or m is 2; R<com:Sup>1a< / com:Sup> is at the 3- and 5-postions and is Br, CF<com:Sub>2< / com:Sub>H, CF<com:Sub>3< / com:Sub>, CH<com:Sub>3< / com:Sub>O or NH<com:Sub>2< / com:Sub>; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or wherein for Z-4: m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4-postion and is cyano, OHC(=O), <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkyl, cyclopropyl, cyclopentyl, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylaminocarbonyl, CH<com:Sub>3< / com:Sub>ONHC(=O), 4-chlorophenyl-NHC(=O), 4-methoxyphenyl-NHC(=O), 4-pyrdinyl-NHC(<com:Math><semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics>< / com:Math>O), (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>NC(<com:Math><semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics>< / com:Math>O), CH<com:Sub>3< / com:Sub>ON(CH<com:Sub>3< / com:Sub>)C(<com:Math><semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics>< / com:Math>O), 3-thienyl, phenyl-C(=O)NHC(Me)<com:Sub>2< / com:Sub>, phenyl, 4-fluorophenyl, 4-methylphenyl, 4-methoxyphenyl, 2-pyridinyl, 3-pyridinyl, 1-ethyl-3-methyl-1H-pyrazol-4-yl, 1-ethyl-5-methyl-1H-pyrazol-4-yl, 1-methyl-1H-imidazol-5-yl or (CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>Si; and R<com:Sup>2a< / com:Sup> and R<com:Sup>2b< / com:Sup> are each H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5-postion and is phenyl, <com:Math><semantics>CH3OC(=O)<annotation encoding="application / x-tex">CH_3OC(=O)< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH3NHC(=O)<annotation encoding="application / x-tex">CH_3NHC(=O)< / annotation>< / semantics>< / com:Math>; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> and R<com:Sup>2b< / com:Sup> are each H; or wherein for Z-5: k is 1 or 2; each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently Cl, Br or CH<com:Sub>3< / com:Sub>; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H, Cl or F; 9 wherein for Z-6: k is 1 or 2; each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently Br, Cl, <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>; wherein for Z-7: m is 0; or m is 1; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5-postion and is <com:Math><semantics>CH3CH2OC(=O)<annotation encoding="application / x-tex">CH_3CH_2OC(=O)< / annotation>< / semantics>< / com:Math>; or m is 2; and R<com:Sup>1a< / com:Sup> is at the 4- and 5-positions and is Cl, CH<com:Sub>3< / com:Sub>, CF<com:Sub>3< / com:Sub> or 4-fluorophenoxy; or m is 2; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4- and 6-positions and is Cl or <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math>; or m is 2; and R<com:Sup>1a< / com:Sup> is at the 5- and 6-positions and is Cl or 4-methoxyphenoxy; or m is 2; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5- and 7-positions and is Cl or <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math>; or 10 m is 2; and R<com:Sup>1a< / com:Sup> is at the 6- and 7-positions and is Cl or 4-fluorophenoxy; or m is 3; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4-, 5- and 6-positions and is Br or <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>; wherein for Z-8: m is 0; or m is 1; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5-postion and is <com:Math><semantics>CH3CH2OC(=O)<annotation encoding="application / x-tex">CH_3CH_2OC(=O)< / annotation>< / semantics>< / com:Math>; or 15 m is 2; and R<com:Sup>1a< / com:Sup> is at the 4- and 5-positions and is Cl, CH<com:Sub>3< / com:Sub> or 4-fluorophenoxy; or m is 2; and R<com:Sup>1a< / com:Sup> is at the 4- and 6-positions and is CF<com:Sub>3< / com:Sub> or Cl; or m is 2; and R<com:Sup>1a< / com:Sup> is at the 5- and 6-positions and is Cl or 4-methoxyphenoxy; or m is 3; and <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4-, 5- and 6-positions and is Br or <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>; wherein for Z-9: m is 0; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is Cl or F; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 2-position and is <com:Math><semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2<annotation encoding="application / x-tex">CH_3CH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>N≡CCH2<annotation encoding="application / x-tex">N \equiv CCH_2< / annotation>< / semantics>< / com:Math> or 4-pyridinyl; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; or m is 1; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 4-position and is Cl; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; or m is 1; R<com:Sup>1a< / com:Sup> is at the 7-position and is Cl; and R<com:Sup>2a< / com:Sup> is H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 2- and 5-positions and is CH<com:Sub>3< / com:Sub> or CF<com:Sub>3< / com:Sub>; and R<com:Sup>2a< / com:Sup> is H; or m is 2; R<com:Sup>1a< / com:Sup> is at the 2- and 5-positions and is CH<com:Sub>3< / com:Sub> or F; and R<com:Sup>2a< / com:Sup> is F; or m is 2; R<com:Sup>1a< / com:Sup> is at the 2- and 6-positions and is CH<com:Sub>3< / com:Sub> or CF<com:Sub>3< / com:Sub>; and R<com:Sup>2a< / com:Sup> is H; or m is 2; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 2- and 6-positions and is <com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math> or F; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is F; or m is 2; <com:Math><semantics>R1a<annotation encoding="application / x-tex">R^{1a}< / annotation>< / semantics>< / com:Math> is at the 5- and 6-positions and is Cl or F; and <com:Math><semantics>R2a<annotation encoding="application / x-tex">R^{2a}< / annotation>< / semantics>< / com:Math> is H; and (f) the compound of Formula 1 is not <com:Math><semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>< / com:Math>-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]-4-morpholineacetonitrile; 3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3H-1,2,3- triazolo[4,5-b]pyridine; 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-2H-1,2,3- triazolo[4,5-b]pyridine; 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1H-1,2,3- triazolo[4,5-b]pyridine; 4-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-4H-1,2,3- 10 triazolo[4,5-b]pyridine; 5-(2,6-difluorophenyl)-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3- yl]phenyl]methyl]-2H-1,2,3-triazole-4-carbonitrile; 3-[4-(4H-1,2,4-triazol-4-ylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; <com:Math><semantics>3−[4−[[3−[(phenylmethyl)thio]−4H−1,2,4−triazol−4−yl]methyl]phenyl]−5−<annotation encoding="application / x-tex">3-[4-[[3-[(phenylmethyl)thio]-4H-1,2,4-triazol-4-yl]methyl]phenyl]-5-< / annotation>< / semantics>< / com:Math> (trifluoromethyl)-1,2,4-oxadiazole; 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1H-pyrrolo[3,2- bpyridine-2-carbonitrile; 7-[[2-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-7H- pyrrolo[2,3-b]pyridine; 3-[3-fluoro-4-[(5-methyl-1H-imidazol-2-yl)methyl]phenyl]-5-(trifluoromethyl)- 1,2,4-oxadiazole; 5,6-dihydro-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]- cyclopenta[c]pyrrol-4(2H)-one 2-methoxy-5-[1-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]- pyridine; 3-[4-[(4,5-dihydro-5,5-dimethyl-2-oxazolyl)methyl]phenyl]-5-(trifluoromethyl)- 1,2,4-oxadiazole; N-(2,2,2-trifluoro-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3- yl)phenyl)ethyl)cyclopropanamine; 4-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1H-pyrrolo[3,2- b]pyridine-2-carbonitrile; 3-[4-(2H-1,2,3-triazol-2-ylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; or 3-[4-(1H-1,2,3-triazol-1-ylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole. More particularly, this invention pertains to a compound of Formula 1 (including all geometric and stereoisomers), tautomers, an N-oxide, or a salt thereof. This invention also relates to a fungicidal composition comprising (a) a compound of Formula 1; and (b) at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. This invention also relates to a fungicidal composition comprising (a) a compound of Formula 1; and (b) at least one other fungicide (e.g., at least one other fungicide having a different site of action). This invention further relates to a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of the invention (e.g., as a composition described herein). DETAILS OF THE INVENTION As used herein, the terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," "characterized by" or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, method, article, or apparatus. The transitional phrase "consisting of" excludes any element, step, or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole. The transitional phrase "consisting essentially of" is used to define a composition, method or apparatus that includes materials, steps, features, components, or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term "consisting essentially of" occupies a middle ground between "comprising" and "consisting of". Where applicants have defined an invention or a portion thereof with an open-ended term such as "comprising," it should be readily understood that (unless otherwise stated) the description should be interpreted to also describe such an invention using the terms "consisting essentially of" or "consisting of." Further, unless expressly stated to the contrary, "or" refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present). Also, the indefinite articles "a" and "an" preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore "a" or "an" should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular. As referred to in the present disclosure and claims, "plant" includes members of Kingdom Plantae, particularly seed plants (Spermatopsida), at all life stages, including young plants (e.g., germinating seeds developing into seedlings) and mature, reproductive stages (e.g., plants producing flowers and seeds). Portions of plants include geotropic members typically growing beneath the surface of the growing medium (e.g., soil), such as 12 roots, tubers, bulbs and corms, and also members growing above the growing medium, such as foliage (including stems and leaves), flowers, fruits and seeds. As referred to herein, the term "seedling", used either alone or in a combination of words means a young plant developing from the embryo of a seed. As referred to herein, the term "broadleaf" used either alone or in words such as "broadleaf crop" means dicot or dicotyledon, a term used to describe a group of angiosperms characterized by embryos having two cotyledons. As referred to in this disclosure, the terms "fungal pathogen" and "fungal plant pathogen" include pathogens in the Ascomycota, Basidiomycota and Zygomycota phyla, and the fungal-like Oomycota class that are the causal agents of a broad spectrum of plant diseases of economic importance, affecting ornamental, turf, vegetable, field, cereal and fruit crops. In the context of this disclosure, "protecting a plant from disease" or "control of a plant disease" includes preventative action (interruption of the fungal cycle of infection, colonization, symptom development and spore production) and / or curative action (inhibition of colonization of plant host tissues). As used herein, the term "mode of action" (MOA) is as define by the Fungicide Resistance Action Committee (FRAC), and is used to distinguish fungicides according to their biochemical mode of action in the biosynthetic pathways of plant pathogens. FRAC-defined modes of actions include (A) nucleic acid synthesis, (B) mitosis and cell division, (C) respiration, (D) amino acid and protein synthesis, (E) signal transduction, (F) lipid synthesis and membrane integrity, (G) sterol biosynthesis in membranes, (H) cell wall biosynthesis, (I) melanin synthesis in cell wall, (P) host plant defense induction, (U) unknown mode of action, (NC) not classified and (M) multi-site contact activity. Each mode of action (i.e. letters A through M) contain one or more subgroups (e.g., A includes subgroups A1, A2, A3 and A4) based either on individual validated target sites of action, or in cases where the precise target site is unknown, based on cross resistance profiles within a group or in relation to other groups. Each of these subgroups (e.g., A1, A2, A3 and A4) is asigned a FRAC code (a number and / or letter). For example, the FRAC code for subgroup A1 is 4. Additional information on target sites and FRAC codes can be obtained from publicly available databases maintained, for example, by FRAC. As used herein, the term "cross resistance" refers to the phenomenon that occurs when a pathogen develops resistance to one fungicide and simultaneously becomes resistant to one or more other fungicides. These other fungicides are typically, but not always, in the same chemical class or have the same target site of action, or can be detoxified by the same mechanism. Generally when a molecular fragment (i.e. radical) is denoted by a series of atom symbols (e.g., C, H, N, O and S) the implicit point or points of attachment will be easily recognized by those skilled in the art. In some instances herein, particularly when alternative 13 points of attachment are possible, the point or points of attachment may be explicitly indicated by a hyphen ("-"). For example, "-SCN" indicates that the point of attachment is the sulfur atom (i.e. thiocyanato, not isothiocyanato). As used herein, the term "alkylating agent" refers to a chemical compound in which a carbon-containing radical is bound through a carbon atom to a leaving group such as halide or sulfonate, which is displaceable by bonding of a nucleophile to said carbon atom. Unless otherwise indicated, the term "alkylating" does not limit the carbon-containing radical to alkyl; the carbon-containing radicals in alkylating agents include the variety of carbon-bound substituent radicals specified, for example, for R<com:Sup>2< / com:Sup>. In the above recitations, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl" includes straight-chain and branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, and the different butyl, pentyl and hexyl isomers. "Alkenyl" includes straight-chain and branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. "Alkenyl" also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. "Alkynyl" includes straight-chain and branched alkynes such as ethynyl, 1-propynyl, 2-propynyl, and the different butynyl, pentynyl and hexynyl isomers. "Alkynyl" can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. "Alkylene" denotes a straight-chain or branched alkanediyl. Examples of "alkylene" include CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH(CH<com:Sub>3< / com:Sub>), CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH(CH<com:Sub>3< / com:Sub>), and the different butylene isomers. "Alkenylene" denotes a straight-chain or branched alkenediyl containing one olefinic bond. Examples of "alkenylene" include CH=CH, CH<com:Sub>2< / com:Sub>CH=CH, CH=C(CH<com:Sub>3< / com:Sub>) and the different butenylene isomers. The term "cycloalkylene" denotes a cycloalkanediyl ring. Examples of "cycloalkylene" include cyclopropylene, cyclobutylene, cyclopentylene and cyclohexylene. The term "cycloalkenylene" denotes a cycloalkenediyl ring containing one olefinic bond. Examples of "cycloalkenylene" include cylopropenediyl and cyclpentenediyl. "Alkoxy" includes, for example, methoxy, ethoxy, n-propyloxy, i-propyloxy, and the different butoxy, pentoxy and hexyloxy isomers. "Alkenyloxy" includes straight-chain and branched alkenyl attached to and linked through an oxygen atom. Examples of "alkenyloxy" include H<com:Sub>2< / com:Sub>C=CHCH<com:Sub>2< / com:Sub>O and CH<com:Sub>3< / com:Sub>CH=CHCH<com:Sub>2< / com:Sub>O. "Alkynyloxy" includes straight-chain and branched alkynyloxy moieties. Examples of "alkynyloxy" include HC≡CCH<com:Sub>2< / com:Sub>O and CH<com:Sub>3< / com:Sub>C≡CCH<com:Sub>2< / com:Sub>O. The term "alkylthio" includes straight-chain and branched alkylthio moieties such as methylthio, ethylthio, and the different propylthio and butylthio isomers. "Alkylsulfinyl" includes both enantiomers of an alkylsulfinyl group. Examples of "alkylsulfinyl" include <com:Math><semantics>CH3S(=O)<annotation encoding="application / x-tex">CH_3S(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2S(=O)<annotation encoding="application / x-tex">CH_3CH_2S(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2CH2S(=O)<annotation encoding="application / x-tex">CH_3CH_2CH_2S(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3)2CHS(=O)<annotation encoding="application / x-tex">(CH_3)_2CHS(=O)< / annotation>< / semantics>< / com:Math>, and the different butylsulfinyl isomers. Examples of "alkylsulfonyl" include CH<com:Sub>3< / com:Sub>S(=O)<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>S(=O)<com:Sub>2< / com:Sub>, <com:Math><semantics>CH3CH2CH2S(=O)2<annotation encoding="application / x-tex">CH_3CH_2CH_2S(=O)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3)2CHS(=O)2<annotation encoding="application / x-tex">(CH_3)_2CHS(=O)_2< / annotation>< / semantics>< / com:Math>, and the different butylsulfonyl isomers. "Alkylthioalkyl" denotes alkylthio substitution on alkyl. Examples of "alkylthioalkyl" include CH<com:Sub>3< / com:Sub>SCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>SCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>SCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>SCH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>SCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>; "alkylsulfinylalkyl" and "alkylsulfonylalkyl" include the corresponding sulfoxides and sulfones, respectively. "Alkylamino" includes an NH radical substituted with a straight-chain or branched alkyl group. Examples of "alkylamino" include CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>NH, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>NH, and (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHCH<com:Sub>2< / com:Sub>NH. Examples of "dialkylamino" include (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>N, (CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>N and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>(CH<com:Sub>3< / com:Sub>)N. "Alkylaminoalkyl" denotes alkylamino substitution on alkyl. Examples of "alkylaminoalkyl" include CH<com:Sub>3< / com:Sub>NHCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>NHCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>NHCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>NHCH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>NHCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>. "Alkylcarbonyl" denotes a straight-chain or branched alkyl group bonded to a C(=O) moiety. Examples of "alkylcarbonyl" include <com:Math><semantics>CH3C(=O)<annotation encoding="application / x-tex">CH_3C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2CH2C(=O)<annotation encoding="application / x-tex">CH_3CH_2CH_2C(=O)< / annotation>< / semantics>< / com:Math> and (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHC(=O). Examples of "alkoxycarbonyl" include CH<com:Sub>3< / com:Sub>OC(=O), CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O), <com:Math><semantics>CH3CH2CH2OC(=O)<annotation encoding="application / x-tex">CH_3CH_2CH_2OC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3)2CHOC(=O)<annotation encoding="application / x-tex">(CH_3)_2CHOC(=O)< / annotation>< / semantics>< / com:Math>, and the different butoxy- and pentoxycarbonyl isomers. Examples of "alkylaminocarbonyl" include CH<com:Sub>3< / com:Sub>NHC(=O), CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>NHC(=O), CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>NHC(=O), (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHNHC(=O), and the different butylamino- and pentylaminocarbonyl isomers. Examples of "dialkylaminocarbonyl" include <com:Math><semantics>(CH3)2NC(=O)<annotation encoding="application / x-tex">(CH_3)_2NC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3CH2)2NC(=O)<annotation encoding="application / x-tex">(CH_3CH_2)_2NC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2(CH3)NC(=O)<annotation encoding="application / x-tex">CH_3CH_2(CH_3)NC(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(CH3)2CH(CH3)NC(=O)<annotation encoding="application / x-tex">(CH_3)_2CH(CH_3)NC(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>CH3CH2CH2(CH3)NC(=O)<annotation encoding="application / x-tex">CH_3CH_2CH_2(CH_3)NC(=O)< / annotation>< / semantics>< / com:Math>. The term "alkylcarbonylamino" denotes alkyl bonded to a <com:Math><semantics>C(=O)NH<annotation encoding="application / x-tex">C(=O)NH< / annotation>< / semantics>< / com:Math> moiety. Examples of "alkylcarbonylamino" include <com:Math><semantics>CH3CH2C(=O)NH<annotation encoding="application / x-tex">CH_3CH_2C(=O)NH< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>CH3CH2CH2C(=O)NH<annotation encoding="application / x-tex">CH_3CH_2CH_2C(=O)NH< / annotation>< / semantics>< / com:Math>. The term "alkoxycarbonylamino" denotes alkoxy bonded to a C(=O)NH moiety. Examples of "alkoxycarbonylamino" include CH<com:Sub>3< / com:Sub>OC(=O)NH and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O)NH. "Alkylsulfonylamino" denotes an NH radical substituted with alkylsulfonyl. Examples of "alkylsulfonylamino" include CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>S(=O)<com:Sub>2< / com:Sub>NH and (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHS(=O)<com:Sub>2< / com:Sub>NH. The term "alkylsulfonyloxy" denotes an alkylsulfonyl group bonded to an oxygen atom. Examples of "alkylsulfonyloxy" include <com:Math><semantics>CH3S(=O)2O<annotation encoding="application / x-tex">CH_3S(=O)_2O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2S(=O)2O<annotation encoding="application / x-tex">CH_3CH_2S(=O)_2O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CH3CH2CH2S(=O)2O<annotation encoding="application / x-tex">CH_3CH_2CH_2S(=O)_2O< / annotation>< / semantics>< / com:Math>, (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHS(=O)<com:Sub>2< / com:Sub>O, and the different butylsulfonyloxy, pentylsulfonyloxy and hexylsulfonyloxy isomers. "Alkoxyalkyl" denotes alkoxy substitution on alkyl. Examples of "alkoxyalkyl" include CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>. "Alkoxyalkoxy" denotes alkoxy substitution on another alkoxy moiety. "Alkoxyalkoxyalkyl" denotes alkoxyalkoxy substitution on alkyl. Examples of "alkoxyalkoxyalkyl" include CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub> CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>. The term "alkylcarbonyloxy" denotes a straight-chain or branched alkyl bonded to a <com:Math><semantics>C(=O)O<annotation encoding="application / x-tex">C(=O)O< / annotation>< / semantics>< / com:Math> moiety. Examples of "alkylcarbonyloxy" include CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>C(=O)O and (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHC(=O)O. Examples of "alkoxycarbonyloxy" include CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O)O and (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHOC(=O)O. The term "alkoxycarbonylalkyl" denotes alkoxycarbonyl substitution on alkyl. Examples of "alkoxycarbonylalkyl" include CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OC(=O)CH<com:Sub>2< / com:Sub>, <com:Math><semantics>(CH3)2CHOC(=O)CH2<annotation encoding="application / x-tex">(CH_3)_2CHOC(=O)CH_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>CH3OC(=O)CH2CH2<annotation encoding="application / x-tex">CH_3OC(=O)CH_2CH_2< / annotation>< / semantics>< / com:Math>. The term "alkylaminocarbonyloxy" denotes a straight-chain or branched alkylaminocarbonyl attached to and linked through an oxygen atom. Examples of "alkylaminocarbonyloxy" include (CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>CHCH<com:Sub>2< / com:Sub>NHC(=O)O and <com:Math><semantics>CH3CH2NHC(=O)O<annotation encoding="application / x-tex">CH_3CH_2NHC(=O)O< / annotation>< / semantics>< / com:Math>. "Cycloalkyl" includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term "cycloalkylalkyl" denotes cycloalkyl substitution on an alkyl moiety. Examples of "cycloalkylalkyl" include cyclopropylmethyl, cyclopentylethyl, and other cycloalkyl moieties bonded to a straight-chain or branched alkyl group. The term "alkylcycloalkyl" denotes alkyl substitution on a cycloalkyl moiety and includes, for example, ethylcyclopropyl, i-propylcyclobutyl, methylcyclopentyl and methylcyclohexyl. "Alkylcycloalkylalkyl" denotes an alkyl group substituted with alkylcycloalkyl. Examples of "alkylcycloalkylalkyl" include methylcyclohexylmethyl and ethylcycloproylmethyl. "Cycloalkenyl" includes groups such as cyclopentenyl and cyclohexenyl as well as groups with more than one double bond such as 1,3- or 1,4-cyclohexadienyl. The term "cycloalkylcycloalkyl" denotes cycloalkyl substitution on another cycloalkyl ring, wherein each cycloalkyl ring independently has from 3 to 7 carbon atom ring members. Examples of cycloalkylcycloalkyl include cyclopropylcyclopropyl (such as 1,1'-bicyclopropyl-1-yl, 1,1'- bicyclopropyl-2-yl), cyclohexylcyclopentyl (such as 4-cyclopentylcyclohexyl) and cyclohexylcyclohexyl (such as 1,1'-bicyclohexyl-1-yl), and the different cis- and trans- cycloalkylcycloalkyl isomers, (such as <com:Math><semantics>(1R,2S)−1,1<annotation encoding="application / x-tex">(1R,2S)-1,1< / annotation>< / semantics>< / com:Math>'-bicyclopropyl-2-yl and <com:Math><semantics>(1R,2R)−1,1<annotation encoding="application / x-tex">(1R,2R)-1,1< / annotation>< / semantics>< / com:Math>'- bicyclopropyl-2-yl). The term "cycloalkoxy" denotes cycloalkyl attached to and linked through an oxygen atom including, for example, cyclopentyloxy and cyclohexyloxy. The term "cycloalkoxyalkyl" denotes cycloalkoxy substitution on an alkyl moiety. Examples of "cycloalkoxyalkyl" include cyclopropyloxymethyl, cyclopentyloxyethyl, and other cycloalkoxy groups bonded to a straight-chain or branched alkyl moiety. The term "cycloalkylaminoalkyl" denotes cycloalkylamino substitution on an alkyl group. Examples of "cycloalkylaminoalkyl" include cyclopropylaminomethyl, cyclopentylaminoethyl, and other cycloalkylamino moieties bonded to a straight-chain or branched alkyl group. "Cycloalkylcarbonyl" denotes cycloalkyl bonded to a C(=O) group including, for example, cyclopropylcarbonyl and cyclopentylcarbonyl. Cycloalkylcarbonyloxy" denotes cycloalkylcarbonyl attached to and linked through an oxygen atom. Examples of "cycloalkylcarbonyloxy" include cyclohexylcarbonyloxy and cyclopentylcarbonyloxy. The term "cycloalkoxycarbonyl" means cycloalkoxy bonded to a <com:Math><semantics>C(=0)<annotation encoding="application / x-tex">C(=0)< / annotation>< / semantics>< / com:Math> group, for example, cyclopropyloxycarbonyl and cyclopentyloxycarbonyl. "Cycloalkylaminocarbonylamino" 16 denotes cycloalkylamino bonded to a <com:Math><semantics>C(=O)NH<annotation encoding="application / x-tex">C(=O)NH< / annotation>< / semantics>< / com:Math> group, for example, cyclopentylaminocarbonylamino and cyclohexylaminocarbonylamino. The term "halogen", either alone or in compound words such as "haloalkyl", or when used in descriptions such as "alkyl substituted with halogen" includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl", or when used in descriptions such as "alkyl substituted with halogen" said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of "haloalkyl" or "alkyl substituted with halogen" include F<com:Sub>3< / com:Sub>C, ClCH<com:Sub>2< / com:Sub>, CF<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub> and CF<com:Sub>3< / com:Sub>CCl<com:Sub>2< / com:Sub>. The terms "haloalkenyl", "haloalkynyl" "haloalkoxy", "haloalkylsulfonyl", "halocycloalkyl", and the like, are defined analogously to the term "haloalkyl". Examples of "haloalkenyl" include Cl<com:Sub>2< / com:Sub>C=CHCH<com:Sub>2< / com:Sub> and CF<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH=CHCH<com:Sub>2< / com:Sub>. Examples of "haloalkynyl" include <com:Math><semantics>HC=CCHCl<annotation encoding="application / x-tex">HC = CCHCl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CF3C=C<annotation encoding="application / x-tex">CF_3C = C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CCl3C=C<annotation encoding="application / x-tex">CCl_3C = C< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>FCH2C=CCH2<annotation encoding="application / x-tex">FCH_2C = CCH_2< / annotation>< / semantics>< / com:Math>. Examples of "haloalkoxy" include CF<com:Sub>3< / com:Sub>O, CCl<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>O, F<com:Sub>2< / com:Sub>CHCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O and CF<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>O. Examples of "haloalkylsulfonyl" include <com:Math><semantics>CF3S(=O)2<annotation encoding="application / x-tex">CF_3S(=O)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CCl3S(=O)2<annotation encoding="application / x-tex">CCl_3S(=O)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>CF3CH2S(=O)2<annotation encoding="application / x-tex">CF_3CH_2S(=O)_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>CF3CF2S(=O)2<annotation encoding="application / x-tex">CF_3CF_2S(=O)_2< / annotation>< / semantics>< / com:Math>. Examples of "halocycloalkyl" include 2-chlorocyclopropyl, 2-fluorocyclobutyl, 3-bromocyclopentyl and 4-chorocyclohexyl. "Cyanoalkyl" denotes an alkyl group substituted with one cyano group. Examples of "cyanoalkyl" include NCCH<com:Sub>2< / com:Sub>, NCCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH(CN)CH<com:Sub>2< / com:Sub>. "Hydroxyalkyl" denotes an alkyl group substituted with one hydroxy group. Examples of "hydroxyalkyl" include HOCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>(OH)CH and HOCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>. The total number of carbon atoms in a substituent group is indicated by the "C<com:Sub>i< / com:Sub>-C<com:Sub>i< / com:Sub>" prefix where i and j are numbers from 1 to 14. For example, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylsulfonyl designates methylsulfonyl through butylsulfonyl; C<com:Sub>2< / com:Sub> alkoxyalkyl designates CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>; C<com:Sub>3< / com:Sub> alkoxyalkyl designates, for example, CH<com:Sub>3< / com:Sub>CH(OCH<com:Sub>3< / com:Sub>), CH<com:Sub>3< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub> or CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>; and C<com:Sub>4< / com:Sub> alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub> and CH<com:Sub>3< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>. The term "unsubstituted" in connection with a group such as a ring or ring system means the group does not have any substituents other than its one or more attachments to the remainder of Formula 1. The term "optionally substituted" means that the number of substituents can be zero. Unless otherwise indicated, optionally substituted groups may be substituted with as many optional substituents as can be accommodated by replacing a hydrogen atom with a non-hydrogen substituent on any available carbon or nitrogen atom. Commonly, the number of optional substituents (when present) ranges from 1 to 3. As used herein, the term "optionally substituted" is used interchangeably with the phrase "substituted" or unsubstituted" or with the term "(un)substituted." The number of optional substituents may be restricted by an expressed limitation. For example, the phrase "optionally substituted with up to 3 substituents independently selected 17 from R<com:Sup>2< / com:Sup>" means that 0, 1, 2 or 3 substituents can be present (if the number of potential connection points allows). When a range specified for the number of substituents (e.g., x being an integer from 0 to 2 in Exhibit A) exceeds the number of positions available for substituents on a ring (e.g., 1 position available for <com:Math><semantics>(R2)x<annotation encoding="application / x-tex">(R^2)_x< / annotation>< / semantics>< / com:Math> on U-7 in Exhibit A), the actual higher end of the range is recognized to be the number of available positions. When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can vary (e.g., <com:Math><semantics>(R2)x<annotation encoding="application / x-tex">(R^2)_x< / annotation>< / semantics>< / com:Math> in Exhibit A wherein x is 1 to 2), then said substituents are independently selected from the group of defined substituents, unless otherwise indicated. When a variable group is shown to be optionally attached to a position, for example <com:Math><semantics>(R2)x<annotation encoding="application / x-tex">(R^2)_x< / annotation>< / semantics>< / com:Math> in Exhibit A wherein x may be 0, then hydrogen may be at the position even if not recited in the definition of the variable group. Naming of substituents in the present disclosure uses recognized terminology providing conciseness in precisely conveying to those skilled in the art the chemical structure. For sake of conciseness, locant descriptors may be omitted. Unless otherwise indicated, a "ring" or "ring system" as a component of Formula 1 (e.g., R<com:Sup>1< / com:Sup> and J) is carbocyclic or heterocyclic. The term "ring system" denotes two or more connected rings. The term "spirocyclic ring system" denotes a ring system consisting of two rings connected at a single atom (so the rings have a single atom in common). The term "bicyclic ring system" denotes a ring system consisting of two rings sharing two or more common atoms. In a "fused bicyclic ring system" the common atoms are adjacent, and therefore the rings share two adjacent atoms and a bond connecting them. The term "ring member" refers to an atom (e.g., C, O, N or S) or other moiety (e.g., <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>) forming the backbone of a ring or ring system. The term "aromatic" indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and that <com:Math><semantics>(4n+2)π<annotation encoding="application / x-tex">(4n + 2) \pi< / annotation>< / semantics>< / com:Math> electrons, where n is a positive integer, are associated with the ring to comply with Hückel's rule The term "carbocyclic ring" denotes a ring wherein the atoms forming the ring backbone are selected only from carbon. Unless otherwise indicated, a carbocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated carbocyclic ring satisfies Hückel's rule, then said ring is also called an "aromatic ring". "Saturated carbocyclic" refers to a ring having a backbone consisting of carbon atoms linked to one another by single bonds; unless otherwise specified, the remaining carbon valences are occupied by hydrogen atoms. As used herein, the term "partially unsaturated ring" or "partially unsaturated" heterocycle" refers to a ring which contains unsaturated ring atoms and one or more double bonds but is not aromatic. The terms "heterocyclic ring" or "heterocycle" denotes a ring wherein at least one of the atoms forming the ring backbone is other than carbon. Unless otherwise indicated, a heterocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated heterocyclic ring satisfies Hückel's rule, then said ring is also called a "heteroaromatic ring" or aromatic heterocyclic ring. "Saturated heterocyclic ring" refers to a heterocyclic ring containing only single bonds between ring members. Unless otherwise indicated, heterocyclic rings and ring systems are attached to the remainder of Formula 1 through any available carbon or nitrogen atom by replacement of a hydrogen on said carbon or nitrogen atom. Compounds of this invention can exist as one or more stereoisomers. Stereoisomers are isomers of identical constitution but differing in the arrangement of their atoms in space and include enantiomers, diastereomers, cis- and trans-isomers (also known as geometric isomers) and atropisomers. Atropisomers result from restricted rotation about single bonds where the rotational barrier is high enough to permit isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and / or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and / or to selectively prepare said stereoisomers. For a comprehensive discussion of all aspects of stereoisomerism, see Ernest L. Eliel and Samuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley & Sons, 1994. Compounds of this invention can exist as one or more conformational isomers due to restricted rotation about an amide bond (e.g., C(=O)-N) in Formula 1. This invention comprises mixtures of conformational isomers. In addition, this invention includes compounds that are enriched in one conformer relative to others. This invention comprises all stereoisomers, conformational isomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds. One skilled in the art will appreciate that not all nitrogen containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethyldioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, 19 Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press. One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding nonsalt forms, salts share the biological utility of the nonsalt forms. Thus a wide variety of salts of the compounds of Formula 1 are useful for control of plant diseases caused by fungal plant pathogens (i.e. are agriculturally suitable). The salts of the compounds of Formula 1 include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula 1 contains an acidic moiety such as a carboxylic acid, salts also include those formed with organic or inorganic bases such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention comprises compounds selected from Formula 1, N-oxides and agriculturally suitable salts, solvates and hydrates thereof. Compounds selected from Formula 1, stereoisomers, tautomers, N-oxides, and salts thereof, typically exist in more than one form, and Formula 1 thus includes all crystalline and non-crystalline forms of the compounds that Formula 1 represents. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The term "polymorph" refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and / or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co- crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound represented by Formula 1 can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound represented by Formula 1. Preparation and isolation of a particular polymorph of a compound represented by Formula 1 can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. For a comprehensive discussion of polymorphism see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006. The compounds herein, and the agriculturally acceptable salts thereof, may exist in a continuum of solid states ranging from fully amorphous to fully crystalline. They may also exist in unsolvated and solvated forms. The term "solvate" describes a molecular complex comprising the compound and one or more agriculturally acceptable solvent molecules (e.g., EtOH). The term "hydrate" is a solvate in which the solvent is water. Agriculturally acceptable solvates include those in which the solvent may be isotopically substituted (e.g., <com:Math><semantics>D2O<annotation encoding="application / x-tex">D_2O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>d6<annotation encoding="application / x-tex">d_6< / annotation>< / semantics>< / com:Math>-acetone, <com:Math><semantics>d6<annotation encoding="application / x-tex">d_6< / annotation>< / semantics>< / com:Math>-DMSO). A currently accepted classification system for solvates and hydrates of organic compounds is one that distinguishes between isolated site, channel, and metal-ion coordinated solvates and hydrates. See, e.g., K. R. Morris (H. G. Brittain ed.) Polymorphism in Pharmaceutical Solids (1995). Isolated site solvates and hydrates are ones in which the solvent (e.g., water) molecules are isolated from direct contact with each other by intervening molecules of the organic compound. In channel solvates, the solvent molecules lie in lattice channels where they are next to other solvent molecules. In metal-ion coordinated solvates, the solvent molecules are bonded to the metal ion. Embodiments of the present invention as described in the Summary of the Invention include those described below. In the following Embodiments, Formula 1 includes stereoisomers, N-oxides, hydrates, and salts thereof, and reference to "a compound of Formula 1" includes the definitions of substituents specified in the Summary of the Invention unless further defined in the Embodiments. Embodiment 1. A compound of Formula 1 wherein R<com:Sup>1< / com:Sup> is selected from U-1 through U-118 as depicted in Exhibit A Exhibit A [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>∧<annotation encoding="application / x-tex">\wedge< / annotation>< / semantics>< / com:Math> wherein the floating bond is connected to L in Formula 1 through any available carbon or nitrogen atom of the depicted ring or ring system; and x is 0, 1 or 2. Embodiment 2. A compound of Embodiment 1 wherein R<com:Sup>1< / com:Sup> is U-1 through U-16, U-20, U-22, U-24, U-25, U-26, U-28, U-29, U-30, U-37, U-38, U-42 through U-47 or U-71 through U-114. Embodiment 3. A compound of Embodiment 2 wherein R<com:Sup>1< / com:Sup> is U-12, U-24, U-26, U-28, U-29, U-30, U-37, U-38, U-42 through U-46, U-71, U-74, U-76, U-77, U-78, U-82, U-83, U-84 through U-91, U-93 through U-96, U-99 or U-101 through U-114. Embodiment 4. A compound of Embodiment 3 wherein R<com:Sup>1< / com:Sup> is U-12, U-24, U-26, U-28, U-29, U-30, U-42 through U-46, U-71, U-76, U-77, U-78, U-82, U-83, U-84, U-89, U-90, U-91, U-93, U-103, U-104 or U-109 through U-112. Embodiment 5. A compound of Embodiment 4 wherein R<com:Sup>1< / com:Sup> is U-12, U-26, U-29, U-30, U-42 through U-46, U-71, U-76, U-77, U-78, U-82, U-83, U-89, U-90, U-103 or U-104. Embodiment 6. A compound of Embodiment 5 wherein R<com:Sup>1< / com:Sup> is U-12, U-29, U-42, U-43, U-71, U-76, U-77, U-89, U-90, U-103 or U-104. Embodiment 7. A compound of Embodiment 6 wherein R<com:Sup>1< / com:Sup> is U-12, U-29, U-89 or U-90. Embodiment 8. A compound of Embodiment 7 wherein R<com:Sup>1< / com:Sup> is U-89. Embodiment 9. A compound of Embodiment 7 wherein R<com:Sup>1< / com:Sup> is U-90. Embodiment 10. A compound of Embodiment 1 wherein R<com:Sup>1< / com:Sup> is U-1, U-2, U-4, U-5, U-8, U-12, U-29, U-58, U-69, U-79, U-80, U-104, U-115, U-116, U-117 or U-118. Embodiment 11. A compound of Embodiment 10 wherein R<com:Sup>1< / com:Sup> is U-1, U-2, U-4, U-5, U-12 or U-29. Embodiment 12. A compound of Embodiment 11 wherein R<com:Sup>1< / com:Sup> is U-1, U-2, U-12 or U-29. Embodiment 13. A compound of Embodiment 12 wherein R<com:Sup>1< / com:Sup> is U-2 or U-12. Embodiment 14. A compound of Embodiment 12 wherein R<com:Sup>1< / com:Sup> is U-1. Embodiment 14a. A compound of Embodiment 14 wherein U-1 is connected at its 2-position to L. Embodiment 14b. A compound of Embodiment 14 wherein U-1 is connected at its 5-position to L. Embodiment 15. A compound of Embodiment 12 wherein R<com:Sup>1< / com:Sup> is U-2. Embodiment 15a. A compound of Embodiment 15 wherein U-2 is connected at its 2-position to L. Embodiment 15b. A compound of Embodiment 15 wherein U-2 is connected at its 4-position to L. Embodiment 15c. A compound of Embodiment 15 wherein U-2 is connected at its 5-position to L. Embodiment 16. A compound of Embodiment 12 wherein R<com:Sup>1< / com:Sup> is U-12. Embodiment 16a. A compound of Embodiment 16 wherein U-12 is connected at its 1-position to L. Embodiment 16b. A compound of Embodiment 16 wherein U-12 is connected at its 3-position to L. Embodiment 16c. A compound of Embodiment 16 wherein U-12 is connected at its 4-position to L. Embodiment 17. A compound of Embodiment 12 wherein R<com:Sup>1< / com:Sup> is U-29. Embodiment 17a. A compound of Embodiment 17 wherein U-29 is connected at its 5-position to L. Embodiment 18. A compound of any one of Embodiments 1 through 17a wherein x is 1 or 2. Embodiment 19. A compound of Embodiment 18 wherein x is 1. Embodiment 20. A compound of Embodiment 18 wherein x is 2. Embodiment 21. A compound of Formula 1 or any one of Embodiments 1 through 20 wherein L is O, (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or <com:Math><semantics>CH2OCH2<annotation encoding="application / x-tex">CH_2OCH_2< / annotation>< / semantics>< / com:Math>, wherein the atom to the left is connected to <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math>, and the atom to the right is connected to J, each carbon atom is optionally substituted with up to 2 substituents independently selected from halogen, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy. Embodiment 22. A compound of Embodiment 21 wherein L is (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, wherein the atom to the left is connected to R<com:Sup>1< / com:Sup>, and the atom to the right is connected to J, each carbon atom is optionally substituted with up to 1 substituent selected from halogen, cyano, hydroxy, methyl, halomethyl or methoxy. Embodiment 23. A compound of Embodiment 22 wherein L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>OCH2<annotation encoding="application / x-tex">OCH_2< / annotation>< / semantics>< / com:Math>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, wherein the atom to the left is connected to <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math>, and the atom to the right is connected to J. Embodiment 24. A compound of Formula 1 or any one of Embodiments 1 through 21 wherein L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>OCH2<annotation encoding="application / x-tex">OCH_2< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH2O<annotation encoding="application / x-tex">CH_2O< / annotation>< / semantics>< / com:Math>, wherein the atom to the left is connected to R<com:Sup>1< / com:Sup>, and the atom to the right is connected to J, each carbon atom optionally substituted with up to 2 substituents independently selected from halogen, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxy and C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkoxy. Embodiment 25. A compound of Embodiment 24 wherein L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>OCH2<annotation encoding="application / x-tex">OCH_2< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH2O<annotation encoding="application / x-tex">CH_2O< / annotation>< / semantics>< / com:Math>, wherein the atom to the left is connected to <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math>, and the atom to the right is connected to J, each carbon atom optionally substituted with up to 1 substituent selected from halogen, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy. Embodiment 26. A compound of Embodiment 25 wherein L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>OCH2<annotation encoding="application / x-tex">OCH_2< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>CH2O<annotation encoding="application / x-tex">CH_2O< / annotation>< / semantics>< / com:Math>, wherein the atom to the left is connected to <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math>, and the atom to the right is connected to J. Embodiment 27. A compound of Embodiment 25 wherein L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>. Embodiment 28. A compound of Formula 1 or any one of Embodiments 1 through 27 wherein n is 1 or 2. Embodiment 29. A compound of Embodiment 28 wherein n is 1. Embodiment 30. A compound of Embodiment 28 wherein n is 2. Embodiment 31. A compound of Formula 1 or any one of Embodiments 1 through 27 wherein n is 3. Embodiment 32. A compound of Formula 1 or any one of Embodiments 1 through 31 wherein J is a phenyl ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>; or a 3- to 7-membered carbocyclic ring, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>; or a 5- to 6-membered heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>5< / com:Sup>. Embodiment 33. A compound of Formula 1 or any one of Embodiments 1 through 32 wherein J is selected from J-1 through J-93 as depicted in Exhibit B Exhibit B [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] - [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 50 0 10 wherein the bond projecting to the left is bonded to L, and the bond projecting to the right is bonded to the oxadiazole ring in Formula 1; and each <com:Math><semantics>R5a<annotation encoding="application / x-tex">R^{5a}< / annotation>< / semantics>< / com:Math> is independently H or R<com:Sup>5< / com:Sup>; provided that at most only two R<com:Sup>5a< / com:Sup> substituents are other than H. Embodiment 34. A compound of Embodiment 33 wherein J is J-1 through J-5, J-17, J-18, J-37 through J-41, J-60, J-63 through J-71, J-73, J-74, J-75 or J-77 through J-85. Embodiment 35. A compound of Embodiment 34 wherein J is J-4, J-5, J-18, J-37, J-40, J-41, J-63 through J-69, J-73 or J-77 through J-85. Embodiment 36. A compound of Embodiment 35 wherein J is J-4, J-18, J-37, J-40, J-63 through J-69 or J-73. Embodiment 37. A compound of Embodiment 36 wherein J is J-37, J-40 or J-63 through J-67. Embodiment 38. A compound of Embodiment 37 wherein J is J-37. Embodiment 39. A compound of Embodiment 37 wherein J is J-40. Embodiment 40. A compound of Embodiment 37 wherein J is J-63 through J-65. Embodiment 41. A compound of Embodiment 40 wherein J is J-63. Embodiment 42. A compound of Embodiment 40 wherein J is J-64. Embodiment 43. A compound of Embodiment 33 wherein J is J-4, J-18, J-27, J-40, J-41, J-63, J-73 or J-93. Embodiment 44. A compound of Embodiment 43 wherein J is J-4, J-18, J-27, J-40 or J-63. Embodiment 45. A compound of Embodiment 44 wherein J is J-27, J-40 or J-63. Embodiment 45a. A compound of Embodiment 45 wherein J is J-40 or J-63. Embodiment 46. A compound of Embodiment 45 wherein J is J-27. Embodiment 47. A compound of Embodiment 45 wherein J is J-40. Embodiment 48. A compound of Embodiment 45 wherein J is J-63. Embodiment 49. A compound of any one of Embodiments 33 through 48 wherein R<com:Sup>5a< / com:Sup> is H, cyano, halogen, methyl or methoxy. Embodiment 50. A compound of Embodiment 49 wherein R<com:Sup>5a< / com:Sup> is H, halogen, methyl or methoxy. Embodiment 51. A compound of Embodiment 50 wherein R<com:Sup>5a< / com:Sup> is H, methyl or methoxy. Embodiment 52. A compound of Embodiment 51 wherein R<com:Sup>5a< / com:Sup> is H. Embodiment 53. A compound of Formula 1 or anyone of Embodiments 1 through 52 wherein each R<com:Sup>2< / com:Sup> is independently halogen, cyano, -NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>, -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>, <com:Math><semantics>−C(=S)NR3aR3b<annotation encoding="application / x-tex">-C(=S)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C3−C7<annotation encoding="application / x-tex">C_3-C_7< / annotation>< / semantics>< / com:Math> cycloalkyl, <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonyloxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylaminocarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonylamino or <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C7<annotation encoding="application / x-tex">C_7< / annotation>< / semantics>< / com:Math> cycloalkylaminocarbonylamino, each optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>. Embodiment 54. A compound of Embodiment 53 wherein each R<com:Sup>2< / com:Sup> is independently cyano, <com:Math><semantics>−NR3aR3b<annotation encoding="application / x-tex">-NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)NR3aR3b<annotation encoding="application / x-tex">-C(=S)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C3<annotation encoding="application / x-tex">C_1-C_3< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyloxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>5< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylaminocarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonylamino or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylaminocarbonylamino, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>. Embodiment 55. A compound of Embodiment 54 wherein each R<com:Sup>2< / com:Sup> is independently <com:Math><semantics>−NR3aR3b<annotation encoding="application / x-tex">-NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)NR3aR3b<annotation encoding="application / x-tex">-C(=S)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>); or <com:Math><semantics>C1−C3<annotation encoding="application / x-tex">C_1-C_3< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyloxy, C2-C3 alkylcarbonyl, C2-C3 alkoxycarbonyl, C3-C4 alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>5< / com:Sub> cycloalkoxycarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyloxy, each optionally substituted with up to 1 substituent selected from R<com:Sup>10< / com:Sup>. Embodiment 56. A compound of Formula 1 or anyone of Embodiments 1 through 53 wherein each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>. Embodiment 56a. A compound of Embodiment 56 wherein each R<com:Sup>2< / com:Sup> is independently halogen, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 3 substituents independently selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>. Embodiment 56b. A compound of Embodiment 56a wherein each R<com:Sup>2< / com:Sup> is independently halogen, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkenyloxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 3 substituents independently selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>. Embodiment 57. A compound of Embodiment 56 wherein each R<com:Sup>2< / com:Sup> is independently halogen, cyano, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or -U-V-Q; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkylcarbonylamino, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>10< / com:Sup>. Embodiment 58. A compound of Embodiment 57 wherein each R<com:Sup>2< / com:Sup> is independently halogen, cyano, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or -U-V-Q; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 1 substituent selected from R<com:Sup>10< / com:Sup>. Embodiment 59. A compound of Embodiment 58 wherein each R<com:Sup>2< / com:Sup> is independently halogen, cyano, <com:Math><semantics>−CH(=O)<annotation encoding="application / x-tex">-CH(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or -U-V-Q; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl or C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, each optionally substituted with up to 1 substituent selected from R<com:Sup>10< / com:Sup>. Embodiment 60. A compound of Embodiment 59 wherein each R<com:Sup>2< / com:Sup> is independently <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl, <com:Math><semantics>C3−C6<annotation encoding="application / x-tex">C_3-C_6< / annotation>< / semantics>< / com:Math> alkenyloxycarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>. Embodiment 61. A compound of Embodiment 60 wherein each R<com:Sup>2< / com:Sup> is independently <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl, <com:Math><semantics>C3−C6<annotation encoding="application / x-tex">C_3-C_6< / annotation>< / semantics>< / com:Math> alkenyloxycarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>. Embodiment 62. A compound of Embodiment 56 wherein each R<com:Sup>2< / com:Sup> is independently -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>; or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>. Embodiment 63. A compound of Embodiment 62 wherein each R<com:Sup>2< / com:Sup> is independently -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>; or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, optionally substituted with up to 2 substituents independently selected from R<com:Sup>10< / com:Sup>. Embodiment 64. A compound of Embodiment 63 wherein each R<com:Sup>2< / com:Sup> is independently -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>; or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, optionally substituted with up to 1 substituent selected from R<com:Sup>10< / com:Sup>. Embodiment 65. A compound of Embodiment 64 wherein each R<com:Sup>2< / com:Sup> is independently <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment 66. A compound of Formula 1 or any one of Embodiments 1 through 65 wherein <com:Math><semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics>< / com:Math> is H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 67. A compound of Embodiment 66 wherein R<com:Sup>3< / com:Sup> is H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 68. A compound of Embodiment 67 wherein R<com:Sup>3< / com:Sup> is H, cyano, hydroxy, methyl or methoxy. Embodiment 69. A compound of Embodiment 68 wherein R<com:Sup>3< / com:Sup> is H. Embodiment 70. A compound of Formula 1 or any one of Embodiments 1 through 69 wherein when each R<com:Sup>3a< / com:Sup> is separate (i.e. not taken together with R<com:Sup>3b< / com:Sup>), then each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl. Embodiment 71. A compound of Embodiment 70 wherein each R<com:Sup>3a< / com:Sup> is independently H, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>- C<com:Sub>5< / com:Sub> dialkylaminocarbonyl. Embodiment 72. A compound of Embodiment 71 wherein each R<com:Sup>3a< / com:Sup> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub> dialkylaminocarbonyl. Embodiment 73. A compound of Formula 1 or any one of Embodiments 1 through 69 wherein when each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is separate (i.e. not taken together with <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math>), then each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonyl or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonylalkyl. Embodiment 74. A compound of Embodiment 73 wherein each R<com:Sup>3a< / com:Sup> is independently H, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl. Embodiment 74a. A compound of Embodiment 74 wherein each R<com:Sup>3a< / com:Sup> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl. Embodiment 75. A compound of Embodiment 74 wherein each R<com:Sup>3a< / com:Sup> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxyalkyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl. Embodiment 76. A compound of Formula 1 or any one of Embodiments 1 through 75 wherein when each <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> is separate (i.e. not taken together with <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math>), then each <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> cycloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkoxyalkyl, C2-C6 haloalkoxyalkyl, C3-C8 alkoxyalkoxyalkyl, C2-C6 alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminoalkyl or C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> dialkylaminoalkyl. Embodiment 77. A compound of Embodiment 76 wherein each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylaminoalkyl or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> dialkylaminoalkyl. Embodiment 78. A compound of Embodiment 77 wherein each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl. Embodiment 79. A compound of Formula 1 or any one of Embodiments 1 through 75 wherein when each <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> is separate (i.e. not taken together with <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math>), then each <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> hydroxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> cyanoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl or C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> halotrialkylsilyl. Embodiment 80. A compound of Embodiment 79 wherein each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from cyano, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl. Embodiment 81. A compound of Embodiment 80 wherein each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl and C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl. Embodiment 82. A compound of Embodiment 81 wherein each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl and <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment 83. A compound of Embodiment 82 wherein each R<com:Sup>3b< / com:Sup> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkenyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl and <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment 84. A compound of Embodiment 83 wherein each R<com:Sup>3b< / com:Sup> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkenyl. Embodiment 85. A compound of Formula 1 or any one Embodiments 1 through 84 wherein when a pair of <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3b<annotation encoding="application / x-tex">R^{3b}< / annotation>< / semantics>< / com:Math> substituents attached to the same nitrogen atom are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 methyl. Embodiment 86. A compound of Embodiment 85 wherein a pair of R<com:Sup>3a< / com:Sup> and R<com:Sup>3b< / com:Sup> substituents attached to the same nitrogen atom are taken together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl. Embodiment 87. A compound of Formula 1 or any one of Embodiments 1 through 86 wherein when each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is separate (i.e. not taken together), then each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, cyano, hydroxy, methyl or methoxy. Embodiment 88. A compound of Embodiment 87 wherein each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, hydroxy, methyl or methoxy. Embodiment 89. A compound of Embodiment 88 wherein each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H or methyl. Embodiment 90. A compound of Embodiment 89 wherein each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is H. Embodiment 91. A compound of Formula 1 or any one of Embodiments 1 through 90 wherein each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is taken alone. Embodiment 92. A compound of Formula 1 or any one Embodiments 1 through 91 wherein when a pair of R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> substituents attached to the same carbon atom are taken together to form a ring, said ring is a cyclopropyl ring optionally substituted with up to 2 substituents independently selected from halogen, methyl, methoxy or methylthio. Embodiment 93. A compound of Embodiment 92 wherein a pair of R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> substituents attached to the same carbon atom are taken together to form a cyclopropyl ring. Embodiment 94. A compound of Formula 1 or any one of Embodiments 1 through 93 wherein each <com:Math><semantics>R5<annotation encoding="application / x-tex">R^5< / annotation>< / semantics>< / com:Math> is independently cyano, halogen, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 95. A compound of Embodiment 94 wherein each R<com:Sup>5< / com:Sup> is independently cyano, halogen, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 96. A compound of Embodiment 95 wherein each R<com:Sup>5< / com:Sup> is independently cyano, halogen, methyl or methoxy. Embodiment 97. A compound of Embodiment 96 wherein each R<com:Sup>5< / com:Sup> is independently methyl or methoxy. Embodiment 98. A compound of Formula 1 or any one of Embodiments 1 through 97 wherein each R<com:Sup>6< / com:Sup> is independently H, cyano, , halogen methyl or methoxy. Embodiment 99. A compound of Embodiment 98 wherein each R<com:Sup>6< / com:Sup> is independently H, Cl or methyl. Embodiment 100. A compound of Embodiment 99 wherein each R<com:Sup>6< / com:Sup> is independently H or methyl. Embodiment 101. A compound of Embodiment 100 wherein each R<com:Sup>6< / com:Sup> is H. Embodiment 102. A compound of Formula 1 or any one of Embodiments 1 through 101 wherein each R<com:Sup>7< / com:Sup> is independently hydroxy, NR<com:Sup>11a< / com:Sup>R<com:Sup>11b< / com:Sup>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyloxy. Embodiment 103. A compound of Embodiment 102 wherein each R<com:Sup>7< / com:Sup> is independently hydroxy, <com:Math><semantics>NR11aR11b<annotation encoding="application / x-tex">NR^{11a}R^{11b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 104. A compound of Embodiment 103 wherein each R<com:Sup>7< / com:Sup> is independently hydroxy, NR<com:Sup>11a< / com:Sup>R<com:Sup>11b< / com:Sup> or methoxy. Embodiment 105. A compound of Embodiment 104 wherein each R<com:Sup>7< / com:Sup> is hydroxy. Embodiment 106. A compound of Formula 1 or any one of Embodiments 1 through 101 wherein each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently hydroxy or <com:Math><semantics>NR11aR11b<annotation encoding="application / x-tex">NR^{11a}R^{11b}< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyloxy, each optionally substituted with up to 1 substituent selected cyano, hydroxy and <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>. Embodiment 107. A compound of Embodiment 106 wherein each R<com:Sup>7< / com:Sup> is independently <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyloxy, each optionally substituted with up to 1 substituent selected cyano, hydroxy and <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>. Embodiment 108. A compound of Embodiment 107 wherein each R<com:Sup>7< / com:Sup> is independently <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyloxy. Embodiment 109. A compound of Formula 1 or any one of Embodiments 1 through 108 wherein each R<com:Sup>8< / com:Sup> is independently H, methyl or methoxy. Embodiment 110. A compound of Embodiment 109 wherein each R<com:Sup>8< / com:Sup> is independently H or methyl. Embodiment 111. A compound of Embodiment 110 wherein each R<com:Sup>8< / com:Sup> is H. Embodiment 112. A compound of Formula 1 or any one of Embodiments 1 through 111 wherein when each R<com:Sup>9a< / com:Sup> and R<com:Sup>9b< / com:Sup> is separate (i.e. not taken together), then each R<com:Sup>9a< / com:Sup> and R<com:Sup>9b< / com:Sup> is independently H, methyl or ethyl. Embodiment 113. A compound of Embodiment 112 wherein each R<com:Sup>9a< / com:Sup> and R<com:Sup>9b< / com:Sup> is independently H or methyl. Embodiment 114. A compound of Formula 1 or any one Embodiments 1 through 113 wherein when a pair of <com:Math><semantics>R9a<annotation encoding="application / x-tex">R^{9a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R9b<annotation encoding="application / x-tex">R^{9b}< / annotation>< / semantics>< / com:Math> substituents are taken together with the nitrogen atom to which they are attached to form a 5- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 methyl. Embodiment 115. A compound of Embodiment 114 wherein a pair of <com:Math><semantics>R9a<annotation encoding="application / x-tex">R^{9a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R9b<annotation encoding="application / x-tex">R^{9b}< / annotation>< / semantics>< / com:Math> are substituents taken together with the nitrogen atom to which they are attached to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl, or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl. Embodiment 116. A compound of Formula 1 or any one of Embodiments 1 through 115 wherein each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, hydroxy, nitro, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxyalkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylthio, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylsulfinyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl. Embodiment 117. A compound of Embodiment 116 wherein each R<com:Sup>10< / com:Sup> is independently halogen, cyano, hydroxy, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl. Embodiment 118. A compound of Embodiment 117 wherein each R<com:Sup>10< / com:Sup> is independently halogen, hydroxy, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>3< / com:Sub> alkoxycarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylaminocarbonyl or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> dialkylaminocarbonyl. Embodiment 119. A compound of Formula 1 or any one of Embodiments 1 through 115 wherein each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> halocycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkylthioalkylcarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsily or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>. Embodiment 120. A compound of Embodiment 119 wherein each R<com:Sup>10< / com:Sup> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>. Embodiment 121. A compound of Embodiment 120 wherein each R<com:Sup>10< / com:Sup> is independently halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>. Embodiment 122. A compound of Embodiment 121 wherein each R<com:Sup>10< / com:Sup> is independently halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonyl or -<com:Math><semantics>C(R13)<annotation encoding="application / x-tex">C(R^{13})< / annotation>< / semantics>< / com:Math>=<com:Math><semantics>NOR14<annotation encoding="application / x-tex">NOR^{14}< / annotation>< / semantics>< / com:Math>. Embodiment 123. A compound of Embodiment 122 wherein each R<com:Sup>10< / com:Sup> is independently halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl. Embodiment 124. A compound of Formula 1 or any one of Embodiments 1 through 123 wherein each U is independently a direct bond, <com:Math><semantics>C(=O)O<annotation encoding="application / x-tex">C(=O)O< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C(=O)NR17<annotation encoding="application / x-tex">C(=O)NR^{17}< / annotation>< / semantics>< / com:Math>. Embodiment 125. A compound of Embodiment 124 wherein each U is a direct bond. Embodiment 126. A compound of Embodiment 125 wherein each U is independently <com:Math><semantics>C(=O)O<annotation encoding="application / x-tex">C(=O)O< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C(=O)NR17<annotation encoding="application / x-tex">C(=O)NR^{17}< / annotation>< / semantics>< / com:Math>. Embodiment 127. A compound of Formula 1 or any one of Embodiments 1 through 126 wherein each V is independently a direct bond; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylene, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenylene or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynylene, each optionally substituted with up to 2 substituents independently selected from halogen, cyano, nitro, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy. Embodiment 128. A compound of Embodiment 127 wherein each V is independently a direct bond; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylene, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenylene or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynylene, each optionally substituted with up to 2 substituents independently selected from halogen, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy. Embodiment 129. A compound of Embodiment 128 wherein each V is independently a direct bond, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylene, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenylene or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynylene. Embodiment 130. A compound of Embodiment 129 wherein each V is independently a direct bond, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylene or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenylene. Embodiment 131. A compound of Embodiment 130 wherein each V is a direct bond. Embodiment 132. A compound of Embodiment 130 wherein each V is independently <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylene. Embodiment 133. A compound of Formula 1 or any one of Embodiments 1 through 132 wherein each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or a 3- to 7-membered nonaromatic heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 2 substituents independently selected from <com:Math><semantics>R12<annotation encoding="application / x-tex">R^{12}< / annotation>< / semantics>< / com:Math>. Embodiment 134. A compound of Embodiment 133 wherein each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, thienyl, isoxazolinyl, piperidinyl, morpholinyl or piperazinyl, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>. Embodiment 135. A compound of Embodiment 134 wherein each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl or oxazolyl, each ring optionally substituted with up to 2 substituents independently selected from <com:Math><semantics>R12<annotation encoding="application / x-tex">R^{12}< / annotation>< / semantics>< / com:Math>. Embodiment 136. A compound of Embodiment 135 wherein each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or pyridinyl or pyrazolyl, each ring optionally substituted with up to 2 substituents independently selected from <com:Math><semantics>R12<annotation encoding="application / x-tex">R^{12}< / annotation>< / semantics>< / com:Math>. Embodiment 137. A compound of Formula 1 or any one of Embodiments 1 through 136 wherein when each <com:Math><semantics>R11a<annotation encoding="application / x-tex">R^{11a}< / annotation>< / semantics>< / com:Math> is separate (i.e. not taken together with <com:Math><semantics>R11b<annotation encoding="application / x-tex">R^{11b}< / annotation>< / semantics>< / com:Math>), then each <com:Math><semantics>R11a<annotation encoding="application / x-tex">R^{11a}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylcarbonyl. Embodiment 138. A compound of Embodiment 137 wherein each R<com:Sup>11a< / com:Sup> is independently H, methyl or methylcarbonyl. Embodiment 139. A compound of Formula 1 or any one of Embodiments 1 through 138 wherein when each R<com:Sup>11b< / com:Sup> is separate (i.e. not taken together with R<com:Sup>11a< / com:Sup>), then each R<com:Sup>11b< / com:Sup> is independently H, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl. Embodiment 140. A compound of Embodiment 139 wherein each R<com:Sup>11b< / com:Sup> is independently H, cyano, methyl, methylcarbonyl, methoxycarbonyl, methoxycarbonylmethyl, methylaminocarbonyl or dimethylaminocarbonyl. Embodiment 141. A compound of Embodiment 140 wherein each R<com:Sup>11b< / com:Sup> is independently H, methyl, methylcarbonyl or methoxycarbonyl. Embodiment 142. A compound of Formula 1 or any one Embodiments 1 through 141 wherein when a pair of R<com:Sup>11a< / com:Sup> and R<com:Sup>11b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form a 5- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 methyl. Embodiment 143. A compound of Embodiment 142 wherein a pair of R<com:Sup>11a< / com:Sup> and R<com:Sup>11b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl. Embodiment 144. A compound of Formula 1 or any one of Embodiments 1 through 143 wherein each R<com:Sup>12< / com:Sup> is independently halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 145. A compound of Embodiment 144 wherein each R<com:Sup>12< / com:Sup> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 146. A compound of Embodiment 145 wherein each R<com:Sup>12< / com:Sup> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy. Embodiment 147. A compound of Embodiment 146 wherein each R<com:Sup>12< / com:Sup> is independently halogen, methyl or methoxy. Embodiment 148. A compound of Formula 1 or any one Embodiments 1 through 147 wherein each R<com:Sup>13< / com:Sup> and R<com:Sup>15< / com:Sup> is independently H, cyano, halogen, methyl, halomethyl or methoxy. Embodiment 149. A compound of Embodiment 148 wherein each R<com:Sup>13< / com:Sup> and R<com:Sup>15< / com:Sup> is independently H, halogen, methyl or methoxy. Embodiment 150. A compound of Embodiment 149 wherein each R<com:Sup>13< / com:Sup> and R<com:Sup>15< / com:Sup> is H. Embodiment 151. A compound of Formula 1 or any one Embodiments 1 through 150 wherein each R<com:Sup>14< / com:Sup> is H, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl. Embodiment 152. A compound of Embodiment 151 wherein each R<com:Sup>14< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl. Embodiment 153. A compound of Embodiment 152 wherein each R<com:Sup>14< / com:Sup> is independently H, methyl, halomethyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment 154. A compound of Formula 1 or any one Embodiments 1 through 153 wherein each R<com:Sup>16< / com:Sup> is independently H, cyano, methyl, halomethyl, methoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment 155. A compound of Embodiment 154 wherein each R<com:Sup>16< / com:Sup> is independently H, cyano, methyl, halomethyl or methoxy. Embodiment 156. A compound of Embodiment 155 wherein each R<com:Sup>16< / com:Sup> is independently H or methyl. Embodiment 157. A compound of Embodiment 156 wherein each R<com:Sup>16< / com:Sup> is H. Embodiment 158. A compound of Formula 1 or any one Embodiments 1 through 157 wherein each R<com:Sup>17< / com:Sup> and R<com:Sup>18< / com:Sup> is independently H, cyano, methyl or halomethyl. Embodiments of this invention, including Embodiments 1-158 above as well as any other embodiments described herein, can be combined in any manner, and the descriptions of variables in the embodiments pertain not only to the compounds of Formula 1 but also to the starting compounds and intermediate compounds useful for preparing the compounds of Formula 1. In addition, embodiments of this invention, including Embodiments 1-158 above as well as any other embodiments described herein, and any combination thereof, pertain to the compositions and methods of the present invention. Combinations of Embodiments 1-158 are illustrated by: Embodiment A. A compound of Formula 1 wherein R<com:Sup>1< / com:Sup> is selected from U-1 through U-118 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] U-11 / U-110 wherein the floating bond is connected to L in Formula 1 through any available carbon or nitrogen atom of the depicted ring or ring system; x is 0, 1 or 2; L is O, (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, each carbon atom is optionally substituted with up to 2 substituents independently selected from halogen, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; J is selected from J-1 through J-93 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] wherein the bond projecting to the left is bonded to L, and the bond projecting to the right is bonded to the oxadiazole ring in Formula 1; each R<com:Sup>5a< / com:Sup> is independently H or R<com:Sup>5< / com:Sup>; provided that at most only two R<com:Sup>5a< / com:Sup> substituents are other than H; each R<com:Sup>2< / com:Sup> is independently halogen, cyano, -CH(=O), -C(=O)OH, -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C3−C7<annotation encoding="application / x-tex">C_3-C_7< / annotation>< / semantics>< / com:Math> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 3 substituents independently selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>; each R<com:Sup>3a< / com:Sup> is independently H, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonyl or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonylalkyl; each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> hydroxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> cyanoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl or C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> halotrialkylsilyl; or a pair of R<com:Sup>3a< / com:Sup> and R<com:Sup>3b< / com:Sup> substituents attached to the same nitrogen atom are taken together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl; each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, cyano, hydroxy, methyl or methoxy; or a pair of R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> substituents attached to the same carbon atom are taken together to form a cyclopropyl ring optionally substituted with up to 2 substituents independently selected from halogen, methyl, methoxy or methylthio; each <com:Math><semantics>R5<annotation encoding="application / x-tex">R^5< / annotation>< / semantics>< / com:Math> is independently cyano, halogen, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy; each R<com:Sup>6< / com:Sup> is independently H, cyano, halogen, methyl or methoxy; each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently hydroxy or <com:Math><semantics>NR11aR11b<annotation encoding="application / x-tex">NR^{11a}R^{11b}< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyloxy, each optionally substituted with up to 1 substituent selected cyano, hydroxy and <com:Math><semantics>−C(=O)OH<annotation encoding="application / x-tex">-C(=O)OH< / annotation>< / semantics>< / com:Math>; each R<com:Sup>10< / com:Sup> is independently halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> halocycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> 53 alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkylthioalkylcarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsily or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>; each U is independently a direct bond, <com:Math><semantics>C(=O)O<annotation encoding="application / x-tex">C(=O)O< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C(=O)NR17<annotation encoding="application / x-tex">C(=O)NR^{17}< / annotation>< / semantics>< / com:Math>; each V is independently a direct bond; or C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylene, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenylene or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynylene, each optionally substituted with up to 2 substituents independently selected from halogen, cyano, nitro, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, thienyl, isoxazolinyl, piperidinyl, morpholinyl or piperazinyl, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; each <com:Math><semantics>R11a<annotation encoding="application / x-tex">R^{11a}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylcarbonyl; each R<com:Sup>11b< / com:Sup> is independently H, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl; or a pair of R<com:Sup>11a< / com:Sup> and R<com:Sup>11b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl; each <com:Math><semantics>R12<annotation encoding="application / x-tex">R^{12}< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy; each R<com:Sup>13< / com:Sup> is independently H, cyano, halogen, methyl, halomethyl or methoxy; each R<com:Sup>14< / com:Sup> is H, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl; and each R<com:Sup>17< / com:Sup> is independently H, cyano, methyl or halomethyl. Embodiment B. A compound of Embodiment A wherein R<com:Sup>1< / com:Sup> is U-1, U-2, U-4, U-5, U-8, U-12, U-29, U-58, U-69, U-79, U-80, U-104, U-115, U- 116, U-117 or U-118; L is (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>; J is J-4, J-18, J-27, J-40, J-41, J-63, J-73 or J-93; each R<com:Sup>2< / com:Sup> is independently halogen, cyano, -CH(=O), -C(=O)OH, -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C3−C7<annotation encoding="application / x-tex">C_3-C_7< / annotation>< / semantics>< / com:Math> cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, each optionally substituted with up to 2 substituents independently selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>; 54 each R<com:Sup>3a< / com:Sup> is independently H, cyano, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkylcarbonyl or <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonylalkyl; each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from cyano, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl; each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, hydroxy, methyl or methoxy; each R<com:Sup>5< / com:Sup> is independently methyl or methoxy; each R<com:Sup>6< / com:Sup> is independently H or methyl; each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyloxy, each optionally substituted with up to 1 substituent selected cyano, hydroxy and <com:Math><semantics>−C(=O)OH;<annotation encoding="application / x-tex">-C(=O)OH;< / annotation>< / semantics>< / com:Math> each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>; each V is independently a direct bond, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkylene, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenylene or C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub> alkynylene; each R<com:Sup>12< / com:Sup> is independently halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl or C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkoxy; each R<com:Sup>13< / com:Sup> is independently H, halogen, methyl or methoxy; and each R<com:Sup>14< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>2< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment C. A compound of Embodiment B wherein R<com:Sup>1< / com:Sup> is U-1, U-2, U-12 or U-29; L is <com:Math><semantics>(CR4aR4b)n<annotation encoding="application / x-tex">(CR^{4a}R^{4b})_n< / annotation>< / semantics>< / com:Math>; J is J-27, J-40 or J-63; each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>; each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxyalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkylcarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl; each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> 55 halocycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl and <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl; each <com:Math><semantics>R4a<annotation encoding="application / x-tex">R^{4a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R4b<annotation encoding="application / x-tex">R^{4b}< / annotation>< / semantics>< / com:Math> is independently H or methyl; each R<com:Sup>6< / com:Sup> is independently H; each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyloxy; each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl or <com:Math><semantics>−C(R13)=NOR14<annotation encoding="application / x-tex">-C(R^{13})=NOR^{14}< / annotation>< / semantics>< / com:Math>; each V is independently a direct bond, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkylene or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenylene; each Q is independently phenyl, each optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl or oxazolyl, each ring optionally substituted with up to 2 substituents independently selected from R<com:Sup>12< / com:Sup>; each R<com:Sup>12< / com:Sup> is independently halogen, methyl or methoxy; and each R<com:Sup>14< / com:Sup> is independently H, methyl, halomethyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl or C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl. Embodiment D. A compound of Embodiment C wherein R<com:Sup>1< / com:Sup> is U-2 or U-12; J is J-40 or J-63; <com:Math><semantics>R5a<annotation encoding="application / x-tex">R^{5a}< / annotation>< / semantics>< / com:Math> is H: each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently -C(=O)NR<com:Sup>3a< / com:Sup>R<com:Sup>3b< / com:Sup>; or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, optionally substituted with up to 1 substituent selected from <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math>; each <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl; each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, each optionally substituted with up to 1 substituent selected from <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl and <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxycarbonyl; and each <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> is independently halogen, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkylcarbonyl or <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkoxycarbonyl. Embodiment E. A compound of Embodiment D wherein R<com:Sup>1< / com:Sup> is U-2 connected at its 2-position to L; or R<com:Sup>1< / com:Sup> is U-12 connected at its 1-position to L; each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently <com:Math><semantics>−C(=O)NR3aR3b<annotation encoding="application / x-tex">-C(=O)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C2−C6<annotation encoding="application / x-tex">C_2-C_6< / annotation>< / semantics>< / com:Math> alkoxycarbonyl; and n is 1. Embodiment F. A compound of Formula 1 wherein <com:Math><semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>< / com:Math> is a phenyl ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; provided that R<com:Sup>1< / com:Sup> is linked to L via a carbon atom ring member; J is [Image disponible dans le document PDF, Image available in the PDF document] J-63 wherein the bond projecting to the left is bonded to L, and the bond projecting to the right is bonded to the oxadiazole ring in Formula 1; each R<com:Sup>5a< / com:Sup> is independently H or R<com:Sup>5< / com:Sup>; provided that at most only two R<com:Sup>5a< / com:Sup> substituents are other than H; and n is 3. Embodiment G. A compound of Formula 1 wherein R<com:Sup>1< / com:Sup> is a phenyl ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; and each R<com:Sup>2< / com:Sup> is independently C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy or C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, each optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>. This invention provides a fungicidal composition comprising a compound of Formula 1 (including all stereoisomers, N-oxides, hydrates, and salts thereof), and at least one other fungicide. Of note as embodiments of such compositions are compositions comprising a compound corresponding to any of the compound embodiments described above. This invention provides a fungicidal composition comprising a compound of Formula 1 (including all stereoisomers, N-oxides, hydrates, and salts thereof) (i.e. in a fungicidally effective amount), and at least one additional component selected from the group consisting 57 of surfactants, solid diluents and liquid diluents. Of note as embodiments of such compositions are compositions comprising a compound corresponding to any of the compound embodiments described above. This invention provides a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1 (including all stereoisomers, N-oxides, hydrates, and salts thereof). Of note as embodiments of such methods are methods comprising applying a fungicidally effective amount of a compound corresponding to any of the compound embodiments describe above. Of particular note are embodiments where the compounds are applied as compositions of this invention. Of note are compounds of Formula 1 that are compounds of Formula 1G (including all geometric and stereoisomers), N-oxides, hydrates and salts thereof, and agricultural compositions containing them and their use as fungicides: [Image disponible dans le document PDF, Image available in the PDF document] wherein R<com:Sup>1< / com:Sup> is a phenyl ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; or R<com:Sup>1< / com:Sup> is a 3- to 7-membered nonaromatic ring or an 8- to 11-membered bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and optionally up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from <com:Math><semantics>C(=O)<annotation encoding="application / x-tex">C(=O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)<annotation encoding="application / x-tex">C(=S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>S(=O)<annotation encoding="application / x-tex">S(=O)< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S(=O)2<annotation encoding="application / x-tex">S(=O)_2< / annotation>< / semantics>< / com:Math>, each ring or ring system optionally substituted with up to 3 substituents independently selected from R<com:Sup>2< / com:Sup>; L is O, NR<com:Sup>3< / com:Sup>, NR<com:Sup>3< / com:Sup>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>NR<com:Sup>3< / com:Sup>, NR<com:Sup>3< / com:Sup>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>NR<com:Sup>3< / com:Sup>, (CR<com:Sup>4a< / com:Sup>R<com:Sup>4b< / com:Sup>)<com:Sub>n< / com:Sub>, OCH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>O, OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>, CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O or CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>, wherein the atom to the left is connected to R<com:Sup>1< / com:Sup>, and the atom to the right is connected to J, each carbon atom is optionally substituted with up to 2 substituents independently selected from halogen, cyano, hydroxy, nitro, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; J is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , or , J-4 J-18 J-40 wherein the bond projecting to the left is bonded to L, and the bond projecting to the right is bonded to the oxadiazole ring in Formula 1; each R<com:Sup>5a< / com:Sup> is independently H or R<com:Sup>5< / com:Sup>; each <com:Math><semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>< / com:Math> is independently halogen, cyano, hydroxy, nitro, thioyl, -SF<com:Sub>5< / com:Sub>, -CH(=O), [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−C(=S)NR3aR3b<annotation encoding="application / x-tex">-C(=S)NR^{3a}R^{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(R6)=NR7<annotation encoding="application / x-tex">-C(R^6)=NR^7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N=CR8NR9aR9b<annotation encoding="application / x-tex">-N=CR^8NR^{9a}R^{9b}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−U−V−Q<annotation encoding="application / x-tex">-U-V-Q< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1−C6<annotation encoding="application / x-tex">C_1-C_6< / annotation>< / semantics>< / com:Math> alkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkenyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxy, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthio, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminosulfinyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> dialkylaminosulfinyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonyloxy, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyloxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyloxycarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub> alkyloxycarbonylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonyloxy, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylaminocarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylcarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxycarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkoxycarbonylamino, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminocarbonylamino, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylaminocarbonylamino or C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> dialkoxyphosphinyl, each optionally substituted with up to 3 substituents independently selected from R<com:Sup>10< / com:Sup>; each <com:Math><semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3a<annotation encoding="application / x-tex">R^{3a}< / annotation>< / semantics>< / com:Math> is independently H, cyano, hydroxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylsulfonyl, C<com:Sub>2< / com:Sub>- C<com:Sub>4< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfinylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylsulfonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkylcarbonyl, C<com:Sub>4< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyl or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyl; each R<com:Sup>3b< / com:Sup> is independently H, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub> hydroxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> cyanoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> cycloalkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> halocycloalkenyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> halocycloalkylalkyl, C<com:Sub>6< / com:Sub>-C<com:Sub>14< / com:Sub> cycloalkylcycloalkyl, C<com:Sub>5< / com:Sub>-C<com:Sub>10< / com:Sub> alkylcycloalkylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkoxyalkyl, C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkoxyalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> alkoxyalkoxyalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylthioalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfinylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylsulfonylalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkylaminoalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> haloalkylaminoalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>8< / com:Sub> dialkylaminoalkyl or C<com:Sub>4< / com:Sub>-C<com:Sub>10< / com:Sub> cycloalkylaminoalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, nitro, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkylcarbonyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkoxycarbonyl, C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> trialkylsilyl and C<com:Sub>3< / com:Sub>-C<com:Sub>15< / com:Sub> halotrialkylsilyl; or a pair of R<com:Sup>3a< / com:Sup> and R<com:Sup>3b< / com:Sup> substituents are taken together with the nitrogen atom to which they are attached to form a 4- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 3 substituents independently selected from halogen and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> alkyl; each R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> is independently H, halogen, cyano, hydroxy, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub> alkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> alkoxy or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math> haloalkoxy; or a pair of R<com:Sup>4a< / com:Sup> and R<com:Sup>4b< / com:Sup> substituents attached to the same carbon atom are taken together to form a C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> cycloalkyl ring optionally substituted with up to 2 substituents independently selected from halogen, methyl, methoxy and methylthio; each R<com:Sup>5< / com:Sup> is independently hydroxy, cyano, nitro, halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub> haloalkyl, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy; each R<com:Sup>6< / com:Sup> is independently H, cyano, halogen, methyl, methoxy, methylthio or methoxycarbonyl; each <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is independently hydroxy or <com:Math><semantics>NR11aR11b<annotation encoding="application / x-tex">NR^{11a}R^{11b}< / annotation>< / semantics>< / com:Math>; or <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C2<annotation encoding="application / x-tex">C_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math> alkenyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkynyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub> alkylcarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkoxycarbonyloxy, C<com:Sub>2< / com:Sub>-C<com:Sub>5< / com:Sub> alkylaminocarbonyloxy or C<com:Sub>3< / com:Sub>-C<com:Sub>5< / com:Sub> dialkylaminocarbonyloxy, each optionally substituted with up to 1 substituent selected from halogen, cyano, hydroxy and <com:Math><semantics>−C(=O)OH;<anno...

Claims

1. A compound selected from Formula 1 tautomers, N-oxides, and salts thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein: R 1 R^1 is [Image disponible dans le document PDF, Image available in the PDF document] U-2 U-8 U-12 U-29 wherein the floating bond is connected to L in Formula 1 through any available carbon or nitrogen atom of the depicted ring; x is 1; L is ( C R 4 a R 4 b ) n (CR^{4a}R^{4b})_n or C H 2 O CH_2O ; J is [Image disponible dans le document PDF, Image available in the PDF document] , J-63 wherein the bond projecting to the left is bonded to L, and the bond projecting to the right is bonded to the oxadiazole ring in Formula 1; each R 5a is independently H; each R 2 R^2 is independently halogen, cyano or − C ( = O ) N R 3 a R 3 b -C(=O)NR^{3a}R^{3b} ; or C 1 − C 6 C_1-C_6 alkyl, C 2 − C 6 C_2-C_6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyloxy, C 2 -C 6 alkynyloxy, C 3 -C 7 cycloalkoxy, C 1 -C 6 alkylthio, C 2 -C 6 alkoxycarbonyl, C 3 -C 6 alkenyloxycarbonyl, C 3 -C 6 alkynyloxycarbonyl, C 4 -C 7 cycloalkoxycarbonyl, C 2 -C 6 177 alkylcarbonyloxy or C 2 -C 6 alkylcarbonylamino, each optionally substituted with up to 2 substituents independently selected from R 10 ; each R 3 a R^{3a} is independently H, cyano, hydroxy, C 1 C_1 - C 4 C_4 alkyl, C 1 C_1 - C 4 C_4 haloalkyl, C 2 C_2 - C 4 C_4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 2 -C 4 alkoxyalkyl, C 2 -C 4 alkylcarbonyl, C 2 -C 4 haloalkylcarbonyl or C 3 -C 5 alkoxycarbonylalkyl; each R 3 b R^{3b} is independently H, C 1 C_1 - C 6 C_6 alkyl, C 1 C_1 - C 6 C_6 haloalkyl, C 2 C_2 - C 6 C_6 alkenyl, C 2 C_2 - C 6 C_6 haloalkenyl, C 2 -C 6 alkynyl, C 2 -C 6 haloalkynyl, C 3 -C 8 halocycloalkyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 halocycloalkylalkyl, C 2 -C 6 alkoxyalkyl or C 2 -C 6 haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from cyano, C 2 C_2 - C 4 C_4 alkylcarbonyl and C 2 C_2 - C 4 C_4 alkoxycarbonyl; each R 4a and R 4b is independently H; each R 10 is independently halogen, cyano, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 - C 4 haloalkoxy, C 2 -C 4 alkoxyalkoxy, C 1 -C 4 alkylsulfonyl, C 1 -C 4 haloalkylsulfonyl, C 2 -C 4 alkylcarbonyl, C 2 -C 4 haloalkylcarbonyl or C 2 -C 5 alkoxycarbonyl; and n is 1; provided that: (a) the compound of Formula 1 is not [Image disponible dans le document PDF, Image available in the PDF document] wherein: m is 1; R 1a is at the 3-postion and is Cl; or m is 1; R 1 a R^{1a} is at the 4-postion and is halogen, cyano, C 2 C_2 - C 5 C_5 alkoxycarbonyl, N H 2 C ( = O ) NH_2C(=O) , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document]2. A compound of Claim 1 wherin: R 1 is U-2, U-12 or U-29; L is ( C R 4 a R 4 b ) n (CR^{4a}R^{4b})_n ; each R 2 R^2 is independently − C ( = O ) N R 3 a R 3 b -C(=O)NR^{3a}R^{3b} ; or C 2 − C 6 C_2-C_6 alkoxycarbonyl, C 3 − C 6 C_3-C_6 alkenyloxycarbonyl or C 3 -C 6 alkynyloxycarbonyl, each optionally substituted with up to 1 substituent selected from R 10 R^{10} ; each R 3 a R^{3a} is independently H, C 1 C_1 - C 4 C_4 alkyl, C 1 C_1 - C 4 C_4 haloalkyl, C 2 C_2 - C 4 C_4 alkenyl, C 2 C_2 - C 4 C_4 alkynyl, C 1 -C 4 alkoxy, C 2 -C 4 alkoxyalkyl, C 2 -C 4 alkylcarbonyl, C 2 -C 4 haloalkylcarbonyl or C 3 -C 5 alkoxycarbonylalkyl; each R 3 b R^{3b} is independently H, C 1 C_1 - C 6 C_6 alkyl, C 1 C_1 - C 6 C_6 haloalkyl, C 2 C_2 - C 6 C_6 alkenyl, C 2 C_2 - C 6 C_6 haloalkenyl, C 2 -C 6 alkynyl, C 2 -C 6 haloalkynyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 halocycloalkylalkyl, C 2 -C 6 alkoxyalkyl or C 2 -C 6 haloalkoxyalkyl, each optionally substituted with up to 1 substituent selected from C 2 -C 4 alkylcarbonyl and C 2 -C 4 alkoxycarbonyl; and each R 10 is independently halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 2 -C 4 alkylcarbonyl, C 2 -C 4 haloalkylcarbonyl or C 2 -C 5 alkoxycarbonyl.

3. A compound of Claim 2 wherein: R 1 is U-2 or U-12; each R 2 is independently -C(=O)NR 3a R 3b ; or C 2 -C 6 alkoxycarbonyl, optionally substituted with up to 1 substituent selected from R 10 ; each R 3 a R^{3a} is independently H, C 1 C_1 - C 4 C_4 alkyl, C 1 C_1 - C 4 C_4 haloalkyl, C 2 C_2 - C 4 C_4 alkenyl, C 2 C_2 - C 4 C_4 alkynyl, C 2 -C 4 alkoxyalkyl or C 3 -C 5 alkoxycarbonylalkyl; each R 3 b R^{3b} is independently H, C 1 C_1 - C 6 C_6 alkyl, C 1 C_1 - C 6 C_6 haloalkyl, C 2 C_2 - C 6 C_6 alkenyl or C 2 C_2 - C 6 C_6 haloalkenyl, each optionally substituted with up to 1 substituent selected from C 2 -C 4 alkylcarbonyl and C 2 -C 4 alkoxycarbonyl; and each R 10 R^{10} is independently halogen, C 1 C_1 - C 4 C_4 alkyl, C 1 C_1 - C 4 C_4 alkoxy, C 2 C_2 - C 4 C_4 alkylcarbonyl, C 2 C_2 - C 4 C_4 haloalkylcarbonyl or C 2 -C 5 alkoxycarbonyl.

4. A compound of Claim 3 wherein: R 1 is U-2 connected at its 2-position to L; or R 1 is U-12 connected at its 1-position to L; and each R 2 R^2 is independently − C ( = O ) N R 3 a R 3 b -C(=O)NR^{3a}R^{3b} or C 2 − C 6 C_2-C_6 alkoxycarbonyl.

5. A fungicidal composition comprising (a) a compound of Claim 1; and (b) component selected from the group consisting of surfactants, solid diluents and liquid diluents.

6. A method for controlling plant diseases caused by fungal plant comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Claim 1.

7. A method for controlling plant diseases caused by Basidiomycetes fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Claim 1.

8. A compound of Claim 4 wherein: R 1 is U-2 connected at its 2-position to L; and each R 3b is independently H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 2 -C 4 alkenyl or C 2 -C 4 haloalkenyl.

9. A compound of Claim 1 wherein: R 1 is U-12 connected at its 3-position to L; L is CH 2 ; and each R 2 R^2 is independently − C ( = O ) N R 3 a R 3 b -C(=O)NR^{3a}R^{3b} ; or C 1 − C 6 C_1-C_6 alkyl, C 2 − C 6 C_2-C_6 alkoxycarbonyl, C 3 − C 6 C_3-C_6 alkenyloxycarbonyl or C 3 -C 6 alkynyloxycarbonyl, each optionally substituted with up to 1 substituent selected from R 10 R^{10} ; R 3 a R^{3a} is H or C 1 C_1 - C 4 C_4 alkyl; R 3 b R^{3b} is H, C 1 C_1 - C 3 C_3 alkyl, C 1 C_1 - C 3 C_3 haloalkyl or C 2 C_2 - C 4 C_4 alkenyl.

10. A compound of Claim 1 that is: [Image disponible dans le document PDF, Image available in the PDF document] ٠11. A compound of Claim 1 that is: [Image disponible dans le document PDF, Image available in the PDF document]12. A compound of Claim 1 that is: [Image disponible dans le document PDF, Image available in the PDF document]