Benzimidazolone-based cinnamamide derivative as TRPV1 antagonist and pharmaceutical composition for treatment or prevention of pain containing same as active ingredient

Abstract

The present invention relates to a benzimidazolone-based cinnamamide derivative of formula 1: (see formula 1) as a TRPV1 antagonist and a pharmaceutical composition for treating or preventing pain containing the same as an active ingredient. The example compounds provided in one aspect of the present invention block the TRPV1 activation caused by capsaicin, a TRPV1 receptor activator, but induce an appropriate inhibition of about 20% to 80% of pH, thereby the compounds have effects of alleviating pain and effectively reducing side effects such as abnormal body temperature .

Description

BENZIMIDAZOLONE-BASED CINNAMAMIDE DERIVATIVE AS TRPV1 ANTAGONIST AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF PAIN CONTAINING SAME AS ACTIVE INGREDIENT BACKGROUND OF THE INVENTION 1 Field of the Invention The present invention relates to a benzimidazolone-based cinnamamide derivative as a TRPV1 antagonist and a pharmaceutical composition for treating or preventing pain containing the same as an active ingredient. 2. Description of the Related Art Transient receptor potential vanilloid-1 (TRPV1) is one of the subfamily of TRP (transient receptor potential) channel, a cation channel protein found in various tissues of animals, and is a non-selective cation channel mainly expressed in primary sensory neurons. In addition, TRPV1 plays an important role in pain transmission as a nociceptor and pain-sensing transducer involved in transduction, the first step of the nociceptive pathway, which is a process of accepting pain. TRPV1 also maintains the inflammatory state that appears after tissue damage caused by trauma, infection, surgery, burns, and disease and is involved in inflammatory temperature-hypersensitivity reaction. In other words, TRPV1 is a 'gateway of pain' that recognizes and transmits pain in the human body, and through inhibition of TRPV1 function, it can selectively block inappropriate pain perception while maintaining normal sensation, thus TRPV1 is in the spotlight as a target for the development of analgesics. Research on the development of analgesics targeting TRPV1 is largely divided into two mechanisms: agonists and antagonists. In the case of agonists, like ligands, they bind to receptors and deliver pain, and show analgesic effects through desensitization after the threshold. Therefore, agonists have side effects such as initial pain, burning pain and discomfort, so they are being developed only as transdermal analgesics. In contrast, TRPV1 antagonists bind to TRPV1 receptors competitively with the ligands and inhibit pain transmission itself by TRPV1. Therefore, TRPV1 antagonists do not have side effects such as agonist- induced burning sensation and initial pain, and also have no strong irritation, so they can be developed as oral formulations. Specifically, TRPV1 antagonists are spotlighted as a target for the development of new nonopioid analgesics applicable to neuropathic pain, inflammatory pain and cancer pain, which require the development of specialized therapeutic agents due to low efficacy and side effects. In fact, a number of multinational pharmaceutical companies, including Abbott and Amgen, have conducted the development of TRPV1 antagonists. As a result of evaluating the efficacy of low-molecular TRPV1 antagonists in non- clinical animal experiments, the efficacy of TRPV1 antagonists showing selective and strong antagonism was confirmed. However, the first-generation TRPV1 antagonist ABT-102, which has been reported as a strong TRPV1 antagonist, has been shown to increase body temperature lasting more than 2 days in rodents. In the case of AMG 517 developed by Amgen, it showed excellent analgesic efficacy as an antagonist, but it is known that the subject's body temperature rose to 40.2°C and lasted for 1 to 5 days during clinical trials, resulting in a very fatal side effect. In addition, it was confirmed that some TRPV1 antagonists, including Amgen's AMG7905 and AMG8562, cause hypothermia even in the absence of partial agonism. Therefore, in the development of TRPV1 antagonists, the resolution of abnormal body temperature is raised as an important issue. The side effect of raising body temperature of most of the first-generation TRPV1 antagonists developed so far is presumed to be due to antagonism against all activators (capsaicin, heat, pH, NADA, etc.) of the TRPV1 receptor. In particular, capsaicin, one of alkaloids, when ingested, stimulates TRPV1, one of the receptor activation channels, and does not actually increase the temperature, but induces intense fever. In addition, it has been reported that blocking 100% of pH among the TRPV1 receptor activators caused an increase in body temperature, and blocking 20% or less caused proton activation at a high concentration to cause a decrease in body temperature. That is, in the development of TRPV1 antagonists, while blocking TRPV1 activation due to capsaicin and heat, overcoming the abnormal body temperature phenomenon by deriving a selective key strategy that moderately inhibits pH <semantics>(20%−80%)<annotation encoding="application / x-tex">(20\%-80\%)< / annotation>< / semantics> is the most important task. Referring to the prior art, Patent Reference 1 (WO 2011 / 120604 A1) discloses a TRPV1 antagonist compound and a pharmaceutical composition comprising the same as an active ingredient, and the compound inhibits the vanilloid receptor TRPV1, thereby alleviating pain and treating diseases such as dry eyes. On the other hand, the compound of the present invention inhibits the TRPV1 activation caused by capsaicin, but exhibits a TRPV1 inhibitory activity of 20%-80% with respect to pH, thereby having an analgesic effect and no side effect of body temperature change, and has excellent absorption rate in the body. Therefore, the compound of the present invention has the differences described below from the contents of Patent Reference 1 (WO 2011 / 120604 A1) mentioned above. First, in the compound of the present invention, the A region is 4-amino-1,3-dihydro-2H- benzo[d]imidazole-2-one derivative, the B region (linker part) is acrylamide, propanamide or cyclopropane-1-carboxamide, and the C region is phenyl, pyridine, pyrazole or thiazole. On the other hand, in the compound disclosed in Patent Reference 1 (WO <semantics>2011 / 120604<annotation encoding="application / x-tex">2011 / 120604< / annotation>< / semantics> A1), the A region is often benzoheterocycloalkene, the B region is urea or amide, and other substituents including the C region are different. Therefore, the compound has a different chemical structure from the compound of the present invention as a whole. In addition, the compound of the present invention blocks the TRPV1 activation caused by capsaicin and heat, but exhibits a TRPV1 inhibitory activity of 20%-80% with respect to pH, so that it is possible to prepare an analgesic having an analgesic effect, but not having an abnormal body temperature effect and having an excellent absorption rate in the body. On the other hand, the Patent Reference 1 (WO 2011 / 120604 A1) mentioned above only discloses an inhibitory effect on the TRPV1 activation caused by capsaicin in experimental examples, but does not disclose the TRPV1 inhibitory activity of a certain range for pH, the side effect of body temperature change and the absorption rate of the compound. Therefore, there is a difference between the compound of the present invention and the compound of the Patent Reference 1 in terms of the effectiveness of the invention. That is, the compound of the present invention inhibits the TRPV1 activation caused by capsaicin, but exhibits the TRPV1 inhibitory activity of 20%-80% with respect to pH, so it has an analgesic effect, has no side effect of body temperature change, and has an excellent absorption rate in the body. Therefore, the present inventors have completed the present invention by demonstrating that the compound can be effectively used for analgesic. SUMMARY OF THE INVENTION It is an object of the present invention to provide a benzimidazolone-based cinnamamide derivative compound that blocks the TRPV1 activation caused by capsaicin, an activator of the TRPV1 receptor, but induces an appropriate inhibition of 20% to 80% of pH to relieve pain and effectively reduce side effects such as abnormal body temperature. It is another object of the present invention to provide a pharmaceutical composition for preventing or treating pain containing the above compound as an active ingredient. It is another object of the present invention to provide a health functional food composition for preventing or ameliorating pain containing the above compound as an active ingredient. It is another object of the present invention to provide a method for treating pain comprising a step of administering the above compound to a subject in need. It is another object of the present invention to provide the above compound for use in the prevention or treatment of pain. It is another object of the present invention to provide a use of the above compound for the preparation of a medicament for the prevention or treatment of pain. To achieve the above objects, in one aspect of the present invention, the present invention provides a compound represented by formula 1 described herein, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof. In another aspect of the present invention, the present invention provides a pharmaceutical composition for preventing or treating pain containing the above compound as an active ingredient. In another aspect of the present invention, the present invention provides a health functional food composition for preventing or ameliorating pain containing the above compound as an active ingredient. In another aspect of the present invention, the present invention provides a method for treating pain comprising a step of administering the above compound to a subject in need. In another aspect of the present invention, the present invention provides the above compound for use in the prevention or treatment of pain. In another aspect of the present invention, the present invention provides a use of the above compound for the preparation of a medicament for the prevention or treatment of pain. ADVANTAGEOUS EFFECT The example compounds provided in one aspect of the present invention block the TRPV1 activation caused by capsaicin, a TRPV1 receptor activator, but induce an appropriate inhibition of about 20% to 80% of pH, thereby the compounds have effects of alleviating pain and effectively reducing side effects such as abnormal body temperature. DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention is described in detail. The embodiments of this invention can be modified in various other forms, and the scope of the present invention is not limited to the embodiments described below. It is well understood by those in the art who has the average knowledge on this field that the embodiments of the present invention are given to explain the present invention more precisely. In addition, the "inclusion" of an element throughout the specification does not exclude other elements, but may include other elements, unless specifically stated otherwise. In one aspect of the present invention, the present invention provides a compound represented by formula 1 below, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof. [Formula 1] [Image disponible dans le document PDF, Image available in the PDF document] In formula 1 above, <semantics>X1<annotation encoding="application / x-tex">X^1< / annotation>< / semantics> and <semantics>X2<annotation encoding="application / x-tex">X^2< / annotation>< / semantics> are independently hydrogen, or form C=C double bond by linking with the carbon atom to which they are attached, or form 3-6 membered cycloalkylene by linking with the carbon atom to which they are attached; and [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted 5-10 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, or unsubstituted or substituted C6-10 aryl, wherein the substituted 5-10 membered heteroaryl and <semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics> aryl are independently 5-10 membered heteroaryl and <semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics> aryl substituted with at least one substituent selected from the group consisting of <semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics> straight or branched alkynyl, <semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics> cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-8 membered heterocycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl containing at least one heteroatom selected from the group consisting of N and O, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>, <semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics> aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, and 5-8 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>ℝ1<annotation encoding="application / x-tex">\mathbb{R}^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics> straight or branched alkyl, <semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics> is <semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl, <semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics> is <semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl. In another aspect, <semantics>X1<annotation encoding="application / x-tex">X^1< / annotation>< / semantics> and <semantics>X2<annotation encoding="application / x-tex">X^2< / annotation>< / semantics> are independently hydrogen, or form C=C double bond by linking with the carbon atom to which they are attached, or form 3-5 membered cycloalkylene by linking with the carbon atom to which they are attached; and [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted 5-8 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, or unsubstituted or substituted <semantics>C6−8<annotation encoding="application / x-tex">C_{6-8}< / annotation>< / semantics> aryl, wherein the substituted 5-8 membered heteroaryl and <semantics>C6−8<annotation encoding="application / x-tex">C_{6-8}< / annotation>< / semantics> aryl are independently 5-8 membered heteroaryl and <semantics>C6−8<annotation encoding="application / x-tex">C_{6-8}< / annotation>< / semantics> aryl substituted with at least one substituent selected from the group consisting of <semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics> straight or branched alkynyl, <semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics> cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-6 membered heterocycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl containing at least one heteroatom selected from the group consisting of N and O, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>, <semantics>C6−8<annotation encoding="application / x-tex">C_{6-8}< / annotation>< / semantics> aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, and 5-6 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics> straight or branched alkyl, <semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics> is <semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl, <semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics> is <semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl. In another aspect, <semantics>X1<annotation encoding="application / x-tex">X^1< / annotation>< / semantics> and <semantics>X2<annotation encoding="application / x-tex">X^2< / annotation>< / semantics> are independently hydrogen, or form C=C double bond by linking with the carbon atom to which they are attached, or form 3-4 membered cycloalkylene by linking with the carbon atom to which they are attached; and [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted 5-6 membered heteroaryl containing at least one heteroatom selected from the group consisting of N and S, or unsubstituted or substituted C6 aryl, wherein the substituted 5-6 membered heteroaryl and C6 aryl are independently 5-6 membered heteroaryl and C6 aryl substituted with at least one substituent selected from the group consisting of <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkynyl, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-6 membered heterocycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl containing at least one heteroatom selected from the group consisting of N and O, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>, <semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics> aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, and 5 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, <semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl, <semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl. In another aspect, <semantics>X1<annotation encoding="application / x-tex">X^1< / annotation>< / semantics> and <semantics>X2<annotation encoding="application / x-tex">X^2< / annotation>< / semantics> are independently hydrogen, or form C=C double bond by linking with the carbon atom to which they are attached, or form cyclopropylene by linking with the carbon atom to which they are attached; and [Image disponible dans le document PDF, Image available in the PDF document] 5 [Image disponible dans le document PDF, Image available in the PDF document] The compound represented by formula 1 can be any one compound selected from the following compound group. (1) <semantics>(E)−3−(2−(4−methylpiperidin−1−yl)−6−<annotation encoding="application / x-tex">(E)-3-(2-(4-methylpiperidin-1-yl)-6-< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (2) <semantics>(E)−3−(2−(4−ethylpiperidin−1−yl)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (4 - \text{ethylpiperidin} -1 - \text{yl}) -6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (3) <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−<annotation encoding="application / x-tex">(E)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-< / annotation>< / semantics> <semantics>4−y1)−3−(2−(pyrrolidin−1−y1)−6−<annotation encoding="application / x-tex">4-y1)-3-(2-(pyrrolidin-1-y1)-6-< / annotation>< / semantics> (trifluoromethyl) pyridin-3-yl) acrylamide; (4) <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo [d] imidazol -< / annotation>< / semantics> <semantics>4−y1)−3−(2−(piperidin−1−y1)−6−<annotation encoding="application / x-tex">4-y1)-3-(2-(piperidin-1-y1)-6-< / annotation>< / semantics> (trifluoromethyl) pyridin-3-yl) acrylamide; (5) <semantics>(E)−3−(2−morpholino−6−<annotation encoding="application / x-tex">(E) -3 - (2 - morpholino - 6 -< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (6) <semantics>(E)−3−(2−(diethylamino)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (diethylamino) -6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (7) <semantics>(E)−3−(2−(dipropylamino)−6−<annotation encoding="application / x-tex">(E)-3-(2-(dipropylamino)-6-< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (8) <semantics>(E)−3−(2−butoxy−6−(trifluoromethyl)pyridin−3−<annotation encoding="application / x-tex">(E)-3-(2-butoxy-6-(trifluoromethyl)pyridin-3-< / annotation>< / semantics> yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4- yl)acrylamide; (9) <semantics>(E)−3−(2−(hexyloxy)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (hexyloxy) -6 -< / annotation>< / semantics> 5 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (10) <semantics>(E)−3−(2−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6<annotation encoding="application / x-tex">(E) - 3 - (2 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6 - isobutoxy - 6< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; 10 (11) <semantics>(E)−3−(2−cyclobutoxy−6−<annotation encoding="application / x-tex">(E) -3 - (2 - cyclobutoxy - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (12) <semantics>(E)−3−(2−(cyclopentyloxy)−6−<annotation encoding="application / x-tex">(E) - 3 - (2 - (cyclopentyloxy) - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 15 1H-benzo[d]imidazol-4-yl)acrylamide; (13) <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−<annotation encoding="application / x-tex">(E)-3-(2-(cyclopropylmethoxy)-6-< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (14) <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−1H−1H−1H−1H−1H−1H−1<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - 1H - 1H - 1H - 1H - 1H - 1H - 1< / annotation>< / semantics> 20 benzo[d]imidazol-<semantics>4<annotation encoding="application / x-tex">4< / annotation>< / semantics>-yl)-3-(2-(2,2,2-trifluoroethoxy)-6- (trifluoromethyl) pyridin-3-yl) acrylamide; (15) <semantics>(E)−3−(2−(neopentyloxy)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (neopentyloxy) -6 -< / annotation>< / semantics> (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; <semantics>(E)−3−(2−((2−methylcyclopropyl)methoxy)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - ((2 - methylcyclopropyl) methoxy) -6 -< / annotation>< / semantics> (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (17) <semantics>(E)−3−(6−(chlorodifluoromethyl)−2−<annotation encoding="application / x-tex">(E) - 3 - (6 - (chlorodifluoromethyl) - 2 -< / annotation>< / semantics> <semantics>(cyclopropylmethoxy)<annotation encoding="application / x-tex">(cyclopropylmethoxy)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−<annotation encoding="application / x-tex">(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (18) <semantics>(E)<annotation encoding="application / x-tex">(E)< / annotation>< / semantics> -3-<semantics>(6<annotation encoding="application / x-tex">(6< / annotation>< / semantics>-cyclopropyl-2- <semantics>(cyclopropylmethoxy)<annotation encoding="application / x-tex">(cyclopropylmethoxy)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−<annotation encoding="application / x-tex">(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (19) [Image disponible dans le document PDF, Image available in the PDF document] isopropylpyridin-3-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (20) <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(1−<annotation encoding="application / x-tex">(E)-3-(2-(cyclopropylmethoxy)-6-(1-< / annotation>< / semantics> methylcyclopropyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (21) [Image disponible dans le document PDF, Image available in the PDF document] <semantics>(difluoromethyl)<annotation encoding="application / x-tex">(difluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">(2-oxo-2, 3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)acrylamide; (22) <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(1,1−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - (1, 1 -< / annotation>< / semantics> difluoroethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (23) [Image disponible dans le document PDF, Image available in the PDF document] (cyclopropylmethoxy)pyridin-3-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (24) <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(2−<annotation encoding="application / x-tex">(E)-3-(2-(cyclopropylmethoxy)-6-(2-< / annotation>< / semantics> hydroxypropan-2-yl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (25) <semantics>(E)−3−(2−(cyclobutylmethoxy)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclobutylmethoxy) -6 -< / annotation>< / semantics> (trifluoromethyl) pyridin<semantics>−3−y1<annotation encoding="application / x-tex">-3-y1< / annotation>< / semantics>) <semantics>−N−(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">-N-(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (26) <semantics>(E)−3−(2−(cyclopentylmethoxy)−6−<annotation encoding="application / x-tex">(E) - 3 - (2 - (cyclopentylmethoxy) - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (27) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (28) <semantics>(E)−3−(2−((cyclopropylmethyl)thio)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - ((cyclopropylmethyl)thio) -6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (29) <semantics>(E)−3−(2−(cyclohexylthio)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclohexylthio) -6 -< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (30) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (31) <semantics>(E)−3−(2−(3−chlorophenyl)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (3 - chlorophenyl) -6 -< / annotation>< / semantics> (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (33) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (34) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (35) [Image disponible dans le document PDF, Image available in the PDF document] benzo[d]imidazol-<semantics>4<annotation encoding="application / x-tex">4< / annotation>< / semantics>-yl)-3-(2-(thiophen-2-yl)-6- (trifluoromethyl) pyridin-3-yl) acrylamide; (36) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (37) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (38) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (39) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (41) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (42) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) phenyl) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (43) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) phenyl) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (44) [Image disponible dans le document PDF, Image available in the PDF document] hydroxypropan-2-yl)phenyl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (45) [Image disponible dans le document PDF, Image available in the PDF document] <semantics>(cyclopropylmethoxy)<annotation encoding="application / x-tex">(cyclopropylmethoxy)< / annotation>< / semantics> phenyl) -N-<semantics>(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">(2-oxo-2, 3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)acrylamide; (46) [Image disponible dans le document PDF, Image available in the PDF document] (cyclopropylmethoxy) phenyl) -N-(2-oxo-2, 3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (47) [Image disponible dans le document PDF, Image available in the PDF document] <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−1H−1H−1H−1H−1H−1H−1<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - 1H - 1H - 1H - 1H - 1H - 1H - 1< / annotation>< / semantics> benzo[d]imidazol-<semantics>4−y1<annotation encoding="application / x-tex">4-y1< / annotation>< / semantics>)-3-(1-(m-toly1)-3- (trifluoromethyl) -1H-pyrazol-5-yl)acrylamide; (49) <semantics>(E)−3−(1−(3−chloro−4−fluorophenyl)−3−<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - chloro - 4 - fluorophenyl) - 3 -< / annotation>< / semantics> <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−yl)<annotation encoding="application / x-tex">(trifluoromethyl) - 1H - pyrazol - 5 - yl) - N - (2 - oxo - 2, 3 - yl)< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (50) <semantics>(E)−3−(1−(3−isopropylphenyl)−3−<annotation encoding="application / x-tex">(E)-3-(1-(3-isopropylphenyl)-3-< / annotation>< / semantics> <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (51) [Image disponible dans le document PDF, Image available in the PDF document] <semantics>pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)acrylamide; (52) [Image disponible dans le document PDF, Image available in the PDF document] methylcyclopropyl) <semantics>−1H<annotation encoding="application / x-tex">-1H< / annotation>< / semantics>-pyrazol-5-yl) <semantics>−N<annotation encoding="application / x-tex">-N< / annotation>< / semantics>-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; (53) <semantics>(E)−3−(3−(tert−butyl)−1−(3−chlorophenyl)−1H−<annotation encoding="application / x-tex">(E) -3 - (3 - (tert-butyl) -1 - (3-chlorophenyl) -1H-< / annotation>< / semantics> <semantics>pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)acrylamide; (54) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) thiazol-5-yl) <semantics>−N−(2−oxo−2,3−dihydro−<annotation encoding="application / x-tex">-N-(2-oxo-2,3-dihydro-< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide; (55) [Image disponible dans le document PDF, Image available in the PDF document] isopropylthiazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; [Image disponible dans le document PDF, Image available in the PDF document] cyclopropylthiazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; (57) [Image disponible dans le document PDF, Image available in the PDF document] methylcyclopropyl)thiazol-5-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide; (58) [Image disponible dans le document PDF, Image available in the PDF document] chlorophenyl) thiazol-5-yl) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide; <semantics>(59)<annotation encoding="application / x-tex">(59)< / annotation>< / semantics> 3-<semantics>(2−isobutoxy−6−(trifluoromethyl)pyridin−3−<annotation encoding="application / x-tex">(2-isobutoxy-6-(trifluoromethyl)pyridin-3-< / annotation>< / semantics> yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4- yl)propaneamide; (60) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl) pyridin-3-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)propaneimide; (61) <semantics>2−(2−isobutoxy−6−(trifluoromethyl)pyridin−3−<annotation encoding="application / x-tex">2-(2-isobutoxy-6-(trifluoromethyl)pyridin-3-< / annotation>< / semantics> yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4- yl)cyclopropane-1-carboxamide; (62) [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide; (63) <semantics>2−(1−(3−chlorophenyl)−3−(trifluoromethyl)−<annotation encoding="application / x-tex">2-(1-(3-\text{chlorophenyl})-3-(\text{trifluoromethyl})-< / annotation>< / semantics> <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide; <semantics>(64)<annotation encoding="application / x-tex">(64)< / annotation>< / semantics> 2-<semantics>(1−(3−chlorophenyl)−3−(1,1−difluoroethyl)−<annotation encoding="application / x-tex">(1-(3-chlorophenyl)-3-(1,1-difluoroethyl)-< / annotation>< / semantics> <semantics>1H−pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">1H-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide; (65) <semantics>2−(1−(3−chlorophenyl)−3−isopropyl−1H−<annotation encoding="application / x-tex">2-(1-(3-chlorophenyl)-3-isopropyl-1H-< / annotation>< / semantics> <semantics>pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide; <semantics>(66)2−(1−(3−chlorophenyl)−3−cyclopropyl−1H−<annotation encoding="application / x-tex">(66) 2-(1-(3-chlorophenyl)-3-cyclopropyl-1H-< / annotation>< / semantics> <semantics>pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide; (67) <semantics>2−(1−(3−chlorophenyl)−3−(1−<annotation encoding="application / x-tex">2-(1-(3-chlorophenyl)-3-(1-< / annotation>< / semantics> methylcyclopropyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)cyclopropane-1- carboxamide; and (68) <semantics>2−(3−(tert−butyl)−1−(3−chlorophenyl)−1H−<annotation encoding="application / x-tex">2-(3-(tert-butyl)-1-(3-chlorophenyl)-1H-< / annotation>< / semantics> <semantics>pyrazol−5−yl)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide. In another aspect, [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted 5-6 membered heteroaryl containing at least one heteroatom selected from the group consisting of N and S, wherein the substituted 5-6 membered heteroaryl is 5-6 membered heteroaryl substituted with two substituents selected from the group consisting of <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkynyl, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-6 membered heterocycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl containing at least one heteroatom selected from the group consisting of N and O, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>, <semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics> aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, and 5 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl, <semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl. In another aspect, [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted pyridine, wherein the substituted pyridine is pyridine substituted with two substituents selected from the group consisting of <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkynyl, C3-6 cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-6 membered heterocycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl containing at least one heteroatom selected from the group consisting of N and O, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>, <semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics> aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, and 5 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, <semantics>ℝ3<annotation encoding="application / x-tex">\mathbb{R}^3< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl, <semantics>ℝ4<annotation encoding="application / x-tex">\mathbb{R}^4< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one methyl. The compound represented by formula 1 of the present invention can be used as a form of a pharmaceutically acceptable salt, in which the salt is preferably acid addition salt formed by pharmaceutically acceptable free acids. The acid addition salt herein can be obtained from inorganic acids such as hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, hydrobromic acid, hydroiodic acid, nitrous acid, and phosphorous acid; non-toxic organic acids such as aliphatic mono / dicarboxylate, phenyl-substituted alkanoate, hydroxy alkanoate, alkandioate, aromatic acids, and aliphatic / aromatic sulfonic acids; or organic acids such as trifluoroacetic acid, acetate, benzoic acid, citric acid, lactic acid, maleic acid, gluconic acid, methanesulfonic acid, 4-toluenesulfonic acid, tartaric acid and fumaric acid. The pharmaceutically non-toxic salts are exemplified by sulfate, pyrosulfate, bisulfate, sulphite, bisulphite, nitrate, phosphate, monohydrogen phosphate, dihydrogen phosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, fluoride, acetate, propionate, decanoate, caprylate, acrylate, formate, isobutylate, caprate, heptanoate, propiolate, oxalate, malonate, succinate, suberate, cabacate, fumarate, maliate, butyne-1,4- dioate, hexane-1,6-dioate, benzoate, chlorobenzoate, methylbenzoate, dinitrobenzoate, hydroxybenzoate, methoxybenzoate, phthalate, terephthalate, benzenesulfonate, toluenesulfonate, chlorobenzenesulfonate, xylenesulfonate, phenylacetate, phenylpropionate, phenylbutylate, citrate, lactate, hydroxybutylate, glycolate, malate, tartrate, methanesulfonate, propanesulfonate, naphthalene-1-sulfonate, naphthalene-2-sulfonate, and mandelate. The acid addition salt according to the present invention can be prepared by the conventional method known to those in the art. For example, the derivative represented by formula 1 is dissolved in an organic solvent such as methanol, ethanol, acetone, methylene chloride, and acetonitrile, to which organic acid or inorganic acid is added to induce precipitation. Then, the precipitate is filtered and dried to give the salt. Or the solvent and the excessive acid are distillated under reduced pressure, and dried to give the salt. Or the precipitate is crystallized in an organic solvent to give the same. A pharmaceutically acceptable metal salt can be prepared by using a base. Alkali metal or alkali earth metal salt is obtained by the following processes: dissolving the compound in excessive alkali metal hydroxide or alkali earth metal hydroxide solution; filtering non-soluble compound salt; evaporating the remaining solution and drying thereof. At this time, the metal salt is preferably prepared in the pharmaceutically suitable form of sodium, potassium, or calcium salt. And the corresponding salt is prepared by the reaction of alkali metal or alkali earth metal salt with proper silver salt (ex; silver nitrate). In addition, the present invention includes not only the compound represented by formula 1 but also a pharmaceutically acceptable salt thereof, and a solvate, an optical isomer, or a hydrate possibly produced from the same. The term "hydrate" refers to a compound or a salt thereof of the present invention containing a stoichiometric or non-stoichiometric amount of water bound by a non-covalent intermolecular force. The hydrate of the compound represented by formula 1 of the present invention can contain a stoichiometric or non-stoichiometric amount of water bonded by a non- covalent intermolecular force. The hydrate can contain 1 equivalent or more of water, preferably 1 to 5 equivalents of water. The hydrate can be prepared by crystallizing the compound represented by formula 1, the isomer thereof, or the pharmaceutically acceptable salt thereof from water or the solvent containing water. The term "solvate" refers to a compound or a salt thereof of the present invention containing a stoichiometric or non-stoichiometric amount of solvent bound by a non-covalent intermolecular force. Preferred solvents therefor include volatile, non- toxic, and / or solvents suitable for administration to human. The term "isomer" refers to a compound or a salt thereof of the present invention having the same chemical formula or molecular formula, but structurally or sterically different. Such isomers include structural isomers such as tautomers, R or S isomers having an asymmetric carbon center, stereoisomers such as geometric isomers (trans, cis), and optical isomers (enantiomers). All these isomers and mixtures thereof are also included in the scope of the present invention. In another aspect of the present invention, the present invention provides a pharmaceutical composition for preventing or treating pain containing the compound represented by formula 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof as an active ingredient. At this time, the compound may exhibit a preventive or therapeutic activity for pain by inhibiting TRPV1 (transient receptor potential vanilloid-1) receptor activators. Preferably, the compound prevents or treats pain by suppressing capsaicin, a TRPV1 (transient receptor potential vanilloid-1) receptor activator, and inhibits pH in the range of 20% to 80% to reduce side effects such as abnormal body temperature. The compound represented by formula 1 of the present invention or the pharmaceutically acceptable salt thereof can be administered orally or parenterally and be used in general forms of pharmaceutical formulation. That is, the compound or the pharmaceutically acceptable salt thereof can be prepared for oral or parenteral administration by mixing with generally used diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants. Solid formulations for oral administration are tablets, pills, powders, granules and capsules. These solid formulations are prepared by mixing one or more compounds with one or more suitable excipients such as starch, calcium carbonate, sucrose or lactose, gelatin, etc. Except for the simple excipients, lubricants, for example magnesium stearate, talc, etc, can be used. Liquid formulations for oral administrations are suspensions, solutions, emulsions and syrups, and the above-mentioned formulations can contain various excipients such as wetting agents, sweeteners, aromatics and preservatives in addition to generally used simple diluents such as water and liquid paraffin. Formulations for parenteral administration are sterilized aqueous solutions, water-insoluble excipients, suspensions and emulsions. Water insoluble excipients and suspensions can contain, in addition to the active compound or compounds, propylene glycol, polyethylene glycol, vegetable oil like olive oil, injectable ester like ethylolate, etc. The pharmaceutical composition comprising the compound represented by formula 1 or the pharmaceutically acceptable salt thereof as an active ingredient can be administered by parenterally and the parenteral administration includes subcutaneous injection, intravenous injection, intramuscular injection, or intrathoracic injection. At this time, to prepare the compound represented by formula 1 or the pharmaceutically acceptable salt thereof as a formulation for parenteral administration, the compound represented by formula 1 or the pharmaceutically acceptable salt thereof is mixed with a stabilizer or a buffering agent in water to produce a solution or suspension, which is then formulated as ampoules or vials. The composition herein can be sterilized and additionally contains preservatives, stabilizers, wettable powders or emulsifiers, salts and / or buffers for the regulation of osmotic pressure, and other therapeutically useful materials, and the composition can be formulated by the conventional mixing, granulating or coating method. The formulations for oral administration are exemplified by tablets, pills, hard / soft capsules, solutions, suspensions, emulsions, syrups, granules, elixirs, and troches, etc. These formulations can include diluents (for example, lactose, dextrose, sucrose, mannitol, sorbitol, cellulose, and / or glycine) and lubricants (for example, silica, talc, stearate and its magnesium or calcium salt, and / or polyethylene glycol) in addition to the active ingredient. Tablets can include binding agents such as magnesium aluminum silicate, starch paste, gelatin, methylcellulose, sodium carboxymethylcellulose and / or polyvinylpyrolidone, and if necessary disintegrating agents such as starch, agarose, alginic acid or its sodium salt or azeotropic mixtures and / or absorbents, coloring agents, flavours, and sweeteners can be additionally included thereto. In another aspect of the present invention, the present invention provides an analgesic composition for treating or alleviating pain containing the compound represented by formula 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof as an active ingredient. At this time, the compound may exhibit a therapeutic or alleviating activity for pain by inhibiting TRPV1 (transient receptor potential vanilloid-1) receptor activators. Preferably, the compound treats or alleviates pain by suppressing capsaicin, a TRPV1 (transient receptor potential vanilloid-1) receptor activator, and inhibits pH in the range of 20% to 80% to reduce side effects such as abnormal body temperature. In another aspect of the present invention, the present invention provides a health functional food composition for preventing or ameliorating pain containing the compound represented by formula 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof as an active ingredient. At this time, the compound may exhibit a preventive or ameliorating activity for pain by inhibiting TRPV1 (transient receptor potential vanilloid-1) receptor activators. Preferably, the compound prevents or ameliorates pain by suppressing capsaicin, a TRPV1 (transient receptor potential vanilloid-1) receptor activator, and inhibits pH in the range of 20% to 80% to reduce side effects such as abnormal body temperature. The compound represented by formula 1 according to the present invention can be used as food additive. In that case, the compound can be added as it is or as mixed with other food components according to the conventional method. The mixing ratio of active ingredients can be regulated according to the purpose of use (prevention or amelioration). In general, the amount of the compound in health food can be added in an amount of 0.1 to 90 weight part based on the total weight of the food. However, if long term administration is required for health and hygiene or regulating health condition, the content can be lower than the above but higher content can be accepted as well since the compound has been proved to be very safe. In addition, the health functional beverage composition of the present invention can additionally include various flavors or natural carbohydrates, etc, like other beverages in addition to the compound represented by formula 1. The natural carbohydrates above can be one of monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xilytole, sorbitol and erythritol. Besides, natural sweetening agents (thaumatin, stevia extract, for example rebaudioside A, glycyrrhizin, etc.) and synthetic sweetening agents (saccharin, aspartame, etc.) can be included as a sweetening agent. The content of the natural carbohydrate is preferably 1-20 g and more preferably 5-12 g in 100 g of the composition of the present invention. In addition to the ingredients mentioned above, the compound represented by formula 1 according to the present invention can include in variety of nutrients, vitamins, minerals (electrolytes), flavors including natural flavors and synthetic flavors, coloring agents and extenders (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts, organic acid, protective colloidal viscosifiers, pH regulators, stabilizers, antiseptics, glycerin, alcohols, carbonators which used to be added to soda, etc. The compound represented by formula 1 of the present invention can also include fruit flesh addable to natural fruit juice, fruit beverages and vegetable beverages. In another aspect of the present invention, the present invention provides a pharmaceutical kit for preventing or treating pain comprising a first component containing the compound represented by formula 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof as an active ingredient; and a second component containing an analgesic as an active ingredient. At this time, the analgesic can be used without limitation, as long as it is a known analgesic. The analgesic can be an anti-inflammatory analgesic (NSAID such as a COX inhibitor) or an opioid-based analgesic. Some examples of the analgesic may be acetaminophen, aspirin™, ibuprofen, ketoprofen, meloxicam, diclofenac potassium, etodolac, sulindac, indomethacin, celecoxib, valdecoxib, rofecoxib, celecoxib, hydrocodone, oxymorphone, buprenorphine, fentanyl, hydromorphone, tramadol, and the like, or a combination thereof. In another aspect of the present invention, the present invention provides a method for treating pain comprising a step of administering the above compound to a subject in need. In another aspect of the present invention, the present invention provides the above compound for use in the prevention or treatment of pain. In another aspect of the present invention, the present invention provides a use of the above compound for the preparation of a medicament for the prevention or treatment of pain. The example compounds provided in one aspect of the present invention block the TRPV1 activation caused by capsaicin, a TRPV1 receptor activator, but induce an appropriate inhibition of about 20% to 80% of pH, thereby the compounds have effects of alleviating pain and effectively reducing side effects such as abnormal body temperature. These are directly supported by the examples and experimental examples to be described hereinafter. Hereinafter, the present invention will be described in detail by the following examples and experimental examples. However, the following examples and experimental examples are only for illustrating the present invention, and the contents of the present invention are not limited thereto. Synthesis 1. Synthesis of compounds 1-1. Synthesis of A-region [Reaction Formula 1] Synthesis of A-region (4- amino-1,3-dihydro-2H-benzo[d]imidazol-2-one derivative) [Image disponible dans le document PDF, Image available in the PDF document] <semantics>1−1−1<annotation encoding="application / x-tex">1-1-1< / annotation>< / semantics>. Synthesis of <semantics>4−nitro−1<annotation encoding="application / x-tex">4-\text{nitro}-1< / annotation>< / semantics>, <semantics>3−dihydro−2H−<annotation encoding="application / x-tex">3-\text{dihydro}-2\text{H}-< / annotation>< / semantics> benzo[d]imidazol-2-one P HN- <semantics>O2N<annotation encoding="application / x-tex">O_2N< / annotation>< / semantics> NH 3-Nitrobenzene-1,2-diamine (1 equivalent) was dissolved in acetonitrile, to which triphosgene (1.2 equivalent) was added dropwise at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C for 3-5 minutes, followed by stirring at room temperature for 30 minutes, preferably for 1 hour. The reaction mixture was diluted by slowly adding water dropwise at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, and when no more gas was generated and a dark yellow- green solid began to form, the reaction mixture was stirred at room temperature for 30 minutes, preferably for 1 hour. Then, the produced yellow-green solid was filtered and washed with water to give the target product 4-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one. (Yield: 80-89%) 1-1-2. Synthesis of 4-amino-1,3-dihydro-2H- benzo[d]imidazol-2-one H2N 4-Nitro-1, 3-dihydro-2H-benzo[d]imidazol-2-one (1 equivalent) obtained in the above reaction was hydrogenated with a reducing agent such as 10% palladium-activated carbon (Pd-C) dissolved in lower alcohol such as methanol, filtered, and the filtrate was dried under reduced pressure. The reactant was purified by flash column chromatography filled with silica gel using a mixed solvent of methylene chloride and methyl alcohol as an elution solvent to give the target compound 4-amino-1,3-dihydro-2H- benzo[d]imidazol-2-one. (Yield: 80-85%) 5 1-2. Synthesis of C-region [Reaction Formula 2] Synthesis of pyridine C- region [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_3< / annotation>< / semantics>, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics><semantics>X=N<annotation encoding="application / x-tex">X = N< / annotation>< / semantics>, <semantics>C<annotation encoding="application / x-tex">C< / annotation>< / semantics> <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_3< / annotation>< / semantics>, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> <semantics>X=N<annotation encoding="application / x-tex">X = N< / annotation>< / semantics>, <semantics>C<annotation encoding="application / x-tex">C< / annotation>< / semantics> <semantics>R1=CF3,C(CH2)3<annotation encoding="application / x-tex">R_1 = CF_3, C(CH_2)_3< / annotation>< / semantics>X = N, C Z = OH, F, CI, SH Y = CN, Br Y = CN, Br R2 = methyl piperidine, ethylpiperidine, <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> = methyl piperidine, ethylpiperidine, cyclopentyl, cyclohexyl, morpholine, cyclopentyl, cyclonexyl, morpholine, diethylamine, dipropylamine, propoxy, hexyloxy, diethylamine, dipropylamine, propoxy, hexyloxy, isobutoxy, cyclobutoxy, cyclopentyloxy,2,2,2- cyclopentyloxy,2,2,2-trifluoroethoxy, isobutoxy, cyclobutoxy, trifluoroethoxy, neopentyloxy, 2-methylcyclopropyl)methoxy. 2-mathylcyclopropyl)methoxy. neopentyloxy cyclobutylmethoxy, cyclopentylmethoxy, (2,3-dimethylcyclopropyl)methoxy, (2,3-dimethylcyclopropyl)methoxy, cyclobutylmethoxy, cyclopentylmethoxy, isobutyl sulfane, cyclopropylmethyl sulfane. isobutyl sulfane, cyclopropylmethyl chlorophenyl, 3-isopropylphenyl, cyclohexyl sulfane,3-fluorophenyl, 3- sulfane, cyclohexyl sulfane,3- fluorophenyl, 3-chlorophenyl, 3- thiophen-2-yl, furan-2-yl, 3,3-dimethylbut-1- 3-chloro-4-fluorophenyl, 4-fluorophenyl, 3-chloro-4-fluorophenyl, 4-fluorophenyl, isopropylphenyl, yn-1-yl, 3,3-dimethylbutyl, cyclobutyl, thiophen-2-yl, furan-2-yl, 3,3-dimethylbut- cyclopentyl, cyclohexyl cyclopentyl, cyclohexyl 1-yn-1-yl, 3,3-dimethylbutyl, cyclobutyl, *Y = Br: direct coupling with methyl acrylate [Method 2A] PhaP CO2Me / Et [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] toluene [Method 28] methyl acrylate, Pd(OAC)2: P(o-tol)3, DMF <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_3< / annotation>< / semantics>, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_3< / annotation>< / semantics>, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> <semantics>X=N,C<annotation encoding="application / x-tex">X = N, C< / annotation>< / semantics> X=N,C R2 = methyl piperidine, ethylpiperidine. <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> = methyl piperidine, ethylpiperidine. cyclopentyl, cyclohexyl, morpholine. cyclopentyl, cyclohexyl, morpholine, diethylamine, diethylamine, dipropylamine, propoxy, hexyloxy, dipropylamine,propoxy, hexyloxy, isobutoxy, cyclobutoxy, isobutoxy, cyclobutoxy, cyclopentyloxy,2,2,2-trifluoroethoxy, cyclopentyloxy,2,2,2-trifluoroethoxy, 2-methylcyclopropyl)methoxy, neopentyloxy. 2-methylcyclopropyl)methoxy. neopentyloxy. cyclobutyimethoxy, cyclopentyimethoxy, cyclobutylmethoxy, cyclopentylmethoxy, (2,3-dimethylcyclopropyl)methoxy, (2,3-dimethylcyclopropyl)methoxy, Isobutyl sulfane, cyclopropylmethyl isobutyl sulfane, cyclopropylmethyl sulfane, cyclohexyl sulfane,3- sulfane, cyclohexyl sulfane,3- fluorophenyl, 3-chlorophenyl, 3- fluorophenyl, 3-chlorophenyl, 3- Isopropylphenyl, isopropylphenyl, 3-chlore-4-fluorophenyl, 4-fluorophenyl, 3-chloro-4-fluorophenyl, 4-fluorophenyl, thiophen-2-yl, furan-2-yl, 3,3-dimethylbut- thiophen-2-yl, furan-2-yl, 3,3-dimethylbut- 1-yn-1-yl, 3,3-dimethylbutyl, cyclobutyl, 1-yn-1-yl, 3,3-dimethylbutyl, cyclobutyl, cyclopentyl, cyclohexyl cyclopentyl, cyclonexyl <semantics>R3=CH3<annotation encoding="application / x-tex">R_3 = CH_3< / annotation>< / semantics>, <semantics>CH2CH3<annotation encoding="application / x-tex">CH_2CH_3< / annotation>< / semantics> [Image disponible dans le document PDF, Image available in the PDF document] 1-2-1. Synthesis of R2-pyridine / phenyl [Image disponible dans le document PDF, Image available in the PDF document] 5 [Method 1A] NR / OR As a starting material, pyridine or phenyl in which <semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics> is <semantics>CF3<annotation encoding="application / x-tex">CF_3< / annotation>< / semantics> or <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics>, Y is CN or Br, and Z is OH, Cl, F or SH was dissolved in THF or DMF, to which DBU (2 equivalents), NaH (2 equivalents) or <semantics>K2CO3<annotation encoding="application / x-tex">K_2CO_3< / annotation>< / semantics> (2 equivalents) was added at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, followed by stirring for 5 to 10 minutes. The corresponding NR, OR, Halo- alkyl, and SR (2 equivalents) were dissolved in THF or DMF and added to the stirring mixture, followed by stirring at room temperature for 16 hours. The reaction was terminated by adding water, and the reactant was extracted with ethyl acetate or methylene chloride. The obtained organic layer was washed with brine, dried over magnesium sulfate, and then concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 85%-92%) [Method 1B] C-C As a starting material, 2-chloro-6- (trifluoromethyl) nicotinonitrile (2-chloro-6- (trifluoromethyl) nicotinonitrile) (1 equivalent) was dissolved in toluene and stirred, to which Na2CO3 (24) equivalents) dissolved in water was added, followed by stirring for 5 to 10 minutes. Then, <semantics>Pd(PPh3)4<annotation encoding="application / x-tex">Pd(PPh_3)_4< / annotation>< / semantics> (0.2) equivalent) was added thereto. After the mixture was refluxed for 30 minutes or 3 hours, the reactor temperature was lowered to room temperature. The corresponding boronic acid (2 equivalents) was dissolved in toluene or 1,4-dioxane and added dropwise thereto, and the mixture was refluxed and stirred for 15 hours. Upon completion of the reaction, the temperature of the reactor was lowered to room temperature, and the reactant was filtered with a celite pad filter and concentrated under reduced pressure. The resulting mixture was dissolved in ethyl acetate, washed with brine and water, dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 72%-85%) [Method 1C] C-C As a starting material, 2-chloro-6- (trifluoromethyl) nicotinonitrile (2-chloro-6- (trifluoromethyl) nicotinonitrile) (1 equivalent) was dissolved in toluene and stirred, to which the corresponding Alkyn (2 equivalents), Pd(PPh3)4 (0.2 equivalent), Copper (I) Iodide (0.2 equivalent), and TEA (2 equivalents) were added, and the mixture was refluxed and stirred for 15 hours. Upon completion of the reaction, the temperature of the reactor was lowered to room temperature, and the reactant was filtered with a celite pad filter and concentrated under reduced pressure. The resulting mixture was dissolved in EtOAc, washed with brine and water, dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 65%-73%) 1-2-2. Synthesis of pyridine / phenyl aldehyde [Image disponible dans le document PDF, Image available in the PDF document] Pyridine / phenyl nitrile (1 equivalent) obtained in the above reaction was dissolved in toluene and filled with nitrogen, to which DIBAL-H (1M in toluene, 2 equivalents) was slowly added dropwise at <semantics>−78∘<annotation encoding="application / x-tex">-78^{\circ}< / annotation>< / semantics>C, followed by stirring at the same temperature for 2 hours. The reaction was terminated by adding NH4Cl aqueous solution and the organic material was extracted with EtOAc. The resulting mixture was washed with brine and water, dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 61%-75%) 1-2-3. Synthesis of E-methyl / ethyl acetate [Image disponible dans le document PDF, Image available in the PDF document] [Method 2A] Aldehyde (1 equivalent) obtained in the above reaction was dissolved in toluene, to which methyl (triphenylphosphoranylidene) acetate) or ethyl(triphenylphosphoranylidene)acetate) (2 equivalents) was added, followed by stirring at room temperature for 24 hours. Upon completion of the reaction, toluene was removed by concentration under reduced pressure The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 50%-65%) [Method 2B] Synthesis of methyl <semantics>(E)−3−(2−<annotation encoding="application / x-tex">(E)-3-(2-< / annotation>< / semantics> 5 (cyclopropylmethoxy) -6-(2-hydroxypropan-2-yl)pyridin- 3-yl)acrylate [Image disponible dans le document PDF, Image available in the PDF document] . . In the case of <semantics>2−(5−bromo−6−<annotation encoding="application / x-tex">2-(5-bromo-6-< / annotation>< / semantics> (cyclopropylmethoxy)pyridin-2-yl)propanl-2-ol having bromo in Y, 2-(5-bromo-6-(cyclopropylmethoxy)pyridin- 2-yl)propan-2-ol (1 equivalent) was dissolved in anhydrous DMF, to which methyl acrylate (4 equivalents), <semantics>P(o−tol)3<annotation encoding="application / x-tex">P(o-tol)_3< / annotation>< / semantics> (0.3 equivalent) and triethylamine (10 equivalents) were added, followed by bubbling with inert gas (nitrogen and argon) for at least 5 minutes. The reaction mixture was stirred at room temperature for 10 to 30 minutes. <semantics>Pd(OAc)2<annotation encoding="application / x-tex">Pd(OAc)_2< / annotation>< / semantics> (3) mol%) was added thereto, followed by bubbling with inert gas (nitrogen and argon) for 5 to 10 minutes. Then, the reaction mixture was stirred at 100°C for 24 hours. Upon completion of the reaction, the temperature of the reactor was lowered to room temperature. The reactant was diluted with EtOAc, washed with water and brine, dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 65%) 1-2-4. Synthesis of trifluoromethyl pyridine cyclopropane-1-carboxylate [Image disponible dans le document PDF, Image available in the PDF document] <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> = Methyl cyclopropyl, Methyl isopropyl Trimethyl sulfoxonium iodide (2 equivalents) was dissolved in DMSO, to which NaH (2 equivalents) was added at 0°C, followed by stirring at room temperature for 1 to 2 hours, preferably until a clear mixture was formed. The starting material pyridine acrylate (1 equivalent) obtained in the above reaction was dissolved in a small amount of DMSO, slowly added thereto dropwise, and the mixture was stirred at room temperature for 2 to 4 hours. The reaction was terminated by adding water, and the organic material was extracted with ethyl acetate. The reaction mixture was washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 80%-90%) 1-2-5. Synthesis of pyridine / phenyl acrylic acid and cyclopropane carboxylic acid [Image disponible dans le document PDF, Image available in the PDF document] Pyridine or phenyl acrylate or pyridine cyclopropane carboxylate (1 equivalent) obtained in the above reaction was dissolved in THF, to which LiOH·H2O (2 to 3 equivalents) and the same amount of water were added, followed by stirring at room temperature for 2 to 5 hours. Upon completion of the reaction, 1 N HCl was added at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C to adjust the pH of the reactant to <semantics>2−3<annotation encoding="application / x-tex">2-3< / annotation>< / semantics>. The organic material was extracted with EtOAc, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 85%-98%) 1-3. Synthesis of C-region starting material [Reaction Formula 3] [Image disponible dans le document PDF, Image available in the PDF document] 1-3-1. Synthesis of 2,2-difluoropropionic anhydride While stirring 2,2-difluoropropionic acid (1 equivalent) dissolved in methylene chloride at <semantics>−10∘<annotation encoding="application / x-tex">-10^{\circ}< / annotation>< / semantics>C, oxanyl chloride (1.2 equivalents) was added dropwise thereto, followed by stirring at room temperature for 4 hours. Then, it was used as a starting material for the next reaction in a crude state. 1-3-2. Synthesis of 4-ethoxy difluorobutenone [Image disponible dans le document PDF, Image available in the PDF document] <semantics>X=H,Cl,CH3<annotation encoding="application / x-tex">X = H, Cl, CH_3< / annotation>< / semantics> As starting materials, 2,2-difluoropropionic anhydride obtained in the above reaction or the commercially available 2,2-dihyfluoroacetic anhydride and 2-chloro-2,2-difluoroacetic anhydride (1 equivalent) were dissolved in chloroform, and the temperature of the reactor was lowered to <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, followed by stirring. Ethyl vinyl ether (1.3 equivalents) and pyridine (1.3 equivalents) were added to the reaction mixture, followed by stirring at room temperature for 4 hours. The reaction was terminated by adding 1 N HCl, and the organic material was extracted with methylene chloride, washed with water and brine, and concentrated under reduced pressure at 30°C. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 89-95%) 1-3-3. Synthesis of 2-hydroxynicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] <semantics>X=H,CI,CH3<annotation encoding="application / x-tex">X = H, CI, CH_3< / annotation>< / semantics> 2-Cyano acetamide (1 equivalent) was dissolved in ethanol, to which NaOEt 21% solution in ethanol (1.5 equivalents) was added dropwise, followed by stirring at room temperature for 10 to 20 minutes. After lowering the temperature of the reactor to <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, the starting material (1 equivalent) obtained in the above reaction was added dropwise to the reaction mixture. The reactor temperature was raised and the reaction mixture was reacted under reflux conditions for 5 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the reactant was acidified with 4N HCl, extracted using EtOAc, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 60%-75%) 1-3-4. Synthesis of 2-chloro-nicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] X = H, CI, CH3 The starting material (1 equivalent) obtained in the above reaction was dissolved in phenyl dichlorophosphate and stirred in a sealed tube at 170°C for 3 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the reactant was extracted with EtOAc or ether, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 71%- 82왕) [Reaction Formula 4] Cyclopropyl methyl ketone, NC_ O <semantics>𝖭𝖧2<annotation encoding="application / x-tex">^{\mathsf{NH}_2}< / annotation>< / semantics> ethyl formate, NaH, Toluene, ethanol 1,4-Dioxane neat C6H5OP(O)Cl2, `CN <semantics>1−4−1<annotation encoding="application / x-tex">1-4-1< / annotation>< / semantics>. Synthesis of <semantics>(Z)−3−cyclopropyl−3−oxoprop−<annotation encoding="application / x-tex">(Z)-3-cyclopropyl-3-oxoprop-< / annotation>< / semantics> 1-en-1-olate [Image disponible dans le document PDF, Image available in the PDF document] NaH (1 equivalent) was put into a reaction vessel, and nitrogen gas was charged, to which toluene and ethanol were added, followed by stirring. Cyclopropyl methyl ketone (1 equivalent) and Ethyl formate (1 equivalent) dissolved in toluene were added to the mixture, followed by reaction at room temperature for 15 hours. Upon completion of the reaction, an excess of toluene was added to the reactant, which was filtered and concentrated under reduced pressure to give the target product. (Yield: 81%) <semantics>1−4−2<annotation encoding="application / x-tex">1-4-2< / annotation>< / semantics>. Synthesis of <semantics>6−cyclopropyl−2−<annotation encoding="application / x-tex">6-\text{cyclopropyl}-2-< / annotation>< / semantics> hydroxynicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] (1 equivalent) obtained in the above reaction was dissolved in 1,4-dioxane, to which 2-cyano acetamide (1 equivalent) was added, followed by reflux reaction for 21 hours. Upon completion of the reaction, the temperature of the reactor was lowered to room temperature, and the reactant was filtered. AcOH was added to the obtained filtrate, followed by stirring for 10 to 30 minutes. Then, the reaction mixture was extracted with EtOAc, washed with water and brine, and the resulting mixture was dried over magnesium sulfate and concentrated in vacuo to give the target product. (Yield: 60%-70%) 1-4-3. Synthesis of 2-chloro-6- cyclopropylnicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] 6-Cyclopropyl-2-hydroxynicotinonitrile (1 equivalent) obtained in the above reaction was dissolved in phenyl dichlorophosphate and stirred in a sealed tube at 170°C for 3 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the reactant was extracted with EtOAc or ether, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 71%- 82왕) [Reaction Formula 5] [Image disponible dans le document PDF, Image available in the PDF document] 1-5-1. Synthesis of dimethylamino propen / buten-1- one [Image disponible dans le document PDF, Image available in the PDF document] In a sealed tube, the starting material 3- methylbutan-2-one, or 1-(1-methylcyclopropyl)ethan-1- one, or 3,3-dimethylbutan-2-one was dissolved in excess dimethylformamide dimethyl acetal and stirred at 110°C for 5 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the organic layer was extracted with methylene chloride, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated under reduced pressure at 30°C. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 20%-50%) 1-5-2. Synthesis of 2-hydroxynicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] The starting material (1 equivalent) obtained in the above reaction and cyanide acetamide (1.3 equivalent) were added to a mixture of AcOH and piperidine (1:1.3), followed by stirring under reflux for 24 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the reactant was acidified with 4N HCl, extracted using EtOAc, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 60%-75%) 1-5-3. Synthesis of chloro-nicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] The starting material (1 equivalent) obtained in the above reaction was dissolved in phenyl dichlorophosphate and stirred in a sealed tube at 170°C for 3 hours. Upon completion of the reaction, the reactor temperature was lowered to room temperature, and the reactant was extracted with EtOAc or ether, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 71%- 82왕) [Reaction Formula 6] [Image disponible dans le document PDF, Image available in the PDF document] (methoxycarbonyl)pyridine 1-oxide [Image disponible dans le document PDF, Image available in the PDF document] The starting material methyl 5-bromopicolinate (1.0 equivalent) was dissolved in methylene chloride, to which m-CPBA (2.0 equivalents) was added, followed by stirring under reflux conditions for 20 hours. The temperature of the reactor was cooled down to room temperature, and the reaction was terminated by adding Na2SO3 aqueous solution (saturated Na2SO3). The organic material was extracted with methylene chloride, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 76%-85%) 1-6-2. Synthesis of methyl 5-bromo-6- chloropicolinate [Image disponible dans le document PDF, Image available in the PDF document] An excess of POCl3 was added to 5-bromo-2- (methoxycarbonyl) pyridine 1-oxide) (1 equivalent) obtained in the above reaction at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, and the mixture was stirred at <semantics>95∘<annotation encoding="application / x-tex">95^{\circ}< / annotation>< / semantics>C for 1 hour. The reaction was terminated by adding water. The organic material was extracted with EtOAc, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 68%- 90왕) 1-6-3. Synthesis of 2-(5-bromo-6-chloropyridin-2- yl)propan-2-ol [Image disponible dans le document PDF, Image available in the PDF document] Methyl 5-Bromo-6-chloropicolinate (1 equivalent) obtained in the above reaction was dissolved in THF, to which 3 M CH3MgBr solution in diethyl ether (4.0 equivalents) was added dropwise at 0°C in a nitrogen- filled reactor, followed by stirring at room temperature for 1 hour. The reaction was terminated by adding NH4Cl aqueous solution. The organic layer was extracted with EtOAc, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo to give the target compound. (Yield: 70%-85%) [Reaction Formula 7] [Image disponible dans le document PDF, Image available in the PDF document] 1-7-1. Synthesis of 2-mercapto-6- (trifluoromethyl) nicotinonitrile [Image disponible dans le document PDF, Image available in the PDF document] The starting material 2-chloro-6- (trifluoromethyl) nicotinonitrile (1 equivalent) was dissolved in t-butanol, to which Na2S (1 equivalent) was added, followed by stirring at 150℃ for 20 minutes in a microwave. The reaction was terminated by adding 1 N HCl. The organic layer was extracted with EtOAc, and washed with water and brine. The resulting mixture was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel to give the target compound. (Yield: 60%- 65%) [Reaction Formula 8] Synthesis of 4-cyclopropyl- 2-fluorobenzonitrile [Image disponible dans le document PDF, Image available in the PDF document] 22 1-8-1. Synthesis of 4-cyclopropyl-2- fluorobenzonitrile [Image disponible dans le document PDF, Image available in the PDF document] As a starting material, 4-bromo-2- fluorobenzonitrile (1 equivalent) was dissolved in toluene and stirred, to which Na2CO3 (24 equivalents) dissolved in water was added, followed by stirring for 5 to 10 minutes. Then, <semantics>Pd(PPh3)4<annotation encoding="application / x-tex">Pd(PPh_3)_4< / annotation>< / semantics> (0.2 equivalent) was added to the reaction mixture. After the mixture was stirred under reflux condition for 2 hours, the reactor temperature was lowered to room temperature, to which the corresponding boronic acid (2 equivalents) dissolved in 1,4-dioxane was added dropwise, followed by stirring under reflux condition for 15 hours. Upon completion of the reaction, the temperature of the reactor was lowered to room temperature, and the reactant was filtered with a celite pad filter and concentrated under reduced pressure. The resulting mixture was dissolved in ethyl acetate, washed with brine and water, dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 85%) [Reaction Formula 9] Synthesis of pyrazole C- region [Image disponible dans le document PDF, Image available in the PDF document] 15 1-9-1. Synthesis of NR pyrazole-5-carboxylate [Image disponible dans le document PDF, Image available in the PDF document] <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_3< / annotation>< / semantics> <semantics>CH(CH3)2<annotation encoding="application / x-tex">CH(CH_3)_2< / annotation>< / semantics> C(CH2)2CH3, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> <semantics>R2=CI,CH3,CH(CH3)2<annotation encoding="application / x-tex">R_2 = CI, CH_3, CH(CH_3)_2< / annotation>< / semantics> <semantics>R3=H,F<annotation encoding="application / x-tex">R3 = H, F< / annotation>< / semantics> The starting material 1H-pyrazole-5-carboxylate (1 equivalent) synthesized in reaction formulas 10 to 11 was dissolved in methylene chloride and stirred, to which appropriate acid (2 equivalents), Cu(OAc)2 (1.5 equivalent), and pyridine (2 equivalents) were added, followed by reaction at room temperature for 24 hours. Upon completion of the reaction, the reactant was filtered with a celite pad filter and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 80%-90%) 1-9-2. Synthesis of 1H-pyrazolyl methanol [Image disponible dans le document PDF, Image available in the PDF document] LAH (2 equivalents) was dissolved in THF in a reaction vessel and nitrogen was charged, to which the starting material (1 equivalent) obtained in the above reaction dissolved in THF was added dropwise at 0°C, followed by stirring at room temperature for 30 minutes to 1 hour. Upon completion of the reaction, the temperature of the reactor was lowered to <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, and the reaction was terminated by adding NaHCO3 aqueous 10 solution slowly. The reactant was filtered with a celite pad filter, and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography filled with silica gel using a mixed solvent of methylene chloride and methyl 15 alcohol as an elution solvent to give the target compound. (Yield: 90%-98%) 1-9-3. Synthesis of 1H-pyrazolyl acrylate [Image disponible dans le document PDF, Image available in the PDF document] <semantics>R1=CF3<annotation encoding="application / x-tex">R_1 = CF_{3}< / annotation>< / semantics> <semantics>CH(CH3)2<annotation encoding="application / x-tex">CH(CH_3)_2< / annotation>< / semantics> C(CH2)2CH3, <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> <semantics>R2=CI,CH3<annotation encoding="application / x-tex">R_2 = CI, CH_3< / annotation>< / semantics> CH(CH3)2 <semantics>R3=H,F<annotation encoding="application / x-tex">R3 = H, F< / annotation>< / semantics> The starting material (1 equivalent) obtained by the above reaction was dissolved in toluene, to which MnO2 (1 equivalent) was added, followed by stirring at room temperature for 30 minutes to 1 hour. Methyl (triphenylphosphoranylidene) acetate) (3.5) equivalents) was added to the mixture, followed by reaction under reflux conditions for 24 hours. Upon completion of the reaction, the reactant was filtered with a celite pad filter. The organic material was extracted with EtOAc, washed with brine and water, and the filtrate was dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 75%-90%) 1-9-4. Synthesis of 1H-pyrazolyl cyclopropane-1- carboxylate [Image disponible dans le document PDF, Image available in the PDF document] Trimethyl sulfoxonium iodide (2 equivalents) was dissolved in DMSO, to which NaH (2 equivalents) was added at 0°C, followed by stirring at room temperature for 1 to 2 hours, preferably until a clear mixture was formed. The starting material 1H-pyrazolyl acrylate (1 equivalent) obtained in the above reaction was dissolved in a small amount of DMSO and slowly added dropwise to the mixture, followed by stirring at room temperature for 2 to 4 hours. The reaction was terminated by adding water, and the organic material was extracted with ethyl acetate. The mixture was washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 80%-90%) 1-9-5. Synthesis of carboxylic acid [Image disponible dans le document PDF, Image available in the PDF document] Acrylate or cyclocarboxylate (1 equivalent) obtained in the above reaction was dissolved in THF, to which <semantics>LiOH⋅H2O<annotation encoding="application / x-tex">LiOH \cdot H_2O< / annotation>< / semantics> (2 to 3 equivalents) and the same amount of water were added, followed by stirring at room temperature for 2 to 5 hours. Upon completion of the reaction, 1 N HCl was added at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C to adjust the pH of the reactant to <semantics>2−3<annotation encoding="application / x-tex">2-3< / annotation>< / semantics>. The organic material was extracted with ethyl acetate, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 85%-98%) [Reaction Formula 10] Synthesis of 1H-pyrazole-5- carboxylate [Method A] [Image disponible dans le document PDF, Image available in the PDF document] 1-10-1. Synthesis of methyl 3-(trifluoromethyl)- 1H-pyrazole-5-carboxylate [Image disponible dans le document PDF, Image available in the PDF document] The starting material methylpropionate (1 equivalent) was dissolved in methylene chloride, to which NaNO2 (3 equivalents) dissolved in water was slowly added dropwise, followed by stirring for 10 to 20 minutes. The reactor temperature was lowered to <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, and 3,3,3-trifluorophenylamine (3 equivalents) was added dropwise to the reaction mixture, followed by stirring at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C for 1 to 2 hours. The reaction mixture was stirred at room temperature for 30 minutes, and the reaction was terminated by adding water. The organic material was extracted with methylene chloride, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 65%-88%) [Method B] [Image disponible dans le document PDF, Image available in the PDF document] 1-10-2. Synthesis of 1H-pyrazole-5-carboxylate [Image disponible dans le document PDF, Image available in the PDF document] Methyl-1-methylcyclopropylketone, isopropyl methyl ketone or pinacolone (1 equivalent) was added to a mixture in which t-BuOK (1.5 equivalent) was dissolved in THF at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, to which diethyloxalate (1 equivalent) dissolved in THF was added dropwise, followed by stirring at room temperature for 15 hours. AcOH (0.15 ml / mmol) was added to the mixture and hydrazine monohydrate (1.1 equivalent) was added dropwise thereto, followed by stirring under reflux condition for 3 hours. Upon completion of the reaction, the reactant was concentrated under reduced pressure, water was added to the obtained solid, followed by stirring for 3 to 6 hours. The obtained solid was filtered under reduced pressure and dried to 5 give the target product. (Yield: 80%-91%) [Reaction Formula 11] Synthesis of thiazole C- region [Image disponible dans le document PDF, Image available in the PDF document] 10 1-11-1. Synthesis of methyl 3-(3-chlorophenyl)-3- oxopropanoate [Image disponible dans le document PDF, Image available in the PDF document] NaH (3 equivalents) was dissolved in THF by stirring in a reaction vessel filled with nitrogen. The reactor temperature was lowered to <semantics>0∘C<annotation encoding="application / x-tex">0^{\circ}C< / annotation>< / semantics>, and the starting material <semantics>1−(3−chlorophenyl)<annotation encoding="application / x-tex">1-(3-chlorophenyl)< / annotation>< / semantics> ethan <semantics>−1−one<annotation encoding="application / x-tex">-1-one< / annotation>< / semantics> (1) equivalent) and dimethyl carbonate (3 equivalents) were slowly added dropwise, followed by stirring at room temperature for 10 to 30 minutes. The reactor temperature was raised to <semantics>50∘<annotation encoding="application / x-tex">50^{\circ}< / annotation>< / semantics>C, and the reactant was stirred for 15 hours. The reaction was terminated by adding 1 N HCl at 0°C. The organic material was extracted with ethyl acetate, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 65%-88%) 1-11-2. Synthesis of methyl <semantics>2−chloro−3−(3−<annotation encoding="application / x-tex">2-chloro-3-(3-< / annotation>< / semantics> chlorophenyl)-3-oxopropanoate [Image disponible dans le document PDF, Image available in the PDF document] After dissolving methyl 3-(3-chlorophenyl)-3- oxopropanoate (1 equivalent) obtained in the above reaction in chloroform, the reactor was filled with nitrogen, to which sulfuryl chloride (1.1 equivalent) was added dropwise at 0°C, followed by stirring under reflux condition for 15 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 75%-88%) 1-11-3. Synthesis of R-carboxamide <semantics>R=C(CH2)2CH3,<annotation encoding="application / x-tex">R = C(CH_2)_2CH_3,< / annotation>< / semantics> <semantics>C(CH3)3<annotation encoding="application / x-tex">C(CH_3)_3< / annotation>< / semantics> NHo 1-Methylcyclopropane-1-carboxylic acid or pivalic acid (1 equivalent) was dissolved in toluene in a reaction vessel filled with nitrogen, to which thionylchloride (1.1 equivalent) was added dropwise at 0°C, followed by stirring at room temperature for 5 hours. An excess of NH4OH aqueous solution was slowly added dropwise thereto at sub-zero temperature, followed by stirring at room temperature for 15 hours. The reaction was terminated by adding water. The organic material was extracted with EtOAc, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo to give the target compound. (Yield: 71%-89%) 1-11-4. Synthesis of R-carbothioamide [Image disponible dans le document PDF, Image available in the PDF document] Using 1-methylcyclopropane-1-carboxamide and pivalamide obtained in the above reaction or commercially available isobutyramide and 2,2,2- trifluoroacetamide as starting materials, they were dissolved in THF or toluene, to which Lawesson's reagent (0.6 equivalent) was added, followed by stirring at room temperature for 15 to 30 minutes. Then, the reaction mixture was stirred under reflux condition for 2 hours preferably 4 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of methylene chloride and methanol as an elution solvent to give the target compound. (Yield: 45%-68%) 1-11-5. Synthesis of thiazole-5-carboxylate [Image disponible dans le document PDF, Image available in the PDF document] Methyl 2-chloro-3-(3-chlorophenyl)-3- oxopropanoate (1 equivalent) obtained in the above reaction was dissolved in MeOH or a mixed solution of i-PrOH:n-BuOH (1:1), to which carbothioamide (1.32) equivalent) obtained in 1-11-4 dissolved in the same solvent was added dropwise, followed by stirring at room temperature for 10 to 30 minutes. Then, the reaction mixture was stirred under reflux condition for 15 hours. The reaction was terminated by adding water. The organic material was extracted with ethyl acetate. The organic material was extracted with ethyl acetate, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate and hexane as an elution solvent to give the target compound. (Yield: 65%-88%) 1-11-6. Synthesis of R-(3-chlorophenyl)thiazol-5- 5 yl methanol [Image disponible dans le document PDF, Image available in the PDF document] LAH (2 equivalents) was dissolved in THF in a reaction vessel and nitrogen was charged, to which the starting material thiazole-5-carboxylate (1 10 equivalent) obtained in the above reaction dissolved in THF was added dropwise at 0°C, followed by stirring at room temperature for 30 minutes to 1 hour. The temperature of the reactor was lowered to <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C, and the reaction was terminated by adding NaHCO3 aqueous 15 solution slowly. The reactant was filtered with a celite pad filter and the resulting filtrate was concentrated under reduced pressure. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of 20 methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 90%-98%) 1-11-7. Synthesis of R-(3-chlorophenyl)thiazol-5- yl) methyl acrylate [Image disponible dans le document PDF, Image available in the PDF document] The starting material (1 equivalent) obtained in <semantics>1−11−6<annotation encoding="application / x-tex">1-11-6< / annotation>< / semantics> was dissolved in toluene, to which MnO2 (1 equivalent) was added, followed by stirring at room temperature for 30 minutes to 1 hour. Methyl (triphenylphosphoranylidene) acetate) or ethyl(triphenylphosphoranylidene)acetate) (3.5) equivalents) was added to the mixture, followed by stirring under reflux condition for 24 hours. Upon completion of the reaction, the reactant was filtered with a celite pad filter and the organic material was extracted with ethyl acetate, washed with water and brine. The resulting filtrate was dried over magnesium sulfate, and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 75%-90%) <semantics>1−11−8<annotation encoding="application / x-tex">1-11-8< / annotation>< / semantics>. Synthesis of (E)-R-(3- chlorophenyl) thiazolyl-acrylic acid [Image disponible dans le document PDF, Image available in the PDF document] Acrylate (1 equivalent) obtained in 11-7 was dissolved in THF, to which LiOH·H2O (2 to 3 equivalents) and the same amount of water were added, followed by stirring at room temperature for 2 to 5 hours. Upon completion of the reaction, 1 N HCl was added at <semantics>0∘<annotation encoding="application / x-tex">0^{\circ}< / annotation>< / semantics>C to adjust the pH of the reactant to 2-3. The organic material was extracted with EtOAc, washed with water and brine, and the resulting filtrate was dried over magnesium sulfate and concentrated in vacuo. The obtained residue was purified by flash column chromatography filled with silica gel using a mixed solvent of ethyl acetate, hexane or methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 85%-98%) 1-3. Synthesis of B-region [Reaction Formula 12] EDC coupling [Image disponible dans le document PDF, Image available in the PDF document] <semantics>Rc=pyridine,pyrazole<annotation encoding="application / x-tex">R_c = pyridine, pyrazole< / annotation>< / semantics> 1-12-1. EDC coupling Acrylic acid or cyclopropane-1-carboxylic acid obtained in the above reaction was dissolved in DMA, to which EDC:HCl (1.5 equivalent) and DMAP (1.5 equivalent) were added, followed by stirring at room temperature for 10 to 20 minutes. After adding 4- amino-benzo[d]imidazol-2-one(4-amino-benzo[d]imidazol- 2-one) derivative (2 equivalents) obtained in reaction formulas 1A and 1B, the mixture was stirred at room temperature for 3 hours to preferably 5 hours. The reaction was terminated by adding water. The organic layer was extracted with ethyl acetate or methylene chloride, and concentrated under reduced pressure. The obtained residue was purified by column chromatography to give the target compound. (Yield: 60-88%) [Reaction Formula 13] [Image disponible dans le document PDF, Image available in the PDF document] <semantics>R=OCH2CH(CH3)2<annotation encoding="application / x-tex">R = OCH_2CH(CH_3)_2< / annotation>< / semantics>, <semantics>OCH2CH(CH2)2<annotation encoding="application / x-tex">OCH_2CH(CH_2)_2< / annotation>< / semantics> <semantics>R=OCH2CH(CH3)2<annotation encoding="application / x-tex">R = OCH_2CH(CH_3)_2< / annotation>< / semantics>, <semantics>OCH2CH(CH2)2<annotation encoding="application / x-tex">OCH_2CH(CH_2)_2< / annotation>< / semantics> 1-13-1. Synthesis of 6-(trifluoromethyl)pyridin- <semantics>3−y1)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−<annotation encoding="application / x-tex">3-y1)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-< / annotation>< / semantics> yl)propaneamide(6-(trifluoromethyl)pyridin-3-yl)-N-(2- oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propanamide) <semantics>(E)−3−(2−isobutoxy−6−(trifluoromethyl)pyridin−3−<annotation encoding="application / x-tex">(E) -3 - (2-isobutoxy -6 - (trifluoromethyl)pyridin -3 -< / annotation>< / semantics> yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4- yl) <semantics>acrylamide((E)−3−(2−isobutoxy−6−<annotation encoding="application / x-tex">acrylamide((E)-3-(2-isobutoxy-6-< / annotation>< / semantics> (trifluoromethyl) pyridin<semantics>−3−y1<annotation encoding="application / x-tex">-3-y1< / annotation>< / semantics>) <semantics>−N−(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">-N-(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> <semantics>1H−benzo[d]imidazol−4−yl)acrylamide)<annotation encoding="application / x-tex">1H-benzo[d]imidazol-4-yl)acrylamide)< / annotation>< / semantics> or <semantics>(E)−3−(2−y)<annotation encoding="application / x-tex">(E)-3-(2-y)< / annotation>< / semantics> (cyclopropylmethoxy)-6-(trifluoromethyl)pyridin-3-yl)- N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4- yl) acrylamide <semantics>((E)−3−(2−(cyclopropylmethoxy)−6−<annotation encoding="application / x-tex">((E) -3 - (2 - (cyclopropylmethoxy) -6 -< / annotation>< / semantics> <semantics>(trifluoromethyl)<annotation encoding="application / x-tex">(trifluoromethyl)< / annotation>< / semantics> pyridin-3-yl)-N-<semantics>(2−oxo−2,3−dihydro−1)<annotation encoding="application / x-tex">(2-oxo-2,3-dihydro-1)< / annotation>< / semantics> 1H-benzo[d]imidazol-4-yl)acrylamide) (1 equivalent) obtained in 1-12-1 was hydrogenated with a reducing agent such as 10% palladium-activated carbon (Pd-C) dissolved in lower alcohol such as methanol, filtered with celite pad, and the filtrate was dried under reduced pressure. The reactant was purified by flash column chromatography filled with silica gel using a mixed solvent of methylene chloride and methyl alcohol as an elution solvent to give the target compound. (Yield: 90%-98%) The compounds of Examples 1 to 68 were synthesized through reaction formulas 1 to 13, and NMR data of each example compound are as follows. Representatively, the compound of <Example 1> was prepared by using a compound in which R1 is CF3, X is <semantics>N⋆<annotation encoding="application / x-tex">N_{\star}< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics> is methyl piperidine in [Reaction Formula 2] as a starting material in [Reaction Formula 12], and reacting with A-region. <semantics>⟨Example1⟩<annotation encoding="application / x-tex">\langle Example 1 \rangle< / annotation>< / semantics> (E) -3-(2-(4-methylpiperidin-1-yl) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 72%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (500 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.15 (s, 1H), 9.96 (s, 1H), 8.05 (d, J <semantics>20=7.65 Hz<annotation encoding="application / x-tex">20 = 7.65 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>). <semantics>7.70 (m<annotation encoding="application / x-tex">7.70 \text{ (m}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.59 (d, J=10.20 Hz<annotation encoding="application / x-tex">7.59 \text{ (d, J} = 10.20 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>7.42<annotation encoding="application / x-tex">7.42< / annotation>< / semantics> (d, <semantics>J=7.75<annotation encoding="application / x-tex">J = 7.75< / annotation>< / semantics> Hz, 1H), <semantics>7.24<annotation encoding="application / x-tex">7.24< / annotation>< / semantics> (d, <semantics>J=8.05<annotation encoding="application / x-tex">J = 8.05< / annotation>< / semantics> Hz, 1H), 6.93 (t, <semantics>J=7.90 Hz<annotation encoding="application / x-tex">J = 7.90 \text{ Hz}< / annotation>< / semantics>, 1H), 6.86 (d, <semantics>J=15.70 Hz<annotation encoding="application / x-tex">J = 15.70 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>6.78<annotation encoding="application / x-tex">6.78< / annotation>< / semantics> (d, <semantics>J=7.70<annotation encoding="application / x-tex">J = 7.70< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>4.20<annotation encoding="application / x-tex">4.20< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>3.63<annotation encoding="application / x-tex">3.63< / annotation>< / semantics> (d, <semantics>J=12.55 Hz,2H),2.86(t,J=12.15Hz,2H),1.96(m,T)<annotation encoding="application / x-tex">J = 12.55 \text{ Hz}, 2H), 2.86 (t, J = 12.15Hz, 2H), 1.96 (m, T)< / annotation>< / semantics> 1H), <semantics>1.72<annotation encoding="application / x-tex">1.72< / annotation>< / semantics> (d, <semantics>J=11.45<annotation encoding="application / x-tex">J = 11.45< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.31−<annotation encoding="application / x-tex">1.31-< / annotation>< / semantics> 5 1.26 (m, 2H), 1.25 (s, 4H), 0.95 (d, <semantics>J=6.45Hz<annotation encoding="application / x-tex">J = 6.45 Hz< / annotation>< / semantics>, 3H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 446 [M+H] + <semantics>⟨Example2⟩<annotation encoding="application / x-tex">\langle Example 2 \rangle< / annotation>< / semantics> (E) -3-(2-(4-ethylpiperidin-1-yl) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 10 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, Yield 88%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.09 (s, 1H), 9.88 (s, 1H), 8.01 (d, J <semantics>=7.6 Hz,1H),7.51 (d, J=15.6 Hz,1H),7.39 (d, J=15.6 Hz,1H),7.39 (d, J=15.6 Hz,1H),7.39 (d, J=15.6 Hz,1H),7.39 (d, J=15.6 Hz,1H),7.<annotation encoding="application / x-tex">= 7.6 \text{ Hz}, 1 \text{H}), 7.51 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.39 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.39 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.39 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.39 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.< / annotation>< / semantics> 15 8.0 Hz, 1H), 7.20 (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 8.0 Hz, 1H), 6.81 (d, <semantics>J=15.6<annotation encoding="application / x-tex">J = 15.6< / annotation>< / semantics> Hz, 1H), 6.74 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.2 Hz, 1H), 3.62 (d, <semantics>J=14.2<annotation encoding="application / x-tex">J = 14.2< / annotation>< / semantics> Hz, 2H), 2.81 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 11.6 Hz, 2H), 1.74 (d, <semantics>J=10.4<annotation encoding="application / x-tex">J = 10.4< / annotation>< / semantics> Hz, 2H), 1.27-1.19 (m, 4H), <semantics>1.15−1.13<annotation encoding="application / x-tex">1.15 - 1.13< / annotation>< / semantics> (t, <semantics>J=7.6<annotation encoding="application / x-tex">J = 7.6< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>0.84<annotation encoding="application / x-tex">0.84< / annotation>< / semantics> (m, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>); 20 Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 460 [M+H] + <Example <semantics>3><annotation encoding="application / x-tex">3>< / annotation>< / semantics> (E) <semantics>−N−(2−0xo−2,3−dihydro−1H−<annotation encoding="application / x-tex">-N-(2-0xo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-<semantics>4−y1<annotation encoding="application / x-tex">4-y1< / annotation>< / semantics>)-3-(2-(pyrrolidin-<semantics>1−y1<annotation encoding="application / x-tex">1-y1< / annotation>< / semantics>)-6- (trifluoromethyl)pyridin-3-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] 5 White solid, yield 65%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 10.08 (s, 1H), 9.08 (s, 1H), 7.83 (d, J <semantics>=7.2 Hz,1H),7.78 (d, J=15.6 Hz,1H),7.20 (d, J=15.6 Hz,1H),7.20 (d, J=15.6 Hz,1H),7.20 (d, J=15.6 Hz,1H),7.20 (d, J=15.6 Hz,1H),7.<annotation encoding="application / x-tex">= 7.2 \text{ Hz}, 1 \text{H}), 7.78 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.20 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.20 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.20 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.20 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.< / annotation>< / semantics> 8.0 Hz, 1H), 7.11 (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.88 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 8.0 Hz, 1H), 6.72 (d, <semantics>J=7.6<annotation encoding="application / x-tex">J = 7.6< / annotation>< / semantics> Hz, 1H), 6.50 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 15.2 Hz, 1H), 3.49 (m, 4H), 1.85 (m, 4H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 418 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics> * <Example <semantics>4><annotation encoding="application / x-tex">4>< / annotation>< / semantics> (E) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)-3-(2-(piperidin-1-yl)-6- (trifluoromethyl)pyridin-3-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 61%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (300MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.73 (s, 1H), 10.14 (s, 1H), 9.92 (s, 1H), 8.06 (d, J <semantics>=7.71 Hz<annotation encoding="application / x-tex">= 7.71 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.56 (d, J=15.39 Hz<annotation encoding="application / x-tex">7.56 \text{ (d, J} = 15.39 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.44 (d, J)<annotation encoding="application / x-tex">7.44 \text{ (d, J)}< / annotation>< / semantics> <semantics>=7.68 Hz,1H,7.23 (d, J=7.89 Hz,1H),6.95−6.84<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}, 7.23 \text{ (d, J} = 7.89 \text{ Hz}, 1\text{H}), 6.95-6.84< / annotation>< / semantics> <semantics>(m,2H),6.77(d,J=7.86Hz,1H),3.24(m,4H),1.66<annotation encoding="application / x-tex">(m, 2H), 6.77 (d, J = 7.86 Hz, 1H), 3.24 (m, 4H), 1.66< / annotation>< / semantics> <semantics>(m,8H)<annotation encoding="application / x-tex">(m, 8H)< / annotation>< / semantics>; Mass (ESI) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 432 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <Example 5> <semantics>(E)−3−(2−morpholino−6−<annotation encoding="application / x-tex">(E) -3 - (2-morpholino-6-< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] 6797.5 Yellow solid, yield 82%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (300MHz, CD30D) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.06 (d, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H), 7.84 (d, <semantics>J=15.8<annotation encoding="application / x-tex">J = 15.8< / annotation>< / semantics> Hz, 1H), 7.38 (d, <semantics>J=7.9 Hz<annotation encoding="application / x-tex">J = 7.9 \text{ Hz}< / annotation>< / semantics>, 1H), 7.05 (s, 1H), 7.04 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 2.4 Hz, 1H), 6.93 - 6.87 (m, 2H), 3.86 (m, 4H), 3.33 <semantics>(m,4H)<annotation encoding="application / x-tex">(m, 4H)< / annotation>< / semantics>; Mass (ESI) <semantics>m / z434[M+H]<annotation encoding="application / x-tex">m / z 434 [M+H]< / annotation>< / semantics> <Example <semantics>6>(E)−3−(2−(diethylamino)−6−<annotation encoding="application / x-tex">6 > (E) -3 - (2 - (diethylamino) -6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 80%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (500 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.12 (s, 1H), 9.90 (s, 1H), 7.99 (d, J <semantics>=7.60 Hz,1H),7.59 (d, J=15.55 Hz,1H),7.33 (d, J)<annotation encoding="application / x-tex">= 7.60 \text{ Hz}, 1\text{H}), 7.59 \text{ (d, J} = 15.55 \text{ Hz}, 1\text{H}), 7.33 \text{ (d, J)}< / annotation>< / semantics> <semantics>=7.75 Hz,1H,7.25 (d, J=8.10 Hz,1H),6.92 (t, J)<annotation encoding="application / x-tex">= 7.75 \text{ Hz}, 1\text{H}, 7.25 \text{ (d, J} = 8.10 \text{ Hz}, 1\text{H}), 6.92 \text{ (t, J)}< / annotation>< / semantics> <semantics>5=7.95 Hz<annotation encoding="application / x-tex">5 = 7.95 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.78 (d, J=11.76 Hz<annotation encoding="application / x-tex">6.78 \text{ (d, } J = 11.76 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.76 (s, <annotation encoding="application / x-tex">6.76 \text{ (s, }< / annotation>< / semantics> 1H), <semantics>2.94<annotation encoding="application / x-tex">2.94< / annotation>< / semantics> (m, <semantics>4H<annotation encoding="application / x-tex">4H< / annotation>< / semantics>) <semantics>1.14<annotation encoding="application / x-tex">1.14< / annotation>< / semantics> (t, <semantics>J=6.90<annotation encoding="application / x-tex">J = 6.90< / annotation>< / semantics> Hz, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>); Mass <semantics>(FAB)<annotation encoding="application / x-tex">(FAB)< / annotation>< / semantics> m / z 420 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics> + <Example 7> <semantics>(E)−3−(2−(dipropylamino)−6−<annotation encoding="application / x-tex">(E)-3-(2-(dipropylamino)-6-< / annotation>< / semantics> 10 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 82%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (500 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.10 (s, 1H), 9.91 (s, 1H), 7.97 (d, J <semantics>15=7.60 Hz,1H,7.59(d,J=15.55 Hz,1H),7.31(d,J)<annotation encoding="application / x-tex">15 = 7.60 \text{ Hz}, 1\text{H}, 7.59 (d, J = 15.55 \text{ Hz}, 1\text{H}), 7.31 (d, J)< / annotation>< / semantics> <semantics>=7.70 Hz,1H,7.25 (d, J=8.10 Hz,1H),6.93 (t, J)<annotation encoding="application / x-tex">= 7.70 \text{ Hz}, 1\text{H}, 7.25 \text{ (d, J} = 8.10 \text{ Hz}, 1\text{H}), 6.93 \text{ (t, J)}< / annotation>< / semantics> <semantics>=7.90 Hz<annotation encoding="application / x-tex">= 7.90 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.75−6.78 (dd, J=3.35 Hz<annotation encoding="application / x-tex">6.75-6.78 \text{ (dd, J} = 3.35 \text{ Hz}< / annotation>< / semantics>, <semantics>7.95 Hz<annotation encoding="application / x-tex">7.95 \text{ Hz}< / annotation>< / semantics>, 2H), 3.28 (t, <semantics>J=7.50 Hz<annotation encoding="application / x-tex">J = 7.50 \text{ Hz}< / annotation>< / semantics>, 4H), 1.60 (q, <semantics>J=7.25 Hz<annotation encoding="application / x-tex">J = 7.25 \text{ Hz}< / annotation>< / semantics>, 4H), 0.81 (t, <semantics>J=7.35<annotation encoding="application / x-tex">J = 7.35< / annotation>< / semantics> Hz, 6H); Mass (FAB) m / z 448 20 [M+H]+ <Example 8> [Image disponible dans le document PDF, Image available in the PDF document] (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 63%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.71 (s, 1H), 10.15 (s, 1H), 9.95 (s, 1H), 8.24 (d, J <semantics>=7.5 Hz,1H),7.71 (d, J=15.8 Hz,1H),7.57 (d, J=<annotation encoding="application / x-tex">= 7.5 \text{ Hz}, 1 \text{H}), 7.71 \text{ (d, J} = 15.8 \text{ Hz}, 1 \text{H}), 7.57 \text{ (d, J} =< / annotation>< / semantics> 7.9 Hz, 1H), 7.20 (d, <semantics>J=8.2<annotation encoding="application / x-tex">J = 8.2< / annotation>< / semantics> Hz, 1H), 7.05 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 15.8 Hz, 1H), 6.93 (t, <semantics>J=7.5<annotation encoding="application / x-tex">J = 7.5< / annotation>< / semantics> Hz, 1H), 6.78 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.7 Hz, 1H), 4.44 (t, <semantics>J=6.6<annotation encoding="application / x-tex">J = 6.6< / annotation>< / semantics> Hz, 2H), 1.81 (m, 2H), 1.46 (m, 2H), 0.96 (t, <semantics>J=7.32 Hz<annotation encoding="application / x-tex">J = 7.32 \text{ Hz}< / annotation>< / semantics>, 3H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 421 [M+H] + <Example 9> <semantics>(E)−3−(2−(hexyloxy)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (hexyloxy) -6 -< / annotation>< / semantics> 15 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 73%; <semantics>1H<annotation encoding="application / x-tex">^{1}\text{H}< / annotation>< / semantics> NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.71 (s, 1H), 10.15 (s, 1H), 9.95 (s, 1H), 8.24 (d, J <semantics>=7.71 Hz,1H,7.70 (d, J=15.75 Hz,1H),7.56 (d, J<annotation encoding="application / x-tex">= 7.71 \text{ Hz}, 1\text{H}, 7.70 \text{ (d, J} = 15.75 \text{ Hz}, 1\text{H}), 7.56 \text{ (d, J}< / annotation>< / semantics> <semantics>=7.68 Hz,1H),7.21 (d, J=8.25 Hz,1H),7.05 (d, J)<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}), 7.21 \text{ (d, J} = 8.25 \text{ Hz}, 1\text{H}), 7.05 \text{ (d, J)}< / annotation>< / semantics> <semantics>=15.75 Hz<annotation encoding="application / x-tex">= 15.75 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.93 (t, 1H)<annotation encoding="application / x-tex">6.93 \text{ (t, } 1\text{H)}< / annotation>< / semantics>, <semantics>6.77 (d, J=7.89 Hz<annotation encoding="application / x-tex">6.77 \text{ (d, } J = 7.89 \text{ Hz}< / annotation>< / semantics>, 1H), 4.43 (t, <semantics>J=6.57<annotation encoding="application / x-tex">J = 6.57< / annotation>< / semantics> Hz, 2H), 1.82 (m, 2H), 1.43- 1.23 <semantics>(m,7H),0.88−0.86(m,3H);Mass(FAB)m / z449<annotation encoding="application / x-tex">(m, 7H), 0.88-0.86 (m, 3H); Mass (FAB) m / z 449< / annotation>< / semantics> <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <Example 10> <semantics>(E)−3−(2−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobutoxy−6−isobuto<annotation encoding="application / x-tex">(E)-3-(2-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobutoxy-6-isobuto< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 73%; 1H NMR(300MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> <semantics>10.72<annotation encoding="application / x-tex">10.72< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>10.16<annotation encoding="application / x-tex">10.16< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.95<annotation encoding="application / x-tex">7.95< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>8.25<annotation encoding="application / x-tex">8.25< / annotation>< / semantics> (d, <semantics>J<annotation encoding="application / x-tex">J< / annotation>< / semantics> <semantics>=7.71 Hz<annotation encoding="application / x-tex">= 7.71 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.74 (d, J=15.75 Hz<annotation encoding="application / x-tex">7.74 \text{ (d, } J = 15.75 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.57 (d, J<annotation encoding="application / x-tex">7.57 \text{ (d, } J< / annotation>< / semantics> <semantics>=7.69 Hz,1H,7.19 (d, J=7.71 Hz,1H),7.04 (d, J<annotation encoding="application / x-tex">= 7.69 \text{ Hz}, 1\text{H}, 7.19 \text{ (d, } J = 7.71 \text{ Hz}, 1\text{H}), 7.04 \text{ (d, } J< / annotation>< / semantics> <semantics>=15.72 Hz,1H),6.93 (t, J=8.04 Hz,1H),6.78 (d, J<annotation encoding="application / x-tex">= 15.72 \text{ Hz}, 1\text{H}), 6.93 \text{ (t, } J = 8.04 \text{ Hz}, 1\text{H}), 6.78 \text{ (d, } J< / annotation>< / semantics> <semantics>=7.68 Hz,1H),4.21 (d, J=6.78 Hz,1H),2.17 (p, J<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}), 4.21 \text{ (d, } J = 6.78 \text{ Hz}, 1\text{H}), 2.17 \text{ (p, } J< / annotation>< / semantics> <semantics>=6.57 Hz,1H),1.02 (d, J=6.78 Hz,6H); Mass (ESI)<annotation encoding="application / x-tex">= 6.57 \text{ Hz}, 1 \text{H}), 1.02 \text{ (d, } J = 6.78 \text{ Hz}, 6 \text{H}); \text{ Mass (ESI)}< / annotation>< / semantics> <semantics>5 m / z 421 [M+H]+<annotation encoding="application / x-tex">5 \text{ m / z } 421 \text{ [M+H]}^+< / annotation>< / semantics> <Example <semantics>11><annotation encoding="application / x-tex">11>< / annotation>< / semantics> (E) -3-(2-cyclobutoxy-6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.71 (s, 1H), 10.14 (s, 1H), 9.98 (s, 1H), 8.23 (d, J <semantics>=7.7 Hz,1H),7.68 (d, J=15.6 Hz,1H),7.56 (d, J=15.6 Hz,1H),7.56 (d, J=15.6 Hz,1H),7.56 (d, J=15.6 Hz,1H),7.56 (d, J=15.6 Hz,1H),7.<annotation encoding="application / x-tex">= 7.7 \text{ Hz}, 1 \text{H}), 7.68 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.56 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.56 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.56 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.56 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.< / annotation>< / semantics> 7.5 Hz, 1H), 7.18 (d, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H), 7.09 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.5 Hz, 1H), 6.93 (t, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H), 6.78 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.9 Hz, 1H), 5.26 (m, 1H), 2.50 (m, 2H), 2.22 (m, 2H), 1.78 (m, 2H); Mass (ESI) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 419 [M+H]+ <Example 12> <semantics>(E)−3−(2−(cyclopentyloxy)−6−<annotation encoding="application / x-tex">(E)-3-(2-(cyclopentyloxy)-6-< / annotation>< / semantics> 20 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 62%; 1H-NMR (400 MHz, DMSO-D6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.09 (s, 1H), 9.90 (s, 1H), 8.18 (d, <semantics>J=7.8Hz<annotation encoding="application / x-tex">J = 7.8 Hz< / annotation>< / semantics>, 1H), 7.63 (d, <semantics>J=16.1Hz<annotation encoding="application / x-tex">J = 16.1 Hz< / annotation>< / semantics>, 1H), 7.50 (d, <semantics>J<annotation encoding="application / x-tex">J< / annotation>< / semantics> <semantics>=7.4 Hz,1H),7.13 (d, J=8.3 Hz,1H),6.99 (d, J=<annotation encoding="application / x-tex">= 7.4 \text{ Hz}, 1 \text{H}), 7.13 \text{ (d, J} = 8.3 \text{ Hz}, 1 \text{H}), 6.99 \text{ (d, J} =< / annotation>< / semantics> 16.1 Hz, 1H), 6.89 (t, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, 1H), 6.74 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.8 Hz, 1H), 5.45 (s, 1H), 2.01 (t, <semantics>J=6.4<annotation encoding="application / x-tex">J = 6.4< / annotation>< / semantics> Hz, 3H), 1.92 (s, 2H), <semantics>1.69−1.79<annotation encoding="application / x-tex">1.69-1.79< / annotation>< / semantics> (m, 4H), <semantics>1.59<annotation encoding="application / x-tex">1.59< / annotation>< / semantics> (d, <semantics>J=8.3<annotation encoding="application / x-tex">J = 8.3< / annotation>< / semantics> Hz, 3H); Mass (ESI) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 433 [M+H] + <semantics>⟨Example13⟩<annotation encoding="application / x-tex">\langle Example 13 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 82%; 1H NMR (600MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.14 (s, 1H), 9.95 (s, 1H), <semantics>8.24<annotation encoding="application / x-tex">8.24< / annotation>< / semantics> (d, <semantics>J=7.80<annotation encoding="application / x-tex">J = 7.80< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.73<annotation encoding="application / x-tex">7.73< / annotation>< / semantics> (d, <semantics>J=16.02<annotation encoding="application / x-tex">J = 16.02< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 7.57 (d, <semantics>J=7.38 Hz<annotation encoding="application / x-tex">J = 7.38 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 7.20 (d, <semantics>J=8.28 Hz<annotation encoding="application / x-tex">J = 8.28 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 7.07 (d, <semantics>J=16.02 Hz<annotation encoding="application / x-tex">J = 16.02 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.93<annotation encoding="application / x-tex">6.93< / annotation>< / semantics> (t, <semantics>J=8.28 Hz<annotation encoding="application / x-tex">J = 8.28 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.77<annotation encoding="application / x-tex">6.77< / annotation>< / semantics> (d, <semantics>J=7.80<annotation encoding="application / x-tex">J = 7.80< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>4.29<annotation encoding="application / x-tex">4.29< / annotation>< / semantics> (d, <semantics>J=6.84<annotation encoding="application / x-tex">J = 6.84< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), 1.35 (m, 1H), 0.60 (q, <semantics>J=6.42 Hz<annotation encoding="application / x-tex">J = 6.42 \text{ Hz}< / annotation>< / semantics>, 2H), 0.42 (q, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 5.04 Hz, 2H); Mass (ESI) m / z 419 [M+H] + <semantics>⟨Example<annotation encoding="application / x-tex">\langle \text{Example}< / annotation>< / semantics> 14<semantics>⟩<annotation encoding="application / x-tex">\rangle< / annotation>< / semantics> (E) <semantics>−N−(2−0xo−2,3−dihydro−1H−<annotation encoding="application / x-tex">-N-(2-0xo-2,3-dihydro-1H-< / annotation>< / semantics> benzo[d]imidazol-<semantics>4−y1<annotation encoding="application / x-tex">4-y1< / annotation>< / semantics>)-3-(2-(2,2,2-trifluoroethoxy)-6- (trifluoromethyl)pyridin-3-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 62%; 1H-NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.68 (s, 1H), 10.14 (s, 1H), 9.98 (s. 1H), 8.33 (d, <semantics>J=7.2 Hz<annotation encoding="application / x-tex">J = 7.2 \text{ Hz}< / annotation>< / semantics>, 1H), 7.69 (m, 2H), 7.14 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.6 Hz, 1H), 6.96 (d, <semantics>J=15.6<annotation encoding="application / x-tex">J = 15.6< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=15.6<annotation encoding="application / x-tex">J = 15.6< / annotation>< / semantics> Hz, 1H) 8.0 Hz, 1H), 6.74 (d, <semantics>J=8.8<annotation encoding="application / x-tex">J = 8.8< / annotation>< / semantics> Hz, 1H), 5.11(q, <semantics>J=8.8<annotation encoding="application / x-tex">J = 8.8< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 447 <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <semantics>⟨Example<annotation encoding="application / x-tex">\langle Example< / annotation>< / semantics> 15<semantics>⟩<annotation encoding="application / x-tex">\rangle< / annotation>< / semantics> (E) -3-(2-(neopentyloxy)-6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 52%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.68 (s, 1H), 10.13 (s, 1H), 9.91 (s. 1H), 8.22 (d, J <semantics>=7.6 Hz,1H),7.74 (d, J=16.0 Hz,1H),7.75 (d, J=16.0 Hz,1H),7.75 (d, J=16.0 Hz,1H),7.75 (d, J=16.0 Hz,1H),7.75 (d, J=16.0 Hz,1H<annotation encoding="application / x-tex">= 7.6 \text{ Hz}, 1 \text{H}), 7.74 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.75 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.75 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.75 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.75 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}< / annotation>< / semantics> 0.80 Hz, 1H), 7.15 (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 6.95 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 5 8.4 Hz, 1H), 6.88 (t, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.6 Hz, 1H), 4.60 (s, 2H), 1.02 (s, 9H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 435 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <Example 16> <semantics>(E)−3−(2−((2−<annotation encoding="application / x-tex">(E) -3 - (2 - ((2 -< / annotation>< / semantics> 10 methylcyclopropyl)methoxy)-6-(trifluoromethyl)pyridin- <semantics>3−y1)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−<annotation encoding="application / x-tex">3-y1)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-< / annotation>< / semantics> yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 63%; <semantics>1H−NMR<annotation encoding="application / x-tex">^{1}H-NMR< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 15 10.69 (s, 1H), 10.15 (s, 1H), 9.94 (s, 1H), 8.20 (d, J <semantics>=7.6 Hz,1H),7.72−7.66 (m, 1H),7.52 (d, J=8.0 Hz,<annotation encoding="application / x-tex">= 7.6 \text{ Hz}, 1\text{H}), 7.72-7.66 \text{ (m, 1H)}, 7.52 \text{ (d, J} = 8.0 \text{ Hz},< / annotation>< / semantics> 1H), <semantics>7.16<annotation encoding="application / x-tex">7.16< / annotation>< / semantics> (d, <semantics>J=7.6<annotation encoding="application / x-tex">J = 7.6< / annotation>< / semantics> Hz, 1H), <semantics>7.03<annotation encoding="application / x-tex">7.03< / annotation>< / semantics> (d, <semantics>J=16.0<annotation encoding="application / x-tex">J = 16.0< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, 1H), 6.74 (d, <semantics>J=7.2 Hz<annotation encoding="application / x-tex">J = 7.2 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>4.32−4.18<annotation encoding="application / x-tex">4.32-4.18< / annotation>< / semantics> (m, 2H), <semantics>0.99<annotation encoding="application / x-tex">0.99< / annotation>< / semantics> (d, <semantics>J=6.0<annotation encoding="application / x-tex">J = 6.0< / annotation>< / semantics> Hz, 3H), 20 0.81-0.80 (m, 2H), 0.54 (m, 1H), 0.32 (m, 1H); Mass <semantics>(FAB)m / z433[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 433 [M+H]^{+}< / annotation>< / semantics> <semantics>⟨Example17⟩(E)−3−(6−(chlorodifluoromethyl)−2−<annotation encoding="application / x-tex">\langle \text{Example} \quad 17 \rangle \quad (E) -3 - (6 - (\text{chlorodifluoromethyl}) -2 -< / annotation>< / semantics> (cyclopropylmethoxy)pyridin-3-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 71%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 10.23 (s, 1H), 10.02 (s, 1H), 8.20 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.68 (d, J=16.0 Hz<annotation encoding="application / x-tex">7.68 \text{ (d, } J = 16.0 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.46 (d, J<annotation encoding="application / x-tex">7.46 \text{ (d, } J< / annotation>< / semantics> <semantics>=7.6 Hz,1H),7.19(d,J=8.0 Hz,1H),7.05(d,J=8.0 Hz,1H),7.05(d,J=8.0 Hz,1H),7.05(d,J=8.0 Hz,1H),7.05(d,J=8.0 Hz,1H),7.05(d,J=8.0 Hz,1H),<annotation encoding="application / x-tex">= 7.6 \text{ Hz}, 1\text{H}), 7.19 (d, J = 8.0 \text{ Hz}, 1\text{H}), 7.05 (d, J = 8.0 \text{ Hz}, 1\text{H}), 7.05 (d, J = 8.0 \text{ Hz}, 1\text{H}), 7.05 (d, J = 8.0 \text{ Hz}, 1\text{H}), 7.05 (d, J = 8.0 \text{ Hz}, 1\text{H}), 7.05 (d, J = 8.0 \text{ Hz}, 1\text{H}),< / annotation>< / semantics> 16.0 Hz, 1H), 6.88 (t, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.6 Hz, 1H), 4.26 (d, <semantics>J=7.2<annotation encoding="application / x-tex">J = 7.2< / annotation>< / semantics> Hz, 2H), 1.33 (m, 1H), <semantics>0.55<annotation encoding="application / x-tex">0.55< / annotation>< / semantics> (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.38<annotation encoding="application / x-tex">0.38< / annotation>< / semantics> (d, <semantics>J=5.2<annotation encoding="application / x-tex">J = 5.2< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass (ESI) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 435 <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <Example 18> <semantics>(E)−3−(6−cyclopropyl−2−<annotation encoding="application / x-tex">(E)-3-(6-cyclopropyl-2-< / annotation>< / semantics> (cyclopropylmethoxy)pyridin-3-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.09 (s, 1H), 9.75 (s, 1H), 7.80 (d, J <semantics>=7.8 Hz,1H),7.64 (d, J=16.0 Hz,1H),7.19 (t, J=16.0 Hz,1H),7.19 (t, J=16.0 Hz,1H),7.19 (t, J=16.0 Hz,1H),7.19 (t, J=16.0 Hz,1H<annotation encoding="application / x-tex">= 7.8 \text{ Hz}, 1 \text{H}), 7.64 \text{ (d, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.19 \text{ (t, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.19 \text{ (t, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.19 \text{ (t, } J = 16.0 \text{ Hz}, 1 \text{H}), 7.19 \text{ (t, } J = 16.0 \text{ Hz}, 1 \text{H}< / annotation>< / semantics> 8.0 Hz, 1H), 6.96 (d, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, 1H), 6.79-6.90 (m, 2H), 6.71 (d, <semantics>J=7.3 Hz<annotation encoding="application / x-tex">J = 7.3 \text{ Hz}< / annotation>< / semantics>, 1H), 4.14 (d, <semantics>J=6.9 Hz<annotation encoding="application / x-tex">J = 6.9 \text{ Hz}< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.99−2.05<annotation encoding="application / x-tex">1.99-2.05< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>0.93<annotation encoding="application / x-tex">0.93< / annotation>< / semantics> (d, <semantics>J=6.4<annotation encoding="application / x-tex">J = 6.4< / annotation>< / semantics> Hz, <semantics>4H<annotation encoding="application / x-tex">4H< / annotation>< / semantics>), <semantics>0.81<annotation encoding="application / x-tex">0.81< / annotation>< / semantics> <semantics>(t,J=6.9Hz,1H),0.53(d,J=6.9Hz,2H),0.31<annotation encoding="application / x-tex">(t, J = 6.9 Hz, 1H), 0.53 (d, J = 6.9 Hz, 2H), 0.31< / annotation>< / semantics> <semantics>(d,J=4.6Hz,2H);Mass(FAB)m / z391[M+H]+<annotation encoding="application / x-tex">(d, J = 4.6 Hz, 2H); Mass (FAB) m / z 391 [M+H] +< / annotation>< / semantics> <semantics>⟨Example19⟩<annotation encoding="application / x-tex">\langle Example 19 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -6- isopropylpyridin-3-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 52%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 10.10 (s, 1H), 9.77 (s, 1H), 7.87 (d, J <semantics>=7.6 Hz,1H),7.67 (d, J=16.0 Hz,1H),7.20 (d, J=16.0 Hz,1H)<annotation encoding="application / x-tex">= 7.6 \text{ Hz}, 1 \text{H}), 7.67 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.20 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H})< / annotation>< / semantics> 8.0 Hz, 1H), <semantics>6.92−6.83<annotation encoding="application / x-tex">6.92-6.83< / annotation>< / semantics> (m, 3H), <semantics>6.72<annotation encoding="application / x-tex">6.72< / annotation>< / semantics> (d, J = <semantics>7.2<annotation encoding="application / x-tex">7.2< / annotation>< / semantics> Hz, 1H), 4.23 (d, <semantics>J=6.8<annotation encoding="application / x-tex">J = 6.8< / annotation>< / semantics> Hz, 2H), 2.94-2.87 (m, 1H), <semantics>1.36−1.27<annotation encoding="application / x-tex">1.36-1.27< / annotation>< / semantics> (m, 1H), <semantics>1.19<annotation encoding="application / x-tex">1.19< / annotation>< / semantics> (d, <semantics>J=6.8<annotation encoding="application / x-tex">J = 6.8< / annotation>< / semantics> Hz, 6H), <semantics>0.56−0.51<annotation encoding="application / x-tex">0.56-0.51< / annotation>< / semantics> <semantics>(m,2H),0.35−0.33(m,2H);Mass(FAB)m / z393[M+H]+<annotation encoding="application / x-tex">(m, 2H), 0.35-0.33 (m, 2H); Mass (FAB) m / z 393 [M+H] +< / annotation>< / semantics> <semantics>⟨Example20⟩<annotation encoding="application / x-tex">\langle Example 20 \rangle< / annotation>< / semantics> (E)-3-(2-(cyclopropylmethoxy)-6-(1- methylcyclopropyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 61%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.65 (s, 1H), 10.23(s, 1H), 9.87 (s, 1H), 7.86 (d, J <semantics>=8.4 Hz,1H),7.65 (d, J=16.0 Hz,1H),7.23 (d, J=16.0 Hz,1H),7.23 (d, J=16.0 Hz,1H),7.23 (d, J=16.0 Hz,1H),7.23 (d, J=16.0 Hz,1H),7.<annotation encoding="application / x-tex">= 8.4 \text{ Hz}, 1 \text{H}), 7.65 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.23 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.23 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.23 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.23 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.< / annotation>< / semantics> 8.0 Hz, 1H), 6.98 (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.89-6.84 (m, 2H), 6.70 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, 1H), 4.13 (d, <semantics>J=6.8 Hz<annotation encoding="application / x-tex">J = 6.8 \text{ Hz}< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.42<annotation encoding="application / x-tex">1.42< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.27−1.25<annotation encoding="application / x-tex">1.27-1.25< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.18−1.17<annotation encoding="application / x-tex">1.18-1.17< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.81−0.78<annotation encoding="application / x-tex">0.81-0.78< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.55−0.52<annotation encoding="application / x-tex">0.55-0.52< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.32−0.31<annotation encoding="application / x-tex">0.32-0.31< / annotation>< / semantics> <semantics>(m,2H)<annotation encoding="application / x-tex">(m, 2H)< / annotation>< / semantics>; Mass (FAB) <semantics>m / z405[M+H]<annotation encoding="application / x-tex">m / z 405 [M+H]< / annotation>< / semantics>+ <semantics>⟨Example21⟩<annotation encoding="application / x-tex">\langle Example 21 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -6- (difluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 70%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (DMSO, 400 MHz) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.68 (s, 1H), 10.21(s, 1H), 9.97 (s, 1H), 8.14 (d, J <semantics>=7.2 Hz,1H),7.69 (d, J=16.0 Hz,1H),7.32 (d, J=16.0 Hz,1H),7.32 (d, J=16.0 Hz,1H),7.32 (d, J=16.0 Hz,1H),7.32 (d, J=16.0 Hz,1H),7.<annotation encoding="application / x-tex">= 7.2 \text{ Hz}, 1 \text{H}), 7.69 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.32 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.32 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.32 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.32 \text{ (d, J} = 16.0 \text{ Hz}, 1 \text{H}), 7.< / annotation>< / semantics> 7.2 Hz, 1H), 7.18 (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics>Hz, 1H), 7.02-6.72 (m, 5 4H), 4.23 (d, <semantics>J=6.8<annotation encoding="application / x-tex">J = 6.8< / annotation>< / semantics> Hz, 2H), 1.33-1.28 (m, 1H), <semantics>0.57−0.53<annotation encoding="application / x-tex">0.57-0.53< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.38−0.34<annotation encoding="application / x-tex">0.38-0.34< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass (FAB) m / z <semantics>401[M+H]+<annotation encoding="application / x-tex">401 [M+H]^{+}< / annotation>< / semantics> <semantics>⟨Example22⟩<annotation encoding="application / x-tex">\langle Example 22 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -6- 10 (1,1-difluoroethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 59%; 1H NMR (DMSO, 400 MHz) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 10.20(s, 1H), 9.97 (s, 1H), 8.12 (d, J <semantics>15=8.0 Hz,1H),7.69(d,J=16.0 Hz,1H),7.32(d,J=16.0 Hz,1H),7.32(d,J=16.0 Hz,1H),7.32(d,J=16.0 Hz,1H),7.32(d,J=16.0 Hz,1H),7.32(d,J=16.0 Hz,<annotation encoding="application / x-tex">15 = 8.0 \text{ Hz}, 1\text{H}), 7.69 (d, J = 16.0 \text{ Hz}, 1\text{H}), 7.32 (d, J = 16.0 \text{ Hz}, 1\text{H}), 7.32 (d, J = 16.0 \text{ Hz}, 1\text{H}), 7.32 (d, J = 16.0 \text{ Hz}, 1\text{H}), 7.32 (d, J = 16.0 \text{ Hz}, 1\text{H}), 7.32 (d, J = 16.0 \text{ Hz},< / annotation>< / semantics> 7.6 Hz, 1H), 7.19 (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics>Hz, 1H), 6.99 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 16.0 Hz, 1H), 6.89 (t, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.6 Hz, 1H), 4.25 (d, <semantics>J=6.8<annotation encoding="application / x-tex">J = 6.8< / annotation>< / semantics> Hz, 2H), 1.95 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 18.8 Hz, 3H), <semantics>1.35−1.30<annotation encoding="application / x-tex">1.35-1.30< / annotation>< / semantics> (m, 1H), <semantics>0.58−0.53<annotation encoding="application / x-tex">0.58-0.53< / annotation>< / semantics> (m, 2H), 20 0.38-0.35 (m, 2H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 415 [M+H]+ <Example 23> <semantics>(E)−3−(6−(tert−buty1)−2−<annotation encoding="application / x-tex">(E) -3 - (6 - (tert-buty1) -2 -< / annotation>< / semantics> (cyclopropylmethoxy)pyridin-3-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 59%; 1H NMR (DMSO, 400 MHz) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.17(s, 1H), 9.84 (s, 1H), 7.88 (d, J <semantics>=8.0 Hz,1H),7.66 (d, J=15.6 Hz,1H),7.21 (d, J=15.6 Hz,1H)<annotation encoding="application / x-tex">= 8.0 \text{ Hz}, 1 \text{H}), 7.66 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H}), 7.21 \text{ (d, J} = 15.6 \text{ Hz}, 1 \text{H})< / annotation>< / semantics> 8.0 Hz, 1H), 7.02 (d, <semantics>J=7.6<annotation encoding="application / x-tex">J = 7.6< / annotation>< / semantics> Hz, 1H), 6.89-6.85 (m, 2H), 6.71 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, 1H), 4.23 (d, <semantics>J=6.8 Hz<annotation encoding="application / x-tex">J = 6.8 \text{ Hz}< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.36−1.30<annotation encoding="application / x-tex">1.36-1.30< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.26<annotation encoding="application / x-tex">1.26< / annotation>< / semantics> (s, <semantics>9H<annotation encoding="application / x-tex">9H< / annotation>< / semantics>), <semantics>0.56−0.51<annotation encoding="application / x-tex">0.56-0.51< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.35−0.33<annotation encoding="application / x-tex">0.35-0.33< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass (FAB) m / z <semantics>407<annotation encoding="application / x-tex">407< / annotation>< / semantics> [M+H] <semantics>+<annotation encoding="application / x-tex">^{+}< / annotation>< / semantics> <semantics>⟨Example 24⟩<annotation encoding="application / x-tex">\langle \text{Example } 24 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -6-(2- hydroxypropan-2-yl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 63%; 1H NMR (DMSO, 400 MHz) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.65 (s, 1H), 10.33(s, 1H), 9.98 (s, 1H), 7.95 (d, <semantics>J=7.6Hz<annotation encoding="application / x-tex">J=7.6 Hz< / annotation>< / semantics>, 1H), 7.68 (d, <semantics>J=16.0Hz<annotation encoding="application / x-tex">J=16.0 Hz< / annotation>< / semantics>, 1H), 7.25 (d, <semantics>J=7.6<annotation encoding="application / x-tex">J=7.6< / annotation>< / semantics> Hz, 1H), <semantics>6.93−6.86<annotation encoding="application / x-tex">6.93-6.86< / annotation>< / semantics> (m, 2H), <semantics>6.71<annotation encoding="application / x-tex">6.71< / annotation>< / semantics> (d, <semantics>J=7.6<annotation encoding="application / x-tex">J=7.6< / annotation>< / semantics> Hz), <semantics>5.12<annotation encoding="application / x-tex">5.12< / annotation>< / semantics> <semantics>(s,1H),4.22(d,J=7.2Hz,2H),1.39(s,6H),1.34−<annotation encoding="application / x-tex">(s, 1H), 4.22 (d, J=7.2 Hz, 2H), 1.39 (s, 6H), 1.34-< / annotation>< / semantics> 1.27 <semantics>(m,1H),0.56−0.51(m,2H),0.36−0.32(m,2H);<annotation encoding="application / x-tex">(m, 1H), 0.56-0.51 (m, 2H), 0.36-0.32 (m, 2H);< / annotation>< / semantics> 5 Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 409 [M+H]+ <semantics>⟨Example25⟩<annotation encoding="application / x-tex">\langle Example 25 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclobutylmethoxy) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] . Yellow solid, yield 83%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.10 (s, 1H), 9.91 (s, 1H), 7.97 (d, J <semantics>=7.60 Hz<annotation encoding="application / x-tex">= 7.60 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.69 (d, J=15.36 Hz<annotation encoding="application / x-tex">7.69 \text{ (d, J} = 15.36 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.55 (d, J)<annotation encoding="application / x-tex">7.55 \text{ (d, J)}< / annotation>< / semantics> <semantics>=7.68 Hz,1H,7.15 (d, J=7.95 Hz,1H,7.01 (d, J)<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}, 7.15 \text{ (d, J} = 7.95 \text{ Hz}, 1\text{H}, 7.01 \text{ (d, J)}< / annotation>< / semantics> <semantics>=15.93 Hz<annotation encoding="application / x-tex">= 15.93 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1 \text{H}< / annotation>< / semantics>), <semantics>6.92 (m, 1H)<annotation encoding="application / x-tex">6.92 \text{ (m, } 1 \text{H)}< / annotation>< / semantics>, <semantics>6.78 (d, J=7.95 Hz<annotation encoding="application / x-tex">6.78 \text{ (d, } J = 7.95 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>4.40<annotation encoding="application / x-tex">4.40< / annotation>< / semantics> (d, <semantics>J=6.96<annotation encoding="application / x-tex">J = 6.96< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>2.01<annotation encoding="application / x-tex">2.01< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.89<annotation encoding="application / x-tex">1.89< / annotation>< / semantics> (m, 3H), 1.21 (m, 2H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 433 [M+H]+ <Example 26> <semantics>(E)−3−(2−(cyclopentylmethoxy)−6−<annotation encoding="application / x-tex">(E)-3-(2-(cyclopentylmethoxy)-6-< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 63%; <semantics>1H<annotation encoding="application / x-tex">^{1}\text{H}< / annotation>< / semantics> NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.16 (s, 1H), 9.94(s, 1H), 8.24 (d, J <semantics>=7.71 Hz,1H),7.72 (d, J=15.75 Hz,1H),7.57 (d, J<annotation encoding="application / x-tex">= 7.71 \text{ Hz}, 1 \text{H}), 7.72 \text{ (d, } J = 15.75 \text{ Hz}, 1 \text{H}), 7.57 \text{ (d, } J< / annotation>< / semantics> <semantics>=7.68 Hz,1H),7.19 (d, J=7.89 Hz,1H),7.04 (d, J<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}), 7.19 \text{ (d, J} = 7.89 \text{ Hz}, 1\text{H}), 7.04 \text{ (d, J}< / annotation>< / semantics> <semantics>=15.75 Hz,1H),6.93(t,J=7.86 Hz,1H),6.78(d,J)<annotation encoding="application / x-tex">= 15.75 \text{ Hz}, 1\text{H}), 6.93 (t, J = 7.86 \text{ Hz}, 1\text{H}), 6.78 (d, J)< / annotation>< / semantics> <semantics>=7.71 Hz,1H),4.31 (d, J=7.14 Hz,2H),2.46 (m, <annotation encoding="application / x-tex">= 7.71 \text{ Hz}, 1\text{H}), 4.31 \text{ (d, } J = 7.14 \text{ Hz}, 2\text{H}), 2.46 \text{ (m, }< / annotation>< / semantics> 1H), 1.80 (m, 2H), 1.61 (m, 4H), 1.37 (m, 2H); Mass <semantics>(FAB)m / z447[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 447 [M+H]^+< / annotation>< / semantics> <Example 27> <semantics>(E)−3−(2−(isobutylthio)−6−<annotation encoding="application / x-tex">(E)-3-(2-(isobutylthio)-6-< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 55%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.73 (s, 1H), 10.22 (s, 1H), 10.08 (s, 1H), 8.15 (d, <semantics>J=8.43 Hz,1H),7.22(d,J=8.43 Hz,1H),7.73(d,J)<annotation encoding="application / x-tex">J = 8.43 \text{ Hz}, 1\text{H}), 7.22 (d, J = 8.43 \text{ Hz}, 1\text{H}), 7.73 (d, J)< / annotation>< / semantics> <semantics>J=16.11 Hz,1H),7.71 (m,1H),6.96 (d, J=15.93 Hz,<annotation encoding="application / x-tex">J = 16.11 \text{ Hz}, 1H), 7.71 \text{ (m,1H)}, 6.96 \text{ (d, } J = 15.93 \text{ Hz},< / annotation>< / semantics> 1H), <semantics>6.92<annotation encoding="application / x-tex">6.92< / annotation>< / semantics> (d,J = <semantics>7.89<annotation encoding="application / x-tex">7.89< / annotation>< / semantics> Hz, 1H), <semantics>6.78<annotation encoding="application / x-tex">6.78< / annotation>< / semantics> (d, J = <semantics>7.86<annotation encoding="application / x-tex">7.86< / annotation>< / semantics> Hz, 1H), <semantics>3.17<annotation encoding="application / x-tex">3.17< / annotation>< / semantics> (d, <semantics>J=6.24<annotation encoding="application / x-tex">J = 6.24< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.94<annotation encoding="application / x-tex">1.94< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.00<annotation encoding="application / x-tex">1.00< / annotation>< / semantics> (d, <semantics>J=6.42 Hz<annotation encoding="application / x-tex">J = 6.42 \text{ Hz}< / annotation>< / semantics>, 6H); Mass (FAB) m / z 437 [M+H]+ 5 <semantics>⟨Example 28⟩<annotation encoding="application / x-tex">\langle \text{Example } 28 \rangle< / annotation>< / semantics> (E) -3-(2-((cyclopropylmethyl)thio) - 6-(trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 55%; 1H NMR (400 MHz, DMSO) 10 <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics>10.67 (s, 1H), 10.11 (s, 1H), 9.98 (s, 1H), 8.14 (d, <semantics>J=7.88 Hz,1H),7.70 (d, J=7.88 Hz,1H),7.72 (d, <annotation encoding="application / x-tex">J = 7.88 \text{ Hz}, 1\text{H}), 7.70 \text{ (d, } J = 7.88 \text{ Hz}, 1\text{H}), 7.72 \text{ (d, }< / annotation>< / semantics> <semantics>J=15.56 Hz,1H),7.22(d,J=8.12 Hz,1H),6.94(d,J)<annotation encoding="application / x-tex">J = 15.56 \text{ Hz}, 1\text{H}), 7.22 (d, J = 8.12 \text{ Hz}, 1\text{H}), 6.94 (d, J)< / annotation>< / semantics> <semantics>J=8.24 Hz,1H),6.62(d,J=7.64 Hz,1H),6.78(d,J)<annotation encoding="application / x-tex">J = 8.24 \text{ Hz}, 1\text{H}), 6.62 (d, J = 7.64 \text{ Hz}, 1\text{H}), 6.78 (d, J)< / annotation>< / semantics> <semantics>J=7.68 Hz,1H),6.93(d,J=15.88 Hz,1H),3.21(d,J)<annotation encoding="application / x-tex">J = 7.68 \text{ Hz}, 1\text{H}), 6.93 (d, J = 15.88 \text{ Hz}, 1\text{H}), 3.21 (d, J)< / annotation>< / semantics> <semantics>15J=7.20Hz,2H),1.16(m,1H),0.55(m,2H),0.3469<annotation encoding="application / x-tex">15 J = 7.20 Hz, 2H), 1.16 (m, 1H), 0.55 (m, 2H), 0.3469< / annotation>< / semantics> <semantics>(m,2H)<annotation encoding="application / x-tex">(m, 2H)< / annotation>< / semantics>; Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 435 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <Example 29> <semantics>(E)−3−(2−(cyclohexylthio)−6−<annotation encoding="application / x-tex">(E)-3-(2-(cyclohexylthio)-6-< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 20 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 59%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.19 (s,1H), 10.04 (s,1H), 8.14 (d, J <semantics>=8.07 Hz,1H),7.70 (d, J=8.04 Hz,1H),7.67 (d, J)<annotation encoding="application / x-tex">= 8.07 \text{ Hz}, 1\text{H}), 7.70 \text{ (d, J} = 8.04 \text{ Hz}, 1\text{H}), 7.67 \text{ (d, J)}< / annotation>< / semantics> <semantics>=15.36 Hz<annotation encoding="application / x-tex">= 15.36 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.22 (d, J=8.07 Hz<annotation encoding="application / x-tex">7.22 \text{ (d, J} = 8.07 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.94 (d, J)<annotation encoding="application / x-tex">6.94 \text{ (d, J)}< / annotation>< / semantics> <semantics>=7.32 Hz<annotation encoding="application / x-tex">= 7.32 \text{ Hz}< / annotation>< / semantics>, 1H), 6.93 (d, J = 15.75 Hz, 1H), 6.78 (d, J <semantics>=7.68 Hz,1H,3.91(m,1H),2.03(m,2H),1.72(m,2H),<annotation encoding="application / x-tex">= 7.68 \text{ Hz}, 1\text{H}, 3.91 (m, 1\text{H}), 2.03 (m, 2\text{H}), 1.72 (m, 2\text{H}),< / annotation>< / semantics> 1.51 <semantics>(m,6H)<annotation encoding="application / x-tex">(m, 6H)< / annotation>< / semantics>; Mass <semantics>(FAB)<annotation encoding="application / x-tex">(FAB)< / annotation>< / semantics> <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 463 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ 10 <semantics>⟨Example<annotation encoding="application / x-tex">\langle Example< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 75%; 1H NMR (400MHz, DMSO) 15 <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics>10.72 (s, 1H), 10.13 (s, 1H), 9.99 (s, 1H), 8.45 (d, <semantics>J=8.43 Hz,1H),8.07(d,J=8.58 Hz,1H),7.55(m,J)<annotation encoding="application / x-tex">J = 8.43 \text{ Hz}, 1\text{H}), 8.07 (d, J = 8.58 \text{ Hz}, 1\text{H}), 7.55 (m, J)< / annotation>< / semantics> 2H), 7.43 (m, 3H), 7.20 (d, <semantics>J=8.25 Hz<annotation encoding="application / x-tex">J = 8.25 \text{ Hz}< / annotation>< / semantics>, 1H), 6.93 (m, 2H), 6.76 (d, <semantics>J=7.86 Hz<annotation encoding="application / x-tex">J = 7.86 \text{ Hz}< / annotation>< / semantics>, 1H); Mass (FAB) m / z 443 [M+H] + <Example <semantics>31><annotation encoding="application / x-tex">31>< / annotation>< / semantics> (E) -3-(2-(3-chlorophenyl) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 62%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.11 (s, 1H), 9.98 (s, 1H), 8.45 (d, J <semantics>=8.2 Hz,1H),8.07 (d, J=8.3 Hz,1H),7.51−7.65 (m, <annotation encoding="application / x-tex">= 8.2 \text{ Hz}, 1 \text{H}), 8.07 \text{ (d, } J = 8.3 \text{ Hz}, 1 \text{H}), 7.51-7.65 \text{ (m, }< / annotation>< / semantics> 5H), 7.20 (d, <semantics>J=8.3 Hz<annotation encoding="application / x-tex">J = 8.3 \text{ Hz}< / annotation>< / semantics>, 1H), 6.89-6.98 (m, 2), 6.71 <semantics>(d,J=7.50 Hz,1H); Mass (ESI) m / z 459 [M+H]+<annotation encoding="application / x-tex">(d, J = 7.50 \text{ Hz}, 1\text{H}); \text{ Mass (ESI) m / z } 459 \text{ [M+H]}^{+}< / annotation>< / semantics> <semantics>⟨Example32⟩(E)−3−(2−(3−isopropylphenyl)−6−(2−isopropylphenyl)−6−(2−isopropylphenyl)−6−(3−isopropylphenyl)−6−(3−isopropylphenyl)−6−(3−isopropylphenyl)−6−(3−isopropylpheny<annotation encoding="application / x-tex">\langle Example \qquad 32 \rangle \qquad (E) -3 - (2 - (3 - isopropylphenyl) - 6 - (2 - isopropylphenyl) - 6 - (2 - isopropylphenyl) - 6 - (3 - isopropylphenyl) - 6 - (3 - isopropylphenyl) - 6 - (3 - isopropylphenyl) - 6 - (3 - isopropylpheny< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.71 (s, 1H), 10.05 (s, 1H), 9.95 (s, 1H), 8.42 (d, J <semantics>=7.7 Hz,1H),8.02(d,J=8.1 Hz,1H),7.59(d,J=8.1 Hz,1H),7.59(d,J=8.1 Hz,1H)<annotation encoding="application / x-tex">= 7.7 \text{ Hz}, 1 \text{H}), 8.02 (d, J = 8.1 \text{ Hz}, 1 \text{H}), 7.59 (d, J = 8.1 \text{ Hz}, 1 \text{H}), 7.59 (d, J = 8.1 \text{ Hz}, 1 \text{H})< / annotation>< / semantics> 15.8 Hz, 1H), <semantics>7.39−7.51<annotation encoding="application / x-tex">7.39-7.51< / annotation>< / semantics> (m, 4H), <semantics>7.20<annotation encoding="application / x-tex">7.20< / annotation>< / semantics> (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), <semantics>6.89−6.97<annotation encoding="application / x-tex">6.89-6.97< / annotation>< / semantics> (m, 2H), <semantics>6.76<annotation encoding="application / x-tex">6.76< / annotation>< / semantics> (d, <semantics>J=7.7<annotation encoding="application / x-tex">J = 7.7< / annotation>< / semantics> Hz, 1H), <semantics>2.98<annotation encoding="application / x-tex">2.98< / annotation>< / semantics> <semantics>(m,1H),1.24(d,J=6.8Hz,6H);Mass(FAB)m / z467<annotation encoding="application / x-tex">(m, 1H), 1.24 (d, J = 6.8 Hz, 6H); Mass (FAB) m / z 467< / annotation>< / semantics> <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <semantics>⟨Example 33⟩<annotation encoding="application / x-tex">\langle \text{Example } 33 \rangle< / annotation>< / semantics> (E) <semantics>−3−(2−(3−chloro−4−fluorophenyl)−(3−chloro−4−fluorophenyl)<annotation encoding="application / x-tex">-3 - (2 - (3 - \text{chloro} - 4 - \text{fluorophenyl}) - (3 - \text{chloro} - 4 - \text{fluorophenyl})< / annotation>< / semantics> 6-(trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.72 (s, 1H), 10.10 (s, 1H), 9.98 (s, 1H), 8.44 (d, J <semantics>=6.1 Hz,1H),8.07 (d, J=8.2 Hz,1H),7.81 (dd, J<annotation encoding="application / x-tex">= 6.1 \text{ Hz}, 1 \text{H}), 8.07 \text{ (d, J} = 8.2 \text{ Hz}, 1 \text{H}), 7.81 \text{ (dd, J}< / annotation>< / semantics> <semantics>=1.8<annotation encoding="application / x-tex">=1.8< / annotation>< / semantics>, <semantics>7.1<annotation encoding="application / x-tex">7.1< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.59−7.66<annotation encoding="application / x-tex">7.59-7.66< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>7.53<annotation encoding="application / x-tex">7.53< / annotation>< / semantics> (d, <semantics>J<annotation encoding="application / x-tex">J< / annotation>< / semantics> = 15.4 Hz, 1H), 7.21 (d, <semantics>J=8.3<annotation encoding="application / x-tex">J = 8.3< / annotation>< / semantics> Hz, 1H), .6.89-6.97 (m, 2H), 6.77 (d, <semantics>J=7.50<annotation encoding="application / x-tex">J = 7.50< / annotation>< / semantics> Hz, 1H); Mass (FAB) m / z 477 <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <Example 34> <semantics>(E)−3−(2−(4−fluorophenyl)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (4 - fluorophenyl) -6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 69%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.71 (s, 1H), 10.13 (s, 1H), 10.00 (s, 1H), 8.41 (d, <semantics>J=8.07Hz<annotation encoding="application / x-tex">J = 8.07 Hz< / annotation>< / semantics>, 1H), 8.01 (d, <semantics>J=8.25Hz<annotation encoding="application / x-tex">J = 8.25 Hz< / annotation>< / semantics>, 1H), 7.63 (m, 2H), <semantics>7.53<annotation encoding="application / x-tex">7.53< / annotation>< / semantics> (d, <semantics>J=15.54<annotation encoding="application / x-tex">J = 15.54< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.39<annotation encoding="application / x-tex">7.39< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>7.20<annotation encoding="application / x-tex">7.20< / annotation>< / semantics> <semantics>(d,J=8.22Hz,1H),6.93(m,2H),6.75(d,J=7.68)<annotation encoding="application / x-tex">(d, J = 8.22 Hz, 1H), 6.93 (m, 2H), 6.75 (d, J = 7.68)< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 443 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <semantics>⟨Example35⟩(E)−N−(2−oxo−2,3−dihydro−1H−<annotation encoding="application / x-tex">\langle Example \qquad 35 \rangle \qquad (E) -N - (2-oxo-2, 3-dihydro-1H-< / annotation>< / semantics> 10 benzo[d]imidazol-4-yl)-3-(2-(thiophen-2-yl)-6- (trifluoromethyl)pyridin-3-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 71%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.14 (s, 1H), 10.01 (s, 1H), 8.27 (d, 15 <semantics>J=7.8 Hz<annotation encoding="application / x-tex">J = 7.8 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>7.83−7.91<annotation encoding="application / x-tex">7.83-7.91< / annotation>< / semantics> (m, 3H), <semantics>7.48−7.48<annotation encoding="application / x-tex">7.48-7.48< / annotation>< / semantics> (m, 1H), 7.25 (dd, <semantics>J=5.3<annotation encoding="application / x-tex">J = 5.3< / annotation>< / semantics>, 3.9 Hz, 1H), 7.17 (d, <semantics>J=8.3<annotation encoding="application / x-tex">J = 8.3< / annotation>< / semantics> Hz, 1H), <semantics>6.85−6.92<annotation encoding="application / x-tex">6.85-6.92< / annotation>< / semantics> (m, 2H), <semantics>6.75<annotation encoding="application / x-tex">6.75< / annotation>< / semantics> (d, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, 1H); Mass <semantics>(FAB)m / z431[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 431 [M+H]^+< / annotation>< / semantics> <Example 36> <semantics>(E)−3−(2−(furan−2−y1)−6−<annotation encoding="application / x-tex">(E) -3 - (2 - (furan - 2 - y1) - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 61%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.12 (s, 1H), 9.97 (s, 1H), <semantics>8.29<annotation encoding="application / x-tex">8.29< / annotation>< / semantics> (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>8.00−8.07<annotation encoding="application / x-tex">8.00-8.07< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>7.89<annotation encoding="application / x-tex">7.89< / annotation>< / semantics> (d, <semantics>J=8.2Hz<annotation encoding="application / x-tex">J = 8.2 Hz< / annotation>< / semantics>, 1H), 7.19 (d, <semantics>J=8.2Hz<annotation encoding="application / x-tex">J = 8.2 Hz< / annotation>< / semantics>, 1H), 7.08 (d, <semantics>J<annotation encoding="application / x-tex">J< / annotation>< / semantics> <semantics>=3.7 Hz,1H),6.83−6.92 (m, 2H),6.73−6.76 (m, 2H);<annotation encoding="application / x-tex">= 3.7 \text{ Hz}, 1 \text{H}), 6.83-6.92 \text{ (m, 2H)}, 6.73-6.76 \text{ (m, 2H)};< / annotation>< / semantics> Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 415 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <Example <semantics>37>(E)−3−(2−(oxazol−2−y1)−6−<annotation encoding="application / x-tex">37 > (E) -3 - (2 - (oxazol - 2 - y1) - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 58%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.12 (s, 1H), 9.97 (s, 1H), 8.29 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.75<annotation encoding="application / x-tex">7.75< / annotation>< / semantics> (d, <semantics>J=8.2 Hz<annotation encoding="application / x-tex">J = 8.2 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 7.60 (d, <semantics>J=8.2 Hz<annotation encoding="application / x-tex">J = 8.2 \text{ Hz}< / annotation>< / semantics>, 1H), 7.15 (m, 2H), 6.83-6.92 (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>6.73−6.76<annotation encoding="application / x-tex">6.73-6.76< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass (FAB) m / z <semantics>416<annotation encoding="application / x-tex">416< / annotation>< / semantics> [M+H] + <semantics>⟨Example38⟩(E)−3−(2−(oxazol−5−y1)−6−y1)<annotation encoding="application / x-tex">\langle Example \qquad 38 \rangle \qquad (E) -3 - (2 - (oxazol - 5 - y1) - 6 - y1)< / annotation>< / semantics> 5 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 51%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.12 (s, 1H), 9.97 (s, 1H), 10 8.29 (s, 1H), <semantics>7.75<annotation encoding="application / x-tex">7.75< / annotation>< / semantics> (d, <semantics>J=8.2<annotation encoding="application / x-tex">J = 8.2< / annotation>< / semantics> Hz, 1H), <semantics>7.60<annotation encoding="application / x-tex">7.60< / annotation>< / semantics> (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 8.2 Hz, 1H), 7.09 (m, 2H), 6.83-6.92 (m, 2H), 6.73- 6.76 (m, 2H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 416 [M+H]+ <semantics>⟨Example39⟩<annotation encoding="application / x-tex">\langle Example 39 \rangle< / annotation>< / semantics> (E) -3-(2-(3,3-dimethyl-1-butyn-1- 15 yl)-6-(trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 67%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.16 (s, 1H), 9.99 (s, 1H), 8.35 (d, J <semantics>=8.0 Hz,1H),7.95 (d, J=16.0 Hz,1H),7.16 (d, J=16.0 Hz,1H)<annotation encoding="application / x-tex">= 8.0 \text{ Hz}, 1\text{H}), 7.95 \text{ (d, J} = 16.0 \text{ Hz}, 1\text{H}), 7.16 \text{ (d, J} = 16.0 \text{ Hz}, 1\text{H})< / annotation>< / semantics> 8.0 Hz, 1H), 7.02 (d, <semantics>J=16.0<annotation encoding="application / x-tex">J = 16.0< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=16.0<annotation encoding="application / x-tex">J = 16.0< / annotation>< / semantics> 5 8.0 Hz, 1H), 6.75 (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 1.35 (s, 9H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 429 [M+H] + <Example <semantics>40><annotation encoding="application / x-tex">40>< / annotation>< / semantics> (E) -3-(2-(3,3-dimethylbutyl) -6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 10 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 82%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.14 (s, 1H), 9.97 (s, 1H), 8.20 (d, J <semantics>=8.0 Hz,1H),7.80 (m, 2H),7.19 (d, J=8.0 Hz,1H),<annotation encoding="application / x-tex">= 8.0 \text{ Hz}, 1\text{H}), 7.80 \text{ (m, 2H)}, 7.19 \text{ (d, J} = 8.0 \text{ Hz}, 1\text{H)},< / annotation>< / semantics> 15 6.87-6.91 (m, 2H), 6.72 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, 1H), 2.88 (m, 2H), 1.47 (m, 2H); Mass (FAB) m / z 433 [M+H]+ <Example 41> <semantics>(E)−3−(2−cyclopentyl−6−<annotation encoding="application / x-tex">(E) - 3 - (2 - cyclopentyl - 6 -< / annotation>< / semantics> (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 82%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.13 (s, 1H), 9.95 (s, 1H), 8.14 (d, J <semantics>=8.0 Hz,1H),7.87 (d, J=15.6 Hz,1H),7.76 (d, J=<annotation encoding="application / x-tex">= 8.0 \text{ Hz}, 1\text{H}), 7.87 \text{ (d, J} = 15.6 \text{ Hz}, 1\text{H}), 7.76 \text{ (d, J} =< / annotation>< / semantics> 8.0 Hz, 1H), 7.16 (d, <semantics>J=7.6<annotation encoding="application / x-tex">J = 7.6< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 7.6 Hz, 1H), <semantics>6.80−6.73<annotation encoding="application / x-tex">6.80-6.73< / annotation>< / semantics> (m, 2H), <semantics>3.62−3.54<annotation encoding="application / x-tex">3.62-3.54< / annotation>< / semantics> (m, 1H), <semantics>1.95<annotation encoding="application / x-tex">1.95< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.85−1.76<annotation encoding="application / x-tex">1.85-1.76< / annotation>< / semantics> (m, <semantics>4H<annotation encoding="application / x-tex">4H< / annotation>< / semantics>), <semantics>1.65<annotation encoding="application / x-tex">1.65< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass <semantics>(FAB)m / z417[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 417 [M+H]^+< / annotation>< / semantics> <Example 42> <semantics>(E)−3−(2−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4−isobutoxy−4<annotation encoding="application / x-tex">(E) - 3 - (2 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4 - isobutoxy - 4< / annotation>< / semantics> (trifluoromethyl) phenyl) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 71%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 15 10.69 (s, 1H), 10.10 (s, 1H), 9.85 (s, 1H), 7.89 (d, J <semantics>=15.2 Hz,1H),7.80 (d, J=7.9 Hz,1H),7.36 (m, m)<annotation encoding="application / x-tex">= 15.2 \text{ Hz}, 1 \text{H}), 7.80 \text{ (d, J} = 7.9 \text{ Hz}, 1 \text{H}), 7.36 \text{ (m, m)}< / annotation>< / semantics> 2H), 7.20 (d, <semantics>J=8.2 Hz<annotation encoding="application / x-tex">J = 8.2 \text{ Hz}< / annotation>< / semantics>, 1H), 6.88 - 6.93 (m, 2H), <semantics>6.75<annotation encoding="application / x-tex">6.75< / annotation>< / semantics> (d, <semantics>J=7.7<annotation encoding="application / x-tex">J = 7.7< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>3.95<annotation encoding="application / x-tex">3.95< / annotation>< / semantics> (d, <semantics>J=6.2<annotation encoding="application / x-tex">J = 6.2< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.97−2.12<annotation encoding="application / x-tex">1.97-2.12< / annotation>< / semantics> (m, 1H), <semantics>1.02<annotation encoding="application / x-tex">1.02< / annotation>< / semantics> (d, <semantics>J=6.6<annotation encoding="application / x-tex">J = 6.6< / annotation>< / semantics> Hz, 6H); Mass <semantics>(ESI)m / z420[M+H]+<annotation encoding="application / x-tex">(ESI) m / z 420 [M+H] +< / annotation>< / semantics> <semantics>⟨Example43⟩<annotation encoding="application / x-tex">\langle Example 43 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -4- 5 (trifluoromethy1)pheny1)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] . Yellow solid, yield 65%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.12 (s, 1H), 9.88, (s, 1H), 7.89 (d, <semantics>J=15.8 Hz,1H),7.81(d,J=7.7 Hz,1H),7.34−7.38<annotation encoding="application / x-tex">J = 15.8 \text{ Hz}, 1\text{H}), 7.81 (d, J = 7.7 \text{ Hz}, 1\text{H}), 7.34-7.38< / annotation>< / semantics> <semantics>(m,2H),7.22(d,J=8.8Hz,1H),6.90−6.96(m,2H),<annotation encoding="application / x-tex">(m, 2H), 7.22 (d, J = 8.8 Hz, 1H), 6.90-6.96 (m, 2H),< / annotation>< / semantics> 6.76 (d, <semantics>J=7.7 Hz<annotation encoding="application / x-tex">J = 7.7 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>4.03<annotation encoding="application / x-tex">4.03< / annotation>< / semantics> (d, <semantics>J=7.1 Hz<annotation encoding="application / x-tex">J = 7.1 \text{ Hz}< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2\text{H}< / annotation>< / semantics>), 1.31-1.16 (m, 1H), 0.62 (m, 2H), 0.38 (m, 2H); Mass <semantics>(FAB)m / z418[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 418 [M+H]^{+}< / annotation>< / semantics> <semantics>⟨Example 44⟩<annotation encoding="application / x-tex">\langle \text{Example } 44 \rangle< / annotation>< / semantics> (E) -3-(2-(cyclopropylmethoxy) -4-(2- hydroxypropan-2-yl)phenyl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 60%; <semantics>1H<annotation encoding="application / x-tex">^{1}\text{H}< / annotation>< / semantics> NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.07 (s, 1H), 9.70 (s, 1H), 7.85 (d, J <semantics>=15.6 Hz<annotation encoding="application / x-tex">= 15.6 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1 \text{H}< / annotation>< / semantics>), <semantics>7.50 (d, J=7.8 Hz<annotation encoding="application / x-tex">7.50 \text{ (d, } J = 7.8 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1 \text{H}< / annotation>< / semantics>), <semantics>7.22 (d, J=7.8 Hz<annotation encoding="application / x-tex">7.22 \text{ (d, } J = 7.8 \text{ Hz}< / annotation>< / semantics> 8.2 Hz, 1H), <semantics>6.99−7.01<annotation encoding="application / x-tex">6.99-7.01< / annotation>< / semantics> (m, 2H), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), <semantics>6.70−6.75<annotation encoding="application / x-tex">6.70-6.75< / annotation>< / semantics> (m, 2H), <semantics>3.91<annotation encoding="application / x-tex">3.91< / annotation>< / semantics> (d, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 2H), <semantics>1.24<annotation encoding="application / x-tex">1.24< / annotation>< / semantics> <semantics>(s,6H),0.57(t,J=6.2Hz,2H),0.34(t,J=5.0)<annotation encoding="application / x-tex">(s, 6H), 0.57 (t, J = 6.2 Hz, 2H), 0.34 (t, J = 5.0)< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 408 <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <Example <semantics>45<annotation encoding="application / x-tex">45< / annotation>< / semantics> (E) <semantics>−3−(4−(tert−buty1)−2−<annotation encoding="application / x-tex">-3-(4-(tert-buty1)-2-< / annotation>< / semantics> (cyclopropylmethoxy)phenyl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 70%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.07 (s, 1H), 9.70 (s, 1H), 7.85 (d, J <semantics>=15.6 Hz<annotation encoding="application / x-tex">= 15.6 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.50 (d, J=7.8 Hz<annotation encoding="application / x-tex">7.50 \text{ (d, J} = 7.8 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.22 (d, J=<annotation encoding="application / x-tex">7.22 \text{ (d, J} =< / annotation>< / semantics> 8.2 Hz, 1H), <semantics>6.99−7.01<annotation encoding="application / x-tex">6.99-7.01< / annotation>< / semantics> (m, 2H), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, J = 8.0 Hz, 1H), <semantics>6.70−6.76<annotation encoding="application / x-tex">6.70-6.76< / annotation>< / semantics> (m, 2H), <semantics>3.92<annotation encoding="application / x-tex">3.92< / annotation>< / semantics> (d, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 2H), <semantics>1.25<annotation encoding="application / x-tex">1.25< / annotation>< / semantics> <semantics>(s,10H),0.57(t,J=6.2Hz,2H),0.34(t,J=5.0)<annotation encoding="application / x-tex">(s, 10H), 0.57 (t, J = 6.2 Hz, 2H), 0.34 (t, J = 5.0)< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 406 <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> <semantics>⟨Example<annotation encoding="application / x-tex">\langle Example< / annotation>< / semantics> <semantics>⟨E⟩−3−(4−cyclopropyl−2−<annotation encoding="application / x-tex">\langle E \rangle -3 - (4-cyclopropyl-2-< / annotation>< / semantics> 5 (cyclopropylmethoxy)phenyl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; <semantics>1H-NMR<annotation encoding="application / x-tex">^{1}\text{H-NMR}< / annotation>< / semantics> (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.05 (s, 1H), 9.66 (s, 1H), 7.82 (d, J <Formule mathématique disponible dans le document PDF, Math available in the PDF document>10 = 15.6 \text{ Hz}, 1\text{H}), 7.43 (d, J = 7.8 \text{ Hz}, 1\text{H}), 7.21 (d, J = 7.8 \text{ Hz}, 1\text{H}), 7.21 (d, J = 7.8 \text{ Hz}, 1\text{H}), 7.21 (d, J = 7.8 \text{ Hz}, 1\text{H}), 7.21 (d, J = 7.8 \text{ Hz}, 1\text{H}), 7.21 (d, J = 7.8 \text{ Hz}, 1\text{H 7.8 Hz, 1H), 6.87 (t, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.66-6.72 (m, 4H), 3.88 (d, <semantics>J=6.9 Hz<annotation encoding="application / x-tex">J = 6.9 \text{ Hz}< / annotation>< / semantics>, 2H), 1.87-1.95 (m, 1H), 1.25 <semantics>(m,1H),0.95(t,J=6.4Hz,2H),0.71(d,J=4.6)<annotation encoding="application / x-tex">(m, 1H), 0.95 (t, J = 6.4 Hz, 2H), 0.71 (d, J = 4.6)< / annotation>< / semantics> Hz, 2H), 0.57 (d, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, 2H), 0.32 (d, <semantics>J=4.6<annotation encoding="application / x-tex">J = 4.6< / annotation>< / semantics> 15 Hz, 2H); Mass (FAB) m / z 390 [M+H] + <semantics>⟨Example47⟩(E)−3−(1−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)<annotation encoding="application / x-tex">\langle Example 47 \rangle (E) -3 - (1 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl)< / annotation>< / semantics> <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 82%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.73 (s, 1H), 10.14 (s, 1H), 10.02 (s, 1H), 7.78 (m, 1H), 7.67 (m, 2H), 7.60 (m, 1H), 7.50 (s, 1H), 7.26 <semantics>5<annotation encoding="application / x-tex">5< / annotation>< / semantics> (d, <semantics>J=15.54<annotation encoding="application / x-tex">J = 15.54< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.15<annotation encoding="application / x-tex">7.15< / annotation>< / semantics> (d, <semantics>J=7.86<annotation encoding="application / x-tex">J = 7.86< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.91<annotation encoding="application / x-tex">6.91< / annotation>< / semantics> <semantics>(t,J=8.04Hz,1H),6.88(d,J=15.6Hz,1H),6.76<annotation encoding="application / x-tex">(t, J = 8.04 Hz, 1H), 6.88 (d, J = 15.6 Hz, 1H), 6.76< / annotation>< / semantics> <semantics>(d,J=7.68Hz,1H);Mass(FAB)m / z448[M+H]<annotation encoding="application / x-tex">(d, J = 7.68 Hz, 1H); Mass (FAB) m / z 448 [M+H]< / annotation>< / semantics> <semantics>⟨Example48⟩(E)−N−(2−0×0−2,3−dihydro-1H−1)<annotation encoding="application / x-tex">\langle \text{Example} \qquad 48 \rangle \qquad (E) -N - (2 - 0 \times 0 - 2, 3 - \text{dihydro-} 1H - 1)< / annotation>< / semantics> 10 benzo[d]imidazol-4-yl)-3-(1-(m-tolyl)-3- (trifluoromethyl) -1H-pyrazol-5-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 60%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> <semantics>10.69<annotation encoding="application / x-tex">10.69< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>10.11<annotation encoding="application / x-tex">10.11< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>9.99<annotation encoding="application / x-tex">9.99< / annotation>< / semantics>, (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.42−7.55<annotation encoding="application / x-tex">7.42-7.55< / annotation>< / semantics> 15 (m, 4H), 7.35 (d, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H), 7.26 (d, <semantics>J=15.7<annotation encoding="application / x-tex">J = 15.7< / annotation>< / semantics> Hz, 1H), 7.15 (d, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H), 6.86-6.93 (m, 2H), 6.76 (d, <semantics>J=7.7Hz<annotation encoding="application / x-tex">J = 7.7 Hz< / annotation>< / semantics>, 1H), 2.42 (s, 3H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> <semantics>428[M+H]+<annotation encoding="application / x-tex">428 [M+H]^{+}< / annotation>< / semantics> <semantics>⟨Example 49⟩<annotation encoding="application / x-tex">\langle \text{Example } 49 \rangle< / annotation>< / semantics> (E) -3-(1-(3-chloro-4-fluorophenyl) - <semantics>3−(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] 5 Light yellow solid, yield 73%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.10 (s, 1H), 9.99, (s, 1H), 7.99 (dd, <semantics>J=6.78<annotation encoding="application / x-tex">J = 6.78< / annotation>< / semantics>, 2.55 Hz, 1H), 7.69-7.74 (m, 2H), 7.48 (s, 1H), 7.24 (d, <semantics>J=15.8 Hz<annotation encoding="application / x-tex">J = 15.8 \text{ Hz}< / annotation>< / semantics>, 1H), 7.15 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 8.1 Hz, 1H), 6.92 (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.85 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 10 16.3 Hz, 1H), 6.76 (d, <semantics>J=7.9<annotation encoding="application / x-tex">J = 7.9< / annotation>< / semantics> Hz, 1H); Mass (FAB) m / z 466 [M+H]+ <semantics>⟨Example50⟩(E)−3−(1−(3−isopropylphenyl)−3−(1−(3−isopropylphenyl)−3−(1−(3−isopropylphenyl)−3−(1−(3−isopropylphenyl)−3−(1−(3−isopropylphenyl)−3−(1−(3−isopropylphenyl)<annotation encoding="application / x-tex">\langle Example \qquad 50 \rangle \qquad (E) -3 - (1 - (3 - isopropylphenyl) - 3 - (1 - (3 - isopropylphenyl) - 3 - (1 - (3 - isopropylphenyl) - 3 - (1 - (3 - isopropylphenyl) - 3 - (1 - (3 - isopropylphenyl) - 3 - (1 - (3 - isopropylphenyl)< / annotation>< / semantics> <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> 15 dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Light yellow solid, yield 66%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.09 (s, 1H), 9.98 (s, 1H), <semantics>7.58−7.44<annotation encoding="application / x-tex">7.58-7.44< / annotation>< / semantics> (m, 4H), <semantics>7.37<annotation encoding="application / x-tex">7.37< / annotation>< / semantics> (m, 1H), <semantics>7.28<annotation encoding="application / x-tex">7.28< / annotation>< / semantics> (d, J = 15.75 <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.15<annotation encoding="application / x-tex">7.15< / annotation>< / semantics> (d, <semantics>J=8.25<annotation encoding="application / x-tex">J = 8.25< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.93−6.80<annotation encoding="application / x-tex">6.93 - 6.80< / annotation>< / semantics> (m, 5 2H), 6.76 (d, <semantics>J=7.5<annotation encoding="application / x-tex">J = 7.5< / annotation>< / semantics> Hz, 1H), 3.02 (m, 1H), 1.26 (s, <semantics>3H)<annotation encoding="application / x-tex">3H)< / annotation>< / semantics>, 1.24 (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>); Mass (FAB) m / z 456 [M+H]+ <semantics>⟨Example51⟩(E)−3−(1−(3−chlorophenyl)−3−(2−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)−3−(3−chlorophenyl)<annotation encoding="application / x-tex">\langle Example \qquad 51 \rangle \qquad (E) -3 - (1 - (3 - chlorophenyl) -3 - (2 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl) -3 - (3 - chlorophenyl)< / annotation>< / semantics> isopropyl-1H-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- 10 benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 46%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.10 (s, 1H), 9.90 (s, 1H), 7.59 (m, 3H), <semantics>7.46<annotation encoding="application / x-tex">7.46< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.31<annotation encoding="application / x-tex">7.31< / annotation>< / semantics> (d, <semantics>J=15.39<annotation encoding="application / x-tex">J = 15.39< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.19<annotation encoding="application / x-tex">7.19< / annotation>< / semantics> (m, 1H), 6.90 (m, 1H), 6.81 (m, 3H), 3.0 (m, 1H), 1.28 <semantics>(d,J=6.96 Hz,4H); Mass (FAB) m / z 422 [M+H]+<annotation encoding="application / x-tex">(d, J = 6.96 \text{ Hz}, 4\text{H}); \text{ Mass (FAB) m / z } 422 \text{ [M+H]}^+< / annotation>< / semantics> <Example <semantics>52>(E)−3−(1−(3−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlorophenyl)−3−(1−chlo<annotation encoding="application / x-tex">52 > (E) -3 - (1 - (3 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlorophenyl) -3 - (1 - chlo< / annotation>< / semantics> methylcyclopropyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 87%; <semantics>1H<annotation encoding="application / x-tex">^{1}\text{H}< / annotation>< / semantics> NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> <semantics>10.70<annotation encoding="application / x-tex">10.70< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>10.10<annotation encoding="application / x-tex">10.10< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>9.90<annotation encoding="application / x-tex">9.90< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.61−7.58<annotation encoding="application / x-tex">7.61-7.58< / annotation>< / semantics> <semantics>(m,3H),7.44(m,1H),7.28(d,J=15.39Hz,1H),<annotation encoding="application / x-tex">(m, 3H), 7.44 (m, 1H), 7.28 (d, J = 15.39 Hz, 1H),< / annotation>< / semantics> 7.20 (d, <semantics>J=8.25 Hz<annotation encoding="application / x-tex">J = 8.25 \text{ Hz}< / annotation>< / semantics>, 1H), 6.90 (m, 1H), 6.78-6.71 (m, 3H), 1.45 (s, 3H), 1.23 (s, 1H), 0.99 (m, 2H), 0.80 <semantics>(m,2H)<annotation encoding="application / x-tex">(m, 2H)< / annotation>< / semantics>; Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 434 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ <semantics>⟨Example<annotation encoding="application / x-tex">\langle Example< / annotation>< / semantics> 53<semantics>⟩<annotation encoding="application / x-tex">\rangle< / annotation>< / semantics> (E) -3-(3-(tert-butyl) -1-(3- chlorophenyl) -1H-pyrazol-5-yl) -N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 88%; 1H NMR (300 MHz, DMSO- D6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.73 (s, 1H), 10.09 (s, 1H), 9.87, (s, 1H), <semantics>7.57−7.64<annotation encoding="application / x-tex">7.57-7.64< / annotation>< / semantics> (m, 3H), <semantics>7.44−7.47<annotation encoding="application / x-tex">7.44-7.47< / annotation>< / semantics> (m, 1H), <semantics>7.32<annotation encoding="application / x-tex">7.32< / annotation>< / semantics> (d, J = 15.4 Hz, 1H), 7.20 (d, <semantics>J=8.0 Hz<annotation encoding="application / x-tex">J = 8.0 \text{ Hz}< / annotation>< / semantics>, 1H), 6.86-6.93 (m, 2H), <semantics>6.74−6.79<annotation encoding="application / x-tex">6.74-6.79< / annotation>< / semantics> (m, 2H), <semantics>1.33<annotation encoding="application / x-tex">1.33< / annotation>< / semantics> (s, 9H); Mass (FAB) m / z 436 [M+H]+ <Example 54> <semantics>(E)−3−(4−(3−chloropheny1)−2−<annotation encoding="application / x-tex">(E) -3 - (4 - (3 - chloropheny1) -2 -< / annotation>< / semantics> (trifluoromethyl) thiazol-5-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 77%; 1H-NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.70 (s, 1H), 10.08 (s, 1H), 10.02 (s, 1H), 7.66 (d, <semantics>J=10.8 Hz<annotation encoding="application / x-tex">J = 10.8 \text{ Hz}< / annotation>< / semantics>, 1H), 7.59 (m, 4H), 7.12 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 8.0 Hz, 1H), 6.88 (t, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 6.80 (d, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> 15.6 Hz, 1H), 6.74 (d, <semantics>J=8.0Hz<annotation encoding="application / x-tex">J = 8.0 Hz< / annotation>< / semantics>, 1H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 465 [M+H]+ <semantics>⟨Example<annotation encoding="application / x-tex">\langle Example< / annotation>< / semantics> 55> <semantics>(E)−3−(4−(3−chloropheny1)−2−<annotation encoding="application / x-tex">(E) -3 - (4 - (3 - chloropheny1) -2 -< / annotation>< / semantics> isopropylthiazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- 15 benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 78%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.69 (s, 1H), 10.05 (s, 1H), 9.85 (s, 1H), 7.63 (d, <semantics>J=15.2 Hz<annotation encoding="application / x-tex">J = 15.2 \text{ Hz}< / annotation>< / semantics>, 1H), 7.63 (s, 1H), 7.56-7.52 (m, 3H), <semantics>7.17<annotation encoding="application / x-tex">7.17< / annotation>< / semantics> (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=7.6 Hz<annotation encoding="application / x-tex">J = 7.6 \text{ Hz}< / annotation>< / semantics>, 1H), 6.56 (d, <semantics>J=15.6 Hz<annotation encoding="application / x-tex">J = 15.6 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>3.35<annotation encoding="application / x-tex">3.35< / annotation>< / semantics> (m, 1H), <semantics>1.37<annotation encoding="application / x-tex">1.37< / annotation>< / semantics> (d, <semantics>J=6.8<annotation encoding="application / x-tex">J = 6.8< / annotation>< / semantics> Hz, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>); Mass <semantics>5 (FAB) m / z 439 [M+H]+<annotation encoding="application / x-tex">5 \text{ (FAB) } \text{m / z} \text{ 439 } [\text{M+H}]^+< / annotation>< / semantics> <semantics>⟨Example56⟩(E)−3−(4−(3−chlorophenyl)−2−(4−(3−chlorophenyl)−2−(4−(3−chlorophenyl)−2−(4−(3−chlorophenyl)−2−(4−(3−chlorophenyl)−2−(4−(3−chlorophenyl)−2−(4−(3−chloroph<annotation encoding="application / x-tex">\langle Example \qquad 56 \rangle \qquad (E) -3 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chlorophenyl) -2 - (4 - (3 - chloroph< / annotation>< / semantics> cyclopropylthiazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 78%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics>10.69 (s, 1H), 10.05 (s, 1H), 9.84 (s, 1H), 7.61 (s, 1H), 7.60 (d, <semantics>J=15.6 Hz<annotation encoding="application / x-tex">J = 15.6 \text{ Hz}< / annotation>< / semantics>, 1H), 7.56 -7.53 <semantics>(m,3H),7.17(d,J=8.0Hz,1H),6.88(t,J=8.4)<annotation encoding="application / x-tex">(m, 3H), 7.17 (d, J = 8.0 Hz, 1H), 6.88 (t, J = 8.4)< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=7.2<annotation encoding="application / x-tex">J = 7.2< / annotation>< / semantics> Hz, 1H), 6.50 (d, <semantics>J=15.6<annotation encoding="application / x-tex">J = 15.6< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.21<annotation encoding="application / x-tex">1.21< / annotation>< / semantics> (m, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.10<annotation encoding="application / x-tex">1.10< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (<semantics>FAB<annotation encoding="application / x-tex">FAB< / annotation>< / semantics>) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 437 [M+H]+ <Example <semantics>57><annotation encoding="application / x-tex">57>< / annotation>< / semantics> (E) <semantics>−3−(4−(3−chlorophenyl)−2−(1−<annotation encoding="application / x-tex">-3-(4-(3-chlorophenyl)-2-(1-< / annotation>< / semantics> methylcyclopropyl)thiazol-5-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 66%; 1H NMR (400MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.68 (s, 1H), 10.03 (s, 1H), 9.81 (s, 1H), 7.59 (m, 1H), 7.58 (d, <semantics>J=15.2 Hz<annotation encoding="application / x-tex">J = 15.2 \text{ Hz}< / annotation>< / semantics>, 1H), 7.54 -7.49 <semantics>(m,3H),7.15(d,J=8.4Hz,1H),6.86(t,J=8.0)<annotation encoding="application / x-tex">(m, 3H), 7.15 (d, J = 8.4 Hz, 1H), 6.86 (t, J = 8.0)< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.71<annotation encoding="application / x-tex">6.71< / annotation>< / semantics> (<semantics>d<annotation encoding="application / x-tex">d< / annotation>< / semantics>, <semantics>J=7.2<annotation encoding="application / x-tex">J = 7.2< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.51<annotation encoding="application / x-tex">6.51< / annotation>< / semantics> (<semantics>d<annotation encoding="application / x-tex">d< / annotation>< / semantics>, <semantics>J=15.2<annotation encoding="application / x-tex">J = 15.2< / annotation>< / semantics> <semantics>Hz<annotation encoding="application / x-tex">Hz< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.55<annotation encoding="application / x-tex">1.55< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.31<annotation encoding="application / x-tex">1.31< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.08<annotation encoding="application / x-tex">1.08< / annotation>< / semantics> (m, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 451 [M+H] + <Example <semantics>58<annotation encoding="application / x-tex">58< / annotation>< / semantics> (E) -3-(2-(tert-buty1) -4-(3- chlorophenyl) thiazol-5-yl) -N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)acrylamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 66%; 1H NMR (400 MHz, 15 DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.01 (s, 1H), 9.82 (s, 1H), 7.67 (d, <semantics>J=15.2 Hz<annotation encoding="application / x-tex">J = 15.2 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), 7.66 (m, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), 7.58 (m, <semantics>3H<annotation encoding="application / x-tex">3\text{H}< / annotation>< / semantics>), 7.21 (d, <semantics>J=8.12 Hz<annotation encoding="application / x-tex">J = 8.12 \text{ Hz}< / annotation>< / semantics>, <semantics>IH<annotation encoding="application / x-tex">IH< / annotation>< / semantics>), <semantics>6.91<annotation encoding="application / x-tex">6.91< / annotation>< / semantics> (t, <semantics>J=7.96 Hz<annotation encoding="application / x-tex">J = 7.96 \text{ Hz}< / annotation>< / semantics>, <semantics>IH<annotation encoding="application / x-tex">IH< / annotation>< / semantics>), <semantics>6.75<annotation encoding="application / x-tex">6.75< / annotation>< / semantics> (d, <semantics>J=7.72<annotation encoding="application / x-tex">J = 7.72< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.60<annotation encoding="application / x-tex">6.60< / annotation>< / semantics> (d, <semantics>J=15.2<annotation encoding="application / x-tex">J = 15.2< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 1.46 (s, 9H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 453 [M+H]+ <Example 59> 3-(2-isobutoxy-6- 5 (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)propaneamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 86%; 1H NMR (500 MHz, CDC13) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 9.14 (s, 1H), 8.16 (s, 1H), 7.58 (d, J = 7.35) 10 Hz, 1H), 7.27 (s, 1H), 7.16 (d, <semantics>J=7.40<annotation encoding="application / x-tex">J = 7.40< / annotation>< / semantics> Hz, 1H), 6.93 <semantics>(t,J=7.90 Hz,1H),6.81(d,J=7.75 Hz,1H),6.58<annotation encoding="application / x-tex">(t, J = 7.90 \text{ Hz}, 1\text{H}), 6.81 (d, J = 7.75 \text{ Hz}, 1\text{H}), 6.58< / annotation>< / semantics> <semantics>(d,J=8.05Hz,1H),4.16(d,J=6.45Hz,2H),3.05<annotation encoding="application / x-tex">(d, J = 8.05 Hz, 1H), 4.16 (d, J = 6.45 Hz, 2H), 3.05< / annotation>< / semantics> <semantics>(t,J=7.25Hz,2H),2.74(t,J=7.25Hz,2H),2.11<annotation encoding="application / x-tex">(t, J = 7.25 Hz, 2H), 2.74 (t, J = 7.25 Hz, 2H), 2.11< / annotation>< / semantics> <semantics>(p,J=6.70 Hz,1H),1.03(d,J=6.65 Hz,6H); Mass<annotation encoding="application / x-tex">(p, J = 6.70 \text{ Hz}, 1\text{H}), 1.03 (d, J = 6.65 \text{ Hz}, 6\text{H}); \text{ Mass}< / annotation>< / semantics> 15 (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 423 [M+H] + <Example 60> 3-(2-(cyclopropylmethoxy)-6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)propaneimide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 77%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.66 (s, 1H), 10.08 (s, 1H), 9.53 (s, 1H), 7.80 (d, J <semantics>=7.50 Hz<annotation encoding="application / x-tex">= 7.50 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.41 (d, J=6.00 Hz<annotation encoding="application / x-tex">7.41 \text{ (d, J} = 6.00 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.07 (d, J)<annotation encoding="application / x-tex">7.07 \text{ (d, J)}< / annotation>< / semantics> <semantics>=8.25 Hz<annotation encoding="application / x-tex">= 8.25 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.87 (t, J=7.86 Hz<annotation encoding="application / x-tex">6.87 \text{ (t, J} = 7.86 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.72 (d, J)<annotation encoding="application / x-tex">6.72 \text{ (d, J)}< / annotation>< / semantics> <semantics>=7.86 Hz,1H),4.20 (d, J=6.96 Hz,2H),2.96 (t, J)<annotation encoding="application / x-tex">= 7.86 \text{ Hz}, 1\text{H}), 4.20 \text{ (d, J} = 6.96 \text{ Hz}, 2\text{H}), 2.96 \text{ (t, J)}< / annotation>< / semantics> <semantics>=7.14 Hz.2H)<annotation encoding="application / x-tex">= 7.14 \text{ Hz.} 2H)< / annotation>< / semantics>, <semantics>2.70 (t, J=7.50 Hz, 2H)<annotation encoding="application / x-tex">2.70 \text{ (t, } J = 7.50 \text{ Hz, } 2H)< / annotation>< / semantics>, <semantics>1.28 (m, <annotation encoding="application / x-tex">1.28 \text{ (m, }< / annotation>< / semantics> 1H), <semantics>0.55<annotation encoding="application / x-tex">0.55< / annotation>< / semantics> (q, <semantics>J=5.70<annotation encoding="application / x-tex">J = 5.70< / annotation>< / semantics> Hz, 2H), <semantics>0.40<annotation encoding="application / x-tex">0.40< / annotation>< / semantics> (q, <semantics>J=5.70<annotation encoding="application / x-tex">J = 5.70< / annotation>< / semantics> Hz, 2H); Mass (FAB) m / z 421 [M+H] + <Example 61> 2-(2-isobutoxy-6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)cyclopropan-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Pale yellow solid, yield 72%; 1H NMR (500 MHz, <semantics>CDCl3<annotation encoding="application / x-tex">CDCl_3< / annotation>< / semantics>) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 9.14 (s, 1H), 8.16 (s, 1H), 7.58 (d, <semantics>J=7.35<annotation encoding="application / x-tex">J = 7.35< / annotation>< / semantics> Hz, 1H), 7.27 (s, 1H), 7.16 (d, <semantics>J=7.40<annotation encoding="application / x-tex">J = 7.40< / annotation>< / semantics> Hz, 1H), 6.93 <semantics>(t,J=7.90 Hz,1H),6.81(d,J=7.75 Hz,1H),6.58<annotation encoding="application / x-tex">(t, J = 7.90 \text{ Hz}, 1\text{H}), 6.81 (d, J = 7.75 \text{ Hz}, 1\text{H}), 6.58< / annotation>< / semantics> <semantics>(d,J=8.05 Hz,1H),4.16(d,J=6.45 Hz,2H),3.11<annotation encoding="application / x-tex">(d, J = 8.05 \text{ Hz}, 1\text{H}), 4.16 (d, J = 6.45 \text{ Hz}, 2\text{H}), 3.11< / annotation>< / semantics> <semantics>(s,1H),2.89(s,1H),2.11(p,J=6.70Hz,1H),1.23<annotation encoding="application / x-tex">(s, 1H), 2.89 (s, 1H), 2.11 (p, J = 6.70 Hz, 1H), 1.23< / annotation>< / semantics> <semantics>(m,2H),1.03(d,J=6.65Hz,6H),0.89(m,1H);Mass<annotation encoding="application / x-tex">(m, 2H), 1.03 (d, J = 6.65 Hz, 6H), 0.89 (m, 1H); Mass< / annotation>< / semantics> <semantics>(FAB)m / z435[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 435 [M+H]^+< / annotation>< / semantics> 5 <Example 62> 2-(2-(cyclopropylmethoxy)-6- (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 65%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10 10.66 (s, 1H), 10.08 (s, 1H), 9.53 (s, 1H), 7.80 (d, J <semantics>=7.50 Hz,1H,7.41 (d, J=6.00 Hz,1H),7.07 (d, J)<annotation encoding="application / x-tex">= 7.50 \text{ Hz}, 1\text{H}, 7.41 \text{ (d, J} = 6.00 \text{ Hz}, 1\text{H}), 7.07 \text{ (d, J)}< / annotation>< / semantics> <semantics>=8.25 Hz,1H),6.87 (t, J=7.86 Hz,1H),6.72 (d, J<annotation encoding="application / x-tex">= 8.25 \text{ Hz}, 1\text{H}), 6.87 \text{ (t, } J = 7.86 \text{ Hz}, 1\text{H}), 6.72 \text{ (d, } J< / annotation>< / semantics> <semantics>=7.86 Hz,1H,4.20 (d, J=6.96 Hz,2H),2.96 (t, J)<annotation encoding="application / x-tex">= 7.86 \text{ Hz}, 1\text{H}, 4.20 \text{ (d, J} = 6.96 \text{ Hz}, 2\text{H}), 2.96 \text{ (t, J)}< / annotation>< / semantics> <semantics>=7.14 Hz.2H)<annotation encoding="application / x-tex">= 7.14 \text{ Hz}. 2H)< / annotation>< / semantics>, <semantics>2.70 (t, J=7.50 Hz,2H)<annotation encoding="application / x-tex">2.70 \text{ (t, } J = 7.50 \text{ Hz}, 2H)< / annotation>< / semantics>, <semantics>1.28 (m, <annotation encoding="application / x-tex">1.28 \text{ (m, }< / annotation>< / semantics> 15 3H), 0.80 (m, 1H), 0.55 (q, <semantics>J=5.70 Hz<annotation encoding="application / x-tex">J = 5.70 \text{ Hz}< / annotation>< / semantics>, 2H), 0.40 (q, <semantics>J=5.70 Hz,2H<annotation encoding="application / x-tex">J = 5.70 \text{ Hz}, 2H< / annotation>< / semantics>; Mass (FAB) m / z 433 [M+H]+ <Example 63> <semantics>2−(1−(3−chlorophenyl)−3−<annotation encoding="application / x-tex">2-(1-(3-chlorophenyl)-3-< / annotation>< / semantics> <semantics>(trifluoromethyl)−1H−pyrazol−5−yl)−N−(2−oxo−2,3−<annotation encoding="application / x-tex">(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)cyclopropane-1- carboxamide [Image disponible dans le document PDF, Image available in the PDF document] White solid, yield 78%; 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 9.95 (s, 1H), 9.85 (s, 1H), 7.75 (s, 1H), <semantics>7.66−7.64<annotation encoding="application / x-tex">7.66-7.64< / annotation>< / semantics> (t, <semantics>J=5.88<annotation encoding="application / x-tex">J = 5.88< / annotation>< / semantics> Hz, 1H), <semantics>7.57<annotation encoding="application / x-tex">7.57< / annotation>< / semantics> (s, 2H), <semantics>5<annotation encoding="application / x-tex">5< / annotation>< / semantics> 7.07 (d, <semantics>J=6.52 Hz<annotation encoding="application / x-tex">J = 6.52 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.90<annotation encoding="application / x-tex">6.90< / annotation>< / semantics> (d, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.87<annotation encoding="application / x-tex">6.87< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.74<annotation encoding="application / x-tex">6.74< / annotation>< / semantics> (d, <semantics>J=6.16<annotation encoding="application / x-tex">J = 6.16< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.35<annotation encoding="application / x-tex">2.35< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.18<annotation encoding="application / x-tex">2.18< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), 1.53 (t, <semantics>J=5.92 Hz<annotation encoding="application / x-tex">J = 5.92 \text{ Hz}< / annotation>< / semantics>, 2H), 1.23 (s, 2H), 0.80 (m, 1H); Mass (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> 462 <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics>+ 10 <semantics>⟨Example64⟩2−(1−(3−chlorophenyl)−3−(1,1−12)<annotation encoding="application / x-tex">\langle \text{Example} \qquad 64 \rangle \qquad 2 - (1 - (3 - \text{chlorophenyl}) - 3 - (1, 1 - \frac{1}{2})< / annotation>< / semantics> difluoroethyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 65%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 15 10.67 (s, 1H), 9.95 (s, 1H), 9.87 (s, 1H), 7.63 (s, 1H), <semantics>7.56<annotation encoding="application / x-tex">7.56< / annotation>< / semantics> (m, 1H), <semantics>7.46<annotation encoding="application / x-tex">7.46< / annotation>< / semantics> (t, <semantics>J=8.22<annotation encoding="application / x-tex">J = 8.22< / annotation>< / semantics> Hz, 1H), <semantics>7.41<annotation encoding="application / x-tex">7.41< / annotation>< / semantics> (s, 1H), <semantics>7.10<annotation encoding="application / x-tex">7.10< / annotation>< / semantics> (d, <semantics>J=7.89<annotation encoding="application / x-tex">J = 7.89< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, <semantics>J=7.68<annotation encoding="application / x-tex">J = 7.68< / annotation>< / semantics> Hz, 1H), <semantics>6.73<annotation encoding="application / x-tex">6.73< / annotation>< / semantics> (d, <semantics>J=8.07<annotation encoding="application / x-tex">J = 8.07< / annotation>< / semantics> Hz, 1H), <semantics>6.05<annotation encoding="application / x-tex">6.05< / annotation>< / semantics> (s, 1H), <semantics>1.23<annotation encoding="application / x-tex">1.23< / annotation>< / semantics> (m, [Image disponible dans le document PDF, Image available in the PDF document] <Example 65> 2-(1-(3-chlorophenyl)-3-isopropyl- 5 <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro-1H- benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Pale brown solid, yield 60%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 9.98 (s, 1H), 9.89 (s, 1H), 7.64 (s, 1H), 7.59 (d, <semantics>J=7.68 Hz<annotation encoding="application / x-tex">J = 7.68 \text{ Hz}< / annotation>< / semantics>, 1H), 7.48 (t, <semantics>J=<annotation encoding="application / x-tex">J =< / annotation>< / semantics> <semantics>8.25 Hz<annotation encoding="application / x-tex">8.25 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.42 (m, 1H)<annotation encoding="application / x-tex">7.42 \text{ (m, } 1\text{H)}< / annotation>< / semantics>, <semantics>7.16 (d, J=8.04 Hz<annotation encoding="application / x-tex">7.16 \text{ (d, } J = 8.04 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), 6.88 (t, <semantics>J=7.53 Hz<annotation encoding="application / x-tex">J = 7.53 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.72<annotation encoding="application / x-tex">6.72< / annotation>< / semantics> (d, <semantics>J=7.62 Hz<annotation encoding="application / x-tex">J = 7.62 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.21<annotation encoding="application / x-tex">6.21< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.30<annotation encoding="application / x-tex">2.30< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.19<annotation encoding="application / x-tex">2.19< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.74<annotation encoding="application / x-tex">1.74< / annotation>< / semantics> (s, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>1.51<annotation encoding="application / x-tex">1.51< / annotation>< / semantics> (m, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>1.23<annotation encoding="application / x-tex">1.23< / annotation>< / semantics> (d, <semantics>J=6.78<annotation encoding="application / x-tex">J = 6.78< / annotation>< / semantics> Hz, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>); Mass 15 <semantics>(FAB)m / z436[M+H]+<annotation encoding="application / x-tex">(FAB) m / z 436 [M+H]^{+}< / annotation>< / semantics> <Example 66> 2-(1-(3-chlorophenyl)-3-cyclopropyl- <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>-pyrazol-5-yl) <semantics>−N<annotation encoding="application / x-tex">-N< / annotation>< / semantics>-(2-oxo-2, 3-dihydro-1H- benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 82%; <semantics>1H<annotation encoding="application / x-tex">^{1}\text{H}< / annotation>< / semantics> NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 9.98 (s, 1H), 9.89 (s, 1H), 7.64 (s, 1H), <semantics>7.57<annotation encoding="application / x-tex">7.57< / annotation>< / semantics> (m, 2H), <semantics>7.49<annotation encoding="application / x-tex">7.49< / annotation>< / semantics> (t, <semantics>J=8.25<annotation encoding="application / x-tex">J = 8.25< / annotation>< / semantics> Hz, 2H), <semantics>7.42<annotation encoding="application / x-tex">7.42< / annotation>< / semantics> (m, 2H), <semantics>7.10<annotation encoding="application / x-tex">7.10< / annotation>< / semantics> (d, <semantics>J=7.86<annotation encoding="application / x-tex">J = 7.86< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, <semantics>J=7.68<annotation encoding="application / x-tex">J = 7.68< / annotation>< / semantics> Hz, 1H), 6.73 (d, <semantics>J=7.68 Hz<annotation encoding="application / x-tex">J = 7.68 \text{ Hz}< / annotation>< / semantics>, 1H), 6.05 (s, 1H), 2.32 (m, 1H), 2.08 (m, 1H), 1.95 (m, 2H), 1.51 (m, 1H), 0.89 <semantics>(m,2H),0.67(m,2H);Mass(FAB)m / z434[M+H]<annotation encoding="application / x-tex">(m, 2H), 0.67 (m, 2H); Mass (FAB) m / z 434 [M+H]< / annotation>< / semantics> <Example <semantics>67><annotation encoding="application / x-tex">67>< / annotation>< / semantics> 2-<semantics>(1−(3−chlorophenyl)−3−(1−<annotation encoding="application / x-tex">(1-(3-chlorophenyl)-3-(1-< / annotation>< / semantics> methylcyclopropyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3- dihydro-1H-benzo[d]imidazol-4-yl)cyclopropane-1- carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 73%; 1H NMR (300 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.68 (s, 1H), 9.96 (s, 1H), 9.87 (s, 1H), 7.64 (s, 1H), <semantics>7.57<annotation encoding="application / x-tex">7.57< / annotation>< / semantics> (m, 1H), <semantics>7.49<annotation encoding="application / x-tex">7.49< / annotation>< / semantics> (t, <semantics>J=8.25<annotation encoding="application / x-tex">J = 8.25< / annotation>< / semantics> Hz, 1H), <semantics>7.42<annotation encoding="application / x-tex">7.42< / annotation>< / semantics> (m, 1H), <semantics>7.10<annotation encoding="application / x-tex">7.10< / annotation>< / semantics> (d, <semantics>J=7.86<annotation encoding="application / x-tex">J = 7.86< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (t, <semantics>J=7.68<annotation encoding="application / x-tex">J = 7.68< / annotation>< / semantics> Hz, 1H), <semantics>6.73<annotation encoding="application / x-tex">6.73< / annotation>< / semantics> (d, <semantics>J=7.68<annotation encoding="application / x-tex">J = 7.68< / annotation>< / semantics> Hz, 1H), <semantics>6.12<annotation encoding="application / x-tex">6.12< / annotation>< / semantics> (s, 1H), <semantics>1.40<annotation encoding="application / x-tex">1.40< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>0.91<annotation encoding="application / x-tex">0.91< / annotation>< / semantics> (s, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>0.74<annotation encoding="application / x-tex">0.74< / annotation>< / semantics> (s, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>); <semantics>Mass<annotation encoding="application / x-tex">Mass< / annotation>< / semantics> (FAB) <semantics>m / z<annotation encoding="application / x-tex">m / z< / annotation>< / semantics> <semantics>448<annotation encoding="application / x-tex">448< / annotation>< / semantics> <semantics>[M+H]<annotation encoding="application / x-tex">[M+H]< / annotation>< / semantics> <Example 68> <semantics>2−(3−(tert−buty1)−1−(3−<annotation encoding="application / x-tex">2-(3-(tert-buty1)-1-(3-< / annotation>< / semantics> chlorophenyl)-1H-pyrazol-5-yl)-N-(2-oxo-2,3-dihydro- 1H-benzo[d]imidazol-4-yl)cyclopropane-1-carboxamide [Image disponible dans le document PDF, Image available in the PDF document] Yellow solid, yield 82%; <semantics>1<annotation encoding="application / x-tex">^{1}< / annotation>< / semantics>H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 10.67 (s, 1H), 9.93 (s, 1H), 9.85 (s, 1H), 7.64 (s, 1H), 7.60 (d, <semantics>J=6.92 Hz<annotation encoding="application / x-tex">J = 6.92 \text{ Hz}< / annotation>< / semantics>, 1H), 7.51 (t, <semantics>J=8.00 Hz<annotation encoding="application / x-tex">J = 8.00 \text{ Hz}< / annotation>< / semantics>, 1H), <semantics>7.44<annotation encoding="application / x-tex">7.44< / annotation>< / semantics> (d, <semantics>J=6.92<annotation encoding="application / x-tex">J = 6.92< / annotation>< / semantics> Hz, 1H), <semantics>7.11<annotation encoding="application / x-tex">7.11< / annotation>< / semantics> (d, <semantics>J=8.08<annotation encoding="application / x-tex">J = 8.08< / annotation>< / semantics> Hz, 1H), 6.89 (t, <semantics>J=7.96 Hz<annotation encoding="application / x-tex">J = 7.96 \text{ Hz}< / annotation>< / semantics>, 1H), 6.74 (d, <semantics>J=7.76 Hz<annotation encoding="application / x-tex">J = 7.76 \text{ Hz}< / annotation>< / semantics>, 1H), 6.22 (s, 1H), 2.32 (m, 1H), 2.13 (m, 1H), 1.53 <semantics>(m,1H),1.42(m,1H),1.27(s,9H);Mass(FAB)m / z<annotation encoding="application / x-tex">(m, 1H), 1.42 (m, 1H), 1.27 (s, 9H); Mass (FAB) m / z< / annotation>< / semantics> 450 [M+H]+ The chemical formulas of the compounds prepared in Examples 1-68 are summarized and shown in Table 1 below. [Table 1] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <Comparative Example 1> Preparation of 1-(2-oxo- 1,3-dihydrobenzimidazol-4-yl)-3-[[2-pyrrolidin-1-yl-6- (trifluoromethyl) -3-pyridyl]methyl]urea [Image disponible dans le document PDF, Image available in the PDF document] The compound of Example 39 disclosed in Korean Patent Publication No. 10-2013-0065634 (WO 2011 / 120604 A1) was prepared as the compound of Comparative Example 1. <Comparative Example 2> Preparation of 1-[[2- isopropoxy-6-(trifluoromethy1)-3-pyridy1]methy1]-3-(2- oxo-1,3-dihydrobenzimidazol-4-yl)urea [Image disponible dans le document PDF, Image available in the PDF document] The compound of Example 68 disclosed in Korean Patent Publication No. 10-2013-0065634 (WO 2011 / 120604 A1) was prepared as the compound of Comparative Example 2. <Comparative Example 3> Preparation of 1-(2-oxo- <semantics>1,3−dihydrobenzimidazol−4−yl)−3−[[2−(1−piperidyl)−6−<annotation encoding="application / x-tex">1,3-dihydrobenzimidazol-4-yl)-3-[[2-(1-piperidyl)-6-< / annotation>< / semantics> (trifluoromethyl) -3-pyridyl]methyl]urea [Image disponible dans le document PDF, Image available in the PDF document] The compound of Example 71 disclosed in Korean Patent Publication No. 10-2013-0065634 (WO 2011 / 120604 A1) was prepared as the compound of Comparative Example 3. <Experimental Example 1> Evaluation of antagonism against TRPV1 (transient receptor potential vanilloid- 1) receptor activators (in vitro) As emphasized above, it has been reported that the side effect of increasing body temperature of the first-generation TRPV1 antagonists developed to date is due to antagonism to all TRPV1 receptor activators (capsaicin, heat, pH, NADA). In particular, it has been reported that blocking 100% of pH among the TRPV1 receptor activators caused excessive increase of body temperature, and blocking 20% or less caused proton activation at a high concentration to cause excessive decrease of body temperature. That is, in the development of TRPV1 antagonists, while blocking TRPV1 activation caused by capsaicin and heat, but inducing an appropriate inhibition of about 20% to 80% of pH, it may lead to the effect of not only alleviating pain but also reducing side effects such as abnormal body temperature. Hereinafter, it was evaluated whether the example compounds provided in one aspect of the present invention could block TRPV1 activation caused by capsaicin, but induce an appropriate inhibition of about 20% to 80% of pH, thereby alleviating pain as well as reducing side effects such as abnormal body temperature. Antagonism to capsaicin and pH, the hTRPV1 receptor activators, was searched, and the target was set as <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> (CAP) < 15 nM (efficacy) and 80% inhibition for pH=6 (non-hyperthermia). This is because the <semantics>IC50<annotation encoding="application / x-tex">IC_{50}< / annotation>< / semantics> (CAP) of Mavatrep, a control clinical drug, was investigated as 13.8 nM in our own experiment, and when pH antagonism was less than 80% inhibition, it was considered non-hyperthermia. Ca2+ influx assay PrecisionTM http: / / example.com / html / precisionTM http: / / example.com / html / precisionTM http: / / example.com / html / precisionTM http: / / example.com / html / precisionTM http: / / example.com / html / precisionTM http: / / example.com / html / precis (CYL3063) were purchased from Millipore and used as cells for human TRPV1 (hTRPV1) antagonist assay. DME / F-12 (HyClone) (10% FBS, 1% NEAA, 1% Penicillin streptomycin) was used as a medium, and Fluo4-NW (Molecular Probes, F-36206) was used as an ELISA kit. After culturing the above cells under the conditions of <semantics>37∘<annotation encoding="application / x-tex">37^{\circ}< / annotation>< / semantics>C and <semantics>5%<annotation encoding="application / x-tex">5\%< / annotation>< / semantics> CO2, the cells were inoculated in a 96- well plate at the density of <semantics>5x104<annotation encoding="application / x-tex">5x10^4< / annotation>< / semantics> cells / well, followed by culture for 16 hours. Then, the medium was removed and 100 uL of a staining solution was put into each well, followed by culture for 30 minutes under the conditions of <semantics>37∘C<annotation encoding="application / x-tex">37^{\circ}C< / annotation>< / semantics> and <semantics>5%<annotation encoding="application / x-tex">5\%< / annotation>< / semantics> <semantics>CO2<annotation encoding="application / x-tex">CO_2< / annotation>< / semantics>. Thereafter, the cells were acclimatized to room temperature for 15 minutes, and the test substances (example compounds and comparative example compounds of the present invention) were added to each well, followed by culture at room temperature for 15 minutes. After diluting capsaicin (Sigma, M2028) to a concentration of 10 nM, it was put into each well of the plate and fluorescence was measured (ex485 / em535). In the above experiment, the efficacy of the drug was evaluated using BCTC as a representative TRPV1 antagonist. Evaluation of human pH inhibitory activity PrecisionTM httpv1-Hek recombinant cells (CYL3063) were purchased from Millipore and used. After culturing the above cells under the conditions of 37°C and 5% CO2, the cells were inoculated in a 96- well plate at the density of <semantics>5×104<annotation encoding="application / x-tex">5 \times 10^4< / annotation>< / semantics> cells / well, followed by culture for 16 hours. Then, the medium was removed and 100 uL of a staining solution was put into each well, followed by culture for 30 minutes under the conditions of 37°C and 5% CO2. After 30 minutes, all of the existing staining solution was removed and replaced with 100 uL of HBSS. Thereafter, the cells were acclimatized to room temperature for 15 minutes, and the test substances (example compounds and comparative example compounds of the present invention) were added to each well, followed by culture at room temperature for 15 minutes. Then, the final pH was adjusted to 6.0 using MES, and fluorescence was measured (ex485 / em535). In the pH assay, the efficacy of the drug was evaluated using BCTC as a TRPV1 antagonist. The in vitro test results of <Experimental Example 1> were combined with the in vivo test results of <Experimental Example 2>, which are shown in Table 2 below. <Experimental Example 2> Evaluation of bioavailability (BA) Potency, ADME, and toxicity properties are important for new drug candidates, and as pharmacokinetic properties, they should have a blood concentration profile above a certain level, and based on this, it is very important to check whether the PK- PD correlation is good. Using the PK parameters of new drug candidates obtained from experimental animals such as rats or mice, blood concentration and drug efficacy can be predicted in humans through allometric scaling or PK-PD prediction. For this purpose, it is important to measure Cl and Vss, which determine the dose and administration interval, and to obtain PK parameters such as Cmax, <semantics>t1 / 2<annotation encoding="application / x-tex">t_{1 / 2}< / annotation>< / semantics> and AUCall during oral administration. In addition, basic information related to metabolic enzymes, transporters, and tissue distribution of candidate substances can be obtained, and inappropriate physical properties can be estimated. The information obtained through such an analysis can provide important decision criteria for deriving an optimal candidate, as well as help in the molecular design and development of more efficient drugs. Test method SD rats (Coatec, Hana Trading Co., Ltd., 7-8 weeks old, male, <semantics>n=4<annotation encoding="application / x-tex">n = 4< / annotation>< / semantics>, <semantics>250−300<annotation encoding="application / x-tex">250-300< / annotation>< / semantics> g) were used for the experiment. The rats were bred in a small animal breeding room (experimental animal center) set at a temperature of <semantics>22±2∘C<annotation encoding="application / x-tex">22\pm2^{\circ}C< / annotation>< / semantics>, a relative humidity of <semantics>50±5%<annotation encoding="application / x-tex">50\pm5\%< / annotation>< / semantics>, an illumination time of 12 hours <semantics>(08:00∼20:00)<annotation encoding="application / x-tex">(08:00 \sim 20:00)< / annotation>< / semantics>, and an illumination intensity of 150 to 300 lux. Feed was fed freely during the entire test period, and RO water was provided freely. Before oral administration of the test substances (example compounds and comparative example compounds of the present invention), the rats were fasted for 16 hours. The dosage of the example compounds and comparative example compounds of the present invention was 5 mg / kg when administered intravenously and 10 mg / kg when administered orally. For intravenous administration, a clear solution in which 10% DMSO, 10% Cremophor EL, and 80% PEG400 were dissolved was administered. For oral administration, a solution or suspension in which 10% DMSO and 10% Cremophor EL were dissolved in 80% DDW was administered. After the intravenous or oral administration, blood was collected at 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours and 8 hours, and the concentrations of the test substances (example compounds and comparative example compounds of the present invention) in plasma were measured by After adding 80 µl of acetonitrile (including internal standard) to 20 µl of plasma, centrifugation was performed for 5 minutes at 15,000 rpm at 4°C with 25 vortexing. The supernatant obtained after the centrifugation was analyzed by LC-MS / MS. For HPLC, Nexera XR system (Shimadzu, Japan) was used, and for mass spectrometer, TSQ vantage triple quadruple (Thermo, USA) was used. 5 (ii) HPLC Condition [Image disponible dans le document PDF, Image available in the PDF document] . . ② Mass spectrometry Condition [Image disponible dans le document PDF, Image available in the PDF document] The PK parameters were calculated with a non- compartmental analysis model using Phoenix WinNonlin 10 6.4 version (Pharsight, USA) program. AUC (area under the plasma concentration-time curve) up to 8 hours was calculated from the measured plasma concentration by the trapezoidal rule, and the oral absorption rate (F%) was calculated from the ratio to the AUC when the same dose was administered intravenously. AUC was calculated using the linear trapezoidal rule in the rising plasma-level phase and the logarithmic trapezoidal rule in the declining phase. The results are shown in Table 2 below. [Table 2] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <semantics>*NT=NotTested<annotation encoding="application / x-tex">*NT = Not Tested< / annotation>< / semantics> As shown in Table 2, the example compounds provided in one aspect of the present invention block the TRPV1 activation caused by capsaicin, but induce an appropriate inhibition of about 20% to 80% of pH, thereby the compounds have effects of alleviating pain and reducing side effects such as abnormal body temperature. In addition, it was confirmed that the compounds of the present invention have a high PK value, so that the example compounds are easily absorbed into the body, and thus, thermoneutrality is also maintained. On the other hand, the compounds of Comparative Examples 1 to 3 block the TRPV1 activation caused by capsaicin, but inhibit pH less than or more than necessary, that is, out of the appropriate range of 20% to 80%. In addition, it was confirmed that the compounds of Comparative Examples have a low PK value, and thus, the compounds are not easily absorbed into the body, so that there is a problem in that they are difficult to use as an actual analgesic. <Manufacturing Example 1> Preparation of powders Derivative represented by formula 1 2 g Lactose 1 g Powders were prepared by mixing all the above components, which were filled in airtight packs. <Manufacturing Example 2> preparation of tablets 15 Derivative represented by formula 1 100 mg Corn starch 100 mg Lactose 100 mg Magnesium stearate 2 mg Tablets were prepared by mixing all the above 20 components by the conventional method for preparing tablets. <Manufacturing Example 3> Preparation of capsules Derivative represented by formula 1 <semantics>100 mg<annotation encoding="application / x-tex">100 \text{ mg}< / annotation>< / semantics> Corn starch 100 mg Lactose 100 mg Magnesium stearate 2 mg Capsules were prepared by mixing all the above components, which were filled in gelatin capsules according to the conventional method for preparing capsules. <Manufacturing Example 4> Preparation of injectable solutions Derivative represented by formula 1 100 mg Mannitol 180 mg <semantics>Na2HPO4⋅2H2O<annotation encoding="application / x-tex">Na_2HPO_4 \cdot 2H_2O< / annotation>< / semantics> 26 mg Distilled water <semantics>2974<annotation encoding="application / x-tex">2974< / annotation>< / semantics> mg Injectable solutions were prepared by containing 15 all the above components in the amounts indicated according to the conventional method for preparing injectable solutions. <Manufacturing Example 5> Preparation of health 20 functional foods Derivative represented by formula 1 500 ng Vitamin complex proper amount Vitamin A acetate 70 mg Vitamin E 1.0 mg Vitamin 0.13 mg Vitamin B2 <semantics>0.15 mg<annotation encoding="application / x-tex">0.15 \text{ mg}< / annotation>< / semantics> Vitamin B6 0.5 mg Vitamin B12 0.2 mg Vitamin C 10 mg 5 Biotin 10 mg Nicotinamide 1.7 mg Folic acid 50 mg Calcium pantothenate <semantics>0.5 mg<annotation encoding="application / x-tex">0.5 \text{ mg}< / annotation>< / semantics> Minerals proper amount 10 Ferrous sulfate 1.75 mg Zinc oxide 0.82 mg Magnesium carbonate 25.3 mg Potassium phosphate, monobasic 15 mg Calcium phosphate, dibasic 55 mg 15 Potassium citrate 90 mg Calcium carbonate 100 mg Magnesium chloride 24.8 mg The vitamins and minerals appropriate for health functional foods were mixed according to the preferred 20 mixing ratio but the composition ratio can be adjusted arbitrarily. After mixing the above components according to the conventional method for preparing health functional foods, granules were prepared and the granules were used for the preparation of health 25 functional foods according to the conventional method. <Manufacturing Example 6> Preparation of health beverages Derivative represented by formula 1 500 ng Citric acid 1000 mg Oligosaccharide 100 g Maesil (Prunus mume) Extract 2 g Taurine 1 g Purified water up to 900 ml The above constituents were mixed according to the conventional method for preparing health beverages. The mixture was heated at 85°C for 1 hour with stirring and then filtered. The filtrate was loaded in sterilized containers, which were sealed and sterilized again, stored in a refrigerator until they would be used for the preparation of a composition for health beverages. The constituents appropriate for favorite beverages were mixed according to the preferred mixing ratio but the composition ratio can be adjusted according to regional and ethnic preferences such as demand class, demand country, and purpose of use, etc.

Claims

<pat:ClaimStatement>What is claimed is:

1. A compound represented by formula 1 below, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof: [Formula 1] [Image disponible dans le document PDF, Image available in the PDF document] wherein, <semantics>X1<annotation encoding="application / x-tex">X^1< / annotation>< / semantics> and <semantics>X2<annotation encoding="application / x-tex">X^2< / annotation>< / semantics> form C=C double bond by linking with the carbon atom to which they are attached; and [Image disponible dans le document PDF, Image available in the PDF document] is unsubstituted or substituted 5-6 membered heteroaryl containing at least one heteroatom selected from the group consisting of N and S, or unsubstituted or substituted phenyl, wherein the substituted 5-6 membered heteroaryl and phenyl are independently substituted with at least one substituent selected from the group consisting of: <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen or hydroxy group, <semantics>C2−7<annotation encoding="application / x-tex">C_{2-7}< / annotation>< / semantics> straight or branched alkynyl, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, 5-6 membered heterocycloalkyl containing at least one heteroatom selected from the group consisting of N and O unsubstituted or substituted with at least one <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, <semantics>−NR1R2<annotation encoding="application / x-tex">-NR^1R^2< / annotation>< / semantics>, <semantics>−OR3<annotation encoding="application / x-tex">-OR^3< / annotation>< / semantics>, <semantics>−SR4<annotation encoding="application / x-tex">-SR^4< / annotation>< / semantics>; C6 aryl unsubstituted or substituted with at least one halogen or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl; and 5 membered heteroaryl containing at least one heteroatom selected from the group consisting of N, O and S, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics> and <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics> are independently <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl, <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl substituted with C3-6 cycloalkyl unsubstituted or substituted with at least one methyl, <semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics> is <semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics> straight or branched alkyl unsubstituted or substituted with at least one halogen, <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, or <semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics> straight or branched alkyl substituted with C3-6 cycloalkyl unsubstituted or substituted with at least one methyl.

2. The compound, the stereoisomer thereof, the solvate thereof, the hydrate thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein: [Image disponible dans le document PDF, Image available in the PDF document] is substituted pyridinyl.

3. The compound, the stereoisomer thereof, the solvate thereof, the hydrate thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <semantics>a¯<annotation encoding="application / x-tex">\overline{\phantom{a}}< / annotation>< / semantics> CA 3173067 [Image disponible dans le document PDF, Image available in the PDF document] 4. The compound, the stereoisomer thereof, the solvate thereof, the hydrate thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein the compound represented by formula 1 is selected from the group consisting of the following compounds:< / pat:ClaimStatement> <pat:Claims com:id="claims"> <pat:Claim com:id="CLM-00001"> <pat:ClaimNumber>1< / pat:ClaimNumber> <pat:ClaimText>1. <semantics>(E)−3−(2−(4−methylpiperidin−1−yl)−6−(trifluoromethyl)pyridin−3−yl<annotation encoding="application / x-tex">(E) -3 - (2 - (4 - methylpiperidin - 1 - yl) -6 - (trifluoromethyl)pyridin -3 - yl< / annotation>< / semantics> )-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00002"> <pat:ClaimNumber>2< / pat:ClaimNumber> <pat:ClaimText>2. <semantics>(E)−3−(2−(4−ethylpiperidin−1−yl)−6−(trifluoromethyl)pyridin−3−yl)<annotation encoding="application / x-tex">(E) - 3 - (2 - (4 - \text{ethylpiperidin} - 1 - \text{yl}) - 6 - (\text{trifluoromethyl}) \text{pyridin} - 3 - \text{yl})< / annotation>< / semantics> -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00003"> <pat:ClaimNumber>3< / pat:ClaimNumber> <pat:ClaimText>3. <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−yl)−3−(2−(pyrrolid))<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo[d]imidazol - 4 - yl) - 3 - (2 - (pyrrolid))< / annotation>< / semantics> in-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00004"> <pat:ClaimNumber>4< / pat:ClaimNumber> <pat:ClaimText>4. <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−yl)−3−(2−(piperidi<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo [d] imidazol - 4 - yl) - 3 - (2 - (piperidi< / annotation>< / semantics> n-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00005"> <pat:ClaimNumber>5< / pat:ClaimNumber> <pat:ClaimText>5. (E) <semantics>−3−(2−morpholino−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,3)<annotation encoding="application / x-tex">-3-(2-morpholino-6-(trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3)< / annotation>< / semantics> -dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00006"> <pat:ClaimNumber>6< / pat:ClaimNumber> <pat:ClaimText>6. <semantics>(E)−3−(2−(diethylamino)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo<annotation encoding="application / x-tex">(E) -3 - (2 - (diethylamino) -6 - (trifluoromethyl)pyridin-3-yl) -N- (2-oxo< / annotation>< / semantics> -2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00007"> <pat:ClaimNumber>7< / pat:ClaimNumber> <pat:ClaimText>7. <semantics>(E)−3−(2−(dipropylamino)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−ox<annotation encoding="application / x-tex">(E) -3 - (2 - (dipropylamino) -6 - (trifluoromethyl)pyridin-3-yl)-N-(2-ox< / annotation>< / semantics> o-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00008"> <pat:ClaimNumber>8< / pat:ClaimNumber> <pat:ClaimText>8. <semantics>(E)−3−(2−butoxy−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,3−dih<annotation encoding="application / x-tex">(E) -3 - (2 - butoxy - 6 - (trifluoromethyl) pyridin - 3 - yl) - N - (2 - oxo - 2, 3 - dih< / annotation>< / semantics> ydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00009"> <pat:ClaimNumber>9< / pat:ClaimNumber> <pat:ClaimText>9. <semantics>(E)−3−(2−(hexyloxy)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,3)<annotation encoding="application / x-tex">(E) -3 - (2 - (hexyloxy) -6 - (trifluoromethyl)pyridin-3-yl)-N-(2-oxo-2,3)< / annotation>< / semantics> -dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00010"> <pat:ClaimNumber>10< / pat:ClaimNumber> <pat:ClaimText>10. <semantics>(E)−3−(2−isobutoxy−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−oxo−2,3−<annotation encoding="application / x-tex">(E) - 3 - (2 - isobutoxy - 6 - (trifluoromethyl)pyridin - 3 - yl) - N - (2 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 - oxo - 2, 3 -< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00011"> <pat:ClaimNumber>11< / pat:ClaimNumber> <pat:ClaimText>11. <semantics>(E)−3−(2−cyclobutoxy−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,<annotation encoding="application / x-tex">(E) -3 - (2 - cyclobutoxy -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - oxo -2,< / annotation>< / semantics> 3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00012"> <pat:ClaimNumber>12< / pat:ClaimNumber> <pat:ClaimText>12. <semantics>(E)−3−(2−(cyclopentyloxy)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopentyloxy) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00013"> <pat:ClaimNumber>13< / pat:ClaimNumber> <pat:ClaimText>13. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(trifluoromethyl)pyridin−3−yl)−N−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - (trifluoromethyl)pyridin -3 - yl) -N -< / annotation>< / semantics> (2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00014"> <pat:ClaimNumber>14< / pat:ClaimNumber> <pat:ClaimText>14. <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−yl)−3−(2−(2,2,2−tr))<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo[d]imidazol - 4 - yl) - 3 - (2 - (2, 2, 2 - tr))< / annotation>< / semantics> ifluoroethoxy)-6-(trifluoromethyl)pyridin-3-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00015"> <pat:ClaimNumber>15< / pat:ClaimNumber> <pat:ClaimText>15. (E) <semantics>−3−(2−(neopentyloxy)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo<annotation encoding="application / x-tex">-3-(2-(neopentyloxy)-6-(trifluoromethyl)pyridin-3-yl)-N-(2-oxo< / annotation>< / semantics> -2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00016"> <pat:ClaimNumber>16< / pat:ClaimNumber> <pat:ClaimText>16. <semantics>(E)−3−(2−((2−methylcyclopropyl)methoxy)−6−(trifluoromethyl)pyridi<annotation encoding="application / x-tex">(E) -3 - (2 - ((2 - methylcyclopropyl) methoxy) -6 - (trifluoromethyl) pyridi< / annotation>< / semantics> <semantics>n−3−y1<annotation encoding="application / x-tex">n-3-y1< / annotation>< / semantics>) <semantics>−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−y1)<annotation encoding="application / x-tex">-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-y1)< / annotation>< / semantics> acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00017"> <pat:ClaimNumber>17< / pat:ClaimNumber> <pat:ClaimText>17. <semantics>(E)−3−(6−(chlorodifluoromethyl)−2−(cyclopropylmethoxy)pyridin−3−y<annotation encoding="application / x-tex">(E) -3 - (6 - (chlorodifluoromethyl) -2 - (cyclopropylmethoxy) pyridin -3 - y< / annotation>< / semantics> 1) -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00018"> <pat:ClaimNumber>18< / pat:ClaimNumber> <pat:ClaimText>18. (E) <semantics>−3−(6−cyclopropyl−2−(cyclopropylmethoxy) pyridin−3−yl)−N−(2−oxo)<annotation encoding="application / x-tex">-3-(6-\text{cyclopropyl}-2-(\text{cyclopropylmethoxy}) \text{ pyridin}-3-\text{yl}) -N-(2-\text{oxo})< / annotation>< / semantics> -2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00019"> <pat:ClaimNumber>19< / pat:ClaimNumber> <pat:ClaimText>19. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−isopropylpyridin−3−yl)−N−(2−oxo−2)<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - isopropylpyridin -3 - yl) -N - (2 - oxo -2)< / annotation>< / semantics> ,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00020"> <pat:ClaimNumber>20< / pat:ClaimNumber> <pat:ClaimText>20. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(1−methylcyclopropyl)pyridin−3−yl<annotation encoding="application / x-tex">(E) - 3 - (2 - (cyclopropylmethoxy) - 6 - (1 - methylcyclopropyl)pyridin - 3 - yl< / annotation>< / semantics> )-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00021"> <pat:ClaimNumber>21< / pat:ClaimNumber> <pat:ClaimText>21. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(difluoromethyl)pyridin−3−yl)−N−(<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - (difluoromethyl)pyridin -3 - yl) -N - (< / annotation>< / semantics> 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00022"> <pat:ClaimNumber>22< / pat:ClaimNumber> <pat:ClaimText>22. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(1,1−difluoroethyl)pyridin−3−yl)−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - (1, 1 - difluoroethyl)pyridin -3 - yl) -< / annotation>< / semantics> N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00023"> <pat:ClaimNumber>23< / pat:ClaimNumber> <pat:ClaimText>23. <semantics>(E)−3−(6−(tert−butyl)−2−(cyclopropylmethoxy)pyridin−3−yl)−N−(2−ox<annotation encoding="application / x-tex">(E) -3 - (6 - (tert-butyl) -2 - (cyclopropylmethoxy) pyridin -3 - yl) -N - (2 - ox< / annotation>< / semantics> o-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00024"> <pat:ClaimNumber>24< / pat:ClaimNumber> <pat:ClaimText>24. <semantics>(E)−3−(2−(cyclopropylmethoxy)−6−(2−hydroxypropan−2−yl)pyridin−3−y<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -6 - (2 - hydroxypropan -2 - yl)pyridin -3 - y< / annotation>< / semantics> 1) -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00025"> <pat:ClaimNumber>25< / pat:ClaimNumber> <pat:ClaimText>25. <semantics>(E)−3−(2−(cyclobutylmethoxy)−6−(trifluoromethyl)pyridin−3−yl)−N−(<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclobutylmethoxy) -6 - (trifluoromethyl)pyridin-3-yl)-N-(< / annotation>< / semantics> 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00026"> <pat:ClaimNumber>26< / pat:ClaimNumber> <pat:ClaimText>26. <semantics>(E)−3−(2−(cyclopentylmethoxy)−6−(trifluoromethyl)pyridin−3−yl)−N−<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopentylmethoxy) -6 - (trifluoromethyl)pyridin -3 - yl) -N -< / annotation>< / semantics> (2-oxo-2, 3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00027"> <pat:ClaimNumber>27< / pat:ClaimNumber> <pat:ClaimText>27. <semantics>(E)−3−(2−(isobutylthio)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo<annotation encoding="application / x-tex">(E) -3 - (2 - (isobutylthio) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - oxo< / annotation>< / semantics> -2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00028"> <pat:ClaimNumber>28< / pat:ClaimNumber> <pat:ClaimText>28. <semantics>(E)−3−(2−((cyclopropylmethyl)thio)−6−(trifluoromethyl)pyridin−3−y<annotation encoding="application / x-tex">(E) -3 - (2 - ((cyclopropylmethyl)thio) -6 - (trifluoromethyl)pyridin -3 - y< / annotation>< / semantics> 1) -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00029"> <pat:ClaimNumber>29< / pat:ClaimNumber> <pat:ClaimText>29. <semantics>(E)−3−(2−(cyclohexylthio)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclohexylthio) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00030"> <pat:ClaimNumber>30< / pat:ClaimNumber> <pat:ClaimText>30. <semantics>(E)−3−(2−(3−fluorophenyl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (2 - (3 - fluorophenyl) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00031"> <pat:ClaimNumber>31< / pat:ClaimNumber> <pat:ClaimText>31. <semantics>(E)−3−(2−(3−chlorophenyl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (2 - (3 - chlorophenyl) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00032"> <pat:ClaimNumber>32< / pat:ClaimNumber> <pat:ClaimText>32. <semantics>(E)−3−(2−(3−isopropylphenyl)−6−(trifluoromethyl)pyridin−3−yl)−N−(<annotation encoding="application / x-tex">(E) - 3 - (2 - (3 - isopropylphenyl) - 6 - (trifluoromethyl)pyridin - 3 - yl) - N - (< / annotation>< / semantics> 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00033"> <pat:ClaimNumber>33< / pat:ClaimNumber> <pat:ClaimText>33. <semantics>(E)−3−(2−(3−chloro−4−fluorophenyl)−6−(trifluoromethyl)pyridin−3−y<annotation encoding="application / x-tex">(E)-3-(2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-y< / annotation>< / semantics> 1) -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00034"> <pat:ClaimNumber>34< / pat:ClaimNumber> <pat:ClaimText>34. <semantics>(E)−3−(2−(4−fluorophenyl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (2 - (4 - fluorophenyl) -6 - (trifluoromethyl) pyridin -3 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00035"> <pat:ClaimNumber>35< / pat:ClaimNumber> <pat:ClaimText>35. <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−yl)−3−(2−(thiophen))<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo [d] imidazol - 4 - yl) - 3 - (2 - (thiophen))< / annotation>< / semantics> -2-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00036"> <pat:ClaimNumber>36< / pat:ClaimNumber> <pat:ClaimText>36. <semantics>(E)−3−(2−(furan−2−yl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2)<annotation encoding="application / x-tex">(E) -3 - (2 - (furan -2 - yl) -6 - (trifluoromethyl) pyridin -3 - yl) -N - (2 - oxo -2)< / annotation>< / semantics> ,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00037"> <pat:ClaimNumber>37< / pat:ClaimNumber> <pat:ClaimText>37. <semantics>(E)−3−(2−(oxazol−2−yl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−<annotation encoding="application / x-tex">(E) -3 - (2 - (oxazol - 2 - yl) -6 - (trifluoromethyl) pyridin -3 - yl) -N - (2 - oxo-< / annotation>< / semantics> 2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00038"> <pat:ClaimNumber>38< / pat:ClaimNumber> <pat:ClaimText>38. <semantics>(E)−3−(2−(oxazol−5−yl)−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−<annotation encoding="application / x-tex">(E) -3 - (2 - (oxazol -5 - yl) -6 - (trifluoromethyl)pyridin -3 - yl) -N - (2 - oxo-< / annotation>< / semantics> 2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00039"> <pat:ClaimNumber>39< / pat:ClaimNumber> <pat:ClaimText>39. <semantics>(E)−3−(2−(3,3−dimethyl−1−butyn−1−yl)−6−(trifluoromethyl)pyridin−3<annotation encoding="application / x-tex">(E) -3 - (2 - (3, 3 - dimethyl - 1 - butyn - 1 - yl) -6 - (trifluoromethyl) pyridin -3< / annotation>< / semantics> -yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00040"> <pat:ClaimNumber>40< / pat:ClaimNumber> <pat:ClaimText>40. <semantics>(E)−3−(2−(3,3−dimethylbutyl)−6−(trifluoromethyl)pyridin−3−yl)−N−(<annotation encoding="application / x-tex">(E) -3 - (2 - (3, 3 - \text{dimethylbutyl}) -6 - (\text{trifluoromethyl}) \text{pyridin} -3 - \text{yl}) -N - (< / annotation>< / semantics> 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00041"> <pat:ClaimNumber>41< / pat:ClaimNumber> <pat:ClaimText>41. <semantics>(E)−3−(2−cyclopentyl−6−(trifluoromethyl)pyridin−3−yl)−N−(2−oxo−2,<annotation encoding="application / x-tex">(E) -3 - (2 - cyclopentyl - 6 - (trifluoromethyl)pyridin - 3 - yl) - N - (2 - oxo - 2,< / annotation>< / semantics> 3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00042"> <pat:ClaimNumber>42< / pat:ClaimNumber> <pat:ClaimText>42. <semantics>(E)−3−(2−isobutoxy−4−(trifluoromethyl)phenyl)−N−(2−oxo−2,3−dihydr<annotation encoding="application / x-tex">(E) -3 - (2 - isobutoxy - 4 - (trifluoromethyl) phenyl) -N - (2 - oxo - 2, 3 - dihydr< / annotation>< / semantics> o-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00043"> <pat:ClaimNumber>43< / pat:ClaimNumber> <pat:ClaimText>43. <semantics>(E)−3−(2−(cyclopropylmethoxy)−4−(trifluoromethyl)phenyl)−N−(2−oxo<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -4 - (trifluoromethyl)phenyl) -N - (2 - oxo< / annotation>< / semantics> -2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00044"> <pat:ClaimNumber>44< / pat:ClaimNumber> <pat:ClaimText>44. <semantics>(E)−3−(2−(cyclopropylmethoxy)−4−(2−hydroxypropan−2−yl)phenyl)−N−(<annotation encoding="application / x-tex">(E) -3 - (2 - (cyclopropylmethoxy) -4 - (2 - hydroxypropan -2 - yl)phenyl) -N - (< / annotation>< / semantics> 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00045"> <pat:ClaimNumber>45< / pat:ClaimNumber> <pat:ClaimText>45. <semantics>(E)−3−(4−(tert−butyl)−2−(cyclopropylmethoxy)phenyl)−N−(2−oxo−2,3−1)<annotation encoding="application / x-tex">(E) -3 - (4 - (tert-butyl) -2 - (cyclopropylmethoxy) phenyl) -N - (2 - oxo - 2, 3 - 1)< / annotation>< / semantics> dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00046"> <pat:ClaimNumber>46< / pat:ClaimNumber> <pat:ClaimText>46. <semantics>(E)−3−(4−cyclopropyl−2−(cyclopropylmethoxy)phenyl)−N−(2−oxo−2,3−d)<annotation encoding="application / x-tex">(E) -3 - (4 - cyclopropyl - 2 - (cyclopropyl methoxy) phenyl) - N - (2 - oxo - 2, 3 - d)< / annotation>< / semantics> ihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00047"> <pat:ClaimNumber>47< / pat:ClaimNumber> <pat:ClaimText>47. <semantics>(E)−3−(1−(3−chlorophenyl)−3−(trifluoromethyl)−1H−pyrazol−5−yl)−N−<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - chlorophenyl) -3 - (trifluoromethyl) -1H-pyrazol-5-yl) -N-< / annotation>< / semantics> (2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00048"> <pat:ClaimNumber>48< / pat:ClaimNumber> <pat:ClaimText>48. <semantics>(E)−N−(2−oxo−2,3−dihydro−1H−benzo[d]imidazol−4−yl)−3−(1−(m−tolyl))<annotation encoding="application / x-tex">(E) - N - (2 - oxo - 2, 3 - dihydro - 1H - benzo[d]imidazol - 4 - yl) - 3 - (1 - (m - tolyl))< / annotation>< / semantics> -3-(trifluoromethyl)-1H-pyrazol-5-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00049"> <pat:ClaimNumber>49< / pat:ClaimNumber> <pat:ClaimText>49. <semantics>(E)−3−(1−(3−chloro−4−fluorophenyl)−3−(trifluoromethyl)−1H−pyrazol<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - chloro - 4 - fluorophenyl) -3 - (trifluoromethyl) -1H-pyrazol< / annotation>< / semantics> -5-yl)-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00050"> <pat:ClaimNumber>50< / pat:ClaimNumber> <pat:ClaimText>50. <semantics>(E)−3−(1−(3−isopropylphenyl)−3−(trifluoromethyl)−1H−pyrazol−5−yl)<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - isopropylphenyl) -3 - (trifluoromethyl) -1H-pyrazol-5-yl)< / annotation>< / semantics> -N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00051"> <pat:ClaimNumber>51< / pat:ClaimNumber> <pat:ClaimText>51. <semantics>(E)−3−(1−(3−chlorophenyl)−3−isopropyl−1H−pyrazol−5−yl)−N−(2−oxo−2)<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - chlorophenyl) -3 - isopropyl - 1H - pyrazol -5 - yl) -N - (2 - oxo - 2)< / annotation>< / semantics> ,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00052"> <pat:ClaimNumber>52< / pat:ClaimNumber> <pat:ClaimText>52. <semantics>(E)−3−(1−(3−chlorophenyl)−3−(1−methylcyclopropyl)−1H−pyrazol−5−yl<annotation encoding="application / x-tex">(E) -3 - (1 - (3 - chlorophenyl) -3 - (1 - methylcyclopropyl) -1H-pyrazol-5-yl< / annotation>< / semantics> )-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00053"> <pat:ClaimNumber>53< / pat:ClaimNumber> <pat:ClaimText>53. <semantics>(E)−3−(3−(tert−butyl)−1−(3−chlorophenyl)−1H−pyrazol−5−yl)−N−(2−oxidenyl)<annotation encoding="application / x-tex">(E)-3-(3-(tert-butyl)-1-(3-chlorophenyl)-1H-pyrazol-5-yl)-N-(2-oxidenyl)< / annotation>< / semantics> o-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00054"> <pat:ClaimNumber>54< / pat:ClaimNumber> <pat:ClaimText>54. <semantics>(E)−3−(4−(3−chlorophenyl)−2−(trifluoromethyl)thiazol−5−yl)−N−(2−o<annotation encoding="application / x-tex">(E) -3 - (4 - (3 - chlorophenyl) -2 - (trifluoromethyl) thiazol -5 - yl) -N - (2 - o< / annotation>< / semantics> xo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00055"> <pat:ClaimNumber>55< / pat:ClaimNumber> <pat:ClaimText>55. <semantics>(E)−3−(4−(3−chlorophenyl)−2−isopropylthiazol−5−yl)−N−(2−oxo−2,3−d)<annotation encoding="application / x-tex">(E) -3 - (4 - (3 - chlorophenyl) -2 - isopropylthiazol -5 - yl) -N - (2 - oxo - 2, 3 - d)< / annotation>< / semantics> ihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00056"> <pat:ClaimNumber>56< / pat:ClaimNumber> <pat:ClaimText>56. (E) <semantics>−3−(4−(3−chlorophenyl)−2−cyclopropylthiazol−5−yl)−N−(2−oxo−2,3)<annotation encoding="application / x-tex">-3-(4-(3-\text{chlorophenyl})-2-\text{cyclopropylthiazol}-5-\text{yl})-N-(2-\text{oxo}-2,3)< / annotation>< / semantics> -dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00057"> <pat:ClaimNumber>57< / pat:ClaimNumber> <pat:ClaimText>57. <semantics>(E)−3−(4−(3−chlorophenyl)−2−(1−methylcyclopropyl)thiazol−5−yl)−N−<annotation encoding="application / x-tex">(E) -3 - (4 - (3 - chlorophenyl) -2 - (1 - methylcyclopropyl) thiazol -5 - yl) -N-< / annotation>< / semantics> (2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide; and < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00058"> <pat:ClaimNumber>58< / pat:ClaimNumber> <pat:ClaimText>58. <semantics>(E)−3−(2−(tert−butyl)−4−(3−chlorophenyl)thiazol−5−yl)−N−(2−oxo−2,<annotation encoding="application / x-tex">(E) -3 - (2 - (tert-butyl) -4 - (3 - chlorophenyl) thiazol-5-yl) -N-(2-oxo-2,< / annotation>< / semantics> 3-dihydro-1H-benzo[d]imidazol-4-yl)acrylamide.

5. A pharmaceutical kit for treating pain comprising a first component containing the compound of claim 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof; and a second component containing an analgesic.

6. Use of the compound represented by formula 1 of claim 1, a solvate thereof or a pharmaceutically acceptable salt thereof for treating or alleviating pain.

7. The use according to claim 6, wherein the compound exhibits a therapeutic activity for pain by inhibiting TRPV1 (transient receptor potential vanilloid-1) receptor activators.

8. The use according to claim 6, wherein the compound treating or alleviates pain by suppressing capsaicin, a TRPV1 (transient receptor potential vanilloid-1) receptor activator, and inhibits pH in the range of 20% to 80% to reduce side effects of abnormal body temperature. < / pat:ClaimText> < / pat:Claim> < / pat:Claims>