Terpyridine diketone compound or salt thereof, preparation method therefor and application thereof

Abstract

The present invention relates to a compound represented by general formula (I) in the field of chemical medicine technology, a racemate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof, as a p38 / MK2 inhibitor, capable of inhibiting production of cytokine TNFα, and used to treat diseases such as arthritis. [Image available in the PDF document]

Description

TERPYRIDINE DIKETONE COMPOUND OR SALT THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF TECHNICAL FIELD The present invention belongs to the technical field of chemical drugs, and relates to a terpyridine diketone compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. BACKGROUND Mitogen-Activated Protein Kinase (MAPK) is a conserved family of enzymes that use a phosphorylation cascade to transmit and deliver external stimuli to produce a coordinated cellular response to the environment. The MAPK is a proline-induced serine / threonine-specific protein kinase that regulates cellular activities such as gene expression, mitosis, differentiation and cell survival / apoptosis. Up to now, mammal MAPKs of four different categories have been identified, which are extracellular signal transduction kinase (ERK1 and ERK2), c-jun N-terminal kinase-1 (JNK1-3), p38MAPK (p38<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, p38<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>, p38<semantics>γ<annotation encoding="application / x-tex">\gamma< / annotation>< / semantics>, and p38<semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics>), and ERK5. Scientific exploration of such pathway from biological, cellular, and in vivo perspectives is primarily implemented by the availability of a good-performance, selective small-molecule inhibitor of the p38MAPK. The small-molecule inhibitor targets an <semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics> subtype of the p38MAPK and targets <semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics> subtype to a lesser extent. The p38<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>MAPK is a main subtype participating immune reaction and inflammatory response. Therefore, functions of the p38MAPK are critical to the generation and activities of various pro-inflammatory cytokines in cells such as macrophages, monocytes, synoviocytes and endothelial cells. The pro-inflammatory cytokines include TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, IL-1, IL-6, and IL-8. The p38MAPK is also responsible for inducing key inflammatory enzymes, such as COX2 and iNOS, which respectively are main resources of eicosanoid and nitric oxide at sites of inflammation. In addition, the p38MAPK pathway regulates the expression of matrix metalloproteinase (MMP). The MMP includes MMP2, MMP9, and MMP13. The use of selective and effective inhibitors has facilitated the discovery of a plurality of families of p38MAPK substrates. The p38MAPK substrates include transcription factors, MAPKAP kinases and other enzymes. The MAPKAP kinases (MK2, MK-3, and PRAK) are selectively phosphorylated by the p38MAPK, and the phosphorylation of MSK1 / 2, MNK1 / 2, and RSKb is catalyzed by the p38MAPK and ERK. Although the identification of the substrates is difficult due to the absence of specific inhibitors, it is thought that activation of the RSKb plays a role in cell survival. Once being phosphorylated and activated by the p38MAPK, the MK-2, the MK-3, and the PRAK share similar substrate specificities. All of these kinases can phosphorylate small heat shock proteins Hsp27. Studies have shown that PRAK- and MK3-deficient mice do not show any tolerance to endotoxic shock or lipopolysaccharide (LPS)-induced reduction in cytokine production. In contrast, MK-2-deficient mice show a resistance to endotoxic shock and an impaired inflammatory response, as well as a significantly decreased production of cytokines such as TNFα, IFNy and IL-6. Thus, the p38 / MK2 axis specifically is necessary and sufficient for mediating pro-inflammatory responses. By means of p38:MK2 interaction and by using the MK2 as a p38 substrate, a new p38α inhibitor showing properties of interest is discovered (Davidson et al.). The inhibitor shows substrate selectivity by preventing p38α-dependent phosphorylation of MK2 (Ki app 300nM) and simultaneously retaining p38α-dependent phosphorylation of ATF2 (Ki app>20uM). Compared with a conventional p38ATP competitive inhibitor that blocks the p38-dependent phosphorylation of all of the p38 substrates, the new inhibitor is unique in function. A second independent research also describes the p38 inhibitor having unique mechanism performance. The work shows new mechanisms of selectively inhibiting the p38-dependent phosphorylation of the MK2. Different from the previous researches by Davidson et al., unique compounds of these mechanisms compete with the ATP and stabilize p38 / MK2 compounds. To sum up, the two researches clearly prove such a concept that p38 / MK2 axis block may be selectively implemented by using small molecule inhibitors. Compared with the conventional p38MAPK inhibitors, these p38 / MK2 inhibitors should retain or improve efficiency and show improved safety features in animal models of disease or in human body clinical environments. SUMMARY In view of problems in the prior art, this application provides a compound, as a p38 / MK2 inhibitor. The compound may inhibit the production of cytokine TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, so as to regulate related diseases such as inflammatory response. According to a first aspect, this application provides a compound shown in a general formula (I), or a racemate, an isomer, or a pharmaceutically acceptable salt thereof: [Image disponible dans le document PDF, Image available in the PDF document] According to a second aspect, the present invention further provides a pharmaceutical composition. The pharmaceutical composition includes any of the therapeutically effective amount of the compound described above or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. According to a third aspect, the present invention further provides an application of the therapeutically effective amount of the compound described above or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating medical conditions. The disease is a p38 / MK2 related disease. The compound may inhibit the production of cytokine TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, so as to regulate related diseases such as inflammatory response. Specifically, the medical conditions are selected from chronic inflammatory disease, acute inflammatory disease, or self-inflammatory disease. Specifically, the present invention is achieved by the following technical solutions. A compound shown in a general formula (I), or a racemate, or an isomer, or a pharmaceutically acceptable salt thereof is provided. [Image disponible dans le document PDF, Image available in the PDF document] (l) R1 and R1 are independently selected from hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, alkyl heterocycloalkyl, phenyl, heteroaryl, haloalkyl, or cyano, or R1 and R1' are cyclized to the cycloalkyl or the heterocycloalkyl together. R2 is selected from hydrogen, halogen, hydroxyl, cyano, alkyl, alkoxy, alkoxyalkyl, or haloalkyl. R3 is independently selected from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, halogen, alkoxy, cyano, haloalkoxy, or sulfonyl. m is 0, 1, 2, or 3. R4 is selected from hydrogen, alkyl, cycloalkyl, alkoxy, or haloalkyl. R5 is selected from hydrogen, alkyl, cycloalkyl, alkoxy, or haloalkyl. R6 is selected from hydrogen, halogen, cyano, alkyl, cycloalkyl, or haloalkyl. ring A is selected from an aromatic ring or a heteroaromatic ring. R7 is independently selected from hydrogen, halogen, cyano, alkyl, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, or sulfonyl. n is 0, 1, 2, 3, 4, or 5. <semantics>X<annotation encoding="application / x-tex">X< / annotation>< / semantics> is <semantics>O<annotation encoding="application / x-tex">O< / annotation>< / semantics>, <semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics> or <semantics>NH<annotation encoding="application / x-tex">NH< / annotation>< / semantics>. R8 and R9 are independently selected from hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, or haloalkyl, or R8 and R9 are cyclized to the cycloalkyl or the heterocycloalkyl together. As a preferred technical solution of the present invention, the alkyl is selected from <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkyl, and the <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkyl is selected from methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, sec-pentyl, 1-ethylpropyl, 2-methylbutyl, tert-pentyl, 1,2-dimethylpropyl, isopentyl, neopentyl, n-hexyl, isohexyl, sec-hexyl, tert-hexyl, neohexyl, 2-methylpentyl, 1,2-dimethylbutyl, or 1-ethylbutyl. Alkoxy is selected from <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkoxy, and the <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkoxy is selected from methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentyloxy, sec-pentyloxy, 1-ethylpropoxy, 2-methylbutoxy, tert-pentyloxy, 1,2-dimethylpropoxy, isopentyloxy, neopentyloxy, n-hexyloxy, isohexyloxy, sec-hexyloxy, tert-hexyloxy, neohexyloxy, 2-methylpentyloxy, 1,2-dimethylbutoxy, or 1-ethylbutoxy. Alkoxyalkyl is selected from <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>alkoxy-<semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>alkyl, and the <semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>alkoxy-<semantics>C1−4<annotation encoding="application / x-tex">C_{1-4}< / annotation>< / semantics>alkyl is further selected from methoxymethyl, methoxyethyl, methoxypropyl, methoxybutyl, ethoxymethyl, ethoxyethyl, ethoxypropyl, ethoxybutyl, propoxymethyl, propoxyethyl, propoxypropyl, propoxybutyl, butoxymethyl, butoxyethyl, butoxypropyl, or butoxybutyl. As a preferred technical solution of the present invention, the cycloalkyl is selected from cycloalkyl of <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>, and the cycloalkyl of <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> is selected from cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl. As a preferred technical solution of the present invention, the aromatic ring is selected from a four-membered ring, a fused ring containing the four-membered ring, a five-membered ring, a fused ring containing the five-membered ring, a six-membered ring, a fused ring containing the six-membered ring, a biphenyl type aromatic ring. The heteroaromatic ring means that one or more carbon atoms on the aromatic ring are substituted by a heteroatom. The aromatic ring includes a benzene ring and a naphthalene ring. The heteroaromatic ring includes indazole, quinoline, isoquinoline, quinoxaline, indole, isoindole, cinnoline, quinazoline, phthalazine, purine, naphthyridine, pteridine, benzofuran, benzothiophene, benzoxazole, benzothiazole, benzisoxazole, benzisothiazole, benzoxadiazole, benzothiadiazole, benzotriazole, benzotriazine, benzimidazole, pyrazinopyrazole, pyrazinopyrimidine, pyrazinopyridazine, pyrazinotriazine, pyrimidopyrazole, pyrimidazole, pyrimidotriazole, pyrimidotriazine, pyrimidopyridazine, pyridazinoimidazole, pyridazinopyrazole, pyridazinotriazole, pyridazinotriazine, triazinoimidazole, triazinopyrazole, triazinotriazole, pyridooxazole, pyridothiazole, pyridoisoxazole, pyridoisothiazole, pyridooxadiazole, pyridothiadiazole, pyridofuran, pyridopyrrole, pyrazinooxazole, pyrazinothiazole, pyrazinoisoxazole, pyrazinoisothiazole, pyrazinooxadiazole, pyrazinothiadiazole, pyrazinofuran, pyrazinopyrrole, pyrimidooxazole, pyrimidothiazole, pyrimidoisoxazole, pyrimidoisothiazole, pyrimidooxadiazole, pyrimidothiadiazole, pyrimidofuran, pyrimidopyrrole, pyridazinooxazole, pyridazinothiazole, pyridazinoisoxazole, pyridazinoisothiazole, pyridazinooxadiazole, pyridazinothiadiazole, pyridazinofuran, pyridazinopyrrole, triazinooxazole, triazinothiazole, triazinoisoxazole, triazinoisothiazole, triazinooxadiazole, triazinothiadiazole, triazinofuran, and triazinopyrrole. Specifically, for example, the naphthidine is selected from NNN, NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Nor Nor Nor Nor Nor Nor Nor Nor Nor Nor HN HN N Or HN N Or N N Or N N Or N N N Or N N N Or N N N OR N N N N OR N N N N N N N N N N The pyrazinotriazole is selected from <semantics>N=N=N=N=N=N=N=N=N=N<annotation encoding="application / x-tex">N = N = N = N = N = N = N = N = N = N< / annotation>< / semantics> pyrimidopyrazole is selected from N-N or N-N . The pyrimidoimidazole is selected from N or N N N N N N N N N N N N N N N N N <semantics>N=N=N<annotation encoding="application / x-tex">N = N = N< / annotation>< / semantics>. The pyridazinoimidazole is selected from or <semantics>N=N=N=N<annotation encoding="application / x-tex">N = N = N = N< / annotation>< / semantics> The N or N N . The triazinoimidazole is selected pyridazinotriazole is selected from from N, N, N, or N, N. The pyridopyridazine is selected from N, N, N N, N, N, or N, or N, The pyridopyrazole is selected from or . The pyridopyrimidine is selected from , N, or <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>. The pyridotriazine is selected from <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, <semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>, N, or N, or N, N, N, N, N, N, N, N, N, N, N, N, N, Specifically, for example, the heterocyclic alkyl is selected from <semantics>□<annotation encoding="application / x-tex">\Box< / annotation>< / semantics>, <semantics>□<annotation encoding="application / x-tex">\Box< / annotation>< / semantics>, <semantics>⟨0⟩⟨N⟩<annotation encoding="application / x-tex">\langle 0 \rangle \langle N \rangle< / annotation>< / semantics> и _ Н [Image disponible dans le document PDF, Image available in the PDF document] As a preferred technical solution of the present invention, the halogen is selected from fluorine, chlorine, bromine, or iodine. The haloalkyl means that one or more hydrogen atoms on the alkyl aresubstituted by the halogen. The haloalkoxy means that one or more hydrogen atoms on the alkoxy are substituted by the halogen. The heterocycloalkyl means that one or more carbon atoms on the cycloalkyl aresubstituted byaaheteroatom. The alkylcycloalkylmeans that one or more hydrogen atoms on the cycloalkyl are substituted by an alkyl, and the alkylheterocycloalkylmeans that one or more hydrogen atoms on the heterocycloalkyl are substituted by an alky. As a preferred technical solution of the present invention, a heteroatom is selected from nitrogen, oxygen, or sulfur, and there are one or more heteroatoms. As a preferred technical solution of the present invention, the ring A is selected from [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , , , , , , , , , , , , , , , , , , , As a preferred technical solution of the present invention, the compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof has a structure of a formula (Ia), a formula (Ib), a formula (Ic), a formula (Id), a formula (Ie), a formula (If), or a formula (Ig). [Image disponible dans le document PDF, Image available in the PDF document] Wherein, m is 0, 1, 2, or 3; n is 0, 1, 2, 3, 4, or 5; and R1, R1, R2, R3, R4, R5, R6, R7, R8, and <semantics>R9<annotation encoding="application / x-tex">R^9< / annotation>< / semantics> are defined as above. As a preferred technical solution of the present invention, m is 0 or 1; and n is 0, 1, or 2. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The ring A is selected from . . . . . . . . . . . . . . . . . . . or [Image disponible dans le document PDF, Image available in the PDF document] . R1 and R1 are selected from hydrogen, methyl, or ethyl, and R1 and R1 are cyclized to [Image disponible dans le document PDF, Image available in the PDF document] R2 is selected from hydrogen, hydroxyl, difluoromethyl, or cyano. R3 is selected from hydrogen, methyl, methoxy, chlorine, or bromine. R4 is selected from methyl, cyclopropyl, methoxy, ethyl, fluoromethyl, or trifluoromethyl. R5 is selected from methyl. R6 is selected from chlorine, hydrogen, or bromine. R7 is selected from hydrogen, fluorine, chlorine, bromine, cyclopropyl, methoxy, cyano, methyl, or trifluoromethyl. R8 and R9 are hydrogen. As a preferred technical solution of the present invention, the compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof is selected from the following. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] As a preferred technical solution of the present invention, the pharmaceutically acceptable salt refers to a salt prepared by the compound, or a racemate or an isomer thereof, and a pharmaceutically acceptable acid or base. As a preferred technical solution of the present invention, more than one hydrogen atom of the compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof is substituted by isotope deuterium. The present invention further provides a pharmaceutical composition. The pharmaceutical composition includes the therapeutically effective amount of the compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The present invention further provides an application of the compound, or a racemate, an isomer, or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases. The diseases are p38 / MK2 related diseases and specifically selected from a chronic inflammatory disease and an acute inflammatory disease. Preferably, the chronic inflammatory disease is rheumatoid arthritis. Compared with compounds in the prior art, the compound of the present invention has improved TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics> activity, solubility, and in vivo PK effects. For clarity, generic terms used in the description of compound are defined herein. Unless otherwise specified, the following terms and phrases used herein are intended to have the following meanings. A specific term or phrase should not be considered indeterminate or unclear without specific definitions, but should be understood in its ordinary meaning. When a trade name appears herein, the trade name is intended to refer to a corresponding commodity or an active ingredient. As used herein, the term "pharmaceutically acceptable" aims at compounds, materials, compositions and / or dosage forms which, within the scope of sound medical judgment, are suitable for use in contact with human and animal tissue without excessive toxicity, irritation, allergic reactions or other problems or complications, and is commensurate with a reasonable benefit / risk ratio. The term "pharmaceutically acceptable salt" is a salt of the compound of the present invention, and is prepared from the compound of the present invention having a specified substituent and a pharmaceutically acceptable acid or base. In addition to the form of salt, the compound provided in the present invention also has a form of prodrug. The prodrug of the compound described herein is readily chemically changed under physiological conditions, so as to be converted to the compound of the present invention. in addition, the prodrug may be chemically or biochemically converted to the compound of the present invention in an in vivo environment. Certain compounds of the present invention may exist in non-solvated or solvated forms, including hydrate forms. Generally, the solvated forms and the non-solvated forms are equivalent and are intended to be included within the scope of the present invention. The compound of the present invention may exist in a specific geometric or stereoisomeric form. All of such compounds assumed in the present invention include cis and trans isomers, (-)- and (+)-enantiomers, (R)- and (S)-enantiomers, diastereomers isomers, (D)-isomers, (L)-isomers, atropisomers, and racemic mixtures thereof and other mixtures. The mixtures are, for example, mixtures enriched by the enantiomers or diastereomers. All of these mixtures are within the scope of the present invention. Substituents such as alkyl may have additional asymmetric carbon atoms. All of these isomers and mixtures thereof are included within the scope of the present invention. Optically active (R)- and (S)-isomers, as well as D and L isomers, atropisomers, and the like, may be prepared by chiral synthesis or chiral reagents or other conventional technologies. An enantiomer of a certain compound in the present invention may be prepared by asymmetric synthesis or derivatization with chiral auxiliaries. The obtained diastereomeric mixtures are separated, and an auxiliary group is cleaved to provide the pure required enantiomer. Alternatively, when a molecule contains a basic functional group (such as amino) or an acidic functional group (such as carboxyl), a diastereomeric salt is formed with appropriate optically active acids or bases. Then, the diastereoisomers are split by means of conventional methods known in the art, and the pure enantiomers are recycled. In addition, the separation of the enantiomers and the diastereoisomers is generally completed by using chromatography. The chromatography adopts a chiral stationary phase, and is optionally combined with chemical derivatization (for example, generating carbamate from amines). Atoms of the compound molecule of the present invention are isotopes, and effects of prolonging half-life, reducing a clearance rate, stabilizing metabolism and improving in vivo activities may be generally achieved through isotope derivatization. In addition, an implementation solution is included. At least one atom is substituted by an atom with a same atomic number (number of protons) and different mass numbers (sum of protons and neutrons). Examples of the isotopes included in the compound of the present invention include hydrogen atoms, carbon atoms, nitrogen atoms, oxygen atoms, phosphorus atoms, sulfur atoms, fluorine atoms, and chlorine atoms, which respectively include 2H, 3H, 13C, 14C, 15N, 17O, 18O, 31P, 32P, 35S, 18F, 36Cl. In particular, radioisotopes that emit radiation with the decaying of the radioisotopes decay, such as 3H or 14C, may be used in the topographic anatomy examination of pharmaceutical preparations or in vivo compounds. Stable isotopes neither decaynor change with the amount of isotopes nor are the isotopes radioactive, so the isotopes are safe to use. When the atoms constituting the compound molecule of the present invention are isotopes, the isotopes can be converted according to general methods by substituting a reagent used in synthesis with a reagent containing the corresponding isotopes. The compound of the present invention may include unnatural proportions of atomic isotopes at one or more atoms that constitute the compound. For example, the compound may be labeled with the radioisotopes, such as deuterium (2H), iodine-125 (125 I) or C-14 (14C). The transformations of all of the isotopic compositions of the compound of the present invention, whether radioactive or not, are included within the scope of the present invention. Further, one or more hydrogen atoms of the compound of the present invention are substituted with the isotope deuterium (2H). After deuterization, the compound of the present invention has the effects of prolonging the half-life, reducing the clearance rate, stabilizing the metabolism and improving the in vivo activity. A method for preparing the isotopic derivatives generally includes a phase-transfer catalysis method. For example, a preferred deuterization method adopts the phase-transfer catalysis method (for example, tetraalkylammonium salt or NBu4HSO4). The methylene protons of a diphenylmethane compound are exchanged by using a phase-transfer catalyst, resulting in higher deuterium introduced through reduction with sodium deuterated borate than with deuterated silane (such as triethyldeuteratedsilane) or lewis acid such as aluminium chloride in the presence of an acid (such as methanesulfonic acid). The term "pharmaceutically acceptable carrier" refers to any preparation carrier or medium that can deliver an effective amount of the active substance of the present invention without interfering with the biological activity of the active substance, and have no toxic side effects to hosts or patients. Representative carriers include water, oil, vegetables, minerals, cream base, lotion base, ointment base, and the like. These bases include suspending agents, thickening agents, penetration enhancers, and the like. Preparations of the bases are well known to those skilled in the field of cosmetics or regional medicines. The term "excipient" generally refers to a carrier, diluent and / or medium required to prepare an effective pharmaceutical composition. The term "effective amount" or "therapeutically effective amount" with respect to a drug or pharmacologically active agent refers to a nontoxic but sufficient amount of the drug or agent to achieve desired effects. For oral dosage forms in the present invention, an "effective amount" of one active substance in a composition refers to the amount required to achieve the desired effect when the active substance is used in combination with another active substance in the composition. The determination of the effective amount varies from person to person, which depends on the age and general condition of a recipient and also depends on the specific active substance. The appropriate effective amount in individual cases may be determined by those skilled in the art based on routine experiments. The term "active ingredient", "therapeutic agent", "active substance" or "active agent" refers to a chemical entity that is effective in treating target disorder, diseases or conditions. The term "optional" or "optionally" means that the subsequently described event or condition may, but are not necessary to occur, and the description includes situations that the event or condition occurs and situations that the event or condition does not occur. " " indicates a linker bond. The compound of the present invention may be prepared by various synthetic methods well known to those skilled in the art, including specific implementations enumerated below, implementations formed in combination with other chemical synthesis methods, and equivalent replacement methods well known to those skilled in the art, and preferred implementations include, but are not limited to, the embodiments of the present invention. BRIEF DESCRIPTION OF DRAWINGS FIG.1 is a schematic representation of the crystal structure of a single molecule of Compound 1A. FIG.2 is the crystal parameters of the crystal structure of Compound 1A. FIG.3 is the atomic coordinates and isotropic displacement parameters of the crystal structure of Compound 1A. FIG.4 is the bond lengths in the crystal structure of Compound 1A. FIG.5 is the bond angles in the crystal structure of Compound 1A. FIG.6 is the dihedral angles in the crystal structure of Compound 1A. DETAILED DESCRIPTION OF THE EMBODIMENTS This application is further described in detail below with reference to embodiments, but implementations of this application are not limited thereto. Embodiment 1 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 1 is shown as follows. At step A, 2-(bromomethyl)-3,5-difluoropyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, triphenylphosphine (PPh3, 813.5 mg, 3.11 mmol) and carbontetrabromide (CBr4, 823.8 mg, 2.48 mmol) are successively added to tetrahydrofuran (THF, 5.0 ml) containing (3,5-difluoropyridin-2-yl)methanol (300.0 mg, 2.07 mmol) for reaction for 1h at room temperature (r.t.). After reaction is completed, vacuum concentration is directly performed. Obtained residues are purified by silica gel column chromatography (eluent: <semantics>n<annotation encoding="application / x-tex">n< / annotation>< / semantics>-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 372.4 mg of colorless oil 2-(bromomethyl)-3,5-difluoropyridine is obtained (yield: 86.5%). LC-MS: <semantics>RT=1.89 min,[M+H]+=208.01.<annotation encoding="application / x-tex">RT = 1.89 \text{ min}, [M+H]^+ = 208.01.< / annotation>< / semantics> At step В, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H ,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (37.4 mg, 0.18 mmol) and potassium carbonate (K2CO3, 33.12 mg, 0.24 mmol) are added to N,N-dimethylformamide (DMF, containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 28.0 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H ,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 53.7%). LC-MS: RT = 1.86 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 529.22. 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.68 (s, 1H), <semantics>8.60(d,J=2.3Hz,1H),8.13−8.05(m,1H),7.85(dd,J=6.9,2.1Hz,1H),7.78(s,1H),7.69(dd,J=6.9,2.1Hz,1H),7.78(s,1H),7.69(dd,J=6.9,2.1Hz,1H),7.78(s,1H),7.69(dd,J=6.9,2.1Hz,1H),7.78<annotation encoding="application / x-tex">8.60 (d, J = 2.3 Hz, 1H), 8.13-8.05 (m, 1H), 7.85 (dd, J = 6.9, 2.1 Hz, 1H), 7.78 (s, 1H), 7.69 (dd, J = 6.9, 2.1 Hz, 1H), 7.78 (s, 1H), 7.69 (dd, J = 6.9, 2.1 Hz, 1H), 7.78 (s, 1H), 7.69 (dd, J = 6.9, 2.1 Hz, 1H), 7.78< / annotation>< / semantics> <semantics>J=7.0,2.1 Hz,1H,6.79 (s, 1H),6.42 (t, J=7.0 Hz,1H),5.47 (d, J=1.6 Hz,2H),5.22 (s, 1H),<annotation encoding="application / x-tex">J = 7.0, 2.1 \text{ Hz}, 1\text{H}, 6.79 \text{ (s, 1H)}, 6.42 \text{ (t, } J = 7.0 \text{ Hz}, 1\text{H)}, 5.47 \text{ (d, } J = 1.6 \text{ Hz}, 2\text{H)}, 5.22 \text{ (s, 1H)},< / annotation>< / semantics> 2.07 (s, 3H), 2.00 (s, 3H), 1.47 (s, 3H), 1.46 (s, 3H). Supercritical fluid chromatography (AS-H column) is used to separate a racemic Embodiment 1 compound by means of a mobile phase of carbon dioxide and isopropanol, and atropisomer Embodiment 1A and 1B compounds are eluted successively. [Image disponible dans le document PDF, Image available in the PDF document] (-)-Embodiment 1A(+)-Embodiment 1B Embodiment 1A compound: RT = 4.21 min (SFC, AS-H, 0.46 cm I.D. <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 15 cm L column, isogradient method with 30% isopropanol, flow rate being 2.5 mL / min, and cycling time being 10 min). [a]D25=-1.68° (MeOH, Rudolph Autopol I specific rotation instrument); and 1H NMR <Formule mathématique disponible dans le document PDF, Math available in the PDF document>(400 \text{ MHz}, \text{DMSO})\delta 8.68 \text{ (s, 1H)}, 8.59 \text{ (d, J} = 2.3 \text{ Hz, 1H)}, 8.11-8.05 \text{ (m, 1H)}, 7.85 \text{ (dd, J} = 6.9, 1.96)} <semantics>2.0 Hz<annotation encoding="application / x-tex">2.0 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.79 (s, 1H)<annotation encoding="application / x-tex">7.79 \text{ (s, 1H)}< / annotation>< / semantics>, <semantics>7.69 (dd, J=7.0,2.0 Hz<annotation encoding="application / x-tex">7.69 \text{ (dd, J} = 7.0, 2.0 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.80 (s, 1H)<annotation encoding="application / x-tex">6.80 \text{ (s, 1H)}< / annotation>< / semantics>, <semantics>6.42 (t, J=6.9 Hz<annotation encoding="application / x-tex">6.42 \text{ (t, J} = 6.9 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>5.48<annotation encoding="application / x-tex">5.48< / annotation>< / semantics> (d, <semantics>J=1.2<annotation encoding="application / x-tex">J = 1.2< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>5.23<annotation encoding="application / x-tex">5.23< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.07<annotation encoding="application / x-tex">2.07< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>2.00<annotation encoding="application / x-tex">2.00< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.47<annotation encoding="application / x-tex">1.47< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.46<annotation encoding="application / x-tex">1.46< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>). The crystal structure of a single molecule is shown in FIG.1. The main crystal parameters are shown in FIG.2. The atomic coordinates and isotropic displacement parameters of the crystal structure are shown in FIG.3. The bond lengths in the crystal structure are shown in FIG.4. The bond angles in the crystal structure are shown in FIG.5. The dihedral angles in the crystal structure are shown in FIG.6. Embodiment 1B compound: RT = 4.68 min (SFC, AS-H, 0.46 cm I.D. <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 15 cm L column, isogradient method with 30% isopropanol, flow rate being 2.5 mL / min, and cycling time being 10 min). [a] D25+1.64° (MeOH, Rudolph Autopol I specific rotation instrument); and 1H NMR <semantics>(500 MHz,DMSO)δ8.68 (s, 1H),8.59 (d, J= 2.3 Hz, 1H),8.11−8.06 (m, 1H),7.85 (dd, J= 6.9, 1.9)<annotation encoding="application / x-tex">(500 \text{ MHz}, \text{DMSO}) \delta 8.68 \text{ (s, 1H)}, 8.59 \text{ (d, J= 2.3 Hz, 1H)}, 8.11-8.06 \text{ (m, 1H)}, 7.85 \text{ (dd, J= 6.9, 1.9)}< / annotation>< / semantics> <semantics>2.1 Hz<annotation encoding="application / x-tex">2.1 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.78<annotation encoding="application / x-tex">7.78< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>7.69<annotation encoding="application / x-tex">7.69< / annotation>< / semantics> (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, <semantics>2.1 Hz<annotation encoding="application / x-tex">2.1 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.80<annotation encoding="application / x-tex">6.80< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>6.42<annotation encoding="application / x-tex">6.42< / annotation>< / semantics> (t, <semantics>J=6.9 Hz<annotation encoding="application / x-tex">J = 6.9 \text{ Hz}< / annotation>< / semantics>, <semantics>1H<annotation encoding="application / x-tex">1\text{H}< / annotation>< / semantics>), <semantics>5.47 (d, J = 1.3 Hz, 2H),5.24 (s, 1H),2.07 (s, 3H),2.00 (s, 3H),1.47 (s, 3H),1.46 (s, 3H).<annotation encoding="application / x-tex">5.47 \text{ (d, J = 1.3 Hz, 2H)}, 5.24 \text{ (s, 1H)}, 2.07 \text{ (s, 3H)}, 2.00 \text{ (s, 3H)}, 1.47 \text{ (s, 3H)}, 1.46 \text{ (s, 3H)}.< / annotation>< / semantics> Embodiment 2 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 2 is shown as follows. At step A, 2'-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-chloro-5-methylpyridin-4-amine (2.3 g, 1.61 mmol) is dissolved into dioxane (40.0 ml), 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (2.0 g, 1.07 mmol) is added, a temperature is warmed up to 90 degrees Celsius for reaction for 5h, 10N of a sulfuric acid aqueous solution is added dropwise, no solid is produced, and the reaction is continued for 2h. After the reaction is complete, a solvent is spun out; a yellowish precipitate is precipitated by adding an appropriate amount of water; filtering is performed after 0.5h of stirring, and washing is performed with water for two times; and a product of 1.25 g of an earth-yellow solid 2'-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is collected (yield: 30.9%). LC-MS: <semantics>RT=1.65 min,[M+H]+=251.09.<annotation encoding="application / x-tex">RT = 1.65 \text{ min}, [M+H] + = 251.09.< / annotation>< / semantics> At step В, 2'-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (1.55 g, 7.47 mmol) and K2CO3 (1.37 g, 9.96 mmol) are added to N,N-DMF (15.0 ml) containing 2'-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (1.25 g, 4.98 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 1.08 g of a yellowish solid 2'-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: <semantics>57.4%<annotation encoding="application / x-tex">57.4\%< / annotation>< / semantics>). LC-MS: RT = 1.91 min, [M+H]+ = 378.24. At step C, 4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2' :4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, the 2'-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (100.0) mg, 0.26 mmol), 3-(2-hydroxypropane-2-yl)pyridine-2(1H)-one (60.1 mg, 0.39 mmol), Cuprous Iodide (CuI, 9.5 mg, 0.05 mmol), and K2CO3 (71.8 mg, 0.52 mmol) are dissolved in the dioxane (2.0 ml), a drop of N,N-dimethylethylenediamine is added, and then the temperature is warmed up to 110 degrees Celsius for microwave reaction for 1h. After the reaction is completed, suction filtration is performed, drip washing is performed with dichloromethane, and then filtrate is concentrated. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 26.0 mg of a white solid 4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2' :4',1"-terpyridine]-2,2"-diketone is obtained (yield: 20.2%). LC-MS: RT = 1.82 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 495.24. 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.64 (s, 1H), <semantics>8.59 (d, J=2.4 Hz, 1H),8.07 (ddd, J=10.0,9.3,2.4 Hz, 1H),7.84 (dd, J=6.9,2.1 Hz, 1H),<annotation encoding="application / x-tex">8.59 \text{ (d, J} = 2.4 \text{ Hz, 1H)}, 8.07 \text{ (ddd, J} = 10.0, 9.3, 2.4 \text{ Hz, 1H)}, 7.84 \text{ (dd, J} = 6.9, 2.1 \text{ Hz, 1H)},< / annotation>< / semantics> <semantics>7.70<annotation encoding="application / x-tex">7.70< / annotation>< / semantics> (s, 1H), <semantics>7.70−7.66<annotation encoding="application / x-tex">7.70-7.66< / annotation>< / semantics> (m, 1H), <semantics>6.41<annotation encoding="application / x-tex">6.41< / annotation>< / semantics> (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 1H), <semantics>6.13<annotation encoding="application / x-tex">6.13< / annotation>< / semantics> (d, <semantics>J=1.7<annotation encoding="application / x-tex">J = 1.7< / annotation>< / semantics> Hz, 1H), <semantics>6.04<annotation encoding="application / x-tex">6.04< / annotation>< / semantics> (d, <semantics>J=2.5<annotation encoding="application / x-tex">J = 2.5< / annotation>< / semantics> Hz, 1H), 5.25 (s, 2H), 5.22 (s, 1H), 2.08 (s, 3H), 1.90 (s, 3H), 1.47 (s, 3H), 1.46 (s, 3H). Embodiment 3 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 3 is shown as follows. At step A, 2-(bromomethyl)pyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (813.5 mg, 3.11 mmol) and CBr4 (823.8 mg, 2.48 mmol) are added to THF (5.0 ml) containing the 2-(bromomethyl)pyridine (225.6 mg, 2.07 mmol) for reaction for 1h at room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 322.3 mg of colorless oil 2-(bromomethyl)pyridine is obtained (yield: 90.5%). At step В, 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridin-2-yl)methoxy-2H,2"H-[1,2':4',1 "-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] <semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics> At room temperature, 2-(bromomethyl)pyridine (31.0 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 29.0 mg of a white solid 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridin-2-yl)methoxy -2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 49.0%). LC-MS: <semantics>RT=1.77 min<annotation encoding="application / x-tex">RT = 1.77 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=493.34<annotation encoding="application / x-tex">[M+H]^+ = 493.34< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), 8.61-8.58 (m, 1H), 7.91 (td, J = 7.7, 1.8 Hz, 1H), 7.84 (dt, J = <semantics>5.5<annotation encoding="application / x-tex">5.5< / annotation>< / semantics>, <semantics>2.8<annotation encoding="application / x-tex">2.8< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.77<annotation encoding="application / x-tex">7.77< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.68<annotation encoding="application / x-tex">7.68< / annotation>< / semantics> (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, <semantics>2.1<annotation encoding="application / x-tex">2.1< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.58<annotation encoding="application / x-tex">7.58< / annotation>< / semantics> (d, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>7.39<annotation encoding="application / x-tex">7.39< / annotation>< / semantics> (dd, <semantics>J=7.8<annotation encoding="application / x-tex">J = 7.8< / annotation>< / semantics> Hz, <semantics>1H=7.0<annotation encoding="application / x-tex">1H = 7.0< / annotation>< / semantics>), <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics> (d, <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics>), <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics> (d, <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics>), <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics>), <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics>0 (dd, <semantics>1.58<annotation encoding="application / x-tex">1.58< / annotation>< / semantics> <semantics>=7.0,5.3 Hz,1H,6.76 (s, 1H),6.41 (t, J=6.9 Hz,1H),5.42 (s, 2H),5.21 (s, 1H),2.06 (s, 3H),<annotation encoding="application / x-tex">= 7.0, 5.3 \text{ Hz}, 1\text{H}, 6.76 \text{ (s, 1H)}, 6.41 \text{ (t, J} = 6.9 \text{ Hz}, 1\text{H}), 5.42 \text{ (s, 2H)}, 5.21 \text{ (s, 1H)}, 2.06 \text{ (s, 3H)},< / annotation>< / semantics> <semantics>1.99<annotation encoding="application / x-tex">1.99< / annotation>< / semantics> (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=4.1<annotation encoding="application / x-tex">J = 4.1< / annotation>< / semantics> Hz, 6H). Embodiment 4 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 4 is shown as follows. At step A, 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,2,6-trimethyl-4H-1,3-dioxin-4-one (30 g, 211.27 mmol) is dissolved into THF (100 ml), and the temperature is dropped to minus 70 degrees Celsius under nitrogen protection; lithium bis(trimethylsilyl)amide (LiHMDS, 290 ml, 1M) is added dropwise for reaction for 2h; diethylzinc (ZnEt2, 290 ml, 1M) is added for reaction for 0.5h; and the temperature is slowly warmed up to minus 20 degrees Celsius within 1.5h, and 1-acetylimidazole (28 g, 253.52 mmol) is added for reaction for 3h. After the reaction is completed, the reaction is quenched by being poured into ice water; pH=3-4 is adjusted with 6N of hydrochloric acid; extraction is performed with the ethyl acetate <semantics>(50 ml×3 times)<annotation encoding="application / x-tex">(50 \text{ ml} \times 3 \text{ times})< / annotation>< / semantics>, and an organic phase is combined to perform drying; purification is performed through column chromatography (eluent: ethyl acetate / n-hexane = <semantics>4 / 1<annotation encoding="application / x-tex">4 / 1< / annotation>< / semantics>) to obtain 19 g of a yellow solid 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (yield: 49%). LC-MS: RT = 1.65 min, <semantics>[M+H]+=185.13.<annotation encoding="application / x-tex">[M+H]^+ = 185.13.< / annotation>< / semantics> At step B, 2'-bromo-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-bromo-5-methylpyridin-4-amine (5 g, 26.74 mmol) is dissolved into the dioxane (100 ml), 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (5.9 g, 32.09) mmol) is added, the temperature is warmed up to 90 degrees Celsius for reaction for 5h, 10N of the sulfuric acid aqueous solution is added dropwise, until no solid is produced, and the reaction is continued for 2h. After the reaction is complete, concentration is performed to remove the solvent; a yellowish precipitate is precipitated by adding water; filtering is performed after 0.5h of stirring, and washing is performed with water for two times; and a product of 6 g of an earth-yellow solid 2'-bromo-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is collected (yield: 76%). LC-MS: <semantics>RT=1.66 min,[M+H]+=295.11.<annotation encoding="application / x-tex">RT = 1.66 \text{ min}, [M+H]^+ = 295.11.< / annotation>< / semantics> At step C, 2'-bromo-3-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, the 2'-bromo-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (200 mg, 0.68 mmol) is dissolved into isopropanol (Propan-2-ol, 5 ml); N-chlorosuccinimide (NCS, 62 mg, 0.37 mmol) and a drop of 2,2-dichloroacetic acid are added; and the temperature is warmed up to 60 degrees Celsius for reaction for 6h. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate; an organic phase is combined; spin drying is performed; and purification (ethyl acetate) is performed through column chromatography to obtain 100 mg of a white solid 2'-bromo-3-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (yield: 83%). LC-MS: RT <semantics>=1.68 min,[M+H]+=329.06.<annotation encoding="application / x-tex">= 1.68 \text{ min}, [M+H]^{+} = 329.06.< / annotation>< / semantics> At step D, 3-(2-hydroxypropane-2-yl)pyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 78 degrees Celsius, a THF solution (5.47 ml, 1 mol / ml) of methylmagnesium bromide (CH3MgBr) is added dropwise into the THF (5.0 ml) containing 3-acetyl-2(1H)-pyridone (500.0 mg, 3.65 mmol); and the temperature is slowly warmed up to room temperature for reaction for 3h. After the reaction is completed, the reaction is quenched with water; extraction is performed with a mixed solution of dichloromethane and isopropanol (dichloromethane / isopropanol=3 / 1, <semantics>30 ml×5 times<annotation encoding="application / x-tex">30 \text{ ml} \times 5 \text{ times}< / annotation>< / semantics>); an organic phase is combined; washing is performed with saturated salt water <semantics>(30 ml×2 times)<annotation encoding="application / x-tex">(30 \text{ ml} \times 2 \text{ times})< / annotation>< / semantics>; and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 496.0 mg of a white solid 3-(2-hydroxypropane-2-yl)pyridine-2(1H)-one is obtained (yield: 19.0%). LC-MS: RT = 1.33 min, <semantics>[M+H]+=154.14<annotation encoding="application / x-tex">[M+H]^+ = 154.14< / annotation>< / semantics>. At step Ε, 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, the 2'-bromo-3-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (100 mg, 0.30 mmol), 3-(2-hydroxypropane-2-yl)pyridine-2(1H)-one (93 mg, 0.61 mmol), CuI (12 mg, 0.06 mmol), and K2CO3 (84 mg, 0.61 mmol) are dissolved in the dioxane (4 ml), a drop of dimethylethylenediamine is added, and then the temperature is warmed up to 100 degrees Celsius for microwave reaction for 1h. After the reaction is completed, filter is performed; washing is performed with the ethyl acetate; and spin drying is performed on filtrate, and the mixed sample is purified (ethyl acetate) by columns, to obtain 67 mg of a white solid 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] <semantics>−2,2<annotation encoding="application / x-tex">-2,2< / annotation>< / semantics>"-diketone (yield: 55%). LC-MS: RT = 1.70 min, [M+H]+ = 402.20. At step F, 3"-chloro-4"-((2,4-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-fluoro-4-chlorobenzyl bromide (36 mg, 0.17 mmol) and K2CO3 (24 mg, 0.17 mmol) are added to the N,N-DMF (2.0 ml) containing the 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (35 mg, 0.09 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 11.0 mg of a white solid 3"-chloro-4"-((2,4-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is obtained (yield: <semantics>24%<annotation encoding="application / x-tex">24\%< / annotation>< / semantics>). LC-MS: RT = 1.95 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 528.13. Embodiment 5 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 5 is shown as follows. At step A, 2-(bromomethyl)-3-fluoro-5-chloropyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (325 mg, 1.24 mmol) and CBr4 (406 mg, 1.24 mmol) are added to THF (5.0 ml) containing (3-fluoro-5-chloropyridine-2-pyridine)methanol (200 mg, 1.24 mmol) for reaction for 1h at room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 10 / 1). 142 mg of colorless oil 2-(bromomethyl)-3-fluoro-5-chloropyridine is obtained (yield: 51%). At step В, 3"-chloro-4"-((3-fluoro-5-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-fluoro-5-chloropyridine (38 mg, 0.17 mmol) and K2CO3 (24 mg, 0.17 mmol) are added to the N,N-DMF (2.0 ml) containing the 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (35 mg, 0.09 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 14 mg of a white solid 3"-chloro-4"-((3-fluoro-5-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 53.7%). LC-MS: <semantics>RT=1.91 min<annotation encoding="application / x-tex">RT = 1.91 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=545.17<annotation encoding="application / x-tex">[M+H]^+ = 545.17< / annotation>< / semantics>. Embodiment 6 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 6 is shown as follows. At step A, 2-(bromomethyl)pyridazine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (813.5 mg, 3.11 mmol) and CBr4 (823.8 mg, 2.48 mmol) are added to THF (5.0 ml) containing the 2-pyridazinemethanol (227.7 mg, 2.07 mmol) for reaction for 1h at room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 328.5 mg of colorless oil 2-(bromomethyl)pyridazine is obtained (yield: 91.7%). At step В, 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridazin-3-yl)methoxy-2H,2"H-[1,2':4 ',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] ~ At room temperature, 2-(bromomethyl)pyridazine (31.1 mg, 0.18 mmol) and K2CO3 (33.1 mg, 0.24 mmol) are added to the N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 30.5 mg of a white solid 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridazin-3-yl)methoxy-2H,2"H-[1,2':4 ',1"-terpyridine]-2,2"-diketone is obtained (yield: 51.4%). LC-MS: <semantics>RT=1.68 min<annotation encoding="application / x-tex">RT = 1.68 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=494.26<annotation encoding="application / x-tex">[M+H]^+ = 494.26< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 9.26 (dd, J = 4.7, 1.8 Hz, 1H), 8.68 (s, 1H), 7.88-7.82 (m, 3H), 7.77 (s, 1H), 7.68 (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, 2.0 Hz, 1H), 6.82 (s, 1H), 6.41 (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 1H), 5.65 (s, 2H), 5.21 (s, 1H), <semantics>2.07<annotation encoding="application / x-tex">2.07< / annotation>< / semantics> (s, 3H), <semantics>2.00<annotation encoding="application / x-tex">2.00< / annotation>< / semantics> (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=4.0<annotation encoding="application / x-tex">J = 4.0< / annotation>< / semantics> Hz, 6H). Embodiment 7 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 7 is shown as follows. At step Α, 3"-chloro-3-(2-hydroxypropane-2-yl)-4"-((3-methoxypyridine-2-yl)methoxy)-5',6"-dimethyl-2H, 2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-methoxypyridine (36.4 mg, 0.18 mmol) and K2CO3 (33.1 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml × 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 24 mg of a white solid 3"-chloro-4"-(pyridin-4-ylmethoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1' '-terpyridine]-2,2"-diketone is obtained (yield: 38.3%). LC-MS: <semantics>RT=1.79min<annotation encoding="application / x-tex">RT = 1.79min< / annotation>< / semantics>, <semantics>[M+H]+=523.28<annotation encoding="application / x-tex">[M+H]^+ = 523.28< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), 8.20-8.16 (m, 1H), 7.84 (dd, J = 6.9, 2.0 Hz, 1H), 7.77 (s, 1H), 7.68 (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, 2.1 Hz, 1H), 7.56 (d, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics> Hz, 1H), 7.44 (dd, <semantics>J=8.4<annotation encoding="application / x-tex">J = 8.4< / annotation>< / semantics>, 4.6 Hz, 1H), 6.76 (s, 1H), 6.41 (t, <semantics>J=6.9 Hz<annotation encoding="application / x-tex">J = 6.9 \text{ Hz}< / annotation>< / semantics>, 1H), 5.36 (s, 2H), 5.21 (s, 1H), 3.88 (s, 3H), 2.06 (s, 3H), 1.98 (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=4.2<annotation encoding="application / x-tex">J = 4.2< / annotation>< / semantics> Hz, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>). Embodiment 8 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 8 is shown as follows. At step A, 4-(((3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2,2"-dioxo-2H,2"H-[1,2 2':4',1"-terpyridine]-4"-yl)oxy)methyl)-3-fluorobenzonitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 4-(bromomethyl)-3-fluorobenzonitrile (38.16 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 26.5 mg of a white solid 4-(((3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2,2"-dioxo-2H,2"H-[1,2 2':4',1"-terpyridine]-4"-yl)oxy)methyl)-3-fluorobenzonitrile is obtained (yield: 41.3%). LC-MS: <semantics>RT=1.79min<annotation encoding="application / x-tex">RT = 1.79min< / annotation>< / semantics>, <semantics>[M+H]+=535.23<annotation encoding="application / x-tex">[M+H]^+ = 535.23< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400 MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.68 (s, 1H), 7.97 (d, J = 9.6 Hz, 1H), 7.83 (dt, J = 10.8, 3.4 Hz, 3H), 7.77 (s, 1H), 7.68 (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, 2.0 Hz, 1H), 6.80 (s, 1H), 6.41 (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 1H), 5.49 (s, 2H), 5.21 (s, 1H), <semantics>2.07(d,J=8.7Hz,3H),2.00(s,3H),1.45(d,J=3.9Hz,6H).<annotation encoding="application / x-tex">2.07 (d, J = 8.7 Hz, 3H), 2.00 (s, 3H), 1.45 (d, J = 3.9 Hz, 6H).< / annotation>< / semantics> Embodiment 9 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 9 is shown as follows. At step Α, 3"-chloro-4"-((4-chloro-2-fluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H- [1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-fluoro-4-chlorobenzyl bromide (122 mg, 0.50 mmol) and K2CO3 (69 mg, 0.50 mmol) are added to the N,N-DMF (2.5 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (100 mg, 0.25 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 50 mg of a white solid 3"-chloro-4"-((4-chloro-2-fluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H- [1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 36%). LC-MS: RT = <semantics>2.02 min<annotation encoding="application / x-tex">2.02 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=544.18<annotation encoding="application / x-tex">[M+H]^+ = 544.18< / annotation>< / semantics>. 1H NMR (<semantics>400 MHz<annotation encoding="application / x-tex">400 \text{ MHz}< / annotation>< / semantics>, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), <semantics>7.84 (dd, J=6.9,2.1 Hz, 1H),7.77 (s, 1H),7.72−7.61 (m, 2H),7.55 (dd, J=10.0,2.0 Hz, 1H),<annotation encoding="application / x-tex">7.84 \text{ (dd, J} = 6.9, 2.1 \text{ Hz, 1H)}, 7.77 \text{ (s, 1H)}, 7.72-7.61 \text{ (m, 2H)}, 7.55 \text{ (dd, J} = 10.0, 2.0 \text{ Hz, 1H)},< / annotation>< / semantics> <semantics>7.40 (dd, J=8.3,1.8 Hz, 1H),6.79 (s, 1H),6.41 (t, J=7.0 Hz, 1H),5.37 (s, 2H),5.21 (s, 1H),<annotation encoding="application / x-tex">7.40 \text{ (dd, J} = 8.3, 1.8 \text{ Hz, 1H)}, 6.79 \text{ (s, 1H)}, 6.41 \text{ (t, J} = 7.0 \text{ Hz, 1H)}, 5.37 \text{ (s, 2H)}, 5.21 \text{ (s, 1H)},< / annotation>< / semantics> <semantics>2.06<annotation encoding="application / x-tex">2.06< / annotation>< / semantics> (s, 3H), <semantics>2.00<annotation encoding="application / x-tex">2.00< / annotation>< / semantics> (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=3.9<annotation encoding="application / x-tex">J = 3.9< / annotation>< / semantics> Hz, 6H). Embodiment 10 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 10 is shown as follows. At step Α, 3"-chloro-4"-((5-(trifluoromethyl)pyridin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-5-(trifluoromethyl)pyridine (43.2 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 11.0 mg of a white solid 3"-chloro-4"-((5-(trifluoromethyl)pyridin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 16.3%). LC-MS: <semantics>RT=1.93 min,[M+H]+=561.23.<annotation encoding="application / x-tex">RT = 1.93 \text{ min}, [M+H]^+ = 561.23.< / annotation>< / semantics> Embodiment 11 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 11 is shown as follows. At step Α, 3"-chloro-4"-((pyridin-4-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4', 1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 4-(bromomethyl)pyridine (45.5 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml × 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 10.0 mg of a white solid 3"-chloro-4"-((pyridin-4-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4', 1"-terpyridine]-2,2"-diketone is obtained (yield: <semantics>16.9%<annotation encoding="application / x-tex">16.9\%< / annotation>< / semantics>). LC-MS: RT = <semantics>1.61<annotation encoding="application / x-tex">1.61< / annotation>< / semantics> min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 493.24. Embodiment 12 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 12 is shown as follows. At step Α, 3"-chloro-4"-((3-methylpyridin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(chloromethyl)-3-methylpyridine (71 mg, 0.50 mmol) and K2CO3 (69 mg, 0.50 mmol) are added to the N,N-DMF (2.5 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (100 mg, 0.25 mmol) for reaction for 4h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 21 mg of a white solid 3"-chloro-4"-((3-methylpyridin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 16%). LC-MS: <semantics>RT=1.75 min,[M+H]+=507.21.<annotation encoding="application / x-tex">RT = 1.75 \text{ min}, [M+H]^+ = 507.21.< / annotation>< / semantics> Embodiment 13 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 13 is shown as follows. At step Α, 2-(((3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2,2"-dione-2H,2"H-[1,2':4',1"-terpyridi ne]-4"-yl)oxy)methyl)-3-fluorobenzonitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-fluorobenzonitrile (38.16 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 29.5 mg of a white solid 2-(((3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2,2"-dione-2H,2"H-[1,2':4',1"-terpyridi ne]-4"-yl)oxy)methyl)-3-fluorobenzonitrile is obtained (yield: 45.9%). LC-MS: RT = 1.88 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 535.21. 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.70 (s, 1H), <semantics>7.92−7.84<annotation encoding="application / x-tex">7.92-7.84< / annotation>< / semantics> (m, 2H), <semantics>7.82<annotation encoding="application / x-tex">7.82< / annotation>< / semantics> (s, 1H), <semantics>7.80−7.73<annotation encoding="application / x-tex">7.80-7.73< / annotation>< / semantics> (m, 2H), <semantics>7.70<annotation encoding="application / x-tex">7.70< / annotation>< / semantics> (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, 2.1 Hz, 1H), <semantics>6.88<annotation encoding="application / x-tex">6.88< / annotation>< / semantics> (s, 1H), <semantics>6.43<annotation encoding="application / x-tex">6.43< / annotation>< / semantics> (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>5.46<annotation encoding="application / x-tex">5.46< / annotation>< / semantics> (s, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>5.23<annotation encoding="application / x-tex">5.23< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.09<annotation encoding="application / x-tex">2.09< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>2.05<annotation encoding="application / x-tex">2.05< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.48<annotation encoding="application / x-tex">1.48< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.47<annotation encoding="application / x-tex">1.47< / annotation>< / semantics> (s, 3H). Embodiment 14 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 14 is shown as follows. At step Α, 3"-chloro-4"-((5-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-5-chloropyridine (36.9 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 14.6 mg of a white solid 3"-chloro-4"-((5-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 23.1%). LC-MS: RT = <semantics>1.89 min<annotation encoding="application / x-tex">1.89 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=527.20<annotation encoding="application / x-tex">[M+H]^+ = 527.20< / annotation>< / semantics>. Embodiment 15 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 15 is shown as follows. At step Α, 3"-chloro-4"-((2,6-difluorophenyl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[ 1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-1,3-difluorobenzene (37.26 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 15.31 mg of a white solid 3"-chloro-4"-((2,6-difluorophenyl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[ 1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 24.1%). [Image disponible dans le document PDF, Image available in the PDF document] Embodiment 16 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 16 is shown as follows. At step A, 2-(bromomethyl)-3-fluoro-5-bromopyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (267 mg, 1.02 mmol) and CBr4 (334 mg, 1.02 mmol) are successively added to THF (10 ml) containing (3-fluoro-5-bromopyridine-2-pyridine)methanol (210 mg, 1.02 mmol) for reaction for 1h at room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: <semantics>n<annotation encoding="application / x-tex">n< / annotation>< / semantics>-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 200 mg of colorless oil 2-(bromomethyl)-3-fluoro-5-bromopyridine is obtained (yield: 73%). At step В, 3"-chloro-4"-((3-fluoro-5-bromopyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-bromo-5-fluoropyridine (134 mg, 0.50 mmol) and K2CO3 (39 mg, 0.50 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (100 mg, 0.25 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 14 mg of a white solid 3"-chloro-4"-((3-fluoro-5-bromopyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 53.7%). LC-MS: <semantics>RT=1.91 min,[M+H]+=589.13.<annotation encoding="application / x-tex">RT = 1.91 \text{ min}, [M+H]^+ = 589.13.< / annotation>< / semantics> Embodiment 17 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 17 is shown as follows. At step Α, 3"-chloro-4"-((2,3-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,3-difluorobenzyl bromide (31 mg, 0.149 mmol) and K2CO3 (35 mg, 0.50 mmol) are added to the N,N-DMF (2.5) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50 mg, 0.124 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 6.8 mg of a white solid 3"-chloro-4"-((2,3-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is obtained (yield: 10%). LC-MS: <semantics>RT=1.97 min,[M+H]+=528.18.<annotation encoding="application / x-tex">RT = 1.97 \text{ min}, [M+H]^+ = 528.18.< / annotation>< / semantics> Embodiment 18 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 18 is shown as follows. At step Α, 3"-chloro-4"-((2,5-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,5-difluorobenzyl bromide (31 mg, 0.149 mmol) and K2CO3 (35 mg, 0.50 mmol) are added to the N,N-DMF (2.5) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50 mg, 0.124 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>). 7.8 mg of a white solid 3"-chloro-4"-((2,5-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is obtained (yield: 12%). LC-MS: <semantics>RT=1.93 min,[M+H]+=528.21.<annotation encoding="application / x-tex">RT = 1.93 \text{ min}, [M+H]^+ = 528.21.< / annotation>< / semantics> Embodiment 19 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 19 is shown as follows. At step Α, 3"-chloro-4"-((3-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 3-chloro-2-(chloromethyl)pyridine (29.2 mg, 0.18 mmol) and K2CO3 (33.12) mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 4h at 60 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 19.8 mg of a white solid 3"-chloro-4"-((3-chloropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 31.3%). LC-MS: <semantics>RT=1.84 min<annotation encoding="application / x-tex">RT = 1.84 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=527.20<annotation encoding="application / x-tex">[M+H]^+ = 527.20< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), 8.59 (dd, J = 4.7, 1.4 Hz, 1H), 8.05 (dd, J = 8.1, 1.4 Hz, 1H), <Formule mathématique disponible dans le document PDF, Math available in the PDF document>7.84 \text{ (dd, J} = 6.9, 2.1 \text{ Hz}, 1\text{H}), 7.78 \text{ (s, 1H)}, 7.68 \text{ (dt, J} = 9.0, 2.0 \text{ Hz}, 1\text{H}), 7.51 \text{ (dd, J} = 8.1, 4.7)} Hz, 1H), <semantics>6.76<annotation encoding="application / x-tex">6.76< / annotation>< / semantics> (s, 1H), <semantics>6.41<annotation encoding="application / x-tex">6.41< / annotation>< / semantics> (t, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics> Hz, 1H), <semantics>5.48<annotation encoding="application / x-tex">5.48< / annotation>< / semantics> (d, <semantics>J=12.4<annotation encoding="application / x-tex">J = 12.4< / annotation>< / semantics> Hz, 2H), <semantics>5.21<annotation encoding="application / x-tex">5.21< / annotation>< / semantics> (s, 1H), <semantics>2.07<annotation encoding="application / x-tex">2.07< / annotation>< / semantics> (s, 3H), <semantics>1.98<annotation encoding="application / x-tex">1.98< / annotation>< / semantics> (s, 3H), <semantics>1.46<annotation encoding="application / x-tex">1.46< / annotation>< / semantics> (d, <semantics>J=4.1<annotation encoding="application / x-tex">J = 4.1< / annotation>< / semantics> Hz, 6H). Embodiment 20 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 20 is shown as follows. At step Α, 3"-chloro-4"-((3-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 3-fluoro-2-(chloromethyl)pyridine (26.2 mg, 0.18 mmol) and K2CO3 (33.12) mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 4h at 60 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 23.0 mg of a white solid 3"-chloro-4"-((3-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 37.5%). LC-MS: <semantics>RT=1.79 min<annotation encoding="application / x-tex">RT = 1.79 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=511.20<annotation encoding="application / x-tex">[M+H]^+ = 511.20< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) δ 8.67 (s, 1H), 8.51-8.47 (m, 1H), 7.86-7.82 (m, 2H), 7.78 (s, 1H), 7.68 (dd, J <semantics>=7.0,2.1 Hz,1H,7.57 (dt, J=8.6,4.4 Hz,1H),6.80 (s, 1H),6.41 (t, J=6.9 Hz,1H),5.48 (d, J=8.6,4.4 Hz,1.4 Hz)<annotation encoding="application / x-tex">= 7.0, 2.1 \text{ Hz}, 1\text{H}, 7.57 \text{ (dt, } J = 8.6, 4.4 \text{ Hz}, 1\text{H}), 6.80 \text{ (s, } 1\text{H}), 6.41 \text{ (t, } J = 6.9 \text{ Hz}, 1\text{H}), 5.48 \text{ (d, } J = 8.6, 4.4 \text{ Hz}, 1.4 \text{ Hz})< / annotation>< / semantics> <semantics>=1.6 Hz,2H,5.21 (s, 1H),2.07 (s, 3H),1.99 (s, 3H),1.46 (d, J=4.1 Hz, 6H).<annotation encoding="application / x-tex">= 1.6 \text{ Hz}, 2\text{H}, 5.21 \text{ (s, 1H)}, 2.07 \text{ (s, 3H)}, 1.99 \text{ (s, 3H)}, 1.46 \text{ (d, J} = 4.1 \text{ Hz, 6H)}.< / annotation>< / semantics> Embodiment 21 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 21 is shown as follows. At step Α, 3"-chloro-4"-((5-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-5-fluoropyridine (34.38 mg, 0.18 mmol) and K2CO3 (33.12) mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml × 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 11.0 mg of a white solid 3"-chloro-4"-((5-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2" H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 18.0%). LC-MS: <semantics>RT=1.82 min<annotation encoding="application / x-tex">RT = 1.82 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=511.23<annotation encoding="application / x-tex">[M+H]^+ = 511.23< / annotation>< / semantics>. Embodiment 22 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 22 is shown as follows. At step Α, 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyrimidin-4-yl)methoxy)-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] <semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics> At room temperature, 4-(bromomethyl)pyridine (31.1 mg, 0.18 mmol) and K2CO3 (33.1 mg, 0.24 mmol) are added to the N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 31.5 mg of a white solid 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyrimidin-4-yl)methoxy-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is obtained (yield: 53.2%). LC-MS: <semantics>RT=1.70 min<annotation encoding="application / x-tex">RT = 1.70 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=494.19<annotation encoding="application / x-tex">[M+H]^+ = 494.19< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 9.22 (s, 1H), 8.92 (s, 1H), 8.68 (s, 1H), 7.85 (dd, J = 7.0, 2.1 Hz, 1H), 7.77 (s, 1H), <semantics>7.71−7.63<annotation encoding="application / x-tex">7.71-7.63< / annotation>< / semantics> (m, 2H), <semantics>6.73<annotation encoding="application / x-tex">6.73< / annotation>< / semantics> (s, 1H), <semantics>6.41<annotation encoding="application / x-tex">6.41< / annotation>< / semantics> (t, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics> Hz, 1H), <semantics>5.48<annotation encoding="application / x-tex">5.48< / annotation>< / semantics> (s, 2H), <semantics>5.21<annotation encoding="application / x-tex">5.21< / annotation>< / semantics> (s, 1H), <semantics>2.06<annotation encoding="application / x-tex">2.06< / annotation>< / semantics> (s, 2H), <semantics>1.98<annotation encoding="application / x-tex">1.98< / annotation>< / semantics> (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=4.1<annotation encoding="application / x-tex">J = 4.1< / annotation>< / semantics> Hz, 6H). Embodiment 23 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 23 is shown as follows. At step Α, 3"-chloro-4"-((3,4-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 3,4-difluorobenzyl bromide (31 mg, 0.149 mmol) and K2CO3 (35 mg, 0.50 mmol) are added to the N,N-DMF (2.5 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50 mg, 0.124 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 6.5 mg of a white solid 3"-chloro-4"-((3,4-difluorobenzyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2': 4',1"-terpyridine]-2,2"-diketone is obtained (yield: 10%). LC-MS: <semantics>RT=1.95 min<annotation encoding="application / x-tex">RT = 1.95 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=528.22<annotation encoding="application / x-tex">[M+H]^+ = 528.22< / annotation>< / semantics>. Embodiment 24 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 24 is prepared by means of the following method. At step Α, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (160 mg, 0.77 mmol) and K2CO3 (177 mg, 1.28 mmol) are added to an N,N-DMF solution (2.0 ml) containing the 2'-bromo-3-chloro-4-hydroxyl-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (211 mg, 0.64 mmol) for reaction for 1h at room temperature. After the reaction is completed, water (10.0 ml) is added, and then a solid is precipitated and filtered; the obtained filter cake is washed with water for two times; and decompression drying is performed, to obtain 290 mg of a yellowish solid 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne is obtained (yield: 99%). LC-MS: <semantics>RT=1.91 min<annotation encoding="application / x-tex">RT = 1.91 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=458.03<annotation encoding="application / x-tex">[M+H]^+ = 458.03< / annotation>< / semantics>. At step В, 3-acetyl-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-ter pyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, a 1,4-dioxane solution (5.0) ml) containing 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (100 mg, 0.22 mmol), 3-acetylpyridine-2(1H)-one (36 mg, 0.26 mmol), K2CO3 (60 mg, 0.44 mmol), CuI (8 mg, 0.044 mmol) and dimethylethylenediamine (8 mg, 0.087 mmol) is degassed, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; filtrate is concentrated; and obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>). 105 mg of a white solid 3-acetyl-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-ter pyridine]-2,2"-diketone is obtained (yield: 93.7%). LC-MS: <semantics>RT=1.84 min<annotation encoding="application / x-tex">RT = 1.84 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=513.16<annotation encoding="application / x-tex">[M+H]^+ = 513.16< / annotation>< / semantics>. At step C, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(1-hydroxyethyl)-5',6"-dimethyl-2H,2"H-[1 ,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, sodium borohydride (6 mg, 0.15 mmol) is added to a methanol solution (MeOH, 2.0 ml) containing 3-acetyl-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-ter pyridine]-2,2"-diketone (50 mg, 0.097 mmol), for reaction for 0.5h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (3 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (5 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0), and then 36 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(1-hydroxyethyl)-5',6"-dimethyl-2H,2"H-[1 ,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 72%). LC-MS: RT = 1.84 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 513.16. 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), <semantics>8.59<annotation encoding="application / x-tex">8.59< / annotation>< / semantics> (d, <semantics>J=2.3<annotation encoding="application / x-tex">J = 2.3< / annotation>< / semantics> Hz, 1H), <semantics>8.12−8.04<annotation encoding="application / x-tex">8.12-8.04< / annotation>< / semantics> (m, 1H), <semantics>7.89−7.83<annotation encoding="application / x-tex">7.89-7.83< / annotation>< / semantics> (m, 1H), <semantics>7.79<annotation encoding="application / x-tex">7.79< / annotation>< / semantics> (d, <semantics>J=11.5<annotation encoding="application / x-tex">J = 11.5< / annotation>< / semantics> Hz, 1H), <semantics>7.60−7.53<annotation encoding="application / x-tex">7.60-7.53< / annotation>< / semantics> (m, 1H), <semantics>6.79<annotation encoding="application / x-tex">6.79< / annotation>< / semantics> (s, 1H), <semantics>6.43<annotation encoding="application / x-tex">6.43< / annotation>< / semantics> (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 1H), <semantics>5.49<annotation encoding="application / x-tex">5.49< / annotation>< / semantics> (t, <semantics>J=9.4<annotation encoding="application / x-tex">J = 9.4< / annotation>< / semantics> Hz, 2H), <semantics>5.15−5.08<annotation encoding="application / x-tex">5.15-5.08< / annotation>< / semantics> (m, 1H), <semantics>4.73<annotation encoding="application / x-tex">4.73< / annotation>< / semantics> (dd, <semantics>J=10.7<annotation encoding="application / x-tex">J = 10.7< / annotation>< / semantics>, <semantics>5.6<annotation encoding="application / x-tex">5.6< / annotation>< / semantics> Hz, 1H), <semantics>2.06<annotation encoding="application / x-tex">2.06< / annotation>< / semantics> (s, 3H), <semantics>2.00<annotation encoding="application / x-tex">2.00< / annotation>< / semantics> (s, 3H), <semantics>1.26<annotation encoding="application / x-tex">1.26< / annotation>< / semantics> (dd, <semantics>J=8.8<annotation encoding="application / x-tex">J = 8.8< / annotation>< / semantics>, <semantics>6.3<annotation encoding="application / x-tex">6.3< / annotation>< / semantics> Hz, 3H). Embodiment 25 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 25 is shown as follows. At step A, 2-(bromomethyl)-3-chloro-5-fluoropyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (813.5 mg, 3.11 mmol) and CBr4 (823.8 mg, 2.48 mmol) are added to THF (5.0 ml) containing the (3-chloro-5-fluoropyridine-2-yl)methanol (334.4 mg, 2.07 mmol), for reaction for 1h by warming up the temperature to room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: <semantics>n<annotation encoding="application / x-tex">n< / annotation>< / semantics>-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>). 380.6 mg of colorless oil 2-(bromomethyl)-3-chloro-5-fluoropyridine is obtained (yield: 81.9%). At step В, 3"-chloro-4"-((3-chloro-5-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-chloro-5-fluoropyridine (40.4 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 15.31 mg of a white solid 3"-chloro-4"-((3-chloro-5-fluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimeth yl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 25.7%). LC-MS: <semantics>RT=1.89min<annotation encoding="application / x-tex">RT = 1.89min< / annotation>< / semantics>, <semantics>[M+H]+=545.17<annotation encoding="application / x-tex">[M+H]^+ = 545.17< / annotation>< / semantics>. Embodiment 26 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 26 is prepared by means of the following method. At step A, 3-(2-hydroxybutane-2-yl)pyridine-2-(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 3-acetylpyridine-2(1H)-one (300.0 mg, 2.2 mmol) is dissolved in THF (10.0 ml), and nitrogen replacement is performed for 3 times; the temperature is cooled to minus 20 degrees Celsius; and ethylmagnesium bromide (EtMgBr, 6.6 ml, 1.0 mol / l) is slowly added dropwise, and after the EtMgBr is added, reaction is performed for 1h by slowly warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched by adding a saturated ammonium chloride solution (25.0 ml) at zero degrees Celsius; extraction is performed with ethyl acetate (15 <semantics>ml×5<annotation encoding="application / x-tex">ml \times 5< / annotation>< / semantics> times); an organic phase is combined; washing is performed with saturated salt water (10) <semantics>ml×1<annotation encoding="application / x-tex">ml \times 1< / annotation>< / semantics> time); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 1 / 3). 200.0 mg of colorless oil 3-(2-hydroxybutane-2-yl)pyridine-2(1H)-one is obtained (yield: 54.1%). LC-MS: RT = 1.57 min, <semantics>[M+H]+=168.17.<annotation encoding="application / x-tex">[M+H]^+ = 168.17.< / annotation>< / semantics> At step В, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxybutane-2-yl)-5',6"-dimethyl-2H, 2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (200.0 mg, 0.5 mmol), 3-(2-hydroxybutane-2-yl)pyridine-2-(1H)-one (109.7 mg, 0.6 mmol) and K2CO3 (138.0 mg, 1.0 mmol) are dissolved in 1,4-dioxane (5.0 ml); CuI (18.2 mg, 1.0 mmol) and dimethylethylenediamine (0.01 ml) are added; and nitrogen replacement is performed for 3 times, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 1 time); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = 1 / 20). 90.0 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxybutane-2-yl)-5',6"-dimethyl-2H, 2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 34.6%). LC-MS: <semantics>RT=1.89 min,[M+H]+=543.27.<annotation encoding="application / x-tex">RT = 1.89 \text{ min}, [M+H]^+ = 543.27.< / annotation>< / semantics> Embodiment 27 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 27 is shown as follows. At step A, (3-fluoro-5-cyclopropylpyridine-2-yl)methanol is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, cyclopropylboronic acid (177 mg, 2.24 mmol), a palladium catalyst (Pd(dppf)Cl2, 82 mg, 0.11 mmol) and K2CO3 (309 mg, 2.24 mmol) are added to a mixed solvent (dioxane / water=5 / 1, 18 ml) containing (3-fluoro-5-bromopyridine-2-yl)methanol (230 mg, 1.12 mmol), for reaction for 8h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, filter is performed; filtrate is concentrated, and diluted by adding water; extraction is performed with ethyl acetate (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 10), to obtain 80 mg of colourless liquid (3-fluoro-5-cyclopropylpyridine-2-yl)methanol (yield: 43%). At step B, 2-(bromomethyl)-3-fluoro-5-cyclopropylpyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (126 mg, 0.48 mmol) and CBr4 (157 mg, 0.48 mmol) are added to THF (5 ml) containing (3-fluoro-5-cyclopropylpyridine-2-yl)methanol (80 mg, 0.48 mmol), for reaction for 1h at room temperature. After the reaction is completed, concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: <semantics>n<annotation encoding="application / x-tex">n< / annotation>< / semantics>-hexane / ethyl acetate = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>), to obtain 40 mg of colorless oil 2-(bromomethyl)-3-fluoro-5-cyclopropylpyridine (yield: 36%). At step C, 3"-chloro-4"-((3-fluoro-5-cyclopropylpyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3-fluoro-5-cyclopropylpyridine (40 mg, 0.17 mmol) and K2CO3 (48 mg, 0.35 mmol) are added to the N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (68 mg, 0.17 mmol) for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>), to obtain 1.07 mg of a white solid 3"-chloro-4"-((3-fluoro-5-cyclopropylpyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone (yield: 1%). LC-MS: <semantics>RT=1.91 min,[M+H]+=551.21.<annotation encoding="application / x-tex">RT = 1.91 \text{ min}, [M+H]^+ = 551.21.< / annotation>< / semantics> Embodiment 28 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 28 is shown as follows. At step Α, 3"-chloro-4"-((pyrazin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4', 1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)pyrazine (31.14 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml × 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 12.0 mg of a white solid 3"-chloro-4"-((pyrazin-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4', 1"-terpyridine]-2,2"-diketone is obtained (yield: 20.3%). LC-MS: <semantics>RT=1.72 min,[M+H]+=494.23.<annotation encoding="application / x-tex">RT = 1.72 \text{ min}, [M+H]^+ = 494.23.< / annotation>< / semantics> Embodiment 29 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 29 is prepared by means of the following method. At step A, 3-acetyl-4-methylpyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (350.0 mg, 2.6 mmol) is dissolved in THF (10.0 ml), and nitrogen replacement is performed for 3 times; the temperature is cooled to minus 20 degrees Celsius; MeMgBr (2.2 ml, 3.0 mol / l) is added dropwise, and after the MeMgBr is added, reaction is performed for 2h by slowly warming up the temperature to room temperature; reaction is performed for 1h by warming up the temperature to 40 degrees Celsius; and 10 mg, 1 mol / l of hydrochloric acid is added, and reaction is performed for 1h by cooling the temperature to room temperature. After the reaction is completed, the reaction is quenched by adding 25.0 ml of a saturated sodium bicarbonate solution; extraction is performed with ethyl acetate (15 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 1 time); and drying is performed with anhydrous sodium sulfate, and then concentration is performed, to obtain 350.0 mg of a yellowish solid 3-acetyl-4-methylpyridine-2(1H)-one (yield: 89.1%). LC-MS: <semantics>RT=1.21 min,[M+H]+=152.10.<annotation encoding="application / x-tex">RT = 1.21 \text{ min}, [M+H]^+ = 152.10.< / annotation>< / semantics> At step B, 3-(2-hydroxypropane-2-yl)-4-methylpyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 3-acetyl-4-methylpyridine-2(1H)-one (350.0 mg, 2.3 mmol) is dissolved in THF (10.0 ml), and nitrogen replacement is performed for 3 times; the temperature is cooled to minus 20 degrees Celsius; and MeMgBr (2.3 ml, 3.0 mol / l) is added dropwise, and after the MeMgBr is added, reaction is performed for 2h by slowly warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched by adding the saturated ammonium chloride solution (30.0 ml); extraction is performed with ethyl acetate (15 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 5 times); an organic phase is combined; washing is performed with saturated salt water (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 1 time); drying is performed with anhydrous sodium sulfate, and then concentration is performed; and obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = <semantics>1 / 20<annotation encoding="application / x-tex">1 / 20< / annotation>< / semantics>), to obtain <semantics>106.0<annotation encoding="application / x-tex">106.0< / annotation>< / semantics> mg of a yellowish solid 3-(2-hydroxypropane-2-yl)-4-methylpyridine-2(1H)-one (yield: 27.5%). LC-MS: RT = 1.57 min, <semantics>[M+H]+=168.17.<annotation encoding="application / x-tex">[M+H]^+ = 168.17.< / annotation>< / semantics> At step C, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-4,5',6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (100.0 mg, 0.2 mmol), 3-(2-hydroxybutane-2-yl)-4-methylpyridine-2-(1H)-one (54.8 mg, 0.3 mmol) and K2CO3 (58.0 mg, 0.4 mmol) are dissolved in 1,4-dioxane (5.0 ml); CuI (8.0 mg, 0.4 mmol) and dimethylethylenediamine (0.01 ml) are added; and nitrogen replacement is performed for 3 times, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 1 time); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = <semantics>1 / 20<annotation encoding="application / x-tex">1 / 20< / annotation>< / semantics>). 50.0 mg of a yellowish solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-4,5',6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 43.9%). LC-MS: RT = 1.89 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 543.24. H NMR (400 MHz, DMSO): <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> = 8.66 (s, 1H), <semantics>8.59 (d, J=2.4 Hz, 1H),8.10−8.05 (m, 1H),7.74 (d, J=1.7 Hz, 1H),6.79 (s, 1H),6.21 (d, J=1.7 Hz, 1H)<annotation encoding="application / x-tex">8.59 \text{ (d, J} = 2.4 \text{ Hz, 1H)}, 8.10 - 8.05 \text{ (m, 1H)}, 7.74 \text{ (d, J} = 1.7 \text{ Hz, 1H)}, 6.79 \text{ (s, 1H)}, 6.21 \text{ (d, J} = 1.7 \text{ Hz, 1H)}< / annotation>< / semantics> 7.3 Hz, 1H), 5.90 (s, 1H), 5.47 (d, <semantics>J=1.5<annotation encoding="application / x-tex">J = 1.5< / annotation>< / semantics> Hz, 2H), 3.57 (s, 1H), 2.44 (s, 3H), 2.06 (s, 3H), 1.99 <semantics>(s,3H),1.53(d,J=3.3Hz,6H).<annotation encoding="application / x-tex">(s, 3H), 1.53 (d, J = 3.3 Hz, 6H).< / annotation>< / semantics> Embodiment 30 [Image disponible dans le document PDF, Image available in the PDF document] A specific synthetic route of a compound with a serial number being 30 is shown as follows. At step Α, 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridin-3-yl)methoxy)-2H,2"H-[1,2':4', 1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] <semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics> At room temperature, 3-(bromomethyl)pyridine (31.0 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to the N,N-DMF (2.0) ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol) for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 29.6 mg of a white solid 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((pyridin-3-yl)methoxy-2H,2"H-[1,2':4',1 "-terpyridine]-2,2"-diketone is obtained (yield: 40.1%). LC-MS: <semantics>RT=1.64 min<annotation encoding="application / x-tex">RT = 1.64 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=493.22<annotation encoding="application / x-tex">[M+H]^+ = 493.22< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.71 (d, J = 1.7 Hz, 1H), 8.67 (s, 1H), 8.59 (dd, J = 4.8, 1.5 Hz, 1H), 7.91 (d, <semantics>J=7.9 Hz<annotation encoding="application / x-tex">J = 7.9 \text{ Hz}< / annotation>< / semantics>, 1H), 7.84 (dd, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics>, 2.0 Hz, 1H), 7.77 (s, 1H), 7.68 (dd, <semantics>J=7.0<annotation encoding="application / x-tex">J = 7.0< / annotation>< / semantics>, 2.1 Hz, 1H), 7.48 <semantics>(dd,J=7.8,4.8Hz,1H),6.77(s,1H),6.41(t,J=7.0Hz,1H),5.40(s,2H),5.21(s,1H),2.06(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),5.21(s,2H),<annotation encoding="application / x-tex">(dd, J = 7.8, 4.8 Hz, 1H), 6.77 (s, 1H), 6.41 (t, J = 7.0 Hz, 1H), 5.40 (s, 2H), 5.21 (s, 1H), 2.06 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H), 5.21 (s, 2H),< / annotation>< / semantics> 3H), <semantics>2.00<annotation encoding="application / x-tex">2.00< / annotation>< / semantics> (s, 3H), <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=3.8<annotation encoding="application / x-tex">J = 3.8< / annotation>< / semantics> Hz, 6H). Embodiment 31 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 31 is prepared by means of the following method. At step A, 3-acetyl-4-methoxypyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, MeMgBr (1.33 ml, 4.00 mmol, 3 mol / ml) is added to a THF solution (4.0 ml) containing 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile (200 mg, 1.33 mmol), for reaction for 1h by warming up the temperature to room temperature; and an aqueous hydrochloric acid solution (1 ml, 1 mol / ml) is added, and the reaction is continued for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (5ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3times); an organic phase is combined; washing is performed with saturated salt water (5 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>), to obtain 150 mg of a yellowish solid 3-acetyl-4-methoxypyridine-2(1H)-one (yield: <semantics>67.6%<annotation encoding="application / x-tex">67.6\%< / annotation>< / semantics>). LC-MS: RT = <semantics>1.93<annotation encoding="application / x-tex">1.93< / annotation>< / semantics> min, [M+H]+= 168.01. At step B, 3-(2-hydroxypropane-2-yl)-4-methoxypyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, MeMgBr (0.90 ml, 2.69 mmol, 3 mol / ml) is added to the THF solution (4.0 ml) containing 3-acetyl-4-methoxypyridine-2(1H)-one (150 mg, 0.90 mmol), for reaction for 1h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (5ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3times); an organic phase is combined; washing is performed with saturated salt water (5 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane <semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics> 1 / 0), to obtain 65 mg of a yellowish solid 3-(2-hydroxypropane-2-yl)-4-methoxypyridine-2(1H)-one (yield: 39.6%).LC-MS: RT = 1.95 <semantics>min⁡M[M+H]+=184.12.<annotation encoding="application / x-tex">\min_{M} [M+H] + = 184.12.< / annotation>< / semantics> At step C, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-4-methoxy-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, a 1,4-dioxane solution (4.0) ml) containing 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (82 mg, 0.18 mmol), 3-(2-hydroxypropane-2-yl)-4-methoxypyridine-2(1H)-one (58 mg, 0.32 mmol), K2CO3 (50 mg, 0.36 mmol), CuI (7 mg, 0.036 mmol) and dimethylethylenediamine (6 mg, 0.072 mmol) is degassed, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; filtrate is concentrated. Residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>). 75 mg of a yellowish solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-4-methoxy-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 75%). LC-MS: RT = 1.88 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 559.19. 1H NMR (400 MHz, DMSO) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics>8.67 (s, 1H), 8.59 <semantics>(d,J=2.4Hz,1H),8.10−8.06(m,1H),8.00(d,J=7.9Hz,1H),7.75(s,1H),7.59(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),6.78(s,1H),<annotation encoding="application / x-tex">(d, J = 2.4 Hz, 1H), 8.10-8.06 (m, 1H), 8.00 (d, J = 7.9 Hz, 1H), 7.75 (s, 1H), 7.59 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H), 6.78 (s, 1H),< / annotation>< / semantics> 1H), <semantics>6.60<annotation encoding="application / x-tex">6.60< / annotation>< / semantics> (d, <semantics>J=8.0<annotation encoding="application / x-tex">J = 8.0< / annotation>< / semantics> Hz, 1H), <semantics>5.47<annotation encoding="application / x-tex">5.47< / annotation>< / semantics> (d, <semantics>J=2.0<annotation encoding="application / x-tex">J = 2.0< / annotation>< / semantics> Hz, 2H), <semantics>3.91<annotation encoding="application / x-tex">3.91< / annotation>< / semantics> (s, 3H), <semantics>2.07<annotation encoding="application / x-tex">2.07< / annotation>< / semantics> (s, 3H), <semantics>1.99<annotation encoding="application / x-tex">1.99< / annotation>< / semantics> (s, 3H), 1.46 (s, 3H), 1.43 (s, 3H). Embodiment 32 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 32 is prepared by means of the following method. At step A, 3-acetyl-5-bromopyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 40 degrees Celsius, a THF solution (1.0 ml, 2.0 mol / l) of MeMgBr is slowly added dropwise into the THF (4.0) ml) containing 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (199.0 mg, 1.0 mmol), for reaction for 2h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched by adding a diluted hydrochloric acid aqueous solution (4.0 ml, 1.0 mol / l); pH is adjusted to be neutral by using a saturated sodium bicarbonate solution; extraction is performed with dichloromethane (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); drying is performed with anhydrous sodium sulfate, and then concentration is performed; and obtained residues are directly used for next reaction. LC-MS: <semantics>RT=1.57min<annotation encoding="application / x-tex">RT = 1.57min< / annotation>< / semantics>, <semantics>[M+H]+=216.02<annotation encoding="application / x-tex">[M+H]^+ = 216.02< / annotation>< / semantics>. At step B, 5-bromo-3-(2-hydroxypropane-2-yl)pyridine-2-(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 40 degrees Celsius, the THF solution (1.0 ml, 2.0 mol / l) of MeMgBr is slowly added dropwise into the THF (4.0 ml) containing 3-acetyl-5-bromopyridine-2(1H)-one (216.0 mg, 1.0 mmol), for reaction for 2h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched by adding a diluted hydrochloric acid aqueous solution (4.0 ml, 1.0 mol / l); pH is adjusted to be neutral by using a saturated sodium bicarbonate solution; extraction is performed with dichloromethane (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 2 / 1). 150 mg of a white solid 5-bromo-3-(2-hydroxypropane-2-yl)pyridine-2-(1H)-one is obtained (yield: 64.7%). LC-MS: RT <semantics>=1.63min,[M+H]+=234.08.<annotation encoding="application / x-tex">= 1.63 \text{min}, [M+H]^+ = 234.08.< / annotation>< / semantics> At step C, 5-bromo-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-di methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, the 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (137 mg, 0.30 mmol), 5-bromo-3-(2-hydroxypropane-2-yl)pyridine-2(1H)-one (141.5 mg, 0.61 mmol), CuI (12 mg, 0.06 mmol), and K2CO3 (84 mg, 0.61 mmol) are dissolved in the dioxane (4 ml), a drop of dimethylethylenediamine is added, and then the temperature is warmed up to 100 degrees Celsius for microwave reaction for 1h under nitrogen protection. After the reaction is completed, filter is performed; filtrate is concentrated; and obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 0<annotation encoding="application / x-tex">1 / 0< / annotation>< / semantics>). 129.6 mg of a white solid 5-bromo-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-di methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 71.1%). LC-MS: <semantics>RT=1.97 min<annotation encoding="application / x-tex">RT = 1.97 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=609.14<annotation encoding="application / x-tex">[M+H]^+ = 609.14< / annotation>< / semantics>. Nuclear magnetic resonance data: 1H NMR (400) MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), 8.59 (d, J = 2.3 Hz, 1H), 8.14-8.04 (m, 2H), 7.77 (s, 1H), 7.72 <semantics>(d,J=2.8 Hz,1H),6.78 (s, 1H),5.47 (d, J=1.5 Hz,2H),5.28 (s, 1H),2.07 (s, 3H),1.98 (s, 3H),<annotation encoding="application / x-tex">(d, J = 2.8 \text{ Hz}, 1H), 6.78 \text{ (s, 1H)}, 5.47 \text{ (d, } J = 1.5 \text{ Hz}, 2H), 5.28 \text{ (s, 1H)}, 2.07 \text{ (s, 3H)}, 1.98 \text{ (s, 3H)},< / annotation>< / semantics> <semantics>1.45<annotation encoding="application / x-tex">1.45< / annotation>< / semantics> (d, <semantics>J=4.0<annotation encoding="application / x-tex">J = 4.0< / annotation>< / semantics> Hz, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>). Embodiment 33 [Image disponible dans le document PDF, Image available in the PDF document] A compound with a serial number being 33 is prepared by means of the following method. At step A, 3-acetyl-5-chloropyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, NCS (500 mg, 3.67 mmol) is added to N,N-DMF (5 ml) containing 3-acetylpyridine-2(1H)-one (500 mg, 3.67 mmol), for reaction for 3h by warming up the temperature to 80 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = 10 / 1). 300 mg of a yellowish solid 3-acetyl-5-chloropyridine-2(1H)-one is obtained (yield: 54%). LC-MS: RT = 1.68 min, [M+H]+ <semantics>=172.07.<annotation encoding="application / x-tex">= 172.07.< / annotation>< / semantics> At step B, 3-(2-hydroxypropane-2-yl)-5-chloropyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 78 degrees Celsius, a THF solution (3 ml, 1 mol / ml) of MeMgBr is added dropwiseinto the THF (20 ml) containing 3-acetyl-5-chloropyridine-2(1H)-one (300 mg, 1.75 mmol), for reaction for 3h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with a mixed solution of dichloromethane and isopropanol (dichloromethane / isopropanol=3 / 1, 30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 5 times); an organic phase is combined; washing is performed with saturated salt water <semantics>(30 ml×2 times)<annotation encoding="application / x-tex">(30 \text{ ml} \times 2 \text{ times})< / annotation>< / semantics>; and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol <semantics>=<annotation encoding="application / x-tex">=< / annotation>< / semantics> 10 / 1). 150 mg of a white solid 3-(2-hydroxypropane-2-yl)-5-chloropyridine-2(1H)-one is obtained (yield: 46%). LC-MS: RT = <semantics>1.59 min,[M+H]+=188.10.<annotation encoding="application / x-tex">1.59 \text{ min}, [M+H]^+ = 188.10.< / annotation>< / semantics> At step C, 3",5-dichloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl -2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (80 mg, 0.18 mmol), 3-(2-hydroxypropane-2-yl)-5-chloropyridine-2(1H)-one (33 mg, 0.18 mmol), CuI (7 mg, 0.04 mmol), and K2CO3 (48 mg, 0.35 mmol) are dissolved in the dioxane (4 ml), and a drop of dimethylethylenediamine is added, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, filter is performed; drip washing is performed with ethyl acetate, and filtrate is concentrated; and the obtained crude product is prepared with high performance liquid phase to obtain 50 mg of a white solid 3",5-dichloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl -2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone (yield: 51%). LC-MS: RT = 1.93 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 563.18. 1H NMR (400 MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.67 (s, 1H), <semantics>8.59 (d, J=2.3 Hz, 1H),8.14−8.01 (m, 2H),7.78 (s, 1H),7.65 (d, J=3.0 Hz, 1H),6.78 (s, 1H),<annotation encoding="application / x-tex">8.59 \text{ (d, J} = 2.3 \text{ Hz, 1H)}, 8.14-8.01 \text{ (m, 2H)}, 7.78 \text{ (s, 1H)}, 7.65 \text{ (d, J} = 3.0 \text{ Hz, 1H)}, 6.78 \text{ (s, 1H)},< / annotation>< / semantics> <semantics>5.47<annotation encoding="application / x-tex">5.47< / annotation>< / semantics> (d, <semantics>J=1.4<annotation encoding="application / x-tex">J = 1.4< / annotation>< / semantics> Hz, <semantics>2H<annotation encoding="application / x-tex">2H< / annotation>< / semantics>), <semantics>5.29<annotation encoding="application / x-tex">5.29< / annotation>< / semantics> (s, <semantics>1H<annotation encoding="application / x-tex">1H< / annotation>< / semantics>), <semantics>2.07<annotation encoding="application / x-tex">2.07< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.98<annotation encoding="application / x-tex">1.98< / annotation>< / semantics> (s, <semantics>3H<annotation encoding="application / x-tex">3H< / annotation>< / semantics>), <semantics>1.50−1.42<annotation encoding="application / x-tex">1.50-1.42< / annotation>< / semantics> (m, <semantics>6H<annotation encoding="application / x-tex">6H< / annotation>< / semantics>). Embodiment 34 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 34 is shown as follows. At step A, 3-acetyl-6-methylpyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 78 degrees Celsius, a THF solution (5.47 ml, 1 mol / ml) of MeMgBr is added dropwise into the THF (20 ml) containing 6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (500 mg, 3.73 mmol), for reaction for 3h by slowly warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with a mixed solution of dichloromethane and isopropanol (dichloromethane / isopropanol=3 / 1, <semantics>30 ml×5 times<annotation encoding="application / x-tex">30 \text{ ml} \times 5 \text{ times}< / annotation>< / semantics>); an organic phase is combined; washing is performed with saturated salt water <semantics>(30 ml×2 times)<annotation encoding="application / x-tex">(30 \text{ ml} \times 2 \text{ times})< / annotation>< / semantics>; and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = <semantics>10 / 1<annotation encoding="application / x-tex">10 / 1< / annotation>< / semantics>), to obtain 300 mg of a yellowish solid 3-acetyl-6-methylpyridine-2(1H)-one (yield: <semantics>53%<annotation encoding="application / x-tex">53\%< / annotation>< / semantics>). LC-MS: RT = 1.29 min, [M+H]+ = 152.15. At step B, 3-(2-hydroxypropane-2-yl)-6-methylpyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 78 degrees Celsius, a THF solution (3 ml, 1 mol / ml) of MeMgBr is added dropwise into the THF (20 ml) containing 3-acetyl-6-methylpyridine-2(1H)-one (300 mg, 1.98 mmol), for reaction for 3h by warming up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with a mixed solution of dichloromethane and isopropanol (dichloromethane / isopropanol=3 / 1, 30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 5 times); an organic phase is combined; washing is performed with saturated salt water (30 ml × 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane / methanol = 10 / 1). 200 mg of a white solid 3-(2-hydroxypropane-2-yl)-6-methylpyridine-2(1H)-one is obtained (yield: 60%). LC-MS: RT = <semantics>1.52 min,[M+H]+=168.20.<annotation encoding="application / x-tex">1.52 \text{ min}, [M+H]^+ = 168.20.< / annotation>< / semantics> At step C, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6,6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] A , 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (80 mg, 0.18 mmol), 3-(2-hydroxypropane-2-yl)-6-methylpyridine-2(1H)-one (30 mg, 0.18 mmol), CuI (7 mg, 0.04 mmol), and K2CO3 (48 mg, 0.35 mmol) are dissolved in the dioxane (4 ml), and a drop of dimethylethylenediamine is added, for microwave reaction for 1h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, filter is performed; drip washing is performed with ethyl acetate, and filtrate is concentrated; and the obtained crude product is prepared with high performance liquid phase to obtain 2.49 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6,6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone (yield: 3%). LC-MS: RT = <semantics>1.88 min<annotation encoding="application / x-tex">1.88 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=543.18<annotation encoding="application / x-tex">[M+H]^+ = 543.18< / annotation>< / semantics>. Embodiment 35 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 35 is shown as follows. At step Α, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5,5',6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, trimethylboroxine (0.02) ml, 0.16 mmol), [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium (1.17 mg, 0.0016 mmol) and Na2CO3 (33.9 mg, 0.32 mmol) are added to a mixed solvent (2.0 ml, toluene / water=3 / 1) containing 5-bromo-3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-di methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone (100 mg, 0.16 mmol), for reaction for 2h by warming up the temperature to 90 degrees Celsius under nitrogen protection. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml × 2 times); and drying is performed with anhydrous sodium sulfate, and then concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 15.4 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5,5',6"-trimethyl- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 17.8%). LC-MS: RT = <semantics>1.89 min<annotation encoding="application / x-tex">1.89 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=543.25<annotation encoding="application / x-tex">[M+H]^+ = 543.25< / annotation>< / semantics>. Embodiment 36 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 36 is shown as follows. At step A, 3-(bromomethyl)-2-methoxypyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (5.65 g, 21.56 mmol) and CBr4 (5.72 g, 17.24 mmol) are added to dichloromethane (30.0 ml) containing (2-methoxypyridine-3-yl)methanol (2.0 g, 14.37 mmol) for reaction for 1h at room temperature. After reaction is completed, vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane). 2.95 g of yellow colorless oil 3-(bromomethyl)-2-methoxypyridine is obtained (yield: 97.7%). LCMS: RT = 1.97 min, [M+H]+ <semantics>=202.03.<annotation encoding="application / x-tex">= 202.03.< / annotation>< / semantics> At step B, 2-(2-methoxypyridine-3-yl)acetonitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, trimethylsilyl cyanide (3.60 ml, 28.68 mmol) and a THF solution <semantics>(28.7 ml,1.0 mol / l) of<annotation encoding="application / x-tex">(28.7 \text{ ml}, 1.0 \text{ mol / l}) \text{ of}< / annotation>< / semantics> tetrabutylammonium fluoride are added to acetonitrile (30.0 ml) containing 3-(bromomethyl)-2-methoxypyridine (2.9 g, 14.34 mmol), for reaction for 1h at 80 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane). 1.90 g of a white solid 2-(2-methoxypyridine-3-yl)acetonitrile is obtained (yield: 88.82%). LCMS: RT = 1.73 min, <semantics>[M+H]+=149.17.<annotation encoding="application / x-tex">[M+H]^+ = 149.17.< / annotation>< / semantics> At step C, 2-(2-methoxypyridine-3-yl)-2-methylpropionitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, THF (5.0 ml) containing 2-(2-methoxypyridine-3-yl)acetonitrile (1.90 g, 0.013 mmol) is added to THF (15.0 ml) containing sodium hydride (2.0 g, 0.05 mmol, 60% of which being dispersed in paraffin oil), for reaction for 2h at room temperature; and CH3I is added, to continue the reaction overnight. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane). 2.17 g of colourless liquid 2-(2-methoxypyridine-3-yl)-2-methylpropionitrile is obtained (yield: 94.2%). LCMS: RT = 1.89 min, <semantics>[M+H]+=177.11<annotation encoding="application / x-tex">[M+H]^+ = 177.11< / annotation>< / semantics>. At step D, 2-(2-methoxypyridine-3-yl)-2-methylpropanal is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At minus 78 degrees Celsius, a toluene solution (12.15 ml, 1.5 mol / l) of dissobutylaluminium hydride is added to dichloromethane (200.0 ml) containing 2-(2-methoxypyridine-3-yl)-2-methylpropionitrile (2.17 g, 12.23 mmol), for reaction by warm up the temperature to room temperature. After the reaction is completed, the reaction is quenched with water; dichloromethane is evaporated; diluted hydrochloric acid is added to stir for 30 min; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane). 1.56 g of colourless liquid 2-(2-methoxypyridine-3-yl)-2-methylpropanal is obtained (yield: 70.9%). LCMS: RT = 1.91 min, <semantics>[M+H]+=180.16.<annotation encoding="application / x-tex">[M+H]^+ = 180.16.< / annotation>< / semantics> At step E, 3-(1,1-difluoro-2-methylpropane-2-yl)-2-methoxypyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, diethylaminosulfurtrifluoride (2.13 ml, 17.34 mol / l) is added to dichloromethane (20.0 ml) containing 2-(2-methoxypyridine-3-yl)-2-methylpropanal (1.56 g, 8.67 mmol), for reaction at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with dichloromethane (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane). 700.0 mg of colourless liquid 3-(1,1-difluoro-2-methylpropane-2-yl)-2-methoxypyridine is obtained (yield: 40.0%). LCMS: <semantics>RT=2.05 min,[M+H]+=202.15.<annotation encoding="application / x-tex">RT = 2.05 \text{ min}, [M+H]^+ = 202.15.< / annotation>< / semantics> At step F, 3-(1,1-difluoro-2-methylpropane-2-yl)pyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, sodium iodide (780.7 mg, 5.2 mmol) and chlorotrimethylsilane (660.0 μL, 5.2 mmol) are added to acetonitrile (7.0) ml) containing 3-(1,1-difluoro-2-methylpropane-2-yl)-2-methoxypyridine (700.0 mg, 3.47 mmol), for reaction at 65 degrees Celsius. After the reaction is completed, the reaction is quenched with water; pH is adjusted to 8 with saturated sodium carbonate; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: methanol / dichloromethane = <semantics>1 / 20<annotation encoding="application / x-tex">1 / 20< / annotation>< / semantics>). 533.0 mg of yellow colorless oil 3-(1,1-difluoro-2-methylpropane-2-yl)pyridine-2(1H)-one is obtained (yield: 81.6%). LCMS: RT <semantics>=1.68 min,[M+H]+=188.16.<annotation encoding="application / x-tex">= 1.68 \text{ min}, [M+H]^{+} = 188.16.< / annotation>< / semantics> At step G, 3"-chloro-3-(1,1-difluoro-2-methylpropane-2-yl)-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, the 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (100.0 mg, 0.22 mmol), 3-(1,1-difluoro-2-methylpropane-2-yl)pyridine-2(1H)-one (49.6 mg, 0.26 mmol), CuI (9.5 mg, 0.05 mmol), and K2CO3 (60.7 mg, 0.44 mmol) are dissolved in the dioxane (2.0 ml), and a drop of N,N-dimethylethylenediamine is added, for microwave reaction for 1h at 80 degrees Celsius. After the reaction is completed, suction filtration is performed; a filter cake is washed with dichloromethane; and vacuum concentration is performed on filtrate. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate). 28.0 mg of a white solid 3"-chloro-3-(1,1-difluoro-2-methylpropane-2-yl)-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-d imethyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 22.6%). LCMS: RT = 1.99 min, <semantics>[M+H]+=563.17<annotation encoding="application / x-tex">[M+H]^+ = 563.17< / annotation>< / semantics>. Embodiment 37 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 37 is shown as follows. At step A, 2-chloro-5-cyclopropylpyridine-4-amine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, a 1,4-dioxane solution (20.0) ml) containing 2-chloro-5-iodo-4-pyridinamine (1.0 g, 3.93 mmol), cyclopropylboronic acid (0.68 g, 7.86 mmol), [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium (290 mg, 0.39 mmol) and K2CO3 (1.09 g, 7.86 mmol) is warmed up to 100°C for reaction for 24h. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 5<annotation encoding="application / x-tex">1 / 5< / annotation>< / semantics>), to obtain 580 mg of 2-chloro-5-cyclopropylpyridine-4-amine (yield: 87.6%). LCMS: RT = 0.7 min, [M+H]+ = 169.09. At step B, 2'-chloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (760 mg, 4.13) mmol) is added to 1,4-dioxane (10.0 ml) containing 2-chloro-5-cyclopropylpyridine-4-amine (580 mg, 3.44 mmol), for reaction for 2h by warming up the temperature to 90°C. Then, a sulfuric acid solution (1.5 ml, 10 mol / l) is added dropwise, to continue to react for 2h at 90°C. After the reaction is completed, the temperature is cooled to room temperature; a solid is precipitated by adding water, and filter is performed; drip washing is performed with water for 2 times; and then decompression drying is performed, to obtain 550 mg of a yellowish solid 2'-chloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 57.8%). LCMS: RT = 1.70 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 277.12. At step C, 2',3-dichloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,2-dichloroethane (2.5 ml), NCS (159 mg, 1.19 mmol) and dichloroacetic acid (1 drop) are added to isopropanol (5.0 ml) containing 2'-chloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (300 mg, 1.08 mmol); and the mixed solution is warmed up to 65 degrees Celsius for reaction for 1h. After the reaction is completed, the reaction is quenched by adding water (1.0 ml); a solvent is removed under reduced pressure; ethyl acetate is added to the obtained residues for pulping, and then filter is performed; and decompression drying is performed, to obtain 230 mg of a yellowish solid 2',3-dichloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: <semantics>68.2%<annotation encoding="application / x-tex">68.2\%< / annotation>< / semantics>). LCMS: RT = 1.73 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 311.10. At step D, 2',3-dichloro-5'-cyclopropyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl ]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (136 mg, 0.66 mmol) and K2CO3 (151 mg, 1.01 mmol) are added to an N,N-DMF solution (2.0 ml) containing 2',3-dichloro-5'-cyclopropyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (170 mg, 0.55) mmol) for reaction for 1h at room temperature. After the reaction is completed, water (10.0 ml) is added, and then a solid is precipitated; filter is performed, and drip washing is performed with water for two times; and decompression drying is performed, to obtain 180 mg of a yellowish solid 2',3-dichloro-5'-cyclopropyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl ]-2-one is obtained (yield: 75%). LCMS: <semantics>RT=1.96 min<annotation encoding="application / x-tex">RT = 1.96 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=438.13<annotation encoding="application / x-tex">[M+H]^+ = 438.13< / annotation>< / semantics>. At step E, 3"-chloro-5'-cyclopropyl-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6" -methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,4-dioxane (5.0) ml) containing 2',3-dichloro-5'-cyclopropyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl ]-2-one (180 mg, 0.41 mmol), 3-(2-hydroxypropane-2-yl)-pyridine-2(1H)-one (75 mg, 0.49 mmol), K2CO3 (114 mg, 0.82 mmol), CuI (16 mg, 0.082 mmol) and dimethylethylenediamine (15 mg, 0.16 mmol) is degassed, for microwave reaction for 2h at 110 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; and vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate). 16 mg of a yellowish solid $3"-chloro-5'-cyclopropyl-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6"$ -methyl-2H,2"H-<Formule mathématique disponible dans le document PDF, Math available in the PDF document>$[1,2':4',1"$-terpyridine<semantics>]<annotation encoding="application / x-tex">]< / annotation>< / semantics>-2,2"-diketone is obtained (yield: 7%). LCMS: RT = 1.89min, <semantics>[M+H]+=555.22<annotation encoding="application / x-tex">[M+H]^+ = 555.22< / annotation>< / semantics>. H NMR (400 MHz, DMSO-d6) <semantics>δ<annotation encoding="application / x-tex">\delta< / annotation>< / semantics> 8.59 (d, J = 2.4 Hz, 1H), 8.40 (s, 1H), <semantics>8.14−8.01<annotation encoding="application / x-tex">8.14-8.01< / annotation>< / semantics> (m, 1H), <semantics>7.82<annotation encoding="application / x-tex">7.82< / annotation>< / semantics> (dd, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics>, <semantics>2.0<annotation encoding="application / x-tex">2.0< / annotation>< / semantics> Hz, 1H), <semantics>7.75<annotation encoding="application / x-tex">7.75< / annotation>< / semantics> (s, 1H), <semantics>7.68<annotation encoding="application / x-tex">7.68< / annotation>< / semantics> (dd, <semantics>J=7.1<annotation encoding="application / x-tex">J = 7.1< / annotation>< / semantics>, <semantics>2.1<annotation encoding="application / x-tex">2.1< / annotation>< / semantics> Hz, 1H), <semantics>6.80<annotation encoding="application / x-tex">6.80< / annotation>< / semantics> (s, 1H), <semantics>6.40<annotation encoding="application / x-tex">6.40< / annotation>< / semantics> (t, <semantics>J=6.9<annotation encoding="application / x-tex">J = 6.9< / annotation>< / semantics> Hz, 1H), <semantics>5.47<annotation encoding="application / x-tex">5.47< / annotation>< / semantics> (s, 2H), <semantics>5.22<annotation encoding="application / x-tex">5.22< / annotation>< / semantics> (s, 1H), <semantics>2.02<annotation encoding="application / x-tex">2.02< / annotation>< / semantics> (s, 3H), <semantics>1.54−1.47<annotation encoding="application / x-tex">1.54-1.47< / annotation>< / semantics> (m, 1H), 1.46 (s, 3H), 1.44 (s, 3H), 1.06–1.00 (m, 1H), 0.89 (m, 2H), 0.72-0.67 (m, 1H). Embodiment 38 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 38 is shown as follows. At step A, 2-methyl-2-(2-oxo-1,2-dihydropyridine-3-yl)propionitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, sodium iodide (255.0 mg, 1.7 mmol) and chlorotrimethylsilane (215.0 μL, 1.7 mmol) are added to acetonitrile (3.0) ml) containing 2-(2-methoxypyridine-3-yl)-2-methylpropionitrile (200.0 mg, 1.13 mmol), for reaction by warming up the temperature to 65 degrees Celsius. After the reaction is completed, the reaction is quenched with water; pH is adjusted to 8 with saturated sodium carbonate; extraction is performed with ethyl acetate (30 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: methanol / dichloromethane = 1 / 20). 170.0 mg of yellow colorless oil 2-methyl-2-(2-oxo-1,2-dihydropyridine-3-yl)propionitrile is obtained (92.3%). LCMS: RT = 1.56 min, <semantics>[M+H]+=163.13<annotation encoding="application / x-tex">[M+H]^+ = 163.13< / annotation>< / semantics>. At step В, 2-(3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-2,2"-diketone-2H,2"H-[1,2': 4',1"-terpyridine]-3-yl)-2-methylpropionitrile is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (100.0 mg, 0.22 mmol), 2-methyl-2-(2-oxo-1,2-dihydropyridine-3-yl)propionitrile (42.6 mg, 0.26 mmol), CuI (9.5 mg, 0.05 mmol), and K2CO3 (60.7 mg, 0.44 mmol) are dissolved in dioxane (2.0 ml), and a drop of N,N-dimethylethylenediamine is added, for microwave reaction for 1h at 80 degrees Celsius. After the reaction is completed, suction filtration is performed; drip washing is performed with dichloromethane; and vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate). 37.0 mg of a white solid 2-(3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-2,2"-diketone-2H,2"H-[1,2': 4',1"-terpyridine]-3-yl)-2-methylpropionitrile is obtained (yield: 31.2%). LCMS: RT = 1.91 min, <semantics>[M+H]+=538.20.<annotation encoding="application / x-tex">[M+H]^+ = 538.20.< / annotation>< / semantics> Embodiment 39 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 39 is shown as follows. At step A, 2'-chloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (700 mg, 3.78) mmol) is added to 1,4-dioxane (10.0 ml) containing 2-chloro-4-amino-5-methoxypyridine (500 mg, 3.15 mmol), for reaction for 2h by warming up the temperature to 90degrees Celsius. Then, a sulfuric acid solution (1.2 ml, 10 mol / l) is added dropwise, to continue to react for 2h at 90degrees Celsius. After the reaction is completed, the temperature is cooled to room temperature; a solid is precipitated by adding water, and filter is performed; drip washing is performed with water for 2 times; and then decompression drying is performed, to obtain 540 mg of a yellowish solid 2'-chloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 64.3%). LCMS: <semantics>RT=1.66 min,[M+H]+=267.04.<annotation encoding="application / x-tex">RT = 1.66 \text{ min}, [M+H]^+ = 267.04.< / annotation>< / semantics> At step B, 2',3-dichloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,2-dichloroethane (3.0 ml), NCS (297 mg, 2.23 mmol) and dichloroacetic acid (3 drops) are added to isopropanol (6.0 ml) containing 2'-chloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one (540 mg, 2.02 mmol), for reaction for 1h by warming up the temperature to 65 degrees Celsius. After the reaction is completed, the reaction is quenched by adding water (1.0 ml); a solvent is removed under reduced pressure; pulping is performed by adding ethyl acetate, and then filter is performed; and decompression drying is performed, to obtain 450 mg of a yellowish solid 2',3-dichloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 73.9%). LCMS: RT = 1.68 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 301.09. At step C, 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2 -one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (180 mg, 0.87 mmol) and K2CO3(200 mg, 1.44 mmol) are added to an N,N-DMF solution (3.0 ml) containing 2',3-dichloro-4-hydroxyl-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2-one (217 mg, 0.72 mmol), for reaction for 1h at room temperature. After the reaction is completed, water (10.0 ml) is added, and then a solid is precipitated; filter is performed, and drip washing is performed with water for two times; and decompression drying is performed, to obtain 220 mg of a yellowish solid 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2 -one is obtained (yield: 71.4%). LCMS: <semantics>RT=1.89 min<annotation encoding="application / x-tex">RT = 1.89 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=428.07<annotation encoding="application / x-tex">[M+H]^+ = 428.07< / annotation>< / semantics>. At step D, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5'-methoxy-6"-me thyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,4-dioxane (5.0) ml) containing 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-methoxy-6-methyl-2H-[1,4'-bipyridyl]-2 -one (220 mg, 0.51 mmol), 3-(2-hydroxypropane-2-yl)-pyridine-2(1H)-one (118 mg, 0.77 mmol), K2CO3 (132 mg, 1.02 mmol), CuI (49 mg, 0.26 mmol) and dimethylethylenediamine (46 mg, 0.51 mmol) is degassed, for microwave reaction for 2h at 110 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; and vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate). 22 mg of a yellowish solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5'-methoxy-6"-me thyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 7.8%). LCMS: RT = 1.86 min, <semantics>[M+H]+=545.21<annotation encoding="application / x-tex">[M+H]^+ = 545.21< / annotation>< / semantics>. Embodiment 40 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 40 is shown as follows. At step A, 3-bromo-2-((4-methoxybenzyl)oxy)pyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 4-methoxybenzyl alcohol (1.5 g, 11.0 mmol) and potassium tert-butoxide (1.34 g, 12.0 mmol) are added to 1,4-dioxane (30.0 ml) containing 3-bromo-2-chloropyridine (1.92 g, 10.0 mmol), for reaction for 2h by warming up the temperature to 100 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (50 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (50 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 8). 2.85 g of yellow colorless oil 3-bromo-2-((4-methoxybenzyl)oxy)pyridine is obtained (yield: <semantics>97.3%<annotation encoding="application / x-tex">97.3\%< / annotation>< / semantics>). LCMS: RT = <semantics>2.18<annotation encoding="application / x-tex">2.18< / annotation>< / semantics> min, <semantics>[M+H]+=294.05.<annotation encoding="application / x-tex">[M+H]^+ = 294.05.< / annotation>< / semantics> At step В, 3-(3,6-dihydro-2H-pyran-4-yl)-2-((4-methoxybenzyl)oxy)pyridine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, tetrakis(triphenylphosphine)palladium (115.6 mg, 0.1 mmol) and Na2CO3(270 mg, 2.5 mmol) are added to a mixed solvent solution (4.0 ml, 1,4-dioxane / water = 3 / 1) containing 3-bromo-2-((4-methoxybenzyl)oxy)pyridine (293.0 mg, 1.0 mmol) and 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester (252.0 mg, 1.2 mmol), for reaction for 12h by warming up the temperature to 100 degrees Celsius under nitrogen protection. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 8). 194 mg of a yellow solid 3-(3,6-dihydro-2H-pyran-4-yl)-2-((4-methoxybenzyl)oxy)pyridine is obtained (yield: 65.3%). LCMS: <semantics>RT=2.14 min,[M+H]+=298.24.<annotation encoding="application / x-tex">RT = 2.14 \text{ min}, [M+H]^+ = 298.24.< / annotation>< / semantics> At step C, 3-(tetrahydro-2H-pyran-4-yl)pyridine-2(1H)-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, wet palladium carbon (125.8 mg, 0.065 mmol) is added to a mixed solvent solution (4.0) ml, methanol / ethyl acetate = 2 / 1) containing 3-(3,6-dihydro-2H-pyran-4-yl)-2-((4-methoxybenzyl)oxy)pyridine (194.0 mg, 0.65 mmol); and hydrogen replacement is performed for three times, for reaction for 12h by warming up the temperature to 40 degrees Celsius under hydrogen atmosphere. After the reaction is completed, filter is performed, and then concentration is performed. The obtained yellowish solid 3-(tetrahydro-2H-pyran-4-yl)pyridine-2(1H)-one is directly used for a next step. LCMS: <semantics>RT=1.50 min<annotation encoding="application / x-tex">RT = 1.50 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=180.15<annotation encoding="application / x-tex">[M+H]^+ = 180.15< / annotation>< / semantics>. At step C, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-3-(tetrahydro-2H-pyran-4-yl)- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-bromo-3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-o ne (137 mg, 0.30 mmol), 3-(tetrahydro-2H-pyran-4-yl)pyridine-2(1H)-one (109.2 mg, 0.61 mmol), CuI (12 mg, 0.06 mmol), and K2CO3 (84 mg, 0.61 mmol) are dissolved in the dioxane (4.0 ml); and dimethylethylenediamine (one drop) is added, for microwave reaction for 40 min at 80 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; concentration is performed; and purification is performed by silica gel column chromatography (eluent: ethyl acetate). 115.3 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5',6"-dimethyl-3-(tetrahydro-2H-pyran-4-yl)- 2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 69.4%). LCMS: RT = 1.86 min, <semantics>[M+H]+=555.23.<annotation encoding="application / x-tex">[M+H]^+ = 555.23.< / annotation>< / semantics> Embodiment 41 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 41 is shown as follows. At step Α, 2',3-dibromo-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, N-bromosuccinimide (77 mg, 0.65 mmol) and dichloroacetic acid (1 drop) are added to isopropanol (3.0) ml) containing 2'-bromo-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (250) mg, 0.59 mmol), for reaction for 1h by warming up the temperature to 65 degrees Celsius. After the reaction is completed, the temperature is cooled to room temperature; filter is performed; and decompression drying is performed, to obtain 230 mg of a white solid 2',3-dibromo-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 77.2%). LCMS: <semantics>RT=1.93 min<annotation encoding="application / x-tex">RT = 1.93 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=501.99<annotation encoding="application / x-tex">[M+H]^+ = 501.99< / annotation>< / semantics>. At step В, 3"-bromo-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H ,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,4-dioxane (2.0) ml) containing 2',3-dibromo-4-((3,5-difluoropyridine-2-yl)methoxy)-5',6-dimethyl-2H-[1,4'-bipyridyl]-2-one (100 mg, 0.20 mmol), 3-(2-hydroxypropane-2-yl)-pyridine-2(1H)-one (37 mg, 0.24 mmol), K2CO3 (55 mg, 0.40 mmol), CuI (8 mg, 0.04 mmol) and dimethylethylenediamine (7 mg, 0.08 mmol) is degassed, for microwave reaction for 1h at 80 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; and concentration is performed. Purification is performed by silica gel column chromatography (eluent: ethyl acetate). 47 mg of a white solid 3"-bromo-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H ,2''H-[1,2':4',1''-terpyridine]-2,2''-diketone is obtained (yield: 41.2%). LCMS: RT = 1.87 min, <semantics>[M+H]+=575.11.<annotation encoding="application / x-tex">[M+H]^+ = 575.11.< / annotation>< / semantics> Embodiment 42 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 42 is shown as follows. At step A, 2-chloro-5-ethylpyridine-4-amine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] A mixed solution (20.0 ml, 1,4-dioxane:water =4:1) of 1,4-dioxane containing 2-chloro-5-iodo-4-pyridinamine (1.5 g, 5.9 mmol), ethylboronic acid (871.1 mg, 11.8 mmol), [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium (431.2 mg, 0.6 mmol) and K2CO3 (1.6 g, 11.8 mmol) and water is warmed up to 100 degrees Celsius for reaction for 24h. After the reaction is completed, drip washing is performed by adding water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (20 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 5<annotation encoding="application / x-tex">1 / 5< / annotation>< / semantics>), to obtain 410.0 mg of a yellowish solid 2-chloro-5-ethylpyridine-4-amine (yield: <semantics>44.5%<annotation encoding="application / x-tex">44.5\%< / annotation>< / semantics>). LCMS: RT = <semantics>0.47<annotation encoding="application / x-tex">0.47< / annotation>< / semantics> min, [M+H]+ = 157.09. At step B, 2'-chloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (574.6 mg, 3.1 mmol) is added to 1,4-dioxane (10.0 ml) containing 2-chloro-5-ethylpyridine-4-amine (410.0 mg, 2.6 mmol), for reaction for 2h by warming up the temperature to 90degrees Celsius. Then, a sulfuric acid solution (1.5 ml, 10 mol / l) is added dropwise, to continue to react for 2h at 90degrees Celsius. After the reaction is completed, the temperature is cooled to room temperature; a solid is precipitated by adding water, and filter is performed; drip washing is performed with water for 2 times; and then decompression drying is performed, to obtain 180.0 mg of a yellowish solid 2'-chloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 26.2%). LCMS: <semantics>RT=1.70 min,[M+H]+=265.13.<annotation encoding="application / x-tex">RT = 1.70 \text{ min}, [M+H]^+ = 265.13.< / annotation>< / semantics> At step C, 2',3-dichloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,2-dichloroethane (2.5 ml), NCS (100.1 mg, 0.7 mmol) and dichloroacetic acid (1 drop) are added to isopropanol (5.0 ml) containing 2'-chloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (180.0 mg, 0.7 mmol); and the mixed solution is warmed up to 65 degrees Celsius for reaction for 1h. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (10 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>4 / 1<annotation encoding="application / x-tex">4 / 1< / annotation>< / semantics>), to obtain 230.0 mg of a yellowish solid (crude product) 2',3-dichloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one. LCMS: <semantics>RT=1.74 min,[M+H]+=299.12.<annotation encoding="application / x-tex">RT = 1.74 \text{ min}, [M+H]^+ = 299.12.< / annotation>< / semantics> At step D, 2',3-dichloro-5'-ethyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl]-2-on e is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (176.2 mg, 0.8 mmol) and K2CO3 (212.5 mg, 1.5 mmol) are added to an N,N-DMF solution (2.0 ml) containing 2',3-dichloro-5'-ethyl-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (230.0 mg, 0.8 mmol), for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (10 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>4 / 1<annotation encoding="application / x-tex">4 / 1< / annotation>< / semantics>), to obtain 91.0 mg of a yellowish solid 2',3-dichloro-5'-ethyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl]-2-on e (yield: 27.7%). LCMS: <semantics>RT=1.95 min<annotation encoding="application / x-tex">RT = 1.95 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=426.12<annotation encoding="application / x-tex">[M+H]^+ = 426.12< / annotation>< / semantics>. At step E, 3"-chloro-5'-ethyl-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6"-methy 1-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,4-dioxane (5.0) ml) containing 2',3-dichloro-5'-ethyl-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-2H-[1,4'-bipyridyl]-2-on e (71.0 mg, 0.61 mmol), 3-(2-hydroxypropane-2-yl)-pyridine-2(1H)-one (38.3 mg, 0.25 mmol), K2CO3 (146.1 mg, 0.3 mmol), CuI (15.8 mg, 0.08 mmol) and dimethylethylenediamine (15 mg, 0.16 mmol) is degassed, for microwave reaction for 2h at 110 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; and concentration is performed. Preparation and separation are performed with a high performance liquid phase, to obtain 3.0 mg of a white solid 3"-chloro-5'-ethyl-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6"-methy 1-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 3.3%). LCMS: RT = 1.91 min, <semantics>[M+H]+=543.20.<annotation encoding="application / x-tex">[M+H]^+ = 543.20.< / annotation>< / semantics> Embodiment 43 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 43 is shown as follows. At step Α, 3"-chloro-4"-((2,4,6-trifluorophenyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2 ':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,4,6-trifluorobenzyl bromide (45 mg, 0.20 mmol) and K2CO3 (55 mg, 0.40 mmol) are added to N,N-DMF (3 ml) containing 3"-chloro-4"-((2,4,6-trifluorophenyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2 ':4',1"-terpyridine]-2,2"-diketone (80 mg, 0.20 mmol), for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate). 21 mg of a white solid 3"-chloro-4"-((2,4,6-trifluorophenyl)oxy)-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2 ':4',1"-terpyridine]-2,2"-diketone is obtained (yield: <semantics>25%<annotation encoding="application / x-tex">25\%< / annotation>< / semantics>). LCMS: RT = 1.97 min, [M+H]+ = 546.21. Embodiment 44 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 44 is shown as follows. At step A, 1-(bromomethyl)-2,3,4-trifluorobenzene is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At zero degrees Celsius, PPh3 (813.5 mg, 3.11 mmol) and CBr4 (823.8 mg, 2.48 mmol) are added to THF (5.0 ml) containing the (2,3,4-trifluorophenyl)methanol (335.4 mg, 2.07 mmol), for reaction for 1h at room temperature. After reaction is completed, vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 10 / 1). 388.0 mg of colorless oil 1-(bromomethyl)-2,3,4-trifluorobenzene is obtained (yield: 73.2%). LCMS: RT = 2.11 min. At step В, 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((2,3,4-trifluorophenyl)oxy)-2H,2"H-[1,2 ':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1-(bromomethyl)-2,3,4-trifluorobenzene (40.2 mg, 0.18 mmol) and K2CO3 (33.12 mg, 0.24 mmol) are added to N,N-DMF (2.0 ml) containing 3"-chloro-4"-hydroxyl-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-2H,2"H-[1,2':4',1"-terpyridine] -2,2"-diketone (50.0 mg, 0.12 mmol), for reaction for 2h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 1 / 0). 35.2 mg of a white solid 3"-chloro-3-(2-hydroxypropane-2-yl)-5',6"-dimethyl-4"-((2,3,4-trifluorophenyl)oxy)-2H,2"H-[1,2] ':4',1"-terpyridine]-2,2"-diketone is obtained (yield: <semantics>53.7%<annotation encoding="application / x-tex">53.7\%< / annotation>< / semantics>). LCMS: RT = 1.98 min, [M+H]+ = 546.20. Embodiment 45 [Image disponible dans le document PDF, Image available in the PDF document] A synthetic route of a compound with a serial number being 45 is shown as follows. At step A, 6-chloro-4-((4-methoxybenzyl)amino)methyl nicotinate is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, methyl 4,6-dichloronicotinate (7.0 g, 33.9 mmol), 4-methoxybenzylamine (5.6 g, 40.8 mmol) and triethylamine (4.1 g, 40.8 mmol) are dissolved in acetonitrile (60.0 ml), for reaction for 12h at room temperature. After the reaction is completed, concentration is performed, and water is added; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (20 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>1 / 3<annotation encoding="application / x-tex">1 / 3< / annotation>< / semantics>), to obtain 9.3 g of a white solid 6-chloro-4-((4-methoxybenzyl)amino)methyl nicotinate (yield: 89.6%). LCMS: RT = 2.07 min, <semantics>[M+H]+=307.13.<annotation encoding="application / x-tex">[M+H]^+ = 307.13.< / annotation>< / semantics> At step B, (6-chloro-4-((4-methoxybenzyl)amino)pyridin-3-yl)methanol is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 6-chloro-4-((4-methoxybenzyl)amino)methyl nicotinate (9.3 g, 30.3 mmol) is dissolved in THF (90.0 ml); at zero degrees Celsius, lithium aluminum hydride (1.7 g, 45.5 mmol) is added in batches, for reaction for 30 min by warming up the temperature to room temperature. After the reaction is completed, 1.7 ml of water and 1.7 ml of 15% sodium hydroxide aqueous solution are added under an ice bath; suction filtration; and concentration is performed to obtain 5.0 g of a white solid (6-chloro-4-((4-methoxybenzyl)amino)pyridin-3-yl)methanol (yield: <semantics>60.0%<annotation encoding="application / x-tex">60.0\%< / annotation>< / semantics>). LCMS: RT = 1.73 min, <semantics>[M+H]+=1279.16<annotation encoding="application / x-tex">[M+H]^+ = 1279.16< / annotation>< / semantics>. At step C, 2-chloro-5-(fluoromethyl)-N-(4-methoxybenzyl)pyridin-4-amine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, (6-chloro-4-((4-methoxybenzyl)amino)pyridin-3-yl)methanol (5.0 g, 18.0 mmol) is dissolved in dichloromethane (100.0 ml); the temperature is cooled below zero degrees Celsius; diethylaminosulfurtrifluoride (4.3 g, 27.0 mmol) is added dropwise; after the diethylaminosulfurtrifluoride is added, reaction is performed for 30 min at zero degrees Celsius. After the reaction is completed, reactant is poured into a saturated sodium bicarbonate aqueous solution; extraction is performed with dichloromethane (30 ml × 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: dichloromethane), to obtain 930.0 mg of yellowish liquid 2-chloro-5-(fluoromethyl)-N-(4-methoxybenzyl)pyridin-4-amine (yield: 18.4%). LCMS: RT = 1.93 min, <semantics>[M+H]+=281.17<annotation encoding="application / x-tex">[M+H]^+ = 281.17< / annotation>< / semantics>. At step D, 2-chloro-5-(fluoromethyl)pyridin-4-amine is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-chloro-5-(fluoromethyl)-N-(4-methoxybenzyl)pyridin-4-amine (930.0 mg, 3.3 mmol) is dissolved in dichloromethane (10.0 ml); the temperature is cooled below zero degrees Celsius; methanesulfonic acid (1.0 ml) is added dropwise; after the methanesulfonic acid is added, reaction is performed for 2h at room temperature. After the reaction is completed, the reaction solution is slowly poured into the saturated sodium bicarbonate aqueous solution; extraction is performed with dichloromethane (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; drying is performed with anhydrous sodium sulfate; and vacuum concentration is performed, to obtain 393.0 mg of a yellowish solid 2-chloro-5-(fluoromethyl)pyridin-4-amine (yield: <semantics>44.5%<annotation encoding="application / x-tex">44.5\%< / annotation>< / semantics>). LCMS: RT = <semantics>0.47<annotation encoding="application / x-tex">0.47< / annotation>< / semantics> min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 161.08. At step E, 2'-chloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (542.9 mg, 2.9 mmol) is added to 1,4-dioxane (10.0 ml) containing 2-chloro-5-(fluoromethyl)pyridin-4-amine (393.0 mg, 2.4 mmol), for reaction for 2h by warming up the temperature to 90degrees Celsius. Then, a sulfuric acid solution (1.0 ml, 10 mol / l) is added dropwise, to continue to react for 2h at 90degrees Celsius. After the reaction is completed, the temperature is cooled to room temperature; a solid is precipitated by adding water, and filter is performed; drip washing is performed with water for 2 times; and then decompression drying is performed, to obtain 163.0 mg of a yellowish solid 2'-chloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 25.3%). LCMS: RT = 1.68 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 269.12. At step F, 2',3-dichloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,2-dichloroethane (2.5 ml), NCS (78.4 mg, 0.6 mmol) and dichloroacetic acid (1 drop) are added to isopropanol (5.0 ml) containing 2'-chloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (143.0 mg, 0.5) mmol), for reaction for 1h by warming up the temperature to 65 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 4 times); an organic phase is combined; washing is performed with saturated salt water (10 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>4 / 1<annotation encoding="application / x-tex">4 / 1< / annotation>< / semantics>), to obtain 23.0 mg of a yellowish solid 2',3-dichloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (yield: 15.2%). LCMS: <semantics>RT=1.68 min,[M+H]+=303.07.<annotation encoding="application / x-tex">RT = 1.68 \text{ min}, [M+H]^+ = 303.07.< / annotation>< / semantics> At step G, 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-(fluoromethyl)-6-methyl-2H-[1,4'-bipyri dyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (19.0 mg, 0.09 mmol) and K2CO3 (20.9 mg, 0.15 mmol) are added to an N,N-DMF solution (5.0 ml) containing 2',3-dichloro-5'-(fluoromethyl)-4-hydroxyl-6-methyl-2H-[1,4'-bipyridyl]-2-one (23.0 mg, 0.07) mmol), for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (10 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (10 ml); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Obtained residues are purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = <semantics>6 / 1<annotation encoding="application / x-tex">6 / 1< / annotation>< / semantics>), to obtain 15.0 mg of a yellow solid 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-(fluoromethyl)-6-methyl-2H-[1,4'-bipyri dyl]-2-one (yield: <semantics>49.9%<annotation encoding="application / x-tex">49.9\%< / annotation>< / semantics>). LCMS: RT = 1.91 min, [M+H]+ = <semantics>430.09<annotation encoding="application / x-tex">430.09< / annotation>< / semantics>. At step Η, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5'-(fluoromethyl)-3-(2-hydroxypropane-2-yl)- 6"-methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 1,4-dioxane (5.0) ml) containing 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-5'-(fluoromethyl)-6-methyl-2H-[1,4'-bipyri dyl]-2-one (15.0 mg, 0.035 mmol), 3-(2-hydroxypropane-2-yl)-pyridine-2(1H)-one (8.0 mg, <semantics>0.052 mmol<annotation encoding="application / x-tex">0.052 \text{ mmol}< / annotation>< / semantics>), <semantics>K2CO3<annotation encoding="application / x-tex">K_2CO_3< / annotation>< / semantics> (9.6 mg, 0.07 mmol), CuI (3.3 mg, 0.0175 mmol) and dimethylethylenediamine (15 mg, 0.16 mmol) is degassed, for microwave reaction for 1h at 100 degrees Celsius under nitrogen protection. After the reaction is completed, filter is performed; and concentration is performed. Preparation and separation are performed with a high performance liquid phase, to obtain 0.5 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-5'-(fluoromethyl)-3-(2-hydroxypropane-2-yl)- 6"-methyl-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is obtained (yield: 2.6%). LCMS: RT = 1.86 min, <semantics>[M+H]+=547.20<annotation encoding="application / x-tex">[M+H]^+ = 547.20< / annotation>< / semantics>. Embodiment 46 [Image disponible dans le document PDF, Image available in the PDF document] 95 A synthetic route of a compound with a serial number being 46 is shown as follows. At step A, 2'-chloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-chloro-5-trifluoromethylpyridine-4-amine (1.55 g, 7.6 mmol) is dissolved into dioxane (20 ml), 2,2-dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one (1.4 g, 7.6 mmol) is further added, for reaction for 5h by warming up the temperature to 90 degrees Celsius; and then, 10N of a sulfuric acid aqueous solution is further added dropwise until no solid is produced, and the reaction is continued for 2h. After the reaction is complete, concentration is performed; a yellowish precipitate is precipitated by adding water; filtering is performed after 0.5h of stirring, and drip washing is performed with water for two times; and 1 g of an earth-yellow solid 2'-chloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one is obtained (yield: 43%). LCMS: RT = 1.75 min, <semantics>[M+H]+<annotation encoding="application / x-tex">[M+H]^+< / annotation>< / semantics> = 305.04. At step C, 2',3-dichloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2'-chloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one (1 g, 3.28 mmol) is dissolved in isopropanol (30 ml); NCS (540 mg, 3.28 mmol) is further added; and then dichloroacetic acid (1 drop) is added, for reaction for 6h by warming up the temperature to 60 degrees Celsius. After the reaction is completed, the reaction is quenched with water; extraction is then performed with ethyl acetate; an organic phase is combined; drying is performed with anhydrous sodium sulfate; filter is performed, and then concentration is performed; and purification (ethyl- acetate) is performed through column chromatography to obtain 900 mg of a white solid 2',3-dichloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one (yield: 82%). LCMS: <semantics>RT=1.78 min<annotation encoding="application / x-tex">RT = 1.78 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=338.99<annotation encoding="application / x-tex">[M+H]^+ = 338.99< / annotation>< / semantics>. At step В, 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bip yridyl]-2-one is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] At room temperature, 2-(bromomethyl)-3,5-difluoropyridine (185 mg, 0.89 mmol) and K2CO3 (246 mg, 1.78 mmol) are added to N,N-DMF solution (3 ml) containing 2',3-dichloro-4-hydroxyl-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bipyridyl]-2-one (300 mg, 0.89 mmol), for reaction for 1h at room temperature. After the reaction is completed, the reaction is quenched with water; extraction is performed with ethyl acetate (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 3 times); an organic phase is combined; washing is performed with saturated salt water (20 ml <semantics>×<annotation encoding="application / x-tex">\times< / annotation>< / semantics> 2 times); and drying is performed with anhydrous sodium sulfate, and then vacuum concentration is performed. Purification is performed by silica gel column chromatography (eluent: ethyl acetate). 150 mg of a white solid 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bip yridyl]-2-one is obtained (yield: 36%). LCMS: <semantics>RT=1.98 min<annotation encoding="application / x-tex">RT = 1.98 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=466.04<annotation encoding="application / x-tex">[M+H]^+ = 466.04< / annotation>< / semantics>. At step Ε, 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6"-methyl-5'-(trifl uoromethyl)-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone is synthesized. [Image disponible dans le document PDF, Image available in the PDF document] : At room temperature, 2',3-dichloro-4-((3,5-difluoropyridine-2-yl)methoxy)-6-methyl-5'-(trifluoromethyl)-2H-[1,4'-bip yridyl]-2-one (50 mg, 0.11 mmol) CuI (6 mg, 0.02 mmol) and K2CO3 (61 mg, 0.22 mmol) are dissolved in dioxane (4 ml), and dimethylethylenediamine (one drop) is further added, for microwave reaction for 1h at 80 degrees Celsius. After the reaction is completed, filter is performed; drip washing is performed with ethyl acetate; concentration is performed; and purification is performed through column chromatography, to obtain 1 mg of a white solid 3"-chloro-4"-((3,5-difluoropyridine-2-yl)methoxy)-3-(2-hydroxypropane-2-yl)-6"-methyl-5'-(trifl uoromethyl)-2H,2"H-[1,2':4',1"-terpyridine]-2,2"-diketone. LCMS: <semantics>RT=1.97 min<annotation encoding="application / x-tex">RT = 1.97 \text{ min}< / annotation>< / semantics>, <semantics>[M+H]+=1.97 min<annotation encoding="application / x-tex">[M+H]^+ = 1.97 \text{ min}< / annotation>< / semantics> 583.20. Comparative example 1 A structure of the compound 3-chloro-4-((3,5-difluoropyridine-2-yl)methoxy)-2'-(2-(2-hydroxypropane-2-yl)pyrimidin-4-yl-5' ,6-dimethyl-2H-[1,4'-bipyridyl]-2-one is shown as follows. [Image disponible dans le document PDF, Image available in the PDF document] For the synthetic route of the compound in Comparative example 1, refer to a synthetic route of a compound of which Chinese Patent Application No. is CN201480032278.5 and specification serial number is 49. Supercritical fluid chromatography (OD-H column) is used to separate a racemic Comparative example 1 compound by means of a mobile phase of carbon dioxide and ethanol, and atropisomer Comparative example 1A and 1B compounds are eluted successively. [Image disponible dans le document PDF, Image available in the PDF document] (-) Comparative example 1A (+) Comparative example 1B Comparative example 1A compound: <semantics>RT=4.47 min (SFC, OD-H, 0.46 cm I.D.×15 cm L<annotation encoding="application / x-tex">RT = 4.47 \text{ min (SFC, OD-H, } 0.46 \text{ cm I.D.} \times 15 \text{ cm L}< / annotation>< / semantics> column, isogradient method with 40% ethanol, flow rate being 2.5 mL / min, and cycling time being 10 min); and [a]D25-0.66 °(MeOH, Rudolph Autopol I specific rotation instrument). Comparative example 1B compound: <semantics>RT=4.68 min (SFC, OD-H, 0.46 cm I.D.×15 cm L<annotation encoding="application / x-tex">RT = 4.68 \text{ min (SFC, OD-H, } 0.46 \text{ cm I.D.} \times 15 \text{ cm L}< / annotation>< / semantics> column, isogradient method with 40% ethanol, flow rate being 2.5 mL / min, and cycling time being 10 min). [a]D25+0.68°(MeOH, Rudolph Autopol I specific rotation instrument). Embodiment 47: an experiment of releasing TNFα from U937 induced by LPS Cytokine regulation in human monocytes has shown that the p38 pathway is the key to the biosynthesis of a plurality of pro-inflammatory cytokines including TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, IL-1<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics> and IL-6. Therefore, the inhibition of the p38 MAPK pathway is to reduce inflammatory response by reducing the biosynthesis of the pro-inflammatory cytokines. This research shows half amount of the compound in the present invention required to inhibit the biosynthesis of <semantics>TNFα<annotation encoding="application / x-tex">TNF\alpha< / annotation>< / semantics> (pro-inflammatory cytokine). This is a reflection of the effect of the compound in the present invention to facilitate reduction of inflammation, which is useful in the treatment of various diseases, including chronic inflammatory diseases, acute inflammatory diseases, or self-inflammatory diseases. The potency and efficacy of the p38 inhibitor in blocking cytokine production are evaluated using a human U937 cell line. Reagents and instruments: A 1640 medium with an article number being A10491-01, Gibco; penicillin-streptomycin with an article number being 15140-122, Gibco; fetal bovine serum with an article number being 10099-141C, Gibco; PBS with an article number being 10010-031, Gibco; LPS with an article number being L2880, Sigma; PMA with an article number being P1585, Sigma; dimethyl sulfoxide with an article number being D8418-1L, Sigma; and a TNFα kit with an article number being K151QWD-4, MSD. A 96-well plate with an article number being 3599, Corning; a plate-vibrating device with an article number being QB-9002, QILINBEIER; a centrifuge with an article number being 5810R, Eppendorf; a carbon dioxide incubator with an article number being 371, Thermo; a counter with an article number being C10281, Gibco; a microscope with an article number being CKX41, OLYMPUS; and an MSD plate reader with an article number being 1201MESO SECTOR 600, MSD. Experimental cells: U937, ATCC with an article number being CRL-1593.2. Drug preparation: About 2 mg of a drug is weighted; a mother solution is prepared to 10 mM (which is calculated by free alkali) by means of DMSO; and the mother solution is diluted 10-fold to 1 mM, and then is successively diluted 4-fold to 250 μM, 62.5 μM, 15.6 μM, 3.9 μM, 0.97 μM, 0.24 µM, and 0.061 µM. The above series of diluted DMSO drugs is diluted 20-fold as working solutions by using media. Experimental method: At Day 0, 10000 / well inoculation is performed, stimulation is performed for 48h with 20 ng / ml of PMA, and culture is performed at 37°C, 5%CO2. At Day 2, 1. Supernatant is removed from differentiated U937, cleaning is performed once with PBS, and 96 μl of the 1640 medium is added. 2. 2 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>l of the compound containing (DMSO with a final concentration being 0.1%), and culture is performed for 30 min at 37°C, 5%CO2. 3. 2µl of LPS (a final concentration being 100ng / ml) is added, cells are stimulated, and culture is performed for 4h at 37°C, 5%CO2. 4. Centrifugation is performed, supernatant is taken, and content of TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics> in the supernatant is determined through ELISA. Statistical method: The content of TNFα corresponding to each well is calculated by using a standard curve in the kit. The compound IC50 is calculated by using a GraphPad nonlinear fitting formula, and for an experimental result, refer to Table 1. Table 1 IC50 value that the compound of the present invention inhibits the production of TNFα [Image disponible dans le document PDF, Image available in the PDF document] From the experimental results of Table 1, it may be learned that, the compound of the present invention has an obvious inhibitory activity on the production of TNF<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>, so that related diseases such as inflammatory response may be regulated. Embodiment 48: Determination of solubility. 1. Preparation of a control solution About 0.5 mg of a to-be-tested sample in a centrifuge tube is weighted, an appropriate amount of DMSO is added to completely dissolve the sample, and then methanol is added to make up to 1 ml. The to-be-tested sample is the compound with the serial number being 1 and the compound in Comparative example 1. 2. Preparation of a test solution About 1.0 mg of each of the compound in Comparative example 1 and the compound with the serial number being 1 is weighed into two centrifuge tubes, and 1 ml of buffer solutions of PBS=2.0 and 7.4 are added to the two tubes, respectively. (If there are more pH values to be investigated, the preparation method may be deduced by analogy). 3. The prepared control solution and test solution are simultaneously put into a 37°C water bath and heated for 1h, after 1h, the solutions are taken out and cooled to room temperature, and then the solutions are filtered with a 0.22 µm filter membrane for sample injection. 4. The concentration of the sample in the test solution is calculated according to <semantics>C=(A*(ms / vs)) / AS<annotation encoding="application / x-tex">C=(A*(ms / vs)) / AS< / annotation>< / semantics>, and experiment results are shown in Table 2. Note: ms, vs and AS are the weight, volume and peak area of the sample in the control solution, respectively. A is the peak area of the test solution. Table 2 Solubility of the compound of the present invention [Image disponible dans le document PDF, Image available in the PDF document] From the experiment results of Table 2, it may be learned that, compounds with serial numbers being 1, 2, 3 and 20 in this application have desirable solubility, and are superior to those of the compound in Comparative example 1. Embodiment 49: Pharmacokinetic experiment 1. Reagents and instruments Polyethylene glycol 400 (batch number: GORKREUT, Saen Chemical Technology (Shanghai) Co., Ltd.); DMSO (batch number: 20200319, GHTECH (Guangdong) Co., Ltd.); and normal saline (batch number: C20052604, Jiangxi Kelun Pharmaceutical Co., Ltd.). An LC-MS instrument (Thermo Fisher Ultimate 3000 UPLC, TSQ QUANTUM ULTRA® TSQ Quantum GC). 2. Experimental animals 5 male Beagle dogs with weights being 5 kg to 7 kg, purchased from Beijing Mars Biotechnology Co., Ltd. 3. Preparations Test powder is accurately weighted, and is completely dissolved with DMSO, then PEG-400 is added; vortex and ultrasonic mixing are performed; then the normal saline is added for vortex and ultrasonic mixing to make the mixture to 0.5 mg / mL (DMSO:PEG-400:NS=5:60:35, V / V / V); and 5 mL / kg is given through intragastric administration, and 1 mL / kg is given through intravenous administration. 4. Blood sample collection After the above mixture is given to the dogs through intragastric administration (n=3) or intravenous administration (n=2), about 1 mL of blood is collected from the forelimb or hindlimb vein with a scalp needle, respectively, at 5 min (intravenous administration only), 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 8 h, 24 h to put into blood collection tubes containing EDTA-K2 anticoagulant; centrifugation is performed for 10 min at 4000 rpm to separate plasma; and then the tubes are stored at -80°C for testing. 5. Bioanalysis A certain amount of a test sample is accurately weighted and dissolved with DMSO to 2 mg / mL, as a stock solution. The stock solution is diluted to 30000, 10000, 3000, 1000, 300, 1000, 50, 30, and 10 ng / mL by using acetonitrile:water (1:1), to obtain standard curve working solutions. 5 µL of the working solution is added to 45 µL of blank canine plasma; and well mixing is performed through vortex, to prepare into standard curve samples equivalent to plasma concentrations of 3000, 1000, 300, 100, 30, 10, 5, 3, and 1 ng / mL. 30 µL of the standard curve sample and the collected plasma sample (plasma collected at 5min, 15min, and 30min of intravenous administration is diluted 5-fold) are added to 150 µL of a propranolol acetonitrile solution (internal standard, 50 ng / mL) to precipitate protein, then 100 µL of water is added to well mix through vortex; centrifugation is performed for 5 min at 4000 rpm; and supernatant is taken for LC-MS analysis. LC-MS detection conditions include the following. Chromatographic column: Waters ACQUITYTM PREMIER HSS T3, 50*2.1mm, 1.8µm. Mobile phase A: water (0.1% formic acid); mobile phase B: acetonitrile; flow rate: 0.5 mL / min; and gradient elution is shown in Table 3 below. Table 3 [Image disponible dans le document PDF, Image available in the PDF document] 6. Data Processing After LC-MS detection of blood drug concentration, and a non-compartment model of WinNonlin 6.1 software is adopted to calculate pharmacokinetic parameters of beagle dogs after administration. Results are shown in Table 4 below. Table 4 Pharmacokinetic parameters in dogs of the compound of the present invention (IV and PO administration) [Image disponible dans le document PDF, Image available in the PDF document] From the experiment results of Table 4, it may be learned that, compared with the compound of Comparative example 1, the canine PK of the compound of the present invention with the serial number being 1 has higher oral exposure and bioavailability. Embodiment 50: p38a / MK2 complex kinase screening experiment Table 5 Reagent: [Image disponible dans le document PDF, Image available in the PDF document] Table 6 Instrument: [Image disponible dans le document PDF, Image available in the PDF document] Drug preparation: A certain amount of a drug is weighted and prepared into a 10 mM of mother solution by using DMSO; the mother solution is diluted to 100 µM (100X working solution) in two steps; and then, the solution is diluted 3-fold to 33.33 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 11.11 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 3.70 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 1.23 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 0.41 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 0.14 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 0.046 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, 0.015 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, and 0.005 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M, successively. DMSO control is also arranged. Then, a series of diluted DMSO drugs are diluted 25 folds with 1X IMAP Reaction Buffer as a 4X drug working solution. Experimental method: a), the 1X IMAP Reaction Buffer is used to prepare an enzyme (MEK6, active), p38α (unactive), MK2(unactive), a substrate (HSP27) and ATP. b), 10 µL of a 2X enzyme &substrate working solution and 5 µL of a 4X drug working solution are successively added in a black 384-well plate; and after rapid centrifugation, 5 µL of an ATP working solution is added to start enzymatic reaction. 10 gradient concentrations and 2 duplicated wells are set to each group of compounds; and a DMSO control group and a negative control group (DMSO, no ATP) are additionally set. The final concentration of each component is shown in Table 7 below. Table7 [Image disponible dans le document PDF, Image available in the PDF document] c), after 1h of incubation at room temperature, 1X Progressive Binding Solution is added to end the enzymatic reaction; after 30 min of incubation, a BMGPHERASTER FSX multifunctional microplate reader is used to detect a Fluorescence Polarization (FP) signal [FP(Ex485 / Em520 / Em520nm)]. Statistical method: A GraphPad Prism 7 nonlinear fitting formula is used to calculate the compound IC50, and results are shown in Table 8. Table 8: IC50 value that the compound of the present invention inhibits p38α / MK2 complex [Image disponible dans le document PDF, Image available in the PDF document] From the experimental results of Table 8, it may be learned that, the compound of the present invention has an obvious inhibitory activity on p38α / MK2 complex, so that related diseases such as inflammatory response may be regulated. Embodiment 51: p38α kinase screening experiment Table 9 Reagent: [Image disponible dans le document PDF, Image available in the PDF document] Table 10 Instrument: [Image disponible dans le document PDF, Image available in the PDF document] Drug preparation: A certain amount of the compound is weighed, prepared into a 10 / 50 mM mother solution with DMSO, diluted 3 folds with DMSO, and diluted to 10 concentration points as a compound working solution. Experimental method: 50 nL of the diluted compound working solution is transferred to each well of a reaction plate (784075, Greiner) with Echo 655, then 2.5 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>L (4 ng / <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>L) of a p38<semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics> kinase solution is added; after 10 minutes at room temperature, 2.5 µL of a mixed solution of a kinase substrate (0.2 mg / mL) and ATP (150 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>M) is added, for reaction for 60 min at room temperature; and 4 <semantics>μ<annotation encoding="application / x-tex">\mu< / annotation>< / semantics>L of an ADP Glo reagent is added, for incubation for 40 min at room temperature. 8 µL of a kinase detection reagent is added, for incubation for 40 min at room temperature; and finally a light-emitting signal is read on Envision 2104. Data analysis A GraphPad Prism 8 nonlinear fitting formula is used to calculate the compound IC50, and test results are shown in Table 11. Table 11: IC50 value that the compound of the present invention inhibits <semantics>p38α<annotation encoding="application / x-tex">p38\alpha< / annotation>< / semantics> [Image disponible dans le document PDF, Image available in the PDF document] From the experiment results of Table 11, it may be learned that, compared with the prior art, the compound of the present invention has higher activity multiple relative to <semantics>p38α / (p38α / MK2)<annotation encoding="application / x-tex">p38\alpha / (p38\alpha / MK2)< / annotation>< / semantics> complex) and better selectivity. Note: p38α / MK2 complex kinase data is from Embodiment 50. Embodiment 52: p38β kinase screening experiment Table 12 Reagent: [Image disponible dans le document PDF, Image available in the PDF document] Table 13 Instrument: [Image disponible dans le document PDF, Image available in the PDF document] Drug preparation: A certain amount of the compound is weighed, prepared into a 10 / 50 mM mother solution with DMSO, diluted 3 folds with DMSO, and diluted to 10 concentration points as a compound working solution. Experimental method: 50 nL of the diluted compound working solution is transferred to each well of a reaction plate (784075, Greiner) with Echo 655, then 2.5 μL (2 ng / μL) of a p38β kinase solution is added; after 10 minutes at room temperature, 2.5 µL of a mixed solution of a kinase substrate (0.4 mg / mL) and ATP (100 μM) is added, for reaction for 60 min at room temperature; and 4 μL of an ADP Glo reagent is added, for incubation for 40 min at room temperature. 8 µL of a kinase detection reagent is added, for incubation for 40 min at room temperature; and finally a light-emitting signal is read on Envision 2104. Data analysis A GraphPad Prism 8 nonlinear fitting formula is used to calculate the compound IC50, and test results are shown in Table 14. Table 14: IC50 value that the compound of the present invention inhibits p38<semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics> [Image disponible dans le document PDF, Image available in the PDF document] From the experiment results of Table 14, it may be learned that, compared with the prior art, the compound of the present invention has higher activity multiple relative to <semantics>p38β / (p38α / MK2)<annotation encoding="application / x-tex">p38\beta / (p38\alpha / MK2)< / annotation>< / semantics> complex) and better selectivity. Note: p38α / MK2 complex kinase data is from Embodiment 50. The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principle of the present invention should be equivalent substitutions and are included within the protection scope of the present invention.

Claims

<pat:ClaimStatement>CLAIMS< / pat:ClaimStatement> <pat:Claims com:id="claims"> <pat:Claim com:id="CLM-00001"> <pat:ClaimNumber>1< / pat:ClaimNumber> <pat:ClaimText>1. A compound represented by general formula (I), or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein, R1 and R1 are independently selected from hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, alkyl heterocycloalkyl, phenyl, heteroaryl, haloalkyl, or cyano, or R1 and R1 are cyclized to the cycloalkyl or the heterocycloalkyl together; R2 is selected from hydrogen, halogen, hydroxyl, cyano, alkyl, alkoxy, alkoxyalkyl, or haloalkyl; R3 is independently selected from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, halogen, alkoxy, cyano, haloalkoxy, or sulfonyl; m is 0, 1, 2, or 3; R4 is selected from hydrogen, alkyl, cycloalkyl, alkoxy, or haloalkyl; R5 is selected from hydrogen, alkyl, cycloalkyl, alkoxy, or haloalkyl; R6 is selected from hydrogen, halogen, cyano, alkyl, cycloalkyl, or haloalkyl; ring A is selected from an aromatic ring or a heteroaromatic ring; R7 is independently selected from hydrogen, halogen, cyano, alkyl, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, or sulfonyl; n is 0, 1, 2, 3, 4, or 5; X is O, CH2 or NH; and R8 and R9 are independently selected from hydrogen, alkyl, cycloalkyl, alkylcycloalkyl, or haloalkyl, or R8 and R9 are cyclized to the cycloalkyl or the heterocycloalkyl together. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00002"> <pat:ClaimNumber>2< / pat:ClaimNumber> <pat:ClaimText>2. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein the alkyl is selected from <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkyl, and the <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkyl is selected from methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, sec-pentyl, 1-ethylpropyl, 2-methylbutyl, tert-pentyl, 1,2-dimethylpropyl, isopentyl, neopentyl, n-hexyl, isohexyl, sec-hexyl, tert-hexyl, neohexyl, 2-methylpentyl, 1,2-dimethylbutyl, or 1-ethylbutyl; and / or the alkoxy is selected from <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkoxy, and the <semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics> alkoxy is selected from methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentyloxy, sec-pentyloxy, 1-ethylpropoxy, 2-methylbutoxy, tert-pentyloxy, 1,2-dimethylpropoxy, isopentyloxy, neopentyloxy, n-hexyloxy, isohexyloxy, sec-hexyloxy, tert-hexyloxy, neohexyloxy, 2-methylpentyloxy, 1,2-dimethylbutoxy, or 1-ethylbutoxy; and alkoxyalkyl is selected from C1-4alkoxy-C1-4alkyl, and the C1-4alkoxy-C1-4alkyl is further selected from methoxymethyl, methoxyethyl, methoxypropyl, methoxybutyl, ethoxymethyl, ethoxyethyl, ethoxypropyl, ethoxybutyl, propoxymethyl, propoxyethyl, propoxypropyl, propoxybutyl, butoxymethyl, butoxyethyl, butoxypropyl, or butoxybutyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00003"> <pat:ClaimNumber>3< / pat:ClaimNumber> <pat:ClaimText>3. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein the cycloalkyl is selected from <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl, and the <semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics> cycloalkyl is selected from cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00004"> <pat:ClaimNumber>4< / pat:ClaimNumber> <pat:ClaimText>4. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein the aromatic ring is selected from a four-membered ring, a fused ring containing the four-membered ring, a five-membered ring, a fused ring containing the five-membered ring, a six-membered ring, a fused ring containing the six-membered ring, a biphenyl type aromatic ring; and the heteroaromatic ring means that one or more carbon atoms on the aromatic ring are substituted by a heteroatom. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00005"> <pat:ClaimNumber>5< / pat:ClaimNumber> <pat:ClaimText>5. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein the halogen is selected from fluorine, chlorine, bromine, or iodine; the haloalkyl means that one or more hydrogen atoms on the alkyl are substituted by the halogen; the haloalkoxy means that one or more hydrogen atoms on the alkoxy are substituted by the halogen; and the heterocycloalkyl means that one or more carbon atoms on the cycloalkyl are substituted by a heteroatom; and the alkylcycloalkylmeans that one or more hydrogen atoms on the cycloalkyl are substituted by an alkyl, and the alkylheterocycloalkylmeans that one or more hydrogen atoms on the heterocycloalkyl are substituted by an alkyl. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00006"> <pat:ClaimNumber>6< / pat:ClaimNumber> <pat:ClaimText>6. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein a heteroatom is selected from nitrogen, oxygen, or sulfur, and there are one or more heteroatoms. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00007"> <pat:ClaimNumber>7< / pat:ClaimNumber> <pat:ClaimText>7. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a [Image disponible dans le document PDF, Image available in the PDF document] pharmaceutically acceptable salt thereof, wherein the ring A is selected from [Image disponible dans le document PDF, Image available in the PDF document] < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00008"> <pat:ClaimNumber>8< / pat:ClaimNumber> <pat:ClaimText>8. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, selected from: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] wherein, m is 0, 1, 2, or 3; n is 0, 1, 2, 3, 4, or 5; <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>, <semantics>R1<annotation encoding="application / x-tex">R^1< / annotation>< / semantics>, <semantics>R2<annotation encoding="application / x-tex">R^2< / annotation>< / semantics>, <semantics>R3<annotation encoding="application / x-tex">R^3< / annotation>< / semantics>, <semantics>R4<annotation encoding="application / x-tex">R^4< / annotation>< / semantics>, <semantics>R5<annotation encoding="application / x-tex">R^5< / annotation>< / semantics>, <semantics>R6<annotation encoding="application / x-tex">R^6< / annotation>< / semantics>, <semantics>R7<annotation encoding="application / x-tex">R^7< / annotation>< / semantics>, <semantics>R8<annotation encoding="application / x-tex">R^8< / annotation>< / semantics>, and <semantics>R9<annotation encoding="application / x-tex">R^9< / annotation>< / semantics> are as defined in claim 1. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00009"> <pat:ClaimNumber>9< / pat:ClaimNumber> <pat:ClaimText>9. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein m is 0 or 1; n is 0, 1, or 2; [Image disponible dans le document PDF, Image available in the PDF document] the ring A is selected from or [Image disponible dans le document PDF, Image available in the PDF document] - R1 and R1 are selected from hydrogen, methyl, or ethyl, or R1 and R1 are cyclized to [Image disponible dans le document PDF, Image available in the PDF document] R2 is selected from hydrogen, hydroxyl, difluoromethyl, or cyano; R3 is selected from hydrogen, methyl, methoxy, chlorine, or bromine; R4 is selected from methyl, cyclopropyl, methoxy, ethyl, fluoromethyl, or trifluoromethyl; R5 is selected from methyl; R6 is selected from chlorine, hydrogen, or bromine; R7 is selected from hydrogen, fluorine, chlorine, bromine, cyclopropyl, methoxy, cyano, methyl, or trifluoromethyl; and R8 and R9 are hydrogen. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00010"> <pat:ClaimNumber>10< / pat:ClaimNumber> <pat:ClaimText>10. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, selected from: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] • < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00011"> <pat:ClaimNumber>11< / pat:ClaimNumber> <pat:ClaimText>11. The compound according to claim 1, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable salt refers to a salt prepared by the compound, or a racemate or a stereoisomeric isomer thereof, and a pharmaceutically acceptable acid or base. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00012"> <pat:ClaimNumber>12< / pat:ClaimNumber> <pat:ClaimText>12. A pharmaceutical composition for treating p38 / MK2 related diseases, comprising a therapeutically effective amount of the compound according to any one of claims 1 to 11, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00013"> <pat:ClaimNumber>13< / pat:ClaimNumber> <pat:ClaimText>13. Use of the compound according to any one of claims 1 to 11, or a racemate, or a stereoisomeric isomer, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for treating diseases, wherein the diseases are p38 / MK2 related diseases and selected from a chronic inflammatory disease and an acute inflammatory disease. < / pat:ClaimText> < / pat:Claim> <pat:Claim com:id="CLM-00014"> <pat:ClaimNumber>14< / pat:ClaimNumber> <pat:ClaimText>14. The use according to claim 13, wherein the chronic inflammatory disease is rheumatoid arthritis. < / pat:ClaimText> < / pat:Claim> < / pat:Claims>