New bicyclic pyrazole derivatives

Abstract

The present invention covers bicyclic pyrazole compounds of general formula (I) : in which G, A, R¹, R², R³, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and / or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Description

New bicyclic Pyrazole derivatives The present invention covers new bicyclic pyrazole derivatives of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the control, treatment and / or prevention of diseases, in particular for the control, treatment and / or prevention of infections with helminths, more particularly of infections with gastro-intestinal and extra-intestinal nematodes, in animals and humans, formulations containing such compounds and methods for the control, treatment and / or prevention of infections with helminths, more particularly of infections with gastro-intestinal and extra-intestinal nematodes, in animals and humans as a sole agent or in combination with other active ingredients. BACKGROUND The occurrence of resistances against all commercial anthelmintics seems to be a growing problem in the area of veterinary medicine. The extensive utilisation of anthelmintics to manage the control of nematodes resulted in significant selection of highly resistant worm populations. Therefore, the spread of resistance against all anthelmintic drug classes threatens effective worm control in cattle, goats, sheep and horses. Furthermore, successful prevention of heartworm disease in dogs, which currently solely relies on the utilisation of macrocyclic lactones, is in danger as loss of efficacy for multiple macrocyclic lactones has been described for some regions of the United States of America - especially in those areas where the heartworm challenge for infection is high. Finally, experimental infection studies with Dirofilaria immitis larvae from suspected loss of efficacy field cases in the Lower Mississippi Delta provided in vivo confirmation of the existence of macrocyclic lactone resistance. Although resistance of human helminths against anthelmintics seems currently to be rare, the spread of anthelmintic resistance in the veterinary field as mentioned before needs to be considered in the treatment of human helminthosis as well. Persistent underdosed treatments against filariosis may lead to highly resistant genotypes and resistances have already been described for certain anthelmintics (e.g. praziquantel, benzimidazole and niclosamide). Therefore, resistance-breaking anthelmintics with new molecular modes of action are urgently required. It is an object of the present invention to provide compounds which can be used as anthelmintics in the medical, especially veterinary, field with a satisfactory or improved anthelmintic activity against a broad spectrum of helminths, particularly at relatively low dosages, for the control, treatment and / or prevention of infections with helminths in animals and humans, preferably without any adverse toxic effects to the treated organism. Certain pyrazolopyrimidine carboxamides are related to their activity increasing the efficacy of the endogenous ligand 3-hydroxybutyrateas as described in Journal of Medicinal Chemistry, 55, (7), 3563- 3567. Other pyrazolopyrimidine carboxamides are described as allosteric agonists for the high affinity nicotinic acid receptor GPR109A as in Bioorganic & Medicinal Chemistry Letters, 18, (18), 4948-4951. Furthermore, pyrazolopyrimidine carboxamides are known as protein kinase modulators (EP1918291), as active ingredients for treatment or prevention of skin dieseases (WO 2009041663) or as NAD(P)H oxidase inhibitors (WO 2003091256). A certain method for a library synthesis process of said compounds is described in Journal of Combinatorial Chemistry, 9, (3), 507-512. Sulfonylphenylpyrazole compounds are also known as COX-2 inhibitors (WO 2001 / 16138). Further imidazopyrazole coupler for the use in image formation methods in silver halide color photographic materials are known (JP05034880A). However, the state of the art does not describe the new bicyclic pyrazole derivatives of general formula (I) of the present invention as described and defined herein. It has now been found, and this constitutes the basis of the present invention, that the compounds of the present invention have surprising and advantageous properties. In particular, the compounds of the present invention have surprisingly been found to effectively interact with Slo-1 of nematodes. This interaction is characterized by achieving paralysis / inhibition in particular of gastro-intestinal nematodes, of free-living nematodes, and of filariae, for which data are given in the biological experimental section. Therefore the compounds of the present invention may be used as anthelmintics for the control, treatment and / or prevention of gastro-intestinal and extra-intestinal helminth infections, in particular gastro-intestinal and extra-intestinal infections with nematodes, including filariae. DESCRIPTION of the INVENTION In accordance with a first aspect, the present invention covers compounds of general formula (I): [Image disponible dans le document PDF, Image available in the PDF document] (I) in which: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1, 2, 3 or 4, R is selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl and - SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, O, S, and N-R<com:Sup>8< / com:Sup>, wherein at least one of X and Y is CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, or X, Y form together a ring member selected from the group consisting of -C(O)-O-, -C(O)-NR<com:Sup>8< / com:Sup>-, - <com:Math><semantics>S(O)−NR8<annotation encoding="application / x-tex">S(O)-NR^8< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SO2−NR8<annotation encoding="application / x-tex">-SO_2-NR^8< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−SO2−O<annotation encoding="application / x-tex">-SO_2-O< / annotation>< / semantics>< / com:Math>-, G is S, O, N-R<com:Sup>8< / com:Sup> <com:Math><semantics>𝑹1<annotation encoding="application / x-tex">\mathbf{R}^1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, cyano, -CHO, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>- alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub>-alkyl, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl, -NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, NH<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, (C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>N-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl-C(O)- having 1 to 5 halogen atoms, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, benzyloxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -SO<com:Sub>2< / com:Sub>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkyl, and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl),−N(C1−C4−alkyl)2,−S−C1−C4−alkyl,−S(O)−C1−C4−alkyl,−SO2−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−a<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl), -N(C_1-C_4-alkyl)_2, -S-C_1-C_4-alkyl, -S(O)-C_1-C_4-alkyl, -SO_2-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-a< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}^2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl or phenyl-C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkyl)2<annotation encoding="application / x-tex">alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> alkyl)(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>(O)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>02-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, - <com:Math><semantics>C(O)−NH2<annotation encoding="application / x-tex">C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl−C(O)−−<annotation encoding="application / x-tex">C_1-C_4-alkyl-C(O)--< / annotation>< / semantics>< / com:Math>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, - <com:Math><semantics>NH2<annotation encoding="application / x-tex">NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> cycloalkyl), -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−SO2−C1<annotation encoding="application / x-tex">-SO_2-C_1< / annotation>< / semantics>< / com:Math>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl, <com:Math><semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, halogen, -OH, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), - <com:Math><semantics>N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ5<annotation encoding="application / x-tex">\mathbb{R}^5< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, or R<com:Sup>4< / com:Sup> and R<com:Sup>5< / com:Sup> form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl and 3- to 6-membered heterocycloalkyl, <com:Math><semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ7<annotation encoding="application / x-tex">\mathbb{R}^7< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, or R<com:Sup>6< / com:Sup> and R<com:Sup>7< / com:Sup> form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl and 3- to 6-membered heterocycloalkyl, <com:Math><semantics>ℝ8<annotation encoding="application / x-tex">\mathbb{R}^8< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy, <com:Math><semantics>R9<annotation encoding="application / x-tex">R^9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, -OH, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(-C(O)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- <com:Math><semantics>alkyl<annotation encoding="application / x-tex">alkyl< / annotation>< / semantics>< / com:Math>)(-C(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-<com:Math><semantics>alkyl<annotation encoding="application / x-tex">alkyl< / annotation>< / semantics>< / com:Math>), C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-<com:Math><semantics>alkoxy<annotation encoding="application / x-tex">alkoxy< / annotation>< / semantics>< / com:Math>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-<com:Math><semantics>alkoxy<annotation encoding="application / x-tex">alkoxy< / annotation>< / semantics>< / com:Math>-C(O)-; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−NH−C(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-NH-C(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(−C(O)−C1−C4−alkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(-C(O)-C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C1−C4−alkyl<annotation encoding="application / x-tex">-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C1−C4−alkyl<annotation encoding="application / x-tex">-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>(C1−C4−alkoxy)2P(=O)<annotation encoding="application / x-tex">(C_1-C_4-alkoxy)_2P(=O)< / annotation>< / semantics>< / com:Math>-; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, benzo-C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; a monocyclic or a bicyclic heterocycle selected from the group of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>R11<annotation encoding="application / x-tex">R^{11}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S2<annotation encoding="application / x-tex">-S_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -C(O)-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)<annotation encoding="application / x-tex">-S(O)< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S2<annotation encoding="application / x-tex">-S_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹12<annotation encoding="application / x-tex">\mathbf{R}^{12}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S2<annotation encoding="application / x-tex">-S_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -C(O)-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, Q is selected from the group consisting of 6- or 10-membered aryl and 5- to 10-membered heteroaryl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, SF<com:Sub>5< / com:Sub>, cyano, -CHO, nitro, oxo, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-hydroxyalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkoxy, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>- C4-alkyl), -N(C1-C4-alkyl)2, -NH(C3-C6-cycloalkyl), -N(C1-C4-alkyl)(C3-C6-cycloalkyl), -NH- <com:Math><semantics>SO2−(C1−C4−alkyl)<annotation encoding="application / x-tex">SO_2-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(SO2−[C1−C4−alkyl])(C1−C4−alkyl)<annotation encoding="application / x-tex">-N(SO_2-[C_1-C_4-alkyl])(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(C1−C4−alkoxyimino)−C1−C4−alkyl<annotation encoding="application / x-tex">(C_1-C_4-alkoxyimino)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH<com:Sub>2< / com:Sub>-O-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl), -CH<com:Sub>2< / com:Sub>-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, methyl substituted with a 4- to 6- membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH<com:Sub>2< / com:Sub>-S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl), -CH<com:Sub>2< / com:Sub>-S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CONH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -NHCO(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, wherein when Y is O, S or N-R<com:Sup>8< / com:Sup>, none of R<com:Sup>4< / com:Sup>, R<com:Sup>5< / com:Sup>, R<com:Sup>6< / com:Sup> and R<com:Sup>7< / com:Sup> is -OH, and wherein when X is O, S or N- <com:Math><semantics>R8<annotation encoding="application / x-tex">R^8< / annotation>< / semantics>< / com:Math>, none of <com:Math><semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is -OH, and stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, and mixtures of same. DEFINITIONS The term "substituted" means that one or more hydrogen atoms on the designated atom or group are replaced with a selection from the indicated group, provided that the designated atom's normal valency under the existing circumstances is not exceeded. Combinations of substituents and / or variables are permissible. The term "optionally substituted" means that the number of substituents can be equal to or different from zero. Unless otherwise indicated, it is possible that optionally substituted groups are substituted with as many optional substituents as can be accommodated by replacing a hydrogen atom with a non- hydrogen substituent on any available carbon or nitrogen atom. Commonly, it is possible for the number of optional substituents, when present, to be 1, 2, 3, 4 or 5, in particular 1, 2 or 3. As used herein, the term "one or more", e.g. in the definition of the substituents of the compounds of general formula (I) of the present invention, means "1, 2, 3, 4 or 5, particularly 1, 2, 3 or 4, more particularly 1, 2 or 3, even more particularly 1 or 2". As used herein, an oxo substituent represents an oxygen atom, which is bound to a carbon atom or to a sulfur atom via a double bond. The term "ring substituent" means a substituent attached to an aromatic or nonaromatic ring which replaces an available hydrogen atom on the ring. Should a composite substituent be composed of more than one parts, e.g. (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)-, it is possible for the position of a given part to be at any suitable position of said composite substituent, i.e. the C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy part can be attached to any carbon atom of the C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl part of said (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)- group. A hyphen at the beginning or at the end of such a composite substituent indicates the point of attachment of said composite substituent to the rest of the molecule. Should a ring, comprising carbon atoms and optionally one or more heteroatoms, such as nitrogen, oxygen or sulfur atoms for example, be substituted with a substituent, it is possible for said substituent to be bound at any suitable position of said ring, be it bound to a suitable carbon atom and / or to a suitable heteroatom. As used herein, the position via which a respective substituent is connected to the rest of the molecule may in a drawn structure be depicted by a hash sign (#) or a dashed line in said substituent. The term "comprising" when used in the specification includes "consisting of". If within the present text any item is referred to as "as mentioned herein", it means that it may be mentioned anywhere in the present text. The terms as mentioned in the present text have the following meanings: The term "halogen atom" means a fluorine, chlorine, bromine or iodine atom, particularly a fluorine, chlorine or bromine atom. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub>-alkyl" means a linear or branched, saturated, monovalent hydrocarbon group having 1, 2, 3, 4, 5 or 6 carbon atoms. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" means a linear or branched, saturated, monovalent hydrocarbon group having 1, 2, 3, or 4 carbon atoms, e.g. a methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl or a tert-butyl group, or an isomer thereof. Particularly, said group has 1, 2 or 3 carbon atoms ("<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-alkyl"), e.g. a methyl, ethyl, n-propyl or isopropyl group. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-hydroxyalkyl" means a linear or branched, saturated, monovalent hydrocarbon group in which the term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" is defined supra, and in which 1 or 2 hydrogen atoms are replaced with a hydroxy group, e.g. a hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 1-hydroxypropyl, 1-hydroxypropan-2-yl, 2-hydroxypropan-2-yl, 2,3-dihydroxypropyl, 1,3-dihydroxypropan-2-yl, 3-hydroxy-2-methyl-propyl, 2-hydroxy-2- methyl-propyl, 1-hydroxy-2-methyl-propyl group. The term "-NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)" or "-N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>" means a linear or branched, saturated, monovalent group in which the term "<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl" is as defined supra, e.g. a methylamino, ethylamino, n- propylamino, isopropylamino, N,N-dimethylamino, N-methyl-N-ethylamino or N,N-diethylamino group. The term "-S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl", "-S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" or "-SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" means a linear or branched, saturated group in which the term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" is as defined supra, e.g. a methylsulfanyl, ethylsulfanyl, n-propylsulfanyl, isopropylsulfanyl, n-butylsulfanyl, sec-butylsulfanyl, isobutylsulfanyl or tert- butylsulfanyl group, a methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl, sec-butylsulfinyl, isobutylsulfinyl or tert-butylsulfinyl group, or a methylsulfonyl, ethylsulfonyl, n- propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, sec-butylsulfonyl, isobutylsulfonyl or tert- butylsulfonyl group. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl" means a linear or branched, saturated, monovalent hydrocarbon group in which the term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" is as defined supra, and in which one or more of the hydrogen atoms are replaced, identically or differently, with a halogen atom. Particularly, said halogen atom is a fluorine atom. More particularly, all said halogen atoms are fluorine atoms ("C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-fluoroalkyl"). Said C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl group is, for example, fluoromethyl, difluoromethyl, trifluoromethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 3,3,3-trifluoropropyl or 1,3-difluoropropan-2-yl. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy" means a linear or branched, saturated, monovalent group of formula <com:Math><semantics>(C1−C4−alkyl)−O7<annotation encoding="application / x-tex">(C_1-C_4-alkyl)-O_7< / annotation>< / semantics>< / com:Math>, in which the term "<com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>" is as defined supra, e.g. a methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec-butoxy, isobutoxy or tert-butoxy group, or an isomer thereof. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy" means a linear or branched, saturated, monovalent C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy group, as defined supra, in which one or more of the hydrogen atoms is replaced, identically or differently, with a halogen atom. Particularly, said halogen atom is a fluorine atom. Said C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy group is, for example, fluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy or pentafluoroethoxy. The term "C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl" means a linear or branched, monovalent hydrocarbon group, which contains one double bond, and which has 2, 3 or 4 carbon atoms. Said C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl group is, for example, an ethenyl (or "vinyl"), a prop-2-en-1-yl (or "allyl"), prop-1-en-1-yl, but-3-enyl, but-2-enyl, but-1-enyl, prop-1-en-2-yl (or "isopropenyl"), 2-methylprop-2-enyl, 1-methylprop-2-enyl, 2-methylprop-1-enyl or a 1-methylprop-1-enyl, group. Particularly, said group is allyl. The term "C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl" means a linear monovalent hydrocarbon group which contains one triple bond, and which contains 2, 3 or 4 carbon atoms. Said C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl group is, for example, an ethynyl, a prop-1-ynyl, prop-2-ynyl (or "propargyl"), but-1-ynyl, but-2-ynyl, but-3-ynyl or 1-methylprop-2-ynyl, group. Particularly, said alkynyl group is prop-1-ynyl or prop-2-ynyl. The term "C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl" means a saturated, monovalent, monocyclic hydrocarbon ring which contains 3, 4, 5 or 6 carbon atoms ("C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl"). Said C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl group is for example, a monocyclic hydrocarbon ring, e.g. a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group. The term "C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl" means a saturated, monovalent, monocyclic hydrocarbon ring in which the term "C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl" is as defined supra, and in which one or more of the hydrogen atoms are replaced, identically or differently, with a halogen atom. Particularly, said halogen atom is a fluorine or chlorine atom. Said C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl group is for example, a monocyclic hydrocarbon ring substituted with one or two fluorine or chlorine atoms, e.g. a 1-fluoro-cyclopropyl, 2-fluorocyclopropyl, 2,2-difluorocyclopropyl, 2,3-difluorocyclopropyl, 1-chlorocyclopropyl, 2-chlorocyclopropyl, 2,2- dichlorocyclopropyl, 2,3-dichlorocyclopropyl, 2-fluoro-2-chlorocyclopropyl and 2-fluoro-3- chlorocyclopropyl group. The term "-NH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl)" or "-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl)" means a linear or branched, saturated, monovalent group in which the term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl" and the term "C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl" each is as defined supra, e.g. a cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino, N- methyl-N-cyclopropylamino, N-ethyl-N-cyclopropylamino, N-methyl-N-cyclobutylamino, N-ethyl-N- cyclobutylamino, N-methyl-N-cyclopentylamino, N-ethyl-N-cyclopentylamino, N-methyl-N- cyclohexylamino, or N-ethyl-N-cyclohexylamino group. The term "benzo-C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl" means a monovalent, bicyclic hydrocarbon ring wherein a saturated, monovalent, monocyclic hydrocarbon ring which contains 5 or 6 carbon atoms ("C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl") is annelated to a phenyl ring. Said benzo-C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl group is for example, a bicyclic hydrocarbon ring, e.g. an indane (i.e. 2,3-dihydro-1H-indene) or tetraline (i.e. 1,2,3,4-tetrahydronaphthalene) group. The term "spirocycloalkyl" means a saturated, monovalent bicyclic hydrocarbon group in which the two rings share one common ring carbon atom, and wherein said bicyclic hydrocarbon group contains 5, 6, 7, 8, 9, 10 or 11 carbon atoms, it being possible for said spirocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms except the spiro carbon atom. Said spirocycloalkyl group is, for example, spiro[2.2]pentyl, spiro[2.3]hexyl, spiro[2.4]heptyl, spiro[2.5]octyl, spiro[2.6]nonyl, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[3.5]nonyl, spiro[3.6]decyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[4.6]undecyl or spiro[5.5]undecyl. The term "heterocycloalkyl" means a monocyclic or bicyclic, saturated or partially saturated heterocycle with 4, 5, 6, 7, 8, 9 or 10 ring atoms in total (a "4- to 10-membered heterocycloalkyl" group), particularly 4, 5 or 6 ring atoms (a "4- to 6-membered heterocycloalkyl" group), which contains one or two identical or different ring heteroatoms from the series N, O and S, it being possible for said heterocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms or, if present, a nitrogen atom. Said heterocycloalkyl group, without being limited thereto, can be a 4-membered ring, such as azetidinyl, oxetanyl or thietanyl, for example; or a 5-membered ring, such as tetrahydrofuranyl, 1,3- dioxolanyl, thiolanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, 1,1-dioxidothiolanyl, 1,2-oxazolidinyl, 1,3-oxazolidinyl, 1,3-thiazolidinyl or 1,2,4-triazolidinyl, for example; or a 6-membered ring, such as tetrahydropyranyl, tetrahydrothiopyranyl, piperidinyl, morpholinyl, dithianyl, thiomorpholinyl, piperazinyl, 1,3-dioxanyl, 1,4-dioxanyl or 1,2-oxazinanyl, for example; or a 7-membered ring, such as azepanyl, 1,4-diazepanyl or 1,4-oxazepanyl, for example; or a bicyclic 7-membered ring, such as 6-oxa- 3-azabicyclo[3.1.1]heptan, for example; or a bicyclic 8-membered ring, such as 5,6-dihydro-4H- furo[2,3-c]pyrrole or 8-oxa-3-azabicyclo[3.2.1]octan, for example; or a bicyclic 9-membered ring, such as octahydro-1H-pyrrolo[3,4-b]pyridine, 1,3-dihydro-isoindol, 2,3-dihydro-indol or 3,9-dioxa-7- azabicyclo[3.3.1]nonan, for example; or a bicyclic 10-membered ring, such as decahydroquinoline or 3,4-dihydroisoquinolin, for example. The term "heterospirocycloalkyl" means a bicyclic, saturated heterocycle with 6, 7, 8, 9, 10 or 11 ring atoms in total, in which the two rings share one common ring carbon atom, which "heterospirocycloalkyl" contains one or two identical or different ring heteroatoms from the series: N, O, S; it being possible for said heterospirocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms, except the spiro carbon atom, or, if present, a nitrogen atom. Said heterospirocycloalkyl group is, for example, azaspiro[2.3]hexyl, azaspiro[3.3]heptyl, oxaazaspiro[3.3]heptyl, thiaazaspiro[3.3]heptyl, oxaspiro[3.3]heptyl, oxazaspiro[5.3]nonyl, oxazaspiro[4.3]octyl, oxazaspiro[2.5]octyl, azaspiro[4.5]decyl, oxazaspiro[5.5]undecyl, diazaspiro[3.3]heptyl, thiazaspiro[3.3]heptyl, thiazaspiro[4.3]octyl, azaspiro[5.5]undecyl, or one of the further homologous scaffolds such as spiro[3.4]-, spiro[4.4]-, spiro[2.4]-, spiro[2.5]-, spiro[2.6]-, spiro[3.5]-, spiro[3.6]-, spiro[4.5]- and spiro[4.6]-. The term "6- or 10-membered aryl" means a monovalent, monocyclic or bicyclic aromatic ring having 6 or 10 carbon ring atoms, e.g. a phenyl or naphthyl group. The term "heteroaryl" means a monovalent, monocyclic, bicyclic or tricyclic aromatic ring having 5, 6, 9 or 10 ring atoms (a "5- to 10-membered heteroaryl" group), particularly 5 or 6 ring atoms (a "5- to 6- membered heteroaryl" group), which contains at least one ring heteroatom and optionally one, two or three further ring heteroatoms from the series: N, O and / or S, and which is bound via a ring carbon atom or optionally via a ring nitrogen atom (if allowed by valency). Said heteroaryl group can be a 5-membered heteroaryl group, such as, for example, thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl or tetrazolyl; or a 6-membered heteroaryl group, such as, for example, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl. The term "heterocyclyl" means a heterocycle selected from the group consisting of heterocycloalkyl and heteroaryl. Particularly, the term "4- to 6-membered heterocyclyl" means a heterocycle selected from the group consisting of 4- to 6-membered heterocycloalkyl and 5- to 6-membered heteroaryl. In general, and unless otherwise mentioned, the heteroaryl or heteroarylene groups include all possible isomeric forms thereof, e.g.: tautomers and positional isomers with respect to the point of linkage to the rest of the molecule. Thus, for some illustrative non-restricting examples, the term pyridinyl includes pyridin-2-yl, pyridin-3-yl and pyridin-4-yl; or the term thienyl includes thien-2-yl and thien-3-yl. The term "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>", as used in the present text, e.g. in the context of the definition of "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl", "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl", "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-hydroxyalkyl", "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy" or "C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy" means an alkyl group having a finite number of carbon atoms of 1 to 4, i.e. 1, 2, 3 or 4 carbon atoms. Further, as used herein, the term "<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>", as used in the present text, e.g. in the context of the definition of "C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl" or C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl, means a cycloalkyl group having a finite number of carbon atoms of 3 to 6, i.e. 3, 4, 5 or 6 carbon atoms. When a range of values is given, said range encompasses each value and sub-range within said range. For example: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] "<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>" encompasses <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>; "<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>" encompasses <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7<annotation encoding="application / x-tex">C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8<annotation encoding="application / x-tex">C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C8<annotation encoding="application / x-tex">C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C7<annotation encoding="application / x-tex">C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3−C6<annotation encoding="application / x-tex">C_3-C_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3−C5<annotation encoding="application / x-tex">C_3-C_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3−C4<annotation encoding="application / x-tex">C_3-C_4< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C10<annotation encoding="application / x-tex">C_4-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C9<annotation encoding="application / x-tex">C_4-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C8<annotation encoding="application / x-tex">C_4-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C7<annotation encoding="application / x-tex">C_4-C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C6<annotation encoding="application / x-tex">C_4-C_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C4−C5<annotation encoding="application / x-tex">C_4-C_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5−C10<annotation encoding="application / x-tex">C_5-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5−C9<annotation encoding="application / x-tex">C_5-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5−C8<annotation encoding="application / x-tex">C_5-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5−C7<annotation encoding="application / x-tex">C_5-C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C5−C6<annotation encoding="application / x-tex">C_5-C_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C10<annotation encoding="application / x-tex">C_6-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C9<annotation encoding="application / x-tex">C_6-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C8<annotation encoding="application / x-tex">C_6-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C7<annotation encoding="application / x-tex">C_6-C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C10<annotation encoding="application / x-tex">C_7-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C9<annotation encoding="application / x-tex">C_7-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C8<annotation encoding="application / x-tex">C_7-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8−C10<annotation encoding="application / x-tex">C_8-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8−C9<annotation encoding="application / x-tex">C_8-C_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] "<com:Math><semantics>C6−C10<annotation encoding="application / x-tex">C_6-C_{10}< / annotation>< / semantics>< / com:Math>" encompasses <com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7<annotation encoding="application / x-tex">C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8<annotation encoding="application / x-tex">C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C10<annotation encoding="application / x-tex">C_6-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C9<annotation encoding="application / x-tex">C_6-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C8<annotation encoding="application / x-tex">C_6-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C6−C7<annotation encoding="application / x-tex">C_6-C_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C10<annotation encoding="application / x-tex">C_7-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C9<annotation encoding="application / x-tex">C_7-C_9< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C7−C8<annotation encoding="application / x-tex">C_7-C_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8−C10<annotation encoding="application / x-tex">C_8-C_{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C8−C10<annotation encoding="application / x-tex">C_8-C_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>C9<annotation encoding="application / x-tex">C_9< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math>. As used herein, the term "leaving group" means an atom or a group of atoms that is displaced in a chemical reaction as stable species taking with it the bonding electrons. In particular, such a leaving group is selected from the group comprising: halide, in particular fluoride, chloride, bromide or iodide, (methylsulfonyl)oxy, [(trifluoromethyl)sulfonyl]oxy, [(nonafluorobutyl)sulfonyl]oxy, (phenylsulfonyl)oxy, [(4-methylphenyl)sulfonyl]oxy, [(4-bromophenyl)sulfonyl]oxy, [(4-nitrophenyl)sulfonyl]oxy, [(2-nitrophenyl)sulfonyl]oxy, [(4-isopropylphenyl)sulfonyl]oxy, [(2,4,6-triisopropylphenyl)sulfonyl]oxy, [(2,4,6-trimethylphenyl)sulfonyl]oxy, [(4-tert-butyl- phenyl)sulfonyl]oxy and [(4-methoxyphenyl)sulfonyl]oxy. An oxo substituent in the context of the invention means an oxygen atom, which is bound to a carbon atom via a double bond. It is possible for the compounds of general formula (I) to exist as isotopic variants. The invention therefore includes one or more isotopic variant(s) of the compounds of general formula (I), particularly deuterium-containing compounds of general formula (I). The term "Isotopic variant" of a compound or a reagent is defined as a compound exhibiting an unnatural proportion of one or more of the isotopes that constitute such a compound. The term "Isotopic variant of the compound of general formula (I)" is defined as a compound of general formula (I) exhibiting an unnatural proportion of one or more of the isotopes that constitute such a compound. The expression "unnatural proportion" means a proportion of such isotope which is higher than its natural abundance. The natural abundances of isotopes to be applied in this context are described in "Isotopic Compositions of the Elements 1997", Pure Appl. Chem., 70(1), 217-235, 1998. Examples of such isotopes include stable and radioactive isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, chlorine, bromine and iodine, such as <com:Sup>2< / com:Sup>H (deuterium), <com:Sup>3< / com:Sup>H (tritium), <com:Sup>11< / com:Sup>C, <com:Sup>13< / com:Sup>C, <com:Sup>14< / com:Sup>C, <com:Sup>15< / com:Sup>N, <com:Sup>17< / com:Sup>O, <com:Sup>18< / com:Sup>O, <com:Sup>32< / com:Sup>P, <com:Sup>33< / com:Sup>P, <com:Sup>33< / com:Sup>S, <com:Sup>34< / com:Sup>S, <com:Sup>35< / com:Sup>S, <com:Sup>36< / com:Sup>S, <com:Sup>18< / com:Sup>F, <com:Sup>36< / com:Sup>Cl, <com:Sup>82< / com:Sup>Br, <com:Sup>123< / com:Sup>I, <com:Sup>124< / com:Sup>I, <com:Sup>125< / com:Sup>I, <com:Sup>129< / com:Sup>I and <com:Sup>131< / com:Sup>I, respectively. With respect to the treatment and / or prevention of the disorders specified herein the isotopic variant(s) of the compounds of general formula (I) preferably contain deuterium ("deuterium-containing compounds of general formula (I)"). Isotopic variants of the compounds of general formula (I) in which one or more radioactive isotopes, such as <com:Sup>3< / com:Sup>H or <com:Sup>14< / com:Sup>C, are incorporated are useful e.g. in drug and / or substrate tissue distribution studies. These isotopes are particularly preferred for the ease of their incorporation and detectability. Positron emitting isotopes such as <com:Sup>18< / com:Sup>F or <com:Sup>11< / com:Sup>C may be incorporated into a compound of general formula (I). These isotopic variants of the compounds of general formula (I) are useful for in vivo imaging applications. Deuterium-containing and <com:Sup>13< / com:Sup>C-containing compounds of general formula (I) can be used in mass spectrometry analyses in the context of preclinical or clinical studies. Isotopic variants of the compounds of general formula (I) can generally be prepared by methods known to a person skilled in the art, such as those described in the schemes and / or examples herein, by substituting a reagent for an isotopic variant of said reagent, preferably for a deuterium-containing reagent. Depending on the desired sites of deuteration, in some cases deuterium from D<com:Sub>2< / com:Sub>O can be incorporated either directly into the compounds or into reagents that are useful for synthesizing such compounds. Deuterium gas is also a useful reagent for incorporating deuterium into molecules. Catalytic deuteration of olefinic bonds and acetylenic bonds is a rapid route for incorporation of deuterium. Metal catalysts (i.e. Pd, Pt, and Rh) in the presence of deuterium gas can be used to directly exchange deuterium for hydrogen in functional groups containing hydrocarbons. A variety of deuterated reagents and synthetic building blocks are commercially available from companies such as for example C / D / N Isotopes, Quebec, Canada; Cambridge Isotope Laboratories Inc., Andover, MA, USA; and CombiPhos Catalysts, Inc., Princeton, NJ, USA. The term "deuterium-containing compound of general formula (I)" is defined as a compound of general formula (I), in which one or more hydrogen atom(s) is / are replaced by one or more deuterium atom(s) and in which the abundance of deuterium at each deuterated position of the compound of general formula (I) is higher than the natural abundance of deuterium, which is about 0.015%. Particularly, in a deuterium-containing compound of general formula (I) the abundance of deuterium at each deuterated position of the compound of general formula (I) is higher than 10%, 20%, 30%, 40%, 50%, 60%, 70% or 80%, preferably higher than 90%, 95%, 96% or 97%, even more preferably higher than 98% or 99% at said position(s). It is understood that the abundance of deuterium at each deuterated position is independent of the abundance of deuterium at other deuterated position(s). The selective incorporation of one or more deuterium atom(s) into a compound of general formula (I) may alter the physicochemical properties (such as for example acidity [C. L. Perrin, et al., J. Am. Chem. Soc., 2007, 129, 4490], basicity [C. L. Perrin et al., J. Am. Chem. Soc., 2005, 127, 9641], lipophilicity [B. Testa et al., Int. J. Pharm., 1984, 19(3), 271]) and / or the metabolic profile of the molecule and may result in changes in the ratio of parent compound to metabolites or in the amounts of metabolites formed. Such changes may result in certain therapeutic advantages and hence may be preferred in some circumstances. Reduced rates of metabolism and metabolic switching, where the ratio of metabolites is changed, have been reported (A. E. Mutlib et al., Toxicol. Appl. Pharmacol., 2000, 169, 102). These changes in the exposure to parent drug and metabolites can have important consequences with respect to the pharmacodynamics, tolerability and efficacy of a deuterium-containing compound of general formula (I). In some cases deuterium substitution reduces or eliminates the formation of an undesired or toxic metabolite and enhances the formation of a desired metabolite (e.g. Nevirapine: A. M. Sharma et al., Chem. Res. Toxicol., 2013, 26, 410; Efavirenz: A. E. Mutlib et al., Toxicol. Appl. Pharmacol., 2000, 169, 102). In other cases the major effect of deuteration is to reduce the rate of systemic clearance. As a result, the biological half-life of the compound is increased. The potential clinical benefits would include the ability to maintain similar systemic exposure with decreased peak levels and increased trough levels. This could result in lower side effects and enhanced efficacy, depending on the particular compound's pharmacokinetic / pharmacodynamic relationship. ML-337 (C. J. Wenthur et al., J. Med. Chem., 2013, 56, 5208) and Odanacatib (K. Kassahun et al., WO2012 / 112363) are examples for this deuterium effect. Still other cases have been reported in which reduced rates of metabolism result in an increase in exposure of the drug without changing the rate of systemic clearance (e.g. Rofecoxib: F. Schneider et al., Arzneim. Forsch. / Drug. Res., 2006, 56, 295; Telaprevir: F. Maltais et al., J. Med. Chem., 2009, 52, 7993). Deuterated drugs showing this effect may have reduced dosing requirements (e.g. lower number of doses or lower dosage to achieve the desired effect) and / or may produce lower metabolite loads. A compound of general formula (I) may have multiple potential sites of attack for metabolism. To optimize the above-described effects on physicochemical properties and metabolic profile, deuterium- containing compounds of general formula (I) having a certain pattern of one or more deuterium- hydrogen exchange(s) can be selected. Particularly, the deuterium atom(s) of deuterium-containing compound(s) of general formula (I) is / are attached to a carbon atom and / or is / are located at those positions of the compound of general formula (I), which are sites of attack for metabolizing enzymes such as e.g. cytochrome <com:Math><semantics>P450<annotation encoding="application / x-tex">P_{450}< / annotation>< / semantics>< / com:Math>. Where the plural form of the word compounds, salts, polymorphs, hydrates, solvates and the like, is used herein, this is taken to mean also a single compound, salt, polymorph, isomer, hydrate, solvate or the like. By "stable compound or "stable structure" is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. The compounds of the present invention optionally contain one or more asymmetric centres, depending upon the location and nature of the various substituents desired. It is possible that one or more asymmetric carbon atoms are present in the (R) or (S) configuration, which can result in racemic mixtures in the case of a single asymmetric centre, and in diastereomeric mixtures in the case of multiple asymmetric centres. In certain instances, it is possible that asymmetry also be present due to restricted rotation about a given bond, for example, the central bond adjoining two substituted aromatic rings of the specified compounds. Preferred compounds are those which produce the more desirable biological activity. Separated, pure or partially purified isomers and stereoisomers or racemic or diastereomeric mixtures of the compounds of the present invention are also included within the scope of the present invention. The purification and the separation of such materials can be accomplished by standard techniques known in the art. Preferred isomers are those which produce the more desirable biological activity. These separated, pure or partially purified isomers or racemic mixtures of the compounds of this invention are also included within the scope of the present invention. The purification and the separation of such materials can be accomplished by standard techniques known in the art. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example, by the formation of diastereoisomeric salts using an optically active acid or base or formation of covalent diastereomers. Examples of appropriate acids are tartaric, diacetyltartaric, ditoluoyltartaric and camphorsulfonic acid. Mixtures of diastereoisomers can be separated into their individual diastereomers on the basis of their physical and / or chemical differences by methods known in the art, for example, by chromatography or fractional crystallisation. The optically active bases or acids are then liberated from the separated diastereomeric salts. A different process for separation of optical isomers involves the use of chiral chromatography (e.g., HPLC columns using a chiral phase), with or without conventional derivatisation, optimally chosen to maximise the separation of the enantiomers. Suitable HPLC columns using a chiral phase are commercially available, such as those manufactured by Daicel, e.g., Chiracel OD and Chiracel OJ, for example, among many others, which are all routinely selectable. Enzymatic separations, with or without derivatisation, are also useful. The optically active compounds of the present invention can likewise be obtained by chiral syntheses utilizing optically active starting materials. In order to distinguish different types of isomers from each other reference is made to IUPAC Rules Section E (Pure Appl Chem 45, 11-30, 1976). The present invention includes all possible stereoisomers of the compounds of the present invention as single stereoisomers, or as any mixture of said stereoisomers, e.g. (R)- or (S)- isomers, in any ratio. Isolation of a single stereoisomer, e.g. a single enantiomer or a single diastereomer, of a compound of the present invention is achieved by any suitable state of the art method, such as chromatography, especially chiral chromatography, for example. Further, it is possible for the compounds of the present invention to exist as tautomers. For example, any compound of the present invention which contains a substitution pattern resulting in <com:Math><semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>< / com:Math>-CH-moiety at the bicyclic pyrazole that has an increased C-H-acidity can exist as a tautomer, or even a mixture in any amount of the two tautomers. The present invention includes all possible tautomers of the compounds of the present invention as single tautomers, or as any mixture of said tautomers, in any ratio. Further, the compounds of the present invention can exist as N-oxides, which are defined in that at least one nitrogen of the compounds of the present invention is oxidised. The present invention includes all such possible N-oxides. The present invention also covers useful forms of the compounds of the present invention, such as metabolites, hydrates, solvates, prodrugs, salts, in particular pharmaceutically acceptable salts, and / or co-precipitates. The compounds of the present invention can exist as a hydrate, or as a solvate, wherein the compounds of the present invention contain polar solvents, in particular water, methanol or ethanol for example, as structural element of the crystal lattice of the compounds. It is possible for the amount of polar solvents, in particular water, to exist in a stoichiometric or non-stoichiometric ratio. In the case of stoichiometric solvates, e.g. a hydrate, hemi-, (semi-), mono-, sesqui-, di-, tri-, tetra-, penta- etc. solvates or hydrates, respectively, are possible. The present invention includes all such hydrates or solvates. Further, it is possible for the compounds of the present invention to exist in free form, e.g. as a free base, or as a free acid, or as a zwitterion, or to exist in the form of a salt. Said salt may be any salt, either an organic or inorganic addition salt, particularly any pharmaceutically acceptable organic or inorganic addition salt, which is customarily used in pharmacy, or which is used, for example, for isolating or purifying the compounds of the present invention. The term "pharmaceutically acceptable salt" refers to an inorganic or organic acid addition salt of a compound of the present invention. For example, see S. M. Berge, et al. "Pharmaceutical Salts," J. Pharm. Sci. 1977, 66, 1-19. A suitable pharmaceutically acceptable salt of the compounds of the present invention may be, for example, an acid-addition salt of a compound of the present invention bearing a nitrogen atom, in a chain or in a ring, for example, which is sufficiently basic, such as an acid-addition salt with an inorganic acid, or "mineral acid", such as hydrochloric, hydrobromic, hydroiodic, sulfuric, sulfamic, bisulfuric, phosphoric, or nitric acid, for example, or with an organic acid, such as formic, acetic, acetoacetic, pyruvic, trifluoroacetic, propionic, butyric, hexanoic, heptanoic, undecanoic, lauric, benzoic, salicylic, 2-(4-hydroxybenzoyl)-benzoic, camphoric, cinnamic, cyclopentanepropionic, digluconic, 3-hydroxy-2-naphthoic, nicotinic, pamoic, pectinic, 3-phenylpropionic, pivalic, 2- hydroxyethanesulfonic, itaconic, trifluoromethanesulfonic, dodecylsulfuric, ethanesulfonic, benzenesulfonic, para-toluenesulfonic, methanesulfonic, 2-naphthalenesulfonic, naphthalinedisulfonic, camphorsulfonic acid, citric, tartaric, stearic, lactic, oxalic, malonic, succinic, malic, adipic, alginic, maleic, fumaric, D-gluconic, mandelic, ascorbic, glucoheptanoic, glycerophosphoric, aspartic, sulfosalicylic, or thiocyanic acid, for example. Further, another suitably pharmaceutically acceptable salt of a compound of the present invention which is sufficiently acidic, is an alkali metal salt, for example a sodium or potassium salt, an alkaline earth metal salt, for example a calcium, magnesium or strontium salt, or an aluminium or a zinc salt, or an ammonium salt derived from ammonia or from an organic primary, secondary or tertiary amine having 1 to 20 carbon atoms, such as ethylamine, diethylamine, triethylamine, ethyldiisopropylamine, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, dimethylaminoethanol, diethylaminoethanol, tris(hydroxymethyl)aminomethane, procaine, dibenzylamine, <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math>- methylmorpholine, arginine, lysine, 1,2-ethylenediamine, N-methylpiperidine, N-methyl-glucamine, N,N-dimethyl-glucamine, N-ethyl-glucamine, 1,6-hexanediamine, glucosamine, sarcosine, serinol, 2- amino-1,3-propanediol, 3-amino-1,2-propanediol, 4-amino-1,2,3-butanetriol, or a salt with a quarternary ammonium ion having 1 to 20 carbon atoms, such as tetramethylammonium, tetraethylammonium, <com:Math><semantics>tetra(n−propyl)<annotation encoding="application / x-tex">tetra(n-propyl)< / annotation>< / semantics>< / com:Math>ammonium, <com:Math><semantics>tetra(n−butyl)<annotation encoding="application / x-tex">tetra(n-butyl)< / annotation>< / semantics>< / com:Math>ammonium, <com:Math><semantics>N−benzyl−N,N,N−trimethylammonium,cholineor<annotation encoding="application / x-tex">N-benzyl-N,N,N-trimethylammonium, choline or< / annotation>< / semantics>< / com:Math> benzalkonium. Those skilled in the art will further recognise that it is possible for acid addition salts of the claimed compounds to be prepared by reaction of the compounds with the appropriate inorganic or organic acid via any of a number of known methods. Alternatively, alkali and alkaline earth metal salts of acidic compounds of the present invention are prepared by reacting the compounds of the present invention with the appropriate base via a variety of known methods. The present invention includes all possible salts of the compounds of the present invention as single salts, or as any mixture of said salts, in any ratio. In the present text, in particular in the Experimental Section, for the synthesis of intermediates and of examples of the present invention, when a compound is mentioned as a salt form with the corresponding base or acid, the exact stoichiometric composition of said salt form, as obtained by the respective preparation and / or purification process, is, in most cases, unknown. Unless specified otherwise, suffixes to chemical names or structural formulae relating to salts, such as "hydrochloride", "trifluoroacetate", "sodium salt", or "x HCl", "x CF<com:Sub>3< / com:Sub>COOH", "x Na<com:Sup>+< / com:Sup>", for example, mean a salt form, the stoichiometry of which salt form not being specified. This applies analogously to cases in which synthesis intermediates or example compounds or salts thereof have been obtained, by the preparation and / or purification processes described, as solvates, such as hydrates, with (if defined) unknown stoichiometric composition. Furthermore, the present invention includes all possible crystalline forms, or polymorphs, of the compounds of the present invention, either as single polymorph, or as a mixture of more than one polymorph, in any ratio. Moreover, the present invention also includes prodrugs of the compounds according to the invention. The term "prodrugs" here designates compounds which themselves can be biologically active or inactive, but are converted (for example metabolically or hydrolytically) into compounds according to the invention during their residence time in the body. In accordance with a second embodiment of the first aspect, the present invention covers compounds of general formula (I), supra, in which: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1, 2, 3 or 4, R is selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl and - SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, O, S, and N-R<com:Sup>8< / com:Sup>, wherein at least one of X and Y is <com:Math><semantics>CR6R7<annotation encoding="application / x-tex">CR^6R^7< / annotation>< / semantics>< / com:Math>, or X, Y form together a ring member selected from the group consisting of -C(O)-O-, -C(O)-NR<com:Sup>8< / com:Sup>-, - <com:Math><semantics>S(O)−NR8<annotation encoding="application / x-tex">S(O)-NR^8< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SO2−NR8<annotation encoding="application / x-tex">-SO_2-NR^8< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−SO2−O<annotation encoding="application / x-tex">-SO_2-O< / annotation>< / semantics>< / com:Math>-, G is S, O, N-R<com:Sup>8< / com:Sup> <com:Math><semantics>𝑹1<annotation encoding="application / x-tex">\mathbf{R}^1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, cyano, -CHO, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>- alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub>-alkyl, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl, -NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, NH<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, (C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>N-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl-C(O)- having 1 to 5 halogen atoms, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, benzyloxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -SO<com:Sub>2< / com:Sub>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkyl, and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl),−N(C1−C4−alkyl)2,−S−C1−C4−alkyl,−S(O)−C1−C4−alkyl,−SO2−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−a<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl), -N(C_1-C_4-alkyl)_2, -S-C_1-C_4-alkyl, -S(O)-C_1-C_4-alkyl, -SO_2-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-a< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl),−N(C1−C4−alkyl)2,−S−C1−C4−alkyl,−S(O)−C1−C4−alkyl,−SO2−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−alkyl,−S−C1−C4−a<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl), -N(C_1-C_4-alkyl)_2, -S-C_1-C_4-alkyl, -S(O)-C_1-C_4-alkyl, -SO_2-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-alkyl, -S-C_1-C_4-a< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹2<annotation encoding="application / x-tex">\mathbf{R}^2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl or phenyl-C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkyl)2<annotation encoding="application / x-tex">alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> alkyl)(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>(O)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>02-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, - <com:Math><semantics>C(O)−NH2<annotation encoding="application / x-tex">C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl−C(O)<annotation encoding="application / x-tex">C_1-C_4-alkyl-C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, - <com:Math><semantics>NH2<annotation encoding="application / x-tex">NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> cycloalkyl), -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−SO2−C1<annotation encoding="application / x-tex">-SO_2-C_1< / annotation>< / semantics>< / com:Math>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and 4- to 10-membered heterocycloalkyl, <com:Math><semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, halogen, -OH, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), - <com:Math><semantics>N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ5<annotation encoding="application / x-tex">\mathbb{R}^5< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>𝑹7<annotation encoding="application / x-tex">\mathbf{R}^7< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ8<annotation encoding="application / x-tex">\mathbb{R}^8< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy, <com:Math><semantics>R9<annotation encoding="application / x-tex">R^9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R10<annotation encoding="application / x-tex">R^{10}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, -OH, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(-C(O)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkoxy; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> <com:Math><semantics>alkyl2<annotation encoding="application / x-tex">alkyl_{2}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH−C(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-NH-C(O)-C_{1}-C_{4}-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)−(−C(O)−C1−C4−alkyl)<annotation encoding="application / x-tex">-N(C_{1}-C_{4}-alkyl)-(-C(O)-C_{1}-C_{4}-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_{1}-C_{4}-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_{1}-C_{4}-alkyl< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, <com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -S-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>(C1−C4−alkoxy)2P(=O)<annotation encoding="application / x-tex">(C_1-C_4-alkoxy)_2P(=O)< / annotation>< / semantics>< / com:Math>-; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, benzo-C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>R11<annotation encoding="application / x-tex">R^{11}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -C(O)-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹12<annotation encoding="application / x-tex">\mathbf{R}^{12}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>NH2<annotation encoding="application / x-tex">NH_2< / annotation>< / semantics>< / com:Math>, -<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>NH(C1<annotation encoding="application / x-tex">NH(C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>N(C1<annotation encoding="application / x-tex">N(C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^{1}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^{2}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z3<annotation encoding="application / x-tex">Z^{3}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z4<annotation encoding="application / x-tex">Z^{4}< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>Z5<annotation encoding="application / x-tex">Z^{5}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, SF<com:Sub>5< / com:Sub>, cyano, -CHO, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -NH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NH-SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl), <com:Math><semantics>−N(SO2−[C1−C4−alkyl])(C1−C4−alkyl)<annotation encoding="application / x-tex">-N(SO_2-[C_1-C_4-alkyl])(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(C1−C4−alkoxyimino)−C1−C4−alkyl<annotation encoding="application / x-tex">(C_1-C_4-alkoxyimino)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, 4- to 6- membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH<com:Sub>2< / com:Sub>-O- (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH<com:Sub>2< / com:Sub>-S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -S- <com:Math><semantics>(C1−C4−alkyl)<annotation encoding="application / x-tex">(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−(C1−C4−alkyl)<annotation encoding="application / x-tex">-S(O)-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−(C1−C4−alkyl)<annotation encoding="application / x-tex">-SO_2-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−halogenoalkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-halogenoalkyl)< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>- (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CONH(C<com:Sub>3< / com:Sub>- C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -NHCO(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl) having 1 to 5 halogen atoms, or <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^2< / annotation>< / semantics>< / com:Math> form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine and oxo, and <com:Math><semantics>Z3<annotation encoding="application / x-tex">Z^3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z4<annotation encoding="application / x-tex">Z^4< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>Z5<annotation encoding="application / x-tex">Z^5< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, SF<com:Sub>5< / com:Sub>, cyano, CHO, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), - <com:Math><semantics>N(C1−C4−alkyl)2<annotation encoding="application / x-tex">N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH−SO2−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH-SO_2-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> <com:Math><semantics>(C1−C4−alkyl)<annotation encoding="application / x-tex">(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(SO2−[C1−C4−alkyl])(C1−C4−alkyl)<annotation encoding="application / x-tex">-N(SO_2-[C_1-C_4-alkyl])(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>(C1−C4−alkoxyimino)−C1−C4−alkyl<annotation encoding="application / x-tex">(C_1-C_4-alkoxyimino)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, -CH2-O- (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, methyl substituted with a 4- to 6-membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, -CH<com:Sub>2< / com:Sub>-S- <com:Math><semantics>(C1−C4−alkyl)<annotation encoding="application / x-tex">(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2−S(O)−(C1−C4−alkyl)<annotation encoding="application / x-tex">-CH_2-S(O)-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2−SO2−(C1−C4−alkyl)<annotation encoding="application / x-tex">-CH_2-SO_2-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−alkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−alkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−alkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math> <com:Math><semantics>S(O)−(C1−C4−alkyl)<annotation encoding="application / x-tex">S(O)-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−(C1−C4−alkyl)<annotation encoding="application / x-tex">-SO_2-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−halogenoalkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-halogenoalkyl)< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CONH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -NHCO(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl) having 1 to 5 halogen atoms, or <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z3<annotation encoding="application / x-tex">Z^3< / annotation>< / semantics>< / com:Math> form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two subsitutents selected from the group consisting of methyl, fluorine and oxo, and <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z4<annotation encoding="application / x-tex">Z^4< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>Z5<annotation encoding="application / x-tex">Z^5< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, SF<com:Sub>5< / com:Sub>, cyano, CHO, nitro, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH−SO2−(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH-SO_2-(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>< / com:Math> N(SO<com:Sub>2< / com:Sub>-[C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl])(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), (C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxyimino)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, -CH<com:Sub>2< / com:Sub>-O-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-NH(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>-N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, methyl substituted with a 4- to 6-membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl or cyano, -CH<com:Sub>2< / com:Sub>-S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CH<com:Sub>2< / com:Sub>- <com:Math><semantics>S(O)−(C1−C4−alkyl),−CH2−SO2−(C1−C4−alkyl),−S−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−S(O)−(C1−C<annotation encoding="application / x-tex">S(O)-(C_1-C_4-alkyl), -CH_2-SO_2-(C_1-C_4-alkyl), -S-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C< / annotation>< / semantics>< / com:Math> SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -S-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -CONH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -NHCO(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -NHCO(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q2) [Image disponible dans le document PDF, Image available in the PDF document] (Q2) in which: <com:Math><semantics>Z6,Z7,Z8 and Z9<annotation encoding="application / x-tex">Z^{6}, Z^{7}, Z^{8} \text{ and } Z^{9}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), or Q is a pyrimidine ring of the formula (Q3) [Image disponible dans le document PDF, Image available in the PDF document] (Q3) in which: Z<com:Sup>10< / com:Sup>, Z<com:Sup>11< / com:Sup> and Z<com:Sup>12< / com:Sup> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, or Q is a pyridine ring of the formula (Q4) [Image disponible dans le document PDF, Image available in the PDF document] (Q4) in which: Z<com:Sup>13< / com:Sup>, Z<com:Sup>14< / com:Sup>, Z<com:Sup>15< / com:Sup> and Z<com:Sup>16< / com:Sup> are independently selected from the group consisting of hydrogen halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-hydroxyalkyl, NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> cycloalkyl), -NH-CO-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, and monocyclic heterocycles selected from the group of 4- to 7-membered heterocycloalkyl or 5-membered heteroaryls having at least one nitrogen atom via which the heteroaryl ring is connected to the pyridine ring, each of which is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkyl)2<annotation encoding="application / x-tex">alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−halogenoalkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-halogenoalkyl)< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q5) [Image disponible dans le document PDF, Image available in the PDF document] (Q5) in which: <com:Math><semantics>Z17<annotation encoding="application / x-tex">Z^{17}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z18<annotation encoding="application / x-tex">Z^{18}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z19<annotation encoding="application / x-tex">Z^{19}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z20<annotation encoding="application / x-tex">Z^{20}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -NH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), or Q is a 5-membered aromatic heterocycle of the formula (Q6) [Image disponible dans le document PDF, Image available in the PDF document] (Q6) in which: T<com:Sup>1< / com:Sup> - T<com:Sup>4< / com:Sup> are independently selected from the group consisting of N, O, S, C-Z<com:Sup>21< / com:Sup> and N-Z<com:Sup>22< / com:Sup>, wherein not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is O, not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is S, not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is N-Z<com:Sup>22< / com:Sup>, and wherein each Z<com:Sup>21< / com:Sup> is independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, and each Z<com:Sup>22< / com:Sup> is independently selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, or 5 Q is a 5-membered aromatic heterocycle of the formula (Q7) [Image disponible dans le document PDF, Image available in the PDF document] (Q7) in which: U<com:Sup>1< / com:Sup> – U<com:Sup>4< / com:Sup> are independently selected from the group consisting of N and C-Z<com:Sup>23< / com:Sup>, wherein not more than three of <com:Math><semantics>U1−U4<annotation encoding="application / x-tex">U^1 - U^4< / annotation>< / semantics>< / com:Math> are N, and wherein each Z<com:Sup>23< / com:Sup> is independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, wherein when Y is O, S or N-R<com:Sup>8< / com:Sup>, none of R<com:Sup>4< / com:Sup>, R<com:Sup>5< / com:Sup>, R<com:Sup>6< / com:Sup> and R<com:Sup>7< / com:Sup> is -OH, and wherein when X is O, S or N-R<com:Sup>8< / com:Sup>, none of <com:Math><semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>< / com:Math> is -OH, and stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, and mixtures of same. In accordance with a third embodiment of the first aspect, the present invention covers compounds of general formula (I), supra, in which: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1, 2, 3 or 4, R is selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl and - SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, O, S, and N-R<com:Sup>8< / com:Sup>, wherein at least one of X and Y is CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, or X, Y form together a ring member selected from the group consisting of -C(O)-O-, -C(O)-NR<com:Sup>8< / com:Sup>-, - <com:Math><semantics>S(O)−NR8<annotation encoding="application / x-tex">S(O)-NR^8< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SO2−NR8<annotation encoding="application / x-tex">-SO_2-NR^8< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−SO2−O<annotation encoding="application / x-tex">-SO_2-O< / annotation>< / semantics>< / com:Math>-, G is S, O, N-R<com:Sup>8< / com:Sup> <com:Math><semantics>𝑹1<annotation encoding="application / x-tex">\mathbf{R}^1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, cyano, -CHO, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-halogenocycloalkyl having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>- alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub>-alkyl, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl, -NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, NH<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-NH-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, (C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>N-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl-C(O)- having 1 to 5 halogen atoms, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, benzyloxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -SO<com:Sub>2< / com:Sub>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkyl, and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>ℝ2<annotation encoding="application / x-tex">\mathbb{R}^2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, halogen, cyano, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), - <com:Math><semantics>C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-C(O)-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>−NR9R10<annotation encoding="application / x-tex">-NR^{9}R^{10}< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>−OR11<annotation encoding="application / x-tex">-OR^{11}< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>−SR12<annotation encoding="application / x-tex">-SR^{12}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)R12<annotation encoding="application / x-tex">-S(O)R^{12}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2R12<annotation encoding="application / x-tex">-SO_2R^{12}< / annotation>< / semantics>< / com:Math>; C<com:Sub>1< / com:Sub>-C<com:Sub>6< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl or phenyl-C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkyl)2<annotation encoding="application / x-tex">alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO<com:Sub>2< / com:Sub>, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> alkyl)(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>(<com:Math><semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>< / com:Math>)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>0-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, - <com:Math><semantics>C(O)−NH2<annotation encoding="application / x-tex">C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl−C(O)<annotation encoding="application / x-tex">C_1-C_4-alkyl-C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, - <com:Math><semantics>NH2<annotation encoding="application / x-tex">NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> cycloalkyl), -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−SO2−C1<annotation encoding="application / x-tex">-SO_2-C_1< / annotation>< / semantics>< / com:Math>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and 4- to 10-membered heterocycloalkyl, <com:Math><semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, halogen, -OH, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>-cycloalkyl), - <com:Math><semantics>N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ5<annotation encoding="application / x-tex">\mathbb{R}^5< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>𝑹7<annotation encoding="application / x-tex">\mathbf{R}^{7}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, -OH, fluorine, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, <com:Math><semantics>ℝ8<annotation encoding="application / x-tex">\mathbb{R}^8< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy, R<com:Sup>9< / com:Sup> and R<com:Sup>10< / com:Sup> are independently selected from the group consisting of hydrogen, -OH, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(-C(O)-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>- alkoxy; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−NH−C(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-NH-C(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)−(−C(O)−C1−C4−alkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)-(-C(O)-C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>(C1−C4−alkoxy)2P(=O)<annotation encoding="application / x-tex">(C_1-C_4-alkoxy)_2P(=O)< / annotation>< / semantics>< / com:Math>-; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, benzo-C<com:Sub>5< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹11<annotation encoding="application / x-tex">\mathbf{R}^{11}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S2<annotation encoding="application / x-tex">-S_2< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S1<annotation encoding="application / x-tex">-S_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>𝑹12<annotation encoding="application / x-tex">\mathbf{R}^{12}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen; C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, phenyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, <com:Math><semantics>−COOH<annotation encoding="application / x-tex">-COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4<annotation encoding="application / x-tex">C_1-C_4< / annotation>< / semantics>< / com:Math>-alkoxy-<com:Math><semantics>C(O)<annotation encoding="application / x-tex">C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−NH2<annotation encoding="application / x-tex">-C(O)-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C1−C4<annotation encoding="application / x-tex">-C(O)-NH(C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl), <com:Math><semantics>−C(O)−N(C1−C4−C4)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-C_4)< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkoxy−C(O)−,−C(O)−NH2,−C(O)−NH(C1−C4−alkyl),−C(O)−N(C1−C4−alkyl)2,C1−C4−alkyl,C1−C4−alkyl)2<annotation encoding="application / x-tex">alkoxy-C(O)-, -C(O)-NH_2, -C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math> halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- <com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>-alkyl, <com:Math><semantics>−S−C1−C4<annotation encoding="application / x-tex">-S-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms, <com:Math><semantics>−S(O)−C1−C4<annotation encoding="application / x-tex">-S(O)-C_1-C_4< / annotation>< / semantics>< / com:Math>-halogenoalkyl having 1 to 5 halogen atoms and <com:Math><semantics>−SO2−C1−C4<annotation encoding="application / x-tex">-SO_2-C_1-C_4< / annotation>< / semantics>< / com:Math>- halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>- cycloalkyl, <com:Math><semantics>−NH2<annotation encoding="application / x-tex">-NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_4-alkyl< / annotation>< / semantics>< / com:Math> C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)- <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, hydroxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, -S-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, - S(O)-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms and –SO<com:Sub>2< / com:Sub>-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z3<annotation encoding="application / x-tex">Z^3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z4<annotation encoding="application / x-tex">Z^4< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>Z5<annotation encoding="application / x-tex">Z^5< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkyl), <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -S- <com:Math><semantics>(C1−C4−alkyl),−S(O)−(C1−C4−alkyl),−SO2−(C1−C4−alkyl),or<annotation encoding="application / x-tex">(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -SO_2-(C_1-C_4-alkyl), or< / annotation>< / semantics>< / com:Math> <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^2< / annotation>< / semantics>< / com:Math> form, together with the carbon atoms that they are connected to, a 5- or 6-membered heterocycloalkyl, a 5-membered heteroaryl, or a 6-membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine and oxo, and Z<com:Sup>3< / com:Sup>, Z<com:Sup>4< / com:Sup>, and Z<com:Sup>5< / com:Sup> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, or <com:Math><semantics>Z2<annotation encoding="application / x-tex">Z^2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z3<annotation encoding="application / x-tex">Z^3< / annotation>< / semantics>< / com:Math> form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two subsitutents selected from the group consisting of methyl, fluorine and oxo, and <com:Math><semantics>Z1<annotation encoding="application / x-tex">Z^1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z4<annotation encoding="application / x-tex">Z^4< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>Z5<annotation encoding="application / x-tex">Z^5< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q2) [Image disponible dans le document PDF, Image available in the PDF document] (Q2) in which: <com:Math><semantics>Z6,Z7,Z8 and Z9<annotation encoding="application / x-tex">Z^{6}, Z^{7}, Z^{8} \text{ and } Z^{9}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -NH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), or Q is a pyrimidine ring of the formula (Q3) [Image disponible dans le document PDF, Image available in the PDF document] (Q3) in which: <com:Math><semantics>Z10<annotation encoding="application / x-tex">Z^{10}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Z11<annotation encoding="application / x-tex">Z^{11}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Z12<annotation encoding="application / x-tex">Z^{12}< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, or Q is a pyridine ring of the formula (Q4) [Image disponible dans le document PDF, Image available in the PDF document] (Q4) in which: Z<com:Sup>13< / com:Sup>, Z<com:Sup>14< / com:Sup>, Z<com:Sup>15< / com:Sup> and Z<com:Sup>16< / com:Sup> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-hydroxyalkyl, NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>NH(C1−C4−alkyl)<annotation encoding="application / x-tex">NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math> cycloalkyl), -NH-CO-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, and monocyclic heterocycles selected from the group of 4- to 7-membered heterocycloalkyl or 5-membered heteroaryls having at least one nitrogen atom via which the heteroaryl ring is connected to the pyridine ring, each of which is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- <com:Math><semantics>alkyl)2<annotation encoding="application / x-tex">alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−C1−C4−alkyl<annotation encoding="application / x-tex">-S-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)−C1−C4−alkyl<annotation encoding="application / x-tex">-S(O)-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2−C1−C4−alkyl<annotation encoding="application / x-tex">-SO_2-C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−(C1−C4−halogenoalkyl)<annotation encoding="application / x-tex">-S-(C_1-C_4-halogenoalkyl)< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, -S(O)-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, -SO<com:Sub>2< / com:Sub>-(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl) having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q5) [Image disponible dans le document PDF, Image available in the PDF document] (Q5) in which: Z<com:Sup>17< / com:Sup>, Z<com:Sup>18< / com:Sup>, Z<com:Sup>19< / com:Sup> and Z<com:Sup>20< / com:Sup> are independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkoxy having 1 to 5 halogen atoms, -NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), -N(C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl)<com:Sub>2< / com:Sub>, -NH(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), -N(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl)(C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl), or Q is a 5-membered aromatic heterocycle of the formula (Q6) [Image disponible dans le document PDF, Image available in the PDF document] (Q6) in which: T<com:Sup>1< / com:Sup> - T<com:Sup>4< / com:Sup> are independently selected from the group consisting of N, O, S, C-Z<com:Sup>21< / com:Sup> and N-Z<com:Sup>22< / com:Sup>, wherein not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is O, not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is S, not more than one of <com:Math><semantics>T1−T4<annotation encoding="application / x-tex">T^1 - T^4< / annotation>< / semantics>< / com:Math> is N-Z<com:Sup>22< / com:Sup>, and wherein each <com:Math><semantics>Z21<annotation encoding="application / x-tex">Z^{21}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, and each Z<com:Sup>22< / com:Sup> is independently selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl-C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>- alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, or Q is a 5-membered aromatic heterocycle of the formula (Q7) [Image disponible dans le document PDF, Image available in the PDF document] (Q7) in which: <com:Math><semantics>U1−U4<annotation encoding="application / x-tex">U^1 - U^4< / annotation>< / semantics>< / com:Math> are independently selected from the group consisting of N and C-<com:Math><semantics>Z23<annotation encoding="application / x-tex">Z^{23}< / annotation>< / semantics>< / com:Math>, wherein not more than three of <com:Math><semantics>U1−U4<annotation encoding="application / x-tex">U^1 - U^4< / annotation>< / semantics>< / com:Math> are N, and wherein each <com:Math><semantics>Z23<annotation encoding="application / x-tex">Z^{23}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of hydrogen, halogen, cyano, C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, wherein when Y is O, S or N-R<com:Sup>8< / com:Sup>, R<com:Sup>4< / com:Sup> is not -OH, and stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, and mixtures of same. In accordance with a fourth embodiment of the first aspect, the present invention covers compounds of general formula (I), supra, in which: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1 or 2, R is selected from the group consisting of hydrogen, halogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl and C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR<com:Sup>6< / com:Sup>R<com:Sup>7< / com:Sup>, O, S, and N-R<com:Sup>8< / com:Sup>, wherein at least one of X and Y is <com:Math><semantics>CR6R7<annotation encoding="application / x-tex">CR^6R^7< / annotation>< / semantics>< / com:Math>, G is S, O, N-R<com:Sup>8< / com:Sup> <com:Math><semantics>𝑹1<annotation encoding="application / x-tex">\mathbf{R}^1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl-C<com:Sub>1< / com:Sub>-C<com:Sub>3< / com:Sub>-alkyl, cyano-C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, <com:Math><semantics>ℝ2<annotation encoding="application / x-tex">\mathbb{R}^2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydrogen, halogen, cyano, -COOH, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, -C(O)-NH(C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl), - <com:Math><semantics>C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−NH(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-C(O)-NH(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>−NR9R10<annotation encoding="application / x-tex">-NR^{9}R^{10}< / annotation>< / semantics>< / com:Math>; <com:Math><semantics>−OR11<annotation encoding="application / x-tex">-OR^{11}< / annotation>< / semantics>< / com:Math>; [Image disponible dans le document PDF, Image available in the PDF document] C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkenyl, C<com:Sub>3< / com:Sub>-C<com:Sub>6< / com:Sub>-cycloalkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>4< / com:Sub>-alkynyl or phenyl-C<com:Sub>1< / com:Sub>- C<com:Sub>4< / com:Sub>-alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, cyano, C<com:Sub>1< / com:Sub>-C<com:Sub>4< / com:Sub>-alkoxy-C(O)-, -C(O)-NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>C(O)−NH(C1−C4−alkyl)<annotation encoding="application / x-tex">C(O)-NH(C_1-C_4-alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)−N(C1−C4−alkyl)2<annotation encoding="application / x-tex">-C(O)-N(C_1-C_4-alkyl)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−alkyl<annotation encoding="application / x-tex">C_1-C_4-alkyl< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−C4−halogenoalkyl<annotation encoding="application / x-tex">C_1-C_4-halogenoalkyl< / annotation>< / semantics>< / com:Math> having 1 to 5 halogen atoms, <com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkoxy, -NH<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl), -N(<com:Math><semantics>C1<annotation encoding="application / x-tex">C_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>-alkyl)<com:Sub>2< / com:Sub>, -NH(<com:Math><semantics>C3<annotation encoding="application / x-tex">C_3< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>- cycloalkyl), <com:Math><semantics>−N(C1−C4−alkyl)(C3−C6−cycloalkyl)<annotation encoding="application / x-tex...

Claims

1. A compound of general formula (I): [Image disponible dans le document PDF, Image available in the PDF document] (I) in which: 5 Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1, 2, 3 or 4, R is selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , -S-C 1 -C 4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl, -S(O)-C 1 -C 4 -halogenoalkyl and - SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR 6 R 7 , O, S, and N-R 8 , wherein at least one of X and Y is CR 6 R 7 , or X, Y form together a ring member selected from the group consisting of -C(O)-O-, -C(O)-NR 8 -, -S(O)- N R 8 NR^8 -, -SO 2 -NR 8 - and -SO 2 -O-, G is S, O, N-R 8 ℝ 1 \mathbb{R}^1 is selected from the group consisting of hydrogen, cyano, -CHO, -OH, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 - alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 - alkyl, -NH-C 1 -C 4 -alkyl, -N(C 1 -C 4 -alkyl) 2 , NH 2 -C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-NH-C 1 -C 4 -alkyl-, (C 1 - C 4 -alkyl) 2 N-C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)-, C 1 -C 4 -halogenoalkyl-C(O)- having 1 to 5 halogen atoms, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, benzyloxy- C ( O ) C(O) -, C 1 C_1 - C 4 C_4 -alkoxy- C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -SO 2 - C 1 C_1 - C 4 C_4 - alkyl, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 - C 4 C_4 -alkyl), − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 - C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 - C 4 -alkyl) 2 , -S-C 1 -C 4 -alkyl, -S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and -SO 2 -C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, halogen, cyano, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , -C(O)-NH(C 1 -C 4 -alkyl), - [Image disponible dans le document PDF, Image available in the PDF document] − N R 9 R 10 -NR^9R^{10} ; − O R 11 -OR^{11} ; [Image disponible dans le document PDF, Image available in the PDF document] C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl-C 1 -C 4 - alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -alkyl-C(O)-, C 1 -C 4 -alkoxy-C(O)-, − C ( O ) − N H 2 -C(O)-NH_2 , − C ( O ) − N H ( C 1 − C 4 − a l k y l ) -C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − a l k y l C_1-C_4-alkyl having 1 to 5 halogen atoms, C 1 C_1 - C 4 C_4 -alkoxy, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − S − C 1 − C 4 -S-C_1-C_4 -alkyl, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -alkyl, − S O 2 − C 1 -SO_2-C_1 - C 4 -alkyl, –S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, –S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 - C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), -N( C 1 C_1 - C 4 C_4 -alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 -alkyl, -SO 2 - C 1 C_1 - C 4 C_4 -alkyl, -S- C 1 C_1 - C 4 C_4 - halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 , C 1 − C 4 − a l k y l , C 1 − C 4 − a l k y l − C ( O ) − − , C 1 − C 4 − a l k y l ) 2 C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl-C(O)--, C_1-C_4-alkyl)_2 halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 - C 4 -alkyl-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, -NH 2 , -NH(C 1 - C 4 C_4 -alkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl) 2 , − N H ( C 3 − C 6 -NH(C_3-C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − S − C 1 − C 4 -S-C_1-C_4 -alkyl) alkyl, -S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, halogen, -OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 - cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 - alkoxy, C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), - N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , and − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl , R 4 R^4 is selected from the group consisting of hydrogen, -OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, R 5 R^5 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, or R 4 and R 5 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl, R 6 R^6 is selected from the group consisting of hydrogen, -OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, ℝ 7 \mathbb{R}^7 is selected from the group consisting of hydrogen, -OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, or R 6 and R 7 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl, ℝ 8 \mathbb{R}^8 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy, R 9 and R 10 are independently selected from the group consisting of hydrogen, -OH, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH(-C(O)- C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 - alkyl)(-C(O)-C 1 -C 4 -alkyl), C 1 C_1 -C 4 -alkoxy, C 1 C_1 -C 4 -alkoxy-C(O)-; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) - N H 2 NH_2 , − C ( O ) -C(O) - N H ( C 1 NH(C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) - N ( C 1 N(C_1 - C 4 C_4 -alkyl) 2 , − N H -NH - C ( O ) C(O) - C 1 C_1 - C 4 C_4 -alkyl, − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( − C ( O ) − C 1 − C 4 -C(O)-C_1-C_4 -alkyl), C 1 − C 4 C_1-C_4 -alkyl, C 1 − C 4 C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and (C 1 -C 4 - a l k o x y ) 2 P ( = O ) − ; alkoxy)_2P(=O)-; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)- C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, R 11 R^{11} is selected from the group consisting of − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 ; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), - C ( O ) C(O) -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S ( O ) − C 1 − C 4 S(O)-C_1-C_4 -alkyl, − S O 2 − C 1 − C 4 -SO_2-C_1-C_4 -alkyl, − S − C 1 − C 4 -S-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) -S(O) - C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, R 12 R^{12} is selected from the group consisting of hydrogen; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) -NH 2 , − C ( O ) -C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)- C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, Q is selected from the group consisting of 6- or 10-membered aryl and 5- to 10-membered heteroaryl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, SF 5 , cyano, -CHO, nitro, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 - alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 - alkyl), − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − N H − S O 2 − -NH-SO_2- ( C 1 − C 4 − a l k y l ) (C_1-C_4-alkyl) , − N ( S O 2 − [ C 1 − C 4 − a l k y l ] ) ( C 1 − C 4 − a l k y l ) -N(SO_2-[C_1-C_4-alkyl])(C_1-C_4-alkyl) , ( C 1 − C 4 − a l k o x y i m i n o ) − C 1 − C 4 − a l k y l (C_1-C_4-alkoxyimino)-C_1-C_4-alkyl , 4- to 6- membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH 2 -O-(C 1 -C 4 -alkyl), -CH 2 - NH(C 1 -C 4 -alkyl), -CH 2 -N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH 2 -S-(C 1 -C 4 -alkyl), -CH 2 -S(O)-(C 1 -C 4 -alkyl), - C H 2 − S O 2 − ( C 1 − C 4 − a l k y l ) CH_2-SO_2-(C_1-C_4-alkyl) , − S − ( C 1 − C 4 − a l k y l ) -S-(C_1-C_4-alkyl) , − S ( O ) − ( C 1 − C 4 − a l k y l ) -S(O)-(C_1-C_4-alkyl) , − S O 2 − ( C 1 − C 4 − a l k y l ) -SO_2-(C_1-C_4-alkyl) , − S − ( C 1 − C 4 − a l k y l ) -S-(C_1-C_4-alkyl) halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -SO 2 -(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C 1 -C 4 - alkyl), -CONH(C3-C6-cycloalkyl), -NHCO(C1-C4-alkyl), -NHCO(C3-C6-cycloalkyl), and - NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, wherein when Y is O, S or N-R 8 , none of R 4 , R 5 , R 6 and R 7 is -OH, and wherein when X is O, S or N-R 8 , none of R 6 R^6 and R 7 R^7 is -OH, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

2. The compound according to claim 1, wherein: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0, 1, 2, 3 or 4, R is selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl, -S(O)-C 1 -C 4 -halogenoalkyl and - SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR 6 R 7 , O, S, and N-R 8 , wherein at least one of X and Y is CR 6 R 7 , or X, Y form together a ring member selected from the group consisting of -C(O)-O-, -C(O)-NR 8 -, -S(O)- N R 8 NR^8 -, − S O 2 -SO_2 - N R 8 NR^8 - and − S O 2 -SO_2 - O O -, G is S, O, or N − R 8 N-R^8 , ℝ 1 \mathbb{R}^1 is selected from the group consisting of hydrogen, cyano, -CHO, -OH, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 - alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 - alkyl, -NH- C 1 C_1 - C 4 C_4 -alkyl, -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , NH 2 - C 1 C_1 - C 4 C_4 -alkyl-, C 1 C_1 - C 4 C_4 -alkyl-NH- C 1 C_1 - C 4 C_4 -alkyl-, ( C 1 C_1 - C 4 -alkyl) 2 N-C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)-, C 1 -C 4 -halogenoalkyl-C(O)- having 1 to 5 halogen atoms, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, benzyloxy- C ( O ) C(O) -, C 1 C_1 - C 4 C_4 -alkoxy- C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -SO 2 - C 1 C_1 - C 4 C_4 - alkyl, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 - C 4 C_4 -alkyl), − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 - C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 - C 4 -alkyl) 2 , -S-C 1 -C 4 -alkyl, -S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and − S O 2 − C 1 − C 4 -SO_2-C_1-C_4 - halogenoalkyl having 1 to 5 halogen atoms, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, halogen, cyano, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , -C(O)-NH(C 1 -C 4 -alkyl), - C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 C(O)-N(C_1-C_4-alkyl)_2 , − C ( O ) − N H ( C 3 − C 6 − c y c l o a l k y l ) -C(O)-NH(C_3-C_6-cycloalkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -C(O)-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) ; − N R 9 R 10 -NR^{9}R^{10} ; − O R 11 -OR^{11} ; [Image disponible dans le document PDF, Image available in the PDF document] C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl-C 1 -C 4 - alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -alkyl-C(O)-, C 1 -C 4 -alkoxy-C(O)-, − C ( O ) − N H 2 -C(O)-NH_2 , − C ( O ) − N H ( C 1 − C 4 − a l k y l ) -C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − a l k y l C_1-C_4-alkyl having 1 to 5 halogen atoms, C 1 C_1 - C 4 C_4 -alkoxy, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − S − C 1 − C 4 -S-C_1-C_4 -alkyl, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -alkyl, − S O 2 − C 1 -SO_2-C_1 - C 4 -alkyl, –S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, –S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 - C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), -N( C 1 C_1 - C 4 C_4 -alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 -alkyl, -SO 2 - C 1 C_1 - C 4 C_4 -alkyl, -S- C 1 C_1 - C 4 C_4 - halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 , C 1 − C 4 − a l k y l , C 1 − C 4 − a l k y l − C ( O ) 4 , C 1 − C 4 − a l k y l 6 C(O)-NH(C_1-C_4-alkyl), -C(O)-N(C_1-C_4-alkyl)_2, C_1-C_4-alkyl, C_1-C_4-alkyl-C(O)_4, C_1-C_4-alkyl_6 halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 - C 4 -alkyl-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, -NH 2 , -NH(C 1 - C 4 C_4 -alkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl) 2 , − N H ( C 3 − C 6 -NH(C_3-C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − S − C 1 − C 4 -S-C_1-C_4 - alkyl, -S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, halogen, -OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 - cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 - alkoxy, C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), - N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , and − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl , R 4 R^4 is selected from the group consisting of hydrogen, -OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, R 5 R^5 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, R 6 R^6 is selected from the group consisting of hydrogen, -OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, ℝ 7 \mathbb{R}^7 is selected from the group consisting of hydrogen, -OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, ℝ 8 \mathbb{R}^8 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 C_1 - C 4 C_4 -alkoxy, R 9 R^9 and R 10 R^{10} are independently selected from the group consisting of hydrogen, − O H -OH , − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( − C ( O ) − C 1 − C 4 − a l k y l ) -NH(-C(O)-C_1-C_4-alkyl) , − C 1 − C 4 − a l k y l ) 2 -C_1-C_4-alkyl)_2 alkoxy; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) - N H 2 NH_2 , − C ( O ) -C(O) - N H ( C 1 NH(C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) - N ( C 1 N(C_1 - C 4 C_4 -alkyl) 2 , − N H -NH - C ( O ) C(O) - C 1 C_1 - C 4 C_4 -alkyl, − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)- ( − C ( O ) − C 1 − C 4 (-C(O)-C_1-C_4 -alkyl), C 1 − C 4 C_1-C_4 -alkyl, C 1 − C 4 C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and (C 1 -C 4 - a l k o x y ) 2 P ( = O ) alkoxy)_2P(=O) -; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)- C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, R 11 R^{11} is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) -NH 2 , − C ( O ) -C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , -S-C 1 -C 4 -alkyl, - S ( O ) − C 1 − C 4 S(O)-C_1-C_4 -alkyl, − S O 2 − C 1 − C 4 -SO_2-C_1-C_4 -alkyl, − S − C 1 − C 4 -S-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) -S(O) - C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, R 12 R^{12} is selected from the group consisting of hydrogen; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) -NH 2 , − C ( O ) -C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, - S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)- C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , - C ( O ) − N H ( C 1 − C 4 − a l k y l ) C(O)-NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 C_3 - C 6 C_6 -cycloalkyl, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -S- C 1 C_1 - C 4 C_4 -alkyl, -S(O)- C 1 C_1 - C 4 C_4 - alkyl, -SO 2 -C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, - C ( O ) C(O) -NH 2 , - C ( O ) C(O) -NH( C 1 C_1 - C 4 C_4 -alkyl), -C(O)-N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: Z 1 Z^{1} , Z 2 Z^{2} , Z 3 Z^{3} , Z 4 Z^{4} , and Z 5 Z^{5} are independently selected from the group consisting of hydrogen, halogen, SF 5 , cyano, -CHO, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 - halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , -NH(C 3 - C 6 C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − N H − S O 2 − ( C 1 − C 4 -NH-SO_2-(C_1-C_4 -alkyl), − N ( S O 2 − [ C 1 − C 4 ] ) -N(SO_2-[C_1-C_4]) C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH 2 -O-(C 1 -C 4 -alkyl), -CH 2 -NH(C 1 -C 4 - alkyl), -CH 2 -N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -CH 2 -S-(C 1 -C 4 -alkyl), -CH 2 - S(O)-(C 1 -C 4 -alkyl), -CH 2 -SO 2 -(C 1 -C 4 -alkyl), -S-(C 1 -C 4 -alkyl), -S(O)-(C 1 -C 4 -alkyl), -SO 2 - ( C 1 − C 4 − a l k y l ) (C_1-C_4-alkyl) , − S − ( C 1 − C 4 − h a l o g e n o a l k y l ) -S-(C_1-C_4-halogenoalkyl) having 1 to 5 halogen atoms, − S ( O ) − ( C 1 − C 4 − a l k y l ) -S(O)-(C_1-C_4-alkyl) halogenoalkyl) having 1 to 5 halogen atoms, -SO 2 -(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, − C O N H ( C 1 − C 4 − a l k y l ) -CONH(C_1-C_4-alkyl) , − C O N H ( C 3 − C 6 − c y c l o a l k y l ) -CONH(C_3-C_6-cycloalkyl) , − N H C O ( C 1 − C 4 − a l k y l ) -NHCO(C_1-C_4-alkyl) , − - NHCO(C 3 -C 6 -cycloalkyl), and -NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or Z 1 Z^1 and Z 2 Z^2 form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine and oxo, and Z 3 , Z 4 , and Z 5 are independently selected from the group consisting of hydrogen, halogen, SF 5 , cyano, CHO, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 - alkoxy-C(O)-, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), - N ( C 1 − C 4 − a l k y l ) 2 N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − N H − S O 2 − -NH-SO_2- ( C 1 − C 4 − a l k y l ) (C_1-C_4-alkyl) , − N ( S O 2 − [ C 1 − C 4 − a l k y l ] ) ( C 1 − C 4 − a l k y l ) -N(SO_2-[C_1-C_4-alkyl])(C_1-C_4-alkyl) , ( C 1 − C 4 − a l k o x y i m i n o ) − C 1 − C 4 − a l k y l (C_1-C_4-alkoxyimino)-C_1-C_4-alkyl , 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl, and cyano, -CH 2 -O-(C 1 -C 4 - alkyl), -CH 2 -NH(C 1 -C 4 -alkyl), -CH 2 -N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6- membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl, and cyano, -CH 2 -S-(C 1 -C 4 -alkyl), - C H 2 − S ( O ) − ( C 1 − C 4 − a l k y l ) , − C H 2 − S O 2 − ( C 1 − C 4 − a l k y l ) , − S − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( C 1 − C 4 − a l k y l ) , − S ( O ) − ( CH_2-S(O)-(C_1-C_4-alkyl), -CH_2-SO_2-(C_1-C_4-alkyl), -S-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-(C_1-C_4-alkyl), -S(O)-( SO 2 -(C 1 -C 4 -alkyl), -S-(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C 1 -C 4 - halogenoalkyl) having 1 to 5 halogen atoms, -SO 2 -(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C 1 -C 4 -alkyl), -CONH(C 3 -C 6 -cycloalkyl), -NHCO(C 1 -C 4 -alkyl), - NHCO( C 3 C_3 - C 6 C_6 -cycloalkyl), and -NHCO( C 1 C_1 - C 4 C_4 -halogenoalkyl) having 1 to 5 halogen atoms, or Z 2 Z^2 and Z 3 Z^3 form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine and oxo, and Z 1 Z^1 , Z 4 Z^4 , and Z 5 Z^5 are independently selected from the group consisting of hydrogen, halogen, SF 5 , cyano, CHO, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkoxy, cyano-C 1 -C 4 -alkoxy, C 1 -C 4 - halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , -NH(C 3 - C 6 C_6 -cycloalkyl), − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)( C 3 − C 6 C_3-C_6 -cycloalkyl), − N H − S O 2 − ( C 1 − C 4 -NH-SO_2-(C_1-C_4 -alkyl), − N ( S O 2 − [ C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C 1 − C 4 ] − ( C -N(SO_2-[C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C_1-C_4]-(C C 4 C_4 -alkyl])( C 1 C_1 - C 4 C_4 -alkyl), (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, 4- to 6-membered heterocycloalkyl which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl, and cyano, -CH 2 -O-(C 1 -C 4 -alkyl), -CH 2 -NH(C 1 -C 4 - alkyl), -CH 2 -N(C 1 -C 4 -alkyl) 2 , methyl substituted with a 4- to 6-membered heterocycloalkyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, methyl, and cyano, -CH 2 -S-(C 1 -C 4 -alkyl), -CH 2 -S(O)-(C 1 -C 4 -alkyl), − C H 2 − S O 2 − ( C 1 − C 4 − a l k y l ) -CH_2-SO_2-(C_1-C_4-alkyl) , − S − ( C 1 − C 4 − a l k y l ) -S-(C_1-C_4-alkyl) , − S ( O ) − ( C 1 − C 4 − a l k y l ) -S(O)-(C_1-C_4-alkyl) , − S O 2 − ( C 1 − C 4 − a l k y l ) -SO_2-(C_1-C_4-alkyl) , − S − ( C 1 − C 4 − a l k y l ) -S-(C_1-C_4-alkyl) (C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -SO 2 -(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -CONH(C 1 - C 4 -alkyl), -CONH(C 3 -C 6 -cycloalkyl), -NHCO(C 1 -C 4 -alkyl), -NHCO(C 3 -C 6 -cycloalkyl), and -NHCO(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q2) [Image disponible dans le document PDF, Image available in the PDF document] (Q2) in which: Z 6 , Z 7 , Z 8 and Z 9 Z^{6}, Z^{7}, Z^{8} \text{ and } Z^{9} are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 - C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , - NH(C 3 -C 6 -cycloalkyl), and -N(C 1 -C 4 -alkyl)(C 3 -C 6 -cycloalkyl), or Q is a pyrimidine ring of the formula (Q3) [Image disponible dans le document PDF, Image available in the PDF document] (Q3) in which: Z 10 Z^{10} , Z 11 Z^{11} and Z 12 Z^{12} are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 - C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , - N H ( C 3 − C 6 − c y c l o a l k y l ) NH(C_3-C_6-cycloalkyl) , and − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , or Q is a pyridine ring of the formula (Q4) - 145 - [Image disponible dans le document PDF, Image available in the PDF document] (Q4) in which: Z 13 Z^{13} , Z 14 Z^{14} , Z 15 Z^{15} and Z 16 Z^{16} are independently selected from the group consisting of hydrogen halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 - C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -hydroxyalkyl, NH 2 , -NH(C 1 -C 4 - alkyl), − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − N H − -NH- CO-C 1 -C 4 -alkyl, and monocyclic heterocycles selected from the group consisting of 4- to 7-membered heterocycloalkyl or 5-membered heteroaryls having at least one nitrogen atom via which the heteroaryl ring is connected to the pyridine ring, each of which is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, -OH, oxo, thiono, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , -SO 2 -C 1 -C 4 -alkyl, -S-(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, -S(O)-(C 1 -C 4 - halogenoalkyl) having 1 to 5 halogen atoms, and -SO 2 -(C 1 -C 4 -halogenoalkyl) having 1 to 5 halogen atoms, or Q is a pyridine ring of the formula (Q5) [Image disponible dans le document PDF, Image available in the PDF document] (Q5) in which: Z 17 Z^{17} , Z 18 Z^{18} , Z 19 Z^{19} and Z 20 Z^{20} are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 - C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 -alkyl) 2 , - N H ( C 3 − C 6 − c y c l o a l k y l ) NH(C_3-C_6-cycloalkyl) , and − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , or Q is a 5-membered aromatic heterocycle of the formula (Q6) [Image disponible dans le document PDF, Image available in the PDF document] (Q6) in which: T 1 − T 4 T^1 - T^4 are independently selected from the group consisting of N, O, S, C- Z 21 Z^{21} and N- Z 22 Z^{22} , wherein not more than one of T 1 − T 4 T^1 - T^4 is O, not more than one of T 1 − T 4 T^1 - T^4 is S, not more than one of T 1 − T 4 T^1 - T^4 is N-Z 22 , and wherein each Z 21 Z^{21} is independently selected from the group consisting of hydrogen, halogen, cyano, C 1 - C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 - halogenoalkoxy having 1 to 5 halogen atoms, and each Z 22 Z^{22} is independently selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C 3 -C 6 -cycloalkyl, and C 1 -C 4 - alkoxy-C 1 -C 4 -alkyl, or Q is a 5-membered aromatic heterocycle of the formula (Q7) [Image disponible dans le document PDF, Image available in the PDF document] (Q7) in which: U 1 – U 4 are independently selected from the group consisting of N and C-Z 23 , wherein not more than three of U 1 − U 4 U^1 - U^4 are N, and wherein each Z 23 Z^{23} is independently selected from the group consisting of hydrogen, halogen, cyano, C 1 - C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 - halogenoalkoxy having 1 to 5 halogen atoms, wherein when Y is O, S or N-R 8 , none of R 4 , R 5 , R 6 and R 7 is -OH, and wherein when X is O, S or N-R 8 , none of R 6 R^6 and R 7 R^7 is -OH, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

3. The compound according to claim 1 or 2, wherein: A is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 5 0 is 0, 1 or 2, R is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, cyano, and C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, X, Y are independently selected from the group consisting of CR 6 R 7 , O, S, and N-R 8 , wherein at least one of X and Y is C R 6 R 7 CR^6R^7 , G is S, O, N-R 8 ℝ 1 \mathbb{R}^1 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, and cyano-C 1 -C 4 -alkyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, halogen, cyano, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , -C(O)-NH(C 1 -C 4 -alkyl), - C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 C(O)-N(C_1-C_4-alkyl)_2 , − C ( O ) − N H ( C 3 − C 6 − c y c l o a l k y l ) -C(O)-NH(C_3-C_6-cycloalkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) -C(O)-N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) ; − N R 9 R 10 -NR^{9}R^{10} ; − O R 11 -OR^{11} ; − S R 12 -SR^{12} , − S ( O ) R 12 -S(O)R^{12} , − S O 2 R 12 -SO_2R^{12} ; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl-C 1 -C 4 - alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, -OH, cyano, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , -C(O)- N H ( C 1 − C 4 − a l k y l ) NH(C_1-C_4-alkyl) , − C ( O ) − N ( C 1 − C 4 − a l k y l ) 2 -C(O)-N(C_1-C_4-alkyl)_2 , C 1 − C 4 − a l k y l C_1-C_4-alkyl , C 1 − C 4 − h a l o g e n o a l k y l C_1-C_4-halogenoalkyl having 1 to 5 halogen atoms, C 1 C_1 - C 4 C_4 -alkoxy, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), -N( C 1 C_1 - C 4 C_4 -alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S (O)- C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - C 4 C_4 -alkyl, − S -S - C 1 C_1 - halogenoalkyl having 1 to 5 halogen atoms, − S ( O ) − C 1 − C 4 -S(O)-C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, and –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, -OH, oxo, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , -C(O)-NH(C 1 - C4-alkyl), -C(O)-N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-alkyl-C(O)-, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-, C 1 -C 4 - halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, -NH 2 , -NH(C 1 -C 4 -alkyl), -N(C 1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), -N( C 1 C_1 - C 4 C_4 -alkyl)( C 3 C_3 - C 6 C_6 -cycloalkyl), and 4- to 10-membered heterocycloalkyl, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, halogen, -OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 - cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 - alkoxy, C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), - N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl) , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , and − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl , R 4 R^4 is selected from the group consisting of hydrogen, -OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, R 5 R^5 is hydrogen, R 6 R^6 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl, ℝ 7 \mathbb{R}^7 is selected from the group consisting of hydrogen and C 1 C_1 - C 4 C_4 -alkyl, ℝ 8 \mathbb{R}^8 is selected from the group consisting of hydrogen and C 1 C_1 - C 4 C_4 -alkyl, R 9 and R 10 are independently selected from the group consisting of hydrogen, − N H ( − C ( O ) − C 1 − C 4 − a l k y l ) -NH(-C(O)-C_1-C_4-alkyl) , C 1 − C 4 − a l k o x y C_1-C_4-alkoxy ; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, -COOH, C 1 C_1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) - N H 2 NH_2 , − C ( O ) -C(O) - N H ( C 1 NH(C_1 - C 4 C_4 -alkyl), − C ( O ) -C(O) - N ( C 1 N(C_1 - C 4 C_4 -alkyl) 2 , − N H -NH - C ( O ) C(O) - C 1 C_1 - C 4 C_4 -alkyl, − N ( C 1 − C 4 -N(C_1-C_4 -alkyl)- ( − C ( O ) − C 1 − C 4 (-C(O)-C_1-C_4 -alkyl), C 1 − C 4 C_1-C_4 -alkyl, C 1 − C 4 C_1-C_4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 - cycloalkyl, − N H 2 -NH_2 , − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − S − C 1 − C 4 − a l k y l -S-C_1-C_4-alkyl , − S ( O ) − C 1 − C 4 − a l k y l -S(O)-C_1-C_4-alkyl , − S O 2 − C 1 − C 4 − a l k y l -SO_2-C_1-C_4-alkyl C 1 -C 4 -alkyl, -S-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, -S(O)-C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, –SO 2 -C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and (C 1 -C 4 - a l k o x y ) 2 P ( = O ) − ; alkoxy)_2P(=O)-; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, -OH, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms; phenyl, benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, -OH, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 - C 4 -halogenoalkoxy having 1 to 5 halogen atoms, R 11 R^{11} is selected from the group consisting of C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, C 1 -C 4 - alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, and C 3 -C 6 -cycloalkyl; and heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substitutent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, -OH, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms; R 12 R^{12} is selected from the group consisting of hydrogen; C 1 -C 4 -alkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 - C 4 C_4 -alkoxy, and C 1 C_1 - C 4 C_4 -halogenoalkoxy having 1 to 5 halogen atoms; Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: Z 1 Z^{1} , Z 2 Z^{2} , Z 3 Z^{3} , Z 4 Z^{4} , and Z 5 Z^{5} are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C 1 -C 4 - alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -NH(C 1 -C 4 -alkyl), -N(C 1 -C 4 - alkyl) 2 , -NH(C 3 -C 6 -cycloalkyl), -N(C 1 -C 4 -alkyl)(C 3 -C 6 -cycloalkyl), 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, -S-(C 1 -C 4 -alkyl), -S(O)- ( C 1 − C 4 − a l k y l ) (C_1-C_4-alkyl) , and − S O 2 − ( C 1 − C 4 − a l k y l ) -SO_2-(C_1-C_4-alkyl) , or Z 1 Z^1 and Z 2 Z^2 form, together with the carbon atoms that they are connected to, a 5- or 6-membered heterocycloalkyl, a 5-membered heteroaryl, or a 6-membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine, and oxo, and Z 3 , Z 4 , and Z 5 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 - alkoxy-C(O)-, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, or Z 2 Z^2 and Z 3 Z^3 form, together with the carbon atoms that they are connected to, a 5- or 6-membered saturated or partially saturated heterocyclic ring, a 5-membered heteroaryl, or a 6- membered heteroaryl, each of which may be optionally substituted with one or two substitutents selected from the group consisting of methyl, fluorine, and oxo, and Z 1 Z^1 , Z 4 Z^4 , and Z 5 Z^5 are independently selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, wherein when Y is O, S or N-R 8 , R 4 is not -OH, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

4. The compound according to claim 1, 2 or 3, wherein: Α is A1 or A2, [Image disponible dans le document PDF, Image available in the PDF document] 0 is 0 or 1, R is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, X is selected from the group consisting of CR 6 R 7 , O, S, and N-R 8 , Y is C R 6 R 7 CR^6R^7 , G is S, O, N-R 8 ℝ 1 \mathbb{R}^1 is hydrogen or C 1 -C 4 -alkyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, halogen, [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] − S R 12 -SR^{12} , − S ( O ) R 12 -S(O)R^{12} , − S O 2 R 12 -SO_2R^{12} ; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl or C 3 -C 6 -cycloalkenyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkoxy-C(O)-, and -C(O)-NH 2 ; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl, and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, -OH, oxo, -COOH, C 1 -C 4 -alkoxy-C(O)-, -C(O)-NH 2 , C 1 -C 4 -alkyl, C 1 -C 4 - alkyl-C(O)-, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, hydroxy-C 1 -C 4 -alkyl-, C 1 -C 4 - alkoxy- C 1 C_1 - C 4 C_4 -alkyl-, -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), -N( C 1 C_1 - C 4 C_4 -alkyl)( C 3 C_3 - C 6 C_6 - cycloalkyl), and 4- to 10-membered heterocycloalkyl, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, halogen, -OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 - cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 - alkoxy, C 1 C_1 - C 4 C_4 -alkyl- C ( O ) C(O) -, -NH 2 , -NH( C 1 C_1 - C 4 C_4 -alkyl), -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH( C 3 C_3 - C 6 C_6 -cycloalkyl), - N ( C 1 − C 4 − a l k y l ) ( C 3 − C 6 − c y c l o a l k y l ) − S − C 1 − C 4 − a l k y l , − S ( O ) − C 1 − C 4 − a l k y l , a n d − S O 2 − C 1 − C 4 − a l k y l , N(C_1-C_4-alkyl)(C_3-C_6-cycloalkyl)-S-C_1-C_4-alkyl, -S(O)-C_1-C_4-alkyl, and -SO_2-C_1-C_4-alkyl, R 4 R^4 is selected from the group consisting of hydrogen, -OH and C 1 -C 4 -alkyl, R 5 R^5 is hydrogen, R 6 R^6 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl, ℝ 7 \mathbb{R}^7 is selected from the group consisting of hydrogen and C 1 C_1 - C 4 C_4 -alkyl, ℝ 8 \mathbb{R}^8 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl, R 9 and R 10 are independently selected from the group consisting of hydrogen, − N H ( − C ( O ) − C 1 − C 4 − a l k y l ) -NH(-C(O)-C_1-C_4-alkyl) , C 1 − C 4 − a l k o x y C_1-C_4-alkoxy ; C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, -COOH, C 1 - C 4 C_4 -alkoxy- C ( O ) C(O) -, − C ( O ) -C(O) -NH 2 , − C ( O ) -C(O) -N( C 1 C_1 - C 4 C_4 -alkyl) 2 , -NH- C ( O ) C(O) - C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - C 4 C_4 -alkyl, C 1 C_1 - alkoxy, C 3 -C 6 -cycloalkyl, -NH 2 , -N(C 1 -C 4 -alkyl) 2 , -S-C 1 -C 4 -alkyl, -S(O)-C 1 -C 4 -alkyl, -SO 2 -C 1 -C 4 - alkyl, and ( C 1 − C 4 − a l k o x y ) 2 P ( = O ) (C_1-C_4-alkoxy)_2P(=O) -; heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, -OH, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and C 1 C_1 - C 4 C_4 -alkoxy; phenyl and benzo-C 5 -C 6 -cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms; and a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, oxo, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 - alkoxy, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, R 11 R^{11} C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -OH, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, and C 3 -C 6 -cycloalkyl; and 4- to 10-membered heterocycloalkyl, R 12 R^{12} is selected from the group consisting of hydrogen; C 1 -C 4 -alkyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of -OH and -COOH; and a 6-membered heteroaryl, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: ℤ 1 \mathbb{Z}^1 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy, ℤ 2 \mathbb{Z}^2 is selected from the group consisting of hydrogen, halogen, -OH, C 1 -C 4 -alkyl, C 1 -C 4 - alkoxy, − N H ( C 1 − C 4 − a l k y l ) -NH(C_1-C_4-alkyl) , − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , − N H ( C 3 − C 6 − c y c l o a l k y l ) -NH(C_3-C_6-cycloalkyl) , − N ( C 1 − C 4 − a l k y l ) ( C 3 − a l k y l ) -N(C_1-C_4-alkyl)(C_3-alkyl) C 6 -cycloalkyl), C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, -S-(C 1 -C 4 -alkyl), and a 4- to 6-membered heterocycloalkyl, and ℤ 3 \mathbb{Z}^3 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, - N H ( C 1 − C 4 − a l k y l ) NH(C_1-C_4-alkyl) , and − N ( C 1 − C 4 − a l k y l ) 2 -N(C_1-C_4-alkyl)_2 , ℤ 4 \mathbb{Z}^4 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy, ℤ 5 \mathbb{Z}^5 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

5. The compound according to claim 1, 2, 3 or 4, wherein: A is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] , G is S, O, N-R 8 , ℝ 1 \mathbb{R}^1 is hydrogen or methyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, chlorine, fluorine, − N R 9 R 10 ; -NR^{9}R^{10}; − O R 11 -OR^{11} ; [Image disponible dans le document PDF, Image available in the PDF document] methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclohexyl, propenyl, cyclopentenyl, cyclohexenyl, each of which is optionally substituted by 1 or 2 substituents independently selected from the group consisting of cyano, ethoxy-C(O)-, and -C(O)-NH 2 ; and a monocyclic or a bicyclic heterocycle selected from the group consisting of azetidine, pyrrolidine, pyrazolidine, imidazolidine, 1,2,4-triazolidine, piperidine, piperazine, tetrahydropyridine, dihydro- 2H-pyrane, 1,2-oxazolidine, 1,2-oxazine, morpholine, thiomorpholine, 3,4-dihydroisoquinoline, 2,3-dihydro-indole, 1,3-dihydro-isoindoel, 3,9-dioxa-7-azabicyclo[3.3.1]nonane, 6-oxa-3- azabicyclo[3.1.1]heptane, 8-oxa-3-azabicyclo[3.2.1]octane, imidazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, 4-oxa-7-azaspiro[2.5] octane, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of fluorine, chlorine, cyano, -OH, oxo, -COOH, methoxy-C(O)-, ethoxy-C(O)-, tert-butoxy-C(O)-, -C(O)-NH 2 , methyl, methyl- C(O)-, trifluoromethyl, hydroxymethyl-, methoxymethyl-, -NH 2 , -NMe 2 , and pyrrolidine, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, methyl, methoxy, and trifluoromethyl, ℝ 8 \mathbb{R}^8 is selected from the group consisting of hydrogen and methyl, R 9 and R 10 are independently selected from the group consisting of hydrogen, -NH(-C(O)-methyl), methoxy; methyl, ethyl, propyl, isopropyl, butyl, isobutyl, cyclopropyl, cyclobutyl, benzyl, 1-phenylethyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of fluorine, -OH, -COOH, methoxy-C(O)-, ethoxy-C(O)-, tert-butoxy-C(O)-, - C(O)-NH 2 , -C(O)-NMe 2 , -NH-C(O)-methyl, methyl, methoxy, cyclopropyl, -NH 2 , NMe 2 , S- methyl, S ( O ) S(O) -methyl, S O 2 SO_2 -methyl, and ( E t O ) 2 P ( = O ) (EtO)_2P(=O) -; heterocyclyl-methyl, heterocyclyl-ethyl, wherein the heterocyclyl substituent is selected from the group consisting of pyrrolidine, morpholine, pyrazole, 1, 2, 4-oxadiazole, pyridine, each of which is optionally substituted by 1 substituent independently selected from the group consisting of fluorine, chlorine, -OH, oxo, and methyl; phenyl; 2,3-dihydro-1H-indene, and a monocyclic or a bicyclic heterocycle selected from the group consisting of oxetane, thietane, pyrrolidine, morpholine, tetrahydropyrane, pyridine and pyrazole, each of which is optionally substituted by 1 or 2 substituents independently selected from the group consisting of fluorine, chlorine, -OH, oxo, and methyl; R 11 R^{11} is selected from the group consisting of methyl, ethyl, isopropyl, butyl, cyclopentyl, and benzyl, each of which is optionally substituted by 1 or 2 substituents independently selected from the group consisting of fluorine, -OH, methyl, methoxy, and cyclopentyl; and a monocyclic or a bicyclic heterocycle selected from the group consisting of pyrrolidin and tetrahydropyran, R 12 R^{12} is selected from the group consisting of methyl and ethyl, each of which is optionally substituted by 1 substituent independently selected from the group consisting of -OH and -COOH; and pyridine, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: 𝒁 1 \mathbf{Z}^1 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, and methoxy, ℤ 2 \mathbb{Z}^2 is selected from the group consisting of hydrogen, fluorine, chlorine, -OH, methyl, ethyl, methoxy, ethoxy, -NH(CH 3 ), -N(CH 3 ) 2 , trifluoromethyl, and trifluoromethoxy, ℤ 3 \mathbb{Z}^3 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, - N H ( C H 3 ) NH(CH_3) , and − N ( C H 3 ) 2 -N(CH_3)_2 , ℤ 4 \mathbb{Z}^4 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, and methoxy, ℤ 5 \mathbb{Z}^5 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, and methoxy, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

6. The compound according to claim 1, 2, 3, 4 or 5, wherein: A is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] , G is S, O, NH, or N-CH 3 , ℝ 1 \mathbb{R}^1 is hydrogen or methyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, chlorine, fluorine, − N H 2 -NH_2 , − N H ( C H 3 ) -NH(CH_3) , − N ( C H 3 ) 2 -N(CH_3)_2 , methoxy, ethoxy, methyl, ethyl, propyl, isopropyl, cyclopropyl, trifluoromethyl, and trifluoromethoxy, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, chlorine, fluorine, methyl, methoxy, and trifluoromethyl, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: 𝒁 1 \mathbf{Z}^1 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, and methoxy, ℤ 2 \mathbb{Z}^2 is selected from the group consisting of hydrogen, fluorine, chlorine, -OH, methyl, ethyl, methoxy, ethoxy, -NH(CH 3 ), -N(CH 3 ) 2 , trifluoromethyl, and trifluoromethoxy, ℤ 3 \mathbb{Z}^3 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, - N H ( C H 3 ) NH(CH_3) , and − N ( C H 3 ) 2 -N(CH_3)_2 , ℤ 4 \mathbb{Z}^4 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl and methoxy, ℤ 5 \mathbb{Z}^5 is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, and methoxy, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

7. The compound according to claim 1, 2, 3, 4, 5 or 6, wherein G is S.

8. A compound of general formula (II): [Image disponible dans le document PDF, Image available in the PDF document] (II), in which: A is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] ℝ 1 \mathbb{R}^1 is hydrogen or methyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of hydrogen, chlorine, fluorine, methoxy, methyl, ethyl, propyl, isopropyl, trifluoromethyl, and trifluoromethoxy, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, chlorine, fluorine, methyl, methoxy, and trifluoromethyl, Q is a substituted phenyl ring of the formula (Q1) - 159 - [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: 𝒁 1 \mathbf{Z}^1 is selected from the group consisting of hydrogen and halogen, ℤ 2 \mathbb{Z}^2 is selected from the group consisting of hydrogen, halogen, -N(C 1 -C 4 -alkyl) 2 , - C 1 -C 4 - halogenoalkyl having 1 to 5 halogen atoms, and C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, ℤ 3 \mathbb{Z}^3 is selected from the group consisting of hydrogen and halogen, ℤ 4 \mathbb{Z}^4 is selected from the group consisting of hydrogen and halogen, ℤ 5 \mathbb{Z}^5 is selected from the group consisting of hydrogen and halogen, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

9. The compound according to claim 8, wherein A is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] , ℝ 1 \mathbb{R}^1 is hydrogen, ℝ 2 \mathbb{R}^2 is isopropyl, ℝ 3 \mathbb{R}^3 is methyl, Q is a substituted phenyl ring of the formula (Q1) [Image disponible dans le document PDF, Image available in the PDF document] (Q1) in which: Z 1 Z^1 , Z 3 Z^3 , Z 4 Z^4 and Z 5 Z^5 are independently selected from the group consisting of hydrogen, fluorine, and chlorine, and ℤ 2 \mathbb{Z}^2 is selected from the group consisting of hydrogen, fluorine, chlorine, -N(CH 3 ) 2 , trifluoromethyl, and trifluoromethoxy, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

10. A method of preparing a compound of general formula (I) as defined in any one of claims 1 to 7 or a compound of general formula (II) as defined in claim 8 or 9, said method comprising the step of allowing an intermediate compound of general formula 1N: [Image disponible dans le document PDF, Image available in the PDF document] 1N, in which G, A, R 1 , R 3 , and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, to react with a compound of general formula 1F: R 2 H R^2H 1F, in which R 2 is selected from the group consisting of –NR 9 R 10 , –OR 11 , and -SR 12 , in which R 9 , R 10 , R 11 and R 12 are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, thereby giving a compound of general formula (I) or (II): [Image disponible dans le document PDF, Image available in the PDF document] (I) (II) in which G, A, R 1 , R 2 , R 3 , and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, or the step of allowing an intermediate compound of general formula 1T: [Image disponible dans le document PDF, Image available in the PDF document] 1T, in which G, A, R 1 , R 2 , and R 3 are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, and in which Hal is halogen, to react with a compound of general formula 1H: [Image disponible dans le document PDF, Image available in the PDF document] 1H, in which Q is as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, and each R may be individually H or Me or both R are pinacolate, thereby giving a compound of general formula (I) or (II): [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] (I) (II) in which G, A, R 1 , R 2 , R 3 , and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, or the step of allowing an intermediate compound of general formula 1W: _ [Image disponible dans le document PDF, Image available in the PDF document] 1W, in which G, Q, R 2 , and R 3 are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, to react with a compound of general formula 1M: [Image disponible dans le document PDF, Image available in the PDF document] 1M, in which R 1 and A are as defined for the compound of general formula (I) in any one of claims 1 to 7, thereby giving a compound of general formula (I) or (II): [Image disponible dans le document PDF, Image available in the PDF document] (I) (II) in which G, A, R 1 , R 2 , R 3 , and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, or the step of allowing an intermediate compound of general formula 1X: [Image disponible dans le document PDF, Image available in the PDF document] 1X, in which G, Q, A, R 1 , and R 3 are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of claim (II) in claim 8 or 9, to react with a compound of general formula 1Y: R 2 H R^2H 1Y, in which R 2 is C 1 -C 4 -alkoxy which is optionally substituted as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, thereby giving a compound of general formula (I) or (II): [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] (I) (II) in which G, A, R 1 , R 3 , and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9 and R 2 is C 1 -C 4 -alkoxy which is optionally substituted as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, or the step of allowing an intermediate compound of general formula 1N: [Image disponible dans le document PDF, Image available in the PDF document] 1N, in which G, Q, A, R 1 , and R 3 are as defined for the compound of general formula (I) in any one of claim 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, to react with a compound of general formula 2A: R 2 Met-X 2A, in which R 2 is C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl- C 1 -C 4 -alkyl, each of which is optionally substituted as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9, Met is magnesium or zinc, and X is chlorine, bromine or iodine, thereby giving a compound of general formula (I) or (II): [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] (I) (II) in which G, A, R 1 , R 3 and Q are as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9 and R 2 is C 1 -C 4 -alkyl, C 3 -C 6 - cycloalkyl, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkenyl, C 2 -C 4 -alkynyl or phenyl-C 1 -C 4 -alkyl, each of which is optionally substituted as defined for the compound of general formula (I) in any one of claims 1 to 7 or as defined for the compound of general formula (II) in claim 8 or 9.

11. A compound of the general formula (VI-INT-1), (VI-INT-2), or (IV-INT-1): [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] (VI-INT-1) (VI-INT-2) [Image disponible dans le document PDF, Image available in the PDF document] (IV-INT-1) in which R A R^{A} is selected from the group consisting of methyl, ethyl and t-butyl, ℝ 2 \mathbb{R}^2 is selected from the group consisting of C 1 -C 6 -alkyl and C 3 -C 6 -cycloalkyl, ℝ 3 \mathbb{R}^3 is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl and C 3 -C 6 -cycloalkyl, and A and R 1 are as defined in any one of claims 1 to 9.

12. Use of a compound of the general formula (VI-INT-1), (VI-INT-2), or (IV-INT-1) as defined in claim 11 for the preparation of a compound of general formula (I) as defined in any one of claims 1 to 7 and a compound of general formula (II) as defined in claim 8 or 9.

13. A compound of general formula (I) as defined in any one of claims 1 to 7 or a compound of general formula (II) as defined in claim 8 or 9 for use in the control, treatment and / or prevention of a disease.

14. The compound of general formula (I) for use according to claim 13, wherein the disease is a helminthic infection.

15. A pharmaceutical composition comprising a compound of general formula (I) as defined in any one of claims 1 to 7 or a compound of general formula (II) as defined in claim 8 or 9 and one or more pharmaceutically acceptable excipients.

16. Use of a compound of general formula (I) as defined in any one of claims 1 to 7 or a compound of general formula (II) as defined in claim 8 or 9 for the control, treatment and / or prevention of a disease.

17. Use of a compound of general formula (I) as defined in any one of claims 1 to 7 or a compound of general formula (II) as defined in claim 8 or 9 for the preparation of a medicament for the control, treatment and / or prevention of a disease.

18. The use according to claim 16 or 17, wherein the disease is a helminthic infection.