Ionizable lipid compounds

Abstract

Provided herein is a class of ionizable lipid compounds represented by formula (IV), or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids. [Image disponible dans le document PDF, Image available in the PDF document]

Description

IONIZABLE LIPID COMPOUNDS CROSS REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims the priority of the Chinese Patent Application No. 202210478559.X filed on April 29, 2022, Chinese Patent Application No. 202210478132.X filed on April 29, 2022, Chinese Patent Application No. 202211319669.8 filed on October 26, 2022, and Chinese Patent Application No. 202211419893.4 filed on November 14, 2022. FIELD OF THE INVENTION

[0002] The present disclosure relates to a new class of ionizable cationic lipid compounds, or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. The present disclosure also relates to lipid nanoparticles and pharmaceutical compositions comprising said compound, and the application of the lipid nanoparticles in the delivery of biologically active substances such as nucleic acids (e.g., mRNA, miRNA, siRNA, saRNA, ASO, and DNA, etc.). BACKGROUND OF THE INVENTION

[0003] Gene therapy refers to the introduction of exogenous genes into target cells to correct or compensate for genetic defects or abnormalities within the cell, so as to achieve the purpose of treatment. In the past few decades, research related to the treatment of clinical diseases through gene therapy has received more and more attention. Especially in recent years, siRNA-related drugs and mRNA vaccines have been approved by the FDA for clinical treatment, which has further promoted research and related investment in the field of gene therapy.

[0004] Nucleic acid substances are easily degraded by nucleases in organisms, and nucleic acid substances themselves are negatively charged, which makes it difficult for them to enter the cell through the cell membrane. As a nucleic acid delivery material, lipid nanoparticles (LNP) are one of the most important nucleic acid delivery systems with the advantages of easy to prepare, good biodegradability, no immunogenicity and good safety.

[0005] The nucleic acid vaccine developed by Moderna and BioNTech uses LNP as the delivery system, and the main components of LNP include cationic lipids, cholesterol, neutral lipids and polyethylene glycol-conjugated lipids. Among them, cationic lipid molecules are the core of LNP delivery system, and their molecular structure plays a decisive role in the delivery efficiency, targeting, and formulation stability, and the like, of the entire liposome nanoparticles.

[0006] Due to the different requirements of the delivery system for the delivery of different kinds of nucleic acid substances and the specific delivery of different targets, in order to meet the different needs of gene therapy, new lipid molecules need to be further developed. SUMMARY OF THE INVENTION

[0007] The present disclosure develops a new class of ionizable cationic lipid compounds that can be used to deliver various biologically active substances with high delivery efficiency.

[0008] In one aspect, the present disclosure provides a compound of formula (IV), or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document]

[0009] wherein,

[0010] M<com:Sub>1< / com:Sub> and M<com:Sub>2< / com:Sub> are independently selected from -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>a< / com:Sub>-, <com:Math><semantics>−NRaC(O)NRa<annotation encoding="application / x-tex">-NR_aC(O)NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)S<annotation encoding="application / x-tex">-OC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRaC(O)O<annotation encoding="application / x-tex">-NR_aC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRa<annotation encoding="application / x-tex">-NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRa<annotation encoding="application / x-tex">-C(O)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)<annotation encoding="application / x-tex">-NR_{a}C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)S<annotation encoding="application / x-tex">-NR_{a}C(O)S< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)NRa<annotation encoding="application / x-tex">-SC(O)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(S)NRa<annotation encoding="application / x-tex">-OC(S)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(S)O−,−S−S− and −S(O)0−2−;<annotation encoding="application / x-tex">-NR_aC(S)O_{-}, -S_{-}S_{-} \text{ and } -S(O)_{0-2}_{-};< / annotation>< / semantics>< / com:Math>

[0011] Q is selected from a chemical bond, -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>b< / com:Sub>-, <com:Math><semantics>−NRbC(O)NRb<annotation encoding="application / x-tex">-NR_bC(O)NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)S<annotation encoding="application / x-tex">-OC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)O<annotation encoding="application / x-tex">-NR_bC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRb<annotation encoding="application / x-tex">-NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRb−<annotation encoding="application / x-tex">-C(O)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(O)<annotation encoding="application / x-tex">-NR_{b}C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)S<annotation encoding="application / x-tex">-NR_{b}C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)NRb−<annotation encoding="application / x-tex">-SC(O)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)NRb−<annotation encoding="application / x-tex">-OC(S)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(S)O−<annotation encoding="application / x-tex">-NR_bC(S)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−S−<annotation encoding="application / x-tex">-S_{-}S_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)0−2<annotation encoding="application / x-tex">-S(O)_{0-2}< / annotation>< / semantics>< / com:Math>, phenylene and pyridylidene, wherein, the phenylene or pyridylidene is optionally substituted with one or more R*;

[0012] <com:Math><semantics>G5<annotation encoding="application / x-tex">G_5< / annotation>< / semantics>< / com:Math> is a chemical bond or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with one or more R**;

[0013] <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with one or more R**;

[0014] <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 0, 1, 2, 3, 4, 5, 6 or 7 carbon atoms;

[0015] R<com:Sub>9< / com:Sub>, R<com:Sub>10< / com:Sub> and R** are independently H, C<com:Sub>1-8< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>, -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>;

[0016] G<com:Sub>1< / com:Sub>, G<com:Sub>2< / com:Sub>, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> are independently a chemical bond, C<com:Sub>1-13< / com:Sub> alkylene, C<com:Sub>2-13< / com:Sub> alkenylene or C<com:Sub>2-13< / com:Sub> alkynylene, which is optionally substituted with one or more R<com:Sup>s< / com:Sup>;

[0017] G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[0018] G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[0019] <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are independently H, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl, <com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*:

[0020] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 14-membered heterocyclyl, which is optionally substituted with one or more R*;

[0021] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*;

[0022] R* is independently H, halogen, cyano, C<com:Sub>1-10< / com:Sub> alkyl, C<com:Sub>1-10< / com:Sub> haloalkyl, -L<com:Sub>b< / com:Sub>-OR<com:Sub>b< / com:Sub>, -L<com:Sub>b< / com:Sub>-SR<com:Sub>b< / com:Sub> or -L<com:Sub>b< / com:Sub>-NR<com:Sub>b< / com:Sub>R'<com:Sub>b< / com:Sub>;

[0023] <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, which is optionally substituted with one or more R*;

[0024] <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl, which is optionally substituted with one or more R, and wherein one or more methylene units are optionally and independently replaced with -NR''-;

[0025] R<com:Sup>s< / com:Sup> is independently H, C<com:Sub>1-14< / com:Sub> alkyl, -L<com:Sub>d< / com:Sub>-OR<com:Sub>d< / com:Sub>, -L<com:Sub>d< / com:Sub>-SR<com:Sub>d< / com:Sub> or -L<com:Sub>d< / com:Sub>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>;

[0026] R is independently H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>a< / com:Sub>-OR<com:Sub>a< / com:Sub>, -L<com:Sub>a< / com:Sub>-SR<com:Sub>a< / com:Sub> or -L<com:Sub>a< / com:Sub>-NR<com:Sub>a< / com:Sub>R'<com:Sub>a< / com:Sub>;

[0027] R'' is independently H or <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl;

[0028] <com:Math><semantics>La<annotation encoding="application / x-tex">L_a< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Le<annotation encoding="application / x-tex">L_e< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkylene;

[0029] <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene;

[0030] L<com:Sub>c< / com:Sub> is independently a chemical bond or C<com:Sub>1-8< / com:Sub> alkylene;

[0031] <com:Math><semantics>Ld<annotation encoding="application / x-tex">L_d< / annotation>< / semantics>< / com:Math> is independently a chemical bond or <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkylene;

[0032] R<com:Sub>a< / com:Sub> and R'<com:Sub>a< / com:Sub> are independently selected from H, C<com:Sub>1-20< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>e< / com:Sub>-OR<com:Sub>e< / com:Sub>, -L<com:Sub>e< / com:Sub>-SR<com:Sub>e< / com:Sub> and -L<com:Sub>e< / com:Sub>-NR<com:Sub>e< / com:Sub>R'<com:Sub>e< / com:Sub>;

[0033] R<com:Sub>b< / com:Sub> and R'<com:Sub>b< / com:Sub> are independently selected from H, C<com:Sub>1-10< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>f< / com:Sub>-OR<com:Sub>f< / com:Sub>, -L<com:Sub>f< / com:Sub>-SR<com:Sub>f< / com:Sub> and -L<com:Sub>f< / com:Sub>-NR<com:Sub>f< / com:Sub>R'<com:Sub>f< / com:Sub>;

[0034] <com:Math><semantics>Rc<annotation encoding="application / x-tex">R_c< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rc′<annotation encoding="application / x-tex">R'_c< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl;

[0035] <com:Math><semantics>Rd<annotation encoding="application / x-tex">R_d< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rd′<annotation encoding="application / x-tex">R'_d< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl;

[0036] R<com:Sub>e< / com:Sub> and R'<com:Sub>e< / com:Sub> are independently H or C<com:Sub>1-20< / com:Sub> alkyl;

[0037] <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rf′<annotation encoding="application / x-tex">R'_f< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl.

[0038] In another aspect, the present disclosure provides a nanoparticle composition, the nanoparticle composition comprises lipid components, and optionally comprises a load; wherein, the lipid component comprises the compounds of the present disclosure.

[0039] US11246933B1 discloses that the incorporation of the biodegradable group(s) into the tail chain of a lipid compound in a lipid nanoparticle results in faster metabolism and removal of the lipid from the body following delivery of the active agent to a target area. As a result, these lipids which contain the biodegradable groups have lower toxicity than similar lipids without the biodegradable groups. The tail chain of the cationic lipid compound of the present disclosure has biodegradable group(s), thereby has superior toxicity profile to similar lipids without biodegradable groups, such as DLin-MC3-DMA.

[0040] In another aspect, the present disclosure provides a pharmaceutical composition comprising a compound of the present disclosure or a nanoparticle composition of the present disclosure, and optionally pharmaceutically acceptable excipient(s), such as carrier(s), adjuvant(s) or vehicle(s).

[0041] In another aspect, the present disclosure provides the use of a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure in the manufacture of a medicament for treating, diagnosing, or preventing a disease.

[0042] In another aspect, the present disclosure provides the use of a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure in the manufacture of a medicament for deliverying a load.

[0043] In another aspect, the present disclosure provides a method of treating, diagnosing, or preventing a disease in a subject, comprising administering to the subject a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure.

[0044] In another aspect, the present disclosure provides a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure, for use in treating, diagnosing, and / or preventing a disease.

[0045] In another aspect, the present disclosure provides a method of delivering a load in a subject, comprising administering to the subject a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure.

[0046] In another aspect, the present disclosure provides a compound of the present disclosure, a nanoparticle composition of the present disclosure, or a pharmaceutical composition of the present disclosure, for use in delivering a load.

[0047] In a specific embodiment, the load is one or more of therapeutic agents, prophylactic agents, or diagnostic agents; alternatively, the therapeutic agent, prophylactic agent, or diagnostic agent is a nucleic acid.

[0048] In a more specific embodiment, the nucleic acid is one or more of ASO, RNA or DNA.

[0049] In a more specific embodiment, the RNA is selected from one or more of interfering RNA (RNAi), small interfering RNA (siRNA), short hairpin RNA (shRNA), antisense RNA (aRNA), messenger RNA (mRNA), modified messenger RNA (mmRNA), long non-coding RNA (lncRNA), microRNA (miRNA), small activating RNA (saRNA), multimeric coding nucleic acid (MCNA), polymeric coding nucleic acid (PCNA), guide RNA (gRNA), CRISPRRNA (crRNA) and nucleases, alternatively mRNA, more alternatively modified mRNA. TERMINOLOGY Chemical terminology

[0050] Terminology of specific functional groups and chemical terms are described in more detail below.

[0051] When a range of values is listed, it is intended to encompass each value and sub-range within the range. For example, "C<com:Sub>1-6< / com:Sub> alkyl" is intended to include C<com:Sub>1< / com:Sub>, C<com:Sub>2< / com:Sub>, C<com:Sub>3< / com:Sub>, C<com:Sub>4< / com:Sub>, C<com:Sub>5< / com:Sub>, C<com:Sub>6< / com:Sub>, C<com:Sub>1-6< / com:Sub>, C<com:Sub>1-5< / com:Sub>, C<com:Sub>1-4< / com:Sub>, C<com:Sub>1-3< / com:Sub>, C<com:Sub>1-2< / com:Sub>, C<com:Sub>2-6< / com:Sub>, C<com:Sub>2-5< / com:Sub>, C<com:Sub>2-4< / com:Sub>, C<com:Sub>2-3< / com:Sub>, C<com:Sub>3-6< / com:Sub>, C<com:Sub>3-5< / com:Sub>, C<com:Sub>3-4< / com:Sub>, C<com:Sub>4-6< / com:Sub>, C<com:Sub>4-5< / com:Sub> and C<com:Sub>5-6< / com:Sub> alkyl.

[0052] "C<com:Sub>1-28< / com:Sub> alkyl" refers to a radical of a linear or branched, saturated hydrocarbon group having 1 to 28 carbon atoms. In some embodiments, C<com:Sub>4-28< / com:Sub> alkyl, C<com:Sub>4-24< / com:Sub> alkyl, C<com:Sub>4-20< / com:Sub> alkyl, C<com:Sub>8-10< / com:Sub> alkyl, <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C7−9<annotation encoding="application / x-tex">C_{7-9}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C4−6<annotation encoding="application / x-tex">C_{4-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−14<annotation encoding="application / x-tex">C_{2-14}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−13<annotation encoding="application / x-tex">C_{1-13}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−7<annotation encoding="application / x-tex">C_{2-7}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C2−3<annotation encoding="application / x-tex">C_{2-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−2<annotation encoding="application / x-tex">C_{1-2}< / annotation>< / semantics>< / com:Math> alkyl and Me are alternative. Examples of <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl include methyl (C<com:Sub>1< / com:Sub>), ethyl (C<com:Sub>2< / com:Sub>), n-propyl (C<com:Sub>3< / com:Sub>), iso-propyl (C<com:Sub>3< / com:Sub>), n-butyl (C<com:Sub>4< / com:Sub>), tert-butyl (C<com:Sub>4< / com:Sub>), sec-butyl (C<com:Sub>4< / com:Sub>), iso-butyl (C<com:Sub>4< / com:Sub>), n-pentyl (C<com:Sub>5< / com:Sub>), 3-pentyl (C<com:Sub>5< / com:Sub>), pentyl (C<com:Sub>5< / com:Sub>), neopentyl (C<com:Sub>5< / com:Sub>), 3-methyl-2-butyl (<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>), tert-pentyl (<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>) and n-hexyl (<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>). The term "<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl" also includes heteroalkyl, wherein one or more (e.g., 1, 2, 3 or 4) carbon atoms are substituted with heteroatoms (e.g., oxygen, sulfur, nitrogen, boron, silicon, phosphorus). Alkyl groups can be optionally substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent. Conventional abbreviations of alkyl include Me (-CH<com:Sub>3< / com:Sub>), Et (-CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>), iPr (-CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>), nPr (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>), n-Bu (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>) or i-Bu <com:Math><semantics>(−CH2CH(CH3)2).<annotation encoding="application / x-tex">(-CH2CH(CH3)2).< / annotation>< / semantics>< / com:Math>

[0053] "C<com:Sub>2-20< / com:Sub> alkenyl" refers to a radical of a linear or branched hydrocarbon group having 2 to 20 carbon atoms and at least one carbon-carbon double bond. "C<com:Sub>4-28< / com:Sub> alkenyl" refers to a radical of a linear or branched hydrocarbon group having 4 to 28 carbon atoms and at least one carbon-carbon double bond. In some embodiments, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkenyl, and <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkenyl is alternative. Examples of <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkenyl include vinyl <com:Math><semantics>(C2)<annotation encoding="application / x-tex">(C_2)< / annotation>< / semantics>< / com:Math>, 1-propenyl <com:Math><semantics>(C3)<annotation encoding="application / x-tex">(C_3)< / annotation>< / semantics>< / com:Math>, 2-propenyl <com:Math><semantics>(C3)<annotation encoding="application / x-tex">(C_3)< / annotation>< / semantics>< / com:Math>, 1-butenyl <com:Math><semantics>(C4)<annotation encoding="application / x-tex">(C_4)< / annotation>< / semantics>< / com:Math>, 2-butenyl <com:Math><semantics>(C4)<annotation encoding="application / x-tex">(C_4)< / annotation>< / semantics>< / com:Math>, butadienyl <com:Math><semantics>(C4)<annotation encoding="application / x-tex">(C_4)< / annotation>< / semantics>< / com:Math>, pentenyl (<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>), pentadienyl (<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>), hexenyl (<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>), etc. The term "<com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkenyl" also includes heteroalkenyl, wherein one or more (e.g., 1, 2, 3 or 4) carbon atoms are replaced by heteroatoms (e.g., oxygen, sulfur, nitrogen, boron, silicon, phosphorus). The alkenyl groups can be optionally substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0054] "C<com:Sub>2-20< / com:Sub> alkynyl" refers to a radical of a linear or branched hydrocarbon group having 2 to 20 carbon atoms, at least one carbon-carbon triple bond and optionally one or more carbon-carbon double bonds. "C<com:Sub>4-28< / com:Sub> alkynyl" refers to a radical of a linear or branched hydrocarbon group having 4 to 28 carbon atoms, at least one carbon-carbon triple bond and optionally one or more carbon-carbon double bonds. In some embodiments, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl, C<com:Sub>2-13< / com:Sub> alkynyl, C<com:Sub>2-10< / com:Sub> alkynyl, C<com:Sub>2-6< / com:Sub> alkynyl, and C<com:Sub>2-4< / com:Sub> alkynyl is alternative. Examples of C<com:Sub>2-6< / com:Sub> alkynyl include, but are not limited to, ethynyl (C<com:Sub>2< / com:Sub>), 1-propynyl (C<com:Sub>3< / com:Sub>), 2-propynyl (C<com:Sub>3< / com:Sub>), 1-butynyl (<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>), 2-butynyl (<com:Math><semantics>C4<annotation encoding="application / x-tex">C_4< / annotation>< / semantics>< / com:Math>), pentynyl (<com:Math><semantics>C5<annotation encoding="application / x-tex">C_5< / annotation>< / semantics>< / com:Math>), hexynyl (<com:Math><semantics>C6<annotation encoding="application / x-tex">C_6< / annotation>< / semantics>< / com:Math>), etc. The term "<com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkynyl" also includes heteroalkynyl, wherein one or more (e.g., 1, 2, 3 or 4) carbon atoms are replaced by heteroatoms (e.g., oxygen, sulfur, nitrogen, boron, silicon, phosphorus). The alkynyl groups can be substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0055] "C<com:Sub>1-20< / com:Sub> alkylene" refers to a divalent group formed by removing another hydrogen of the <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl, and can be substituted or unsubstituted. In some embodiments, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkylene, C<com:Sub>8-10< / com:Sub> alkylene, C<com:Sub>2-8< / com:Sub> alkylene, C<com:Sub>7-9< / com:Sub> alkylene, C<com:Sub>4-6< / com:Sub> alkylene, C<com:Sub>1-20< / com:Sub> alkylene, C<com:Sub>1-14< / com:Sub> alkylene, C<com:Sub>2-14< / com:Sub> alkylene, C<com:Sub>1-13< / com:Sub> alkylene, C<com:Sub>1-12< / com:Sub> alkylene, C<com:Sub>1-10< / com:Sub> alkylene, C<com:Sub>1-8< / com:Sub> alkylene, C<com:Sub>1-7< / com:Sub> alkylene, C<com:Sub>2-7< / com:Sub> alkylene, C<com:Sub>1-6< / com:Sub> alkylene, C<com:Sub>1-5< / com:Sub> alkylene, C<com:Sub>5< / com:Sub> alkylene, C<com:Sub>1-4< / com:Sub> alkylene, C<com:Sub>2-4< / com:Sub> alkylene, C<com:Sub>1-3< / com:Sub> alkylene, C<com:Sub>2-3< / com:Sub> alkylene, C<com:Sub>1-2< / com:Sub> alkylene, and methylene are alternative. The unsubstituted alkylene groups include, but are not limited to, methylene (-CH<com:Sub>2< / com:Sub>-), ethylene (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>-), propylene (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>-), butylene (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>-), pentylene (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>-), hexylene (-CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>-), etc. Examples of substituted alkylene groups, such as those substituted with one or more alkyl (methyl) groups, include, but are not limited to, substituted methylene (-CH(CH<com:Sub>3< / com:Sub>)-, -C(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>-), substituted ethylene (-CH(CH<com:Sub>3< / com:Sub>)CH<com:Sub>2< / com:Sub>-, -CH<com:Sub>2< / com:Sub>CH(CH<com:Sub>3< / com:Sub>)-, <com:Math><semantics>−C(CH3)2CH2−<annotation encoding="application / x-tex">-C(CH_3)_2CH_2-< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−CH2C(CH3)2−),<annotation encoding="application / x-tex">-CH_2C(CH_3)_2-),< / annotation>< / semantics>< / com:Math> substituted propylene <com:Math><semantics>(−CH(CH3)CH2CH2−,<annotation encoding="application / x-tex">(-CH(CH_3)CH_2CH_2-,< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document]

[0056] "<com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenylene" refers to a <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenyl group wherein another hydrogen is removed to provide a divalent radical of alkenylene, and which may be substituted or unsubstituted. In some embodiments, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkenyl, and <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkenylene is yet alternative. Exemplary unsubstituted alkenylene groups include, but are not limited to, ethylene (-CH=CH-) and propenylene (e.g., -CH=CHCH<com:Sub>2< / com:Sub>-, -CH<com:Sub>2< / com:Sub>-CH=CH-). Exemplary substituted alkenylene groups, e.g., substituted with one or more alkyl (methyl) groups, include but are not limited to, substituted ethylene (-C(CH<com:Sub>3< / com:Sub>)=CH-, -CH=C(CH<com:Sub>3< / com:Sub>)-), substituted propylene (e.g., -C(CH<com:Sub>3< / com:Sub>)=CHCH<com:Sub>2< / com:Sub>-, -CH=C(CH<com:Sub>3< / com:Sub>)CH<com:Sub>2< / com:Sub>-, -CH=CHCH(CH<com:Sub>3< / com:Sub>)-, -CH=CHC(CH<com:Math><semantics>3<annotation encoding="application / x-tex">_3< / annotation>< / semantics>< / com:Math>)<com:Math><semantics>2<annotation encoding="application / x-tex">_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CH(CH3)−CH=CH−<annotation encoding="application / x-tex">-CH(CH_3)-CH=CH-< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−C(CH3)2−CH=CH−<annotation encoding="application / x-tex">-C(CH_3)_2-CH=CH_{-}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−CH2−C(CH3)=CH−<annotation encoding="application / x-tex">-CH_2-C(CH_3)=CH_{-}< / annotation>< / semantics>< / com:Math> -CH<com:Sub>2< / com:Sub>-CH=<com:Math><semantics>C(CH3)<annotation encoding="application / x-tex">C(CH_3)< / annotation>< / semantics>< / com:Math>-), and the like.

[0057] "<com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene" refers to a <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynyl group wherein another hydrogen is removed to provide a divalent radical of alkynylene, and which may be substituted or unsubstituted. In some embodiments, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynylene, <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkynylene, and <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkynylene is yet alternative. Exemplary alkynylene groups include, but are not limited to, ethynylene (-C<com:Math><semantics>≡<annotation encoding="application / x-tex">\equiv< / annotation>< / semantics>< / com:Math>C-), substituted or unsubstituted propynylene (-C<com:Math><semantics>≡<annotation encoding="application / x-tex">\equiv< / annotation>< / semantics>< / com:Math>CCH<com:Sub>2< / com:Sub>-), and the like.

[0058] "<com:Math><semantics>C0−6<annotation encoding="application / x-tex">C_{0-6}< / annotation>< / semantics>< / com:Math> alkylene" refers to the chemical bond and the "<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene" described above, "<com:Math><semantics>C0−4<annotation encoding="application / x-tex">C_{0-4}< / annotation>< / semantics>< / com:Math> alkylene" refers to the chemical bond and the "<com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene" described above.

[0059] The term "variable A and variable B have a total length of x carbon atoms" means that the total number of carbon atoms of the main chain in the group represented by variable A and the number of carbon atoms of the main chain in the group represented by variable B is Χ.

[0060] "Halo" or "halogen" refers to fluorine (F), chlorine (Cl), bromine (Br) and iodine (I).

[0061] Thus, "<com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl" refers to the above "<com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl", which is substituted by one or more halogen. In some embodiments, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl and <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> haloalkyl is yet alternative, and still alternatively C<com:Sub>1-2< / com:Sub> haloalkyl. Exemplary haloalkyl groups include, but are not limited to, -CF<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -CHF<com:Sub>2< / com:Sub>, -CHFCH<com:Sub>2< / com:Sub>F, -CH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -CF<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -CCl<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>Cl, -CHCl<com:Sub>2< / com:Sub>, 2,2,2-trifluoro-1,1-dimethyl-ethyl, and the like. The haloalkyl can be substituted at any available point of attachment, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0062] "C<com:Sub>3-14< / com:Sub> cycloalkyl" or "3- to 14-membered cycloalkyl" refers to a radical of a non-aromatic cyclic hydrocarbon group having from 3 to 14 ring carbon atoms and zero heteroatoms, optionally wherein 1, 2 or 3 double or triple bonds are contained. In some embodiments, 3- to 10-membered cycloalkyl, 5- to 10-membered cycloalkyl, 3- to 8-membered cycloalkyl, 3- to 7-membered cycloalkyl, 3- to 6-membered cycloalkylare yet alternative, and still alternatively 5- to 7-membered cycloalkyl, 4- to 6-membered cycloalkyl, 5- to 6-membered cycloalkyl, 5-membered cycloalkyl, and 6-membered cycloalkyl. The cycloalkyl also includes a ring system in which the cycloalkyl ring described above is fused with one or more aryl or heteroaryl groups, wherein the point of attachment is on the cycloalkyl ring, and in such case, the number of carbon atoms continues to represent the number of carbon atoms in the cycloalkyl system. The cycloalkyl further comprises the cycloalkyl described above, in which the substituents on any non-adjacent carbon atoms are connected to form a bridged ring, together forming a polycyclic alkane sharing two or more carbon atoms. The cycloalkyl further comprises the cycloalkyl described above, in which the substituents on the same carbon atom are connected to form a ring, together forming a polycyclic alkane sharing one carbon atom. Exemplary cycloalkyl groups include, but are not limited to, cyclopropyl <com:Math><semantics>(C3)<annotation encoding="application / x-tex">(C_3)< / annotation>< / semantics>< / com:Math>, cyclopropenyl <com:Math><semantics>(C3)<annotation encoding="application / x-tex">(C_3)< / annotation>< / semantics>< / com:Math>, cyclobutyl <com:Math><semantics>(C4)<annotation encoding="application / x-tex">(C_4)< / annotation>< / semantics>< / com:Math>, cyclobutenyl <com:Math><semantics>(C4)<annotation encoding="application / x-tex">(C_4)< / annotation>< / semantics>< / com:Math>, cyclopentyl <com:Math><semantics>(C5)<annotation encoding="application / x-tex">(C_5)< / annotation>< / semantics>< / com:Math>, cyclopentenyl <com:Math><semantics>(C5)<annotation encoding="application / x-tex">(C_5)< / annotation>< / semantics>< / com:Math>, cyclohexyl <com:Math><semantics>(C6)<annotation encoding="application / x-tex">(C_6)< / annotation>< / semantics>< / com:Math>, cyclohexenyl <com:Math><semantics>(C6)<annotation encoding="application / x-tex">(C_6)< / annotation>< / semantics>< / com:Math>, cyclohexadienyl (C<com:Sub>6< / com:Sub>), cycloheptyl (C<com:Sub>7< / com:Sub>), cycloheptenyl (C<com:Sub>7< / com:Sub>), cycloheptadienyl (C<com:Sub>7< / com:Sub>), cycloheptatrienyl (C<com:Sub>7< / com:Sub>), etc. The cycloalkyl can be substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0063] "C<com:Sub>3-10< / com:Sub> cycloalkylene" refers to a divalent radical formed by removing another hydrogen of C<com:Sub>3-10< / com:Sub> cycloalkyl group and may be substituted or unsubstituted. In some embodiments, C<com:Sub>3-6< / com:Sub> cycloalkylene and C<com:Sub>3-4< / com:Sub> cycloalkylene groups are particularly alternative, especially alternatively cyclopropylene.

[0064] "3- to 14-membered heterocyclyl" refers to a saturated or unsaturated radical of 3- to 14-membered non-aromatic ring system having ring carbon atoms and 1 to 5 ring heteroatoms, wherein each of the heteroatoms is independently selected from nitrogen, oxygen, sulfur, boron, phosphorus and silicon, optionally wherein 1, 2 or 3 double or triple bonds are contained. In the heterocyclyl containing one or more nitrogen atoms, the point of attachment can be a carbon or nitrogen atom as long as the valence permits. In some embodiments, 3- to 10-membered heterocyclyl is alternative, which is a radical of 3- to 10-membered non-aromatic ring system having ring carbon atoms and 1 to 5 ring heteroatoms; in some embodiments, 5- to 10-membered heterocyclyl is alternative, which is a radical of 5- to 10-membered non-aromatic ring system having ring carbon atoms and 1 to 5 ring heteroatoms; in some embodiments, 3- to 8-membered heterocyclyl is alternative, which is a radical of 3- to 8-membered non-aromatic ring system having ring carbon atoms and 1 to 4 ring heteroatoms; in some embodiments, 3- to 7-membered heterocyclyl is alternative, which is a radical of 3- to 7-membered non-aromatic ring system having ring carbon atoms and 1 to 4 ring heteroatoms; 5- to 7-membered heterocyclyl is alternative, which is a radical of 5- to 7-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms; 3- to 6-membered heterocyclyl is alternative, which is a radical of 3- to 6-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms; 4- to 6-membered heterocyclyl is alternative, which is a radical of 4- to 6-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms; 5- to 6-membered heterocyclyl is more alternative, which is a radical of 5- to 6-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms; 5-membered heterocyclyl is more alternative, which is a radical of 5-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms; 6-membered heterocyclyl is more alternative, which is a radical of 6-membered non-aromatic ring system having ring carbon atoms and 1 to 3 ring heteroatoms. The heterocyclyl also includes a ring system wherein the heterocyclyl described above is fused with one or more cycloalkyl groups, wherein the point of attachment is on the heterocyclyl ring, or the heterocyclyl described above is fused with one or more aryl or heteroaryl groups, wherein the point of attachment is on the heterocyclyl ring; and in such cases, the number of ring members continues to represent the number of ring members in the heterocyclyl ring system. The heterocyclyl further comprises the heterocyclyl described above, in which the substituents on any non-adjacent carbon or nitrogen atoms are connected to form a bridge ring, together forming a polycyclic heteroalkane sharing two or more carbon or nitrogen atoms. The heterocyclyl further comprises the heterocyclyl described above, in which the substituents on the same carbon atom are connected to form a ring, together forming a polycyclic heteroalkane sharing one carbon atom. Exemplary 3-membered heterocyclyl groups containing one heteroatom include, but are not limited to, aziridinyl, oxiranyl and thiorenyl. Exemplary 4-membered heterocyclyl groups containing one heteroatom include, but are not limited to, azetidinyl, oxetanyl and thietanyl. Exemplary 5-membered heterocyclyl groups containing one heteroatom include, but are not limited to, tetrahydrofuranyl, dihydrofuranyl, tetrahydrothiophenyl, dihydrothienyl, pyrrolidinyl, dihydropyrrolyl and pyrrolyl-2,5-dione. Exemplary 5-membered heterocyclyl groups containing two heteroatoms include, but are not limited to, pyrazolidyl, dioxolanyl, oxasulfuranyl, disulfuranyl, and oxazolidin-2-one. Exemplary 5-membered heterocyclyl groups containing three heteroatoms include, but are not limited to, triazolinyl, oxadiazolinyl, and thiadiazolinyl. Exemplary 6-membered heterocyclyl groups containing one heteroatom include, but are not limited to, piperidyl, tetrahydropyranyl, dihydropyridyl and thianyl. Exemplary 6-membered heterocyclyl groups containing two heteroatoms include, but are not limited to, piperazinyl, morpholinyl, dithianyl and dioxanyl. Exemplary 6-membered heterocyclyl groups containing three heteroatoms include, but are not limited to, triazinanyl. Exemplary 7-membered heterocyclyl groups containing one heteroatom include, but are not limited to, azepanyl, oxepanyl and thiepanyl. Exemplary 5-membered heterocyclyl groups fused with a C<com:Sub>6< / com:Sub> aryl (also referred as 5,6-bicyclic heterocyclyl herein) include, but are not limited to, indolinyl, isoindolinyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, benzoxazolinonyl, etc. Exemplary 6-membered heterocyclyl groups fused with a C<com:Sub>6< / com:Sub> aryl (also referred as 6,6-bicyclic heterocyclyl herein) include, but are not limited to, tetrahydroquinolinyl, tetrahydroisoquinolinyl, etc. The heterocyclyl further includes the heterocyclyl described above sharing one or two atoms with a cycloalkyl, heterocyclyl, aryl or heteroaryl to form a bridged or spiro ring, as long as the valence permits, where the shared atom may be carbon or nitrogen atoms. The heterocyclyl further includes the heterocyclyl described above, which optionally can be substituted with one or more substituents, e.g., with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0065] "C<com:Sub>6-10< / com:Sub> aryl" refers to a radical of monocyclic or polycyclic (e.g., bicyclic) 4n+2 aromatic ring system having 6-10 ring carbon atoms and zero heteroatoms (e.g., having 6 or 10 shared <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math> electrons in a cyclic array). In some embodiments, the aryl group has six ring carbon atoms ("C<com:Sub>6< / com:Sub> aryl"; for example, phenyl). In some embodiments, the aryl group has ten ring carbon atoms ("<com:Math><semantics>C10<annotation encoding="application / x-tex">C_{10}< / annotation>< / semantics>< / com:Math> aryl"; for example, naphthyl, e.g., 1-naphthyl and 2-naphthyl). The aryl group also includes a ring system in which the aryl ring described above is fused with one or more cycloalkyl or heterocyclyl groups, and the point of attachment is on the aryl ring, in which case the number of carbon atoms continues to represent the number of carbon atoms in the aryl ring system. The aryl can be substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0066] "5- to 14-membered heteroaryl" refers to a radical of 5- to 14-membered monocyclic or bicyclic 4n+2 aromatic ring system (e.g., having 6, 10 or 14 shared <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math> electrons in a cyclic array) having ring carbon atoms and 1-4 ring heteroatoms, wherein each heteroatom is independently selected from nitrogen, oxygen and sulfur. In the heteroaryl group containing one or more nitrogen atoms, the point of attachment can be a carbon or nitrogen atom as long as the valence permits. heteroaryl bicyclic systems may include one or more heteroatoms in one or two rings. heteroaryl also includes ring systems wherein the heteroaryl ring described above is fused with one or more cycloalkyl or heterocyclyl groups, and the point of attachment is on the heteroaryl ring. In such case, the number the carbon atoms continues to represent the number of carbon atoms in the heteroaryl ring system. In some embodiments, 5- to 10-membered heteroaryl groups are alternative, which are radicals of 5- to 10-membered monocyclic or bicyclic 4n+2 aromatic ring systems having ring carbon atoms and 1-4 ring heteroatoms. In other embodiments, 5- to 6-membered heteroaryl groups are yet alternative, which are radicals of 5- to 6-membered monocyclic or bicyclic 4n+2 aromatic ring systems having ring carbon atoms and 1-4 ring heteroatoms. Exemplary 5-membered heteroaryl groups containing one heteroatom include, but are not limited to, pyrrolyl, furyl and thienyl. Exemplary 5-membered heteroaryl groups containing two heteroatoms include, but are not limited to, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, and isothiazolyl. Exemplary 5-membered heteroaryl groups containing three heteroatoms include, but are not limited to, triazolyl, oxadiazolyl (such as, 1,2,4-oxadiazolyl), and thiadiazolyl. Exemplary 5-membered heteroaryl groups containing four heteroatoms include, but are not limited to, tetrazolyl. Exemplary 6-membered heteroaryl groups containing one heteroatom include, but are not limited to, pyridyl or pyridonyl. Exemplary 6-membered heteroaryl groups containing two heteroatoms include, but are not limited to, pyridazinyl, pyrimidinyl, and pyrazinyl. Exemplary 6-membered heteroaryl groups containing three or four heteroatoms include, but are not limited to, triazinyl and tetrazinyl, respectively. Exemplary 7-membered heteroaryl groups containing one heteroatom include, but are not limited to, azepinyl, oxepinyl, and thiepinyl. Exemplary 5,6-bicyclic heteroaryl groups include, but are not limited to, indolyl, isoindolyl, indazolyl, benzotriazolyl, benzothiophenyl, isobenzothiophenyl, benzofuranyl, benzoisofuranyl, benzimidazolyl, benzoxazolyl, benzoisoxazolyl, benzoxadiazolyl, benzothiazolyl, benzoisothiazolyl, benzothiadiazolyl, indolizinyl and purinyl. Exemplary 6,6-bicyclic heteroaryl groups include, but are not limited to, naphthyridinyl, pteridinyl, quinolyl, isoquinolyl, cinnolinyl, quinoxalinyl, phthalazinyl and quinazolinyl. The heteroaryl can be substituted with one or more substituents, for example, with 1 to 5 substituents, 1 to 3 substituents or 1 substituent.

[0067] "Hydroxyalkyl" refers to an alkyl group that is substituted with one or more hydroxyl groups.

[0068] "Alkoxy" refers to an oxyether form of a linear or branched-chain alkyl group, i.e., an -O-alkyl group. Similarly, "methoxy" refers to -O-CH<com:Sub>3< / com:Sub>.

[0069] "Optionally substituted with" means that it can be substituted with the specified substituents or unsubstituted.

[0070] The divalent groups formed by removing another hydrogen from the groups defined above such as alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are collectively referred to as "-ylene". Ring-forming groups such as cycloalkyl, heterocyclyl, aryl and heteroaryl are collectively referred to as "cyclic groups".

[0071] alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl as defined herein are optionally substituted groups.

[0072] Exemplary substituents on carbon atoms include, but are not limited to, halogen, -CN, -NO<com:Sub>2< / com:Sub>, -N<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>H, -SO<com:Sub>3< / com:Sub>H, -OH, -OR aa, -ON(Rbb)<com:Sub>2< / com:Sub>, -N(Rbb)<com:Sub>2< / com:Sub>, -N(Rbb)<com:Sub>3< / com:Sub>+X-, -N(ORcc)Rbb, -SH, -SR<com:Sup>aa< / com:Sup>, -SSR<com:Sup>cc< / com:Sup>, -C(=O)R<com:Sup>aa< / com:Sup>, -CO<com:Sub>2< / com:Sub>H, -CHO, -C(OR<com:Sup>cc< / com:Sup>)<com:Sub>2< / com:Sub>, -CO<com:Sub>2< / com:Sub>R<com:Sup>aa< / com:Sup>, -OC(=O)R<com:Sup>aa< / com:Sup>, -OCO<com:Sub>2< / com:Sub>R<com:Sup>aa< / com:Sup>, <com:Math><semantics>−C(=O)N(Rbb)2<annotation encoding="application / x-tex">-C(=O)N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=O)N(Rbb)2<annotation encoding="application / x-tex">-OC(=O)N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbC(=O)Raa<annotation encoding="application / x-tex">-NR^{bb}C(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbCO2Raa<annotation encoding="application / x-tex">-NR^{bb}CO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbC(=O)N(Rbb)2<annotation encoding="application / x-tex">-NR^{bb}C(=O)N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRbb)Raa<annotation encoding="application / x-tex">-C(=NR^{bb})R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRbb)ORaa<annotation encoding="application / x-tex">-C(=NR^{bb})OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRbb)Raa<annotation encoding="application / x-tex">-OC(=NR^{bb})R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRbb)ORaa<annotation encoding="application / x-tex">-OC(=NR^{bb})OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRbb)N(Rbb)2<annotation encoding="application / x-tex">-C(=NR^{bb})N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRbb)N(Rbb)2<annotation encoding="application / x-tex">-OC(=NR^{bb})N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbC(=NRbb)N(Rbb)2<annotation encoding="application / x-tex">-NR^{bb}C(=NR^{bb})N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)NRbbSO2Raa<annotation encoding="application / x-tex">-C(=O)NR^{bb}SO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbSO2Raa<annotation encoding="application / x-tex">-NR^{bb}SO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(Rbb)2<annotation encoding="application / x-tex">-SO_2N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2Raa<annotation encoding="application / x-tex">-SO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2ORaa<annotation encoding="application / x-tex">-SO_2OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2Raa<annotation encoding="application / x-tex">-OSO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(=O)Raa<annotation encoding="application / x-tex">-S(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OS(=O)Raa<annotation encoding="application / x-tex">-OS(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Si(Raa)3<annotation encoding="application / x-tex">-Si(R^{aa})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSi(Raa)3<annotation encoding="application / x-tex">-OSi(R^{aa})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)N(Rbb)2<annotation encoding="application / x-tex">-C(=S)N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)SRaa,−C(=S)SRaa,−SC(=S)SRaa,−SC(=O)SRaa,−OC(=O)SRaa,−SC(=O)ORaa,<annotation encoding="application / x-tex">-C(=O)SR^{aa}, \quad -C(=S)SR^{aa}, \quad -SC(=S)SR^{aa}, \quad -SC(=O)SR^{aa}, \quad -OC(=O)SR^{aa}, \quad -SC(=O)OR^{aa},< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−SC(=O)Raa<annotation encoding="application / x-tex">-SC(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2Raa<annotation encoding="application / x-tex">-P(=O)_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)2Raa<annotation encoding="application / x-tex">-OP(=O)_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(Raa)2<annotation encoding="application / x-tex">-P(=O)(R^{aa})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(Raa)2<annotation encoding="application / x-tex">-OP(=O)(R^{aa})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(ORcc)2<annotation encoding="application / x-tex">-OP(=O)(OR^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2N(Rbb)2<annotation encoding="application / x-tex">-P(=O)_2N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)2N(Rbb)2<annotation encoding="application / x-tex">-OP(=O)_2N(R^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(NRbb)2<annotation encoding="application / x-tex">-P(=O)(NR^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(NRbb)2<annotation encoding="application / x-tex">-OP(=O)(NR^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbP(=O)(ORcc)2<annotation encoding="application / x-tex">-NR^{bb}P(=O)(OR^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbbP(=O)(NRbb)2<annotation encoding="application / x-tex">-NR^{bb}P(=O)(NR^{bb})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(Rcc)2<annotation encoding="application / x-tex">-P(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(Rcc)3<annotation encoding="application / x-tex">-P(R^{cc})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(Rcc)2<annotation encoding="application / x-tex">-OP(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(Rcc)3<annotation encoding="application / x-tex">-OP(R^{cc})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−B(Raa)2<annotation encoding="application / x-tex">-B(R^{aa})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−B(ORcc)2<annotation encoding="application / x-tex">-B(OR^{cc})_2< / annotation>< / semantics>< / com:Math>, -BR<com:Sup>aa< / com:Sup>(OR<com:Sup>cc< / com:Sup>), alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>dd< / com:Sup> groups;

[0073] or two geminal hydrogen on a carbon atom are replaced with =O, =S, =NN(R<com:Sup>bb< / com:Sup>)<com:Sub>2< / com:Sub>, <com:Math><semantics>=NNRbbC(=O)Raa<annotation encoding="application / x-tex">=NNR^{bb}C(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>=NNRbbC(=O)ORaa<annotation encoding="application / x-tex">=NNR^{bb}C(=O)OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>=NNRbbS(=O)2Raa<annotation encoding="application / x-tex">=NNR^{bb}S(=O)_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>=NRbb<annotation encoding="application / x-tex">=NR^{bb}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>=NORcc<annotation encoding="application / x-tex">=NOR^{cc}< / annotation>< / semantics>< / com:Math> groups;

[0074] each of the R<com:Sup>aa< / com:Sup> is independently selected from alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, or two of the R<com:Sup>aa< / com:Sup> groups are combined to form a heterocyclyl or heteroaryl ring, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>dd< / com:Sup> groups;

[0075] each of the R<com:Sup>bb< / com:Sup> is independently selected from hydrogen, -OH, -OR<com:Sup>aa< / com:Sup>, -N(R<com:Sup>cc< / com:Sup>)<com:Sub>2< / com:Sub>, -CN, <com:Math><semantics>−C(=O)Raa<annotation encoding="application / x-tex">-C(=O)R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)N(Rcc)2<annotation encoding="application / x-tex">-C(=O)N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CO2Raa<annotation encoding="application / x-tex">-CO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2Raa<annotation encoding="application / x-tex">-SO_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRcc)ORaa<annotation encoding="application / x-tex">-C(=NR^{cc})OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRcc)N(Rcc)2<annotation encoding="application / x-tex">-C(=NR^{cc})N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(Rcc)2<annotation encoding="application / x-tex">-SO_2N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2Rcc<annotation encoding="application / x-tex">-SO_2R^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2ORcc<annotation encoding="application / x-tex">-SO_2OR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SORaa<annotation encoding="application / x-tex">-SOR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)N(Rcc)2<annotation encoding="application / x-tex">-C(=S)N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)SRcc<annotation encoding="application / x-tex">-C(=O)SR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)SRcc<annotation encoding="application / x-tex">-C(=S)SR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2Raa<annotation encoding="application / x-tex">-P(=O)_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(Raa)2<annotation encoding="application / x-tex">-P(=O)(R^{aa})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2N(Rcc)2<annotation encoding="application / x-tex">-P(=O)_2N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(NRcc)2<annotation encoding="application / x-tex">-P(=O)(NR^{cc})_2< / annotation>< / semantics>< / com:Math>, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, or two R<com:Sup>bb< / com:Sup> groups are combined to form a heterocyclyl or a heteroaryl ring, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>dd< / com:Sup> groups;

[0076] each of the R<com:Sup>cc< / com:Sup> is independently selected from hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, or two R<com:Sup>cc< / com:Sup> groups are combined to form a heterocyclyl or a heteroaryl ring, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>dd< / com:Sup> groups;

[0077] each of the R<com:Sup>dd< / com:Sup> is independently selected from halogen, -CN, -NO<com:Sub>2< / com:Sub>, -N<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>H, <com:Math><semantics>−SO3H<annotation encoding="application / x-tex">-SO_3H< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OH<annotation encoding="application / x-tex">-OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−ORee<annotation encoding="application / x-tex">-OR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−ON(Rff)2<annotation encoding="application / x-tex">-ON(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(Rff)2<annotation encoding="application / x-tex">-N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(Rff)3+X−<annotation encoding="application / x-tex">-N(R^{ff})_3^+X^-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(ORee)Rff<annotation encoding="application / x-tex">-N(OR^{ee})R^{ff}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SH<annotation encoding="application / x-tex">-SH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SRee<annotation encoding="application / x-tex">-SR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SSRee<annotation encoding="application / x-tex">-SSR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)Ree<annotation encoding="application / x-tex">-C(=O)R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CO2H<annotation encoding="application / x-tex">-CO_2H< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CO2Ree<annotation encoding="application / x-tex">-CO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=O)Ree<annotation encoding="application / x-tex">-OC(=O)R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OCO2Ree<annotation encoding="application / x-tex">-OCO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)N(Rff)2<annotation encoding="application / x-tex">-C(=O)N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=O)N(Rff)2<annotation encoding="application / x-tex">-OC(=O)N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRffC(=O)Ree<annotation encoding="application / x-tex">-NR^{ff}C(=O)R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRffCO2Ree<annotation encoding="application / x-tex">-NR^{ff}CO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRffC(=O)N(Rff)2<annotation encoding="application / x-tex">-NR^{ff}C(=O)N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRff)ORee<annotation encoding="application / x-tex">-C(=NR^{ff})OR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRff)Ree<annotation encoding="application / x-tex">-OC(=NR^{ff})R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRff)ORee<annotation encoding="application / x-tex">-OC(=NR^{ff})OR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRff)N(Rff)2<annotation encoding="application / x-tex">-C(=NR^{ff})N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NRff)N(Rff)2<annotation encoding="application / x-tex">-OC(=NR^{ff})N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRffC(=NRff)N(Rff)2<annotation encoding="application / x-tex">-NR^{ff}C(=NR^{ff})N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRffSO2Ree<annotation encoding="application / x-tex">-NR^{ff}SO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(Rff)2<annotation encoding="application / x-tex">-SO_2N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2Ree<annotation encoding="application / x-tex">-SO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2ORee<annotation encoding="application / x-tex">-SO_2OR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2Ree<annotation encoding="application / x-tex">-OSO_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(=O)Ree<annotation encoding="application / x-tex">-S(=O)R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Si(Ree)3<annotation encoding="application / x-tex">-Si(R^{ee})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSi(Ree)3<annotation encoding="application / x-tex">-OSi(R^{ee})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)N(Rff)2<annotation encoding="application / x-tex">-C(=S)N(R^{ff})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)SRee<annotation encoding="application / x-tex">-C(=O)SR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)SRee<annotation encoding="application / x-tex">-C(=S)SR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(=S)SRee<annotation encoding="application / x-tex">-SC(=S)SR^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2Ree<annotation encoding="application / x-tex">-P(=O)_2R^{ee}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(Ree)2<annotation encoding="application / x-tex">-P(=O)(R^{ee})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(Ree)2<annotation encoding="application / x-tex">-OP(=O)(R^{ee})_2< / annotation>< / semantics>< / com:Math>, -OP(=O)(OR<com:Sup>ee< / com:Sup>)<com:Sub>2< / com:Sub>, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>gg< / com:Sup> groups, or two geminal R<com:Sup>dd< / com:Sup> substituents can be combined to form=O or =S;

[0078] each of the R<com:Sup>ee< / com:Sup> is independently selected from alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>gg< / com:Sup> groups;

[0079] each of the R<com:Sup>ff< / com:Sup> is independently selected from hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, or two R<com:Sup>ff< / com:Sup> groups are combined to form a heterocyclyl or a heteroaryl ring, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 Rgg groups;

[0080] each of the R<com:Sup>gg< / com:Sup> is independently selected from halogen, -CN, -NO<com:Sub>2< / com:Sub>, -N<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>H, <com:Math><semantics>−SO3H<annotation encoding="application / x-tex">-SO_3H< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OH<annotation encoding="application / x-tex">-OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC1−6<annotation encoding="application / x-tex">-OC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−ON(C1−6<annotation encoding="application / x-tex">-ON(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−N(C1−6<annotation encoding="application / x-tex">-N(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−N(C1−6<annotation encoding="application / x-tex">-N(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>3< / com:Sub><com:Math><semantics>+X−<annotation encoding="application / x-tex">^+X^-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH(C1−6<annotation encoding="application / x-tex">-NH(C_{1-6}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>alkyl)2+X−<annotation encoding="application / x-tex">alkyl)_2^+X^-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH2(C1−6alkyl)+X−<annotation encoding="application / x-tex">-NH_2(C_{1-6} alkyl)^+X^-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NH3+X−<annotation encoding="application / x-tex">-NH_3^+X^-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(OC1−6alkyl)(C1−6alkyl)<annotation encoding="application / x-tex">-N(OC_{1-6} alkyl)(C_{1-6} alkyl)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(OH)(C1−6alkyl)<annotation encoding="application / x-tex">-N(OH)(C_{1-6} alkyl)< / annotation>< / semantics>< / com:Math>, -NH(OH), -SH, -SC<com:Sub>1-6< / com:Sub> alkyl, -SS(C<com:Sub>1-6< / com:Sub> alkyl), -C(=O)(C<com:Sub>1-6< / com:Sub> alkyl), -CO<com:Sub>2< / com:Sub>H, -CO<com:Sub>2< / com:Sub>(C<com:Sub>1-6< / com:Sub> alkyl), <com:Math><semantics>−OC(=O)(C1−6 alkyl),−OCO2(C1−6 alkyl),−C(=O)NH2,−C(=O)N(C1−6 alkyl)2,−OC(=O)NH(C1−6 alkyl)2<annotation encoding="application / x-tex">-OC(=O)(C_{1-6} \text{ alkyl}), -OCO_2(C_{1-6} \text{ alkyl}), -C(=O)NH_2, -C(=O)N(C_{1-6} \text{ alkyl})_2, -OC(=O)NH(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>−NHC(=O)(C1−6 alkyl)<annotation encoding="application / x-tex">-NHC(=O)(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−N(C1−6 alkyl)C(=O)(C1−6 alkyl)<annotation encoding="application / x-tex">-N(C_{1-6} \text{ alkyl})C(=O)(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHCO2(C1−6 alkyl)<annotation encoding="application / x-tex">-NHCO_2(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHC(=O)N(C1−6 alkyl)2<annotation encoding="application / x-tex">-NHC(=O)N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHC(=O)NH(C1−6 alkyl)<annotation encoding="application / x-tex">-NHC(=O)NH(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHC(=O)NH2<annotation encoding="application / x-tex">-NHC(=O)NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NH)O(C1−6 alkyl)<annotation encoding="application / x-tex">-C(=NH)O(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NH)(C1−6 alkyl),−OC(=NH)OC1−6 alkyl,−C(=NH)N(C1−6 alkyl)2,−C(=NH)NH(C1−6 alkyl)2<annotation encoding="application / x-tex">-OC(=NH)(C_{1-6} \text{ alkyl}), -OC(=NH)OC_{1-6} \text{ alkyl}, -C(=NH)N(C_{1-6} \text{ alkyl})_2, -C(=NH)NH(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>−C(=NH)NH2<annotation encoding="application / x-tex">-C(=NH)NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(=NH)N(C1−6 alkyl)2<annotation encoding="application / x-tex">-OC(=NH)N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(NH)NH(C1−6 alkyl)<annotation encoding="application / x-tex">-OC(NH)NH(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(NH)NH2<annotation encoding="application / x-tex">-OC(NH)NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHC(NH)N(C1−6 alkyl)2<annotation encoding="application / x-tex">-NHC(NH)N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHC(=NH)NH2<annotation encoding="application / x-tex">-NHC(=NH)NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NHSO2(C1−6 alkyl)<annotation encoding="application / x-tex">-NHSO_2(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(C1−6 alkyl)2<annotation encoding="application / x-tex">-SO_2N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH(C1−6 alkyl)<annotation encoding="application / x-tex">-SO_2NH(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2C1−6 alkyl<annotation encoding="application / x-tex">-SO_2C_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2OC1−6 alkyl<annotation encoding="application / x-tex">-SO_2OC_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2C1−6 alkyl<annotation encoding="application / x-tex">-OSO_2C_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOC1−6<annotation encoding="application / x-tex">-SOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−Si(C1−6 alkyl)3<annotation encoding="application / x-tex">-Si(C_{1-6} \text{ alkyl})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSi(C1−6 alkyl)3<annotation encoding="application / x-tex">-OSi(C_{1-6} \text{ alkyl})_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)N(C1−6 alkyl)2<annotation encoding="application / x-tex">-C(=S)N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)NH(C1−6 alkyl)<annotation encoding="application / x-tex">C(=S)NH(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C(=S)NH2<annotation encoding="application / x-tex">C(=S)NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)S(C1−6 alkyl)<annotation encoding="application / x-tex">-C(=O)S(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)SC1−6 alkyl<annotation encoding="application / x-tex">-C(=S)SC_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(=S)SC1−6 alkyl<annotation encoding="application / x-tex">-SC(=S)SC_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2(C1−6 alkyl)<annotation encoding="application / x-tex">-P(=O)_2(C_{1-6} \text{ alkyl})< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(C1−6 alkyl)2<annotation encoding="application / x-tex">-P(=O)(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(C1−6 alkyl)2<annotation encoding="application / x-tex">-OP(=O)(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OP(=O)(OC1−6 alkyl)2<annotation encoding="application / x-tex">-OP(=O)(OC_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−6 alkyl<annotation encoding="application / x-tex">C_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−6 haloalkyl<annotation encoding="application / x-tex">C_{1-6} \text{ haloalkyl}< / annotation>< / semantics>< / com:Math>, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkenyl, C<com:Sub>2< / com:Sub>-C<com:Sub>6< / com:Sub> alkynyl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> cycloalkyl, C<com:Sub>6< / com:Sub>-C<com:Sub>10< / com:Sub> aryl, C<com:Sub>3< / com:Sub>-C<com:Sub>7< / com:Sub> heterocyclyl, C<com:Sub>5< / com:Sub>-C<com:Sub>10< / com:Sub> heteroaryl; or two geminal R<com:Sup>gg< / com:Sup> substituents may combine to form =O or =S; wherein X<com:Sup>-< / com:Sup> is a counter-ion.

[0081] Exemplary substituents on nitrogen atoms include, but are not limited to, hydrogen, -OH, -OR<com:Sup>aa< / com:Sup>, -N(R<com:Sup>cc< / com:Sup>)<com:Sub>2< / com:Sub>, -CN, -C(=O)R<com:Sup>aa< / com:Sup>, -C(=O)N(R<com:Sup>cc< / com:Sup>)<com:Sub>2< / com:Sub>, -CO<com:Sub>2< / com:Sub>R<com:Sup>aa< / com:Sup>, -SO<com:Sub>2< / com:Sub>R<com:Sup>aa< / com:Sup>, -C(=NR<com:Sup>bb< / com:Sup>)R<com:Sup>aa< / com:Sup>, <com:Math><semantics>−C(=NRcc)ORaa<annotation encoding="application / x-tex">-C(=NR^{cc})OR^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=NRcc)N(Rcc)2<annotation encoding="application / x-tex">-C(=NR^{cc})N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(Rcc)2<annotation encoding="application / x-tex">-SO_2N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2Rcc<annotation encoding="application / x-tex">-SO_2R^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2ORcc<annotation encoding="application / x-tex">-SO_2OR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SORaa<annotation encoding="application / x-tex">-SO_R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)N(Rcc)2<annotation encoding="application / x-tex">-C(=S)N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=O)SRcc<annotation encoding="application / x-tex">-C(=O)SR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(=S)SRcc<annotation encoding="application / x-tex">-C(=S)SR^{cc}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2Raa<annotation encoding="application / x-tex">-P(=O)_2R^{aa}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(Raa)2<annotation encoding="application / x-tex">-P(=O)(R^{aa})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)2N(Rcc)2<annotation encoding="application / x-tex">-P(=O)_2N(R^{cc})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−P(=O)(NRcc)2<annotation encoding="application / x-tex">-P(=O)(NR^{cc})_2< / annotation>< / semantics>< / com:Math>, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, or two R<com:Sup>cc< / com:Sup> groups attached to a nitrogen atom combine to form a heterocyclyl or a heteroaryl ring, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently substituted with 0, 1, 2, 3, 4 or 5 R<com:Sup>dd< / com:Sup> groups, and wherein R<com:Sup>aa< / com:Sup>, R<com:Sup>bb< / com:Sup>, R<com:Sup>cc< / com:Sup> and R<com:Sup>dd< / com:Sup> are as described herein.

[0082] "Nucleic acids" refers to single- or double-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules and their heterozygous molecules. Examples of nucleic acid molecules include, but are not limited to, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), self-amplified RNA (saRNA), and antisense oligonucleotides (ASO), etc. Nucleic acids may be further chemically modified, and the chemical modifier selected from one of, or a combination of: pseudouridine, N1-methyl-pseudouridine, 5-methoxyuridine, and 5-methylcytosine. mRNA molecules contain protein coding regions and may further contain expression regulatory sequences. Typical expression regulatory sequences include, but are not limited to, 5' cap, 5' untranslated region (5' UTR), 3' untranslated region (3' UTR), polyadenylate sequence (PolyA), miRNA binding sites.

[0083] "Cationic lipids" refers to lipid molecules that is capable of being positively charged at physiological pH conditions. In some embodiments, the cationic lipid is an amino lipid.

[0084] "Neutral lipids" refers to lipid molecules that is not charged at a particular pH, such as physiological pH conditions. Examples of neutral lipids include, but are not limited to 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE).

[0085] "Structure lipids" refers to lipids that enhance the stability of nanoparticles by filling the gaps between lipids, commonly such as steroids. The steroid is a compound having a perhydrocyclopentanophenanthrene carbon framework. In an alternative embodiment, the steroid is cholesterol, sitosterol, coprosterol, fucosterol, brassicasterol, ergosterol, tomatine, ursolic acid, <com:Math><semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>< / com:Math>-tocopherol, stigmasterol, avenasterol, ergocalciferol or campesterol.

[0086] "Polymer lipids" refers to molecules containing a polymer moiety and a lipid moiety. In some embodiments, the polymer lipid is a polyethylene glycol (PEG) lipid. Other lipids that can reduce aggregation, such as products of compounds having uncharged, hydrophilic, space-barrier moieties coupled with lipid may also be used.

[0087] "Lipid nanoparticles" refers to particles containing lipid components of nanoscale size.

[0088] "Biodegradable groups" refers to functional groups that contain biodegradable bonds, such as esters, disulfide bonds and amides, etc. Biodegradation may affect the process of removing compounds from the body. The biodegradable groups of the present disclosure are oriented from the head to the tail in ionizable lipid molecules. Other terminology

[0089] The term "treating" as used herein relates to reversing, alleviating or inhibiting the progression or prevention of the disorders or conditions to which the term applies, or of one or more symptoms of such disorders or conditions. The noun "treatment" as used herein relates to the action of treating, which is a verb, and the latter is as just defined.

[0090] The term "pharmaceutically acceptable salt" as used herein refers to those carboxylate and amino acid addition salts of the compounds of the present disclosure, which are suitable for the contact with patients' tissues within a reliable medical judgment, and do not produce inappropriate toxicity, irritation, allergy, etc. They are commensurate with a reasonable benefit / risk ratio, and are effective for their intended use. The term includes, if possible, the zwitterionic form of the compounds of the disclosure.

[0091] The pharmaceutically acceptable base addition salts are formed with metals or amines, such as alkali metal and alkaline earth metal hydroxides or organic amines. Examples of the metals used as cations include sodium, potassium, magnesium, calcium, etc. Examples of suitable amines are N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, N-methylglucamine and procaine.

[0092] The base addition salt of the acidic compound can be prepared by contacting the free acid form with a sufficient amount of the required base to form a salt in a conventional manner. The free acid can be regenerated by contacting the salt form with an acid in a conventional manner and then isolating the free acid. The free acid forms are somewhat different from their respective salt forms in their physical properties, such as solubility in polar solvents. But for the purposes of the present disclosure, the salts are still equivalent to their respective free acids.

[0093] The salts can be prepared from the inorganic acids, which include sulfates, pyrosulfates, bisulfates, sulfites, bisulfites, nitrates, phosphates, monohydrogen phosphates, dihydrogen phosphates, metaphosphates, pyrophosphates, chlorides, bromides and iodides. Examples of the acids include hydrochloric acid, nitric acid, sulfuric acid, hydrobromic acid, hydroiodic acid, phosphoric acid, etc. The representative salts include hydrobromide, hydrochloride, sulfate, bisulfate, nitrate, acetate, oxalate, valerate, oleate, palmitate, stearate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, naphthalate, methanesulfonate, glucoheptanate, lactobionate, lauryl sulfonate, isethionate, etc. The salts can also be prepared from the organic acids, which include aliphatic monocarboxylic and dicarboxylic acids, phenyl-substituted alkanoic acids, hydroxyalkanoic acids, alkanedioic acid, aromatic acids, aliphatic and aromatic sulfonic acids, etc. The representative salts include acetate, propionate, octanoate, isobutyrate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, mandelate, benzoate, chlorobenzoate, methyl benzoate, dinitrobenzoate, naphthoate, besylate, tosylate, phenylacetate, citrate, lactate, maleate, tartrate, methanesulfonate, etc. The pharmaceutically acceptable salts can include cations based on alkali metals and alkaline earth metals, such as sodium, lithium, potassium, calcium, magnesium, etc., as well as non-toxic ammonium, quaternary ammonium, and amine cations including, but not limited to, ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine, etc. Salts of amino acids are also included, such as arginine salts, gluconates, galacturonates, etc. (for example, see Berge S. M. et al., "Pharmaceutical Salts," J. Pharm. Sci., 1977; 66: 1-19 for reference).

[0094] "Subjects" to which administration is contemplated include, but are not limited to, humans (e.g., males or females of any age group, e.g., paediatric subjects (e.g., infants, children, adolescents) or adult subjects (e.g., young adults, middle-aged adults or older adults) and / or non-human animals, such as mammals, e.g., primates (e.g., cynomolgus monkeys, rhesus monkeys), cattle, pigs, horses, sheep, goats, rodents, cats and / or dogs. In some embodiments, the subject is a human. In some embodiments, the subject is a non-human animal. The terms "human", "patient" and "subject" can be used interchangeably herein.

[0095] "Disease", "disorder", and "condition" can be used interchangeably herein.

[0096] Unless otherwise indicated, the term "treatment" as used herein includes the effect on a subject who is suffering from a particular disease, disorder, or condition, which reduces the severity of the disease, disorder, or condition, or delays or slows the progression of the disease, disorder or condition ("therapeutic treatment"). The term also includes the effect that occurs before the subject begins to suffer from a specific disease, disorder or condition ("prophylactic treatment").

[0097] Generally, the "effective amount" of a pharmaceutical composition refers to an amount sufficient to elicit a target biological response. As understood by those skilled in the art, the effective amount of the pharmaceutical composition of the disclosure can vary depending on the following factors, such as the desired biological endpoint, the pharmacokinetics of the pharmaceutical composition, the diseases being treated, the mode of administration, and the age, health status and symptoms of the subjects. The effective amount includes therapeutically effective amount and prophylactically effective amount.

[0098] Unless otherwise indicated, the "therapeutically effective amount" of the pharmaceutical composition as used herein is an amount sufficient to provide therapeutic benefits in the course of treating a disease, disorder or condition, or to delay or minimize one or more symptoms associated with the disease, disorder or condition. The therapeutically effective amount of a pharmaceutical composition refers to the amount of the therapeutic agent that, when used alone or in combination with other therapies, provides a therapeutic benefit in the treatment of a disease, disorder or condition. The term "therapeutically effective amount" can include an amount that improves the overall treatment, reduces or avoids the symptoms or causes of the disease or condition, or enhances the therapeutic effect of other therapeutic agents.

[0099] Unless otherwise indicated, the "prophylactically effective amount" of the pharmaceutical composition as used herein is an amount sufficient to prevent a disease, disorder or condition, or an amount sufficient to prevent one or more symptoms associated with a disease, disorder or condition, or an amount sufficient to prevent the recurrence of a disease, disorder or condition. The prophylactically effective amount of a pharmaceutical composition refers to the amount of a therapeutic agent that, when used alone or in combination with other agents, provides a prophylactic benefit in the prevention of a disease, disorder or condition. The term "prophylactically effective amount" can include an amount that improves the overall prevention, or an amount that enhances the prophylactic effect of other preventive agents.

[00100] "Combination" and related terms refer to the simultaneous or sequential administration of the pharmaceutical compositions of the present disclosure and other therapeutic agents. For example, the pharmaceutical compositions of the present disclosure can be administered simultaneously or sequentially in separate unit dosage with other therapeutic agents, or simultaneously in a single unit dosage with other therapeutic agents. DETAILED DESCRIPTION OF THE INVENTION

[00101] As used herein, "compounds of the present disclosure" refers to the following compounds of formula (IV), formula (VI), formula (VII), and the like, pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof.

[00102] In the present disclosure, compounds are named using standard nomenclature. For compounds having an asymmetric center, it should be understood, unless otherwise stated, that all optical isomers and mixtures thereof are included. Furthermore, unless otherwise specified, all isomer compounds and carbon-carbon double bonds included in the present disclosure may occur in the form of Z and E. Compounds which exist in different tautomeric forms, one of which is not limited to any particular tautomer, but is intended to cover all tautomeric forms.

[00103] In one embodiment, the present disclosure relates to a compound of formula (IV), or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document]

[00104] wherein,

[00105] M<com:Sub>1< / com:Sub> and M<com:Sub>2< / com:Sub> are independently selected from -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>a< / com:Sub>-, <com:Math><semantics>−NRaC(O)NRa<annotation encoding="application / x-tex">-NR_aC(O)NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)S<annotation encoding="application / x-tex">-OC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRaC(O)O<annotation encoding="application / x-tex">-NR_aC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRa<annotation encoding="application / x-tex">-NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRa<annotation encoding="application / x-tex">-C(O)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)<annotation encoding="application / x-tex">-NR_{a}C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)S<annotation encoding="application / x-tex">-NR_{a}C(O)S< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)NRa<annotation encoding="application / x-tex">-SC(O)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(S)NRa<annotation encoding="application / x-tex">-OC(S)NR_{a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(S)O−<annotation encoding="application / x-tex">-NR_aC(S)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−S−<annotation encoding="application / x-tex">-S_{-}S_{-}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−S(O)0−2<annotation encoding="application / x-tex">-S(O)_{0-2}< / annotation>< / semantics>< / com:Math>-;

[00106] Q is selected from a chemical bond, -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>b< / com:Sub>-, <com:Math><semantics>−NRbC(O)NRb−<annotation encoding="application / x-tex">-NR_bC(O)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)S−<annotation encoding="application / x-tex">-OC(O)S_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)O−<annotation encoding="application / x-tex">-OC(O)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(O)O−<annotation encoding="application / x-tex">-NR_bC(O)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)−<annotation encoding="application / x-tex">-OC(O)_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)−<annotation encoding="application / x-tex">-SC(O)_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)S−<annotation encoding="application / x-tex">-C(O)S_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRb−<annotation encoding="application / x-tex">-NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)NRb<annotation encoding="application / x-tex">-C(O)NR_{b}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)<annotation encoding="application / x-tex">-NR_{b}C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)S<annotation encoding="application / x-tex">-NR_{b}C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)NRb<annotation encoding="application / x-tex">-SC(O)NR_{b}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)NRb<annotation encoding="application / x-tex">-OC(S)NR_{b}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(S)O−<annotation encoding="application / x-tex">-NR_bC(S)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−S−<annotation encoding="application / x-tex">-S_{-}S_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)0−2−<annotation encoding="application / x-tex">-S(O)_{0-2-}< / annotation>< / semantics>< / com:Math>, phenylene and pyridylidene, wherein, the phenylene or pyridylidene is optionally substituted with one or more R*;

[00107] <com:Math><semantics>G5<annotation encoding="application / x-tex">G_5< / annotation>< / semantics>< / com:Math> is a chemical bond or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with one or more R**;

[00108] G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> are independently a chemical bond or C<com:Sub>1-7< / com:Sub> alkylene, which is optionally substituted with one or more R**;

[00109] <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 0, 1, 2, 3, 4, 5, 6 or 7 carbon atoms;

[00110] R<com:Sub>9< / com:Sub>, R<com:Sub>10< / com:Sub> and R** are independently H, C<com:Sub>1-8< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>, -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>;

[00111] G<com:Sub>1< / com:Sub>, G<com:Sub>2< / com:Sub>, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> are independently a chemical bond, C<com:Sub>1-13< / com:Sub> alkylene, C<com:Sub>2-13< / com:Sub> alkenylene or <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene, which is optionally substituted with one or more <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>;

[00112] G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[00113] G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[00114] <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are independently H, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl, C<com:Sub>6-10< / com:Sub> aryl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*:

[00115] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 14-membered heterocyclyl, which is optionally substituted with one or more R*;

[00116] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*;

[00117] R* is independently H, halogen, cyano, C<com:Sub>1-10< / com:Sub> alkyl, C<com:Sub>1-10< / com:Sub> haloalkyl, -L<com:Sub>b< / com:Sub>-OR<com:Sub>b< / com:Sub>, -L<com:Sub>b< / com:Sub>-SR<com:Sub>b< / com:Sub> or <com:Math><semantics>−Lb<annotation encoding="application / x-tex">-L_b< / annotation>< / semantics>< / com:Math>-NR<com:Sub>b< / com:Sub>R'<com:Sub>b< / com:Sub>;

[00118] <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, which is optionally substituted with one or more R*;

[00119] <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl, which is optionally substituted with one or more R, and wherein one or more methylene units are optionally and independently replaced with -NR''-;

[00120] <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-OR<com:Sub>d< / com:Sub>, <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-SR<com:Sub>d< / com:Sub> or <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>;

[00121] R is independently H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>a< / com:Sub>-OR<com:Sub>a< / com:Sub>, -L<com:Sub>a< / com:Sub>-SR<com:Sub>a< / com:Sub> or -L<com:Sub>a< / com:Sub>-NR<com:Sub>a< / com:Sub>R'<com:Sub>a< / com:Sub>;

[00122] R" is independently H or <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl;

[00123] L<com:Sub>a< / com:Sub> and L<com:Sub>e< / com:Sub> are independently a chemical bond or C<com:Sub>1-20< / com:Sub> alkylene;

[00124] <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene;

[00125] L<com:Sub>c< / com:Sub> is independently a chemical bond or C<com:Sub>1-8< / com:Sub> alkylene;

[00126] L<com:Sub>d< / com:Sub> is independently a chemical bond or C<com:Sub>1-14< / com:Sub> alkylene;

[00127] R<com:Sub>a< / com:Sub> and R'<com:Sub>a< / com:Sub> are independently selected from H, C<com:Sub>1-20< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>e< / com:Sub>-OR<com:Sub>e< / com:Sub>, -L<com:Sub>e< / com:Sub>-SR<com:Sub>e< / com:Sub> and -L<com:Sub>e< / com:Sub>-NR<com:Sub>e< / com:Sub>R'<com:Sub>e< / com:Sub>;

[00128] R<com:Sub>b< / com:Sub> and R'<com:Sub>b< / com:Sub> are independently selected from H, C<com:Sub>1-10< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>f< / com:Sub>-OR<com:Sub>f< / com:Sub>, -L<com:Sub>f< / com:Sub>-SR<com:Sub>f< / com:Sub> and -L<com:Sub>f< / com:Sub>-NR<com:Sub>f< / com:Sub>R'<com:Sub>f< / com:Sub>;

[00129] <com:Math><semantics>Rc<annotation encoding="application / x-tex">R_c< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rc′<annotation encoding="application / x-tex">R'_c< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>H<annotation encoding="application / x-tex">H< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl;

[00130] R<com:Sub>d< / com:Sub> and R'<com:Sub>d< / com:Sub> are independently H or C<com:Sub>1-14< / com:Sub> alkyl;

[00131] <com:Math><semantics>Re<annotation encoding="application / x-tex">R_e< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Re′<annotation encoding="application / x-tex">R'_e< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl;

[00132] <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rf′<annotation encoding="application / x-tex">R'_f< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl. <com:Math><semantics>

[00133] M1 and M2<annotation encoding="application / x-tex">

[00133] M_1 \text{ and } M_2< / annotation>< / semantics>< / com:Math>

[00134] In one embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -C(O)O-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -O-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -SC(O)O-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -OC(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -NR<com:Sub>a< / com:Sub>C(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -OC(O)S-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−NRaC(O)O<annotation encoding="application / x-tex">-NR_aC(O)O< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -C(O)S-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C(O)NRa<annotation encoding="application / x-tex">-C(O)NR_a< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−NRaC(O)<annotation encoding="application / x-tex">-NR_aC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -NR<com:Sub>a< / com:Sub>C(O)S-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -SC(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -C(O)-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -OC(S)-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -C(S)O-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−OC(S)NRa<annotation encoding="application / x-tex">-OC(S)NR_a< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−NRaC(S)O<annotation encoding="application / x-tex">-NR_aC(S)O< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -S-S-; in another embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is -S(O)<com:Sub>0-2< / com:Sub>-.

[00135] In one embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -C(O)O-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -O-; in another embodiment, M<com:Sub>2< / com:Sub> is -SC(O)O-; in another embodiment, M<com:Sub>2< / com:Sub> is -OC(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -NR<com:Sub>a< / com:Sub>C(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -OC(O)S-; in another embodiment, M2 is -OC(O)O-; in another embodiment, M2 is -NRaC(O)O-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, M<com:Sub>2< / com:Sub> is -C(O)S-; in another embodiment, M<com:Sub>2< / com:Sub> is -NR<com:Sub>a< / com:Sub>-; in another embodiment, M<com:Sub>2< / com:Sub> is <com:Math><semantics>−C(O)NRa<annotation encoding="application / x-tex">-C(O)NR_a< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−NRaC(O)<annotation encoding="application / x-tex">-NR_aC(O)< / annotation>< / semantics>< / com:Math>-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -NR<com:Sub>a< / com:Sub>C(O)S-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -SC(O)NR<com:Sub>a< / com:Sub>-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -C(O)-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -OC(S)-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -C(S)O-; in another embodiment, M<com:Sub>2< / com:Sub> is -OC(S)NR<com:Sub>a< / com:Sub>-; in another embodiment, M<com:Sub>2< / com:Sub> is -NR<com:Sub>a< / com:Sub>C(S)O-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -S-S-; in another embodiment, <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is -S(O)<com:Sub>0-2< / com:Sub>-.

[00136] In a more specific embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> are independently selected from -C(O)O-, <com:Math><semantics>−SC(O)O−<annotation encoding="application / x-tex">-SC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)NRa−<annotation encoding="application / x-tex">-OC(O)NR_a-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)NRa−<annotation encoding="application / x-tex">-NR_aC(O)NR_a-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)S−<annotation encoding="application / x-tex">-OC(O)S-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)O−<annotation encoding="application / x-tex">-OC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)O−<annotation encoding="application / x-tex">-NR_aC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)S−<annotation encoding="application / x-tex">-C(O)S-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)NRa<annotation encoding="application / x-tex">-C(O)NR_a< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)S<annotation encoding="application / x-tex">-NR_aC(O)S< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)NRa<annotation encoding="application / x-tex">-SC(O)NR_a< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(S)NRa<annotation encoding="application / x-tex">-OC(S)NR_a< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−NRaC(S)O<annotation encoding="application / x-tex">-NR_aC(S)O< / annotation>< / semantics>< / com:Math>; in another more specific embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> are independently -C(O)O-, -C(O)S-, -C(O)NR<com:Sub>a< / com:Sub>-, or -C(S)O-; in another more specific embodiment, <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> are independently -C(O)O-, <com:Math><semantics>−C(O)S−or−C(O)NRa−.<annotation encoding="application / x-tex">-C(O)S- or -C(O)NR_a-.< / annotation>< / semantics>< / com:Math>

[00137] Q

[00138] In one embodiment, Q is a chemical bond; in another embodiment, Q is -C(O)O-; in another embodiment, Q is -O-; in another embodiment, Q is -SC(O)O-; in another embodiment, Q is -OC(O)NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>C(O)NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -OC(O)S-; in another embodiment, Q is -OC(O)O-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>C(O)O-; in another embodiment, Q is -OC(O)-; in another embodiment, Q is -SC(O)-; in another embodiment, Q is -C(O)S-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -C(O)NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>C(O)-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>C(O)S-; in another embodiment, Q is -SC(O)NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -C(O)-; in another embodiment, Q is -OC(S)-; in another embodiment, Q is -C(S)O-; in another embodiment, Q is -OC(S)NR<com:Sub>b< / com:Sub>-; in another embodiment, Q is -NR<com:Sub>b< / com:Sub>C(S)O-; in another embodiment, Q is -S-S-; in another embodiment, Q is -S(O)<com:Sub>0-2< / com:Sub>-; in another embodiment, Q is phenylene; in another embodiment, Q is pyridylidene; in another embodiment, the phenylene or pyridylidene is optionally substituted with one or more R*.

[00139] In a more specific embodiment, Q is selected from a chemical bond, -C(O)O-, -O-, <com:Math><semantics>−SC(O)O−<annotation encoding="application / x-tex">-SC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)NRb−<annotation encoding="application / x-tex">-OC(O)NR_b-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(O)NRb−<annotation encoding="application / x-tex">-NR_bC(O)NR_b-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)S−<annotation encoding="application / x-tex">-OC(O)S-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)O−<annotation encoding="application / x-tex">-OC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(O)O−<annotation encoding="application / x-tex">-NR_bC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)−<annotation encoding="application / x-tex">-OC(O)-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRb<annotation encoding="application / x-tex">-NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRb<annotation encoding="application / x-tex">-C(O)NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)<annotation encoding="application / x-tex">-NR_bC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)S<annotation encoding="application / x-tex">-NR_bC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)NRb<annotation encoding="application / x-tex">-SC(O)NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)NRb<annotation encoding="application / x-tex">-OC(S)NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(S)O<annotation encoding="application / x-tex">-NR_bC(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−S<annotation encoding="application / x-tex">-S< / annotation>< / semantics>< / com:Math>-S-, and <com:Math><semantics>−S(O)0−2<annotation encoding="application / x-tex">-S(O)_{0-2}< / annotation>< / semantics>< / com:Math>-; in another more specific embodiment, Q is selected from -C(O)O-, -O-, -SC(O)O-, -OC(O)NH-, -NHC(O)NH-, -OC(O)S-, -OC(O)O-, -NHC(O)O-, -OC(O)-, -SC(O)-, -C(O)S-, -NH-, -C(O)NH-, -NHC(O)-, -NHC(O)S-, -SC(O)NH-, -C(O)-, -OC(S)-, -C(S)O-, -OC(S)NH- and -NHC(S)O-; in another more specific embodiment, Q is selected from -C(O)O-, -O-, -SC(O)O-, -OC(O)NH-, -NHC(O)NH-, -OC(O)S-, -OC(O)O- and -NHC(O)O-; in another more specific embodiment, <com:Math><semantics>Q<annotation encoding="application / x-tex">Q< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C(O)O−<annotation encoding="application / x-tex">-C(O)O-< / annotation>< / semantics>< / com:Math>.

[00140] G<com:Sub>5< / com:Sub>

[00141] In one embodiment, <com:Math><semantics>G5<annotation encoding="application / x-tex">G_5< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G5<annotation encoding="application / x-tex">G_5< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, G<com:Sub>5< / com:Sub> is optionally substituted with one or more R**.

[00142] G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub>

[00143] In one embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> linear alkylene; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>(CH2)2<annotation encoding="application / x-tex">(CH2)2< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G6a< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3 or 4 R**.

[00144] In one embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−2<annotation encoding="application / x-tex">C_{1-2}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is methylene; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3 or 4 <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1 or 2 <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math>.

[00145] In one embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 0 carbon atoms; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 1 carbon atom; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and G<com:Sub>6b< / com:Sub> have a total length of 2 carbon atoms; in another embodiment, G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 3 carbon atoms; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 4 carbon atoms; in another embodiment, G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 5 carbon atoms; in another embodiment, G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 6 carbon atoms; in another embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 7 carbon atoms.

[00146] In a more specific embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or C<com:Sub>1-5< / com:Sub> alkylene, which is optionally substituted with 1, 2, 3 or 4 R**; G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 0, 1, 2, 3, 4 or 5 carbon atoms.

[00147] In another more specific embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is a chemical bond or <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with 1, 2, 3 or 4 R**; G<com:Sub>6b< / com:Sub> is a chemical bond or C<com:Sub>1-2< / com:Sub> alkylene, which is optionally substituted with 1 or 2 R**; G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 0, 1, 2, 3 or 4 carbon atoms.

[00148] In another more specific embodiment, G<com:Sub>6a< / com:Sub> is a chemical bond or C<com:Sub>1-4< / com:Sub> alkylene, alternatively <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkylene, alternatively <com:Math><semantics>C2−3<annotation encoding="application / x-tex">C_{2-3}< / annotation>< / semantics>< / com:Math> alkylene, more alternatively -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is a chemical bond or methylene; G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 0, 1, 2, 3 or 4 carbon atoms, alternatively 1, 2, 3 or 4 carbon atoms, alternatively 2 or 3 carbon atoms.

[00149] In another more specific embodiment, <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> is a chemical bond or <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> linear alkylene, alternatively <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> linear alkylene, alternatively <com:Math><semantics>C2−3<annotation encoding="application / x-tex">C_{2-3}< / annotation>< / semantics>< / com:Math> linear alkylene, more alternatively -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> is a chemical bond or methylene; <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> have a total length of 0, 1, 2, 3 or 4 carbon atoms, alternatively 1, 2, 3 or 4 carbon atoms, alternatively 2 or 3 carbon atoms.

[00150] R<com:Sub>9< / com:Sub>

[00151] In one embodiment, R<com:Sub>9< / com:Sub> is H; in another embodiment, R<com:Sub>9< / com:Sub> is C<com:Sub>1-8< / com:Sub> alkyl; in another embodiment, R<com:Sub>9< / com:Sub> is -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>; in another embodiment, R<com:Sub>9< / com:Sub> is -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub>; in another embodiment, R<com:Sub>9< / com:Sub> is -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>; in another embodiment, R<com:Sub>9< / com:Sub> is C<com:Sub>1-6< / com:Sub> alkyl.

[00152] In a more specific embodiment, R<com:Sub>9< / com:Sub> is H, C<com:Sub>1-6< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>; in another more specific embodiment, R<com:Sub>9< / com:Sub> is H or C<com:Sub>1-6< / com:Sub> alkyl; in another more specific embodiment, R<com:Sub>9< / com:Sub> is H.

[00153] R<com:Sub>10< / com:Sub>

[00154] In one embodiment, <com:Math><semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sub>10< / com:Sub> is -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>; in another embodiment, R<com:Sub>10< / com:Sub> is -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub>; in another embodiment, R<com:Sub>10< / com:Sub> is -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>.

[00155] In a more specific embodiment, R<com:Sub>10< / com:Sub> is H, C<com:Sub>1-6< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>; in another more specific embodiment, <com:Math><semantics>R10<annotation encoding="application / x-tex">R_{10}< / annotation>< / semantics>< / com:Math> is H.

[00156] R**

[00157] In one embodiment, <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R** is -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>; in another embodiment, R** is -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub>; in another embodiment, R** is -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>; in another embodiment, R** is C<com:Sub>1-6< / com:Sub> alkyl.

[00158] In a more specific embodiment, R** is H, C<com:Sub>1-6< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>; in another more specific embodiment, <com:Math><semantics>R**<annotation encoding="application / x-tex">R^{**}< / annotation>< / semantics>< / com:Math> is H or <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another more specific embodiment, R** is H.

[00159] G<com:Sub>1< / com:Sub>, G<com:Sub>2< / com:Sub>, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub>

[00160] In one embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−13<annotation encoding="application / x-tex">C_{1-13}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenylene; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00161] In one embodiment, <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−13<annotation encoding="application / x-tex">C_{1-13}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenylene; in another embodiment, <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene; in another embodiment, <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00162] In one embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 3 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 4 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 5 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 6 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 7 carbon atoms; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 8 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 9 carbon atoms; in another embodiment, G<com:Sub>1< / com:Sub> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 10 carbon atoms; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 11 carbon atoms; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 12 carbon atoms; in another embodiment, <com:Math><semantics>G1<annotation encoding="application / x-tex">G_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math> have a total length of 13 carbon atoms.

[00163] In a more specific embodiment, <com:Math><semantics>−G1<annotation encoding="application / x-tex">-G_1< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>C(R5R6)<annotation encoding="application / x-tex">C(R_5R_6)< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>G2<annotation encoding="application / x-tex">G_2< / annotation>< / semantics>< / com:Math>- is <com:Math><semantics>C1a<annotation encoding="application / x-tex">C_{1a}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C1a<annotation encoding="application / x-tex">C_{1a}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C1b<annotation encoding="application / x-tex">C_{1b}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C2a<annotation encoding="application / x-tex">C_{2a}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>C2b<annotation encoding="application / x-tex">C_{2b}< / annotation>< / semantics>< / com:Math>

[00164] In one embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>6< / com:Sub>-; in another embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00165] In one embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00166] In one embodiment, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 R<com:Sup>s< / com:Sup>.

[00167] In one embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00168] In a more specific embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms; in another more specific embodiment, <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5 or 6 carbon atoms.

[00169] In one embodiment, one of L<com:Sub>3< / com:Sub> and L<com:Sub>5< / com:Sub> is -(<com:Math><semantics>CRsRs<annotation encoding="application / x-tex">CR^sR^s< / annotation>< / semantics>< / com:Math>')<com:Sub>2< / com:Sub>-, and the other is a chemical bond; in another embodiment, one of <com:Math><semantics>L3<annotation encoding="application / x-tex">L_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L5<annotation encoding="application / x-tex">L_5< / annotation>< / semantics>< / com:Math> is -(CHR<com:Sup>s< / com:Sup>)<com:Sub>2< / com:Sub>-, and the other is a chemical bond; in another embodiment, one of L<com:Sub>3< / com:Sub> and L<com:Sub>5< / com:Sub> is -CH=CH-, and the other is a chemical bond; in another embodiment, one of <com:Math><semantics>L3<annotation encoding="application / x-tex">L_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L5<annotation encoding="application / x-tex">L_5< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C≡C7<annotation encoding="application / x-tex">-C \equiv C_7< / annotation>< / semantics>< / com:Math>, and the other is a chemical bond.

[00170] In one embodiment, <com:Math><semantics>G3<annotation encoding="application / x-tex">G_3< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G3<annotation encoding="application / x-tex">G_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−13<annotation encoding="application / x-tex">C_{1-13}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G3<annotation encoding="application / x-tex">G_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenylene; in another embodiment, <com:Math><semantics>G3<annotation encoding="application / x-tex">G_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene; in another embodiment, G<com:Sub>3< / com:Sub> is optionally substituted with one or more R<com:Sup>s< / com:Sup>.

[00171] In one embodiment, <com:Math><semantics>G4<annotation encoding="application / x-tex">G_4< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G4<annotation encoding="application / x-tex">G_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−13<annotation encoding="application / x-tex">C_{1-13}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G4<annotation encoding="application / x-tex">G_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkenylene; in another embodiment, <com:Math><semantics>G4<annotation encoding="application / x-tex">G_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene; in another embodiment, G<com:Sub>4< / com:Sub> is optionally substituted with one or more R<com:Sup>s< / com:Sup>.

[00172] In one embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 3 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 4 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 5 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 6 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 7 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 8 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 9 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 10 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 11 carbon atoms; in another embodiment, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 12 carbon atoms; in another embodiment, <com:Math><semantics>G3<annotation encoding="application / x-tex">G_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4<annotation encoding="application / x-tex">G_4< / annotation>< / semantics>< / com:Math> have a total length of 13 carbon atoms. [Image disponible dans le document PDF, Image available in the PDF document]

[00173] In a more specific embodiment,

[00174] In one embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>6< / com:Sub>-; in another embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00175] In one embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−CH2−<annotation encoding="application / x-tex">-CH_{2-}< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>.

[00176] In one embodiment, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 R<com:Sup>s< / com:Sup>.

[00177] In one embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-; in another embodiment, G<com:Sub>4b< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R<com:Sup>s< / com:Sup>;

[00178] In a more specific embodiment, <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms; in another more specific embodiment, G<com:Sub>3a< / com:Sub>, G<com:Sub>3b< / com:Sub>, G<com:Sub>4a< / com:Sub> and G<com:Sub>4b< / com:Sub> have a total length of 1, 2, 3, 4, 5 or 6 carbon atoms.

[00179] In one embodiment, one of <com:Math><semantics>L4<annotation encoding="application / x-tex">L_4< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L6<annotation encoding="application / x-tex">L_6< / annotation>< / semantics>< / com:Math> is -(CR<com:Sup>s< / com:Sup>R<com:Sup>s< / com:Sup>')<com:Sub>2< / com:Sub>-, and the other is a chemical bond; in another embodiment, one of <com:Math><semantics>L4<annotation encoding="application / x-tex">L_4< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L6<annotation encoding="application / x-tex">L_6< / annotation>< / semantics>< / com:Math> is -(CHR<com:Sup>s< / com:Sup>)<com:Sub>2< / com:Sub>-, and the other is a chemical bond; in another embodiment, one of L<com:Sub>4< / com:Sub> and L<com:Sub>6< / com:Sub> is -CH=CH-, and the other is a chemical bond; in another embodiment, one of <com:Math><semantics>L4<annotation encoding="application / x-tex">L_4< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L6<annotation encoding="application / x-tex">L_6< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C≡C−<annotation encoding="application / x-tex">-C \equiv C_-< / annotation>< / semantics>< / com:Math>, and the other is a chemical bond.

[00180] In a more specific embodiment, one of L<com:Sub>3< / com:Sub> and L<com:Sub>5< / com:Sub>, or one of L<com:Sub>4< / com:Sub> and L<com:Sub>6< / com:Sub> is -(CHR<com:Sup>s< / com:Sup>)<com:Sub>2< / com:Sub>-, -CH=CH- or -C≡C-, and the other is a chemical bond;

[00181] <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene;

[00182] <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene;

[00183] <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene;

[00184] <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>< / com:Math> alkylene;

[00185] <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms;

[00186] <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms.

[00187] In another more specific embodiment, one of <com:Math><semantics>L3<annotation encoding="application / x-tex">L_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L5<annotation encoding="application / x-tex">L_5< / annotation>< / semantics>< / com:Math>, or one of <com:Math><semantics>L4<annotation encoding="application / x-tex">L_4< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L6<annotation encoding="application / x-tex">L_6< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -CH=CH- or -C<com:Math><semantics>≡<annotation encoding="application / x-tex">\equiv< / annotation>< / semantics>< / com:Math>C-, and the other is a chemical bond;

[00188] G<com:Sub>1a< / com:Sub> and G<com:Sub>3a< / com:Sub> are independently a chemical bond, -CH<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-, <com:Math><semantics>−(CH2)5<annotation encoding="application / x-tex">-(CH_2)_5< / annotation>< / semantics>< / com:Math>- or <com:Math><semantics>−(CH2)6<annotation encoding="application / x-tex">-(CH_2)_6< / annotation>< / semantics>< / com:Math>-;

[00189] <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math> is a chemical bond;

[00190] <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> is a chemical bond;

[00191] G<com:Sub>2b< / com:Sub> and G<com:Sub>4b< / com:Sub> are independently a chemical bond, -CH<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>- or -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-;

[00192] <com:Math><semantics>G1a<annotation encoding="application / x-tex">G_{1a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G1b<annotation encoding="application / x-tex">G_{1b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G2a<annotation encoding="application / x-tex">G_{2a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G2b<annotation encoding="application / x-tex">G_{2b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5 or 6 carbon atoms;

[00193] <com:Math><semantics>G3a<annotation encoding="application / x-tex">G_{3a}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G3b<annotation encoding="application / x-tex">G_{3b}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G4a<annotation encoding="application / x-tex">G_{4a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G4b<annotation encoding="application / x-tex">G_{4b}< / annotation>< / semantics>< / com:Math> have a total length of 1, 2, 3, 4, 5 or 6 carbon atoms.

[00194] Alternatively, R<com:Sup>s< / com:Sup> and R<com:Sup>s< / com:Sup>' are independently H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>d< / com:Sub>-OR<com:Sub>d< / com:Sub> or -L<com:Sub>d< / com:Sub>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>; alternatively H or <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; more alternatively H.

[00195] In a more specific embodiment, -G<com:Sub>1a< / com:Sub>-L<com:Sub>3< / com:Sub>-G<com:Sub>1b< / com:Sub>- or -G<com:Sub>3a< / com:Sub>-L<com:Sub>4< / com:Sub>-G<com:Sub>3b< / com:Sub>- is independently selected from: <com:Math><semantics>−(CH2)2<annotation encoding="application / x-tex">-(CH_2)_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)3<annotation encoding="application / x-tex">-(CH_2)_3< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)4<annotation encoding="application / x-tex">-(CH_2)_4< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)5<annotation encoding="application / x-tex">-(CH_2)_5< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)6<annotation encoding="application / x-tex">-(CH_2)_6< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)7<annotation encoding="application / x-tex">-(CH_2)_7< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)8<annotation encoding="application / x-tex">-(CH_2)_8< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)3−CH=CH−<annotation encoding="application / x-tex">-(CH_2)_3-CH=CH-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3−C≡C−<annotation encoding="application / x-tex">-(CH_2)_3-C\equiv C-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2−CH=CH−<annotation encoding="application / x-tex">-(CH_2)_2-CH=CH-< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−(CH2)2−C≡C−<annotation encoding="application / x-tex">-(CH_2)_2-C\equiv C-< / annotation>< / semantics>< / com:Math>.

[00196] In a more specific embodiment, -G<com:Sub>2a< / com:Sub>-L<com:Sub>5< / com:Sub>-G<com:Sub>2b< / com:Sub>- or -G<com:Sub>4a< / com:Sub>-L<com:Sub>6< / com:Sub>-G<com:Sub>4b< / com:Sub>- is independently selected from: a chemical bond, <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)2<annotation encoding="application / x-tex">-(CH_2)_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−(CH2)3<annotation encoding="application / x-tex">-(CH_2)_3< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CH=CH−CH2<annotation encoding="application / x-tex">-CH=CH-CH_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C≡C<annotation encoding="application / x-tex">-C\equiv C< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−C≡C−CH2−.<annotation encoding="application / x-tex">-C \equiv C - CH_2 - .< / annotation>< / semantics>< / com:Math>

[00197] In a more specific embodiment, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>A_{G_{1a}} A_{G_{1b}} A_{G_{2a}} A_{G_{2b}} A_{G_{2b}} A_{G_{3b}} A_{G_{4a}} A_{G_{3b}} A_{G_{4a}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_ a total length of 4, 5, 6, 7, 8 or 9 carbon atoms.

[00198] In a more specific embodiment, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>A_{G_{1a}} A_{G_{1b}} A_{G_{2a}} A_{G_{2b}} A_{G_{2b}} A_{G_{3b}} A_{G_{3b}} A_{G_{4a}} A_{G_{3b}} A_{G_{4a}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_ independently selected from: <com:Math><semantics>−(CH2)3−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_3-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)4−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_4-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)5−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_5-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)6−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_6-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)7−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_7-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)8−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_8-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3−CH=CH−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_3-CH=CH-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3−C≡C−C(CH3)2−,<annotation encoding="application / x-tex">-(CH_2)_3-C\equiv C-C(CH_3)_2-,< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−(CH2)4−C(CH3)2−CH2−,<annotation encoding="application / x-tex">-(CH_2)_4-C(CH_3)_2-CH_2-,< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−(CH2)3−C(CH3)2−(CH2)2−,<annotation encoding="application / x-tex">-(CH_2)_3-C(CH_3)_2-(CH_2)_2-,< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−(CH2)2−C(CH3)2−(CH2)3−<annotation encoding="application / x-tex">-(CH_2)_2-C(CH_3)_2-(CH_2)_3-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2−CH=CH−C(CH3)2−CH2−<annotation encoding="application / x-tex">-(CH_2)_2-CH=CH-C(CH_3)_2-CH_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2−C(CH3)2−C≡C−CH2−<annotation encoding="application / x-tex">-(CH_2)_2-C(CH_3)_2-C\equiv C-CH_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2−C(CH3)2−CH=CH−CH2−<annotation encoding="application / x-tex">-(CH_2)_2-C(CH_3)_2-CH=CH-CH_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2−C≡C−C(CH3)2−CH2−<annotation encoding="application / x-tex">-(CH_2)_2-C\equiv C-C(CH_3)_2-CH_2-< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−(CH2)3−C(CH3)2−C≡C−<annotation encoding="application / x-tex">-(CH_2)_3-C(CH_3)_2-C\equiv C-< / annotation>< / semantics>< / com:Math>; in another more specific embodiment, <com:Math><semantics>AG1aAG1bAG2aAG2bAG2bAG3bAG4aAG4bAG4bAG4bAG4bAG4bAG4bAG4bAG4bAG4bAG4b<annotation encoding="application / x-tex">A_{G_{1a}} A_{G_{1b}} A_{G_{2a}} A_{G_{2b}} A_{G_{2b}} A_{G_{3b}} A_{G_{4a}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}} A_{G_{4b}}< / annotation>< / semantics>< / com:Math> independently <com:Math><semantics>−(CH2)4−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_4-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)5−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_5-C(CH_3)_2-< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−(CH2)6−C(CH3)2−<annotation encoding="application / x-tex">-(CH_2)_6-C(CH_3)_2-< / annotation>< / semantics>< / com:Math>; in another more specific embodiment, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$A_{G_{1a}} \xrightarrow{R_5} A_{G_{2a}} \xrightarrow{R_5} A_{G_{2b}} = A_{G_{3b}} \xrightarrow{R_7} A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_{G_{4b}} = A_$

[00199] R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub>

[00200] In one embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is 3- to 14-membered cycloalkyl; in another embodiment, R<com:Sub>3< / com:Sub> is 3- to 14-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub> is <com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is 5- to 14-membered heteroaryl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, R<com:Sub>3< / com:Sub> is 3- to 10-membered cycloalkyl; in another embodiment, R<com:Sub>3< / com:Sub> is 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub> is 3- to 7-membered cycloalkyl; in another embodiment, R<com:Sub>3< / com:Sub> is 3- to 7-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub> is Me; in another embodiment, R<com:Sub>3< / com:Sub> is -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>; in another embodiment, R<com:Sub>3< / com:Sub> is -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OH; in another embodiment, R<com:Sub>3< / com:Sub> is -CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>; in another embodiment, R<com:Sub>3< / com:Sub> is substituted with one or more <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is optionally substituted with 1, 2, 3, 4 or 5 <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math>.

[00201] In one embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is 3- to 14-membered cycloalkyl; in another embodiment, R<com:Sub>4< / com:Sub> is 3- to 14-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub> is <com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is 5- to 14-membered heteroaryl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, R<com:Sub>4< / com:Sub> is 3- to 10-membered cycloalkyl; in another embodiment, R<com:Sub>4< / com:Sub> is 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub> is 3- to 7-membered cycloalkyl; in another embodiment, R<com:Sub>4< / com:Sub> is 3- to 7-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub> is Me; in another embodiment, R<com:Sub>4< / com:Sub> is substituted with one or more R*; in another embodiment, R<com:Sub>4< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00202] In one embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 14-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 7-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 5- to 7-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 4- to 6-membered heterocyclyl; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 5-membered heterocyclyl; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are taken together with the N atom to which they are attached to form <com:Math><semantics>○N<annotation encoding="application / x-tex">\bigcirc^{N}< / annotation>< / semantics>< / com:Math>; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form <com:Math><semantics>⋂N<annotation encoding="application / x-tex">\bigcap^{N}< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are taken together with the N atom to which [Image disponible dans le document PDF, Image available in the PDF document] they are attached to form ; in another embodiment, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form <com:Math><semantics>○N<annotation encoding="application / x-tex">\bigcirc^{N}< / annotation>< / semantics>< / com:Math>; in another embodiment, the heterocyclyl formed by R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> taken together with the N atom to which they are attached is optionally substituted with one or more R*; in another embodiment, the heterocyclyl formed by R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> taken together with the N atom to which they are attached is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00203] In one embodiment, R<com:Sub>4< / com:Sub>, R<com:Sub>9< / com:Sub> are taken together with the atom to which they are attached to form 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl; in another embodiment, R<com:Sub>4< / com:Sub>, R<com:Sub>9< / com:Sub> are taken together with the atom to which they are attached to form 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub>, R<com:Sub>9< / com:Sub> are taken together with the atom to which they are attached to form 3- to 7-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub>, R<com:Sub>9< / com:Sub> are taken together with the atom to which they are attached to form 6-membered heterocyclyl; in another embodiment, R<com:Sub>4< / com:Sub>, R<com:Sub>9< / com:Sub> are taken together with the atom to which they [Image disponible dans le document PDF, Image available in the PDF document] are attached to form ; in another embodiment, the heterocyclyl formed by R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> taken together with the atom to which they are attached is optionally substituted with one or more R*; in another embodiment, the heterocyclyl formed by R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> taken together with the atom to which they are attached is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00204] In a more specific embodiment, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are independently H, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00205] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00206] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3 or 4 R*.

[00207] In another more specific embodiment, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are independently H, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, 3- to 7-membered cycloalkyl or 3- to 7-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00208] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 7-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00209] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 3- to 7-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00210] In a more specific embodiment, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00211] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 5- to 7-membered heterocyclyl, alternatively 4- to 6-membered heterocyclyl, more alternatively 5-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*;

[00212] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 6-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00213] In a more specific embodiment, R<com:Sub>3< / com:Sub> is Me, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OH or -CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, alternatively Me, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> or -CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, more alternatively Me or -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>; R<com:Sub>4< / com:Sub> is Me;

[00214] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form <com:Math><semantics>○Nλ<annotation encoding="application / x-tex">\bigcirc_{N}^{\lambda}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>○Nλ<annotation encoding="application / x-tex">\bigcirc_{N}^{\lambda}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>○Nλ<annotation encoding="application / x-tex">\bigcirc_{N}^{\lambda}< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>○Nλ<annotation encoding="application / x-tex">\bigcirc_{N}^{\lambda}< / annotation>< / semantics>< / com:Math>, alternatively [Image disponible dans le document PDF, Image available in the PDF document] , more alternatively

[00215] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form

[00216] R*

[00217] In one embodiment, R* is H; in another embodiment, R* is halogen; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is cyano; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−Lb<annotation encoding="application / x-tex">-L_b< / annotation>< / semantics>< / com:Math>-<com:Math><semantics>ORb<annotation encoding="application / x-tex">OR_b< / annotation>< / semantics>< / com:Math>; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is -L<com:Sub>b< / com:Sub>-SR<com:Sub>b< / com:Sub>; in another embodiment, R* is -L<com:Sub>b< / com:Sub>-NR<com:Sub>b< / com:Sub>R'<com:Sub>b< / com:Sub>; in another embodiment, R* is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl; in another embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−ORb<annotation encoding="application / x-tex">-OR_b< / annotation>< / semantics>< / com:Math>.

[00218] In a more specific embodiment, R* is independently H, halogen, cyano, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, -L<com:Sub>b< / com:Sub>-OR<com:Sub>b< / com:Sub> or -L<com:Sub>b< / com:Sub>-NR<com:Sub>b< / com:Sub>R'<com:Sub>b< / com:Sub>; in another more specific embodiment, R* is independently H, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl or -OR<com:Sub>b< / com:Sub>; in another more specific embodiment, R* is independently H, halogen, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl; in another more specific embodiment, <com:Math><semantics>R*<annotation encoding="application / x-tex">R^*< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl; in another more specific embodiment, R* is H, Me or OH; in another more specific embodiment, R* is H or Me.

[00219] R<com:Sub>5< / com:Sub>, R<com:Sub>6< / com:Sub>, R<com:Sub>7< / com:Sub> and R<com:Sub>8< / com:Sub>

[00220] In one embodiment, <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R5<annotation encoding="application / x-tex">R_5< / annotation>< / semantics>< / com:Math> is Me; in another embodiment, R<com:Sub>5< / com:Sub> is optionally substituted with one or more R*; in another embodiment, R<com:Sub>5< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00221] In one embodiment, <com:Math><semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R6<annotation encoding="application / x-tex">R_6< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sub>6< / com:Sub> is C<com:Sub>1-3< / com:Sub> alkyl; in another embodiment, R<com:Sub>6< / com:Sub> is Me; in another embodiment, R<com:Sub>6< / com:Sub> is optionally substituted with one or more R*; in another embodiment, R<com:Sub>6< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00222] In one embodiment, <com:Math><semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R7<annotation encoding="application / x-tex">R_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sub>7< / com:Sub> is C<com:Sub>1-3< / com:Sub> alkyl; in another embodiment, R<com:Sub>7< / com:Sub> is Me; in another embodiment, R<com:Sub>7< / com:Sub> is optionally substituted with one or more R*; in another embodiment, R<com:Sub>7< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00223] In one embodiment, <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R8<annotation encoding="application / x-tex">R_8< / annotation>< / semantics>< / com:Math> is Me; in another embodiment, R<com:Sub>8< / com:Sub> is optionally substituted with one or more R*; in another embodiment, R<com:Sub>8< / com:Sub> is optionally substituted with 1, 2, 3, 4 or 5 R*.

[00224] R<com:Sub>1< / com:Sub> and R<com:Sub>2< / com:Sub>

[00225] In one embodiment, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl; in another embodiment, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl; in another embodiment, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more R; in another embodiment, one or more methylene units in <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> are optionally and independently replaced by -NR''-.

[00226] In a more specific embodiment, R<com:Sub>1< / com:Sub> is -G<com:Sub>7< / com:Sub>-L<com:Sub>1< / com:Sub>-G<com:Sub>8< / com:Sub>-H.

[00227] In one embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> linear alkylene; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, G<com:Sub>7< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-; in another embodiment, G<com:Sub>7< / com:Sub> is optionally substituted with 1, 2, 3, 4, 5 or 6 R; in another embodiment, 1, 2 or 3 methylenes in G<com:Sub>7< / com:Sub> are optionally and independently substituted with 1 R; in another embodiment, 1 or 2 methylenes in G<com:Sub>7< / com:Sub> are optionally and independently substituted with 1 R; in another embodiment, the methylene of <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> that is collected to <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> is not substituted with R.

[00228] In one embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> linear alkylene; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, G<com:Sub>8< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, G<com:Sub>8< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>6< / com:Sub>-; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>7< / com:Sub>-; in another embodiment, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>-; in another embodiment, G<com:Sub>8< / com:Sub> is optionally substituted with 1, 2, 3, 4, 5 or 6 R; in another embodiment, 1, 2 or 3 methylenes in G<com:Sub>8< / com:Sub> are optionally and independently substituted with 1 R; in another embodiment, 1 or 2 alkylene in G<com:Sub>8< / com:Sub> are optionally and independently substituted with 1 R.

[00229] In one embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 4 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 5 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 6 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 7 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 8 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 9 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 10 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 11 carbon atoms; in another embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 12 carbon atoms.

[00230] In a more specific embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 6, 7, 8, 9 or 10 carbon atoms.

[00231] In a more specific embodiment, G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 6, 7 or 8 carbon atoms.

[00232] In one embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -(CRR')<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -CH=CH-; in another embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -C=C-; in another embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -NR"-; in another embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -(CHR)<com:Sub>2< / com:Sub>-.

[00233] In one embodiment, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl; in another embodiment, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl; in another embodiment, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is optionally substituted with one or more R; in another embodiment, one or more methylene units in <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> are optionally and independently replaced by -NR''-.

[00234] In a more specific embodiment, R<com:Sub>2< / com:Sub> is -G<com:Sub>9< / com:Sub>-L<com:Sub>2< / com:Sub>-G<com:Sub>10< / com:Sub>-H.

[00235] In one embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> linear alkylene; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-; in another embodiment, G<com:Sub>9< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, G<com:Sub>9< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, G<com:Sub>9< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-; in another embodiment, G<com:Sub>9< / com:Sub> is optionally substituted with 1, 2, 3, 4, 5 or 6 R; in another embodiment, 1, 2 or 3 methylenes in G<com:Sub>9< / com:Sub> are optionally and independently substituted with 1 R; in another embodiment, 1 or 2 methylenes in G<com:Sub>9< / com:Sub> are optionally and independently substituted with 1 R; in another embodiment, the methylene of G<com:Sub>9< / com:Sub> that is collected to M<com:Sub>2< / com:Sub> is not substituted with R.

[00236] In one embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−12<annotation encoding="application / x-tex">C_{1-12}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> linear alkylene; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>6< / com:Sub>-; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>7< / com:Sub>-; in another embodiment, <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>-; in another embodiment, G<com:Sub>10< / com:Sub> is optionally substituted with 1, 2, 3, 4, 5 or 6 R; in another embodiment, 1, 2 or 3 methylenes in <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are optionally and independently substituted with 1 R; in another embodiment, 1 or 2 methylenes in <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are optionally and independently substituted with 1 R.

[00237] In one embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> have a total length of 4 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 5 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 6 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 7 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 8 carbon atoms; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> have a total length of 9 carbon atoms; in another embodiment, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> have a total length of 10 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 11 carbon atoms; in another embodiment, G<com:Sub>9< / com:Sub> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> have a total length of 12 carbon atoms.

[00238] In a more specific embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 6, 7, 8, 9 or 10 carbon atoms.

[00239] In a more specific embodiment, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 6, 7 or 8 carbon atoms.

[00240] In one embodiment, L<com:Sub>2< / com:Sub> is -(CRR')<com:Sub>2< / com:Sub>-; in another embodiment, L<com:Sub>2< / com:Sub> is -CH=CH-; in another embodiment, <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> is -C=C-; in another embodiment, <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> is -NR"-; in another embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> is -(CHR)<com:Sub>2< / com:Sub>-.

[00241] In a more specific embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> are independently -(CRR')<com:Sub>2< / com:Sub>-, -CH=CH-, -C≡C- or -NR”-;

[00242] G<com:Sub>7< / com:Sub>, G<com:Sub>8< / com:Sub>, G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> are independently a chemical bond or C<com:Sub>1-12< / com:Sub> alkylene, which is optionally substituted with 1, 2, 3, 4, 5 or 6 R;

[00243] G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms;

[00244] G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms;

[00245] 1, 2 or 3 methylenes in G<com:Sub>7< / com:Sub>, G<com:Sub>8< / com:Sub>, G<com:Sub>9< / com:Sub> or G<com:Sub>10< / com:Sub> are optionally and independently substituted with 1 R;

[00246] R' is independently H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>a< / com:Sub>-OR<com:Sub>a< / com:Sub> or -L<com:Sub>a< / com:Sub>-NR<com:Sub>a< / com:Sub>R'<com:Sub>a< / com:Sub>.

[00247] In another more specific embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> are independently -(CHR)<com:Sub>2< / com:Sub>-, -CH=CH-, -C≡C- or -NR"-;

[00248] G<com:Sub>7< / com:Sub> and G<com:Sub>9< / com:Sub> are independently a chemical bond or C<com:Sub>1-6< / com:Sub> alkylene;

[00249] <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene;

[00250] <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> have a total length of 4, 5, 6, 7, 8, 9 or 10 carbon atoms;

[00251] G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9 or 10 carbon atoms;

[00252] 1, 2 or 3 methylenes in <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are optionally and independently substituted with 1 R.

[00253] In another more specific embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> are independently -(CHR)<com:Sub>2< / com:Sub>-, -CH=CH-, -C≡C- or -NR"-;

[00254] G<com:Sub>7< / com:Sub> and G<com:Sub>9< / com:Sub> are independently a chemical bond or C<com:Sub>1-5< / com:Sub> alkylene, alternatively a chemical bond or <com:Math><semantics>C1−5<annotation encoding="application / x-tex">C_{1-5}< / annotation>< / semantics>< / com:Math> linear alkylene;

[00255] <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene, alternatively <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> linear alkylene;

[00256] G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10 carbon atoms, alternatively 6, 7, 8, 9, 10 carbon atoms;

[00257] G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10 carbon atoms, alternatively 6, 7, 8, 9, 10 carbon atoms;

[00258] 1 or 2 methylenes in <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are optionally and independently substituted with 1 R.

[00259] Alternatively, the methylene collected to <com:Math><semantics>M1<annotation encoding="application / x-tex">M_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>M2<annotation encoding="application / x-tex">M_2< / annotation>< / semantics>< / com:Math> is not substituted with R.

[00260] In another more specific embodiment, <com:Math><semantics>L1<annotation encoding="application / x-tex">L_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>L2<annotation encoding="application / x-tex">L_2< / annotation>< / semantics>< / com:Math> are independently -(CHR)<com:Sub>2< / com:Sub>-, -CH=CH-, -C≡C- or -NR"-;

[00261] G<com:Sub>7< / com:Sub> and G<com:Sub>9< / com:Sub> are independently a chemical bond, -CH<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>- or -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-;

[00262] <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are independently -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>6< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>7< / com:Sub>- or -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>-;

[00263] G<com:Sub>7< / com:Sub> and G<com:Sub>8< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10 carbon atoms, alternatively 6, 7, 8, 9, 10 carbon atoms;

[00264] G<com:Sub>9< / com:Sub> and G<com:Sub>10< / com:Sub> have a total length of 4, 5, 6, 7, 8, 9, 10 carbon atoms, alternatively 6, 7, 8, 9, 10 carbon atoms;

[00265] 1 or 2 methylenes in <com:Math><semantics>G7<annotation encoding="application / x-tex">G_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G8<annotation encoding="application / x-tex">G_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>G9<annotation encoding="application / x-tex">G_9< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>G10<annotation encoding="application / x-tex">G_{10}< / annotation>< / semantics>< / com:Math> are optionally and independently substituted with 1 R.

[00266] Alternatively, the methylene collected to M<com:Sub>1< / com:Sub> and M<com:Sub>2< / com:Sub> is not substituted with R. [Image disponible dans le document PDF, Image available in the PDF document]

[00268] R<com:Sup>s< / com:Sup>

[00269] In one embodiment, <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sup>s< / com:Sup> is -L<com:Sub>d< / com:Sub>-OR<com:Sub>d< / com:Sub>; in another embodiment, R<com:Sup>s< / com:Sup> is -L<com:Sub>d< / com:Sub>-SR<com:Sub>d< / com:Sub>; in another embodiment, R<com:Sup>s< / com:Sup> is -L<com:Sub>d< / com:Sub>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>; in another embodiment, R<com:Sup>s< / com:Sup> is C<com:Sub>1-10< / com:Sub> alkyl; in another embodiment, R<com:Sup>s< / com:Sup> is C<com:Sub>1-6< / com:Sub> alkyl.

[00270] In a more specific embodiment, R<com:Sup>s< / com:Sup> is H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>d< / com:Sub>-OR<com:Sub>d< / com:Sub> or -L<com:Sub>d< / com:Sub>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>; in another more specific embodiment, <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math> is H or <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl.

[00271] R

[00272] In one embodiment, R is H; in another embodiment, R is <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R is -La-ORa; in another embodiment, R is -La-SRa; in another embodiment, R is -L<com:Sub>a< / com:Sub>-NR<com:Sub>a< / com:Sub>R'<com:Sub>a< / com:Sub>; in another embodiment, R is C<com:Sub>1-10< / com:Sub> alkyl; in another embodiment, R is C<com:Sub>1-8< / com:Sub> alkyl; in another embodiment, R is <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> linear alkyl.

[00273] In a more specific embodiment, R is H, Me, -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>CH<com:Sub>3< / com:Sub>, -(CH<com:Sub>2< / com:Sub>)<com:Sub>4< / com:Sub>CH<com:Sub>3< / com:Sub>, -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>CH<com:Sub>3< / com:Sub>, <com:Math><semantics>−(CH2)6CH3<annotation encoding="application / x-tex">-(CH_2)_6CH_3< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−(CH2)7CH3<annotation encoding="application / x-tex">-(CH_2)_7CH_3< / annotation>< / semantics>< / com:Math>.

[00274] R"

[00275] In one embodiment, R'' is H; in another embodiment, R'' is C<com:Sub>1-20< / com:Sub> alkyl; in another embodiment, R'' is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R'' is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R'' is C<com:Sub>7-9< / com:Sub> alkyl; in another embodiment, R'' is -(CH<com:Sub>2< / com:Sub>)<com:Sub>7< / com:Sub>CH<com:Sub>3< / com:Sub>.

[00276] L<com:Sub>a< / com:Sub> and L<com:Sub>e< / com:Sub>

[00277] In one embodiment, L<com:Sub>a< / com:Sub> and L<com:Sub>e< / com:Sub> are independently a chemical bond; in another embodiment, L<com:Sub>a< / com:Sub> and L<com:Sub>e< / com:Sub> are independently C<com:Sub>1-20< / com:Sub> alkylene; in another embodiment, L<com:Sub>a< / com:Sub> and L<com:Sub>e< / com:Sub> are independently <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>La<annotation encoding="application / x-tex">L_a< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Le<annotation encoding="application / x-tex">L_e< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene.

[00278] <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math>

[00279] In one embodiment, L<com:Sub>b< / com:Sub> and L<com:Sub>f< / com:Sub> are independently a chemical bond; in another embodiment, <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene.

[00280] L<com:Sub>c< / com:Sub>

[00281] In one embodiment, L<com:Sub>c< / com:Sub> is a chemical bond; in another embodiment, L<com:Sub>c< / com:Sub> is C<com:Sub>1-8< / com:Sub> alkylene; in another embodiment, <com:Math><semantics>Lc<annotation encoding="application / x-tex">L_c< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene.

[00282] L<com:Sub>d< / com:Sub>

[00283] In one embodiment, <com:Math><semantics>Ld<annotation encoding="application / x-tex">L_d< / annotation>< / semantics>< / com:Math> is a chemical bond; in another embodiment, <com:Math><semantics>Ld<annotation encoding="application / x-tex">L_d< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkylene; in another embodiment, <com:Math><semantics>Ld<annotation encoding="application / x-tex">L_d< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene.

[00284] R<com:Sub>a< / com:Sub> and R'<com:Sub>a< / com:Sub>

[00285] In one embodiment, Ra is H; in another embodiment, Ra is C<com:Sub>1-20< / com:Sub> alkyl; in another embodiment, R<com:Sub>a< / com:Sub> is 3- to 14-membered cycloalkyl; in another embodiment, R<com:Sub>a< / com:Sub> is 3- to 14-membered heterocyclyl; in another embodiment, R<com:Sub>a< / com:Sub> is C<com:Sub>1-14< / com:Sub> alkyl; in another embodiment, <com:Math><semantics>Ra<annotation encoding="application / x-tex">R_a< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>Ra<annotation encoding="application / x-tex">R_a< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C8−10<annotation encoding="application / x-tex">C_{8-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>Ra<annotation encoding="application / x-tex">R_a< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C8−10<annotation encoding="application / x-tex">C_{8-10}< / annotation>< / semantics>< / com:Math> linear alkyl; in another embodiment, R<com:Sub>a< / com:Sub> is -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>CH<com:Sub>3< / com:Sub>; in another embodiment, R<com:Sub>a< / com:Sub> is optionally substituted with one or more of the following substituents: H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>e< / com:Sub>-OR<com:Sub>e< / com:Sub>, -Le-SRe and -Le-NReR'e.

[00286] In one embodiment, R'a is H; in another embodiment, R'a is C<com:Sub>1-20< / com:Sub> alkyl; in another embodiment, R'a is 3- to 14-membered cycloalkyl; in another embodiment, R'a is 3- to 14-membered heterocyclyl; in another embodiment, R'a is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>Ra′<annotation encoding="application / x-tex">R'_a< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>Ra′<annotation encoding="application / x-tex">R'_a< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C8−10<annotation encoding="application / x-tex">C_{8-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, <com:Math><semantics>Ra′<annotation encoding="application / x-tex">R'_a< / annotation>< / semantics>< / com:Math> is C<com:Sub>8-10< / com:Sub> linear alkyl; in another embodiment, R'a is -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>CH<com:Sub>3< / com:Sub>; in another embodiment, R'a is optionally substituted with one or more of the following substituents: H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>e< / com:Sub>-OR<com:Sub>e< / com:Sub>, -Le-SRe and -Le-NReR'e.

[00287] R<com:Sub>b< / com:Sub> and R'<com:Sub>b< / com:Sub>

[00288] In one embodiment, <com:Math><semantics>Rb<annotation encoding="application / x-tex">R_b< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>Rb<annotation encoding="application / x-tex">R_b< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sub>b< / com:Sub> is 3- to 14-membered cycloalkyl; in another embodiment, R<com:Sub>b< / com:Sub> is 3- to 14-membered heterocyclyl; in another embodiment, R<com:Sub>b< / com:Sub> is C<com:Sub>1-6< / com:Sub> alkyl; in another embodiment, R<com:Sub>b< / com:Sub> is 3- to 10-membered cycloalkyl; in another embodiment, R<com:Sub>b< / com:Sub> is 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>b< / com:Sub> is optionally substituted with one or more of the following substituents: H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>f< / com:Sub>-OR<com:Sub>f< / com:Sub>, -L<com:Sub>f< / com:Sub>-SR<com:Sub>f< / com:Sub> and -L<com:Sub>f< / com:Sub>-NR<com:Sub>f< / com:Sub>R'<com:Sub>f< / com:Sub>.

[00289] In one embodiment, R'<com:Sub>b< / com:Sub> is H; in another embodiment, R'<com:Sub>b< / com:Sub> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R'<com:Sub>b< / com:Sub> is 3- to 14-membered cycloalkyl; in another embodiment, R'<com:Sub>b< / com:Sub> is 3- to 14-membered heterocyclyl; in another embodiment, <com:Math><semantics>Rb′<annotation encoding="application / x-tex">R'_b< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R'<com:Sub>b< / com:Sub> is 3- to 10-membered cycloalkyl; in another embodiment, R'<com:Sub>b< / com:Sub> is 3- to 10-membered heterocyclyl; in another embodiment, R<com:Sub>b< / com:Sub> is optionally substituted with one or more of the following substituents: H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>f< / com:Sub>-OR<com:Sub>f< / com:Sub>, -L<com:Sub>f< / com:Sub>-SR<com:Sub>f< / com:Sub> and -L<com:Sub>f< / com:Sub>-NR<com:Sub>f< / com:Sub>R'<com:Sub>f< / com:Sub>.

[00290] R<com:Sub>c< / com:Sub> and R'<com:Sub>c< / com:Sub>

[00291] In one embodiment, R<com:Sub>c< / com:Sub> is H; in another embodiment, R<com:Sub>c< / com:Sub> is C<com:Sub>1-8< / com:Sub> alkyl; in another embodiment, <com:Math><semantics>Rc<annotation encoding="application / x-tex">R_c< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl.

[00292] In one embodiment, R'c is H; in another embodiment, R'c is C<com:Sub>1-8< / com:Sub> alkyl; in another embodiment, R'c is C<com:Sub>1-6< / com:Sub> alkyl.

[00293] R<com:Sub>d< / com:Sub> and R'<com:Sub>d< / com:Sub>

[00294] In one embodiment, <com:Math><semantics>Rd<annotation encoding="application / x-tex">R_d< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>Rd<annotation encoding="application / x-tex">R_d< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R<com:Sub>d< / com:Sub> is C<com:Sub>1-10< / com:Sub> alkyl. In one embodiment, R'<com:Sub>d< / com:Sub> is H; in another embodiment, R'<com:Sub>d< / com:Sub> is <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl; in another embodiment, R'<com:Sub>d< / com:Sub> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl.

[00295] R<com:Sub>e< / com:Sub> and R'<com:Sub>e< / com:Sub>

[00296] In one embodiment, <com:Math><semantics>Re<annotation encoding="application / x-tex">R_e< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>Re<annotation encoding="application / x-tex">R_e< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl.

[00297] In one embodiment, R'<com:Sub>e< / com:Sub> is H; in another embodiment, R'<com:Sub>e< / com:Sub> is <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl.

[00298] <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rf′<annotation encoding="application / x-tex">R'_f< / annotation>< / semantics>< / com:Math>

[00299] In one embodiment, <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> is H; in another embodiment, <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl.

[00300] In one embodiment, R'<com:Sub>f< / com:Sub> is H; in another embodiment, R'<com:Sub>f< / com:Sub> is <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl.

[00301] Any of the above technical solutions in any specific embodiment or any combination thereof may be combined with any technical solution or any combination thereof in other specific embodiments. For example, any technical solution of Q, or any combination thereof, may be combined with any technical solution of M<com:Sub>1< / com:Sub>, M<com:Sub>2< / com:Sub>, G<com:Sub>5< / com:Sub>, G<com:Sub>6a< / com:Sub>, G<com:Sub>6b< / com:Sub>, R<com:Sub>9< / com:Sub>, R<com:Sub>10< / com:Sub>, R**, G<com:Sub>1< / com:Sub>, G<com:Sub>2< / com:Sub>, G<com:Sub>3< / com:Sub>, G<com:Sub>4< / com:Sub>, R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub>, R<com:Sub>3< / com:Sub>, R<com:Sub>4< / com:Sub>, R<com:Sub>5< / com:Sub>, R<com:Sub>6< / com:Sub>, R<com:Sub>7< / com:Sub>, R<com:Sub>8< / com:Sub>, R, R", R<com:Sup>s< / com:Sup>, Ar<com:Sub>2< / com:Sub>, L<com:Sub>a< / com:Sub>, L<com:Sub>e< / com:Sub>, L<com:Sub>b< / com:Sub>, L<com:Sub>f< / com:Sub>, L<com:Sub>c< / com:Sub>, L<com:Sub>d< / com:Sub>, R<com:Sub>a< / com:Sub>, R'<com:Sub>a< / com:Sub>, R<com:Sub>b< / com:Sub>, R'<com:Sub>b< / com:Sub>, R<com:Sub>c< / com:Sub>, R'c, Rd, R'd, Re, R'e, Rf and R'f, or any combination thereof. The present disclosure is intended to include all of these combinations of technical solutions and, for reasons of space, will not be listed.

[00302] In a more specific embodiment, the present disclosure provides a compound of formula (IV), or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document]

[00303] wherein,

[00304] M<com:Sub>1< / com:Sub> and M<com:Sub>2< / com:Sub> are independently selected from -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>a< / com:Sub>-, <com:Math><semantics>−NRaC(O)NRa<annotation encoding="application / x-tex">-NR_aC(O)NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)S<annotation encoding="application / x-tex">-OC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRaC(O)O<annotation encoding="application / x-tex">-NR_aC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRa<annotation encoding="application / x-tex">-NR_a< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRa−<annotation encoding="application / x-tex">-C(O)NR_{a-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(O)<annotation encoding="application / x-tex">-NR_{a}C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRaC(O)S<annotation encoding="application / x-tex">-NR_{a}C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)NRa−<annotation encoding="application / x-tex">-SC(O)NR_{a-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)NRa−<annotation encoding="application / x-tex">-OC(S)NR_{a-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRaC(S)O−,−S−S− and −S(O)0−2−;<annotation encoding="application / x-tex">-NR_aC(S)O_{-}, -S_{-}S_{-} \text{ and } -S(O)_{0-2-};< / annotation>< / semantics>< / com:Math>

[00305] Q is selected from a chemical bond, -C(O)O-, -O-, -SC(O)O-, -OC(O)NR<com:Sub>b< / com:Sub>-, <com:Math><semantics>−NRbC(O)NRb<annotation encoding="application / x-tex">-NR_bC(O)NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)S<annotation encoding="application / x-tex">-OC(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)O<annotation encoding="application / x-tex">-OC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)O<annotation encoding="application / x-tex">-NR_bC(O)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(O)<annotation encoding="application / x-tex">-OC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)<annotation encoding="application / x-tex">-SC(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)S<annotation encoding="application / x-tex">-C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRb<annotation encoding="application / x-tex">-NR_b< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NRb−<annotation encoding="application / x-tex">-C(O)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(O)<annotation encoding="application / x-tex">-NR_{b}C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NRbC(O)S<annotation encoding="application / x-tex">-NR_{b}C(O)S< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−SC(O)NRb−<annotation encoding="application / x-tex">-SC(O)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)<annotation encoding="application / x-tex">-OC(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(S)O<annotation encoding="application / x-tex">-C(S)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(S)NRb−<annotation encoding="application / x-tex">-OC(S)NR_{b-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−NRbC(S)O−<annotation encoding="application / x-tex">-NR_bC(S)O_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S−S−<annotation encoding="application / x-tex">-S_{-}S_{-}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−S(O)0−2−<annotation encoding="application / x-tex">-S(O)_{0-2-}< / annotation>< / semantics>< / com:Math>, phenylene and pyridylidene, wherein, the phenylene or pyridylidene is optionally substituted with one or more R*;

[00306] <com:Math><semantics>G5<annotation encoding="application / x-tex">G_5< / annotation>< / semantics>< / com:Math> is a chemical bond or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with one or more R**;

[00307] <com:Math><semantics>G6a<annotation encoding="application / x-tex">G_{6a}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>G6b<annotation encoding="application / x-tex">G_{6b}< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−7<annotation encoding="application / x-tex">C_{1-7}< / annotation>< / semantics>< / com:Math> alkylene, which is optionally substituted with one or more R**;

[00308] G<com:Sub>6a< / com:Sub> and G<com:Sub>6b< / com:Sub> have a total length of 0, 1, 2, 3, 4, 5, 6 or 7 carbon atoms;

[00309] R<com:Sub>9< / com:Sub>, R<com:Sub>10< / com:Sub> and R** are independently H, C<com:Sub>1-8< / com:Sub> alkyl, -L<com:Sub>c< / com:Sub>-OR<com:Sub>c< / com:Sub>, -L<com:Sub>c< / com:Sub>-SR<com:Sub>c< / com:Sub> or -L<com:Sub>c< / com:Sub>-NR<com:Sub>c< / com:Sub>R'<com:Sub>c< / com:Sub>;

[00310] G<com:Sub>1< / com:Sub>, G<com:Sub>2< / com:Sub>, G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> are independently a chemical bond, C<com:Sub>1-13< / com:Sub> alkylene, C<com:Sub>2-13< / com:Sub> alkenylene or <com:Math><semantics>C2−13<annotation encoding="application / x-tex">C_{2-13}< / annotation>< / semantics>< / com:Math> alkynylene, which is optionally substituted with one or more <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math>;

[00311] G<com:Sub>1< / com:Sub> and G<com:Sub>2< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[00312] G<com:Sub>3< / com:Sub> and G<com:Sub>4< / com:Sub> have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms;

[00313] <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R4<annotation encoding="application / x-tex">R_4< / annotation>< / semantics>< / com:Math> are independently H, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl, C<com:Sub>6-10< / com:Sub> aryl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*;

[00314] or, R<com:Sub>3< / com:Sub> and R<com:Sub>4< / com:Sub> are taken together with the N atom to which they are attached to form 3- to 14-membered heterocyclyl, which is optionally substituted with one or more R*;

[00315] or, R<com:Sub>4< / com:Sub> and R<com:Sub>9< / com:Sub> are taken together with the atoms to which they are attached to form 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*;

[00316] R* is independently H, halogen, cyano, C<com:Sub>1-10< / com:Sub> alkyl, C<com:Sub>1-10< / com:Sub> haloalkyl, -L<com:Sub>b< / com:Sub>-OR<com:Sub>b< / com:Sub>, -L<com:Sub>b< / com:Sub>-SR<com:Sub>b< / com:Sub> or -L<com:Sub>b< / com:Sub>-NR<com:Sub>b< / com:Sub>R'<com:Sub>b< / com:Sub>;

[00317] R<com:Sub>5< / com:Sub>, R<com:Sub>6< / com:Sub>, R<com:Sub>7< / com:Sub> and R<com:Sub>8< / com:Sub> are independently C<com:Sub>1-8< / com:Sub> alkyl, which is optionally substituted with one or more R*;

[00318] <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> are independently <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkenyl or <com:Math><semantics>C4−20<annotation encoding="application / x-tex">C_{4-20}< / annotation>< / semantics>< / com:Math> alkynyl, which is optionally substituted with one or more R, and wherein one or more methylene units are optionally and independently replaced with -NR''-;

[00319] <com:Math><semantics>Rs<annotation encoding="application / x-tex">R^s< / annotation>< / semantics>< / com:Math> is independently H, <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-OR<com:Sub>d< / com:Sub>, <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-SR<com:Sub>d< / com:Sub> or <com:Math><semantics>−Ld<annotation encoding="application / x-tex">-L_d< / annotation>< / semantics>< / com:Math>-NR<com:Sub>d< / com:Sub>R'<com:Sub>d< / com:Sub>;

[00320] R is independently H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>a< / com:Sub>-OR<com:Sub>a< / com:Sub>, -L<com:Sub>a< / com:Sub>-SR<com:Sub>a< / com:Sub> or -L<com:Sub>a< / com:Sub>-NR<com:Sub>a< / com:Sub>R'<com:Sub>a< / com:Sub>;

[00321] R'' is independently H or <com:Math><semantics>C1−20<annotation encoding="application / x-tex">C_{1-20}< / annotation>< / semantics>< / com:Math> alkyl;

[00322] La and Le are independently a chemical bond or C<com:Sub>1-20< / com:Sub> alkylene;

[00323] <com:Math><semantics>Lb<annotation encoding="application / x-tex">L_b< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Lf<annotation encoding="application / x-tex">L_f< / annotation>< / semantics>< / com:Math> are independently a chemical bond or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene;

[00324] L<com:Sub>c< / com:Sub> is independently a chemical bond or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene;

[00325] <com:Math><semantics>Ld<annotation encoding="application / x-tex">L_d< / annotation>< / semantics>< / com:Math> is independently a chemical bond or <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkylene;

[00326] R<com:Sub>a< / com:Sub> and R'<com:Sub>a< / com:Sub> are independently selected from H, C<com:Sub>1-20< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-20< / com:Sub> alkyl, -L<com:Sub>e< / com:Sub>-OR<com:Sub>e< / com:Sub>, -L<com:Sub>e< / com:Sub>-SR<com:Sub>e< / com:Sub> and -L<com:Sub>e< / com:Sub>-NR<com:Sub>e< / com:Sub>R'<com:Sub>e< / com:Sub>;

[00327] R<com:Sub>b< / com:Sub> and R'<com:Sub>b< / com:Sub> are independently selected from H, C<com:Sub>1-10< / com:Sub> alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C<com:Sub>1-10< / com:Sub> alkyl, -L<com:Sub>f< / com:Sub>-OR<com:Sub>f< / com:Sub>, -L<com:Sub>f< / com:Sub>-SR<com:Sub>f< / com:Sub> and -L<com:Sub>f< / com:Sub>-NR<com:Sub>f< / com:Sub>R'<com:Sub>f< / com:Sub>;

[00328] <com:Math><semantics>Rc<annotation encoding="application / x-tex">R_c< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rc′<annotation encoding="application / x-tex">R'_c< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl;

[00329] <com:Math><semantics>Rd<annotation encoding="application / x-tex">R_d< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rd′<annotation encoding="application / x-tex">R'_d< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−14<annotation encoding="application / x-tex">C_{1-14}< / annotation>< / semantics>< / com:Math> alkyl;

[00330] R<com:Sub>e< / com:Sub> and R'<com:Sub>e< / com:Sub> are independently H or C<com:Sub>1-20< / com:Sub> alkyl;

[00331] <com:Math><semantics>Rf<annotation encoding="application / x-tex">R_f< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Rf′<annotation encoding="application / x-tex">R'_f< / annotation>< / semantics>< / com:Math> are independently H or <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl.

[00332] In a more specific embodiment, the present disclosure provides a compound of formula (IV) described above, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, M<com:Sub>1< / com:Sub> and M<com:Sub>2< / com:Sub> are independently selected from <com:Math><semantics>−C(O)O−<annotation encoding="application / x-tex">-C(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SC(O)O−<annotation encoding="application / x-tex">-SC(O)O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OC(O)NRa−<annotation encoding="application / x-tex">-...

Claims

1. A compound of formula (IV), or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein, M 1 M_1 and M 2 M_2 are independently -C(O)O-, -OC(O)O-, -OC(O)-, -SC(O)-, -C(O)S-, − C ( O ) N R a -C(O)NR_a -, or − N R a C ( O ) -NR_aC(O) -; Q is − C ( O ) O Q \text{ is } -C(O)O -; G 5 is a chemical bond; G 6 a G_{6a} and G 6 b G_{6b} are independently a chemical bond or C 1 − 7 C_{1-7} alkylene; G 6 a G_{6a} and G 6 b G_{6b} have a total length of 0, 1, 2, 3, 4, 5, 6 or 7 carbon atoms; R 9 R_9 and R 10 R_{10} are independently H or C 1 − 8 C_{1-8} alkyl; G 1 , G 2 , G 3 and G 4 are independently a chemical bond, C 1-13 alkylene, C 2-13 alkenylene or C 2 − 13 C_{2-13} alkynylene, which is optionally substituted with one or more R s R^s ; G 1 and G 2 have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms; G 3 and G 4 have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 carbon atoms; R 3 R_3 and R 4 R_4 are independently H, C 1 − 10 C_{1-10} alkyl, C 1 − 10 C_{1-10} haloalkyl, C 2 − 10 C_{2-10} alkenyl, C 2 − 10 C_{2-10} alkynyl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl, C 6 − 10 C_{6-10} aryl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*: or, R 3 and R 4 are taken together with the N atom to which they are attached to form 3- to 14-membered heterocyclyl, which is optionally substituted with one or more R*; or, R 4 and R 9 are taken together with the atoms to which they are attached to form 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, which is optionally substituted with one or more R*; R * R^* is independently H, halogen, cyano, C 1 − 10 C_{1-10} alkyl, C 1 − 10 C_{1-10} haloalkyl, − L b -L_b -OR b , − L b -L_b -SR b or − L b − N R b R b ′ -L_b-NR_bR'_b ; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; R 1 R_1 and R 2 R_2 are independently C 4 − 20 C_{4-20} alkyl, C 4 − 20 C_{4-20} alkenyl or C 4 − 20 C_{4-20} alkynyl, which is optionally substituted with one or more R, and wherein one or more methylene units are optionally and independently replaced with -NR''-; R s is independently H, C 1-14 alkyl, -L d -OR d , -L d -SR d or -L d -NR d R' d ; R is independently H, C 1-20 alkyl, -L a -OR a , -L a -SR a or -L a -NR a R' a ; R'' is independently H or C 1 − 20 C_{1-20} alkyl; L a L_a and L e L_e are independently achemical bond or C 1 − 20 C_{1-20} alkylene; L b L_b and L f L_f are independently a chemical bond or C 1 − 10 C_{1-10} alkylene; L d L_d is independently a chemical bond or C 1 − 14 C_{1-14} alkylene; R a and R' a are independently H, C 1-20 alkyl, 3- to 14-membered cycloalkyl, and 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C 1-20 alkyl, -L e -OR e , -L e -SR e and -L e -NR e R' e ; R b and R' b are independently H, C 1-10 alkyl, 3- to 14-membered cycloalkyl, or 3- to 14-membered heterocyclyl, which are optionally substituted with one or more of the following substituents: H, C 1-10 alkyl, -L f -OR f , -L f -SR f and -L f -NR f R' f ; R d R_d and R d ′ R'_d are independently H or C 1 − 14 C_{1-14} alkyl; Re and R'e are independently H or C 1-20 alkyl; R f R_f and R f ′ R'_f are independently H or C 1 − 10 C_{1-10} alkyl.

2. The compound of formula (IV) of claim 1, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, M 1 M_1 and M 2 M_2 are independently -C(O)O-, − O C ( O ) -OC(O) -, − S C ( O ) -SC(O) -, or − C ( O ) S -C(O)S -.

3. The compound of formula (IV) of claim 1, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, M 1 M_1 and M 2 M_2 are independently -C(O)O- or − O C ( O ) − . -OC(O)-.

4. The compound of formula (IV) of claim 1, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, which has the structure of formula (V): [Image disponible dans le document PDF, Image available in the PDF document] (V) wherein, Q is − C ( O ) O Q \text{ is } -C(O)O -; G 6 a G_{6a} and G 6 b G_{6b} are independently a chemical bond or C 1 − 5 C_{1-5} alkylene; G 6 a G_{6a} and G 6 b G_{6b} have a total length of 0, 1, 2, 3, 4 or 5 carbon atoms; R 9 R_9 is H or C 1 − 6 C_{1-6} alkyl; one of L 3 and L 5 , or one of L 4 and L 6 is -(CR s R s ') 2 -, -CH=CH-, or -C ≡ \equiv C-, and the other is a chemical bond; G 1a , G 1b , G 2a , G 2b , G 3a , G 3b , G 4a and G 4b are independently a chemical bond or C 1-7 alkylene, which is optionally substituted with 1, 2, 3, 4 or 5 R s ; G 1 a G_{1a} , G 1 b G_{1b} , G 2 a G_{2a} and G 2 b G_{2b} have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms; G 3a , G 3b , G 4a and G 4b have a total length of 1, 2, 3, 4, 5, 6 or 7 carbon atoms; R 3 R_3 and R 4 R_4 are independently H, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*; or, R 3 and R 4 are taken together with the N atom to which they are attached to form 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*; or, R 4 and R 9 are taken together with the atoms to which they are attached to form 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*; R* is independently H, halogen, cyano, C 1-6 alkyl, C 1-6 haloalkyl, -L b -OR b or − L b − N R b R b ′ -L_b-NR_bR'_b ; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O, S or N R a NR_a ; L 1 L_1 and L 2 L_2 are independently -(CRR') 2 -, -CH=CH-, -C=C- or -NR''-; G 7 , G 8 , G 9 and G 10 are independently a chemical bond or C 1-12 alkylene, which is optionally substituted with 1, 2, 3, 4, 5 or 6 R; G 7 G_7 and G 8 G_8 have a total length of 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; G 9 and G 10 have a total length of 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; R s and R s ' are independently H, C 1-10 alkyl, -L d -OR d or -L d -NR d R' d ; R and R' are independently H, C 1-14 alkyl, -L a -OR a or -L a -NR a R' a ; R'' is independently H or C 1 − 14 C_{1-14} alkyl; La is independently a chemical bond or C 1-14 alkylene; L b is independently a chemical bond or C 1-6 alkylene; L d L_d is independently a chemical bond or C 1 − 10 C_{1-10} alkylene; R a and R' a are independently H, C 1-14 alkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl; R b and R' b are independently H, C 1-6 alkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl; R d R_d and R d ′ R'_d are independently H or C 1 − 10 C_{1-10} alkyl.

5. The compound of formula (IV) of claim 1, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, which has the structure of formula (VI) or formula (VII): [Image disponible dans le document PDF, Image available in the PDF document] (VI) [Image disponible dans le document PDF, Image available in the PDF document] or (VII) wherein, a, a', b and g are independently 0, 1, 2, 3, 4 or 5, a' and b are not 0 at the same time; a'+g=0, 1, 2, 3, 4 or 5; c and e are independently 3, 4, 5, 6, 7, 8 or 9; d and f are independently 0, 1, 2, 3 or 4; c+d=3, 4, 5, 6, 7, 8 or 9, e+f=3, 4, 5, 6, 7, 8 or 9; [Image disponible dans le document PDF, Image available in the PDF document] methylenes in are optionally and independently substituted with 1, 2, 3, 4 or 5 C 1 − 6 C_{1-6} alkyl; R 3 R_3 and R 4 R_4 are independently H, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*; or, R 3 and R 4 are taken together with the N atom to which they are attached to form 3- to 10-membered heterocyclyl, which is optionally substituted with 1, 2, 3, 4 or 5 R*; R * R^* is independently H, halogen, cyano, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, − L b -L_b -OR b or − L b − N R b R b ′ -L_b-NR_bR'_b ; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 and Y 2 are independently O, S or NR a ; L 1 L_1 and L 2 L_2 are independently -(CRR') 2 -, -CH=CH-, -C=C- or -NR''-; G 7 G_7 , G 8 G_8 , G 9 G_9 and G 10 G_{10} are independently a chemical bond or C 1 − 12 C_{1-12} alkylene, which is optionally substituted with 1, 2, 3, 4, 5 or 6 R; G 7 and G 8 have a total length of 6, 7, 8, 9, 10, 11 or 12 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 6, 7, 8, 9, 10, 11 or 12 carbon atoms; R and R' are independently H, C 1-14 alkyl, -L a -OR a or -L a -NR a R' a ; L a L_a is independently a chemical bond or C 1 − 14 C_{1-14} alkylene; L b is independently a chemical bond or C 1-6 alkylene; R a R_a and R a ′ R'_a are independently H, C 1 − 14 C_{1-14} alkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl; R b and R' b are independently H, C 1-6 alkyl, 3- to 10-membered cycloalkyl or 3- to 10-membered heterocyclyl; R" is independently H or C 1 − 14 C_{1-14} alkyl.

6. The compound of formula (VI) or formula (VII) of claim 5, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 0, 1, 2, 3 or 4; a' and b are independently 0, 1, 2, 3 or 4; g is 0, 1 or 2; a'+g=0, 1, 2, 3, 4 or 5; c and e are independently 3, 4, 5 or 6; d and f are independently 0, 1 or 2; c + d = 4 c+d=4 , 5 or 6, e + f = 4 e+f=4 , 5 or 6; [Image disponible dans le document PDF, Image available in the PDF document] methylenes in are optionally and independently substituted with 1, 2, 3, 4 or 5 C 1 − 6 C_{1-6} alkyl; [Image disponible dans le document PDF, Image available in the PDF document] methylenes in are optionally and independently substituted with 1 or 2 C 1-6 alkyl; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl, which is optionally substituted with 1, 2 or 3 R * R^* ; R * R^* is independently H, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl or − O R b -OR_b ; or, R 3 and R 4 are taken together with the N atom to which they are attached to form 3- to 7-membered heterocyclyl, which is optionally substituted with 1, 2 or 3 R*; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O, S or N R a NR_a ; L 1 L_1 and L 2 L_2 are independently -(CHR) 2 -, -CH=CH-, -C=C- or -NR''-; G 7 G_7 and G 9 G_9 are independently a chemical bond or C 1 − 6 C_{1-6} alkylene; G 8 G_8 and G 10 G_{10} are independently C 1 − 10 C_{1-10} alkylene; G 7 and G 8 have a total length of 6, 7, 8, 9 or 10 carbon atoms; G 9 and G 10 have a total length of 6, 7, 8, 9 or 10 carbon atoms; 1, 2 or 3 methylenes in G 7 G_7 , G 8 G_8 , G 9 G_9 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 1 − 8 C_{1-8} alkyl; R" is independently H or C 1 − 10 C_{1-10} alkyl; R a R_a is independently H or C 1 − 10 C_{1-10} alkyl; R b R_b is independently H or C 1 − 6 C_{1-6} alkyl.

7. The compound of formula (VI) of claim 6, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 0, 1, 2, 3 or 4; c and e are independently 3, 4, 5 or 6; d and f are independently 0, 1 or 2; c+d=4, 5 or 6, e+f=4, 5 or 6; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl; or, R 3 and R 4 are taken together with the N atom to which they are attached to form 4- to 6-membered heterocyclyl, which is optionally substituted with 1, 2 or 3 R*; R* is independently H, C 1 − 6 C_{1-6} alkyl or C 1 − 6 C_{1-6} haloalkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O, S or N R a NR_a ; L 1 L_1 and L 2 L_2 are independently -(CHR) 2 -, -CH=CH-, -C=C- or -NR''-; G 7 and G 9 are independently a chemical bond or C 1-5 alkylene; G 8 G_8 and G 10 G_{10} are independently C 1 − 8 C_{1-8} alkylene; G 7 and G 8 have a total length of 6, 7, 8, 9 or 10 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 6, 7, 8, 9 or 10 carbon atoms; 1, 2 or 3 methylenes in G 7 G_7 , G 8 G_8 , G 9 G_9 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 1 − 8 C_{1-8} alkyl; R" is independently H or C 7-9 alkyl; R a R_a is independently H or C 8 − 10 C_{8-10} alkyl.

8. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2, 3 or 4; c and e are independently 3, 4, 5 or 6; d and f are independently 0, 1 or 2; c + d = 4 c+d=4 , 5 or 6, e + f = 4 e+f=4 , 5 or 6; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O or S; L 1 L_1 and L 2 L_2 are independently -(CHR) 2 -, -CH=CH- or -C=C-; G 7 G_7 and G 9 G_9 are independently C 1 − 4 C_{1-4} alkylene; G 8 G_8 and G 10 G_{10} are independently C 2 − 7 C_{2-7} alkylene; G 7 and G 8 have a total length of 6, 7 or 8 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 6, 7 or 8 carbon atoms; 1, 2 or 3 methylenes in G 7 G_7 , G 8 G_8 , G 9 G_9 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 1 − 7 C_{1-7} alkyl; provided that, when L 1 L_1 is − C ≡ C − -C \equiv C_- , then G 7 G_7 is C 1 − 2 C_{1-2} alkylene, or when L 2 L_2 is − C ≡ C − -C \equiv C_- , then G 9 G_9 is C 1 − 2 C_{1-2} alkylene.

9. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2, 3 or 4; c and e are independently 4, 5 or 6; d and f are 0; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are O; L 1 L_1 and L 2 L_2 are independently -(CHR) 2 - or -CH=CH-; G 7 and G 9 are independently -CH 2 - or -CH 2 CHR-; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 6 - or -(CH 2 ) 7 -; G 7 and G 8 have a total length of 7 or 8 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 7 or 8 carbon atoms; 1, 2 or 3 methylenes in G 8 G_8 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 4 − 6 C_{4-6} alkyl.

10. The compound of formula (VI) of claim 9, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2, or 3.

11. The compound of formula (VI) of claim 9, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, -G 7 -L 1 -G 8 -H and -G 9 -L 2 -G 10 -H are not − ( C H 2 ) 9 C H 3 -(CH2)9CH3 at the same time.

12. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2; c and e are independently 4, 5 or 6; d and f are 0; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 and Y 2 are independently O or S; one of L 1 L_1 and L 2 L_2 is − C ≡ C -C \equiv C -, the other is − ( C H R ) 2 -(CHR)_2 -, or both of L 1 L_1 and L 2 L_2 are − C ≡ C -C \equiv C -; G 7 and G 9 are -CH 2 -; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 6 - or -(CH 2 ) 7 -; 1 methylene in G 8 G_8 or G 10 G_{10} is optionally and independently substituted with 1 R; R is independently H or C 4-6 alkyl; provided that, only one of the -G 7 -L 1 -G 8 -H and -G 9 -L 2 -G 10 -H is substituted with one non-hydrogen R substituent and the other is unsubstituted.

13. The compound of formula (VI) of claim 12, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, one of L 1 L_1 and L 2 L_2 is − C ≡ C 1 -C \equiv C_1 , the other is − ( C H R ) 2 -(CHR)_2 -.

14. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof,, wherein, a is 2; c and e are independently 4, 5 or 6; d and f are 0; R 3 R_3 and R 4 R_4 are independently C 1 − 3 C_{1-3} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O or S; both of L 1 L_1 and L 2 L_2 are -C ≡ \equiv C-; G 7 and G 9 are -CH 2 -; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 6 - or -(CH 2 ) 7 -.

15. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2; c and e are 3; d and f are 2; R 3 R_3 and R 4 R_4 are independently C 1 − 3 C_{1-3} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are independently O or S; L 1 L_1 and L 2 L_2 are -(CHR) 2 -; G 7 and G 9 are independently -CH 2 - or -CH 2 CHR-; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 5 -, -(CH 2 ) 6 - or -(CH 2 ) 7 -; G 7 and G 8 have a total length of 6, 7 or 8 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 6, 7 or 8 carbon atoms; 1, 2 or 3 methylenes in G 8 G_8 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 1 − 7 C_{1-7} alkyl.

16. The compound of formula (VI) of claim 15, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, R is independently H or C 1-6 alkyl.

17. The compound of formula (VI) of claim 15, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, R is Me.

18. The compound of formula (VI) of claim 7, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a is 2; c and e are 4, 5, or 6; d and f are 0; R 3 R_3 and R 4 R_4 are independently C 1 − 6 C_{1-6} alkyl; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 Y_1 and Y 2 Y_2 are S S ; L 1 L_1 and L 2 L_2 are -(CHR) 2 -; G 7 and G 9 are independently -CH 2 - or -CH 2 CHR-; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 5 -, -(CH 2 ) 6 - or -(CH 2 ) 7 -; G 7 and G 8 have a total length of 7 or 8 carbon atoms; G 9 G_9 and G 10 G_{10} have a total length of 7 or 8 carbon atoms; 1, 2 or 3 methylenes in G 8 G_8 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 4 − 6 C_{4-6} alkyl.

19. The compound of formula (VI) of claim 18, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, G 7 and G 8 have a total length of 8 carbon atoms.

20. The compound of formula (VI) of claim 18, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, G 9 and G 10 have a total length of 8 carbon atoms.

21. The compound of formula (VII) of claim 6, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, a' and b are 2; g is 0 or 1; c and e are 5; d and f are 0; R 3 R_3 is C 1 − 6 C_{1-6} alkyl, which is optionally substituted with 1, 2 or 3 R * R^* ; R * R^* is independently H, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl or − O R b -OR_b ; R 5 R_5 , R 6 R_6 , R 7 R_7 and R 8 R_8 are independently C 1 − 2 C_{1-2} alkyl; Y 1 and Y 2 are independently O or S; L 1 L_1 and L 2 L_2 are -(CHR) 2 -; G 7 and G 9 are independently -CH 2 - or -CH 2 CHR-; G 8 G_8 and G 10 G_{10} are independently -(CH 2 ) 5 -, -(CH 2 ) 6 - or -(CH 2 ) 7 -; G 7 and G 8 have a total length of 6, 7 or 8 carbon atoms; G 9 and G 10 have a total length of 6, 7 or 8 carbon atoms; 1, 2 or 3 methylenes in G 8 G_8 or G 10 G_{10} are optionally and independently substituted with 1 R; R is independently H or C 4-6 alkyl; R b R_b is independently H or C 1 − 6 C_{1-6} alkyl.

22. A compound, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, wherein, the compound is: [Image disponible dans le document PDF, Image available in the PDF document] × \times 0 ∧ \wedge ∧ \wedge ∧ \wedge [Image disponible dans le document PDF, Image available in the PDF document] <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{c} \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \begin{array}{c} \begin{array}{c} \\ \\ \\ \\ \end{array} \end{array} / \______ <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc S S s <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{c} \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ \\ $ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc 44 -------------------------------------- <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{c} \begin{array}{c} \begin{array}{c} \\ \\ \\ \end{array} \end{array} 74 -N------------------------------------ N → 0 N \longrightarrow 0 80 0 <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc N 93 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 $ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\ [Image disponible dans le document PDF, Image available in the PDF document] or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof.

23. A pharmaceutical composition, comprising the compound of any one of claims 1-22, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, and pharmaceutically acceptable excipient(s).

24. The compound of any one of claims 1-22, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, or the pharmaceutical composition of claim 23, for use in delivering a load; wherein, the load is one or more of therapeutic, prophylactic or diagnostic agents.

25. Use of the compound of any one of claims 1-22, or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof, or the pharmaceutical composition of claim 23, in the manufacture of a medicament for delivering a load; wherein, the load is one or more of therapeutic, prophylactic or diagnostic agents.

26. A method for preparing the compound of general formula (II), comprising: [Image disponible dans le document PDF, Image available in the PDF document] reacting the compound of general formula (IIb) with the compound of general formula (IIc), to give the compound of general formula (II); wherein, R 1 R_1 , R 2 R_2 , G 1 G_1 , G 2 G_2 , G 3 G_3 , and G 4 G_4 are as defined in claim 1; G 6 G_6 is C 1 − 8 C_{1-8} alkyl; M 1 M_1 and M 2 M_2 are as defined in any one of claims 1-3; R 3 and R 4 are as defined in any one of claims 1, 4-9, 12, 14-15 and 18; R 5 , R 6 , R 7 and R 8 are as defined in claim 1.

27. A method of preparing the compound of general formula (II'), comprising: [Image disponible dans le document PDF, Image available in the PDF document] reacting the compound of general formula (II'a) with the compound of general formula (II'b), to give the compound of general formula (II'); wherein, R 1 R_1 , R 2 R_2 , G 1 G_1 , G 2 G_2 , G 3 G_3 , G 4 G_4 and G 5 G_5 are as defined in claim 1; G 6 G_6 is C 1 − 8 C_{1-8} alkyl; M 1 M_1 and M 2 M_2 are as defined in any one of claims 1-3; R' 3 , R' 4 , R' 5 and R' 6 are each independently C 1-2 alkyl; R' 7 is H, halogen, cyano, OH, C 1-6 alkyl, C 1-6 alkoxy, -NH 2 , -NHC 1-6 alkyl or -N(C 1-6 alkyl) 2 .