Bicyclic fused heteroaromatic ring derivative, and pharmaceutical composition and use thereof

Abstract

Provided in the present application is a bifunctional compound as shown in formula (I). In addition, further disclosed in the present application are a pharmaceutically acceptable salt or a stereoisomer, a pharmaceutical composition and the use of the compound. The compound of the present application has a good degradation effect on EED, has a good inhibition effect on cell proliferation of tumor cells, and has a potential treatment effect on tumors. POI—(L) n0 —ULM (I)

Description

BICYCLIC FUSED HETEROAROMATIC RING DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF This application claims priorities to Chinese Patent Application No. 202311789109.3, titled 5 "BICYCLIC FUSED HETEROAROMATIC RING DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF" filed before the China National Intellectual Property Administration on December 22, 2023, and Chinese Patent Application No. 202410735064.X, titled "BICYCLIC FUSED HETEROAROMATIC RING DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF" filed before the China National Intellectual Property Administration on June 6, 2024, which are incorporated herein by reference in their entireties. TECHNICAL FIELD The present application relates to the field of pharmaceutical technology, and in particular, to a bicyclic fused heteroaromatic ring derivative, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a pharmaceutical composition thereof, and medical uses thereof. BACKGROUND The Polycomb group (PcG) protein Polycomb repressive complex 2 (PRC2) performs a core function of transcriptional repression in an organism, achieving gene silencing by catalyzing trimethylation of histone H3 at lysine 27 (H3K27me3). It can promote tumor initiation and progression by inhibiting the expression of tumor suppressor genes in tumors. The catalytic subunit of PRC2, EZH2, is an important representative of third-generation epigenetic regulation precision therapeutic targets. Compared to first-generation and second-generation pan-epigenetic regulation targets, current therapeutic targets can target tumors with specific mutation types, offering significantly improved efficacy and safety. Although EZH2 is an ideal target for directly shutting down aberrant PRC2 activity, PRC2 functions as a protein complex, whose activity and functionality are highly dependent on the 25 regulatory role of the scaffold and another core subunit, EED. Interfering with the protein-protein interaction (PPI) between EZH2 and EED can also inhibit the methyltransferase activity of the PRC2 complex. Novartis AG pioneered the demonstration through high-throughput screening that the H3K27me3 recognition pocket of EED is "druggable", and discovered that targeting EED can allosterically inhibit the catalytic activity of EZH2. The rise of targeted protein degradation (TPD) technology has provided a new pathway for small molecule drug development. Among these, proteolysis targeting chimeras (PROTACs) are the most well-developed system. Their mechanism of action involves linking a small molecule inhibitor and a ligand for an E3 ubiquitin ligase via a linker to form a targeted protein degradation chimera. In vivo, the inhibitor portion of this bifunctional molecule recognizes the target protein, while the E3 ligase ligand portion recognizes the ubiquitin ligase, ultimately degrading the target protein through the ubiquitin- proteasome pathway. Protein degradation drugs can target "undruggable" targets, improve selectivity and inhibitory activity against targets, and prolong drug duration of action and resistance to mutations. They are particularly suitable for drug development against traditionally undruggable targets (such as transcription factors and scaffold proteins), targets prone to acquired resistance mutations during tumor targeted therapy, targets with gene amplification and / or protein overexpression, targets with different protein isoforms, scaffold proteins, protein aggregates, etc. Currently, small molecule inhibitors targeting EZH2 have been approved for marketing, clinically validating the feasibility of PRC2 as an anti-tumor drug target. However, the efficacy of EZH2 small molecule inhibitors remains limited in solid tumors, and multiple small molecule inhibitors of EZH2 and EED are still under clinical investigation. Considering the structural and functional characteristics of PRC2 and the advantages of protein degradation drugs, utilizing protein degradation technology for drug development against this target may bring new directions and breakthroughs to the drug development for this target. Although a protein degrader of EED has been reported in the literature (Cell Chemical Biology 2020, 27: 41-46.), its degradation activity and druggability still have significant room for improvement. Therefore, there remains a need to develop highly active EED degraders for clinical research. SUMMARY The purpose of the present application is to provide a PROTAC compound. The compound of the present application is able to degrade and / or inhibit EED proteins, exhibits an excellent degradation / inhibition effect on EED protein and an excellent inhibition effect on tumor cell proliferation, has excellent pharmacokinetic properties, low toxic side effects, good safety, and is more suitable for treating diseases or conditions associated with aberrant EED protein activity (such as proliferative diseases like cancer). A first aspect of the present application provides a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] (I), wherein POI is a ligand that binds to an EED protein; L is a linker linking POI and ULM; ULM is a group that binds to an E3 ligase; and n0 is 0 or 1. In some embodiments, n0 is 0. In some embodiments, n0 is 1. In some embodiments, POI is a structure of formula (A-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(A−1)<annotation encoding="application / x-tex">(A-1)< / annotation>< / semantics>< / com:Math> wherein, ring A1 is a 5- to 20-membered heterocycloalkyl ring (preferably a 5- to 6-membered heterocycloalkyl ring, preferably a 15- to 20-membered heterocycloalkyl ring, more preferably a 15- to 18-membered heterocycloalkyl ring, further preferably an 18-membered heterocycloalkyl ring) or a 5- to 10-membered heteroaryl ring (preferably an 8- to 10-membered heteroaryl ring, more preferably a 9- membered heteroaryl ring, more preferably a 10-membered heteroaryl ring); ring A2 is absent, or is a 3- to 15-membered heterocycloalkyl ring, a C<com:Sub>3-10< / com:Sub> cycloalkylring, a 5- to 15-membered heteroaryl ring (preferably a 5- to 12-membered heteroaryl ring, more preferably a 5- to 10-membered heteroaryl ring, further preferably a 5- to 6-membered heteroaryl ring) or a <com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl ring (preferably a benzene ring or a naphthalene ring); <com:Math><semantics>(R1)n1<annotation encoding="application / x-tex">(R_1)_{n1}< / annotation>< / semantics>< / com:Math> represents substitution of hydrogen on 2,3-dihydrobenzofuran ring by n1 <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math>, n1 is 0, 1 or 2, each R<com:Sub>1< / com:Sub> is identical or different, and each R<com:Sub>1< / com:Sub> is independently selected from the group consisting of hydrogen, deuterium, halogen (preferably fluorine, chlorine or bromine), oxo, C<com:Sub>1-8< / com:Sub> alkyl (preferably C<com:Sub>1-< / com:Sub> 6 alkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkoxy), <com:Math><semantics>−COC1−8<annotation encoding="application / x-tex">-COC_{1-8}< / annotation>< / semantics>< / com:Math> alkyl (preferably <com:Math><semantics>−COC1−6<annotation encoding="application / x-tex">-COC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -OCOC<com:Sub>1-8< / com:Sub> alkyl (preferably -OCOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -OCOC<com:Sub>1-3< / com:Sub> alkyl), -COOC<com:Sub>1-8< / com:Sub> alkyl (preferably -COOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -COOC<com:Sub>1-3< / com:Sub> alkyl), -CONH<com:Sub>2< / com:Sub>, - CONHC<com:Sub>1-8< / com:Sub> alkyl (preferably -CONHC<com:Sub>1-6< / com:Sub> alkyl, more preferably -CONHC<com:Sub>1-3< / com:Sub> alkyl), -CON(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, more preferably -CON(<com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>), -SOC<com:Sub>1-8< / com:Sub> alkyl (preferably -SOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SOC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, more preferably - SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl (preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, more preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), - SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-8< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-3< / com:Sub> alkyl), - SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, more preferably -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>), C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 12-membered heterocycloalkyl (preferably 4- to 8-membered heterocycloalkyl, more preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6-membered heteroaryl) and <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl (preferably <com:Math><semantics>C6−12<annotation encoding="application / x-tex">C_{6-12}< / annotation>< / semantics>< / com:Math> aryl); and / or two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and carbon atom linked to the two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> together form a <com:Math><semantics>C3−15<annotation encoding="application / x-tex">C_{3-15}< / annotation>< / semantics>< / com:Math> cycloalkyl ring (preferably a <com:Math><semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics>< / com:Math> cycloalkyl ring, more preferably a C<com:Sub>3-8< / com:Sub> cycloalkyl ring, further preferably a C<com:Sub>3-6< / com:Sub> cycloalkyl ring) or a 3- to 15-membered heterocycloalkyl ring (preferably a 3- to 10-membered heterocycloalkyl ring, more preferably a 3- to 8- membered heterocycloalkyl ring, further preferably a 3- to 6-membered heterocycloalkyl ring); the C<com:Sub>1-8< / com:Sub> alkyl, C<com:Sub>1-8< / com:Sub> haloalkyl, C<com:Sub>1-8< / com:Sub> alkoxy, C<com:Sub>1-8< / com:Sub> haloalkoxy, -COC<com:Sub>1-8< / com:Sub> alkyl, -COOC<com:Sub>1-8< / com:Sub> alkyl, -OCOC<com:Sub>1-8< / com:Sub> alkyl, - <com:Math><semantics>CONH2<annotation encoding="application / x-tex">CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHC1−8<annotation encoding="application / x-tex">-CONHC_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CON(C1−8<annotation encoding="application / x-tex">-CON(C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−SOC1−8<annotation encoding="application / x-tex">-SOC_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2C1−8<annotation encoding="application / x-tex">-SO_2C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−8<annotation encoding="application / x-tex">-OSO_2C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-8< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-8< / com:Sub> cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10- membered heteroaryl, C<com:Sub>6-14< / com:Sub> aryl, C<com:Sub>3-15< / com:Sub> cycloalkyl ring and 3- to 15-membered heterocycloalkyl ring are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkoxy, -COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> 6 alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 12-membered heterocycloalkyl (preferably 4- to 8- membered heterocycloalkyl, more preferably 4- to 6-membered heterocycloalkyl) and 5- to 10- membered heteroaryl (preferably 5- to 6-membered heteroaryl); <com:Math><semantics>(R2)n2<annotation encoding="application / x-tex">(R_2)_{n2}< / annotation>< / semantics>< / com:Math> represents substitution of hydrogen on ring A1 by n2 R<com:Sub>2< / com:Sub>, n2 is 0, 1 or 2, each R<com:Sub>2< / com:Sub> is identical or different, and each <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, C<com:Sub>1-8< / com:Sub> alkyl (preferably C<com:Sub>1-6< / com:Sub> alkyl, more preferably C<com:Sub>1-3< / com:Sub> alkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy, more preferably C<com:Sub>1-3< / com:Sub> haloalkoxy), -NHC<com:Sub>1-8< / com:Sub> alkyl (preferably -NHC<com:Sub>1-6< / com:Sub> alkyl, more preferably -NHC<com:Sub>1-3< / com:Sub> alkyl), -N(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -N(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, more preferably -N(<com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>), -COC<com:Sub>1-8< / com:Sub> alkyl (preferably -COC<com:Sub>1-6< / com:Sub> alkyl, more preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -OCOC<com:Sub>1-8< / com:Sub> alkyl (preferably -OCOC<com:Sub>1-6< / com:Sub> alkyl, more preferably - OCOC<com:Sub>1-3< / com:Sub> alkyl), -COOC<com:Sub>1-8< / com:Sub> alkyl (preferably -COOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -COOC<com:Sub>1-3< / com:Sub> alkyl), - CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-8< / com:Sub> alkyl (preferably -CONHC<com:Sub>1-6< / com:Sub> alkyl, more preferably -CONHC<com:Sub>1-3< / com:Sub> alkyl), -CON(C<com:Sub>1-1< / com:Sub> 8 alkyl)<com:Sub>2< / com:Sub> (preferably -CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, more preferably -CON(<com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>), -PO(<com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub> (preferably -PO(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, more preferably -PO(<com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>), -SOC<com:Sub>1-8< / com:Sub> alkyl (preferably -SOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SOC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, more preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), - OSO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl (preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, more preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), -SC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-8< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, more preferably -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>), C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 12-membered heterocycloalkyl (preferably 4- to 8-membered heterocycloalkyl, more preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6- membered heteroaryl) and <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl (preferably <com:Math><semantics>C6−12<annotation encoding="application / x-tex">C_{6-12}< / annotation>< / semantics>< / com:Math> aryl); the <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkoxy, -NHC<com:Sub>1-8< / com:Sub> alkyl, -N(<com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, -COC<com:Sub>1-8< / com:Sub> alkyl, -OCOC<com:Sub>1-8< / com:Sub> alkyl, -COOC<com:Sub>1-8< / com:Sub> alkyl, - <com:Math><semantics>CONH2<annotation encoding="application / x-tex">CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHC1−8<annotation encoding="application / x-tex">-CONHC_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CON(C1−8<annotation encoding="application / x-tex">-CON(C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−PO(C1−8<annotation encoding="application / x-tex">-PO(C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−SOC1−8<annotation encoding="application / x-tex">-SOC_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2C1−8<annotation encoding="application / x-tex">-SO_2C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−8<annotation encoding="application / x-tex">-OSO_2C_{1-8}< / annotation>< / semantics>< / com:Math> 8 alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-8< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-8< / com:Sub> cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10-membered heteroaryl, <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkoxy, NHC<com:Sub>1-6< / com:Sub> alkyl, -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -COC<com:Sub>1-6< / com:Sub> alkyl, <com:Math><semantics>−OCOC1−6<annotation encoding="application / x-tex">-OCOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−COOC1−6<annotation encoding="application / x-tex">-COOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CONH2<annotation encoding="application / x-tex">-CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHC1−6<annotation encoding="application / x-tex">-CONHC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CON(C1−6<annotation encoding="application / x-tex">-CON(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−PO(C1−6<annotation encoding="application / x-tex">-PO(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 12-membered heterocycloalkyl (preferably 4- to 8- membered heterocycloalkyl, more preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6-membered heteroaryl) and <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl (preferably <com:Math><semantics>C6−12<annotation encoding="application / x-tex">C_{6-12}< / annotation>< / semantics>< / com:Math> aryl); or R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub> and carbon atom linked to R<com:Sub>1< / com:Sub> and R<com:Sub>2< / com:Sub> together form a 6- to 15-membered heterocycloalkyl ring; the 6- to 15-membered heterocycloalkyl ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkoxy, -NHC<com:Sub>1-6< / com:Sub> alkyl, -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -PO(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 12-membered heterocycloalkyl (preferably 4- to 8- membered heterocycloalkyl, more preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6-membered heteroaryl) and <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl (preferably <com:Math><semantics>C6−12<annotation encoding="application / x-tex">C_{6-12}< / annotation>< / semantics>< / com:Math> aryl); <com:Math><semantics>(R3)n3<annotation encoding="application / x-tex">(R_3)_{n3}< / annotation>< / semantics>< / com:Math> represents substitution of hydrogen on ring A2 by n3 R<com:Sub>3< / com:Sub>, n3 is 0, 1, 2 or 3, each R<com:Sub>3< / com:Sub> is identical or different, and each <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, cyano, carboxyl, nitro, formyl, sulfo, halogen, oxo, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl (preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, further preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, further preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl), <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkoxy (preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, further preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy), <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkoxy, more preferably C<com:Sub>1-6< / com:Sub> haloalkoxy, further preferably C<com:Sub>1-3< / com:Sub> haloalkoxy), -COC<com:Sub>1-10< / com:Sub> alkyl (preferably -COC<com:Sub>1-8< / com:Sub> alkyl, more preferably -COC<com:Sub>1-6< / com:Sub> alkyl, further preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -OCOC<com:Sub>1-10< / com:Sub> alkyl (preferably -OCOC<com:Sub>1-8< / com:Sub> alkyl, more preferably -OCOC<com:Sub>1-6< / com:Sub> alkyl, further preferably -OCOC<com:Sub>1-3< / com:Sub> alkyl), -COOC<com:Sub>1-10< / com:Sub> alkyl (preferably -COOC<com:Sub>1-8< / com:Sub> alkyl, more preferably -COOC<com:Sub>1-6< / com:Sub> alkyl, further preferably -COOC<com:Sub>1-3< / com:Sub> alkyl), -CONH<com:Sub>2< / com:Sub>, - CONHC<com:Sub>1-10< / com:Sub> alkyl (preferably -CONHC<com:Sub>1-8< / com:Sub> alkyl, more preferably -CONHC<com:Sub>1-6< / com:Sub> alkyl, further preferably - CONHC<com:Sub>1-3< / com:Sub> alkyl), -CON(C<com:Sub>1-10< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -CON(C<com:Sub>1-8< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, more preferably -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, further preferably -CON(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>), -SOC<com:Sub>1-10< / com:Sub> alkyl (preferably -SOC<com:Sub>1-8< / com:Sub> alkyl, more preferably -SOC<com:Sub>1< / com:Sub> 6 alkyl, further preferably -SOC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>C<com:Sub>1-10< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl, more preferably - SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, further preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-10< / com:Sub> alkyl (preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl, more preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, further preferably -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-10< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-8< / com:Sub> alkyl, more preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, further preferably -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-3< / com:Sub> alkyl), <com:Math><semantics>−SO2N(C1−10 alkyl)2<annotation encoding="application / x-tex">-SO_2N(C_{1-10} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math> (preferably <com:Math><semantics>−SO2N(C1−8 alkyl)2<annotation encoding="application / x-tex">-SO_2N(C_{1-8} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, more preferably <com:Math><semantics>−SO2N(C1−6 alkyl)2<annotation encoding="application / x-tex">-SO_2N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, further preferably -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>), C<com:Sub>3-8< / com:Sub> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl), 3- to 15-membered heterocycloalkyl (preferably 4- to 12-membered heterocycloalkyl, more preferably 4- to 8-membered heterocycloalkyl, further preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6-membered heteroaryl) and <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl; the <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> 10 haloalkoxy, -COC<com:Sub>1-10< / com:Sub> alkyl, -OCOC<com:Sub>1-10< / com:Sub> alkyl, -COOC<com:Sub>1-10< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-10< / com:Sub> alkyl, - <com:Math><semantics>CON(C1−10 alkyl)2<annotation encoding="application / x-tex">CON(C_{1-10} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOC1−10 alkyl<annotation encoding="application / x-tex">-SOC_{1-10} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2C1−10 alkyl<annotation encoding="application / x-tex">-SO_2C_{1-10} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2C1−10 alkyl<annotation encoding="application / x-tex">-OSO_2C_{1-10} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHC1−10 alkyl<annotation encoding="application / x-tex">-SO_2NHC_{1-10} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$-SO_$ <com:Math><semantics>SO2N(C1−10 alkyl)2<annotation encoding="application / x-tex">SO_2N(C_{1-10} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics>< / com:Math> cycloalkyl, 3- to 15-membered heterocycloalkyl, 5- to 10-membered heteroaryl, <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkoxy, -COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-6< / com:Sub> cycloalkyl, 3- to 15-membered heterocycloalkyl (preferably 4- to 12-membered heterocycloalkyl, more preferably 4- to 8-membered heterocycloalkyl, further preferably 4- to 6-membered heterocycloalkyl), 5- to 10-membered heteroaryl (preferably 5- to 6-membered heteroaryl), phenyl and naphthyl; <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> in <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is a point of attachment of POI to L or ULM, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, ring A1 is an 8- to 10-membered heteroaryl ring. In some embodiments, ring A1 is a 9-membered heteroaryl ring or a 10-membered heteroaryl ring. In some embodiments, ring A1 is a 9-membered nitrogen-containing heteroaryl ring or a 10- membered nitrogen-containing heteroaryl ring. In some embodiments, ring A1 is selected from the group consisting of an indolizine ring, a pyrazolopyridine ring, an imidazopyridine ring, a triazolopyridine ring, a tetrazolopyridine ring, a pyrrolopyridazine ring, a pyrazolopyridazine ring, an imidazopyridazine ring, a triazolopyridazine ring, a tetrazolopyridazine ring, a pyrrolopyrimidine ring, a pyrazolopyrimidine ring, an imidazopyrimidine ring, a triazolopyrimidine ring, a tetrazolopyrimidine ring, a pyrrolopyrazine ring, a pyrazolopyrazine ring, an imidazopyrazine ring, a triazolopyrazine ring, a pyridopyridine ring, a pyridopyrazine ring, a pyridopyridazine ring, a pyridotriazine ring, a pyridopyrimidine ring and a tetrazolopyrazine ring. In some embodiments, ring A1 is selected from the group consisting of [1,2,4]triazolo[4,3- c]pyrimidine, imidazo[1,5-c]pyrimidine, imidazo[1,2-c]pyrimidine, [1,2,4]triazolo[4,3-a]pyridine and pyrido[3,4-d]pyridazine. In some embodiments, ring A1 is a 5- to 6-membered heterocycloalkyl ring. In some embodiments, ring A1 is selected from the group consisting of pyrimidin-4(3H)-one, 1,6- dihydropyrimidine, pyridin-2(1H)-one, 1,2-dihydropyridine and 3,8-diazabicyclo[3.2.1]octane. In some embodiments, ring A1 is an 18-membered heterocycloalkyl ring. In some embodiments, ring A1 is a partially unsaturated 18-membered heterocycloalkyl ring. In some embodiments, ring A1 is selected from the group consisting of 2,3-dihydro-7'H- spiro[indene-1,8'-pyrido[3,4-d]pyridazin]-7'-one and 2,3-dihydro-7'H-spiro[indene-1,8'-pyrido[4,3- c]pyridazin]-7'-one. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: and [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: and [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: and . In some embodiments, POI is a structure of formula (A-2-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(A−2−1)<annotation encoding="application / x-tex">(A-2-1)< / annotation>< / semantics>< / com:Math> , wherein, W<com:Sub>1< / com:Sub>, W<com:Sub>2< / com:Sub>, W<com:Sub>3< / com:Sub>, W<com:Sub>4< / com:Sub>, W<com:Sub>5< / com:Sub> and W<com:Sub>6< / com:Sub> are each independently CH or N; ring A2, R<com:Sub>1< / com:Sub>, n1, R<com:Sub>2< / com:Sub>, n2, R<com:Sub>3< / com:Sub> and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-2-2) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(A−2−2)<annotation encoding="application / x-tex">(A-2-2)< / annotation>< / semantics>< / com:Math> wherein, W1, W2, W3, W4 and W5 are each independently CH or N; ring A2, R1, n1, R2, n2, R3 and , n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-3) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] 2 wherein, ring A2, R1, n1, R2, n2, R3 and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-4) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(A−4)<annotation encoding="application / x-tex">(A-4)< / annotation>< / semantics>< / com:Math> 9 wherein, ring A2, R<com:Sub>1< / com:Sub>, n1, R<com:Sub>2< / com:Sub>, n2, R<com:Sub>3< / com:Sub> and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-5) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] 9 wherein, ring A2, R<com:Sub>1< / com:Sub>, n1, R<com:Sub>2< / com:Sub>, n2, R<com:Sub>3< / com:Sub> and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-6) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] ) wherein, ring A2, R1, n1, R2, n2, R3 and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-7) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] , wherein, ring A2, R<com:Sub>1< / com:Sub>, n1, R<com:Sub>2< / com:Sub>, n2, R<com:Sub>3< / com:Sub> and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, POI is a structure of formula (A-8) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] , wherein, ring A2, R<com:Sub>1< / com:Sub>, n1, R<com:Sub>2< / com:Sub>, n2, R<com:Sub>3< / com:Sub> and n3 are as defined in the specification, and at least one of <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, ring A2 is absent or is selected from the group consisting of a 4- to 8- membered heterocycloalkyl ring, a C<com:Sub>4-8< / com:Sub> cycloalkyl ring, a 5- to 10-membered heteroaryl ring, a 10- to 15-membered heterocycloalkyl ring and a benzene ring. In some embodiments, ring A2 is absent or is selected from the group consisting of a 4- to 8- membered heterocycloalkyl ring, a saturated C<com:Sub>4-8< / com:Sub> cycloalkyl ring, a 5- to 10-membered heteroaryl ring, a partially unsaturated 10- to 15-membered heterocycloalkyl ring and a benzene ring. In some embodiments, ring A2 is absent or is selected from the group consisting of a cyclobutane ring, a cyclopentane ring, a cyclohexane ring, an azetidine ring, a tetrahydropyrrole ring, a pyrazolidine ring, an imidazolidine ring, a piperidine ring, a hexahydropyridazine ring, a hexahydropyrimidine ring, a piperazine ring, a benzene ring, a pyrazole ring, an oxazole ring, an imidazole ring, a triazole ring, a tetrazole ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, an indolizine ring, pyrazolopyridine, imidazopyridine, triazolopyridine, tetrazolopyridine, pyrrolopyridazine, pyrazolopyridazine, imidazopyridazine, triazolopyridazine, tetrazolopyridazine, pyrrolopyrimidine, pyrazolopyrimidine, imidazopyrimidine, triazolopyrimidine, tetrazolopyrimidine, pyrrolopyrazine, pyrazolopyrazine, imidazopyrazine, triazolopyrazine, tetrazolopyrazine, pyridopyridine, pyridopyrazine, pyridopyridazine, pyridotriazine, pyridopyrimidine, 3,8-diazabicyclo[3.2.1]octane and 2,3-dihydrospiro[indene-1,4'-piperidine]. In some embodiments, ring A2 is absent or is selected from the group consisting of a saturated 6- membered heterocycloalkyl ring, a partially unsaturated 12-membered heterocycloalkyl ring, a cyclohexane ring, a 5- to 6-membered heteroaryl ring, a 9-membered heteroaryl ring and a benzene ring. In some embodiments, ring A2 is absent or is selected from the group consisting of a cyclohexane ring, a piperidine ring, a piperazine ring, a benzene ring, a pyridine ring, a pyrazole ring, a triazolopyridine ring and 2,3-dihydrospiro[indene-1,4'-piperidine]. In some embodiments, ring A2 is selected from the group consisting of a benzene ring, a pyridine ring and a pyrazole ring. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following structures or isomers thereof: `NH NHN-W NH-N N= N.NH N.NH N.NH N.NH N.NH N.NH N.NH N.NH In some embodiments, is selected from the group consisting of the following structures: NH-N N-N N-N N-N N-N N-N N-N N-N N-N N-N N and W O-N [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following structures [Image disponible dans le document PDF, Image available in the PDF document] or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following structures [Image disponible dans le document PDF, Image available in the PDF document] or isomers thereof: In some embodiments, n1 is 0. In some embodiments, n1 is 1 or 2. In some embodiments, n1 is 1. In some embodiments, R<com:Sub>1< / com:Sub> is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, isopropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, methoxy, ethoxy, propoxy, isopropoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolyl, pyrazolyl, pyridinyl, phenyl, pyrimidinyl, -CH<com:Sub>2< / com:Sub>-cyclopropyl, -CH<com:Sub>2< / com:Sub>-tetrahydropyrrolyl, -CH<com:Sub>2< / com:Sub>-pyrrolyl, -CH<com:Sub>2< / com:Sub>- phenyl, -CH<com:Sub>2< / com:Sub>-pyridinyl, -CH<com:Sub>2< / com:Sub>-cyclohexenyl, -CH<com:Sub>2< / com:Sub>-azetidine, -CH<com:Sub>2< / com:Sub>-piperidine, -CH<com:Sub>2< / com:Sub>-piperazine, tetrahydro-2H-pyran and -CH<com:Sub>2< / com:Sub>-(tetrahydro-2H-pyran). In some embodiments, R<com:Sub>1< / com:Sub> is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, iodine, -CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -CHF<com:Sub>2< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -OCH<com:Sub>3< / com:Sub>, - OCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -OCH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>5< / com:Sub>, -OCF<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, -CH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub> and -OCH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>. In some embodiments, <com:Math><semantics>n1<annotation encoding="application / x-tex">n1< / annotation>< / semantics>< / com:Math> is 1, and <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> is fluorine. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, In some embodiments, two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and carbon atom linked to the two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> together form a cyclopropyl ring, a cyclobutyl ring, a cyclopentyl ring, a cyclohexyl ring, a cyclobutene ring, a cyclopentene ring, a cyclohexene ring, an azetidine ring, a tetrahydropyrrole ring, a piperidine ring or a piperazine ring. In some embodiments, two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> and carbon atom linked to the two <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math> together form a cyclopropyl ring. In some embodiments, n3 is 3, one R<com:Sub>3< / com:Sub> is fluorine, and the other two R<com:Sub>3< / com:Sub> and carbon atom linked to the other two R<com:Sub>3< / com:Sub> together form a cyclopropane ring. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is In some embodiments, R<com:Sub>2< / com:Sub> is selected from the group consisting of X<com:Sub>1< / com:Sub>, hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHC<com:Sub>1-6< / com:Sub> alkyl, -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -PO(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SC<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl and C<com:Sub>1-6< / com:Sub> haloalkoxy. In some embodiments, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHC<com:Sub>1-6< / com:Sub> alkyl, -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -COC<com:Sub>1-3< / com:Sub> alkyl, -COOC<com:Sub>1-3< / com:Sub> alkyl, -OCOC<com:Sub>1-3< / com:Sub> alkyl, -PO(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-3< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl, -SC<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkyl and C<com:Sub>1-3< / com:Sub> haloalkoxy. In some embodiments, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHCH<com:Sub>3< / com:Sub>, -N(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -CONH<com:Sub>2< / com:Sub>, -CONHCH<com:Sub>3< / com:Sub>, - CON(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -COCH<com:Sub>3< / com:Sub>, -COC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -COOCH<com:Sub>3< / com:Sub>, -COOCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -COOC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>3< / com:Sub>, - <com:Math><semantics>OCOCH2CH3<annotation encoding="application / x-tex">OCOCH_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OCOC(CH3)3<annotation encoding="application / x-tex">-OCOC(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−PO(CH3)2<annotation encoding="application / x-tex">-PO(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−PO(CH2CH3)2<annotation encoding="application / x-tex">-PO(CH_2CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOCH3<annotation encoding="application / x-tex">-SOCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOCH2CH3<annotation encoding="application / x-tex">-SOCH_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOC(CH3)3<annotation encoding="application / x-tex">-SOC(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOC(CH3)3<annotation encoding="application / x-tex">-SOC(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOCH3<annotation encoding="application / x-tex">-SOCH_3< / annotation>< / semantics>< / com:Math> SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>C(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>C(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -SCH<com:Sub>3< / com:Sub>, -SCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, methyl, ethyl, propyl, isopropyl, tert-butyl, methoxy, ethoxy, propoxy, isopropoxy, tert-butoxy, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, monofluoropropyl, difluoropropyl, trifluoropropyl, monofluoroisopropyl, difluoroisopropyl, trifluoroisopropyl, monofluoro-tert-butyl, difluoro-tert-butyl, trifluoro-tert-butyl, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, monofluoropropoxy, difluoropropoxy, trifluoropropoxy, monofluoroisopropoxy, difluoroisopropoxy, trifluoroisopropoxy, monofluoro-tert-butoxy, difluoro-tert-butoxy and trifluoro-tert-butoxy. In some embodiments, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, halogen, cyano, - <com:Math><semantics>SO2C1−6<annotation encoding="application / x-tex">SO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl and <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl. In some embodiments, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, halogen, cyano, - <com:Math><semantics>SO2C1−3<annotation encoding="application / x-tex">SO_2C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, and <com:Math><semantics>−OSO2C1−3<annotation encoding="application / x-tex">-OSO_2C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl. In some embodiments, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, hydrogen, fluorine, chlorine, bromine, iodine, cyano, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> and -OSO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>. In some embodiments, R<com:Sub>2< / com:Sub> is selected from the group consisting of cyano, fluorine, chlorine, bromine, iodine, -CH<com:Sub>3< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, hydrogen and -PO(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>. In some embodiments, R<com:Sub>2< / com:Sub> is selected from the group consisting of cyano, chlorine, bromine, - SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> and hydrogen. In some embodiments, n2 is 1, and R2 is selected from the group consisting of X1, hydrogen, fluorine, chlorine, bromine, iodine, -CH<com:Sub>3< / com:Sub>, cyano, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> and -PO(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>. In some embodiments, n2 is 1, and R2 is selected from the group consisting of cyano, fluorine, chlorine, bromine, iodine, -CH<com:Sub>3< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, hydrogen and -PO(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>. In some embodiments, n2 is 1, and R2 is selected from the group consisting of cyano, chlorine, bromine, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> and hydrogen. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] , [Image disponible dans le document PDF, Image available in the PDF document] wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: In some embodiments, R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub> and carbon atom linked to R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub> together form a 6- to 15-membered heterocycloalkyl ring, the 6- to 15-membered heterocycloalkyl ring is selected from the group consisting of 5,8-dihydro-4H-1,4-oxazocine, 4,5,8,9-tetrahydro-1,4-oxazepine, 5,8,9,10-tetrahydro-4H-1,4- oxazonine, and 1-oxa-4-azacycloundeca-2,6-diene; the 6- to 15-membered heterocycloalkyl ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: fluorine, chlorine, bromine, iodine, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, methyl, ethyl, isopropyl, tert- butyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, methoxy, ethoxy, isopropoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, -COCH<com:Sub>3< / com:Sub>, -COCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, - COCH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -COC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCOCH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -OCOC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -CONH<com:Sub>2< / com:Sub>, - CONHCH<com:Sub>3< / com:Sub>, -CONHCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CONHCH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -CONHC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -CON(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -CON(CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, - SOCH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>C(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OSO<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, - <com:Math><semantics>OSO2CH(CH3)2<annotation encoding="application / x-tex">OSO_2CH(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2C(CH3)3<annotation encoding="application / x-tex">-OSO_2C(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH2CH3<annotation encoding="application / x-tex">-SO_2NHCH_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH(CH3)2<annotation encoding="application / x-tex">-SO_2NHCH(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH<annotation encoding="application / x-tex">-SO_2NHCH< / annotation>< / semantics>< / com:Math> SO<com:Sub>2< / com:Sub>NHC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>N(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>N(CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, azetidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, pyridinyl, phenyl and pyrimidinyl. In some embodiments, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and carbon atom linked to <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> together form 4,5,8,9-tetrahydro- 1,4-oxazepine, 5,8-dihydro-4H-1,4-oxazocine, 5,8,9,10-tetrahydro-4H-1,4-oxazonine, or 1-oxa-4- azacycloundeca-2,6-diene. In some embodiments, <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and carbon atom linked to <com:Math><semantics>R1<annotation encoding="application / x-tex">R_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> together form <com:Math><semantics>(2Z,6Z)−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8,9−4,5,8<annotation encoding="application / x-tex">(2Z,6Z)-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8,9-4,5,8< / annotation>< / semantics>< / com:Math> tetrahydro-1,4-oxazepine, (2E,6Z)-4,5,8,9-tetrahydro-1,4-oxazepine, (2E,6E)-4,5,8,9-tetrahydro-1,4- oxazepine, (2Z,6E)-4,5,8,9-tetrahydro-1,4-oxazepine, (2Z,6Z)-5,8-dihydro-4H-1,4-oxazocine, (2E,6Z)- 5,8-dihydro-4H-1,4-oxazocine, (2Z,6E)-5,8-dihydro-4H-1,4-oxazocine, (2E,6E)-5,8-dihydro-4H-1,4- oxazocine, (2Z,6Z)-5,8,9,10-tetrahydro-4H-1,4-oxazonine, (2E,6Z)-5,8,9,10-tetrahydro-4H-1,4- oxazonine, (2Z,6E)-5,8,9,10-tetrahydro-4H-1,4-oxazonine, (2E,6E)-5,8,9,10-tetrahydro-4H-1,4- oxazonine, (2Z,6Z)-1-oxa-4-azacycloundeca-2,6-diene, (2E,6Z)-1-oxa-4-azacycloundeca-2,6-diene, (2Z,6E)-1-oxa-4-azacycloundeca-2,6-diene or (2E,6E)-1-oxa-4-azacycloundeca-2,6-diene. In some embodiments, R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub> and carbon atom linked to R<com:Sub>1< / com:Sub>, R<com:Sub>2< / com:Sub> together form (2Z,6Z)-4,5,8,9- tetrahydro-1,4-oxazepine, (2Z,6Z)-5,8-dihydro-4H-1,4-oxazocine, (2Z,6Z)-5,8,9,10-tetrahydro-4H-1,4- oxazonine or (2Z,6Z)-1-oxa-4-azacycloundeca-2,6-diene. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 9 , and [Image disponible dans le document PDF, Image available in the PDF document] , wherein ---- represents — (single bond) or === (double bond); n1 is 0 or 1, and n2 is 0 or 1. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(R2)n2<annotation encoding="application / x-tex">(R_2)_{n2}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>(R1)n1<annotation encoding="application / x-tex">(R_1)_{n1}< / annotation>< / semantics>< / com:Math> , 9 and <com:Math><semantics>(R2)n2<annotation encoding="application / x-tex">(R_2)_{n2}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>(R1)n1<annotation encoding="application / x-tex">(R_1)_{n1}< / annotation>< / semantics>< / com:Math> ; wherein n1 is 0 or 1, and n2 is 0 or 1. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] از and [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] E and [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, • In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, halogen, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, C<com:Sub>3-8< / com:Sub> cycloalkyl, -COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, - SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl; the C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, C<com:Sub>3-8< / com:Sub> cycloalkyl, - COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> 6 alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, 4- to 8- membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> haloalkyl, C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkoxy, -COC<com:Sub>1-3< / com:Sub> alkyl, -COOC<com:Sub>1-3< / com:Sub> alkyl, - <com:Math><semantics>CONH2<annotation encoding="application / x-tex">CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHC1−3<annotation encoding="application / x-tex">-CONHC_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CON(C1−3<annotation encoding="application / x-tex">-CON(C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−SOC1−3<annotation encoding="application / x-tex">-SOC_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2C1−3<annotation encoding="application / x-tex">-SO_2C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−3<annotation encoding="application / x-tex">-OSO_2C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-3< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>3-6< / com:Sub> cycloalkyl, 4- to 6-membered heterocycloalkyl, 5- to 6- membered heteroaryl and phenyl. In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, halogen, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, C<com:Sub>3-8< / com:Sub> cycloalkyl, -COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, - SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl; the <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy, <com:Math><semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics>< / com:Math> cycloalkyl, - COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> 6 alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -OSO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, 4- to 8- membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, methyl, trifluoromethyl, methoxy, trifluoromethoxy, -COCH<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>3< / com:Sub>, -COOCH<com:Sub>3< / com:Sub>, - <com:Math><semantics>CONH2<annotation encoding="application / x-tex">CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHCH3<annotation encoding="application / x-tex">-CONHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CON(CH3)2<annotation encoding="application / x-tex">-CON(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOCH3<annotation encoding="application / x-tex">-SOCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2CH3<annotation encoding="application / x-tex">-SO_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(CH3)2<annotation encoding="application / x-tex">-SO_2N(CH_3)_2< / annotation>< / semantics>< / com:Math>, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, azetidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl and phenyl. 5 In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, halogen, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, C<com:Sub>3-8< / com:Sub> cycloalkyl, -COC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, <com:Math><semantics>−CO2NH2<annotation encoding="application / x-tex">-CO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONHC1−6<annotation encoding="application / x-tex">-CONHC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CON(C1−6<annotation encoding="application / x-tex">-CON(C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>−SOC1−6<annotation encoding="application / x-tex">-SOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−SO2C1−6<annotation encoding="application / x-tex">-SO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−OSO2C1−6<annotation encoding="application / x-tex">-OSO_2C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−O<annotation encoding="application / x-tex">-O< / annotation>< / semantics>< / com:Math> SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NHC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl. In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, tert-butyl, methoxy, ethoxy, isopropoxy, tert-butoxy, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, -COCH<com:Sub>3< / com:Sub>, -COCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -COC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCOC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, - COOCH<com:Sub>3< / com:Sub>, -COOCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -COOC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -CONH<com:Sub>2< / com:Sub>, -CONHCH<com:Sub>3< / com:Sub>, -CON(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -SOCH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, - <com:Math><semantics>SO2C(CH3)3<annotation encoding="application / x-tex">SO_2C(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2CH3<annotation encoding="application / x-tex">-OSO_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OSO2C(CH3)3<annotation encoding="application / x-tex">-OSO_2C(CH_3)_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2N(CH3)2<annotation encoding="application / x-tex">-SO_2N(CH_3)_2< / annotation>< / semantics>< / com:Math>, cyclopropyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, azetidinyl, piperazinyl, piperidinyl, 1,2,3,6-tetrahydropyridinyl, pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrimidinyl and phenyl. In some embodiments, R<com:Sub>3< / com:Sub> is selected from the group consisting of X<com:Sub>1< / com:Sub>, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>3-8< / com:Sub> cycloalkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl and <com:Math><semantics>−COC1−6<annotation encoding="application / x-tex">-COC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl. In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>< / com:Math> cycloalkyl, <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl and <com:Math><semantics>−COC1−3<annotation encoding="application / x-tex">-COC_{1-3}< / annotation>< / semantics>< / com:Math> alkyl. In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, methyl, cyclopropyl, 25 trifluoromethyl and -COCH<com:Sub>3< / com:Sub>. In some embodiments, <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, fluorine and methyl. In some embodiments, n3 is 0. In some embodiments, n3 is 1, and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, methyl, cyclopropyl, trifluoromethyl and -COCH<com:Sub>3< / com:Sub>. In some embodiments, <com:Math><semantics>n3<annotation encoding="application / x-tex">n3< / annotation>< / semantics>< / com:Math> is 1, and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> is methyl. In some embodiments, n3 is 2, and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> are <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> and methyl, respectively. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] , [Image disponible dans le document PDF, Image available in the PDF document] 5 point of attachment to L or ULM. <com:Math><semantics>(R3)n3<annotation encoding="application / x-tex">(R_3)_{n3}< / annotation>< / semantics>< / com:Math> In some embodiments, (AZ) is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X3<annotation encoding="application / x-tex">X_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X4<annotation encoding="application / x-tex">X_4< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X4<annotation encoding="application / x-tex">X_4< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X5<annotation encoding="application / x-tex">X_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X4<annotation encoding="application / x-tex">X_4< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X5<annotation encoding="application / x-tex">X_5< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X7<annotation encoding="application / x-tex">X_7< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{c|ccccccccccccccccccccccccccccccccccc of attachment to L or ULM. <com:Math><semantics>(R3)n3<annotation encoding="application / x-tex">(R_3)_{n3}< / annotation>< / semantics>< / com:Math> In some embodiments, is selected from the group consisting of the following structures f: <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X3<annotation encoding="application / x-tex">X_3< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X4<annotation encoding="application / x-tex">X_4< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X5<annotation encoding="application / x-tex">X_5< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X4<annotation encoding="application / x-tex">X_4< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X5<annotation encoding="application / x-tex">X_5< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X5<annotation encoding="application / x-tex">X_5< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X6<annotation encoding="application / x-tex">X_6< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X7<annotation encoding="application / x-tex">X_7< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X8<annotation encoding="application / x-tex">X_8< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X9<annotation encoding="application / x-tex">X_9< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X<annotation encoding="application / x-tex">X< / annotation>< / semantics>< / com:Math> or isomers thereof: attachment to L or ULM. <com:Math><semantics>(R3)n3<annotation encoding="application / x-tex">(R_3)_{n3}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>−(A2)<annotation encoding="application / x-tex">-(A2)< / annotation>< / semantics>< / com:Math> In some embodiments, is selected from the group consisting of the following structures or isomers thereof: ; <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. <com:Math><semantics>(R3)n3<annotation encoding="application / x-tex">(R_3)_{n3}< / annotation>< / semantics>< / com:Math> In some embodiments is selected from the group consisting of the following structures or isomers thereof and ; <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. In some embodiments, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−19−<annotation encoding="application / x-tex">-19-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. In some embodiments, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. In some embodiments, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. 5 In some embodiments, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−21−<annotation encoding="application / x-tex">-21-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] IN wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. In some embodiments, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> . . wherein <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math> is the point of attachment to L or ULM. 5 In some embodiments, L is a structure of formula (L-1) or an isomer thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein m1 is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; each L<com:Sub>a< / com:Sub> at each occurrence is independently selected from the group consisting of a chemical bond, -C(O)-, -C(O)NR<com:Sub>L1< / com:Sub>-, -NR<com:Sub>L1< / com:Sub>-, -O-, -S-, C<com:Sub>1-10< / com:Sub> alkylene (preferably C<com:Sub>1-8< / com:Sub> alkylene, more preferably C<com:Sub>1-6< / com:Sub> alkylene, further preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene), <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyleneoxy (preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyleneoxy, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyleneoxy, further preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyleneoxy), <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenylene (preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenylene, more preferably <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkenylene, further preferably <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkenylene), <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynylene (preferably C<com:Sub>2-8< / com:Sub> alkynylene, more preferably C<com:Sub>2-6< / com:Sub> alkynylene, further preferably C<com:Sub>2-4< / com:Sub> alkynylene), a C<com:Sub>3-< / com:Sub> 15 cycloalkylene ring (preferably a C<com:Sub>3-10< / com:Sub> cycloalkylene ring, more preferably a C<com:Sub>3-8< / com:Sub> cycloalkylene ring, further preferably a C<com:Sub>3-6< / com:Sub> cycloalkylene ring), a 3- to 15-membered heterocycloalkylene ring (preferably a 4- to 12-membered heterocycloalkylene ring, more preferably a 4- to 10-membered heterocycloalkylene ring, further preferably a 4- to 8-membered heterocycloalkylene ring, further preferably a 4- to 6-membered heterocycloalkylene ring), a 5- to 15-membered heteroarylene ring (preferably a 5- to 14-membered heteroarylene ring, more preferably a 5- to 12-membered heteroarylene ring, further preferably a 5- to 10-membered heteroarylene ring, further preferably a 5- to 6-membered heteroarylene ring) and a <com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> arylene ring (preferably a phenylene ring or a naphthylene ring); the <com:Math><semantics>C1−1<annotation encoding="application / x-tex">C_{1-1}< / annotation>< / semantics>< / com:Math> <com:Sub>10< / com:Sub> alkylene, C<com:Sub>1-10< / com:Sub> alkyleneoxy, C<com:Sub>2-10< / com:Sub> alkenylene, C<com:Sub>2-10< / com:Sub> alkynylene, C<com:Sub>3-15< / com:Sub> cycloalkylene ring, 3- to 15- membered heterocycloalkylene ring, 5- to 15-membered heteroarylene ring and C<com:Sub>6-14< / com:Sub> arylene ring are 25 unsubstituted or substituted with 1, 2, 3 or 4 R<com:Sub>L2< / com:Sub>, the each R<com:Sub>L2< / com:Sub> is independently selected from the group consisting of deuterium, halogen (preferably fluorine, chlorine or bromine), hydroxyl, cyano, amino, carboxyl, formyl, oxo, sulfo, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy, hydroxy-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, cyano-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, amino-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>< / com:Math> cycloalkyl, C<com:Sub>3-6< / com:Sub> cycloalkyl C<com:Sub>1-6< / com:Sub> alkyl, 3- to 6-membered heterocycloalkyl, 3- to 6-membered heterocycloalkyl C<com:Sub>1-6< / com:Sub> alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl C<com:Sub>1-6< / com:Sub> alkyl, phenyl, phenyl C<com:Sub>1-6< / com:Sub> alkyl, -COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, <com:Math><semantics>−CON(C1−6 alkyl)2<annotation encoding="application / x-tex">-CON(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOC1−6 alkyl<annotation encoding="application / x-tex">-SOC_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2C1−6 alkyl<annotation encoding="application / x-tex">-SO_2C_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHC1−6 alkyl<annotation encoding="application / x-tex">-SO_2NHC_{1-6} \text{ alkyl}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−SO2N(C1−6 alkyl)2<annotation encoding="application / x-tex">-SO_2N(C_{1-6} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>; each R<com:Sub>L1< / com:Sub> at each occurrence is independently selected from the group consisting of hydrogen, deuterium, <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkoxy) and <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl). In some embodiments, each R<com:Sub>L1< / com:Sub> at each occurrence is independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tert-butyl, methoxy, ethoxy, isopropoxy, tert-butoxy, trifluoromethyl, difluoromethyl, monofluoromethyl, trifluoroethyl, difluoroethyl, monofluoroethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoroethoxy, difluoroethoxy and monofluoroethoxy. In some embodiments, each R<com:Sub>L1< / com:Sub> at each occurrence is independently selected from the group consisting of hydrogen, methyl, ethyl, difluoromethyl and monofluoromethyl. In some embodiments, R<com:Sub>L1< / com:Sub> is hydrogen. In some embodiments, each R<com:Sub>L2< / com:Sub> is independently selected from the group consisting of deuterium, halogen (preferably fluorine, chlorine or bromine), hydroxyl, cyano, amino, carboxyl, hydroxymethyl, hydroxyethyl, methyl, ethyl, difluoromethyl, monofluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, cyclopentenyl, tetrahydropyrrolyl, tetrahydrofuranyl, phenyl, pyrrolyl, furanyl, thienyl, thiazolyl, oxazolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, -CH<com:Sub>2< / com:Sub>-cyclopropyl, -CH<com:Sub>2< / com:Sub>-cyclobutyl, -CH<com:Sub>2< / com:Sub>-cyclopentyl, -CH<com:Sub>2< / com:Sub>-cyclohexyl, -CH<com:Sub>2< / com:Sub>-cyclohexenyl, -CH<com:Sub>2< / com:Sub>-cyclopentenyl, -CH<com:Sub>2< / com:Sub>-tetrahydropyrrolyl, -CH<com:Sub>2< / com:Sub>-tetrahydrofuranyl, -CH<com:Sub>2< / com:Sub>-phenyl, -CH<com:Sub>2< / com:Sub>-pyrrolyl, - CH<com:Sub>2< / com:Sub>-triazolyl, -CH<com:Sub>2< / com:Sub>-tetrazolyl, -CH<com:Sub>2< / com:Sub>-pyridinyl, -CH<com:Sub>2< / com:Sub>-pyrazinyl, -CH<com:Sub>2< / com:Sub>-triazinyl, methoxy, ethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethoxy, acetyl, acetylamino and sulfonamido. In some embodiments, each <com:Math><semantics>RL2<annotation encoding="application / x-tex">R_{L2}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of deuterium, -F, -Cl, -Br, -OH, -CN, -CHO, -COOH, -NH<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>OH, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OH, -CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -CHF<com:Sub>2< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, -CH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -OCH<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>F, -OCHF<com:Sub>2< / com:Sub>, -OCF<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, - OCH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -COCH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>-cyclopropyl, cyclopropyl, -CONH<com:Sub>2< / com:Sub>, -COOCH<com:Sub>3< / com:Sub>, -OCOCH<com:Sub>3< / com:Sub>, - <com:Math><semantics>CONHCH3<annotation encoding="application / x-tex">CONHCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CON(CH3)2<annotation encoding="application / x-tex">-CON(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SOCH3<annotation encoding="application / x-tex">-SOCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2CH3<annotation encoding="application / x-tex">-SO_2CH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NH2<annotation encoding="application / x-tex">-SO_2NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−SO2NHCH3<annotation encoding="application / x-tex">-SO_2NHCH_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−SO2N(CH3)2<annotation encoding="application / x-tex">-SO_2N(CH_3)_2< / annotation>< / semantics>< / com:Math>. In some embodiments, each <com:Math><semantics>RL2<annotation encoding="application / x-tex">R_{L2}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of deuterium, -F, -Cl, -Br, -OH, -CN, -COOH, -NH<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>OH, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OH, -CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -CHF<com:Sub>2< / com:Sub>, -CF<com:Sub>3< / com:Sub>, - CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, -CH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -OCH<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -OCH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>F, - OCH<com:Sub>2< / com:Sub>CHF<com:Sub>2< / com:Sub>, -OCH<com:Sub>2< / com:Sub>CF<com:Sub>3< / com:Sub>, -COCH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>-cyclopropyl, cyclopropyl and -CONH<com:Sub>2< / com:Sub>. In some embodiments, each R<com:Sub>L2< / com:Sub> is independently selected from the group consisting of fluorine, chlorine, bromine, hydroxy and hydroxymethyl. In some embodiments, each La is independently selected from the group consisting of the following structures or isomers thereof: -C(O)-, -C(O)NH-, -O-, -S-, -NH-, C<com:Sub>1-10< / com:Sub> alkylene, C<com:Sub>1-10< / com:Sub> alkyleneoxy, a C<com:Sub>3-< / com:Sub> <com:Sub>12< / com:Sub> cycloalkylene ring, a 4- to 12-membered heterocycloalkylene ring, a 5- to 6-membered heteroarylene ring and a phenylene ring; the C<com:Sub>3-12< / com:Sub> cycloalkylene ring, 4- to 12-membered heterocycloalkylene ring, 5- to 6-membered heteroarylene ring and phenylene ring are unsubstituted or substituted with 1, 2, 3 or 4 R<com:Sub>L2< / com:Sub>, and R<com:Sub>L2< / com:Sub> is selected from the group consisting of fluorine, hydroxy and hydroxymethyl. In some embodiments, each L<com:Sub>a< / com:Sub> is independently selected from the group consisting of the following structures or isomers thereof: -O-, -S-, -NH-, -C(O)-, -C(O)NH-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>m2< / com:Sub>-, -O(CH<com:Sub>2< / com:Sub>)<com:Sub>m2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>m2< / com:Sub>O-, and a divalent form of a cyclic group selected from the group consisting of: a cyclopropane ring, a cyclobutane ring, a bicyclopentane ring, a cyclopentane ring, a cyclohexane ring, an azetidine ring, a tetrahydropyrrole ring, a piperidine ring, a piperazine ring, a hydroxy-substituted piperidine ring, a hydroxy-substituted piperazine ring, a hydroxymethyl-substituted piperidine ring, a hydroxymethyl- substituted piperazine ring, 3,3,5,5-tetramethylpiperidine, 3,3-difluoropiperidine, a 2- azaspiro[3.3]heptane ring, a 6-azaspiro[3.4]octane ring, a 7-azaspiro[3.5]nonane ring, a 2,6- diazaspiro[3.3]heptane ring, a 2,6-diazaspiro[3.4]octane ring, a 2,7-diazaspiro[3.5]nonane ring, a 2- azaspiro[3.5]nonane ring, a spiro[3.3]heptane ring, spiro[3.4]octane ring, a spiro[3.5]nonane ring, a 3,9- diazaspiro[5.5]undecane, a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a triazine ring, a thiophene ring, a furan ring, a pyrrole ring, a thiazole ring, an oxazole ring, a pyrazole ring, an imidazole ring and a triazole ring; wherein each m2 at each occurrence is independently 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. In some embodiments, each L<com:Sub>a< / com:Sub> is independently selected from the group consisting of the following structures or isomers thereof: -(CH<com:Sub>2< / com:Sub>)-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>5< / com:Sub>-, -C(O)-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-, -C(O)NH-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>8< / com:Sub>-, -O-, - <com:Math><semantics>NH−<annotation encoding="application / x-tex">NH-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, each L<com:Sub>a< / com:Sub> is independently selected from the group consisting of the following structures or isomers thereof: -(CH<com:Sub>2< / com:Sub>)-, <com:Math><semantics>N−N<annotation encoding="application / x-tex">N-N< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>N−N<annotation encoding="application / x-tex">N-N< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>N−N<annotation encoding="application / x-tex">N-N< / annotation>< / semantics>< / com:Math>, and [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, L is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>−(CH2)m3<annotation encoding="application / x-tex">-(CH_2)_{m3}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)−(CH2)m3<annotation encoding="application / x-tex">-C(O)-(CH_2)_{m3}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NH−(CH2)m3<annotation encoding="application / x-tex">-C(O)NH-(CH_2)_{m3}< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)NH−(CH2)m3<annotation encoding="application / x-tex">-C(O)NH-(CH_2)_{m3}< / annotation>< / semantics>< / com:Math>-O-, <com:Math><semantics>−Cy0<annotation encoding="application / x-tex">-Cy_0< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−NH−Cy0<annotation encoding="application / x-tex">-NH-Cy_0< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−Cy0<annotation encoding="application / x-tex">-Cy_0< / annotation>< / semantics>< / com:Math>- <com:Math><semantics>NH−(CH2)m3−<annotation encoding="application / x-tex">NH-(CH_2)_{m3}-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−(CH2)m3−NH−<annotation encoding="application / x-tex">-Cy_0-(CH_2)_{m3}-NH-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−(CH2)m3−O−<annotation encoding="application / x-tex">-Cy_0-(CH_2)_{m3}-O-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−C(O)NH−Cy0−<annotation encoding="application / x-tex">-C(O)NH-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)m3−C(O)NH−(CH2)m3−O−<annotation encoding="application / x-tex">-(CH_2)_{m3}-C(O)NH-(CH_2)_{m3}-O-< / annotation>< / semantics>< / com:Math> <com:Math><semantics>Cy0−O−(CH2)m3−<annotation encoding="application / x-tex">Cy_0-O-(CH_2)_{m3}-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−Cy0−<annotation encoding="application / x-tex">-Cy_0-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)m3−Cy0−O−(CH2)m3−<annotation encoding="application / x-tex">-(CH_2)_{m3}-Cy_0-O-(CH_2)_{m3}-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−C(O)NH−Cy0−<annotation encoding="application / x-tex">-Cy_0-C(O)NH-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−(CH2)m3−Cy0−<annotation encoding="application / x-tex">-Cy_0-(CH_2)_{m3}-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−O−Cy0−<annotation encoding="application / x-tex">-Cy_0-O-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−Cy0−C(O)−Cy0−<annotation encoding="application / x-tex">-Cy_0-C(O)-Cy_0-< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)m3−Cy0−Cy0<annotation encoding="application / x-tex">-(CH_2)_{m3}-Cy_0-Cy_0< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−C(O)NH−(CH2)m3−Cy0−(CH2)m3−Cy0<annotation encoding="application / x-tex">-C(O)NH-(CH_2)_{m3}-Cy_0-(CH_2)_{m3}-Cy_0< / annotation>< / semantics>< / com:Math>; wherein each m3 at each occurrence is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; each Cy<com:Sub>0< / com:Sub> at each occurrence is independently selected from the group consisting of a C<com:Sub>3-12< / com:Sub> cycloalkyl ring (preferably a C<com:Sub>3-10< / com:Sub> 5 cycloalkyl ring, more preferably a C<com:Sub>3-8< / com:Sub> cycloalkyl ring, further preferably a C<com:Sub>3-6< / com:Sub> cycloalkyl ring), a 3- to 12-membered heterocycloalkyl ring (preferably a 3- to 10-membered heterocycloalkyl ring, more preferably a 3- to 8-membered heterocycloalkyl ring, further preferably a 3- to 6-membered heterocycloalkyl ring), a 5- to 6-membered heteroaryl ring and a benzene ring; the C<com:Sub>3-12< / com:Sub> cycloalkyl ring, 3- to 12-membered heterocycloalkyl ring, 5- to 6-membered heteroaryl ring, benzene ring unsubstituted or substituted with 1, 2, 3 or 4 R<com:Sub>L2< / com:Sub>, each R<com:Sub>L2< / com:Sub> at each occurrence is independently selected from the group consisting of deuterium, halogen, hydroxyl, cyano, amino, carboxyl, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkyl, C<com:Sub>1-3< / com:Sub> haloalkoxy, C<com:Sub>1-3< / com:Sub> hydroxy alkyl, cyano-substituted C<com:Sub>1-3< / com:Sub> alkyl, amino-substituted C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkoxy C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>3-6< / com:Sub> cycloalkyl, C<com:Sub>3-6< / com:Sub> cycloalkyl C<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, - <com:Math><semantics>OCOC1−3<annotation encoding="application / x-tex">OCOC_{1-3}< / annotation>< / semantics>< / com:Math> alkyl, <com:Math><semantics>−CONH2<annotation encoding="application / x-tex">-CONH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CONH2−3<annotation encoding="application / x-tex">-CONH_{2-3}< / annotation>< / semantics>< / com:Math> alkyl and <com:Math><semantics>−CON(C1−3<annotation encoding="application / x-tex">-CON(C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>. In some embodiments, each <com:Math><semantics>Cy0<annotation encoding="application / x-tex">Cy_0< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, a bicyclopentane ring, a cyclohexane ring, an azetidine ring, a hydroxy-substituted azetidine ring, a tetrahydropyrrole ring, a piperidine ring, a hydroxy-substituted piperidine ring, a hydroxymethyl-substituted piperidine ring, a 4-fluoropiperidine ring, 3,3-difluoropiperidine, 3,3,5,5-tetramethylpiperidine, a piperazine ring, a 2-azaspiro[3.3]heptane ring, a 6-azaspiro[3.4]octane ring, a 7-azaspiro[3.5]nonane ring, a 2,6-diazaspiro[3.3]heptane ring, a 2,6- diazaspiro[3.4]octane ring, a 2,7-diazaspiro[3.5]nonane ring, a 2-azaspiro[3.5]nonane ring, a spiro[3.3]heptane ring, a spiro[3.4]octane ring, a spiro[3.5]nonane ring, 3,9-diazaspiro[5.5]undecane, a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a triazine ring, a thiophene ring, a furan ring, a pyrrole ring, a thiazole ring, an oxazole ring, a pyrazole ring, an imidazole 25 ring and a triazole ring. In some embodiments, each <com:Math><semantics>Cy0<annotation encoding="application / x-tex">Cy_0< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of a cyclobutane ring, a bicyclopentane ring, a benzene ring, an azetidine ring, a piperidine ring, a piperazine ring, and 3,9-diazaspiro[5.5]undecane. In some embodiments, each <com:Math><semantics>Cy0<annotation encoding="application / x-tex">Cy_0< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of a cyclobutane ring, an azetidine ring, a benzene ring, and a piperidine ring. In some embodiments, each Cy<com:Sub>0< / com:Sub> is independently selected from the group consisting of the [Image disponible dans le document PDF, Image available in the PDF document] following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, each <com:Math><semantics>Cy0<annotation encoding="application / x-tex">Cy_0< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of the following structures or isomers thereof: and ——— In some embodiments, L is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X00∼X00<annotation encoding="application / x-tex">X_{00} \sim X_{00}< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$X_$ <Formule mathématique disponible dans le document PDF, Math available in the PDF document>X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{00} = X_{0 <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00} - N< / annotation>< / semantics>< / com:Math> <Formule mathématique disponible dans le document PDF, Math available in the PDF document>X_{00} \xrightarrow{N} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00 X00 X<com:Sub>00< / com:Sub>\N \_N_X_00 <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">\begin{array}{cccccccccccccccccccccccccccccccccccc <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block"> \begin{array}{cccccccccccccccccccccccccccccccccccc and • wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is a point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers thereof: and ; wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> X<com:Sub>00< / com:Sub> \ <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">X_{00} \bigvee_{O} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{00} X_{0 thereof: <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> N X<com:Sub>00< / com:Sub> wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N−X00<annotation encoding="application / x-tex">N-X_{00}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X00−N<annotation encoding="application / x-tex">X_{00}-N< / annotation>< / semantics>< / com:Math> thereof: , X<com:Sub>00< / com:Sub> \N_ ; wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers X<com:Sub>00< / com:Sub> \ ...X<com:Sub>00< / com:Sub> X<com:Sub>00< / com:Sub>,N `N X<com:Sub>00< / com:Sub> <com:Math><semantics>N−X00<annotation encoding="application / x-tex">N - X_{00}< / annotation>< / semantics>< / com:Math> thereof: and ; wherein <com:Math><semantics>X00<annotation encoding="application / x-tex">X_{00}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM or POI. In some embodiments, L is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> 9 and ; wherein <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> is a point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is a point of attachment of L to ULM. 5 In some embodiments, L is selected from the group consisting of the following structures or isomers <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <Formule mathématique disponible dans le document PDF, Math available in the PDF document>X_{1 thereof: the point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, L is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] thereof: 9 <com:Math><semantics>X10→N(r)→(r)X20<annotation encoding="application / x-tex">X_{10} \xrightarrow{N} (r) \xrightarrow{(r)} X_{20}< / annotation>< / semantics>< / com:Math> <Formule mathématique disponible dans le document PDF, Math available in the PDF document display="block">X_{10} \xrightarrow{N} (r) \xrightarrow{X_{20}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{X_{10}} X_{20} \xrightarrow{ is the point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, L is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>X10→N10X20<annotation encoding="application / x-tex">X_{10} \xrightarrow{N_{10}} X_{20}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X10→N10X20<annotation encoding="application / x-tex">X_{10} \xrightarrow{N_{10}} X_{20}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>X10→N10X20<annotation encoding="application / x-tex">X_{10} \xrightarrow{N_{10}} X_{20}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>X10→N10X20<annotation encoding="application / x-tex">X_{10} \xrightarrow{N_{10}} X_{20}< / annotation>< / semantics>< / com:Math>; wherein <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, L is selected from the group consisting of the following structures or isomers <Formule mathématique disponible dans le document PDF, Math available in the PDF document>X_{10} \rightarrow X_{20} \qquad X_{10} - N \rightarrow X_{20} \qquad X_{10} - N \rightarrow X_{20} \qquad X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10} \rightarrow X_{10 thereof: <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> 9 and X<com:Sub>10< / com:Sub> \ ; wherein <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, L is selected from the group consisting of the following structures or isomers <com:Math><semantics>X10−N<annotation encoding="application / x-tex">X_{10} - N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N−X20<annotation encoding="application / x-tex">N - X_{20}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X10−N<annotation encoding="application / x-tex">X_{10}-N< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> , <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> ; wherein <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> is the point of X<com:Sub>10< / com:Sub> N thereof: X<com:Sub>10< / com:Sub> \ N attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, L is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] thereof: ; wherein <com:Math><semantics>X10<annotation encoding="application / x-tex">X_{10}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to POI, and <com:Math><semantics>X20<annotation encoding="application / x-tex">X_{20}< / annotation>< / semantics>< / com:Math> is the point of attachment of L to ULM. In some embodiments, ULM is a compound of formula (U-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein, ===== represents ==== (double bond) or ——— (single bond); <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math> is a chemical bond, <com:Math><semantics>−N(RU0)<annotation encoding="application / x-tex">-N(R_{U0})< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CON(RU0)<annotation encoding="application / x-tex">-CON(R_{U0})< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>- or <com:Math><semantics>−(CH2)2<annotation encoding="application / x-tex">-(CH_2)_2< / annotation>< / semantics>< / com:Math>-; each R<com:Sub>U0< / com:Sub> at each occurrence is independently hydrogen or C<com:Sub>1-3< / com:Sub> alkyl; ring B is absent or is selected from the group consisting of a 5- to 15-membered heteroaryl ring (preferably a 6- to 12-membered heteroaryl ring, more preferably a 6- to 10-membered heteroaryl ring), a 3- to 15-membered heterocycloalkyl ring (preferably a 5- to 12-membered heterocycloalkyl ring, more preferably a 5- to 10-membered heterocycloalkyl ring), a C<com:Sub>3-15< / com:Sub> cycloalkyl ring and a C<com:Sub>6-10< / com:Sub> aryl ring (preferably a benzene ring); S<com:Sub>1< / com:Sub>, S<com:Sub>3< / com:Sub> and S<com:Sub>5< / com:Sub> are each independently selected from the group consisting of a chemical bond, -O-, - NH-, -N-, -CH<com:Sub>2< / com:Sub>-, -CH-, -C(O)-, -C(O)O-, -C(O)S-, -CH<com:Sub>2< / com:Sub>C(O)-, -CH<com:Sub>2< / com:Sub>C(S)-, -C(S)-, -CONH-, -CH=N-, - <com:Math><semantics>N=N−<annotation encoding="application / x-tex">N=N-< / annotation>< / semantics>< / com:Math>, -CH=CH-, -SO- and -SO<com:Sub>2< / com:Sub>-; S<com:Sub>2< / com:Sub> and S<com:Sub>4< / com:Sub> are each independently selected from the group consisting of -N-, -NH-, -CH- and -CH<com:Sub>2< / com:Sub>- , S<com:Sub>6< / com:Sub> is selected from the group consisting of C, -CH- and N; (R<com:Sub>B1< / com:Sub>)<com:Sub>b1< / com:Sub> represents substitution of hydrogen on ring B by b1 R<com:Sub>B1< / com:Sub>, b1 is 0, 1, 2 or 3, each R<com:Sub>B1< / com:Sub> is identical or different, and each R<com:Sub>B1< / com:Sub> is independently selected from the group consisting of X<com:Sub>2< / com:Sub>, deuterium, halogen (preferably fluorine, chlorine or bromine), cyano, carboxyl, hydroxyl, nitro, -NR<com:Sub>a1< / com:Sub>R<com:Sub>b1< / com:Sub>, C<com:Sub>1-8< / com:Sub> alkyl (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkoxy (preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, more preferably C<com:Sub>1-3< / com:Sub> alkoxy), -SC<com:Sub>1-8< / com:Sub> alkyl (preferably -SC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SC<com:Sub>1-3< / com:Sub> alkyl), -SOC<com:Sub>1-8< / com:Sub> alkyl (preferably -SOC<com:Sub>1-6< / com:Sub> alkyl, more preferably -SOC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>C<com:Sub>1-8< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, more preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-8< / com:Sub> haloalkyl (preferably C<com:Sub>1-6< / com:Sub> haloalkyl, more preferably C<com:Sub>1-3< / com:Sub> haloalkyl), C<com:Sub>1-8< / com:Sub> haloalkoxy (preferably C<com:Sub>1-6< / com:Sub> haloalkoxy, more preferably C<com:Sub>1-3< / com:Sub> haloalkoxy), amino- substituted <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl (preferably amino-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably amino-substituted <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), cyano-substituted C<com:Sub>1-8< / com:Sub> alkyl (preferably cyano-substituted C<com:Sub>1-6< / com:Sub> alkyl, more preferably cyano- substituted <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), hydroxy-substituted <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl (preferably hydroxy-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably hydroxy-substituted <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), carboxy-substituted <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyl (preferably carboxy- substituted C<com:Sub>1-6< / com:Sub> alkyl, more preferably carboxy-substituted C<com:Sub>1-3< / com:Sub> alkyl), -COC<com:Sub>1-8< / com:Sub> alkyl (preferably -COC<com:Sub>1-8< / com:Sub> 6 alkyl, more preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -COOC<com:Sub>1-8< / com:Sub> alkyl-CONR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub> (preferably -COOC<com:Sub>1-6< / com:Sub> alkyl- CONR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub>, more preferably -COOC<com:Sub>1-3< / com:Sub> alkyl-CONR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub>), -SO<com:Sub>2< / com:Sub>NR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub>, a C<com:Sub>3-15< / com:Sub> cycloalkyl ring (preferably a <com:Math><semantics>C3−10<annotation encoding="application / x-tex">C_{3-10}< / annotation>< / semantics>< / com:Math> cycloalkyl ring, more preferably a <com:Math><semantics>C3−8<annotation encoding="application / x-tex">C_{3-8}< / annotation>< / semantics>< / com:Math> cycloalkyl ring, further preferably a <com:Math><semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>< / com:Math> cycloalkyl ring), a 3- to 15-membered heterocycloalkyl ring (preferably a 4- to 12-membered heterocycloalkyl ring, more preferably a 4- to 10-membered heterocycloalkyl ring, further preferably a 4- to 8-membered heterocycloalkyl ring, further preferably a 4- to 6-membered heterocycloalkyl ring), a 5- to 10-membered heteroaryl ring (preferably a 5- to 6-membered heteroaryl ring) and a <com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl ring (preferably a benzene ring or a naphthalene ring); or two adjacent R<com:Sub>B1< / com:Sub> and carbon atom linked to the two adjacent R<com:Sub>B1< / com:Sub> together form a C<com:Sub>3-15< / com:Sub> cycloalkyl ring (preferably a C<com:Sub>3-10< / com:Sub> cycloalkyl ring, more preferably a C<com:Sub>3-8< / com:Sub> cycloalkyl ring, further preferably a C<com:Sub>3-6< / com:Sub> cycloalkyl ring), a 3- to 15-membered heterocycloalkyl ring (preferably a 4- to 12-membered heterocycloalkyl ring, more preferably a 4- to 10-membered heterocycloalkyl ring, further preferably a 4- to 8-membered heterocycloalkyl ring, further preferably a 4- to 6-membered heterocycloalkyl ring), a 5- to 6-membered heteroaryl ring or a benzene ring; the C<com:Sub>3-15< / com:Sub> cycloalkyl ring, 3- to 15-membered heterocycloalkyl ring, 5- to 6-membered heteroaryl ring or benzene ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: X<com:Sub>2< / com:Sub>, deuterium, halogen (preferably fluorine, chlorine or bromine), cyano, carboxyl, hydroxyl, nitro, -NR<com:Sub>a1< / com:Sub>R<com:Sub>b1< / com:Sub>, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, -SC<com:Sub>1-6< / com:Sub> alkyl, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, -COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -CONR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub> and -SO<com:Sub>2< / com:Sub>NR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub>; (R<com:Sub>B2< / com:Sub>)<com:Sub>b2< / com:Sub> represents substitution of hydrogen on ring C by b2 R<com:Sub>B2< / com:Sub>, b2 is 0, 1, 2, 3 or 4, each R<com:Sub>B2< / com:Sub> is identical or different, and each <com:Math><semantics>RB2<annotation encoding="application / x-tex">R_{B2}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, deuterium, halogen (preferably fluorine, chlorine or bromine), cyano, carboxyl, hydroxyl, -NR<com:Sub>a1< / com:Sub>R<com:Sub>b1< / com:Sub>, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-8< / com:Sub> 6 alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, -COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -CONR<com:Sub>a2< / com:Sub>R<com:Sub>b2< / com:Sub>, <com:Math><semantics>−OC(O)C1−6<annotation encoding="application / x-tex">-OC(O)C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl and <com:Math><semantics>−COOC1−6<annotation encoding="application / x-tex">-COOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; R<com:Sub>a1< / com:Sub>, R<com:Sub>b1< / com:Sub>, R<com:Sub>a2< / com:Sub> and R<com:Sub>b2< / com:Sub> are each independently selected from the group consisting of hydrogen, C<com:Sub>1-6< / com:Sub> alkyl, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, hydroxy-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, cyano-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, carboxy-substituted C<com:Sub>1-6< / com:Sub> alkyl, amino-substituted C<com:Sub>1-6< / com:Sub> alkyl, -COC<com:Sub>1-6< / com:Sub> alkyl and -COOC<com:Sub>1-6< / com:Sub> alkyl; X<com:Sub>2< / com:Sub> in R<com:Sub>B1< / com:Sub> and R<com:Sub>B2< / com:Sub> is a point of attachment of ULM to L or POI, and at least one of R<com:Sub>B1< / com:Sub> and R<com:Sub>B2< / com:Sub> is <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>. In some embodiments, <com:Math><semantics>RB1<annotation encoding="application / x-tex">R_{B1}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RB2<annotation encoding="application / x-tex">R_{B2}< / annotation>< / semantics>< / com:Math> are not both <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>. In some embodiments, ring B is absent. In some embodiments, the 5- to 15-membered heteroaryl ring in ring B is selected from the group consisting of a pyrrole ring, a furan ring, a thiophene ring, a pyrazole ring, an imidazole ring, a triazole ring, a tetrazole ring, an oxazole ring, a thiazole ring, an oxadiazole ring, a thiadiazole ring, a pyridine ring, a pyridazine ring, a pyrimidine ring, a pyrazine ring, a triazine ring, a benzopyrrole ring, a benzofuran ring, a benzothiophene ring, a benzopyrazole ring, a benzimidazole ring, a benzothiazole ring, a benzoxazole ring, a pyridopyrrole ring, a pyridofuran ring, a pyridothiophene ring, a pyridopyrazole ring, a pyridoimidazole ring, a pyridothiazole ring, a pyridooxazole ring, a pyrimidopyrrole ring, a pyridazopyrrole ring, a pyrazinopyrrole ring, a pyrimidopyrazole ring, a pyridazopyrazole ring, a pyrazinopyrazole ring, a pyrimidoimidazole ring, a pyridazoimidazole ring, a pyrazinoimidazole ring, a quinoline ring, an isoquinoline ring and a 9H-pyrido[2,3-b]indole ring. In some embodiments, the 5- to 15-membered heteroaryl ring in ring B is a benzopyrazole ring. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, the 3- to 15-membered heterocycloalkyl ring in ring B is , wherein Q<com:Sub>1< / com:Sub>, Q<com:Sub>2< / com:Sub>, Q<com:Sub>3< / com:Sub> and Q<com:Sub>4< / com:Sub> are each independently selected from the group consisting of -CH-, N and N-O; S<com:Sub>7< / com:Sub> and S<com:Sub>8< / com:Sub> are each independently selected from the group consisting of a chemical bond, -O-, -NH- , <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>O-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>S-, <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>C(O)-, <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>C(S)-, <com:Math><semantics>−C(S)<annotation encoding="application / x-tex">-C(S)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CONH<annotation encoding="application / x-tex">-CONH< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−CH<annotation encoding="application / x-tex">-CH< / annotation>< / semantics>< / com:Math>=N-, <com:Math><semantics>−N<annotation encoding="application / x-tex">-N< / annotation>< / semantics>< / com:Math>=N-, <com:Math><semantics>−CH2<annotation encoding="application / x-tex">-CH_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-, CH=CH-, -SO- and -SO<com:Sub>2< / com:Sub>-; represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, <com:Math><semantics>Q1<annotation encoding="application / x-tex">Q_1< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Q2<annotation encoding="application / x-tex">Q_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>Q3<annotation encoding="application / x-tex">Q_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>Q4<annotation encoding="application / x-tex">Q_4< / annotation>< / semantics>< / com:Math> are each independently -CH-. In some embodiments, S<com:Sub>7< / com:Sub> and S<com:Sub>8< / com:Sub> are each independently selected from the group consisting of - <com:Math><semantics>CH2<annotation encoding="application / x-tex">CH_2< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-. In some embodiments, <com:Math><semantics>S7<annotation encoding="application / x-tex">S_7< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>- and <com:Math><semantics>S8<annotation encoding="application / x-tex">S_8< / annotation>< / semantics>< / com:Math> is -C(O)-. In some embodiments, <com:Math><semantics>S7<annotation encoding="application / x-tex">S_7< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>S8<annotation encoding="application / x-tex">S_8< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>−C(O)<annotation encoding="application / x-tex">-C(O)< / annotation>< / semantics>< / com:Math>-. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: and [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: and ; wherein represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, the 3- to 15-membered heterocycloalkyl ring in ring B is 1 wherein ring B1 and ring B are each independently selected from the group consisting of a C<com:Sub>4-8< / com:Sub> cycloalkyl ring, a 4- to 8-membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring and a benzene ring; <com:Math><semantics>S9<annotation encoding="application / x-tex">S_9< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S10<annotation encoding="application / x-tex">S_{10}< / annotation>< / semantics>< / com:Math> are each independently selected from the group consisting of a bond, -CH<com:Sub>2< / com:Sub>- and -C(O)-; represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] , , and ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, the 3- to 15-membered heterocycloalkyl ring in ring B is [Image disponible dans le document PDF, Image available in the PDF document] ; wherein ring B3 is a 3- to 7-membered heterocycloalkyl, represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, ring B3 is a 5- to 7-membered nitrogen-containing heterocycloalkyl ring. In some embodiments, ring B3 is a partially unsaturated 5- to 7-membered nitrogen-containing heterocycloalkyl ring. In some embodiments, ring B3 is selected from the group consisting of 2,5-dihydro-1H-pyrrole, 2,3-dihydro-1H-pyrrole, 1,2,3,6-tetrahydropyridine, 1,2,3,4-tetrahydropyridine, 2,3,6,7-tetrahydro-1H- azepine, 2,3,4,7-tetrahydro-1H-azepine and 2,3,4,5-tetrahydro-1H-azepine. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] and ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, ring B is selected from the group consisting of: a benzene ring, [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, ring B is selected from the group consisting of: a benzene ring, [Image disponible dans le document PDF, Image available in the PDF document] 9 ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, ring B is selected from the group consisting of: and [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, each <com:Math><semantics>RB1<annotation encoding="application / x-tex">R_{B1}< / annotation>< / semantics>< / com:Math> is independently <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, deuterium, fluorine, chlorine, bromine, cyano, carboxyl, hydroxyl, nitro, -NH<com:Sub>2< / com:Sub>, -N(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -NHCH<com:Sub>3< / com:Sub>, -NHCOCH<com:Sub>3< / com:Sub>, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, trifluoromethyl, difluoromethyl, monofluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, -SCH<com:Sub>3< / com:Sub>, -SOCH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, - <com:Math><semantics>(CH2)3NH2<annotation encoding="application / x-tex">(CH_2)_3NH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2CN<annotation encoding="application / x-tex">-CH_2CN< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2CN<annotation encoding="application / x-tex">-(CH_2)_2CN< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3CN<annotation encoding="application / x-tex">-(CH_2)_3CN< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2OH<annotation encoding="application / x-tex">-CH_2OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)2OH<annotation encoding="application / x-tex">-(CH_2)_2OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2COOH<annotation encoding="application / x-tex">-CH_2COOH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH2)3OH<annotation encoding="application / x-tex">-(CH_2)_3OH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−(CH<annotation encoding="application / x-tex">-(CH< / annotation>< / semantics>< / com:Math> (CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>COOH, -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>COOH, -COCH<com:Sub>3< / com:Sub>, -COCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -COOCH<com:Sub>3< / com:Sub>, -COOCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CONH<com:Sub>2< / com:Sub> or - SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>; or two adjacent R<com:Sub>B1< / com:Sub> and carbon atom linked to the two adjacent R<com:Sub>B1< / com:Sub> together form a cyclobutyl ring, a cyclopentyl ring, a cyclohexyl ring, a cycloheptyl ring, a cyclopentene ring, a cyclohexene ring, a cycloheptene ring, a tetrahydropyrrole ring, a tetrahydrofuran ring, a tetrahydrothiophene ring, a piperidine ring, a pyrazine ring, a 1,2,3,4-tetrahydropyridine ring, a 1,2,3,4-tetrahydropyran ring, a 3,4- dihydro-2H-1,4-oxazine ring, a 2,3,4,5-tetrahydro-1H-azepine ring, a pyrrole ring, a pyrazole ring, an oxazole ring, a thiazole ring, a pyran ring, a pyridine ring, a pyridazine ring, a pyrimidine ring or a benzene ring; wherein the cyclobutyl ring, cyclopentyl ring, cyclohexyl ring, cyclohexyl ring, cyclopentene ring, cyclohexene ring, cycloheptene ring, tetrahydropyrrole ring, tetrahydrofuran ring, tetrahydrothiophene ring, piperidine ring, pyrazine ring, 1,2,3,4-tetrahydropyridine ring, 1,2,3,4- tetrahydropyran ring, 3,4-dihydro-2H-1,4-oxazine ring, 2,3,4,5-tetrahydro-1H-azepine ring, pyrrole ring, pyrazole ring, oxazole ring, thiazole ring, pyran ring, pyridine ring, pyridazine ring, pyrimidine ring or benzene ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: X<com:Sub>2< / com:Sub>, deuterium, fluorine, chlorine, bromine, cyano, carboxyl, hydroxyl, nitro, amino, methyl, trifluoromethyl, methoxy, trifluoromethoxy, -SCH<com:Sub>3< / com:Sub>, -SOCH<com:Sub>3< / com:Sub>, -SO<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -COCH<com:Sub>3< / com:Sub>, -COCH<com:Sub>3< / com:Sub>, - CONH<com:Sub>2< / com:Sub> and -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>. In some embodiments, <com:Math><semantics>RB1<annotation encoding="application / x-tex">R_{B1}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, fluorine, chlorine, hydroxyl, methyl, trifluoromethyl and methoxy. In some embodiments, b1 is 1, and <com:Math><semantics>RB1<annotation encoding="application / x-tex">R_{B1}< / annotation>< / semantics>< / com:Math> is fluorine. In some embodiments, b1 is 1, and R<com:Sub>B1< / com:Sub> is methyl. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of: <com:Math><semantics>N−N<annotation encoding="application / x-tex">N-N< / annotation>< / semantics>< / com:Math> <com:Math><semantics>N−N<annotation encoding="application / x-tex">N-N< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] Xz <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> , , and , wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI, <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and , wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI, <com:Math><semantics>→<annotation encoding="application / x-tex">\longrightarrow< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math> is a chemical bond. In some embodiments, <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math> is -NH-. In some embodiments, U<com:Sub>0< / com:Sub> is -CONH-. In some embodiments, <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math> is -CH<com:Sub>2< / com:Sub>-. In some embodiments, <com:Math><semantics>S1<annotation encoding="application / x-tex">S_1< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S3<annotation encoding="application / x-tex">S_3< / annotation>< / semantics>< / com:Math> are -C(O)-, <com:Math><semantics>S2<annotation encoding="application / x-tex">S_2< / annotation>< / semantics>< / com:Math> is -NH-, and <com:Math><semantics>S4<annotation encoding="application / x-tex">S_4< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>S5<annotation encoding="application / x-tex">S_5< / annotation>< / semantics>< / com:Math> are -CH<com:Sub>2< / com:Sub>-. In some embodiments, S<com:Sub>6< / com:Sub> is -CH-. In some embodiments, <com:Math><semantics>S6<annotation encoding="application / x-tex">S_6< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>N<annotation encoding="application / x-tex">N< / annotation>< / semantics>< / com:Math>. In some embodiments, b2 is 0. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structure or an isomer thereof: <com:Math><semantics>(RB2)b2<annotation encoding="application / x-tex">(R_{B2})_{b2}< / annotation>< / semantics>< / com:Math>; wherein <com:Math><semantics>∼<annotation encoding="application / x-tex">\sim< / annotation>< / semantics>< / com:Math> represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 5 structures or isomers thereof: and ; wherein represents a covalent connection to <com:Math><semantics>U0<annotation encoding="application / x-tex">U_0< / annotation>< / semantics>< / com:Math>. In some embodiments, ULM is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] V [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] isomers thereof: , , , 9 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is selected from the group consisting of the following structure or an [Image disponible dans le document PDF, Image available in the PDF document] isomer thereof: ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] isomers thereof: , and ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is a structure of formula (U-2) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(U−2),<annotation encoding="application / x-tex">(U-2),< / annotation>< / semantics>< / com:Math> wherein, rl is 0, 1 or 2; ring D is selected from the group consisting of a benzene ring, a 5- to 6-membered heteroaryl ring, a C<com:Sub>3-10< / com:Sub> cycloalkyl ring (preferably a C<com:Sub>3-8< / com:Sub> cycloalkyl ring, more preferably a C<com:Sub>3-6< / com:Sub> cycloalkyl ring) and a 3- to 10-membered heterocycloalkyl ring (preferably a 3- to 8-membered heterocycloalkyl ring, more preferably a 3- to 6-membered heterocycloalkyl ring); (R<com:Sub>U2< / com:Sub>)<com:Sub>r2< / com:Sub> represents substitution of hydrogen on ring D by r2 R<com:Sub>U2< / com:Sub>, r2 is 0, 1, 2 or 3, each R<com:Sub>U2< / com:Sub> is identical or different, and each <com:Math><semantics>RU2<annotation encoding="application / x-tex">R_{U2}< / annotation>< / semantics>< / com:Math> is independently selected from the group consisting of <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, halogen (preferably fluorine, chlorine), nitro, cyano, carboxyl, hydroxyl, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> alkoxy C<com:Sub>1-6< / com:Sub> alkyl, hydroxy-substituted C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, -NR<com:Sub>a3< / com:Sub>R<com:Sub>b3< / com:Sub>, - COC<com:Sub>1-6< / com:Sub> alkyl, -COOC<com:Sub>1-6< / com:Sub> alkyl, -OCOC<com:Sub>1-6< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl, -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SOC<com:Sub>1-6< / com:Sub> 6 alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl, -SC<com:Sub>1-6< / com:Sub> alkyl, 5- to 6-membered heteroaryl and phenyl; the 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, C<com:Sub>1-6< / com:Sub> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkyl), hydroxy-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl (preferably hydroxy-substituted <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkoxy C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably C<com:Sub>1-3< / com:Sub> alkoxy), C<com:Sub>1-6< / com:Sub> haloalkyl (preferably C<com:Sub>1-3< / com:Sub> haloalkyl), C<com:Sub>1-6< / com:Sub> haloalkoxy (preferably C<com:Sub>1-3< / com:Sub> haloalkoxy), -NH<com:Sub>2< / com:Sub>, -NHCOC<com:Sub>1-6< / com:Sub> alkyl (preferably -NHCOC<com:Sub>1-8< / com:Sub> 3 alkyl), -COC<com:Sub>1-6< / com:Sub> alkyl (preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -COOC<com:Sub>1-6< / com:Sub> alkyl (preferably -COOC<com:Sub>1-3< / com:Sub> alkyl), - OCOC<com:Sub>1-6< / com:Sub> alkyl (preferably -OCOC<com:Sub>1-3< / com:Sub> alkyl), -CONH<com:Sub>2< / com:Sub>, -NHCONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl (preferably - CONHC<com:Sub>1-3< / com:Sub> alkyl), -NHCONHC<com:Sub>1-6< / com:Sub> alkyl (preferably -NHCONHC<com:Sub>1-3< / com:Sub> alkyl), -SOC<com:Sub>1-6< / com:Sub> alkyl (preferably - SOC<com:Sub>1-3< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> alkyl (preferably -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> alkyl) and -SC<com:Sub>1-6< / com:Sub> alkyl (preferably -SC<com:Sub>1-3< / com:Sub> alkyl); [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>U1<annotation encoding="application / x-tex">U_1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of the following structures or isomers thereof: <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, -NHCO- [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, -NHCOCH<com:Sub>3< / com:Sub>, , a 5- to 6-membered heteroaryl ring, , the [Image disponible dans le document PDF, Image available in the PDF document] 5- to 6-membered heteroaryl ring, are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: X<com:Sub>2< / com:Sub>, halogen, hydroxyl, cyano, amino, carboxyl, C<com:Sub>1-6< / com:Sub> alkyl (preferably methyl, ethyl, isopropyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably methoxy, ethoxy, isopropoxy), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably trifluoromethyl), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably trifluoromethoxy), -COC<com:Sub>1-6< / com:Sub> alkyl (preferably -COCH<com:Sub>3< / com:Sub>), -COOC<com:Sub>1-6< / com:Sub> alkyl (preferably -COOCH<com:Sub>3< / com:Sub>), -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl (preferably -CONHCH<com:Sub>3< / com:Sub>), -CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub> (preferably -CON(<com:Math><semantics>CH3<annotation encoding="application / x-tex">CH_3< / annotation>< / semantics>< / com:Math>)<com:Sub>2< / com:Sub>) and hydroxy-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl (preferably -CH<com:Sub>2< / com:Sub>OH); R<com:Sub>Ua< / com:Sub> is selected from the group consisting of hydrogen, halogen (preferably fluorine, chlorine or bromine), cyano, hydroxyl, carboxyl, amino, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, - <com:Math><semantics>COC1−6<annotation encoding="application / x-tex">COC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, -NHCOC<com:Sub>1-6< / com:Sub> alkyl, -N(C<com:Sub>1-6< / com:Sub> alkyl)COC<com:Sub>1-6< / com:Sub> alkyl, -NHC<com:Sub>1-6< / com:Sub> alkyl and -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>; R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, C<com:Sub>1-6< / com:Sub> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably C<com:Sub>1-3< / com:Sub> alkoxy), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl (preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkoxy) and <com:Math><semantics>−SC1−6<annotation encoding="application / x-tex">-SC_{1-6}< / annotation>< / semantics>< / com:Math> 6 alkyl (preferably -SC<com:Sub>1-3< / com:Sub> alkyl); or R<com:Sub>U3< / com:Sub>, R<com:Sub>U4< / com:Sub> and carbon atom linked to R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> together form a C<com:Sub>3-< / com:Sub> <com:Sup>7< / com:Sup> cycloalkyl (preferably C<com:Sub>3-6< / com:Sub> cycloalkyl) and a 3- to 7-membered heterocycloalkyl (preferably a 4- to 6- membered heterocycloalkyl); wherein the C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, -SC<com:Sub>1-6< / com:Sub> 6 alkyl, C<com:Sub>3-7< / com:Sub> cycloalkyl and 3- to 7-membered heterocycloalkyl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: X<com:Sub>2< / com:Sub>, halogen (preferably fluorine, chlorine or bromine), cyano, carboxyl and hydroxy; <com:Math><semantics>RU5<annotation encoding="application / x-tex">R_{U5}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RU6<annotation encoding="application / x-tex">R_{U6}< / annotation>< / semantics>< / com:Math> are each independently selected from the group consisting of <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>, hydrogen, deuterium, halogen, amino, cyano, carboxyl, hydroxyl, C<com:Sub>1-6< / com:Sub> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably C<com:Sub>1< / com:Sub>- 3 alkoxy), C<com:Sub>1-6< / com:Sub> haloalkyl (preferably C<com:Sub>1-3< / com:Sub> haloalkyl), C<com:Sub>1-6< / com:Sub> haloalkoxy (C<com:Sub>1-3< / com:Sub> haloalkoxy), -SC<com:Sub>1-6< / com:Sub> alkyl (preferably -SC<com:Sub>1-3< / com:Sub> alkyl), CONHC<com:Sub>1-6< / com:Sub> alkyl-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, CON(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, carboxyl-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl and <com:Math><semantics>COOC1−6<annotation encoding="application / x-tex">COOC_{1-6}< / annotation>< / semantics>< / com:Math> alkyl-substituted <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl; R<com:Sub>U7< / com:Sub> is selected from the group consisting of hydrogen, C<com:Sub>1-6< / com:Sub> alkyl, and C<com:Sub>1-6< / com:Sub> haloalkyl; or R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a 3- to 8-membered heterocycloalkyl ring or a 5- to 6-membered heteroaryl ring; <com:Math><semantics>RU8<annotation encoding="application / x-tex">R_{U8}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of hydroxyl, amino, -NH(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl), -N(<com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>, <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> 6 alkoxy, C<com:Sub>1-6< / com:Sub> haloalkoxy and -OCOC<com:Sub>1-6< / com:Sub> alkyl; R<com:Sub>a3< / com:Sub> and R<com:Sub>b3< / com:Sub> are each independently selected from the group consisting of hydrogen, C<com:Sub>1-6< / com:Sub> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably C<com:Sub>1-3< / com:Sub> alkoxy), -SC<com:Sub>1-6< / com:Sub> alkyl (preferably -SC<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> haloalkyl (preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl), <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkoxy (preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkoxy), -COC<com:Sub>1-6< / com:Sub> alkyl (preferably -COC<com:Sub>1-3< / com:Sub> alkyl), -CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl (preferably -CONHC<com:Sub>1-3< / com:Sub> alkyl), -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -CON(<com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl)<com:Sub>2< / com:Sub>), 5- to 6-membered heteroaryl and phenyl; wherein the 5- to 6- membered heteroaryl and phenyl are each independently unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: hydrogen, C<com:Sub>1-6< / com:Sub> alkyl (preferably C<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> alkoxy (preferably C<com:Sub>1-3< / com:Sub> alkoxy), -SC<com:Sub>1-6< / com:Sub> alkyl (preferably -SC<com:Sub>1-3< / com:Sub> alkyl), C<com:Sub>1-6< / com:Sub> haloalkyl (preferably C<com:Sub>1-3< / com:Sub> haloalkyl), C<com:Sub>1-6< / com:Sub> haloalkoxy (preferably C<com:Sub>1-3< / com:Sub> haloalkoxy), -COC<com:Sub>1-6< / com:Sub> alkyl (preferably -COC<com:Sub>1-3< / com:Sub> alkyl), - CONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-6< / com:Sub> alkyl (preferably -CONHC<com:Sub>1-3< / com:Sub> alkyl) and -CON(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub> (preferably -CON(C<com:Sub>1-3< / com:Sub> alkyl)<com:Sub>2< / com:Sub>); X<com:Sub>2< / com:Sub> in R<com:Sub>U2< / com:Sub>, R<com:Sub>U1< / com:Sub>, R<com:Sub>U5< / com:Sub> and R<com:Sub>U6< / com:Sub> is the point of attachment of ULM to L or POI, and at least one of R<com:Sub>U1< / com:Sub>, <com:Math><semantics>RU5<annotation encoding="application / x-tex">R_{U5}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>RU6<annotation encoding="application / x-tex">R_{U6}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RU2<annotation encoding="application / x-tex">R_{U2}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>. In some embodiments, r1 is 0. In some embodiments, r1 is 1. In some embodiments, r1 is 2. In some embodiments, ring D is selected from the group consisting of a benzene ring, a 5- to 6- membered heteroaryl ring, a C<com:Sub>5-9< / com:Sub> cycloalkyl ring and a 5- to 9-membered heterocycloalkyl ring. In some embodiments, ring D is selected from the group consisting of a benzene ring and 2,3- dihydro-1H-indene. In some embodiments, ring D is a benzene ring. In some embodiments, ring D is 2,3-dihydro-1H-indene. In some embodiments, ring D is selected from the group consisting of a benzene ring and a 5- to 6- membered heteroaryl ring. In some embodiments, ring D is selected from the group consisting of a benzene ring, a pyrrole ring, a thiophene ring, a furan ring, a pyrazole ring, an imidazole ring, a triazole ring, a thiazole ring, an oxazole ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, a cyclohexane ring, a piperidine ring, a piperazine ring and a tetrahydropyrrole ring. In some embodiments, ring D is selected from the group consisting of a benzene ring and a pyridine ring. In some embodiments, r1 is 0, and ring D is 2,3-dihydro-1H-indene. In some embodiments, r1 is 1, and ring D is a benzene ring. In some embodiments, r2 is 0. 5 In some embodiments, r2 is 1. In some embodiments, r2 is 2. In some embodiments, R<com:Sub>U2< / com:Sub> is 5- to 6-membered heteroaryl or phenyl, the 5- to 6-membered heteroaryl or phenyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: deuterium, halogen (preferably fluorine, chlorine), cyano, carboxyl, hydroxyl, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkyl, C<com:Sub>1-3< / com:Sub> haloalkoxy, -NH<com:Sub>2< / com:Sub>, -NHCOC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-3< / com:Sub> alkyl, -COC<com:Sub>1-< / com:Sub> OCOC<com:Sub>1-3< / com:Sub> alkyl, -CONH<com:Sub>2< / com:Sub>, -NHCONH<com:Sub>2< / com:Sub>, -CONHC<com:Sub>1-3< / com:Sub> alkyl, -NHCONHC<com:Sub>1-3< / com:Sub> alkyl, -SOC<com:Sub>1-3< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-3< / com:Sub> 3 alkyl and -SC<com:Sub>1-3< / com:Sub> alkyl. In some embodiments, the 5- to 6-membered heteroaryl is selected from the group consisting of thiazolyl, oxazolyl, pyrazolyl, imidazolyl, pyrrolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, tetrazolyl and triazolyl. In some embodiments, the 5- to 6-membered heteroaryl is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, the 5- to 6-membered heteroaryl is In some embodiments, the 5- to 6-membered heteroaryl ring is selected from the group consisting of a thiazole ring, an oxazole ring, a pyrazole ring, an imidazole ring, a pyrrole ring, a pyridine ring, a pyrimidine ring, a pyridazine ring, a pyrazine ring, a tetrazole ring and a triazole ring. In some embodiments, R<com:Sub>U2< / com:Sub> is cyano. In some embodiments, R<com:Sub>a3< / com:Sub> and R<com:Sub>b3< / com:Sub> are each independently selected from the group consisting of hydrogen, 5- to 6-membered heteroaryl and phenyl; the 5- to 6-membered heteroaryl is selected from 25 the group consisting of thiazolyl, oxazolyl, pyrazolyl, imidazolyl, thienyl, furyl, pyrrolyl, triazolyl and tetrazolyl; the 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of: hydrogen, methyl, ethyl, isopropyl, trifluoromethyl, trifluoromethoxy, -COCH<com:Sub>3< / com:Sub> and -CONH<com:Sub>2< / com:Sub>. In some embodiments, R<com:Sub>U2< / com:Sub> is -NHR<com:Sub>a3< / com:Sub>, wherein R<com:Sub>a3< / com:Sub> is 5- to 6-membered heteroaryl or phenyl, and the 5- to 6-membered heteroaryl is selected from the group consisting of thiazolyl, imidazolyl, pyrazolyl, oxazolyl, pyridinyl and pyrimidinyl; wherein the 5- to 6-membered heteroaryl or phenyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of: C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkoxy, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> haloalkyl, -SC<com:Sub>1-3< / com:Sub> alkyl and -OCOC<com:Sub>1-3< / com:Sub> alkyl. In some embodiments, R<com:Sub>U2< / com:Sub> is -NHR<com:Sub>a3< / com:Sub>, wherein R<com:Sub>a3< / com:Sub> is thiazolyl; and the thiazolyl is substituted with 1, 2 or 3 substituents selected from the group consisting of: methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, propoxy, isopropoxy, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy and trifluoroethoxy. In some embodiments, R<com:Sub>U2< / com:Sub> is -NHR<com:Sub>a3< / com:Sub>, wherein R<com:Sub>a3< / com:Sub> is thiazolyl; and the thiazolyl is substituted with 1, 2 or 3 substituents selected from the group consisting of: methyl, ethyl, propyl and isopropyl. In some embodiments, R<com:Sub>U2< / com:Sub> is selected from the group consisting of following structure: cyano, N HN N N N N [Image disponible dans le document PDF, Image available in the PDF document] and [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, r2 is 1, and <com:Math><semantics>RU2<annotation encoding="application / x-tex">R_{U2}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of cyano, [Image disponible dans le document PDF, Image available in the PDF document] . [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, r2 is 1, and R<com:Sub>U2< / com:Sub> is [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, r2 is 2, and <com:Math><semantics>RU2<annotation encoding="application / x-tex">R_{U2}< / annotation>< / semantics>< / com:Math> are <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> and , respectively. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: , , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> and ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structure or an isomer thereof: In some embodiments, one of <com:Math><semantics>RU1<annotation encoding="application / x-tex">R_{U1}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>RU5<annotation encoding="application / x-tex">R_{U5}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>RU6<annotation encoding="application / x-tex">R_{U6}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RU2<annotation encoding="application / x-tex">R_{U2}< / annotation>< / semantics>< / com:Math> is <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math>. In some embodiments, R<com:Sub>Ua< / com:Sub> is selected from the group consisting of fluorine, cyano, methyl, ethyl, trifluoromethyl and trifluoromethoxy. In some embodiments, <com:Math><semantics>RUa<annotation encoding="application / x-tex">R_{Ua}< / annotation>< / semantics>< / com:Math> is selected from the group consisting of fluorine and cyano. In some embodiments, U<com:Sub>1< / com:Sub> is selected from the group consisting of X<com:Sub>2< / com:Sub>, -NHCO-X<com:Sub>2< / com:Sub>, -NHCOCH<com:Sub>3< / com:Sub>, [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, <com:Math><semantics>U1<annotation encoding="application / x-tex">U_1< / annotation>< / semantics>< / com:Math> is selected from the group consisting of -NHCO-<com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> and wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> are each independently hydrogen, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1< / com:Sub>- 6 alkoxy or C<com:Sub>1-6< / com:Sub> haloalkoxy; or R<com:Sub>U3< / com:Sub>, R<com:Sub>U4< / com:Sub> and carbon atom linked to R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> form a C<com:Sub>3-6< / com:Sub> cycloalkyl ring. In some embodiments, R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> are each independently hydrogen, -CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -C(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -CHF<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -OCH<com:Sub>3< / com:Sub>, -OCH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>, -OC(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>, -OCF<com:Sub>3< / com:Sub>, -OCHF<com:Sub>2< / com:Sub>, -OCH<com:Sub>2< / com:Sub>F, fluoro- substituted isopropyl or fluoro-substituted tert-butyl; or R<com:Sub>U3< / com:Sub>, R<com:Sub>U4< / com:Sub> and carbon atom linked to R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> form a cyclopropyl ring, a cyclobutyl ring, a cyclopentyl ring or a cyclohexyl ring. In some embodiments, R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> are each independently hydrogen, -CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, - CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub> or -C(CH<com:Sub>3< / com:Sub>)<com:Sub>3< / com:Sub>; or R<com:Sub>U3< / com:Sub>, R<com:Sub>U4< / com:Sub> and carbon atom linked to R<com:Sub>U3< / com:Sub> and R<com:Sub>U4< / com:Sub> form a cyclopropyl ring. In some embodiments, <com:Math><semantics>RU3<annotation encoding="application / x-tex">R_{U3}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RU4<annotation encoding="application / x-tex">R_{U4}< / annotation>< / semantics>< / com:Math> are each independently hydrogen, <com:Math><semantics>−CH(CH3)2<annotation encoding="application / x-tex">-CH(CH_3)_2< / annotation>< / semantics>< / com:Math> or <com:Math><semantics>−C(CH3)3<annotation encoding="application / x-tex">-C(CH_3)_3< / annotation>< / semantics>< / com:Math>. In some embodiments, R<com:Sub>U1< / com:Sub> is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] or POI. In some embodiments, R<com:Sub>U1< / com:Sub> is selected from the group consisting of the following structures: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, R<com:Sub>U1< / com:Sub> is selected from the group consisting of the following structure: [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, R<com:Sub>U5< / com:Sub> and R<com:Sub>U6< / com:Sub> are each independently X<com:Sub>2< / com:Sub>, hydrogen, deuterium, halogen, hydroxyl, carboxyl, cyano, amino, C<com:Sub>1-3< / com:Sub> alkyl, C<com:Sub>1-3< / com:Sub> alkoxy, C<com:Sub>1-3< / com:Sub> haloalkyl or C<com:Sub>1-3< / com:Sub> haloalkoxy; or R<com:Sub>U5< / com:Sub> and carbon atom on ring D together form a C<com:Sub>3-6< / com:Sub> cycloalkyl ring; wherein the C<com:Sub>3-6< / com:Sub> cycloalkyl ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: deuterium, halogen (preferably fluorine, chlorine or bromine), cyano, carboxyl, hydroxyl, nitro, formyl, sulfo, -NH<com:Sub>2< / com:Sub>, -NH(C<com:Sub>1-6< / com:Sub> alkyl), -N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, C<com:Sub>1-6< / com:Sub> alkyl, C<com:Sub>1-6< / com:Sub> alkoxy, -SC<com:Sub>1-6< / com:Sub> alkyl, -SOC<com:Sub>1-6< / com:Sub> alkyl, -SO<com:Sub>2< / com:Sub>C<com:Sub>1-6< / com:Sub> 6 alkyl, C<com:Sub>1-6< / com:Sub> haloalkyl, C<com:Sub>1-6< / com:Sub> haloalkoxy, amino-substituted C<com:Sub>1-6< / com:Sub> alkyl, cyano-substituted C<com:Sub>1-6< / com:Sub> alkyl, hydroxy-substituted C<com:Sub>1-6< / com:Sub> alkyl, carboxyl-substituted C<com:Sub>1-6< / com:Sub> alkyl, -COC<com:Sub>1-6< / com:Sub> alkyl, -CO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -CO<com:Sub>2< / com:Sub>NH(C<com:Sub>1-6< / com:Sub> alkyl), -CO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NH<com:Sub>2< / com:Sub>, -SO<com:Sub>2< / com:Sub>NH(C<com:Sub>1-6< / com:Sub> alkyl), -SO<com:Sub>2< / com:Sub>N(C<com:Sub>1-6< / com:Sub> alkyl)<com:Sub>2< / com:Sub>, a C<com:Sub>3-8< / com:Sub> cycloalkyl ring, a 4- to 10-membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring and a benzene ring. In some embodiments, <com:Math><semantics>RU5<annotation encoding="application / x-tex">R_{U5}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>RU6<annotation encoding="application / x-tex">R_{U6}< / annotation>< / semantics>< / com:Math> are each independently hydrogen, <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl or <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> haloalkyl. In some embodiments, R<com:Sub>U5< / com:Sub> and R<com:Sub>U6< / com:Sub> are each independently hydrogen, -CH<com:Sub>3< / com:Sub>, -OCH<com:Sub>3< / com:Sub>, -CF<com:Sub>3< / com:Sub>, -OCF<com:Sub>3< / com:Sub>, -CHF<com:Sub>2< / com:Sub>, -CH<com:Sub>2< / com:Sub>F, -OCHF<com:Sub>2< / com:Sub> or -OCH<com:Sub>2< / com:Sub>F. In some embodiments, R<com:Sub>U5< / com:Sub> and R<com:Sub>U6< / com:Sub> are each independently hydrogen or -CH<com:Sub>3< / com:Sub>. In some embodiments, R<com:Sub>U7< / com:Sub> is selected from the group consisting of hydrogen, methyl, ethyl, monofluoromethyl, difluoromethyl and trifluoromethyl. In some embodiments, R<com:Sub>U7< / com:Sub> is hydrogen. In some embodiments, R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a partially unsaturated 3- to 8-membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring 25 or a benzene ring. In some embodiments, R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a tetrahydropyrrole ring, a pyrazolidine ring, an imidazolidine ring, a piperazine ring, a piperidine ring, a 2,3-dihydro-1H-pyrrole ring, a 2,3-dihydro-1H-pyrazole ring, a pyrrole ring, a pyrazole ring, an imidazole ring, a pyridine ring, a pyrimidine ring or a benzene ring. In some embodiments, R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a 4- to 6-membered heterocycloalkyl ring. In some embodiments, R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a 5-membered heterocycloalkyl ring. In some embodiments, R<com:Sub>U7< / com:Sub>, nitrogen atom linked to R<com:Sub>U7< / com:Sub>, R<com:Sub>U6< / com:Sub> and carbon atom linked to R<com:Sub>U6< / com:Sub> together form a tetrahydropyrrole ring. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: , , , [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] structures or isomers thereof: In some embodiments, R<com:Sub>U8< / com:Sub> is selected from the group consisting of hydroxyl, amino, -NH(C<com:Sub>1-3< / com:Sub> alkyl), <com:Math><semantics>−N(C1−3 alkyl)2<annotation encoding="application / x-tex">-N(C_{1-3} \text{ alkyl})_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>C1−3 alkoxy<annotation encoding="application / x-tex">C_{1-3} \text{ alkoxy}< / annotation>< / semantics>< / com:Math>, fluoro <com:Math><semantics>C1−3 alkoxy<annotation encoding="application / x-tex">C_{1-3} \text{ alkoxy}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−OCOC1−3 alkyl<annotation encoding="application / x-tex">-OCOC_{1-3} \text{ alkyl}< / annotation>< / semantics>< / com:Math>. In some embodiments, R<com:Sub>U8< / com:Sub> is selected from the group consisting of hydroxyl, amino, -NH(CH<com:Sub>3< / com:Sub>), - <com:Math><semantics>N(CH3)2<annotation encoding="application / x-tex">N(CH_3)_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OCH3<annotation encoding="application / x-tex">-OCH_3< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−OCF3<annotation encoding="application / x-tex">-OCF_3< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>−OCOCH3<annotation encoding="application / x-tex">-OCOCH_3< / annotation>< / semantics>< / com:Math>. In some embodiments, R<com:Sub>U8< / com:Sub> is hydroxyl. In some embodiments, ULM is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ___11___ wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, ULM is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] isomers thereof: and [Image disponible dans le document PDF, Image available in the PDF document] ; wherein <com:Math><semantics>X2<annotation encoding="application / x-tex">X_2< / annotation>< / semantics>< / com:Math> is the point of attachment of ULM to L or POI. In some embodiments, the compound of formula (I) is a structure of formula (I-A), [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>(I−A)<annotation encoding="application / x-tex">(I-A)< / annotation>< / semantics>< / com:Math> , wherein, ring A1, ring A2, R1, n1, R2, n2, R3, n3, L, n0 and ULM are as defined in the specification, and both <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> are not <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, the compound of formula (I) is a structure of formula (I-B), [Image disponible dans le document PDF, Image available in the PDF document] (I-B) , wherein, ring A1, ring A2, R1, n1, R2, n2, R3, n3, L, n0 and ULM are as defined in the specification, and both <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> are not <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein, ring A2, R1, n1, R2, n2, R3, n3, L, n0 and ULM are as defined in the specification, and both <com:Math><semantics>R2<annotation encoding="application / x-tex">R_2< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>R3<annotation encoding="application / x-tex">R_3< / annotation>< / semantics>< / com:Math> are not <com:Math><semantics>X1<annotation encoding="application / x-tex">X_1< / annotation>< / semantics>< / com:Math>. In some embodiments, the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−46−<annotation encoding="application / x-tex">-46-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 1 Λ <com:Math><semantics>−47−<annotation encoding="application / x-tex">-47-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 1 1 Λ <com:Math><semantics>−48−<annotation encoding="application / x-tex">-48-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] wherein, L, n0 and ULM are as defined in the specification. In some embodiments, the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] and wherein, L, n0 and ULM are as defined in the specification. In some embodiments, the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] .M ; wherein, L, n0 and ULM are as defined in the specification. In some embodiments, the compound of formula (I) is selected from the group consisting of the 5 following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein, L, n0, and ULM are as defined in the specification. In some embodiments, the compound of formula (I) is a specific compound selected from the Examples. In some embodiments, the compound of formula (I) is a compound selected from Table A or a stereoisomer thereof: Table A [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−54−<annotation encoding="application / x-tex">-54-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments, the compound of formula (I) is a compound selected from Table B or a stereoisomer thereof: Table B [Image disponible dans le document PDF, Image available in the PDF document] <com:Math><semantics>−56−<annotation encoding="application / x-tex">-56-< / annotation>< / semantics>< / com:Math> [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] # 88 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 8 3 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] A second aspect of the present application provides a pharmaceutical composition, comprising the compound of formula (I) according to the first aspect of the present application, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof; and a pharmaceutically acceptable carrier. A third aspect of the present application provides use of the compound of formula (I) according to the first aspect of the present application, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or the pharmaceutical composition according to the second aspect of the present application, in the manufacture of a medicament for preventing and / or treating an EED-mediated disease. In some embodiments, the EED-mediated disease is a tumor or an autoimmune disease. In some embodiments, the EED-mediated disease is cancer. In some embodiments, the cancer is selected from the group consisting of multiple myeloma, leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer. A fourth aspect of the present application provides a method for preventing and / or treating an EED- mediated disease, comprising administering a therapeutically effective amount of the compound of formula (I) according to the first aspect of the present application, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or the pharmaceutical composition according to the second aspect of the present application to a subject. In some embodiments, the EED-mediated disease is a tumor or an autoimmune disease. In some embodiments, the EED-mediated disease is cancer. In some embodiments, the cancer is selected from the group consisting of multiple myeloma, leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer. BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings described herein are intended to provide a further understanding of the present application and constitute a part of the present application. The schematic embodiments and descriptions thereof in the present application are intended to explain the present application and do not constitute an undue limitation on the present application. FIG. 1 is a graph showing the in vivo antitumor activity results of Compound D1 and Compound H105; FIG. 2 is a graph showing the effect of Compound D1 and Compound H105 on mouse body weight. DETAILED DESCRIPTION After extensive and in-depth research, the present inventors have unexpectedly discovered a bifunctional compound targeting degradation and / or inhibition of EED protein. This compound exhibits excellent EED protein degradation activity, excellent tumor cell (such as wsuDLCL-2 cells, Pfeiffer cells, etc.) proliferation inhibitory activity, excellent pharmacokinetic properties, excellent CYP450 profile, and good safety, making it more suitable for the treatment of diseases or conditions associated with abnormal EED protein activity (such as proliferative diseases like cancer). Based on this, the inventors have completed the present application. Definition of Terms In order to more clearly understand the technical content of the present application, the terms of the present application are further described below. The present application provides a bifunctional compound or PROTAC compound, which has a structure of POI—ULM or a structure of POI—L—ULM, wherein POI is a ligand targeting EED protein (or a ligand that binds to EED protein), ULM is an E3 ligase binding group (or a binding group), and L is a linker connecting POI and ULM. The PROTAC compound can bind to EED protein through the POI moiety, thereby bringing EED protein into proximity with an E3 ligase, thus inducing degradation (and / or inhibition) of EED protein. Commonly used E3 ligase ligands include VHL (Von Hippel-Lindau) E3 ubiquitin ligase binding group (abbreviated as VLM), CRBN (cereblon) E3 ubiquitin ligase binding group (abbreviated as CLM), MDM2 (mouse double minute 2 homologue) E3 ubiquitin ligase binding group (abbreviated as MLM), cIAP (cellular inhibitor of apoptosis) E3 ubiquitin ligase binding group (abbreviated as ILM), and the like. POI is a ligand targeting EED protein and can bind to EED protein. 5 "Alkyl" refers to linear and branched saturated aliphatic hydrocarbon groups. "C<com:Sub>1-10< / com:Sub> alkyl" refers to an alkyl group having 1 to 10 carbon atoms, preferably C<com:Sub>1-8< / com:Sub> alkyl; more preferably C<com:Sub>1-6< / com:Sub> alkyl; further preferably C<com:Sub>1-3< / com:Sub> alkyl. Non-limiting examples of alkyl include: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1- ethylpropyl, 2-methylbutyl, 3-methylbutyl, n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1- dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl, n-heptyl, 2-methylhexyl, 3-methylhexyl, 4- methylhexyl, 5-methylhexyl, 2,3-dimethylpentyl, 2,4-dimethylpentyl, 2,2-dimethylpentyl, 3,3- dimethylpentyl, 2-ethylpentyl, 3-ethylpentyl, n-octyl, 2,3-dimethylhexyl, 2,4-dimethylhexyl, 2,5- dimethylhexyl, 2,2-dimethylhexyl, 3,3-dimethylhexyl, 4,4-dimethylhexyl, 2-ethylhexyl, 3-ethylhexyl, 4-ethylhexyl, 2-methyl-2-ethylpentyl, 2-methyl-3-ethylpentyl, n-nonyl, 2-methyl-2-ethylhexyl, 2- methyl-3-ethylhexyl, 2,2-diethylpentyl, n-decyl, 3,3-diethylhexyl, 2,2-diethylhexyl, and various branched isomers thereof. "Alkenyl" refers to linear or branched unsaturated aliphatic hydrocarbon groups having one or more carbon-carbon double bonds (C=C). "<com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenyl" refers to an alkenyl group having 2 to 10 carbon atoms, preferably C<com:Sub>2-8< / com:Sub> alkenyl, more preferably C<com:Sub>2-6< / com:Sub> alkenyl, further preferably C<com:Sub>2-4< / com:Sub> alkenyl, with a similar definition. Non-limiting examples of alkenyl include vinyl, propenyl, isopropenyl, n-butenyl, isobutenyl, pentenyl, hexenyl, and the like. "Alkynyl" refers to linear and branched unsaturated aliphatic hydrocarbon groups having one or more carbon-carbon triple bonds. "<com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynyl" refers to an alkynyl group having 2 to 10 carbon atoms, 25 preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynyl, more preferably <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkynyl, further preferably <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkynyl, with a similar definition. Non-limiting examples of alkynyl include ethynyl, propynyl, n-butynyl, isobutynyl, pentynyl, hexynyl, and the like. "Alkylene" is divalent and requires two binding partners. Formally, the second valence is generated by removing a hydrogen atom from an alkyl group, such as -CH3 and -CH2-, -CH2CH3 and -CH2CH2- or -CH(CH<com:Sub>3< / com:Sub>)-, and the like. In certain embodiments, <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkylene is preferred, more preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkylene, further preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkylene, most preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene. For example, <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkylene includes -CH<com:Sub>2< / com:Sub>-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>2< / com:Sub>-, -CH(CH<com:Sub>3< / com:Sub>)-, -(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-, -CH(CH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>)-, -CH<com:Sub>2< / com:Sub>CH(CH<com:Sub>3< / com:Sub>)- and -C(CH<com:Sub>3< / com:Sub>)<com:Sub>2< / com:Sub>-. In certain embodiments, alkylene can be methylene, ethylene, propylene, 1-methylethylene, butylene, 1- methylpropylene 1,1-dimethylethylene, 1,2-dimethylethylene, pentylene, 1,1-dimethylpropylene, 2,2- dimethylpropylene, 1,2-dimethylpropylene, 1,3-dimethylpropylene, and the like. In the absence of any further definition, the generic terms propylene, butylene, pentylene, hexylene, etc., refer to all conceivable isomeric forms having the corresponding number of carbon atoms, i.e., propylene includes 1-methylethylene, and butylene includes 1-methylpropylene, 2-methylpropylene, 1,1-dimethylethylene and 1,2-dimethylethylene. "Alkenylene" consists of at least two carbon atoms, wherein at least two adjacent carbon atoms are connected by a C-C double bond, and the carbon atoms can be part of only one C-C double bond. Formally, in the alkylene defined above, if two hydrogen atoms on adjacent carbon atoms are formally 5 removed and the free valences are saturated to form a second bond, the corresponding alkenylene is formed. In certain embodiments, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkenylene is preferred, more preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenylene, further preferably C<com:Sub>2-6< / com:Sub> alkenylene, most preferably C<com:Sub>2-4< / com:Sub> alkenylene. In certain embodiments, alkenylene can be ethenylene, propenylene, 1-methylethenylene, butenylene, 1-methylpropenylene, 1,1- dimethylethenylene, 1,2-dimethylethenylene, pentenylene, 1,1-dimethylpropenylene, <com:Math><semantics>2,2−<annotation encoding="application / x-tex">2,2-< / annotation>< / semantics>< / com:Math> dimethylpropenylene, 1,2-dimethylpropenylene, 1,3-dimethylpropenylene, hexenylene, and the like. In the absence of any further definition, the generic terms propenylene, butenylene, pentenylene, hexenylene, etc., refer to all conceivable isomeric forms having the corresponding number of carbon atoms, i.e., propenylene includes 1-methylpropenylene, and butenylene includes 1-methylpropenylene, 2-methylpropenylene, 1,1-dimethylethenylene and 1,2-dimethylethenylene. For one or more double bonds, alkenylene may optionally exist in cis or trans, or E or Z forms. "Alkynylene" consists of at least two carbon atoms, wherein at least two adjacent carbon atoms are connected by a C-C triple bond. Formally, in the alkylene defined above, if two hydrogen atoms are removed from two adjacent carbon atoms and the free valences are saturated to form two additional bonds, the corresponding alkynylene is formed. In certain embodiments, <com:Math><semantics>C2−10<annotation encoding="application / x-tex">C_{2-10}< / annotation>< / semantics>< / com:Math> alkynylene is preferred, more preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynylene, further preferably <com:Math><semantics>C2−6<annotation encoding="application / x-tex">C_{2-6}< / annotation>< / semantics>< / com:Math> alkynylene, most preferably <com:Math><semantics>C2−4<annotation encoding="application / x-tex">C_{2-4}< / annotation>< / semantics>< / com:Math> alkynylene. In certain embodiments, alkynylene can be ethynylene, propynylene, 1-methylethynylene, butynylene, 1- methylpropynylene, 1,1-dimethylethynylene, 1,2-dimethylethynylene, pentynylene, 1,1- dimethylpropynylene, 2,2-dimethylpropynylene, 1,2-dimethylpropynylene, 1,3-dimethylpropynylene, hexynylene, and the like. In the absence of any further definition, the generic terms propynylene, 25 butynylene, pentynylene, hexynylene, etc., refer to all conceivable isomeric forms having the corresponding number of carbon atoms, i.e., propynylene includes 1-methylethynylene, and butynylene includes 1-methylpropynylene, 2-methylpropynylene, 1,1-dimethylethynylene and 1,2- dimethylethynylene. "Alkyleneoxy" refers to a divalent alkoxy group. In certain embodiments, C<com:Sub>1-10< / com:Sub> alkyleneoxy is preferred, more preferably <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> alkyleneoxy, further preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyleneoxy, most preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyleneoxy. In certain embodiments, alkyleneoxy can be -OCH<com:Sub>2< / com:Sub>-, -OCH(CH<com:Sub>3< / com:Sub>)CH<com:Sub>2< / com:Sub>-, -OCH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O-, - CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>O-, and the like. In the absence of any further definition, the generic terms propyleneoxy, butyleneoxy, pentyleneoxy, hexyleneoxy, etc., refer to all conceivable isomeric forms having the corresponding number of carbon atoms, i.e., propyleneoxy includes -O(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>O-, -O(CH<com:Sub>2< / com:Sub>)<com:Sub>3< / com:Sub>-, - <com:Math><semantics>OCH2CH(CH3)<annotation encoding="application / x-tex">OCH_2CH(CH_3)< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(CH3)2<annotation encoding="application / x-tex">-OC(CH_3)_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OCH(CH3)CH2<annotation encoding="application / x-tex">-OCH(CH_3)CH_2< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OCH2CH(CH3)O<annotation encoding="application / x-tex">-OCH_2CH(CH_3)O< / annotation>< / semantics>< / com:Math>-, <com:Math><semantics>−OC(CH3)2O<annotation encoding="application / x-tex">-OC(CH_3)_2O< / annotation>< / semantics>< / com:Math>- and <com:Math><semantics>−<annotation encoding="application / x-tex">-< / annotation>< / semantics>< / com:Math> <com:Math><semantics>OCH(CH3)CH2O−.<annotation encoding="application / x-tex">OCH(CH_3)CH_2O-.< / annotation>< / semantics>< / com:Math> "Cycloalkyl" and "cycloalkyl ring" are used interchangeably and both refer to a monocyclic or polycyclic cyclic hydrocarbon group, which may be fused to an aryl or heteroaryl group. The cycloalkyl ring may be optionally substituted. In certain embodiments, the cycloalkyl ring includes one or more of spiro rings and bridged rings. In certain embodiments, the cycloalkyl ring contains one or more carbonyl groups, such as oxo groups. "C<com:Sub>3-15< / com:Sub> cycloalkyl" refers to a monocyclic or polycyclic cycloalkyl group having 3 to 15 carbon atoms, such as spiro[4.5]decane, spiro[3.3]heptane, spiro[5.5]undecane, dispiro[5.2.59.26]hexadecane, decahydroazulene, 1,2-diethylcyclopent-1-ene, bicyclo[3.3.2]decane. Preferred are C<com:Sub>3-8< / com:Sub> cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexyl, cyclooctyl, cyclobutanone, cyclopentanone, cyclopentane-1,3-dione, and the like. Preferred are C<com:Sub>3-7< / com:Sub> cycloalkyl, such as cycloheptane, spiro[3.3]heptane, etc., more preferably C<com:Sub>3-6< / com:Sub> cycloalkyl, including cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. It can be a saturated cycloalkyl, such as cyclohexyl, cyclopropyl, etc. It can be a partially unsaturated cycloalkyl, such as cyclohexene, 1,2-diethylcyclopent- 1-ene, etc. "Spiro ring" refers to a polycyclic group in which single rings share one carbon atom (called the spiro atom), which may contain one or more double bonds, but no ring has a fully conjugated <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math>- electron system. Spiro rings are classified as dispiro rings or polyspiro rings based on the number of rings, with dispiro rings being preferred. More preferred are 4-membered / 5-membered, 5-membered / 5- membered or 5-membered / 6-membered dispiro rings. For example: [Image disponible dans le document PDF, Image available in the PDF document] "Cycloalkylene" and "cycloalkylene ring" are used interchangeably, both are divalent and require two binding partners. Formally, the second valence is generated by removing a hydrogen atom from a cycloalkyl group, for example "Spiro-heterocycle" refers to a polycyclic hydrocarbon in which single rings share one atom (referred to as the spiro atom), wherein one or two ring atoms are heteroatoms selected from nitrogen, oxygen or S(O)n (wherein n is an integer from 0 to 2), and the remaining ring atoms are carbon, which may contain one or more double bonds, but no ring has a fully conjugated <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math>-electron system. Spiroheterocycles are classified as dispiroheterocycles or polyspiroheterocycles based on the number of rings, with dispiroheterocycles being preferred. More preferred are 4-membered / 5-membered, 5- membered / 5-membered or 5-membered / 6-membered dispiroheterocycles. For example: [Image disponible dans le document PDF, Image available in the PDF document] "Bridged ring" refers to a polycyclic group in which two or more carbon atoms are shared. The shared carbon atoms are referred to as bridgehead carbons, and between two bridgehead carbons there may be a carbon chain or a single bond, which is referred to as a bridge. These may contain one or more double bonds, but no ring has a fully conjugated <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math>-electron system. Preferred are bicyclic or tricyclic bridged rings. For example: [Image disponible dans le document PDF, Image available in the PDF document] "Bridged heterocycle" refers to a polycyclic group in which two or more atoms are shared, wherein one or more ring atoms are heteroatoms selected from nitrogen, oxygen or S(O)n (wherein n is an integer from 0 to 2), and the remaining ring atoms are carbon. These may contain one or more double bonds, but no ring has a fully conjugated <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math>-electron system. Preferred are bicyclic or tricyclic bridged heterocycles. For example: [Image disponible dans le document PDF, Image available in the PDF document] "Heterocycloalkyl" and "heterocycloalkyl ring" are used interchangeably, both refer to a cycloalkyl group containing at least one heteroatom selected from nitrogen, oxygen and sulfur, and the group may be fused to an aryl or heteroaryl group. The heterocycloalkyl ring may be a saturated heterocycloalkyl ring or a partially unsaturated heterocycloalkyl ring. The heterocycloalkyl ring may be optionally substituted. In certain embodiments, the heterocycloalkyl ring includes one or more of spiro- heterocycles and bridged heterocycles. In certain embodiments, the heterocycloalkyl ring contains one or more carbonyl or thiocarbonyl groups, such as groups containing oxo and thio. "3- to 15-membered heterocycloalkyl" refers to a heterocycloalkyl group having 3 to 15 ring atoms, wherein 1, 2 or 3 ring atoms are heteroatoms selected from nitrogen, oxygen and sulfur. Preferred are 3- to 10-membered heterocycloalkyl, more preferably 3- to 7-membered heterocycloalkyl, further more preferably 3- to 7- membered heterocycloalkyl, further preferably 3- to 6-membered heterocycloalkyl. Non-limiting examples of heterocycloalkyl include aziridinyl, oxiranyl, azetidinyl, oxetanyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyrrolyl, oxazolidinyl, dioxolanyl, piperidinyl, piperazinyl, morpholinyl, dioxanyl, thiomorpholinyl, thiomorpholine-1,1-dioxide, tetrahydropyranyl, azetidin-2-onyl, oxetan-2- onyl, dihydrofuran-2(3H)-onyl, pyrrolidin-2-onyl, pyrrolidine-2,5-dionyl, dihydrofuran-2,5-dionyl, piperidin-2-onyl, tetrahydro-2H-pyran-2-onyl, piperazin-2-onyl, morpholin-3-onyl, 2,3-dihydrofuran, 2,5-dihydrofuran, 2,5-dihydro-1H-pyrrole, 1,2,3,4-tetrahydropyridine, 1,2,3,6-tetrahydropyridine, and the like. 5 "Heterocycloalkylene" and "heterocycloalkylene ring" are used interchangeably, both are divalent and require two binding partners. Formally, the second valence is generated by removing a hydrogen atom from a cycloalkyl group, for example "Aryl" and "aryl ring" are used interchangeably, both refer to a group of a monocyclic, bicyclic or polycyclic 4n+2 aromatic ring system having ring carbon atoms (e.g., having 6 or 10, or 14 <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math> electrons shared in a cyclic arrangement). In the present application, the aryl ring may be optionally substituted. "<com:Math><semantics>C6−14<annotation encoding="application / x-tex">C_{6-14}< / annotation>< / semantics>< / com:Math> aryl" refers to an aryl group having 6 to 14 ring carbon atoms. "<com:Math><semantics>C6−10<annotation encoding="application / x-tex">C_{6-10}< / annotation>< / semantics>< / com:Math> aryl" refers to an aryl group having 6 to 10 ring carbon atoms. Non-limiting examples include phenyl, naphthyl and anthracenyl. "Arylene" and "arylene ring" are used interchangeably, both are divalent and require two binding partners. Formally, the second valence is generated by removing a hydrogen atom from a cycloalkyl [Image disponible dans le document PDF, Image available in the PDF document] group, for example "Heteroaryl" and "heteroaryl ring" are used interchangeably, both refer to a group of a monocyclic, bicyclic or polycyclic 4n+2 aromatic ring system having ring carbon atoms and ring heteroatoms (e.g., having 6 or 10 or 14 <com:Math><semantics>π<annotation encoding="application / x-tex">\pi< / annotation>< / semantics>< / com:Math> electrons shared in a cyclic arrangement), wherein each heteroatom is independently selected from nitrogen, oxygen and sulfur. In the present application, heteroaryl also includes ring systems in which the aforementioned heteroaryl ring is fused to one or more cycloalkyl rings, heterocycloalkyl rings, cycloalkenyl rings, heterocycloalkenyl rings or aryl rings. The heteroaryl ring may be optionally substituted. "5- to 15-membered heteroaryl" refers to a monocyclic heteroaryl having 5 to 15 ring atoms, wherein 1, 2, 3 or 4 ring atoms are heteroatoms. "5- to 6-membered heteroaryl" refers to a monocyclic heteroaryl having 5 to 6 ring atoms, wherein 1, 2, 3 or 4 ring atoms are 25 heteroatoms. Non-limiting examples include thienyl, furyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, pyrrolyl, pyrazolyl, triazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, tetrazolyl, isoxazolyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, tetrazinyl, quinolinyl, isoquinolinyl, benzopyrrolyl, benzofuranyl, benzothienyl, benzopyrazolyl, benzimidazolyl, benzotriazolyl, benzotetrazolyl, benzoxazolyl, benzisoxazolyl, benzoxadiazolyl, benzothiazolyl, benzothiadiazolyl, pyridopyrrolyl, pyridofuranyl, pyridothienyl, pyridopyrazolyl, pyridoimidazolyl, pyridotriazolyl, pyridotetrazolyl, pyridooxazolyl, pyridoisoxazolyl, pyridooxadiazolyl, pyridothiazolyl, pyridothiadiazolyl, pyrimidopyrrolyl, pyrimidofuranyl, pyrimidothienyl, pyrimidopyrazolyl, pyrimidoimidazolyl, pyrimidotriazolyl, pyrimidotetrazolyl, pyrimidooxazolyl, pyrimidoisoxazolyl, pyrimidooxadiazolyl, pyrimidothiazolyl, pyrimidothiadiazolyl, pyridazopyrrolyl, pyridazofuranyl, pyridazothienyl, pyridazopyrazolyl, pyridazoimidazolyl, pyridazotriazolyl, pyridazotetrazolyl, pyridazooxazolyl, pyridazoisoxazolyl, pyridazooxadiazolyl, pyridazothiazolyl, pyridazothiadiazolyl, pyrazinopyrrolyl, pyrazinofuranyl, pyrazinothienyl, pyrazinopyrazolyl, pyrazinoimidazolyl, pyrazinotriazolyl, pyrazinotetrazolyl, pyrazinooxazolyl, pyrazinoisoxazolyl, pyrazinooxadiazolyl, pyrazinothiazolyl, pyrazinothiadiazolyl, triazinopyrrolyl, triazinofuranyl, triazinothienyl, triazinopyrazolyl, triazinoimidazolyl, triazinotriazolyl, triazinotetrazolyl, triazinooxazolyl, triazinoisoxazolyl, triazinooxadiazolyl, triazinothiazolyl, triazinothiadiazolyl, benzoquinolinyl, benzoisoquinolinyl and carbazolyl. "Heteroatom" refers to nitrogen, oxygen or sulfur. In a heteroaryl containing one or more nitrogen atoms, the point of attachment may be a carbon or nitrogen atom, provided that the valence allows. A heteroaryl bicyclic system may include one or more heteroatoms in one or two rings. "Heteroarylene" and "heteroarylene ring" are used interchangeably, both are divalent and require two binding partners. Formally, the second valence is generated by removing a hydrogen atom from a [Image disponible dans le document PDF, Image available in the PDF document] cycloalkyl group, for example "Halogen" refers to fluorine (F), chlorine (Cl), bromine (Br) or iodine (I). "Halo" refers to the substitution of one or more (e.g., 1, 2, 3 or all) hydrogen atoms in a group with halogen. "Haloalkyl" refers to an alkyl group substituted with one or more (e.g., 1, 2, 3 or all) halogen atoms, wherein alkyl is as defined above. Preferred are <com:Math><semantics>C1−8<annotation encoding="application / x-tex">C_{1-8}< / annotation>< / semantics>< / com:Math> haloalkyl, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> haloalkyl, even more preferably C<com:Sub>1-3< / com:Sub> haloalkyl. Examples of haloalkyl include, but are not limited to, chloromethyl, dichloromethyl, trichloromethyl, chloroethyl, 1,2-dichloroethyl, trichloroethyl, bromoethyl, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, and the like. "Alkoxy" refers to -O-alkyl, wherein alkyl is as defined above. Preferred are C<com:Sub>1-8< / com:Sub> alkoxy, more preferably <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy, most preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy. Non-limiting examples of alkoxy include methoxy, ethoxy, n-propoxy, isopropoxy, butoxy, tert-butoxy, isobutoxy, pentyloxy, and the like. "Alkoxyalkyl" refers to an alkyl group substituted with one or more alkoxy groups, wherein alkyl and alkoxy are as defined above. Preferred are <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkoxy <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkoxy <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl. Non-limiting examples of alkoxyalkyl include -CH<com:Sub>2< / com:Sub>OCH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>OCH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub>, -CH<com:Sub>2< / com:Sub>CH<com:Sub>2< / com:Sub>OCH<com:Sub>3< / com:Sub>, and the like. "Cycloalkylalkyl" refers to an alkyl group substituted with one or more cycloalkyl groups, wherein alkyl and cycloalkyl are as defined above. Preferred are <com:Math><semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>< / com:Math> cycloalkyl <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C3−6<annotation encoding="application / x-tex">C_{3-6}< / annotation>< / semantics>< / com:Math> cycloalkyl C<com:Sub>1-3< / com:Sub> alkyl. Non-limiting examples of cycloalkylalkyl include -CH<com:Sub>2< / com:Sub>-cyclopropyl, -CH<com:Sub>2< / com:Sub>- cyclobutyl, -CH<com:Sub>2< / com:Sub>-cyclobutyl, and the like. "Alkenylalkyl" refers to an alkyl group substituted with one or more alkenyl groups, wherein alkyl and alkenyl are as defined above. Preferred are <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenyl <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenyl <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> 8 alkyl, further preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenyl <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, further preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkenyl <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl. Non-limiting examples of cycloalkylalkyl include <com:Math><semantics>−H2C−HC=CH2<annotation encoding="application / x-tex">-H_2C-HC=CH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2CH2−HC=CH2<annotation encoding="application / x-tex">-CH_2CH_2-HC=CH_2< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2CH2−HC=CH2<annotation encoding="application / x-tex">-CH_2CH_2-HC=CH_2< / annotation>< / semantics>< / com:Math>, and the like. "Alkynylalkyl" refers to an alkyl group substituted with one or more alkynyl groups, wherein alkyl and alkynyl are as defined above. Preferred are <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynyl <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> alkyl, more preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynyl <com:Math><semantics>C1−10<annotation encoding="application / x-tex">C_{1-10}< / annotation>< / semantics>< / com:Math> 8 alkyl, further preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynyl <com:Math><semantics>C1−6<annotation encoding="application / x-tex">C_{1-6}< / annotation>< / semantics>< / com:Math> alkyl, further preferably <com:Math><semantics>C2−8<annotation encoding="application / x-tex">C_{2-8}< / annotation>< / semantics>< / com:Math> alkynyl <com:Math><semantics>C1−3<annotation encoding="application / x-tex">C_{1-3}< / annotation>< / semantics>< / com:Math> alkyl. Non-limiting −ÇH<com:Sub>2< / com:Sub>CH<com:Sub>3< / com:Sub> examples of cycloalkylalkyl include, <com:Math><semantics>−H2C−C≡CH<annotation encoding="application / x-tex">-H_2C-C \equiv CH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>−CH2CH2−C≡CH<annotation encoding="application / x-tex">-CH_2CH_2-C \equiv CH< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>c≡CH<annotation encoding="application / x-tex">c \equiv CH< / annotation>< / semantics>< / com:Math>, and the like. "Heterocycloalkylalkyl" refers to an alkyl group substituted with one or more heterocycloalkyl groups, wherein alkyl and heterocycloalkyl are as defined above. Preferred are 4- to 10-membered heterocycloalkyl C<com:Sub>1-6< / com:Sub> alkyl, more preferably 4- to 8-membered heterocycloalkyl C<com:Sub>1-3< / com:Sub> alkyl, further preferably 3- to 6-membered heterocycloalkyl <...

Claims

1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein, POI is a ligand that binds to an EED protein; L is a linker connecting POI and ULM; ULM is a group that binds to an E3 ligase; and n0 is 0 or 1.

2. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein POI is a structure of formula (A-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] ( A − 1 ) (A-1) wherein, ring A1 is a 5- to 20-membered heterocycloalkyl ring or a 5- to 10-membered heteroaryl ring; ring A2 is absent, or is a 3- to 15-membered heterocycloalkyl ring, a C 3 − 10 C_{3-10} cycloalkyl ring, a 5- to 15- membered heteroaryl ring or a C 6 − 10 C_{6-10} aryl ring; ( R 1 ) n 1 (R_1)_{n_1} represents substitution of hydrogen on 2,3-dihydrobenzofuran ring by n 1 n_1 R 1 R_1 , n 1 n_1 is 0, 1 or 2, each R 1 is identical or different, and each R 1 is independently selected from the group consisting of hydrogen, deuterium, halogen, oxo, C 1 − 8 C_{1-8} alkyl, C 1 − 8 C_{1-8} haloalkyl, C 1 − 8 C_{1-8} alkoxy, C 1 − 8 C_{1-8} haloalkoxy, -COC 1-8 alkyl, − O C O C 1 − 8 -OCOC_{1-8} alkyl, − C O O C 1 − 8 -COOC_{1-8} alkyl, − C O N H 2 -CONH_{2} , − C O N H C 1 − 8 -CONHC_{1-8} alkyl, − C O N ( C 1 − 8 -CON(C_{1-8} alkyl) 2 , − S O C 1 − 8 -SOC_{1-8} alkyl, − S O 2 C 1 − 8 -SO_{2}C_{1-8} alkyl, − O S O 2 C 1 − 8 -OSO_2C_{1-8} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 8 -SO_2NHC_{1-8} alkyl, − S O 2 N ( C 1 − 8 -SO_2N(C_{1-8} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 12- membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl; and / or two R 1 R_1 and carbon atom linked to the two R 1 R_1 together form a C 3 − 15 C_{3-15} cycloalkyl ring or a 3- to 15-membered heterocycloalkyl ring; the C 1 − 8 C_{1-8} alkyl, C 1 − 8 C_{1-8} haloalkyl, C 1 − 8 C_{1-8} alkoxy, C 1 − 8 C_{1-8} haloalkoxy, − C O C 1 − 8 -COC_{1-8} alkyl, − C O O C 1 − 8 -COOC_{1-8} alkyl, − C O O C 1 − 8 -COOC_{1-8} alkyl, -CONH 2 , -CONHC 1-8 alkyl, -CON( C 1 − 8 C_{1-8} alkyl) 2 , -SOC 1-8 alkyl, -SO 2 C 1-8 alkyl, -OSO 2 C 1-8 alkyl, -SO 2 NH 2 , − S O 2 N H C 1 − 8 -SO_2NHC_{1-8} alkyl, − S O 2 N ( C 1 − 8 -SO_2N(C_{1-8} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10- membered heteroaryl, C 6-14 aryl, C 3-15 cycloalkyl ring and 3- to 15-membered heterocycloalkyl ring are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkoxy, - C O C 1 − 6 COC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 -SO_2NHC_{1-6} alkyl, − S O 2 N ( C 1 − 6 -SO_2N(C_{1-6} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 12-membered heterocycloalkyl and 5- to 10-membered heteroaryl; ( R 2 ) n 2 (R_2)_{n2} represents substitution of hydrogen on ring A1 by n2 R 2 , n2 is 0, 1 or 2, each R 2 is identical or different, and each R 2 is independently selected from the group consisting of X 1 , hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, C 1 − 8 C_{1-8} alkyl, C 1 − 8 C_{1-8} haloalkyl, C 1 − 8 C_{1-8} alkoxy, C 1 − 8 C_{1-8} haloalkoxy, - NHC 1-8 alkyl, -N(C 1-8 alkyl) 2 , -COC 1-8 alkyl, -OCOC 1-8 alkyl, -COOC 1-8 alkyl, -CONH 2 , -CONHC 1-8 alkyl, − C O N ( C 1 − 8 alkyl ) 2 -CON(C_{1-8} \text{ alkyl})_2 , − P O ( C 1 − 8 alkyl ) 2 -PO(C_{1-8} \text{ alkyl})_2 , − S O C 1 − 8 alkyl -SOC_{1-8} \text{ alkyl} , − S O 2 C 1 − 8 alkyl -SO_2C_{1-8} \text{ alkyl} , − O S O 2 C 1 − 8 alkyl -OSO_2C_{1-8} \text{ alkyl} , − S C 1 − 6 alkyl -SC_{1-6} \text{ alkyl} , − S C 1 − 6 alkyl -SC_{1-6} \text{ alkyl} , − S C 1 − 6 alkyl -SC_{1-6} \text{ alkyl} , − S C 1 − 6 -SC_{1-6} SO 2 NH 2 , -SO 2 NHC 1-8 alkyl, -SO 2 N(C 1-8 alkyl) 2 , C 3-8 cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl; the C 1 − 8 C_{1-8} alkyl, C 1 − 8 C_{1-8} haloalkyl, C 1 − 8 C_{1-8} alkoxy, C 1 − 8 C_{1-8} haloalkoxy, - NHC 1-8 alkyl, -N(C 1-8 alkyl) 2 , -COC 1-8 alkyl, -OCOC 1-8 alkyl, -COOC 1-8 alkyl, -CONH 2 , -CONHC 1-8 alkyl, − C O N ( C 1 − 8 alkyl ) 2 -CON(C_{1-8} \text{ alkyl})_2 , − P O ( C 1 − 8 alkyl ) 2 -PO(C_{1-8} \text{ alkyl})_2 , − S O C 1 − 8 alkyl -SOC_{1-8} \text{ alkyl} , − S O 2 C 1 − 8 alkyl -SO_2C_{1-8} \text{ alkyl} , − O S O 2 C 1 − 8 alkyl -OSO_2C_{1-8} \text{ alkyl} , − S O 2 N H 2 -SO_2NH_2 , − - SO 2 NHC 1-8 alkyl, -SO 2 N(C 1-8 alkyl) 2 , C 3-8 cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10- membered heteroaryl and C 6 − 14 C_{6-14} aryl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, NHC 1-6 alkyl, -N(C 1-6 alkyl) 2 , -COC 1-6 alkyl, -OCOC 1-6 alkyl, - C O O C 1 − 6 COOC_{1-6} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − P O ( C 1 − 6 -PO(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 -SO_2NHC_{1-6} alkyl, − S O 2 N ( C 1 − 6 -SO_2N(C_{1-6} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 12- membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl; or R 1 , R 2 and carbon atom linked to R 1 and R 2 together form a 6- to 15-membered heterocycloalkyl ring; the 6- to 15-membered heterocycloalkyl ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of halogen, cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkoxy, -NHC 1-6 alkyl, -N( C 1 − 6 C_{1-6} alkyl) 2 , -COC 1-6 alkyl, - O C O C 1 − 6 OCOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − P O ( C 1 − 6 -PO(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 -SO_2NHC_{1-6} alkyl, − S O 2 N ( C 1 − 6 -SO_2N(C_{1-6} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl; ( R 3 ) n 3 (R_3)_{n3} represents substitution of hydrogen on ring A2 by n3 R 3 , n3 is 0, 1, 2 or 3, each R 3 is identical or different, and each R 3 is independently selected from the group consisting of X 1 , hydrogen, deuterium, cyano, carboxyl, nitro, formyl, sulfo, halogen, oxo, C 1 − 10 C_{1-10} alkyl, C 1 − 10 C_{1-10} haloalkyl, C 1 − 10 C_{1-10} alkoxy, C 1 − 10 C_{1-10} haloalkoxy, − C O C 1 − 10 -COC_{1-10} alkyl, − O C O C 1 − 10 -OCOC_{1-10} alkyl, − C O O C 1 − 10 -COOC_{1-10} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 10 -CONHC_{1-10} alkyl, − C O N ( C 1 − 10 ) -CON(C_{1-10}) a l k y l ) 2 alkyl)_2 , − S O C 1 − 10 -SOC_{1-10} a l k y l alkyl , − S O 2 C 1 − 10 -SO_2C_{1-10} a l k y l alkyl , − O S O 2 C 1 − 10 -OSO_2C_{1-10} a l k y l alkyl , − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 10 -SO_2NHC_{1-10} a l k y l alkyl , − S O 2 N ( C 1 − 10 ) -SO_2N(C_{1-10}) alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 15-membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl; the C 1 − 10 C_{1-10} alkyl, C 1 − 10 C_{1-10} haloalkyl, C 1 − 10 C_{1-10} alkoxy, C 1 − 10 C_{1-10} haloalkoxy, − C O C 1 − 10 -COC_{1-10} alkyl, − O C O C 1 − 10 -OCOC_{1-10} alkyl, − C O O C 1 − 10 -COOC_{1-10} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 10 -CONHC_{1-10} alkyl, − C O N ( C 1 − 10 -CON(C_{1-10} alkyl) 2 , − S O C 1 − 10 -SOC_{1-10} alkyl, − S O 2 C 1 − 10 -SO_2C_{1-10} alkyl, − O S O 2 C 1 − 10 -OSO_2C_{1-10} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 10 -SO_2NHC_{1-10} alkyl, − S O 2 N ( C 1 − 10 -SO_2N(C_{1-10} alkyl) 2 , C 3 − 8 C_{3-8} cycloalkyl, 3- to 15-membered heterocycloalkyl, 5- to 10-membered heteroaryl and C 6 − 14 C_{6-14} aryl are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, C 1-6 alkyl, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkoxy, − C O C 1 − 6 -COC_{1-6} alkyl, − O C O C 1 − 6 -OCOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} C O N H C 1 − 6 CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 3 , − S O C 1 − 6 -SOC_{1-6} SO 2 NHC 1-6 alkyl, -SO 2 N(C 1-6 alkyl) 2 , C 3-6 cycloalkyl, 3- to 15-membered heterocycloalkyl, 5- to 10- membered heteroaryl, phenyl and naphthyl; X 1 X_1 in R 2 R_2 and R 3 R_3 is a point of attachment of POI to L or ULM, and at least one of R 2 R_2 and R 3 R_3 is X 1 X_1 .

3. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein ring A1 is an 8- to 10-membered heteroaryl ring, a 5- to 6-membered heterocycloalkyl ring or an 18-membered heterocycloalkyl ring; or, ring A1 is a 9-membered heteroaryl ring or a 10-membered heteroaryl ring; or, ring A1 is a 9-membered nitrogen-containing heteroaryl ring or a 10-membered nitrogen- containing heteroaryl ring; or, ring A1 is selected from the group consisting of an indolizine ring, a pyrazolopyridine ring, an imidazopyridine ring, a triazolopyridine ring, a tetrazolopyridine ring, a pyrrolopyridazine ring, a pyrazolopyridazine ring, an imidazopyridazine ring, a triazolopyridazine ring, a tetrazolopyridazine ring, a pyrrolopyrimidine ring, a pyrazolopyrimidine ring, an imidazopyrimidine ring, a triazolopyrimidine ring, a tetrazolopyrimidine ring, a pyrrolopyrazine ring, a pyrazolopyrazine ring, an imidazopyrazine ring, a triazolopyrazine ring, a pyridopyridine ring, a pyridopyrazine ring, a pyridopyridazine ring, a pyridotriazine ring, a pyridopyrimidine ring and a tetrazolopyrazine ring; or, ring A1 is selected from the group consisting of [1,2,4]triazolo[4,3-c]pyrimidine, imidazo[1,5- c]pyrimidine, imidazo[1,2-c]pyrimidine, [1,2,4]triazolo[4,3-a]pyridine and pyrido[3,4-d]pyridazine; or, ring A1 is selected from the group consisting of pyrimidin-4(3H)-one, 1,6-dihydropyrimidine, pyridin-2(1H)-one, 1,2-dihydropyridine and 3,8-diazabicyclo[3.2.1]octane; or, ring A1 is a partially unsaturated 18-membered heterocycloalkyl ring; or, ring A1 is selected from the group consisting of 2,3-dihydro-7'H-spiro[indene-1,8'-pyrido[3,4- d]pyridazin]-7'-one and 2,3-dihydro-7'H-spiro[indene-1,8'-pyrido[4,3-c]pyridazin]-7'-one; and / or, wherein A 1 A1 is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] is selected from the group consisting of the following structures or isomers thereof: or. [Image disponible dans le document PDF, Image available in the PDF document] is selected from the group consisting of the following structures or isomers thereof: or, and HN is selected from the group consisting of the following structures or isomers thereof: or, [Image disponible dans le document PDF, Image available in the PDF document]4. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein POI is a structure of formula (A-2-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] ( A − 2 − 1 ) (A-2-1) wherein, W 1 , W 2 , W 3 , W 4 , W 5 and W 6 are each independently CH or N, ring A2, R 1 , n1, R 2 , n2, R 3 , and n3 are as defined in claim 2, and at least one of R 2 R_2 and R 3 R_3 is X 1 X_1 ; or, POI is a structure of formula (A-2-2) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] (M-Z-Z) wherein, W 1 , W 2 , W 3 , W 4 and W 5 are each independently CH or N; ring A2, R 1 , n1, R 2 , n2, R 3 and n3 are as defined in claim 2, and at least one of R 2 R_2 and R 3 R_3 is X 1 X_1 ; and / or, wherein POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] , wherein, ring A2, R 1 , n1, R 2 , n2, R 3 and n3 are as defined in claim 2, and at least one of R 2 and R 3 is X 1 X_1 .

5. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein ring A2 is absent or is selected from the group consisting of a 4- to 8- membered heterocycloalkyl ring, a C 4-8 cycloalkyl ring, a 5- to 10-membered heteroaryl ring, a 10- to 15- membered heterocycloalkyl ring and a benzene ring; or, ring A2 is absent or is selected from the group consisting of a 4- to 8-membered heterocycloalkyl ring, a saturated C 4-8 cycloalkyl ring, a 5- to 10-membered heteroaryl ring, a partially unsaturated 10- to 15-membered heterocycloalkyl ring and a benzene ring; or, ring A2 is absent, or is selected from the group consisting of a cyclobutane ring, a cyclopentane ring, a cyclohexane ring, an azetidine ring, a tetrahydropyrrole ring, a pyrazolidine ring, an imidazolidine ring, a piperidine ring, a hexahydropyridazine ring, a hexahydropyrimidine ring, a piperazine ring, a benzene ring, a pyrazole ring, an oxazole ring, an imidazole ring, a triazole ring, a tetrazole ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, an indolizine ring, pyrazolopyridine, imidazopyridine, triazolopyridine, tetrazolopyridine, pyrrolopyridazine, pyrazolopyridazine, imidazopyridazine, triazolopyridazine, tetrazolopyridazine, pyrrolopyrimidine, pyrazolopyrimidine, imidazopyrimidine, triazolopyrimidine, tetrazolopyrimidine, pyrrolopyrazine, pyrazolopyrazine, imidazopyrazine, triazolopyrazine, tetrazolopyrazine, pyridopyridine, pyridopyrazine, pyridopyridazine, pyridotriazine, pyridopyrimidine, 3,8-diazabicyclo[3.2.1]octane and 2,3-dihydrospiro[indene-1,4'- piperidine]; or, ring A2 is absent or is selected from the group consisting of a saturated 6-membered heterocycloalkyl ring, a partially unsaturated 12-membered heterocycloalkyl ring, a cyclohexane ring, a 5- to 6-membered heteroaryl ring, a 9-membered heteroaryl ring and a benzene ring; or, ring A2 is absent or is selected from the group consisting of a cyclohexane ring, a piperidine ring, a piperazine ring, a benzene ring, a pyridine ring, a pyrazole ring, a triazolopyridine ring and 2,3- dihydrospiro[indene-1,4'-piperidine]; or, ring A2 is selected from the group consisting of a benzene ring, a pyridine ring and a pyrazole ring; is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] is selected from the group consisting of the following structures: NH-N N=N NH N and or, 1S or. is selected from the group consisting of the following structures or isomers thereof: and or. is selected from the group consisting of the following structures or isomers thereof: and6. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein R 1 is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, isopropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, methoxy, ethoxy, propoxy, isopropoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, pyrrolyl, pyrazolyl, pyridinyl, phenyl, pyrimidinyl, -CH 2 -cyclopropyl, -CH 2 -tetrahydropyrrolyl, -CH 2 -pyrrolyl, -CH 2 -phenyl, - CH 2 -pyridinyl, -CH 2 -cyclohexenyl, -CH 2 -azetidine, -CH 2 -piperidine, -CH 2 -piperazine, tetrahydro-2H- pyran and -CH 2 -(tetrahydro-2H-pyran); or two R 1 and carbon atom linked to the two R 1 together form a cyclopropyl ring, a cyclobutyl ring, a cyclopentyl ring, a cyclobutene ring, a cyclopentene ring, a cyclohexene ring, an azetidine ring, a tetrahydropyrrole ring, a piperidine ring or a piperazine ring; or, R 1 is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, iodine, -CH 3 , -CH 2 CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH 2 F, -CHF 2 , -CF 3 , -OCH 3 , -OCH 2 CH 3 , - OCH 2 CH 2 CH 3 , -OCH(CH 3 ) 2 , -OCH 2 F, -OCH 5 , -OCF 3 , -CH 2 CH 2 F, -CH 2 CHF 2 , -CH 2 CF 3 , -OCH 2 CH 2 F, - OCH 2 CHF 2 and -OCH 2 CF 3 ; or, two R 1 R_1 and carbon atom linked to the two R 1 R_1 together form a cyclopropyl ring; or, R 1 R_1 is fluorine; [Image disponible dans le document PDF, Image available in the PDF document] ; or,7. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein R 2 R_2 is selected from the group consisting of X 1 X_1 , hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHC 1-6 alkyl, -N(C 1-6 alkyl) 2 , -CONH 2 , -CONHC 1-6 alkyl, − C O N ( C 1 − 6 alkyl ) 2 -CON(C_{1-6} \text{ alkyl})_2 , − C O C 1 − 6 alkyl -COC_{1-6} \text{ alkyl} , − C O O C 1 − 6 alkyl -COOC_{1-6} \text{ alkyl} , − O C O C 1 − 6 alkyl -OCOC_{1-6} \text{ alkyl} , − P O ( C 1 − 6 alkyl ) 2 -PO(C_{1-6} \text{ alkyl})_2 , − S O C 1 − 6 alkyl -SOC_{1-6} \text{ alkyl} , − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S C 1 − 6 -SC_{1-6} alkyl, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl and C 1 − 6 C_{1-6} haloalkoxy; or, R 2 R_2 is selected from the group consisting of X 1 X_1 , hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHC 1-6 alkyl, -N(C 1-6 alkyl) 2 , -CONH 2 , -CONHC 1-6 alkyl, -CON(C 1-6 alkyl) 2 , - COC 1-3 alkyl, -COOC 1-3 alkyl, -OCOC 1-3 alkyl, -PO(C 1-3 alkyl) 2 , -SOC 1-3 alkyl, -SO 2 C 1-3 alkyl, -OSO 2 C 1-3 alkyl, − S C 1 − 3 -SC_{1-3} alkyl, C 1 − 3 C_{1-3} alkyl, C 1 − 3 C_{1-3} alkoxy, C 1 − 3 C_{1-3} haloalkyl and C 1 − 3 C_{1-3} haloalkoxy; or, R 2 is selected from the group consisting of X 1 , hydrogen, deuterium, halogen, cyano, carboxyl, hydroxyl, amino, oxo, -NHCH 3 , -N(CH 3 ) 2 , -CONH 2 , -CONHCH 3 , -CON(CH 3 ) 2 , -COCH 3 , -COC(CH 3 ) 3 , - COOCH 3 , -COOCH 2 CH 3 , -COOC(CH 3 ) 3 , -OCOCH 3 , -OCOCH 2 CH 3 , -OCOC(CH 3 ) 3 , -PO(CH 3 ) 2 , - PO(CH 2 CH 3 ) 2 , -SOCH 3 , -SOCH 2 CH 3 , -SOC(CH 3 ) 3 , -SO 2 CH 3 , -SO 2 CH 2 CH 3 , -SO 2 C(CH 3 ) 3 , -OSO 2 CH 3 , - OSO 2 CH 2 CH 3 , -OSO 2 C(CH 3 ) 3 , -SCH 3 , -SCH 2 CH 3 , methyl, ethyl, propyl, isopropyl, tert-butyl, methoxy, ethoxy, propoxy, isopropoxy, tert-butoxy, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, monofluoropropyl, difluoropropyl, trifluoropropyl, monofluoroisopropyl, difluoroisopropyl, trifluoroisopropyl, monofluoro-tert-butyl, difluoro-tert-butyl, trifluoro-tert-butyl, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, monofluoropropoxy, difluoropropoxy, trifluoropropoxy, monofluoroisopropoxy, difluoroisopropoxy, trifluoroisopropoxy, monofluoro-tert-butoxy, difluoro-tert- butoxy and trifluoro-tert-butoxy; or, R 2 is selected from the group consisting of cyano, fluorine, chlorine, bromine, iodine, -CH 3 , -CF 3 , -SO 2 CH 3 and hydrogen; or, R 2 is selected from the group consisting of cyano, fluorine, chlorine, bromine, iodine, -SO 2 CH 3 and hydrogen; or, R 2 is selected from the group consisting of X 1 , hydrogen, halogen, cyano, -SO 2 C 1-6 alkyl and - O S O 2 C 1 − 6 OSO_2C_{1-6} alkyl; or, R 2 is selected from the group consisting of X 1 , hydrogen, halogen, cyano, -SO 2 C 1-3 alkyl and - O S O 2 C 1 − 3 OSO_2C_{1-3} alkyl; or, R 2 is selected from the group consisting of X 1 , hydrogen, fluorine, chlorine, bromine, iodine, cyano, -SO 2 CH 3 and -OSO 2 CH 3 ; [Image disponible dans le document PDF, Image available in the PDF document] and / or, wherein is selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document]8. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein R 3 R_3 is selected from the group consisting of X 1 X_1 , halogen, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 3-8 cycloalkyl, -COC 1-6 alkyl, -OCOC 1-6 alkyl, -COOC 1-6 alkyl, - C O N H 2 CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − - SO 2 NHC 1-6 alkyl, -SO 2 N(C 1-6 alkyl) 2 , 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl; the C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, C 3 − 8 C_{3-8} cycloalkyl, -COC 1-6 alkyl, - O C O C 1 − 6 OCOC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − C O N H 2 -CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 -SO_2NHC_{1-6} alkyl, − S O 2 N ( C 1 − 6 -SO_2N(C_{1-6} alkyl) 2 , 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, -COC 1-3 alkyl, -COOC 1-3 alkyl, -CONH 2 , - C O N H C 1 − 3 CONHC_{1-3} alkyl, − C O N ( C 1 − 3 -CON(C_{1-3} alkyl) 2 , − S O C 1 − 3 -SOC_{1-3} alkyl, − S O 2 C 1 − 3 -SO_2C_{1-3} alkyl, − O S O 2 C 1 − 3 -OSO_2C_{1-3} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H 2 -SO_2NH_2 SO 2 NHC 1-3 alkyl, -SO 2 N(C 1-3 alkyl) 2 , C 3-6 cycloalkyl, 4- to 6-membered heterocycloalkyl, 5- to 6- membered heteroaryl and phenyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , halogen, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, C 3-8 cycloalkyl, -COC 1-6 alkyl, -OCOC 1-6 alkyl, -COOC 1-6 alkyl, -CONH 2 , -CONHC 1-6 alkyl, - C O N ( C 1 − 6 alkyl ) 2 CON(C_{1-6} \text{ alkyl})_2 , − S O C 1 − 6 alkyl -SOC_{1-6} \text{ alkyl} , − S O 2 C 1 − 6 alkyl -SO_2C_{1-6} \text{ alkyl} , − O S O 2 C 1 − 6 alkyl -OSO_2C_{1-6} \text{ alkyl} , − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 alkyl -SO_2NHC_{1-6} \text{ alkyl} , − S O 2 N ( C 1 − 6 alkyl ) 2 -SO_2N(C_{1-6} \text{ alkyl})_2 6 alkyl) 2 , 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl; the C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 3-8 cycloalkyl, -COC 1-6 alkyl, -OCOC 1-6 alkyl, -COOC 1-6 alkyl, - C O N H 2 CONH_2 , − C O N H C 1 − 6 -CONHC_{1-6} alkyl, − C O N ( C 1 − 6 -CON(C_{1-6} alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, − O S O 2 C 1 − 6 -OSO_2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − - SO 2 NHC 1-6 alkyl, -SO 2 N(C 1-6 alkyl) 2 , 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl are unsubstituted or substituted with 1, 2, or 3 substituents selected from the group consisting of cyano, hydroxyl, carboxyl, nitro, formyl, sulfo, halogen, methyl, trifluoromethyl, methoxy, trifluoromethoxy, -COCH 3 , -OCOCH 3 , -COOCH 3 , -CONH 2 , -CONHCH 3 , -CON(CH 3 ) 2 , -SOCH 3 , - SO 2 CH 3 , -SO 2 NH 2 , -SO 2 NHCH 3 , -SO 2 N(CH 3 ) 2 , cyclopropyl, cyclobutyl, cyclopentyl, cyclopexyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, azetidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl and phenyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , halogen, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, C 3-8 cycloalkyl, -COC 1-6 alkyl, -OCOC 1-6 alkyl, -COOC 1-6 alkyl, -CONH 2 , -CONHC 1-6 alkyl, - C O N ( C 1 − 6 alkyl ) 2 CON(C_{1-6} \text{ alkyl})_2 , − S O C 1 − 6 alkyl -SOC_{1-6} \text{ alkyl} , − S O 2 C 1 − 6 alkyl -SO_2C_{1-6} \text{ alkyl} , − O S O 2 C 1 − 6 alkyl -OSO_2C_{1-6} \text{ alkyl} , − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 alkyl -SO_2NHC_{1-6} \text{ alkyl} , − S O 2 N ( C 1 − 6 alkyl ) 2 -SO_2N(C_{1-6} \text{ alkyl})_2 6 alkyl) 2 , 4- to 8-membered heterocycloalkyl, 5- to 6-membered heteroaryl and phenyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, tert-butyl, methoxy, ethoxy, isopropoxy, tert-butoxy, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, monofluoroethoxy, difluoroethoxy, trifluoroethoxy, -COCH3, - COCH 2 CH 3 , -COC(CH 3 ) 3 , -OCOCH 3 , -OCOCH 2 CH 3 , -OCOC(CH 3 ) 3 , -COOCH 3 , -COOCH 2 CH 3 , - COOC(CH 3 ) 3 , -CONH 2 , -CONHCH 3 , -CON(CH 3 ) 2 , -SOCH 3 , -SO 2 CH 3 , -SO 2 C(CH 3 ) 3 , -OSO 2 CH 3 , - OSO 2 C(CH 3 ) 3 , -SO 2 NH 2 , -SO 2 NHCH 3 , -SO 2 N(CH 3 ) 2 , cyclopropyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, azetidinyl, piperazinyl, piperidinyl, 1,2,3,6-tetrahydropyridinyl, pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrimidinyl and phenyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , C 1 − 6 C_{1-6} alkyl, C 3 − 8 C_{3-8} cycloalkyl, C 1 − 6 C_{1-6} haloalkyl and - C O C 1 − 6 COC_{1-6} alkyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , C 1 − 3 C_{1-3} alkyl, C 3 − 6 C_{3-6} cycloalkyl, C 1 − 3 C_{1-3} haloalkyl and - C O C 1 − 3 COC_{1-3} alkyl; or, R 3 R_3 is selected from the group consisting of X 1 X_1 , methyl, cyclopropyl, trifluoromethyl and -COCH 3 ; or, R 3 is selected from the group consisting of X 1 , fluorine and methyl; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] ; X 1 X_1 is the point of attachment to L or ULM.

9. The compound of formula (I) according to claim 2, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] 1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] I [Image disponible dans le document PDF, Image available in the PDF document] wherein X 1 X_1 is the point of attachment to L or ULM; or, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] and o ; wherein X 1 X_1 is the point of attachment to L or ULM; or, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein X 1 X_1 is the point of attachment to L or ULM; IN or, POI is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein X 1 X_1 is the point of attachment to L or ULM. UIV10. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein L is a structure of formula (L-1) or an isomer thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein m1 is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; each L a at each occurrence is independently selected from the group consisting of a chemical bond, - C ( O ) C(O) -, − C ( O ) N R L 1 -C(O)NR_{L1} -, − N R L 1 -NR_{L1} -, − O -O -, − S -S -, C 1 − 10 C_{1-10} alkylene, C 1 − 10 C_{1-10} alkyleneoxy, C 2 − 10 C_{2-10} alkenylene, C 2 − 10 C_{2-10} alkynylene, a C 3-15 cycloalkylene ring, a 3- to 15-membered heterocycloalkylene ring, a 5- to 15-membered heteroarylene ring and a C 6 − 14 C_{6-14} arylene ring; the C 1 − 10 C_{1-10} alkylene, C 1 − 10 C_{1-10} alkyleneoxy, C 2 − 10 C_{2-10} alkenylene, C 2 − 10 C_{2-10} alkynylene, C 3-15 cycloalkylene ring, 3- to 15-membered heterocycloalkylene ring, 5- to 15-membered heteroarylene ring and C 6-14 arylene ring are unsubstituted or substituted with 1, 2, 3 or 4 R L2 , each R L2 is independently selected from the group consisting of deuterium, halogen, hydroxyl, cyano, amino, carboxyl, formyl, oxo, sulfo, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, hydroxy-substituted C 1 − 6 C_{1-6} alkyl, cyano-substituted C 1 − 6 C_{1-6} alkyl, amino-substituted C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkyl, C 3 − 6 C_{3-6} cycloalkyl, C 3-6 cycloalkyl C 1-6 alkyl, 3- to 6-membered heterocycloalkyl, 3- to 6-membered heterocycloalkyl C 1 − 6 C_{1-6} alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl C 1 − 6 C_{1-6} alkyl, phenyl, phenyl C 1-6 alkyl, -COC 1-6 alkyl, -COOC 1-6 alkyl, -OCOC 1-6 alkyl, -CONH 2 , -CONHC 1-6 alkyl, -CON(C 1-6 alkyl) 2 , − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO2C_{1-6} alkyl, − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C 1 − 6 -SO_2NHC_{1-6} alkyl and − S O 2 N ( C 1 − 6 -SO_2N(C_{1-6} alkyl) 2 ; each R L1 at each occurrence is independently selected from the group consisting of hydrogen, deuterium, C 1 − 8 C_{1-8} alkyl, C 1 − 8 C_{1-8} haloalkoxy and C 1 − 8 C_{1-8} haloalkyl.

11. The compound of formula (I) according to claim 10, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein each R L1 at each occurrence is independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tert-butyl, methoxy, ethoxy, isopropoxy, tert- butoxy, trifluoromethyl, difluoromethyl, monofluoromethyl, trifluoroethyl, difluoroethyl, monofluoroethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoroethoxy, difluoroethoxy and monofluoroethoxy; or, each R L1 at each occurrence is independently selected from the group consisting of hydrogen, methyl, ethyl, difluoromethyl and monofluoromethyl; or, R L1 is hydrogen; and / or, wherein each R L2 is independently selected from the group consisting of deuterium, halogen, hydroxyl, cyano, amino, carboxyl, hydroxymethyl, hydroxyethyl, methyl, ethyl, difluoromethyl, monofluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, cyclopentenyl, tetrahydropyrrolyl, tetrahydrofuranyl, phenyl, pyrrolyl, furanyl, thiazolyl, oxazolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, -CH 2 -cyclopropyl, -CH 2 -cyclobutyl, -CH 2 -cyclopentyl, - CH 2 -cyclohexyl, -CH 2 -cyclohexenyl, -CH 2 -cyclopentenyl, -CH 2 -tetrahydropyrrolyl, -CH 2 - tetrahydrofuranyl, -CH 2 -phenyl, -CH 2 -pyrrolyl, -CH 2 -triazolyl, -CH 2 -tetrazolyl, -CH 2 -pyridyl, -CH 2 - pyrazinyl, -CH 2 -triazinyl, methoxy, ethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethoxy, acetyl, acetamido and sulfonamido; or, each R L2 is independently selected from the group consisting of deuterium, -F, -Cl, -Br, -OH, -CN, -CHO, -COOH, -NH 2 , -CH 2 OH, -CH 2 CH 2 OH, -CH 3 , -CH 2 CH 3 , -CH 2 F, -CH 5 , -CH 5 , -CH 2 CH 2 F, - CH 2 CHF 2 , -CH 2 CF 3 , -OCH 3 , -OCH 2 CH 3 , -OCH 2 F 1 , -OCH 2 F 2 , -OCH 3 , -OCH 2 CH 2 F 2 , -OCH 2 CHF 2 , -OCH 3 OCH 2 CF 3 , -COCH 3 , -CH 2 -cyclopropyl, cyclopropyl, -CONH 2 , -COOCH 3 , -OCOCH 3 , -CONHCH 3 , - C O N ( C H 3 ) 2 CON(CH_3)_2 , − S O C H 3 -SOCH_3 , − S O 2 C H 3 -SO_2CH_3 , − S O 2 N H 2 -SO_2NH_2 , − S O 2 N H C H 3 -SO_2NHCH_3 and − S O 2 N ( C H 3 ) 2 -SO_2N(CH_3)_2 ; or, each R L2 is independently selected from the group consisting of deuterium, -F, -Cl, -Br, -OH, -CN, -COOH, -NH 2 , -CH 2 OH, -CH 2 CH 2 OH, -CH 3 , -CH 2 CH 3 , -CH 2 F, -CH 5 , -CF 3 , -CH 2 CH 2 F, -CH 2 CHF 2 , - CH 2 CF 3 , -OCH 3 , -OCH 2 CH 3 , -OCH 2 F, -OCH 5 , -OCH 2 CH 5 , -OCH 2 CH 5 , -OCH 2 CH 5 , -OCH 2 CH 3 , -OCH 3 , -CH 2 -cyclopropyl, cyclopropyl and -CONH 2 ; or, each R L2 is independently selected from the group consisting of fluorine, chlorine, bromine, hydroxyl and hydroxymethyl; and / or, wherein each L a is independently selected from the group consisting of the following structures or isomers thereof: − C ( O ) -C(O) -, − C ( O ) N H -C(O)NH -, − O -O -, − S -S -, − N H -NH -, C 1 − 10 C_{1-10} alkylene, C 1 − 10 C_{1-10} alkyleneoxy, a C 3 − 12 C_{3-12} cycloalkylene ring, a 4- to 12-membered heterocycloalkylene ring, a 5- to 6-membered heteroarylene ring and a phenylene ring; the C 3 − 12 C_{3-12} cycloalkylene ring, 4- to 12-membered heterocycloalkylene ring, 5- to 6- membered heteroarylene ring and phenylene ring are unsubstituted or substituted with 1, 2, 3 or 4 R L2 , and R L 2 R_{L2} is selected from the group consisting of fluorine, hydroxyl and hydroxymethyl; or, each L a is independently selected from the group consisting of the following structures or isomers thereof: -O-, -S-, -NH-, -C(O)-, -C(O)NH-, -(CH 2 ) m2 -, -O(CH 2 ) m2 -, -(CH 2 ) m2 O-, and a divalent form of a cyclic group selected from the group consisting of: a cyclopropane ring, a cyclobutane ring, a bicyclopentane ring, a cyclopentane ring, a cyclohexane ring, an azetidine ring, a tetrahydropyrrole ring, a piperidine ring, a piperazine ring, a hydroxy-substituted piperidine ring, a hydroxy-substituted piperazine ring, a hydroxymethyl-substituted piperidine ring, a hydroxymethyl-substituted piperazine ring, 3,3,5,5- tetramethylpiperidine, 3,3-difluoropiperidine, a 2-azaspiro[3.3]heptane ring, a 6-azaspiro[3.4]octane ring, a 7-azaspiro[3.5]nonane ring, a 2,6-diazaspiro[3.3]heptane ring, a 2,6-diazaspiro[3.4]octane ring, a 2,7- diazaspiro[3.5]nonane ring, a 2-azaspiro[3.5]nonane ring, a spiro[3.3]heptane ring, a spiro[3.4]octane ring, a spiro[3.5]nonane ring, 3,9-diazaspiro[5.5]undecane, a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a triazine ring, a thiophene ring, a furan ring, a pyrrole ring, a thiazole ring, an oxazole ring, a pyrazole ring, an imidazole ring and a triazole ring; wherein each m2 at each occurrence is independently 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; or, each L a is independently selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] or, each La is independently selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document]12. The compound of formula (I) according to claim 10, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein L is selected from the group consisting of the following structures or isomers thereof: − ( C H 2 ) m 3 -(CH_2)_{m3} -, − C ( O ) − ( C H 2 ) m 3 -C(O)-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N H − ( C H 2 ) m 3 -C(O)NH-(CH_2)_{m3} -, − C ( O ) N -C(O)N C y 0 Cy_0 -, − N H − C y 0 -NH-Cy_0 -, − C y 0 − N H − ( C H 2 ) m 3 -Cy_0-NH-(CH_2)_{m3} -, − C y 0 − ( C H 2 ) m 3 − N H -Cy_0-(CH_2)_{m3}-NH -, − C y 0 − ( C H 2 ) m 3 − O -Cy_0-(CH_2)_{m3}-O -, − C ( O ) N H − C y 0 -C(O)NH-Cy_0 -, − ( C H 2 ) m 3 -(CH_2)_{m3} - C ( O ) N H − ( C H 2 ) m 3 − O − C y 0 − O − ( C H 2 ) m 3 − C(O)NH-(CH_2)_{m3}-O-Cy_0-O-(CH_2)_{m3}- , − C y 0 − C y 0 − -Cy_0-Cy_0- , − ( C H 2 ) m 3 − C y 0 − O − ( C H 2 ) m 3 − -(CH_2)_{m3}-Cy_0-O-(CH_2)_{m3}- , − C y 0 − C ( O ) N H − C y 0 − -Cy_0-C(O)NH-Cy_0- , − ( C H 2 ) m 3 − -(CH_2)_{m3}- C y 0 − ( C H 2 ) m 3 − C y 0 − Cy_0-(CH_2)_{m3}-Cy_0- , − C y 0 − O − C y 0 − -Cy_0-O-Cy_0- , − C y 0 − C ( O ) − C y 0 − -Cy_0-C(O)-Cy_0- , − ( C H 2 ) m 3 − C y 0 − C y 0 -(CH_2)_{m3}-Cy_0-Cy_0 and − C ( O ) N H − ( C H 2 ) m 3 − C y 0 − ( C H 2 ) m 3 − -C(O)NH-(CH_2)_{m3}-Cy_0-(CH_2)_{m3}- Cy 0 ; wherein each m3 at each occurrence is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; each Cy 0 at each occurrence is independently selected from the group consisting of a C 3 − 12 C_{3-12} cycloalkyl ring, a 3- to 12- membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring and a benzene ring; the C 3-12 cycloalkyl ring, 3- to 12-membered heterocycloalkyl ring, 5- to 6-membered heteroaryl ring, benzene ring are unsubstituted or substituted with 1, 2, 3 or 4 R L2 , each R L2 at each occurrence is independently selected from the group consisting of deuterium, halogen, hydroxyl, cyano, amino, carboxyl, C 1 − 3 C_{1-3} alkyl, C 1 − 3 C_{1-3} alkoxy, C 1 − 3 C_{1-3} haloalkyl, C 1 − 3 C_{1-3} haloalkoxy, hydroxy-substituted C 1 − 3 C_{1-3} alkyl, cyano-substituted C 1 − 3 C_{1-3} alkyl, amino-substituted C 1 − 3 C_{1-3} alkyl, C 1 − 3 C_{1-3} alkoxy C 1 − 3 C_{1-3} alkyl, C 3 − 6 C_{3-6} cycloalkyl, C 3 − 6 C_{3-6} cycloalkyl C 1 − 3 C_{1-3} alkyl, -COC 1-3 alkyl, -COOC 1-3 alkyl, -OCOC 1-3 alkyl, -CONH 2 , -CONHC 1-3 alkyl and -CON(C 1-3 alkyl) 2 ; or, each Cy 0 is independently selected from the group consisting of a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, a bicyclopentane ring, a cyclohexane ring, an azetidine ring, a hydroxy-substituted azetidine ring, a tetrahydropyrrole ring, a piperidine ring, a hydroxy-substituted piperidine ring, a hydroxymethyl-substituted piperidine ring, a 4-fluoropiperidine ring, 3,3- difluoropiperidine, 3,3,5,5-tetramethylpiperidine, a piperazine ring, a 2-azaspiro[3.3]heptane ring, a 6- azaspiro[3.4]octane ring, a 7-azaspiro[3.5]nonane ring, a 2,6-diazaspiro[3.3]heptane ring, a 2,6- diazaspiro[3.4]octane ring, a 2,7-diazaspiro[3.5]nonane ring, a 2-azaspiro[3.5]nonane ring, a spiro[3.3]heptane ring, a spiro[3.4]octane ring, a spiro[3.5]nonane ring, 3,9-diazaspiro[5.5]undecane, a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a triazine ring, a thiophene ring, a furan ring, a pyrrole ring, a thiazole ring, an oxazole ring, a pyrazole ring, an imidazole ring and a triazole ring; or, each Cy 0 is independently selected from the group consisting of a cyclobutane ring, a bicyclopentane ring, a benzene ring, an azetidine ring, a piperidine ring, a piperazine ring and 3,9- diazaspiro[5.5]undecane; or, each Cy 0 is independently selected from the group consisting of a cyclobutane ring, an azetidine ring, a benzene ring and a piperidine ring; or, each Cy 0 is independently selected from the group consisting of the following structures or [Image disponible dans le document PDF, Image available in the PDF document] or, each Cy 0 is independently selected from the group consisting of the following structures or isomers thereof: N, N, N, and and ...

13. The compound of formula (I) according to claim 10, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein L is selected from the group consisting of the following [Image disponible dans le document PDF, Image available in the PDF document] attachment of L to ULM or POI; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] point of attachment of L to ULM or POI; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein X 10 X_{10} is the point of attachment of L to POI, and X 20 X_{20} is the point of attachment of L to ULM; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ; the point of attachment of L to POI, and X 20 X_{20} is the point of attachment of L to ULM; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ; wherein X 10 X_{10} is the point of attachment of L to POI, and X 20 is the point of attachment of L to ULM; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] wherein X 10 X_{10} is the point of attachment of L to POI, and X 20 X_{20} is the point of attachment of L to ULM; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ⋁ \bigvee ''\ ⋁ \bigvee and 0 ; wherein X 10 X_{10} is the point of attachment of L to POI, and X 20 X_{20} is the point of attachment of L to ULM; or, L is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ; wherein X 10 X_{10} is the point of attachment of L to POI, and X 20 X_{20} is the point of attachment of L to ULM.

14. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein ULM is a compound of formula (U-1) or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] ( U − 1 ) (U-1) wherein, ===== represents ==== (double bond) or ——— (single bond); U 0 U_0 is a chemical bond, − N ( R U 0 ) -N(R_{U0}) -, − C O N ( R U 0 ) -CON(R_{U0}) -, − C H 2 -CH_2 - or − ( C H 2 ) 2 -(CH_2)_2 -; each R U0 at each occurrence is independently hydrogen or C 1-3 alkyl; ring B is absent or is selected from the group consisting of a 5- to 15-membered heteroaryl ring, a 3- to 15-membered heterocycloalkyl ring, a C 3 − 15 C_{3-15} cycloalkyl ring and a C 6 − 10 C_{6-10} aryl ring; S 1 , S 3 and S 5 are each independently selected from the group consisting of a chemical bond, -O-, - NH-, -N-, -CH 2 -, -CH-, -C(O)-, -C(O)O-, -C(O)S-, -CH 2 C(O)-, -CH 2 C(S)-, -C(S)-, -CONH-, -CH=N-, - N = N − N=N- , -CH=CH-, -SO- and -SO 2 -; S 2 and S 4 are each independently selected from the group consisting of -N-, -NH-, -CH- and -CH 2 -; S 6 is selected from the group consisting of C, -CH- and N; (R B1 ) b1 represents substitution of hydrogen on ring B by b1 R B1 , b1 is 0, 1, 2 or 3, each R B1 is identical or different, and each R B1 is independently selected from the group consisting of X 2 , deuterium, halogen, cyano, carboxyl, hydroxyl, nitro, -NR a1 R b1 , C 1-8 alkyl, C 1-8 alkoxy, -SOC 1-8 alkyl, -SO 2 C 1-8 alkyl, C 1 − 8 C_{1-8} haloalkyl, C 1 − 8 C_{1-8} haloalkoxy, amino-substituted C 1 − 8 C_{1-8} alkyl, cyano-substituted C 1 − 8 C_{1-8} alkyl, hydroxy- substituted C 1-8 alkyl, carboxy-substituted C 1-8 alkyl, -COC 1-8 alkyl, -COOC 1-8 alkyl-CONR a2 R b2 , - SO 2 NR a2 R b2 , a C 3-15 cycloalkyl ring, a 3- to 15-membered heterocycloalkyl ring, a 5- to 10-membered heteroaryl ring and a C 6-10 aryl ring; or two adjacent R B1 and carbon atom linked to the two adjacent R B1 together form a C 3-15 cycloalkyl ring, a 3- to 15-membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring or a benzene ring; the C 3 − 15 C_{3-15} cycloalkyl ring, 3- to 15-membered heterocycloalkyl ring, 5- to 6-membered heteroaryl ring or benzene ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: X 2 , deuterium, halogen, cyano, carboxyl, hydroxyl, nitro, -NR a1 R b1 , C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, − S C 1 − 6 -SC_{1-6} alkyl, − S O C 1 − 6 -SOC_{1-6} alkyl, − S O 2 C 1 − 6 -SO_2C_{1-6} alkyl, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, − C O C 1 − 6 -COC_{1-6} alkyl, -COOC 1-6 alkyl, -CONR a2 R b2 and -SO 2 NR a2 R b2 ; (R B2 ) b2 represents substitution of hydrogen on ring C by b2 R B2 , b2 is 0, 1, 2, 3 or 4, each R B2 is identical or different, and each R B2 is independently selected from the group consisting of X 2 , deuterium, halogen, cyano, carboxyl, hydroxyl, -NRa1 R b 1 R_{b1} , C 1 − 6 C_{1-6} alkyl, C 1 − 6 C_{1-6} alkoxy, C 1 − 6 C_{1-6} haloalkyl, C 1 − 6 C_{1-6} haloalkoxy, - C O C 1 − 6 COC_{1-6} alkyl, − C O O C 1 − 6 -COOC_{1-6} alkyl, − O C O C 1 − 6 -OCOC_{1-6} alkyl, − C O N R a 2 R b 2 -CONR_{a2}R_{b2} , − O C ( O ) C 1 − 6 -OC(O)C_{1-6} alkyl-substituted C 1 − 6 C_{1-6} alkyl and − - C O O C 1 − 6 COOC_{1-6} alkyl-substituted C 1 − 6 C_{1-6} alkyl; R a1 , R b1 , R a2 and R b2 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1 − 6 C_{1-6} haloalkyl, hydroxy-substituted C 1 − 6 C_{1-6} alkyl, cyano-substituted C 1 − 6 C_{1-6} alkyl, carboxy-substituted C 1 − 6 C_{1-6} alkyl, amino-substituted C 1 − 6 C_{1-6} alkyl, − C O C 1 − 6 -COC_{1-6} alkyl and − C O O C 1 − 6 -COOC_{1-6} alkyl; X 2 in R B1 and R B2 is a point of attachment of ULM to L or POI, and at least one of R B1 and R B2 is X 2 .

15. The compound of formula (I) according to claim 14, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein R B 1 R_{B1} and R B 2 R_{B2} are not both X 2 X_2 ; and / or, wherein ring B is absent; or the 5- to 15-membered heteroaryl ring in ring B is selected from the group consisting of a pyrrole ring, a furan ring, a thiophene ring, a pyrazole ring, an imidazole ring, a triazole ring, a tetrazole ring, an oxazole ring, a thiazole ring, an oxadiazole ring, a thiadiazole ring, a pyridine ring, a pyridazine ring, a pyrimidine ring, a pyrazine ring, a triazine ring, a benzopyrrole ring, a benzofuran ring, a benzothiophene ring, a benzopyrazole ring, a benzimidazole ring, a benzothiazole ring, a benzoxazole ring, a pyridopyrrole ring, a pyridofuran ring, a pyridothiophene ring, a pyridopyrazole ring, a pyridoimidazole ring, a pyridothiazole ring, a pyridooxazole ring, a pyrimidopyrrole ring, a pyridazopyrrole ring, a pyrazinopyrrole ring, a pyrimidopyrazole ring, a pyridazopyrazole ring, a pyrazinopyrazole ring, a pyrimidoimidazole ring, a pyridazoimidazole ring, a pyrazinoimidazole ring, a quinoline ring, an isoquinoline ring and a 9H-pyrido[2,3-b]indole ring; or, the 5- to 15-membered heteroaryl ring in ring B is a benzopyrazole ring; [Image disponible dans le document PDF, Image available in the PDF document] or the 3- to 15-membered heterocycloalkyl ring in ring B is , wherein Q 1 Q_1 , Q 2 Q_2 , Q 3 Q_3 , Q 4 Q_4 are each independently selected from the group consisting of -CH-, N and N-O; S 7 and S 8 are each independently selected from the group consisting of a chemical bond, -O-, -NH-, - CH 2 -, -C(O)-, -C(O)O-, -C(O)S-, -CH 2 C(O)-, -CH 2 C(S)-, -C(S)-, -CONH-, -CH=N-, -N=N-, -CH=CH-, - S O − SO- and − S O 2 − -SO_2- ; ∼ \sim represents a covalent connection to U 0 U_0 ; or, Q 1 Q_1 , Q 2 Q_2 , Q 3 Q_3 and Q 4 Q_4 are each independently -CH-; or, S 7 and S 8 are each independently selected from the group consisting of -CH 2 - and -C(O)-; or, S 7 S_7 is -CH 2 -, and S 8 S_8 is -C(O)-; or, S 7 S_7 is -C(O)-, and S 8 S_8 is -C(O)-; [Image disponible dans le document PDF, Image available in the PDF document] or, is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] ∼ \sim thereof: ; wherein ~~~ represents a covalent connection to U 0 U_0 ; [Image disponible dans le document PDF, Image available in the PDF document] or the 3- to 15-membered heterocycloalkyl ring in ring B is wherein ring B1 and ring B2 are each independently selected from the group consisting of a C 4-8 cycloalkyl ring, a 4- to 8- membered heterocycloalkyl ring, a 5- to 6-membered heteroaryl ring and a benzene ring; S 9 and S 10 are each independently selected from the group consisting of a bond, − C H 2 -CH_2 - and − C ( O ) -C(O) -; ∼ ∼ \sim\sim represents a covalent connection to U 0 U_0 ; [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] is selected from the group consisting of [Image disponible dans le document PDF, Image available in the PDF document] , ; wherein ∼ ∼ \sim \sim represents a covalent connection to U 0 U_0 ; [Image disponible dans le document PDF, Image available in the PDF document] or the 3- to 15-membered heterocycloalkyl ring in ring B is ; wherein ring B3 is a 3- to 7-membered heterocycloalkyl ring, and ∼ ∼ \sim\sim represents the covalent connection to U 0 ; or, ring B3 is a 5- to 7-membered nitrogen-containing heterocycloalkyl ring; or, ring B3 is a partially unsaturated 5- to 7-membered nitrogen-containing heterocycloalkyl ring; or, ring B3 is selected from the group consisting of 2,5-dihydro-1H-pyrrole, 2,3-dihydro-1H-pyrrole, 1,2,3,6-tetrahydropyridine, 1,2,3,4-tetrahydropyridine, 2,3,6,7-tetrahydro-1H-azepine, 2,3,4,7-tetrahydro- 1H-azepine and 2,3,4,5-tetrahydro-1H-azepine; [Image disponible dans le document PDF, Image available in the PDF document] represents the covalent connection to U 0 U_0 ; and / or, wherein ring B is selected from the group consisting of: a benzene ring. [Image disponible dans le document PDF, Image available in the PDF document] ; wherein ∼ \sim represents a covalent connection to U 0 U_0 ; [Image disponible dans le document PDF, Image available in the PDF document] or, ring B is selected from the group consisting of: wherein ∼ \sim represents a covalent connection to U 0 U_0 ; [Image disponible dans le document PDF, Image available in the PDF document] or, ring B is selected from the group consisting of: ; wherein ∼ \sim represents the covalent connection to U 0 U_0 ; and / or, wherein each R B1 is independently X 2 , deuterium, fluorine, chlorine, bromine, cyano, carboxyl, hydroxyl, nitro, -NH 2 , -N(CH 3 ) 2 , -NHCH 3 , -NHCOCH 3 , methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, trifluoromethyl, difluoromethyl, monofluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, -SCH 3 , -SOCH 3 , -SO 2 CH 3 , -CH 2 NH 2 , -(CH 2 ) 2 NH 2 , -(CH 2 ) 3 NH 2 , - C H 2 C N CH_2CN , − ( C H 2 ) 2 C N -(CH_2)_2CN , − ( C H 2 ) 3 C N -(CH_2)_3CN , − C H 2 O H -CH_2OH , − ( C H 2 ) 2 O H -(CH_2)_2OH , − ( C H 2 ) 3 O H -(CH_2)_3OH , − C H 2 C O O H -CH_2COOH , − ( C H 2 ) 2 C O O H -(CH_2)_2COOH , − ( C H 2 ) 3 C N -(CH_2)_3CN (CH 2 ) 3 COOH, -COCH 3 , -COCH 2 CH 3 , -COOCH 3 , -COOCH 2 CH 3 , -CONH 2 or -SO 2 NH 2 ; or two adjacent R B1 and carbon atom linked to the two adjacent R B1 together form a cyclobutyl ring, a cyclopentyl ring, a cyclohexyl ring, a cycloheptyl ring, a cyclopentene ring, a cyclohexene ring, a cycloheptene ring, a tetrahydropyrrole ring, a tetrahydrofuran ring, a tetrahydrothiophene ring, a piperidine ring, a pyrazine ring, a 1,2,3,4-tetrahydropyridine ring, a 1,2,3,4-tetrahydropyran ring, a 3,4-dihydro-2H-1,4-oxazine ring, a 2,3,4,5-tetrahydro-1H-azepine ring, a pyrrole ring, a pyrazole ring, an oxazole ring, a thiazole ring, a pyran ring, a pyridine ring, a pyridazine ring, a pyrimidine ring or a benzene ring; the cyclobutyl ring, cyclopentyl ring, cyclohexyl ring, cycloheptyl ring, cyclopentene ring, cyclohexene ring, cycloheptene ring, tetrahydropyrrole ring, tetrahydrofuran ring, tetrahydrothiophene ring, piperidine ring, pyrazine ring, 1,2,3,4-tetrahydropyridine ring, 1,2,3,4-tetrahydropyran ring, 3,4-dihydro-2H-1,4-oxazine ring, 2,3,4,5- tetrahydro-1H-azepine ring, pyrrole ring, pyrazole ring, oxazole ring, thiazole ring, pyran ring, pyridine ring, pyridazine ring, pyrimidine ring, or benzene ring is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: X 2 , deuterium, fluorine, chlorine, bromine, cyano, carboxyl, hydroxyl, nitro, amino, methyl, trifluoromethyl, methoxy, trifluoromethoxy, -SCH 3 , -SOCH 3 , - SO 2 CH 3 , -COCH 3 , -COOCH 3 , -CONH 2 and -SO 2 NH 2 ; or, R B1 is selected from the group consisting of X 2 , fluorine, chlorine, hydroxyl, methyl, trifluoromethyl and methoxy; [Image disponible dans le document PDF, Image available in the PDF document] _ and soss. represents a covarent connection to 60, [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] or, is selected from the group consisting of: wherein X 2 X_2 is the point of attachment of ULM to L or POI, and ∼ ∼ \sim \sim represents the covalent connection to U 0 U_0 ; and / or, wherein U 0 is a chemical bond, -NH-, -CONH- or -CH 2 -; and / or, wherein S 1 S_1 and S 3 S_3 are -C(O)-, S 2 S_2 is -NH-, S 4 S_4 and S 5 S_5 are -CH 2 -; and / or, wherein S 6 is CH or N; [Image disponible dans le document PDF, Image available in the PDF document] and / or, wherein is selected from the group consisting of the following structure [Image disponible dans le document PDF, Image available in the PDF document] or an isomer thereof: ( R B 2 ) b 2 (R_{B2})_{b2} ; wherein ∼ ∼ \sim\sim represents a covalent connection to U 0 U_0 ; S 1 − S 2 S_1 - S_2 -S 4 (R B2 ) b2 is selected from the group consisting of the following structures or isomers or, [Image disponible dans le document PDF, Image available in the PDF document] -NH thereof: and ; wherein ∼ ∼ \sim \sim represents a covalent connection to U 0 U_0 ; and / or, wherein ULM is selected from the group consisting of the following structures or isomers [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] www.iiiiiviiv or o.e.ivi vo e. or i org or, ULM is selected from the group consisting of the following structure or an isomer thereof: [Image disponible dans le document PDF, Image available in the PDF document] ; wherein X 2 X_2 is the point of attachment of ULM to L or POI; or, ULM is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] X 2 X_2 ΉM X 2 X_2 and ; wherein X 2 X_2 is the point of attachment of ULM to L or POI.

16. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein the compound of formula (I) is a structure of formula (I-A), [Image disponible dans le document PDF, Image available in the PDF document] (I-A) wherein ring A1, ring A2, R1, n1, R2, n2, R3 and n3 are as defined in claim 2, L, n0 and ULM are as defined in claim 1, and both R 2 R_2 and R 3 R_3 are not X 1 X_1 ; and / or, wherein the compound of formula (I) is a structure of formula (I-B), [Image disponible dans le document PDF, Image available in the PDF document] (I-B) wherein ring A1, ring A2, R1, n1, R2, n2, R3 and n3 are as defined in claim 2, L, n0 and ULM are as defined in claim 1, and both R 2 R_2 and R 3 R_3 are not X 1 X_1 ; and / or, wherein the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] ^ , 314 [Image disponible dans le document PDF, Image available in the PDF document] wherein ring A2, R1, n1, R2, n2, R3 and n3 are as defined in claim 2, L, n0 and ULM are as defined in claim 1, and both R 2 R_2 and R 3 R_3 are not X 1 X_1 ; and / or, wherein the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] 1 [Image disponible dans le document PDF, Image available in the PDF document] or is [Image disponible dans le document PDF, Image available in the PDF document] or, the compound of formula (I) is selected from the group consisting of the following structures or isomers thereof: [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] .) n0 -ULM HN-17. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein the compound of formula (I) is a compound selected from the group consisting of Table A or a stereoisomer thereof; and / or, wherein the compound of formula (I) is a compound selected from the group consisting of Table B or a stereoisomer thereof.

18. A pharmaceutical composition, comprising the compound of formula (I) according to any one of claims 1 to 17, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof; and a pharmaceutically acceptable carrier.

19. Use of the compound of formula (I) according to any one of claims 1 to 17, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or the pharmaceutical composition according to claim 18, in the manufacture of a medicament for preventing and / or treating an EED-mediated disease.

20. Use of the compound of formula (I) according to any one of claims 1 to 17, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or the pharmaceutical composition according to claim 18 for preventing and / or treating an EED-mediated disease.