Particles of a mixture of iron(III)-oxyhydroxide, sucrose and one or more starches, preferably of sucroferric oxyhydroxide
Agglomerated sucroferric oxyhydroxide particles with a specific particle size distribution address the issue of dark brown marks in micro-tablets, enabling the production of smaller tablets suitable for pediatric applications.
Patent Information
- Authority / Receiving Office
- CA · CA
- Patent Type
- Patents
- Current Assignee / Owner
- VIFOR FRESENIUS MEDICAL CARE RENAL PHARMA LTD
- Filing Date
- 2021-01-14
- Publication Date
- 2026-07-07
AI Technical Summary
Existing sucroferric oxyhydroxide compositions used in micro-tableting processes result in unwanted dark brown marks on the extremities of the micro-tables, which are not desirable for pediatric applications, and the use of the said sucroferric oxyhydroxide compositions lead to dark brown marks on the extremities of the micro-tablets due to higher ejection forces in micro-tableting tools.
The use of agglomerated sucroferric oxyhydroxide particles, comprising iron(III)-oxyhydroxide, sucrose, and one or more starches, with a specific particle size distribution, reduces the fraction of smaller particles and increases the fraction of larger particles, allowing for the production of smaller tablets without dark brown marks.
The agglomerated particles enable the manufacture of suitable smaller tablets, such as micro- or mini-tablets, without the formation of dark brown marks, suitable for pediatric applications or patients with dysphagia.