Crystal form of acid salt of sulfoximine compound, preparation method therefor, and use thereof

Abstract

The present invention relates to a crystal form of a sulfoximine compound, a preparation method therefor, and a use thereof. Specifically, disclosed are a crystal form of a compound as shown in a formula (I), a preparation method therefor, and a use thereof. The crystal form has excellent stability, and can be widely applied to the preparation of drugs for preventing and / or treating diseases related to increased FGFR2 activity and expression level. The crystal form is preferably a hydrochloride crystal form I of the compound represented by formula I, and the X-ray powder diffraction pattern of the hydrochloride crystal form I has a 2θ angle selected from the following group: 6.68 + / -0.2 degrees, 13.34 + / -0.2 degrees, and 21.42 + / -0.2 degrees.

Description

CRYSTAL FORM OF ACID SALT OF SULFOXIMINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Technical Field The present invention relates to the field of medicinal development, specifically to a crystal form of an acid salt of a sulfoximine compound, preparation method therefor, and a use thereof. Background Fibroblast growth factor receptors (FGFRs) are receptors for fibroblast growth factor (FGF) signaling, and its family consists of four members (FGFR1, FGFR2, FGFR3, and FGFR4). Each FGFR is a glycoprotein composed of an extracellular immunoglobulin (Ig)-like domain, a hydrophobic transmembrane region, and an intracellular domain that includes a tyrosine kinase domain. Binding of FGF ligands induces receptor dimerization and conformational changes in the intracellular domain, leading to intermolecular phosphorylation in the kinase domain and the intracellular tail. Phosphorylated residues serve as docking sites for adaptor proteins, which facilitate downstream signaling cascades, resulting in cellular behaviors including proliferation, survival, differentiation, migration, and angiogenesis. Abnormal FGFR signaling is implicated in various cancer types, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma, bladder cancer, endometrial cancer, breast cancer, and lung cancer, and contributes to disease progression through overexpression, point mutations, and / or chromosomal translocations. As research progresses, pan-FGFR1-3 inhibitors have demonstrated clinical responses in various FGFR-altered cancers, however, they also exhibit target-limited toxicities, leading to adverse side effects such as hyperphosphatemia and tissue mineralization, as the regulation of phosphate reabsorption is mediated by FGFR1 and FGFR3. Some studies have reported FGFR2 translocations in 14% of intrahepatic cholangiocarcinomas; FGFR2 mutations occur in 12–14% of endometrial cancers and 5% of squamous non-small cell lung cancers; FGFR2 is amplified in 12–14% of gastric cancers and 4% of breast cancers. FGFR2 contributes to the development of acquired resistance to human epidermal growth factor receptor 2 (HER2)- targeted therapy by indirectly overactivating FGFR2 in tumor-associated fibroblasts. Therefore, given the unmet clinical needs, the development of FGFR2-selective inhibitors for treatment holds significant value and promising prospects. Summary of the Invention The objective of the present invention is to develop pharmaceutically acceptable salt forms and crystal forms of a sulfoximine FGFR inhibitor compound, and a preparation method therefor. In one aspect of the present invention, provided is a compound of formula (I), [Image disponible dans le document PDF, Image available in the PDF document] (I) in an amorphous form or a crystal form or a solvate thereof; wherein m is 1, 2, 3, 4, 5, 6, 7, 8, or 9; n is 0, 0.5, 1, 1.5, 2, 2.5, or 3; and X is selected from the group consisting of: hydrochloric acid, hydrobromic acid, hydrofluoric acid, sulfuric acid, nitric acid or phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, benzoic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, benzenesulfonic acid, naphthalenesulfonic acid, hippuric acid, glycolic acid, or glutaric acid. In another preferred embodiment, the structure of the compound of Formula I-1 is as follows: [Image disponible dans le document PDF, Image available in the PDF document] the present invention provides a crystal form A of the compound of Formula I-1, the X- ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.00±0.2∘<annotation encoding="application / x-tex">12.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.16±0.2∘<annotation encoding="application / x-tex">14.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.50±0.2∘<annotation encoding="application / x-tex">15.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.74±0.2∘<annotation encoding="application / x-tex">16.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.38±0.2∘<annotation encoding="application / x-tex">18.38\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81±0.2∘<annotation encoding="application / x-tex">18.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.32±0.2∘<annotation encoding="application / x-tex">21.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.80±0.2∘<annotation encoding="application / x-tex">21.80 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.01±0.2∘<annotation encoding="application / x-tex">23.01 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.37±0.2∘<annotation encoding="application / x-tex">24.37 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.50±0.2∘<annotation encoding="application / x-tex">26.50 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.90±0.2∘<annotation encoding="application / x-tex">28.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>8.44±0.2∘<annotation encoding="application / x-tex">8.44\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.00±0.2∘<annotation encoding="application / x-tex">12.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.34±0.2∘<annotation encoding="application / x-tex">12.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.16±0.2∘<annotation encoding="application / x-tex">14.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.50±0.2∘<annotation encoding="application / x-tex">15.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.50±0.2∘<annotation encoding="application / x-tex">16.50 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.74±0.2∘<annotation encoding="application / x-tex">16.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.38±0.2∘<annotation encoding="application / x-tex">18.38 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81±0.2∘<annotation encoding="application / x-tex">18.81 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.79±0.2∘<annotation encoding="application / x-tex">19.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.44±0.2∘<annotation encoding="application / x-tex">20.44 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.32±0.2∘<annotation encoding="application / x-tex">21.32 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.53±0.2∘<annotation encoding="application / x-tex">21.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.80±0.2∘<annotation encoding="application / x-tex">21.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.24±0.2∘<annotation encoding="application / x-tex">22.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.01±0.2∘<annotation encoding="application / x-tex">23.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.37±0.2∘<annotation encoding="application / x-tex">24.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.43±0.2∘<annotation encoding="application / x-tex">25.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.50±0.2∘<annotation encoding="application / x-tex">26.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.13±0.2∘<annotation encoding="application / x-tex">27.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.74±0.2∘<annotation encoding="application / x-tex">27.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.90±0.2∘<annotation encoding="application / x-tex">28.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.72±0.2∘<annotation encoding="application / x-tex">29.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.93±0.2∘<annotation encoding="application / x-tex">29.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.83±0.2∘<annotation encoding="application / x-tex">30.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.56±0.2∘<annotation encoding="application / x-tex">31.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.47±0.2∘<annotation encoding="application / x-tex">32.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.64±0.2∘<annotation encoding="application / x-tex">33.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.12±0.2∘<annotation encoding="application / x-tex">34.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>35.03±0.2∘<annotation encoding="application / x-tex">35.03\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.17±0.2∘<annotation encoding="application / x-tex">36.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the crystal form A further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the crystal form A further has one or more <com:Math><semantics>(e.g.,1,2,3,4,5,6,7,8,9,or10)2θ<annotation encoding="application / x-tex">(e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2\theta< / annotation>< / semantics>< / com:Math> angles selected from the group consisting of: <com:Math><semantics>8.44±0.2∘<annotation encoding="application / x-tex">8.44\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.00±0.2∘<annotation encoding="application / x-tex">12.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.34±0.2∘<annotation encoding="application / x-tex">12.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.50±0.2∘<annotation encoding="application / x-tex">15.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.50±0.2∘<annotation encoding="application / x-tex">16.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.38±0.2∘<annotation encoding="application / x-tex">18.38\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81±0.2∘<annotation encoding="application / x-tex">18.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.79±0.2<annotation encoding="application / x-tex">19.79 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.44±0.2<annotation encoding="application / x-tex">20.44 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.32±0.2<annotation encoding="application / x-tex">21.32 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.53±0.2<annotation encoding="application / x-tex">21.53 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.80±0.2<annotation encoding="application / x-tex">21.80 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>22.24±0.2<annotation encoding="application / x-tex">22.24 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>24.37±0.2<annotation encoding="application / x-tex">24.37 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>25.43±0.2∘<annotation encoding="application / x-tex">25.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.50±0.2∘<annotation encoding="application / x-tex">26.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.13±0.2∘<annotation encoding="application / x-tex">27.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.74±0.2∘<annotation encoding="application / x-tex">27.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.90±0.2∘<annotation encoding="application / x-tex">28.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.72±0.2∘<annotation encoding="application / x-tex">29.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.93±0.2∘<annotation encoding="application / x-tex">29.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.83±0.2∘<annotation encoding="application / x-tex">30.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.56±0.2∘<annotation encoding="application / x-tex">31.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.47±0.2∘<annotation encoding="application / x-tex">32.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.64±0.2∘<annotation encoding="application / x-tex">33.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.12±0.2∘<annotation encoding="application / x-tex">34.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>35.03±0.2∘<annotation encoding="application / x-tex">35.03\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.17±0.2∘<annotation encoding="application / x-tex">36.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>; b. the differential scanning calorimetry curve of the crystal form A has the onsets of the endothermic peaks at <com:Math><semantics>26.10∘C±2∘C<annotation encoding="application / x-tex">26.10^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>223.34∘C±2∘C<annotation encoding="application / x-tex">223.34^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>; c. the thermogravimetric analysis curve of the crystal form A has three small weight loss steps at <com:Math><semantics>24.00∘C±2∘C<annotation encoding="application / x-tex">24.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>110.00∘C±2∘C<annotation encoding="application / x-tex">110.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>200.00∘C±2∘C<annotation encoding="application / x-tex">200.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and decomposition begins above <com:Math><semantics>250.00∘C±2∘C.<annotation encoding="application / x-tex">250.00^{\circ}\text{C} \pm 2^{\circ}\text{C}.< / annotation>< / semantics>< / com:Math> In another preferred embodiment, the crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 1. In another preferred embodiment, the crystal form A has a differential scanning calorimetry pattern substantially as shown in Figure 2. In another preferred embodiment, the crystal form A has a thermogravimetric analysis pattern substantially as shown in Figure 3. In some embodiments of the present invention, the XRPD pattern of the crystal form A of the compound of Formula I-1 is shown in Figure 1. Table 1 XRPD analysis data for the crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the differential scanning calorimetry (DSC) curve of the crystal form A of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>26.10∘C±2∘C<annotation encoding="application / x-tex">26.10^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>223.34∘C±2∘C<annotation encoding="application / x-tex">223.34^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the crystal form A of the compound of Formula I-1 has a DSC pattern as shown in Figure 2. In some embodiments of the present invention, the thermogravimetric analysis (TGA) curve of crystal form A of the compound of Formula I-1 has three small weight loss steps at <com:Math><semantics>24.00∘C±2∘C<annotation encoding="application / x-tex">24.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>110.00∘C±2∘C<annotation encoding="application / x-tex">110.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>200.00∘C±2∘C<annotation encoding="application / x-tex">200.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and decomposition begins above <com:Math><semantics>250.00∘C±2∘C<annotation encoding="application / x-tex">250.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the TGA pattern of the crystal form A of the compound of Formula I-1 is as shown in Figure 3. The present invention also provides a method for preparing the crystal form A of the compound of Formula I-1, which includes adding the compound of Formula I-1 to acetonitrile, an alcoholic solvent, an ester solvent, an ether solvent, or a mixed solvent of an alcoholic solvent and water, and then performing recrystallization or slurrying to obtain it, wherein the alcoholic solvent is selected from methanol, ethanol, isopropanol, etc., the ester solvent is selected from ethyl acetate, isopropyl acetate, methyl formate, ethyl formate, isopropyl formate, etc., the ether solvent is selected from methyl tert-butyl ether, tetrahydrofuran, ethylene glycol dimethyl ether, etc, and the mixed solvent of an alcoholic solvent and water is selected from a mixture of methanol and water, a mixture of ethanol and water, or a mixture of isopropanol and water, and in the mixed solvent of an alcoholic solvent and water, the volume ratio of the alcoholic solvent to water is selected from 1:0.1 to 1.5. The present invention also provides the maleate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.82±0.2∘<annotation encoding="application / x-tex">5.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.86±0.2∘<annotation encoding="application / x-tex">9.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.29±0.2∘<annotation encoding="application / x-tex">11.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.72±0.2∘<annotation encoding="application / x-tex">12.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.04±0.2∘<annotation encoding="application / x-tex">13.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.17±0.10∘<annotation encoding="application / x-tex">15.17\pm0.10^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.88±0.2∘<annotation encoding="application / x-tex">17.88 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.11±0.2∘<annotation encoding="application / x-tex">18.11 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.28±0.2∘<annotation encoding="application / x-tex">22.28 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.02±0.2∘<annotation encoding="application / x-tex">23.02 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.42±0.2∘<annotation encoding="application / x-tex">24.42 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.34±0.2∘<annotation encoding="application / x-tex">25.34 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.77±0.29<annotation encoding="application / x-tex">26.77 \pm 0.29< / annotation>< / semantics>< / com:Math> 0.2°. In some embodiments of the present invention, the maleate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 2θ angles in its X-ray powder diffraction pattern: <com:Math><semantics>8.44±0.2∘<annotation encoding="application / x-tex">8.44\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.00±0.2∘<annotation encoding="application / x-tex">12.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.34±0.2∘<annotation encoding="application / x-tex">12.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.16±0.2∘<annotation encoding="application / x-tex">14.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.50±0.2∘<annotation encoding="application / x-tex">15.50 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.50±0.2∘<annotation encoding="application / x-tex">16.50 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.74±0.2∘<annotation encoding="application / x-tex">16.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.38±0.2∘<annotation encoding="application / x-tex">18.38 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81±0.2∘<annotation encoding="application / x-tex">18.81 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.79±0.2∘<annotation encoding="application / x-tex">19.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.44±0.2∘<annotation encoding="application / x-tex">20.44 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.32±0.2∘<annotation encoding="application / x-tex">21.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.53±0.2∘<annotation encoding="application / x-tex">21.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.80±0.2∘<annotation encoding="application / x-tex">21.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.24±0.2∘<annotation encoding="application / x-tex">22.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.01±0.2∘<annotation encoding="application / x-tex">23.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.37±0.2∘<annotation encoding="application / x-tex">24.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.43±0.2∘<annotation encoding="application / x-tex">25.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.50±0.2∘<annotation encoding="application / x-tex">26.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.13±0.2∘<annotation encoding="application / x-tex">27.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.74±0.2∘<annotation encoding="application / x-tex">27.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.90±0.2∘<annotation encoding="application / x-tex">28.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.72±0.2∘<annotation encoding="application / x-tex">29.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.93±0.2∘<annotation encoding="application / x-tex">29.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.83±0.2∘<annotation encoding="application / x-tex">30.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.56±0.2∘<annotation encoding="application / x-tex">31.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.47±0.2∘<annotation encoding="application / x-tex">32.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.64±0.2∘<annotation encoding="application / x-tex">33.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.12±0.2∘<annotation encoding="application / x-tex">34.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>35.03±0.2∘<annotation encoding="application / x-tex">35.03\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.17±0.2∘<annotation encoding="application / x-tex">36.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the maleate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 4. In some embodiments of the present invention, the XRPD pattern of the maleate crystal form A of the compound of Formula I-1 is shown in Figure 4. Table 2 XRPD analysis data for the maleate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing crystal form A of the compound of formula I-1, comprising adding the compound of formula I-1 and maleic acid to acetonitrile and dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to maleic acid is selected from 0.8 to 1.2. The present invention also provides monomaleate crystal form B of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>7.98±0.2∘<annotation encoding="application / x-tex">7.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.29±0.2∘<annotation encoding="application / x-tex">8.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.61±0.2∘<annotation encoding="application / x-tex">11.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.21±0.2∘<annotation encoding="application / x-tex">13.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.99±0.2∘<annotation encoding="application / x-tex">13.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.25<annotation encoding="application / x-tex">15.25< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.95±0.2∘<annotation encoding="application / x-tex">15.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.57±0.2∘<annotation encoding="application / x-tex">16.57 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.38±0.2∘<annotation encoding="application / x-tex">17.38 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.06±0.2∘<annotation encoding="application / x-tex">18.06 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.39±0.2∘<annotation encoding="application / x-tex">20.39 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.25±0.2∘<annotation encoding="application / x-tex">21.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.61∘<annotation encoding="application / x-tex">21.61^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 22.17 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 23.54<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 24.70<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 25.91<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 27.24<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 29.47<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 29.71<com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.64±0.2∘<annotation encoding="application / x-tex">32.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the monomaleate crystal form B of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>7.98±0.2∘<annotation encoding="application / x-tex">7.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.29±0.2∘<annotation encoding="application / x-tex">8.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.27±0.2∘<annotation encoding="application / x-tex">10.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.61±0.2∘<annotation encoding="application / x-tex">11.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.21±0.2∘<annotation encoding="application / x-tex">13.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.99±0.2∘<annotation encoding="application / x-tex">13.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.52±0.2∘<annotation encoding="application / x-tex">14.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.25±0.2∘<annotation encoding="application / x-tex">15.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.95±0.2∘<annotation encoding="application / x-tex">15.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.57±0.2∘<annotation encoding="application / x-tex">16.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.89±0.2∘<annotation encoding="application / x-tex">16.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.38±0.2∘<annotation encoding="application / x-tex">17.38\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.06±0.2∘<annotation encoding="application / x-tex">18.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.39±0.2∘<annotation encoding="application / x-tex">20.39\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.61±0.2∘<annotation encoding="application / x-tex">20.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.25±0.2∘<annotation encoding="application / x-tex">21.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.61±0.2∘<annotation encoding="application / x-tex">21.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.17±0.2∘<annotation encoding="application / x-tex">22.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.31±0.2∘<annotation encoding="application / x-tex">23.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.54±0.2∘<annotation encoding="application / x-tex">23.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.98±0.2∘<annotation encoding="application / x-tex">23.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.70±0.2∘<annotation encoding="application / x-tex">24.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.93±0.2∘<annotation encoding="application / x-tex">24.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.32±0.2∘<annotation encoding="application / x-tex">25.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.91±0.2∘<annotation encoding="application / x-tex">25.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.55±0.2∘<annotation encoding="application / x-tex">26.55\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.24±0.2∘<annotation encoding="application / x-tex">27.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.23±0.2∘<annotation encoding="application / x-tex">28.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.54±0.2∘<annotation encoding="application / x-tex">28.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.00±0.2∘<annotation encoding="application / x-tex">29.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.47±0.2∘<annotation encoding="application / x-tex">29.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.71±0.2∘<annotation encoding="application / x-tex">29.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.64±0.2∘<annotation encoding="application / x-tex">32.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>35.12±0.2∘<annotation encoding="application / x-tex">35.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the maleate crystal form B has an X-ray powder diffraction pattern substantially as shown in Figure 5. In some embodiments of the present invention, the XRPD pattern of the monomaleate crystal form B of the compound of Formula I-1 is shown in Figure 5. Table 3 X-ray diffraction data for the monomaleate crystal form B of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the monomaleate crystal form B of the compound of Formula I-1 has the onset of the endothermic peak at 213.92°C ± 2°C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the maleate crystal form B has a differential scanning calorimetry pattern substantially as shown in Figure 6. In some embodiments of the present invention, the monomaleate crystal form B of the compound of Formula I-1 has a DSC pattern as shown in Figure 6. In some embodiments of the present invention, the monomaleate crystal form B of the compound of Formula I-1 has two weight loss steps at <com:Math><semantics>24.00∘C±2∘C<annotation encoding="application / x-tex">24.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>180.00∘C±2∘C<annotation encoding="application / x-tex">180.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> in its thermogravimetric analysis (TGA) curve, and decomposition begins above <com:Math><semantics>250.00∘C±2∘C<annotation encoding="application / x-tex">250.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the maleate crystal form B has a thermogravimetric analysis pattern substantially as shown in Figure 7. In some embodiments of the present invention, the TGA pattern of the monomaleate crystal form B of the compound of Formula I-1 is shown in Figure 7. The present invention also provides a method for preparing the monomaleate crystal form B of the compound of Formula I-1, comprising adding the compound of Formula I-1 and maleic acid to tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to maleic acid is selected from 0.8 to 1.2. The present invention also provides the fumarate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.11±0.2∘<annotation encoding="application / x-tex">5.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.20±0.2∘<annotation encoding="application / x-tex">10.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.23±0.2∘<annotation encoding="application / x-tex">14.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.03±0.2∘<annotation encoding="application / x-tex">17.03\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.79±0.2∘<annotation encoding="application / x-tex">18.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.85±0.2∘<annotation encoding="application / x-tex">28.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>29.46±0.2∘<annotation encoding="application / x-tex">29.46 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the fumarate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.11±0.2∘<annotation encoding="application / x-tex">5.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.26±0.2∘<annotation encoding="application / x-tex">7.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.20±0.2∘<annotation encoding="application / x-tex">10.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.51±0.2∘<annotation encoding="application / x-tex">10.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.23±0.2∘<annotation encoding="application / x-tex">14.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.47±0.2∘<annotation encoding="application / x-tex">14.47 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.93±0.2∘<annotation encoding="application / x-tex">14.93 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.17±0.2∘<annotation encoding="application / x-tex">16.17 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.03±0.2∘<annotation encoding="application / x-tex">17.03 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.90±0.2∘<annotation encoding="application / x-tex">17.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.79±0.2∘<annotation encoding="application / x-tex">18.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.44±0.2∘<annotation encoding="application / x-tex">19.44 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.19±0.2∘<annotation encoding="application / x-tex">20.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.80±0.2∘<annotation encoding="application / x-tex">20.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.48±0.2∘<annotation encoding="application / x-tex">22.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.07±0.2∘<annotation encoding="application / x-tex">23.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.74±0.2∘<annotation encoding="application / x-tex">23.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.07±0.2∘<annotation encoding="application / x-tex">24.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.06±0.2∘<annotation encoding="application / x-tex">27.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.85±0.2∘<annotation encoding="application / x-tex">27.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.30±0.2∘<annotation encoding="application / x-tex">28.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.85±0.2∘<annotation encoding="application / x-tex">28.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.46±0.2∘<annotation encoding="application / x-tex">29.46\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>38.24±0.2∘<annotation encoding="application / x-tex">38.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the fumarate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 8. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the fumarate crystal form A of the compound of Formula I-1 is shown in Figure 8. Table 4 XRPD analysis data for the fumarate crystal form A of the compound of Formula I- [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the fumarate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and fumaric acid to acetonitrile and dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to fumaric acid is selected from 0.8 to 1.2. The present invention also provides the hemifumarate crystal form B of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>5.12±0.2∘<annotation encoding="application / x-tex">5.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.20±0.2∘<annotation encoding="application / x-tex">10.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.53±0.2∘<annotation encoding="application / x-tex">10.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.24±0.2∘<annotation encoding="application / x-tex">14.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.99±0.2∘<annotation encoding="application / x-tex">16.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81<annotation encoding="application / x-tex">18.81< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.45±0.2∘<annotation encoding="application / x-tex">19.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.22±0.2∘<annotation encoding="application / x-tex">20.22 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.43±0.2∘<annotation encoding="application / x-tex">20.43 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.84±0.2∘<annotation encoding="application / x-tex">20.84 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.04±0.2∘<annotation encoding="application / x-tex">27.04 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.904±0.2∘<annotation encoding="application / x-tex">27.904 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.254±0.2∘<annotation encoding="application / x-tex">28.254\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.754±0.2∘<annotation encoding="application / x-tex">28.754\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hemifumarate crystal form B of the compound of formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.12±0.2∘<annotation encoding="application / x-tex">5.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.27±0.2∘<annotation encoding="application / x-tex">7.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.48±0.2∘<annotation encoding="application / x-tex">7.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.77±0.2∘<annotation encoding="application / x-tex">8.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.18±0.2∘<annotation encoding="application / x-tex">9.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.74<annotation encoding="application / x-tex">9.74< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.20±0.2∘<annotation encoding="application / x-tex">10.20 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.53±0.2∘<annotation encoding="application / x-tex">10.53 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.24±0.2∘<annotation encoding="application / x-tex">14.24 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.96±0.2∘<annotation encoding="application / x-tex">14.96 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.09±0.2∘<annotation encoding="application / x-tex">16.09 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.99±0.2∘<annotation encoding="application / x-tex">16.99 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.61±0.2∘<annotation encoding="application / x-tex">17.61 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.95±0.2∘<annotation encoding="application / x-tex">17.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.81±0.2∘<annotation encoding="application / x-tex">18.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.45±0.2∘<annotation encoding="application / x-tex">19.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.22±0.2∘<annotation encoding="application / x-tex">20.22\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.43±0.2∘<annotation encoding="application / x-tex">20.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.84±0.2∘<annotation encoding="application / x-tex">20.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.51±0.2∘<annotation encoding="application / x-tex">22.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.11±0.2∘<annotation encoding="application / x-tex">23.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.76±0.2∘<annotation encoding="application / x-tex">23.76\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.19±0.2∘<annotation encoding="application / x-tex">24.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.24±0.2∘<annotation encoding="application / x-tex">25.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.04±0.2∘<annotation encoding="application / x-tex">27.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.90±0.2∘<annotation encoding="application / x-tex">27.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.25±0.2∘<annotation encoding="application / x-tex">28.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.75±0.2∘<annotation encoding="application / x-tex">28.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.73±0.2∘<annotation encoding="application / x-tex">29.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.14±0.2∘<annotation encoding="application / x-tex">30.14\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.77±0.2∘<annotation encoding="application / x-tex">30.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.28±0.2∘<annotation encoding="application / x-tex">31.28\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.95±0.2∘<annotation encoding="application / x-tex">33.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.52±0.2∘<annotation encoding="application / x-tex">34.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>37.07±0.2∘<annotation encoding="application / x-tex">37.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>38.26±0.2∘<annotation encoding="application / x-tex">38.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hemifumarate crystal form B has an X-ray powder diffraction pattern substantially as shown in Figure 9. In some embodiments of the present invention, the XRPD pattern of the hemifumarate crystal form B of the compound of Formula I-1 is shown in Figure 9. Table 5 XRPD analysis data for the hemifumarate crystal form B of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hemifumarate crystal form B of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>21.34∘C±2∘C<annotation encoding="application / x-tex">21.34^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>172.21∘C<annotation encoding="application / x-tex">172.21^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±<annotation encoding="application / x-tex">\pm< / annotation>< / semantics>< / com:Math> 2°C, and 234.34°C <com:Math><semantics>±<annotation encoding="application / x-tex">\pm< / annotation>< / semantics>< / com:Math> 2°C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the hemifumarate crystal form B has a differential scanning calorimetry pattern substantially as shown in Figure 10. In some embodiments of the present invention, the hemifumarate crystal form B of the compound of Formula I-1 has a DSC pattern as shown in Figure 10. In some embodiments of the present invention, the hemifumarate crystal form B of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>31.90∘C±2∘C<annotation encoding="application / x-tex">31.90^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>90.00∘C±2∘C<annotation encoding="application / x-tex">90.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and 190.00°C ± 2°C in its thermogravimetric analysis (TGA) curve, and decomposition begins above <com:Math><semantics>270.00∘C±2∘C<annotation encoding="application / x-tex">270.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hemifumarate crystal form B has a thermogravimetric analysis pattern substantially as shown in Figure 11. In some embodiments of the present invention, the TGA pattern of the hemifumarate crystal form B of the compound of Formula I-1 is shown in Figure 11. The present invention also provides a method for preparing the hemifumarate crystal form B of the compound of Formula I-1, comprising adding the compound of Formula I-1 and fumaric acid to tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to fumaric acid is selected from 1.6 to 2.4. The present invention also provides the monoglycolate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.37±0.2∘<annotation encoding="application / x-tex">6.37 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.37±0.2∘<annotation encoding="application / x-tex">10.37 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.69±0.2∘<annotation encoding="application / x-tex">12.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.55±0.2∘<annotation encoding="application / x-tex">13.55 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.06±0.2∘<annotation encoding="application / x-tex">14.06 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.22±0.2∘<annotation encoding="application / x-tex">18.22 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.47±0.2∘<annotation encoding="application / x-tex">18.47 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.25±0.2∘<annotation encoding="application / x-tex">21.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.83±0.2∘<annotation encoding="application / x-tex">22.83 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.49±0.2∘<annotation encoding="application / x-tex">23.49 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.41±0.2∘<annotation encoding="application / x-tex">26.41 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.96±0.2∘<annotation encoding="application / x-tex">30.96 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the monoglycolate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.37±0.2∘<annotation encoding="application / x-tex">6.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.37±0.2∘<annotation encoding="application / x-tex">10.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.09±0.2∘<annotation encoding="application / x-tex">11.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.70±0.2∘<annotation encoding="application / x-tex">11.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.69±0.2∘<annotation encoding="application / x-tex">12.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.55±0.2∘<annotation encoding="application / x-tex">13.55 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.06±0.2∘<annotation encoding="application / x-tex">14.06 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.97±0.2∘<annotation encoding="application / x-tex">15.97 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.34±0.2∘<annotation encoding="application / x-tex">17.34 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.22±0.2∘<annotation encoding="application / x-tex">18.22 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.47±0.2∘<annotation encoding="application / x-tex">18.47 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.09±0.2∘<annotation encoding="application / x-tex">19.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.71±0.2∘<annotation encoding="application / x-tex">20.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.25±0.2∘<annotation encoding="application / x-tex">21.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.06±0.2∘<annotation encoding="application / x-tex">22.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.43±0.2∘<annotation encoding="application / x-tex">22.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.83±0.2∘<annotation encoding="application / x-tex">22.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.49±0.2∘<annotation encoding="application / x-tex">23.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.09±0.2∘<annotation encoding="application / x-tex">24.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.79±0.2∘<annotation encoding="application / x-tex">24.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.21±0.2∘<annotation encoding="application / x-tex">25.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.41±0.2∘<annotation encoding="application / x-tex">26.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.23±0.2∘<annotation encoding="application / x-tex">27.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.00±0.2∘<annotation encoding="application / x-tex">28.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.59±0.2∘<annotation encoding="application / x-tex">29.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.44±0.2∘<annotation encoding="application / x-tex">30.44\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.96±0.2∘<annotation encoding="application / x-tex">30.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>38.67±0.2∘<annotation encoding="application / x-tex">38.67\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the monoglycolate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 12. In some embodiments of the present invention, the XRPD pattern of the monoglycolate crystal form A of the compound of Formula I-1 is shown in Figure 12. Table 6 XRPD analysis data for the monoglycolate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the monoglycolate crystal form A of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>109.66∘C±2∘C<annotation encoding="application / x-tex">109.66^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>198.83∘<annotation encoding="application / x-tex">198.83^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the monoglycolate crystal form A has a differential scanning calorimetry pattern substantially as shown in Figure 13. In some embodiments of the present invention, the monoglycolate crystal form A of the compound of Formula I-1 has a DSC pattern as shown in Figure 13. In some embodiments of the present invention, the monoglycolate crystal form A of the compound of Formula I-1 has three weight loss steps at 33.00°C ± 2°C, 100.00°C ± 2°C, and 165.00°C ± 2°C in its thermogravimetric analysis (TGA) curve, and decomposition begins above <com:Math><semantics>200.00∘C±2∘C<annotation encoding="application / x-tex">200.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the monoglycolate crystal form A has a thermogravimetric analysis pattern substantially as shown in Figure 14. In some embodiments of the present invention, the TGA pattern of the monoglycolate crystal form A of the compound of Formula I-1 is shown in Figure 14. The present invention also provides a method for preparing the monoglycolate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and glycolic acid to acetonitrile, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to glycolic acid is selected from 0.8 to 1.2. The present invention also provides the glycolate crystal form B of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.95±0.2∘<annotation encoding="application / x-tex">5.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.20±0.2∘<annotation encoding="application / x-tex">12.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.87±0.2∘<annotation encoding="application / x-tex">13.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.79±0.2∘<annotation encoding="application / x-tex">15.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.97±0.2∘<annotation encoding="application / x-tex">15.97\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.44<annotation encoding="application / x-tex">16.44< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.63±0.2∘<annotation encoding="application / x-tex">16.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.79±0.2∘<annotation encoding="application / x-tex">16.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.30±0.2∘<annotation encoding="application / x-tex">17.30 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.49±0.2∘<annotation encoding="application / x-tex">19.49 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.50±0.2∘<annotation encoding="application / x-tex">23.50 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.68±0.2∘<annotation encoding="application / x-tex">26.68 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the glycolate crystal form B of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>5.95±0.2∘<annotation encoding="application / x-tex">5.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.06±0.2∘<annotation encoding="application / x-tex">11.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.20±0.2∘<annotation encoding="application / x-tex">12.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.87±0.2∘<annotation encoding="application / x-tex">13.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.01±0.2∘<annotation encoding="application / x-tex">15.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.79±0.2∘<annotation encoding="application / x-tex">15.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.97±0.2∘<annotation encoding="application / x-tex">15.97\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.44±0.2∘<annotation encoding="application / x-tex">16.44\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.63±0.2∘<annotation encoding="application / x-tex">16.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.79±0.2∘<annotation encoding="application / x-tex">16.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.30±0.2∘<annotation encoding="application / x-tex">17.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.90±0.2∘<annotation encoding="application / x-tex">17.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$18.33\pm0.2^{\circ}, \quad 18.91\pm0.2^{\circ}, \quad 19.49\pm0.2^{\circ}, \quad 21.59\pm0.2^{\circ}, \quad 22.18\pm0.2^{\circ}, \quad 22.80\pm0.2^{\circ}, \quad 23.16\pm0.2^{\circ}, \\ 23.50\pm0.2^{\circ}, \quad 23.93\pm0.2^{\circ}, \quad 24.49\pm0.2^{\circ}, \quad 25.13\pm0.2^{\circ}, \quad 26.68\pm0.2^{\circ}, \quad 27.95\pm0.2^{\circ}, \quad$ <com:Math><semantics>31.62±0.2∘<annotation encoding="application / x-tex">31.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.27±0.2∘<annotation encoding="application / x-tex">32.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the glycolate crystal form B has an X-ray powder diffraction pattern substantially as shown in Figure 15. In some embodiments of the present invention, the XRPD pattern of the glycolate crystal form B of the compound of Formula I-1 is shown in Figure 15. Table 7 XRPD analysis data for the glycolate crystal form B of the compound of Formula I- [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the glycolate crystal form B of the compound of Formular I-1, comprising adding the compound of Formula I-1 and glycolic acid to tetrahydrofuran and dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to glycolic acid is selected from 0.8 to 1.2. The present invention also provides the mono-L-malate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.01±0.2∘<annotation encoding="application / x-tex">6.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.15±0.2∘<annotation encoding="application / x-tex">15.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.27±0.2∘<annotation encoding="application / x-tex">17.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.99±0.2∘<annotation encoding="application / x-tex">17.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.58±0.2∘<annotation encoding="application / x-tex">18.58\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.58<annotation encoding="application / x-tex">22.58< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 24.00 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 24.50 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 25.00 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 29.40 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 30.53 <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the mono-L-malate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.01±0.2∘<annotation encoding="application / x-tex">6.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.06±0.2∘<annotation encoding="application / x-tex">10.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.04±0.2∘<annotation encoding="application / x-tex">11.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.98±0.2∘<annotation encoding="application / x-tex">11.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.66±0.2∘<annotation encoding="application / x-tex">12.66 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.86±0.2∘<annotation encoding="application / x-tex">12.86 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.39±0.2∘<annotation encoding="application / x-tex">13.39 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.15±0.2∘<annotation encoding="application / x-tex">15.15 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.62±0.2∘<annotation encoding="application / x-tex">15.62 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.46±0.2∘<annotation encoding="application / x-tex">16.46 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.27±0.2∘<annotation encoding="application / x-tex">17.27 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.99±0.2∘<annotation encoding="application / x-tex">17.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.58±0.2∘<annotation encoding="application / x-tex">18.58\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.53±0.2∘<annotation encoding="application / x-tex">19.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.77±0.2∘<annotation encoding="application / x-tex">19.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.25±0.2∘<annotation encoding="application / x-tex">20.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.01±0.2∘<annotation encoding="application / x-tex">21.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.57±0.2∘<annotation encoding="application / x-tex">21.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.04±0.2∘<annotation encoding="application / x-tex">22.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.58±0.2∘<annotation encoding="application / x-tex">22.58\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.67±0.2∘<annotation encoding="application / x-tex">23.67\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.00±0.2∘<annotation encoding="application / x-tex">24.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.50±0.2∘<annotation encoding="application / x-tex">24.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.00±0.2∘<annotation encoding="application / x-tex">25.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.34±0.2∘<annotation encoding="application / x-tex">27.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.54±0.2∘<annotation encoding="application / x-tex">28.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.91±0.2∘<annotation encoding="application / x-tex">28.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.40±0.2∘<annotation encoding="application / x-tex">29.40\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.89±0.2∘<annotation encoding="application / x-tex">29.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.53±0.2∘<annotation encoding="application / x-tex">30.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.33±0.2∘<annotation encoding="application / x-tex">31.33\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.67±0.2∘<annotation encoding="application / x-tex">33.67\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.16±0.2∘<annotation encoding="application / x-tex">36.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the mono-L-malate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 16. In some embodiments of the present invention, the XRPD pattern of the mono-L-malate crystal form A of the compound of Formula I-1 is shown in Figure 16. Table 8. XRPD analysis data for the mono-L-malate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the mono-L-malate crystal form A of the compound of Formula I-1 has the onset of endothermic peak at 204.74°C ± 2°C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the mono-L-malate crystal form A has a differential scanning calorimetry pattern substantially as shown in Figure 17. In some embodiments of the present invention, the DSC pattern of the mono-L-malate crystal form A of the compound of Formula I-1 is shown in Figure 17. In some embodiments of the present invention, the mono-L-malate crystal form A of the compound of Formula I-1 has two weight loss steps at 33.00°C ± 2°C and 185.00°C ± 2°C in its thermogravimetric analysis (TGA) curve, and decomposition begins above <com:Math><semantics>250.00∘C±2∘C<annotation encoding="application / x-tex">250.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the mono-L-malate crystal form A has a thermogravimetric analysis pattern substantially as shown in Figure 18. In some embodiments of the present invention, the TGA pattern of mono-L-malate crystal form A of the compound of Formula I-1 is shown in Figure 18. The present invention also provides a method for preparing the mono-L-malate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and L-malic acid to acetonitrile, tetrahydrofuran, and dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to L-malic acid is selected from 0.8 to 1.2. The present invention also provides the monosuccinate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.15±0.2∘<annotation encoding="application / x-tex">6.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.26±0.2∘<annotation encoding="application / x-tex">12.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.59±0.2∘<annotation encoding="application / x-tex">17.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.40±0.2∘<annotation encoding="application / x-tex">18.40\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.89±0.2∘<annotation encoding="application / x-tex">18.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.11±0.2∘<annotation encoding="application / x-tex">19.11 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.73±0.2∘<annotation encoding="application / x-tex">19.73 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.90±0.2∘<annotation encoding="application / x-tex">20.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.12±0.2∘<annotation encoding="application / x-tex">23.12 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.83±0.2∘<annotation encoding="application / x-tex">23.83 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.09±0.2∘<annotation encoding="application / x-tex">24.09 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.35±0.2∘<annotation encoding="application / x-tex">24.35 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.62±0.2∘<annotation encoding="application / x-tex">24.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.93±0.2∘<annotation encoding="application / x-tex">24.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.17±0.2∘<annotation encoding="application / x-tex">25.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the monosuccinate crystal form A of the compound of formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.15±0.2∘<annotation encoding="application / x-tex">6.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.64±0.2∘<annotation encoding="application / x-tex">9.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.95±0.2∘<annotation encoding="application / x-tex">9.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.19±0.2∘<annotation encoding="application / x-tex">11.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.26±0.2∘<annotation encoding="application / x-tex">12.26 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.70±0.2∘<annotation encoding="application / x-tex">12.70 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.30±0.2∘<annotation encoding="application / x-tex">13.30 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.95±0.2∘<annotation encoding="application / x-tex">14.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.25±0.2∘<annotation encoding="application / x-tex">15.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.18±0.2∘<annotation encoding="application / x-tex">16.18 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.59±0.2∘<annotation encoding="application / x-tex">17.59 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.40±0.2∘<annotation encoding="application / x-tex">18.40\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.89±0.2∘<annotation encoding="application / x-tex">18.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.11±0.2∘<annotation encoding="application / x-tex">19.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.73±0.2∘<annotation encoding="application / x-tex">19.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.28±0.2∘<annotation encoding="application / x-tex">20.28\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.90±0.2∘<annotation encoding="application / x-tex">20.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.27±0.2∘<annotation encoding="application / x-tex">21.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.64±0.2∘<annotation encoding="application / x-tex">21.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.12±0.2∘<annotation encoding="application / x-tex">22.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.12±0.2∘<annotation encoding="application / x-tex">23.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.83±0.2∘<annotation encoding="application / x-tex">23.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.09±0.2∘<annotation encoding="application / x-tex">24.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.35±0.2∘<annotation encoding="application / x-tex">24.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.62±0.2∘<annotation encoding="application / x-tex">24.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.93±0.2∘<annotation encoding="application / x-tex">24.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.17±0.2∘<annotation encoding="application / x-tex">25.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.05±0.2∘<annotation encoding="application / x-tex">26.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.00±0.2∘<annotation encoding="application / x-tex">27.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.27±0.2∘<annotation encoding="application / x-tex">28.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.72±0.2∘<annotation encoding="application / x-tex">28.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.12±0.2∘<annotation encoding="application / x-tex">30.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.20±0.2∘<annotation encoding="application / x-tex">31.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.57±0.2∘<annotation encoding="application / x-tex">33.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.13±0.2∘<annotation encoding="application / x-tex">34.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.58±0.2∘<annotation encoding="application / x-tex">34.58\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>35.60±0.2∘<annotation encoding="application / x-tex">35.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>38.23±0.2∘<annotation encoding="application / x-tex">38.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the monosuccinate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 19. In some embodiments of the present invention, the XRPD pattern of the monosuccinate crystal form A of the compound of Formula I-1 is shown in Figure 19. Table 9: XRPD analysis data for the monosuccinate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the monosuccinate crystal form A of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>72.75∘C±2∘C<annotation encoding="application / x-tex">72.75^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>146.41∘C<annotation encoding="application / x-tex">146.41^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±2<annotation encoding="application / x-tex">\pm 2< / annotation>< / semantics>< / com:Math>°C, and <com:Math><semantics>175.72<annotation encoding="application / x-tex">175.72< / annotation>< / semantics>< / com:Math>°C <com:Math><semantics>±2<annotation encoding="application / x-tex">\pm 2< / annotation>< / semantics>< / com:Math>°C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the monosuccinate crystal form A has a differential scanning calorimetry pattern substantially as shown in Figure 20. In some embodiments of the present invention, the DSC pattern of the monosuccinate crystal form A of the compound of Formula I-1 is shown in Figure 20. In some embodiments of the present invention, the monosuccinate crystal form A of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>33.00∘C±2∘C<annotation encoding="application / x-tex">33.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>90.00∘C±2∘C<annotation encoding="application / x-tex">90.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, and 160.00°C ± 2°C in its thermogravimetric analysis (TGA) curve, and decomposition begins above <com:Math><semantics>260.00∘C±2∘C<annotation encoding="application / x-tex">260.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the monosuccinate crystal form A has a thermogravimetric analysis pattern substantially as shown in Figure 21. In some embodiments of the present invention, the TGA pattern of the monosuccinate crystal form A of the compound of Formula I-1 is shown in Figure 21. The present invention also provides a method for preparing the monosuccinate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and succinic acid to acetonitrile, tetrahydrofuran, dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to succinic acid is selected from 0.8 to 1.2. The present invention also provides the sulfate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.74±0.2∘<annotation encoding="application / x-tex">6.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.56±0.2∘<annotation encoding="application / x-tex">9.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.89±0.2∘<annotation encoding="application / x-tex">12.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.78±0.2∘<annotation encoding="application / x-tex">13.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.97±0.2∘<annotation encoding="application / x-tex">14.97\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.70±0.2∘<annotation encoding="application / x-tex">15.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.68±0.2∘<annotation encoding="application / x-tex">18.68 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.87±0.2∘<annotation encoding="application / x-tex">19.87 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.21±0.2∘<annotation encoding="application / x-tex">20.21 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.54±0.2∘<annotation encoding="application / x-tex">21.54 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.76±0.2∘<annotation encoding="application / x-tex">21.76 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.58±0.2∘<annotation encoding="application / x-tex">22.58 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.75±0.2∘<annotation encoding="application / x-tex">23.75 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.11±0.2∘<annotation encoding="application / x-tex">24.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.50±0.2∘<annotation encoding="application / x-tex">24.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.25±0.2∘<annotation encoding="application / x-tex">25.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.86±0.2∘<annotation encoding="application / x-tex">25.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.73±0.2∘<annotation encoding="application / x-tex">27.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.41±0.2∘<annotation encoding="application / x-tex">28.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.70±0.2∘<annotation encoding="application / x-tex">29.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.21±0.2∘<annotation encoding="application / x-tex">30.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.99±0.2∘<annotation encoding="application / x-tex">30.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the sulfate crystal form A of the compound of formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.74±0.2∘<annotation encoding="application / x-tex">6.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.56±0.2∘<annotation encoding="application / x-tex">9.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.89±0.2∘<annotation encoding="application / x-tex">12.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.78±0.2∘<annotation encoding="application / x-tex">13.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.68±0.2∘<annotation encoding="application / x-tex">14.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.97±0.2∘<annotation encoding="application / x-tex">14.97 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.49±0.2∘<annotation encoding="application / x-tex">15.49 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.70±0.2∘<annotation encoding="application / x-tex">15.70 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.41±0.2∘<annotation encoding="application / x-tex">16.41 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.90±0.2∘<annotation encoding="application / x-tex">16.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.47±0.2∘<annotation encoding="application / x-tex">18.47 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.68±0.2∘<annotation encoding="application / x-tex">18.68 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$18.86\pm0.2^{\circ}, \quad 19.33\pm0.2^{\circ}, \quad 19.87\pm0.2^{\circ}, \quad 20.21\pm0.2^{\circ}, \quad 20.70\pm0.2^{\circ}, \quad 21.54\pm0.2^{\circ}, \quad 21.76\pm0.2^{\circ}, \\ 22.25\pm0.2^{\circ}, \quad 22.58\pm0.2^{\circ}, \quad 23.75\pm0.2^{\circ}, \quad 24.11\pm0.2^{\circ}, \quad 24.50\pm0.2^{\circ}, \quad 25.25\pm0.2^{\circ}, \quad$ <com:Math><semantics>26.10±0.2∘<annotation encoding="application / x-tex">26.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.71±0.2∘<annotation encoding="application / x-tex">26.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.96±0.2∘<annotation encoding="application / x-tex">26.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.73±0.2∘<annotation encoding="application / x-tex">27.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.41±0.2∘<annotation encoding="application / x-tex">28.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.90±0.2∘<annotation encoding="application / x-tex">28.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.70±0.2∘<annotation encoding="application / x-tex">29.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.21±0.2∘<annotation encoding="application / x-tex">30.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.99±0.2∘<annotation encoding="application / x-tex">30.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the sulfate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 22. In some embodiments of the present invention, the XRPD pattern of sulfate crystal form A of the compound of Formula I-1 is shown in Figure 22. Table 10 XRPD analysis data for the sulfate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the sulfate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and sulfuric acid to acetonitrile, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to sulfuric acid is selected from 0.8 to 1.2. The present invention also provides the L-tartarate crystral form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.53±0.2∘<annotation encoding="application / x-tex">5.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.90±0.2∘<annotation encoding="application / x-tex">8.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.35±0.2∘<annotation encoding="application / x-tex">9.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.05±0.2∘<annotation encoding="application / x-tex">11.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.54±0.2∘<annotation encoding="application / x-tex">12.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.90±0.2∘<annotation encoding="application / x-tex">12.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.35±0.2∘<annotation encoding="application / x-tex">14.35 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.64±0.2∘<annotation encoding="application / x-tex">14.64 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.95±0.2∘<annotation encoding="application / x-tex">16.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.70±0.2∘<annotation encoding="application / x-tex">18.70 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.45±0.2∘<annotation encoding="application / x-tex">19.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.74±0.2∘<annotation encoding="application / x-tex">19.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.38±0.2∘<annotation encoding="application / x-tex">20.38 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.79±0.2∘<annotation encoding="application / x-tex">20.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.45±0.2∘<annotation encoding="application / x-tex">21.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.94±0.2∘<annotation encoding="application / x-tex">21.94\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.88±0.2∘<annotation encoding="application / x-tex">22.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.80±0.2∘<annotation encoding="application / x-tex">23.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.01±0.2∘<annotation encoding="application / x-tex">25.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.77±0.2∘<annotation encoding="application / x-tex">25.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.33±0.2∘<annotation encoding="application / x-tex">27.33\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.80±0.2∘<annotation encoding="application / x-tex">27.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.65±0.2∘<annotation encoding="application / x-tex">28.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.41±0.2∘<annotation encoding="application / x-tex">29.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.00±0.2∘<annotation encoding="application / x-tex">30.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.09±0.2∘<annotation encoding="application / x-tex">31.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the L-tartarate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>5.53±0.2∘<annotation encoding="application / x-tex">5.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.90±0.2∘<annotation encoding="application / x-tex">8.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.35±0.2∘<annotation encoding="application / x-tex">9.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.05±0.2∘<annotation encoding="application / x-tex">11.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.54±0.2∘<annotation encoding="application / x-tex">12.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.90±0.2∘<annotation encoding="application / x-tex">12.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.35±0.2∘<annotation encoding="application / x-tex">14.35 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.64±0.2∘<annotation encoding="application / x-tex">14.64 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.95±0.2∘<annotation encoding="application / x-tex">16.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.70±0.2∘<annotation encoding="application / x-tex">18.70 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.45±0.2∘<annotation encoding="application / x-tex">19.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.74±0.2∘<annotation encoding="application / x-tex">19.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.38±0.2∘<annotation encoding="application / x-tex">20.38\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.79±0.2∘<annotation encoding="application / x-tex">20.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.45±0.2∘<annotation encoding="application / x-tex">21.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.94±0.2∘<annotation encoding="application / x-tex">21.94\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.88±0.2∘<annotation encoding="application / x-tex">22.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.80±0.2∘<annotation encoding="application / x-tex">23.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.01±0.2∘<annotation encoding="application / x-tex">25.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.77±0.2∘<annotation encoding="application / x-tex">25.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.33±0.2∘<annotation encoding="application / x-tex">27.33\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.80±0.2∘<annotation encoding="application / x-tex">27.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.65±0.2∘<annotation encoding="application / x-tex">28.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.41±0.2∘<annotation encoding="application / x-tex">29.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.00±0.2∘<annotation encoding="application / x-tex">30.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.09±0.2∘<annotation encoding="application / x-tex">31.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the L-tartarate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 23. In some embodiments of the present invention, the XRPD pattern of the L-tartrate crystal form A of the compound of Formula I-1 is shown in Figure 23. Table 11 XRPD analysis data for the L-tartrate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the L-tartarate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and L- tartaric acid to acetonitrile, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to L-tartaric acid is selected from 0.8 to 1.2. The present invention also provides the hippurate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.17±0.2∘<annotation encoding="application / x-tex">6.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>6.52±0.2∘<annotation encoding="application / x-tex">6.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.30±0.2∘<annotation encoding="application / x-tex">12.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.18±0.2∘<annotation encoding="application / x-tex">14.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.62±0.2∘<annotation encoding="application / x-tex">15.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.06±0.2∘<annotation encoding="application / x-tex">16.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.78±0.2∘<annotation encoding="application / x-tex">16.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.64±0.2∘<annotation encoding="application / x-tex">17.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.78±0.2∘<annotation encoding="application / x-tex">18.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.42±0.2∘<annotation encoding="application / x-tex">20.42\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.15±0.2∘<annotation encoding="application / x-tex">21.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.29±0.2∘<annotation encoding="application / x-tex">21.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.79±0.2∘<annotation encoding="application / x-tex">21.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.42±0.2∘<annotation encoding="application / x-tex">24.42\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.45±0.2∘<annotation encoding="application / x-tex">26.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hippurate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.17±0.2∘<annotation encoding="application / x-tex">6.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>6.52±0.2∘<annotation encoding="application / x-tex">6.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.77±0.2∘<annotation encoding="application / x-tex">8.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.74±0.2∘<annotation encoding="application / x-tex">10.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.16±0.2∘<annotation encoding="application / x-tex">11.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.30±0.2∘<annotation encoding="application / x-tex">12.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.18±0.2∘<annotation encoding="application / x-tex">14.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.70±0.2∘<annotation encoding="application / x-tex">14.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.62±0.2∘<annotation encoding="application / x-tex">15.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.06±0.2∘<annotation encoding="application / x-tex">16.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.78±0.2∘<annotation encoding="application / x-tex">16.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.64±0.2∘<annotation encoding="application / x-tex">17.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.78±0.2∘<annotation encoding="application / x-tex">18.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.42±0.2∘<annotation encoding="application / x-tex">20.42\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.15±0.2∘<annotation encoding="application / x-tex">21.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.29±0.2∘<annotation encoding="application / x-tex">21.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.79±0.2∘<annotation encoding="application / x-tex">21.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.03±0.2∘<annotation encoding="application / x-tex">23.03\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.05±0.2∘<annotation encoding="application / x-tex">24.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.42±0.2∘<annotation encoding="application / x-tex">24.42\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.32±0.2∘<annotation encoding="application / x-tex">25.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.45±0.2∘<annotation encoding="application / x-tex">26.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.87±0.2∘<annotation encoding="application / x-tex">26.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.85±0.2∘<annotation encoding="application / x-tex">28.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hippurate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 24. In some embodiments of the present invention, the XRPD pattern of the hippurate crystal form A of the compound of Formula I-1 is shown in Figure 24. Table 12 XRPD analysis data for the hippurate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the hippurate crystal form A of compound of Formula I-1, comprising adding the compound of Formula I-1 and hippuric acid to tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of compound of Formula I-1 to hippuric acid is selected from 0.8 to 1.2. The present invention also provides the glutarate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>11.82±0.2∘<annotation encoding="application / x-tex">11.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.75±0.2∘<annotation encoding="application / x-tex">12.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.19±0.2∘<annotation encoding="application / x-tex">13.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.87±0.2∘<annotation encoding="application / x-tex">14.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.10±0.2∘<annotation encoding="application / x-tex">15.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.10±0.2∘<annotation encoding="application / x-tex">17.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.82±0.2∘<annotation encoding="application / x-tex">17.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.35±0.2∘<annotation encoding="application / x-tex">18.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.75±0.2∘<annotation encoding="application / x-tex">19.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.14±0.2∘<annotation encoding="application / x-tex">20.14\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.70±0.2∘<annotation encoding="application / x-tex">20.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.23±0.2∘<annotation encoding="application / x-tex">22.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.20±0.2∘<annotation encoding="application / x-tex">23.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.26±0.2∘<annotation encoding="application / x-tex">24.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.47±0.2∘<annotation encoding="application / x-tex">24.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.92±0.2∘<annotation encoding="application / x-tex">29.92\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the glutarate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>9.86±0.2∘<annotation encoding="application / x-tex">9.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.97±0.2∘<annotation encoding="application / x-tex">10.97\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.82±0.2∘<annotation encoding="application / x-tex">11.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.29±0.2∘<annotation encoding="application / x-tex">12.29\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.75±0.2∘<annotation encoding="application / x-tex">12.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.19±0.2∘<annotation encoding="application / x-tex">13.19 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.87±0.2∘<annotation encoding="application / x-tex">14.87 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.10±0.2∘<annotation encoding="application / x-tex">15.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.37±0.2∘<annotation encoding="application / x-tex">15.37 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.33±0.2∘<annotation encoding="application / x-tex">16.33 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.10±0.2∘<annotation encoding="application / x-tex">17.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.82±0.2∘<annotation encoding="application / x-tex">17.82 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.35±0.2∘<annotation encoding="application / x-tex">18.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.17±0.2∘<annotation encoding="application / x-tex">19.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.75±0.2∘<annotation encoding="application / x-tex">19.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.14±0.2∘<annotation encoding="application / x-tex">20.14\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.70±0.2∘<annotation encoding="application / x-tex">20.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.14±0.2∘<annotation encoding="application / x-tex">21.14\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.23±0.2∘<annotation encoding="application / x-tex">22.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.20±0.2∘<annotation encoding="application / x-tex">23.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.26±0.2∘<annotation encoding="application / x-tex">24.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.47±0.2∘<annotation encoding="application / x-tex">24.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.86±0.2∘<annotation encoding="application / x-tex">24.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.28±0.2∘<annotation encoding="application / x-tex">25.28\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.92±0.2∘<annotation encoding="application / x-tex">29.92\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the glutarate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 25. In some embodiments of the present invention, the XRPD pattern of the glutarate crystal form A of the compound of Formula I-1 is shown in Figure 25. Table 13 XRPD analysis data for the glutarate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the glutarate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and glutaric acid to acetonitrile and dichloromethane, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to glutaric acid is selected from 0.8 to 1.2. The present invention also provides the p-toluenesulfonate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>7.08±0.2∘<annotation encoding="application / x-tex">7.08\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.23±0.2∘<annotation encoding="application / x-tex">10.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.36±0.2∘<annotation encoding="application / x-tex">13.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.16±0.2∘<annotation encoding="application / x-tex">14.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.77±0.2∘<annotation encoding="application / x-tex">17.77 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.10±0.2∘<annotation encoding="application / x-tex">18.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.90±0.2∘<annotation encoding="application / x-tex">18.90 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.12±0.2∘<annotation encoding="application / x-tex">19.12 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.11±0.2∘<annotation encoding="application / x-tex">20.11 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.53±0.2∘<annotation encoding="application / x-tex">20.53 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.91±0.2∘<annotation encoding="application / x-tex">20.91 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 24.41±0.2°, 25.51±0.2°, 28.28±0.2°, 29.95±0.2°, 30.98±0.2°, 35.22±0.2°. In some embodiments of the present invention, the X-ray powder diffraction pattern of the p-toluenesulfonate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 2θ angles: 7.08±0.2°, 8.00±0.2°, 9.39±0.2°, 10.23±0.2°, <com:Math><semantics>13.36±0.2∘<annotation encoding="application / x-tex">13.36 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.16±0.2∘<annotation encoding="application / x-tex">14.16 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.81±0.2∘<annotation encoding="application / x-tex">14.81 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.77±0.2∘<annotation encoding="application / x-tex">15.77 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.21±0.2∘<annotation encoding="application / x-tex">16.21 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.77±0.2∘<annotation encoding="application / x-tex">17.77 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.10±0.2∘<annotation encoding="application / x-tex">18.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$18.90\pm0.2^{\circ}, \quad 19.12\pm0.2^{\circ}, \quad 20.11\pm0.2^{\circ}, \quad 20.53\pm0.2^{\circ}, \quad 20.91\pm0.2^{\circ}, \quad 21.29\pm0.2^{\circ}, \quad 22.49\pm0.2^{\circ}, \\ 23.11\pm0.2^{\circ}, \quad 24.41\pm0.2^{\circ}, \quad 25.51\pm0.2^{\circ}, \quad 26.77\pm0.2^{\circ}, \quad 28.28\pm0.2^{\circ}, \quad 28.81\pm0.2^{\circ}, \quad$ 29.95±0.2°, 30.98±0.2°, 35.22±0.2°. In another preferred embodiment, the p-toluenesulfonate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 26. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the p-toluenesulfonate crystal form A of the compound of Formula I-1 is shown in Figure 26. Table 14 XRPD analysis data for the p-toluenesulfonate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the p-toluenesulfonate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and p-toluenesulfonic acid to acetonitrile, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to p-toluenesulfonic acid is selected from 0.8 to 1.2. The present invention also provides the p-toluenesulfonate crystal form B of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>8.27±0.2∘<annotation encoding="application / x-tex">8.27 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.69±0.2∘<annotation encoding="application / x-tex">13.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.95±0.2∘<annotation encoding="application / x-tex">13.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.15±0.15<annotation encoding="application / x-tex">16.15 \pm 0.15< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.72±0.2∘<annotation encoding="application / x-tex">17.72 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.52±0.2∘<annotation encoding="application / x-tex">19.52 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.05±0.2∘<annotation encoding="application / x-tex">21.05 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.45±0.2∘<annotation encoding="application / x-tex">22.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.91±0.2∘<annotation encoding="application / x-tex">23.91 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.40±0.2∘<annotation encoding="application / x-tex">25.40 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.33±0.2∘<annotation encoding="application / x-tex">27.33 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.25±0.∘<annotation encoding="application / x-tex">29.25 \pm 0.^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the p-toluenesulfonate crystal form B of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>8.27±0.2∘<annotation encoding="application / x-tex">8.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.59±0.2∘<annotation encoding="application / x-tex">12.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.69±0.2∘<annotation encoding="application / x-tex">13.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.95±0.2∘<annotation encoding="application / x-tex">13.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.63±0.2<annotation encoding="application / x-tex">14.63 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>16.15±0.2<annotation encoding="application / x-tex">16.15 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>17.72±0.2<annotation encoding="application / x-tex">17.72 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>18.68±0.2<annotation encoding="application / x-tex">18.68 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>19.52±0.2<annotation encoding="application / x-tex">19.52 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.75±0.2<annotation encoding="application / x-tex">20.75 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.05±0.2<annotation encoding="application / x-tex">21.05 \pm 0.2< / annotation>< / semantics>< / com:Math>°, 21.92±0.2°, 22.45±0.2°, 23.23±0.2°, 23.91±0.2°, 25.40±0.2°, 27.33±0.2°, 29.25±0.2°. In another preferred embodiment, the p-toluenesulfonate crystal form B has an X-ray powder diffraction pattern substantially as shown in Figure 27. In some embodiments of the present invention, the XRPD pattern of the p- toluenesulfonate crystal form B of the compound of Formula I-1 is shown in Figure 27. Table 15 XRPD analysis data for the p-toluenesulfonate crystal form B of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing the p-toluenesulfonate crystal form B of the compound of Formula I-1, comprising adding the compound of Formula I-1 and p-toluenesulfonic acid to tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to p-toluenesulfonic acid is selected from the 0.8 to 1.2. The present invention also provides the methanesulfonate crystal form A of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.70±0.2∘<annotation encoding="application / x-tex">6.70 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.10±0.2∘<annotation encoding="application / x-tex">9.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.81±0.2∘<annotation encoding="application / x-tex">9.81 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.16±0.2∘<annotation encoding="application / x-tex">10.16 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.34±0.2∘<annotation encoding="application / x-tex">13.34 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.87±0.2∘<annotation encoding="application / x-tex">13.87 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.27±0.2∘<annotation encoding="application / x-tex">14.27 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.37±0.2∘<annotation encoding="application / x-tex">15.37 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.21±0.2∘<annotation encoding="application / x-tex">17.21 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.57±0.2∘<annotation encoding="application / x-tex">19.57 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.16±0.2∘<annotation encoding="application / x-tex">21.16 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.09±0.2∘<annotation encoding="application / x-tex">22.09 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.86±0.2∘<annotation encoding="application / x-tex">23.86 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.30±0.2∘<annotation encoding="application / x-tex">24.30 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.99±0.2∘<annotation encoding="application / x-tex">24.99 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.18±0.2∘<annotation encoding="application / x-tex">27.18 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the methanesulfonate crystal form A of the compound of Formula I-1 has characteristic diffraction peaks at the following 2θ angles: 6.70±0.2°, 9.10±0.2°, 9.81±0.2°, 10.16±0.2°, <com:Math><semantics>13.34±0.2∘<annotation encoding="application / x-tex">13.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.87±0.2∘<annotation encoding="application / x-tex">13.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.27±0.2∘<annotation encoding="application / x-tex">14.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.37±0.2∘<annotation encoding="application / x-tex">15.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.79±0.2∘<annotation encoding="application / x-tex">15.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.21±0.2∘<annotation encoding="application / x-tex">17.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.75±0.2∘<annotation encoding="application / x-tex">18.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.57±0.2∘<annotation encoding="application / x-tex">19.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.16±0.2∘<annotation encoding="application / x-tex">21.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.09±0.2∘<annotation encoding="application / x-tex">22.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.31±0.2∘<annotation encoding="application / x-tex">23.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.86±0.2∘<annotation encoding="application / x-tex">23.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.30±0.2∘<annotation encoding="application / x-tex">24.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.99±0.2∘<annotation encoding="application / x-tex">24.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.18±0.2∘<annotation encoding="application / x-tex">27.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.04±0.2∘<annotation encoding="application / x-tex">28.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.83±0.2∘<annotation encoding="application / x-tex">28.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the methanesulfonate crystal form A has an X-ray powder diffraction pattern substantially as shown in Figure 28. In some embodiments of the present invention, the XRPD pattern of methanesulfonate crystal form A of the compound of Formula I-1 is shown in Figure 28. Table 16 XRPD analysis data for the methanesulfonate crystal form A of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] The present invention also provides a method for preparing methanesulfonate crystal form A of the compound of Formula I-1, comprising adding the compound of Formula I-1 and methanesulfonic acid to tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to methanesulfonic acid is selected from 0.8 to 1.2. The present invention also provides the hydrochloride crystal form C1 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>7.47±0.2∘<annotation encoding="application / x-tex">7.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.73±0.2∘<annotation encoding="application / x-tex">7.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.25±0.2∘<annotation encoding="application / x-tex">12.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.18±0.2∘<annotation encoding="application / x-tex">13.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.51±0.2∘<annotation encoding="application / x-tex">13.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.96<annotation encoding="application / x-tex">14.96< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.46±0.2∘<annotation encoding="application / x-tex">15.46 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.31±0.2∘<annotation encoding="application / x-tex">17.31 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.56±0.2∘<annotation encoding="application / x-tex">18.56 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.34±0.2∘<annotation encoding="application / x-tex">19.34 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.57±0.2∘<annotation encoding="application / x-tex">19.57 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.78±0.2∘<annotation encoding="application / x-tex">19.78 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.01±0.2∘<annotation encoding="application / x-tex">20.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.76±0.2∘<annotation encoding="application / x-tex">20.76\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.36±0.2∘<annotation encoding="application / x-tex">24.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.63±0.2∘<annotation encoding="application / x-tex">25.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.47±0.2∘<annotation encoding="application / x-tex">26.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.51±0.2∘<annotation encoding="application / x-tex">27.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form C1 of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>7.47±0.2∘<annotation encoding="application / x-tex">7.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.73±0.2∘<annotation encoding="application / x-tex">7.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.63±0.2∘<annotation encoding="application / x-tex">9.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.46±0.2∘<annotation encoding="application / x-tex">11.46\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.25±0.2∘<annotation encoding="application / x-tex">12.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.18±0.2∘<annotation encoding="application / x-tex">13.18 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.51±0.2∘<annotation encoding="application / x-tex">13.51 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.96±0.2∘<annotation encoding="application / x-tex">14.96 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.46±0.2∘<annotation encoding="application / x-tex">15.46 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.79±0.2∘<annotation encoding="application / x-tex">16.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.04±0.2∘<annotation encoding="application / x-tex">17.04 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.31±0.2∘<annotation encoding="application / x-tex">17.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.72±0.2∘<annotation encoding="application / x-tex">17.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.56±0.2∘<annotation encoding="application / x-tex">18.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.34±0.2∘<annotation encoding="application / x-tex">19.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.57±0.2∘<annotation encoding="application / x-tex">19.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.78±0.2∘<annotation encoding="application / x-tex">19.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.01±0.2∘<annotation encoding="application / x-tex">20.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.76±0.2∘<annotation encoding="application / x-tex">20.76\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.60±0.2∘<annotation encoding="application / x-tex">22.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.09±0.2∘<annotation encoding="application / x-tex">23.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.80±0.2∘<annotation encoding="application / x-tex">23.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.36±0.2∘<annotation encoding="application / x-tex">24.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.63±0.2∘<annotation encoding="application / x-tex">25.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 26.47±0.2°, 27.51±0.2°, 29.09±0.2°, 30.76±0.2°, 31.99±0.2°, 36.24±0.2°. In another preferred embodiment, the hydrochloride crystal form C1 has an X-ray powder diffraction pattern substantially as shown in Figure 29. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form C1 of the compound of Formula I-1 is shown in Figure 29. Table 17 XRPD analysis data for the hydrochloride crystal form C1 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form C1 of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>39.76∘C±2∘C<annotation encoding="application / x-tex">39.76^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 153.80°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition begins above <com:Math><semantics>214.75∘C±2∘C<annotation encoding="application / x-tex">214.75^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form C1 has a differential scanning calorimetry pattern substantially as shown in Figure 30. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form C1 of the compound of Formula I-1 is shown in Figure 30. In some embodiments of the present invention, the hydrochloride crystal form C1 of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>26.03∘C±2∘C<annotation encoding="application / x-tex">26.03^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>100.00∘C±2∘C<annotation encoding="application / x-tex">100.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>150.00∘<annotation encoding="application / x-tex">150.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form C1 has a thermogravimetric analysis pattern substantially as shown in Figure 31. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form C1 of the compound of Formula I-1 is shown in Figure 31. The present invention also provides a method for preparing the hydrochloride crystal form C1 of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to ethyl acetate, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form C1 of the compound of Formula I-1 is an ethyl acetate solvate and hydrate crystal form, with an ethyl acetate content of 0.62 equivalents and a water content of 3.0 equivalents. In another preferred embodiment, the hydrochloride crystal form C1 is an ethyl acetate solvate and hydrate crystal form, wherein the ethyl acetate content is 0.1 to 1 equivalent and the water content is 1 to 5 equivalents. The present invention also provides the hydrochloride crystal form C2 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>7.56±0.2∘<annotation encoding="application / x-tex">7.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.79±0.2∘<annotation encoding="application / x-tex">7.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.32±0.2∘<annotation encoding="application / x-tex">12.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.21±0.2∘<annotation encoding="application / x-tex">13.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.63±0.2∘<annotation encoding="application / x-tex">13.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.10<annotation encoding="application / x-tex">15.10< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.56±0.2∘<annotation encoding="application / x-tex">15.56 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.58±0.2∘<annotation encoding="application / x-tex">18.58 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.36±0.2∘<annotation encoding="application / x-tex">19.36 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.66±0.2∘<annotation encoding="application / x-tex">19.66 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.82±0.2∘<annotation encoding="application / x-tex">19.82 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.91±0.2∘<annotation encoding="application / x-tex">20.91 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.35±0.2∘<annotation encoding="application / x-tex">24.35 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.56±0.2∘<annotation encoding="application / x-tex">26.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.74±0.2∘<annotation encoding="application / x-tex">30.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form C2 of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: 7.56±0.2°, 7.79±0.2°, 9.65±0.2°, 11.48±0.2°, <com:Math><semantics>12.32±0.2∘<annotation encoding="application / x-tex">12.32 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.21±0.2∘<annotation encoding="application / x-tex">13.21 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.63±0.2∘<annotation encoding="application / x-tex">13.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.10±0.2∘<annotation encoding="application / x-tex">15.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.56±0.2∘<annotation encoding="application / x-tex">15.56 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.86±0.2∘<annotation encoding="application / x-tex">16.86 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.16±0.2∘<annotation encoding="application / x-tex">17.16 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.41±0.2∘<annotation encoding="application / x-tex">17.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.77±0.2∘<annotation encoding="application / x-tex">17.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.58±0.2∘<annotation encoding="application / x-tex">18.58\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.36±0.2∘<annotation encoding="application / x-tex">19.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.66±0.2∘<annotation encoding="application / x-tex">19.66\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.82±0.2∘<annotation encoding="application / x-tex">19.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.32±0.2∘<annotation encoding="application / x-tex">20.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.91±0.2∘<annotation encoding="application / x-tex">20.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.71±0.2∘<annotation encoding="application / x-tex">22.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.21±0.2∘<annotation encoding="application / x-tex">23.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.80±0.2∘<annotation encoding="application / x-tex">23.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.35±0.2∘<annotation encoding="application / x-tex">24.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.71±0.2∘<annotation encoding="application / x-tex">25.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.56±0.2∘<annotation encoding="application / x-tex">26.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.53±0.2∘<annotation encoding="application / x-tex">27.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.80±0.2∘<annotation encoding="application / x-tex">27.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.20±0.2∘<annotation encoding="application / x-tex">28.20\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.15±0.2∘<annotation encoding="application / x-tex">29.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.74±0.2∘<annotation encoding="application / x-tex">30.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.06±0.2∘<annotation encoding="application / x-tex">32.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.30±0.2∘<annotation encoding="application / x-tex">36.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>38.22±0.2∘<annotation encoding="application / x-tex">38.22\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form C2 has an X-ray powder diffraction pattern substantially as shown in Figure 32. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form C2 of the compound of Formula I-1 is shown in Figure 32. Table 18 XRPD analysis data for the hydrochloride crystal form C2 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form C2 of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>33.27∘C±2∘C<annotation encoding="application / x-tex">33.27^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>155.72∘C±2∘C<annotation encoding="application / x-tex">155.72^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins above <com:Math><semantics>212.45∘C±2∘C<annotation encoding="application / x-tex">212.45^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form C2 has a differential scanning calorimetry pattern substantially as shown in Figure 33. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form C2 of the compound of Formula I-1 is shown in Figure 33. In some embodiments of the present invention, the hydrochloride crystal form C2 of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>28.19∘C±2∘C<annotation encoding="application / x-tex">28.19^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>115.00∘C±2∘C<annotation encoding="application / x-tex">115.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>150.00∘<annotation encoding="application / x-tex">150.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form C2 has a thermogravimetric analysis pattern substantially as shown in Figure 34. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form C2 of the compound of Formula I-1 is shown in Figure 34. The present invention also provides a method for preparing the hydrochloride crystal form C2 of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to 2-methyl-tetrahydrofuran, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form C2 of the compound of Formula I-1 is a 2-methyl tetrahydrofuran solvate and hydrate crystal form, with a 2-methyl tetrahydrofuran content of 0.21 equivalents and a water content of 2.8 equivalents. In another preferred embodiment, the hydrochloride crystal form C2 is a 2-methyl- tetrahydrofuran solvate and hydrate crystal form, wherein the 2-methyl-tetrahydrofuran content is 0.05 to 0.5 equivalents and the water content is 1 to 5 equivalents. The present invention also provides the hydrochloride crystal form D of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.60±0.2∘<annotation encoding="application / x-tex">6.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.79±0.2∘<annotation encoding="application / x-tex">7.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.84±0.2∘<annotation encoding="application / x-tex">9.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.31±0.2∘<annotation encoding="application / x-tex">13.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.23±0.2∘<annotation encoding="application / x-tex">15.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.93<annotation encoding="application / x-tex">15.93< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2<annotation encoding="application / x-tex">\pm 0^{.2}< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.09±0.2<annotation encoding="application / x-tex">20.09 \pm 0^{.2}< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.41±0.2<annotation encoding="application / x-tex">20.41 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.23±0.2<annotation encoding="application / x-tex">21.23 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.80±0.2<annotation encoding="application / x-tex">21.80 \pm 0.2< / annotation>< / semantics>< / com:Math>°. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form D of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.60±0.2∘<annotation encoding="application / x-tex">6.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.26±0.2∘<annotation encoding="application / x-tex">7.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.79±0.2∘<annotation encoding="application / x-tex">7.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.48±0.2∘<annotation encoding="application / x-tex">8.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.84±0.2∘<annotation encoding="application / x-tex">9.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.18±0.2∘<annotation encoding="application / x-tex">11.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.31±0.2∘<annotation encoding="application / x-tex">13.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.89±0.2∘<annotation encoding="application / x-tex">13.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.64±0.2∘<annotation encoding="application / x-tex">14.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.98±0.2∘<annotation encoding="application / x-tex">14.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.23±0.2∘<annotation encoding="application / x-tex">15.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.93±0.2∘<annotation encoding="application / x-tex">15.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.27±0.2∘<annotation encoding="application / x-tex">16.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.04±0.2∘<annotation encoding="application / x-tex">17.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.21±0.2∘<annotation encoding="application / x-tex">18.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.33±0.2∘<annotation encoding="application / x-tex">19.33\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.09±0.2∘<annotation encoding="application / x-tex">20.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.23±0.2∘<annotation encoding="application / x-tex">21.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.80±0.2∘<annotation encoding="application / x-tex">21.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.49±0.2∘<annotation encoding="application / x-tex">23.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.79±0.2∘<annotation encoding="application / x-tex">24.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.43±0.2∘<annotation encoding="application / x-tex">28.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form D has an X-ray powder diffraction pattern substantially as shown in Figure 35. In some embodiments of the present invention, the XRPD pattern of the hydrochloride crystal form D of the compound of Formula I-1 is shown in Figure 35. Table 19 XRPD analysis data for the hydrochloride crystal form D of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form D of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>55.20∘<annotation encoding="application / x-tex">55.20^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C and 164.37°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins above <com:Math><semantics>211.35∘C±2∘C<annotation encoding="application / x-tex">211.35^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form D has a differential scanning calorimetry pattern substantially as shown in Figure 36. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form D of the compound of Formula I-1 is shown in Figure 36. In some embodiments of the present invention, the hydrochloride crystal form D of the compound of Formula I-1 has two weight loss steps at <com:Math><semantics>36.24∘C±2∘C<annotation encoding="application / x-tex">36.24^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>110.00∘C±2∘C<annotation encoding="application / x-tex">110.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form D has a thermogravimetric analysis pattern substantially as shown in Figure 37. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form D of the compound of Formula I-1 is shown in Figure 37. The present invention also provides a method for preparing the hydrochloride crystal form D of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to butanone, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form D of the compound of Formula I-1 is an anhydrous crystal form. The present invention also provides the hydrochloride crystal form E1 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.15±0.2∘<annotation encoding="application / x-tex">6.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.66±0.2∘<annotation encoding="application / x-tex">7.66\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.90±0.2∘<annotation encoding="application / x-tex">7.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.06±0.2∘<annotation encoding="application / x-tex">13.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.06±0.2∘<annotation encoding="application / x-tex">14.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.25±0.2<annotation encoding="application / x-tex">16.25 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>18.37±0.2<annotation encoding="application / x-tex">18.37 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>19.01±0.2<annotation encoding="application / x-tex">19.01 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>19.75±0.2<annotation encoding="application / x-tex">19.75 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.19±0.2<annotation encoding="application / x-tex">20.19 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>23.56±0.2<annotation encoding="application / x-tex">23.56 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.81±0.2<annotation encoding="application / x-tex">21.81 \pm 0.2< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.95±0.2∘<annotation encoding="application / x-tex">24.95 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.18±0.2∘<annotation encoding="application / x-tex">25.18 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.63±0.2∘<annotation encoding="application / x-tex">25.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.71±0.2∘<annotation encoding="application / x-tex">26.71 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.10±0.2∘<annotation encoding="application / x-tex">27.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.91±0.2∘<annotation encoding="application / x-tex">27.91 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.81±0.2∘<annotation encoding="application / x-tex">29.81 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.93±0.2∘<annotation encoding="application / x-tex">32.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form E1 of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.15±0.2∘<annotation encoding="application / x-tex">6.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.66±0.2∘<annotation encoding="application / x-tex">7.66\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.90±0.2∘<annotation encoding="application / x-tex">7.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.41±0.2∘<annotation encoding="application / x-tex">8.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.49±0.2∘<annotation encoding="application / x-tex">9.49 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.91±0.2∘<annotation encoding="application / x-tex">9.91 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.88±0.2∘<annotation encoding="application / x-tex">10.88 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.42±0.2∘<annotation encoding="application / x-tex">11.42 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.06±0.2∘<annotation encoding="application / x-tex">13.06 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.66±0.2∘<annotation encoding="application / x-tex">13.66 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.06±0.2∘<annotation encoding="application / x-tex">14.06 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.69±0.2∘<annotation encoding="application / x-tex">14.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.32±0.2∘<annotation encoding="application / x-tex">15.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.52±0.2∘<annotation encoding="application / x-tex">15.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.88±0.2∘<annotation encoding="application / x-tex">15.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.25±0.2∘<annotation encoding="application / x-tex">16.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.81±0.2∘<annotation encoding="application / x-tex">16.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.35±0.2∘<annotation encoding="application / x-tex">17.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.37±0.2∘<annotation encoding="application / x-tex">18.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.01±0.2∘<annotation encoding="application / x-tex">19.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.75±0.2∘<annotation encoding="application / x-tex">19.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.19±0.2∘<annotation encoding="application / x-tex">20.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.15±0.2∘<annotation encoding="application / x-tex">21.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.51±0.2∘<annotation encoding="application / x-tex">21.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.81±0.2∘<annotation encoding="application / x-tex">21.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.50±0.2∘<annotation encoding="application / x-tex">22.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.87±0.2∘<annotation encoding="application / x-tex">22.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.56±0.2∘<annotation encoding="application / x-tex">23.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.95±0.2∘<annotation encoding="application / x-tex">24.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.18±0.2∘<annotation encoding="application / x-tex">25.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.63±0.2∘<annotation encoding="application / x-tex">25.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.71±0.2∘<annotation encoding="application / x-tex">26.71\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.10±0.2∘<annotation encoding="application / x-tex">27.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.91±0.2∘<annotation encoding="application / x-tex">27.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.47±0.2∘<annotation encoding="application / x-tex">28.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.30±0.2∘<annotation encoding="application / x-tex">29.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.81±0.2∘<annotation encoding="application / x-tex">29.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.12±0.2∘<annotation encoding="application / x-tex">30.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.93±0.2∘<annotation encoding="application / x-tex">32.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.96±0.2∘<annotation encoding="application / x-tex">34.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form E1 has an X-ray powder diffraction pattern substantially as shown in Figure 38. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form E1 of the compound of Formula I-1 is shown in Figure 38. Table 20 XRPD analysis data for the hydrochloride crystal form E1 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form E1 of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>13.36∘C±2∘C<annotation encoding="application / x-tex">13.36^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 174.06°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>211.29∘C±2∘C<annotation encoding="application / x-tex">211.29^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form E1 has a differential scanning calorimetry pattern substantially as shown in Figure 39. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form E1 of the compound of Formula I-1 is shown in Figure 39. In some embodiments of the present invention, the hydrochloride crystal form E1 of the compound of Formula I-1 has three weight loss steps at 25.81°C ± 2°C, 120.00°C ± 2°C, and <com:Math><semantics>160.00∘<annotation encoding="application / x-tex">160.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form E1 has a thermogravimetric analysis pattern substantially as shown in Figure 40. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form E1 of the compound of Formula I-1 is shown in Figure 40. The present invention also provides a method for preparing the hydrochloride crystal form E1 of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to ethanol, and then performing recrystallization or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form E1 of the compound of Formula I-1 is a hydrate crystal form with a water content of 1.7 equivalents. In another preferred embodiment, the hydrochloride crystal form E1 of the compound of formula (I) is a hydrate crystal form, wherein the water content is 0.5 to 4 equivalents. The present invention also provides the hydrochloride crystal form E2 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>7.88±0.2∘<annotation encoding="application / x-tex">7.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.90±0.2∘<annotation encoding="application / x-tex">10.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.10±0.2∘<annotation encoding="application / x-tex">13.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.14±0.2∘<annotation encoding="application / x-tex">14.14\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.30±0.2∘<annotation encoding="application / x-tex">16.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.01±0.2∘<annotation encoding="application / x-tex">19.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.75±0.2∘<annotation encoding="application / x-tex">19.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.54±0.2∘<annotation encoding="application / x-tex">21.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.84±0.2∘<annotation encoding="application / x-tex">21.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.63±0.2∘<annotation encoding="application / x-tex">23.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.96±0.2∘<annotation encoding="application / x-tex">24.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.78±0.2∘<annotation encoding="application / x-tex">26.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 29.91±0.2°. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form E2 of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>7.88±0.2∘<annotation encoding="application / x-tex">7.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.51±0.2∘<annotation encoding="application / x-tex">9.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.90±0.2∘<annotation encoding="application / x-tex">10.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.49±0.2∘<annotation encoding="application / x-tex">11.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.10±0.2∘<annotation encoding="application / x-tex">13.10 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.64±0.2∘<annotation encoding="application / x-tex">13.64 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.14±0.2∘<annotation encoding="application / x-tex">14.14 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.76±0.2∘<annotation encoding="application / x-tex">14.76 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.39±0.2∘<annotation encoding="application / x-tex">15.39 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.75±0.2∘<annotation encoding="application / x-tex">15.75 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.30±0.2∘<annotation encoding="application / x-tex">16.30 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.93±0.2∘<annotation encoding="application / x-tex">16.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.01±0.2∘<annotation encoding="application / x-tex">19.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.75±0.2∘<annotation encoding="application / x-tex">19.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.69±0.2∘<annotation encoding="application / x-tex">20.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.54±0.2∘<annotation encoding="application / x-tex">21.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.84±0.2∘<annotation encoding="application / x-tex">21.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.19±0.2∘<annotation encoding="application / x-tex">22.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.57±0.2∘<annotation encoding="application / x-tex">22.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.01±0.2∘<annotation encoding="application / x-tex">23.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.63±0.2∘<annotation encoding="application / x-tex">23.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.96±0.2∘<annotation encoding="application / x-tex">24.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.90±0.2∘<annotation encoding="application / x-tex">25.90\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.32±0.2∘<annotation encoding="application / x-tex">26.32\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.78±0.2∘<annotation encoding="application / x-tex">26.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.19±0.2∘<annotation encoding="application / x-tex">27.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.48±0.2∘<annotation encoding="application / x-tex">27.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.94±0.2∘<annotation encoding="application / x-tex">27.94\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.68±0.2∘<annotation encoding="application / x-tex">28.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.07±0.2∘<annotation encoding="application / x-tex">29.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.50±0.2∘<annotation encoding="application / x-tex">29.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.91±0.2∘<annotation encoding="application / x-tex">29.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.74±0.2∘<annotation encoding="application / x-tex">31.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.96±0.2∘<annotation encoding="application / x-tex">32.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.66±0.2∘<annotation encoding="application / x-tex">33.66\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form E2 has an X-ray powder diffraction pattern substantially as shown in Figure 41. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form E2 of the compound of Formula I-1 is shown in Figure 41. Table 21 XRPD analysis data for the hydrochloride crystal form E2 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form E2 of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>14.99∘C±2∘C<annotation encoding="application / x-tex">14.99^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 174.19°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>213.17∘C±2∘C<annotation encoding="application / x-tex">213.17^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form E2 has a differential scanning calorimetry pattern substantially as shown in Figure 42. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form E2 of the compound of Formula I-1 is shown in Figure 42. In some embodiments of the present invention, the hydrochloride crystal form E2 of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>33.18∘C±2∘C<annotation encoding="application / x-tex">33.18^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>90.00∘C±2∘C<annotation encoding="application / x-tex">90.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>140.00∘<annotation encoding="application / x-tex">140.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form E2 has a thermogravimetric analysis pattern substantially as shown in Figure 43. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form E2 of the compound of Formula I-1 is shown in Figure 43. The present invention also provides a method for preparing the hydrochloride crystal form E2 of the compound of Formula I-1, comprising drying the hydrochloride crystal form F of the compound of Formula I-1 under vacuum at 25°C, 50°C, or 100°C, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form E2 of the compound of Formula I-1 is a hydrate crystal form with a water content of 1.8 equivalents. In another preferred embodiment, the hydrochloride crystal form E2 of the compound of formula (I) is prepared by subjecting the hydrochloride crystal form F of the compound of formula (I) to vacuum at 10°C to 70°C. In another preferred embodiment, the hydrochloride crystal form E2 of the compound of formula (I) is prepared by drying the hydrochloride crystal form F of the compound of formula (I) at 80°C to 120°C. In another preferred embodiment, the hydrochloride crystal form E2 of the compound of formula (I) is a hydrate crystal form, wherein the water content is 0.5 to 4 equivalents. The present invention also provides the hydrochloride crystal form F of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>7.65±0.2∘<annotation encoding="application / x-tex">7.65 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.47±0.2∘<annotation encoding="application / x-tex">11.47 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.93±0.2∘<annotation encoding="application / x-tex">13.93 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.80±0.2∘<annotation encoding="application / x-tex">14.80 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.25±0.2∘<annotation encoding="application / x-tex">15.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.84±0.2<annotation encoding="application / x-tex">19.84 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>20.09±0.2<annotation encoding="application / x-tex">20.09 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>21.51±0.2<annotation encoding="application / x-tex">21.51 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>23.22±0.2<annotation encoding="application / x-tex">23.22 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>25.06±0.2<annotation encoding="application / x-tex">25.06 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>26.68±0.2<annotation encoding="application / x-tex">26.68 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math>°, <com:Math><semantics>28.87±0.2<annotation encoding="application / x-tex">28.87 \pm 0.2< / annotation>< / semantics>< / com:Math> <com:Math><semantics>0.2∘<annotation encoding="application / x-tex">0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.45±0.2∘<annotation encoding="application / x-tex">32.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.59±0.2∘<annotation encoding="application / x-tex">33.59 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form F of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.85±0.2∘<annotation encoding="application / x-tex">6.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.65±0.2∘<annotation encoding="application / x-tex">7.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.21±0.2∘<annotation encoding="application / x-tex">10.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.70±0.2∘<annotation encoding="application / x-tex">10.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.47±0.2∘<annotation encoding="application / x-tex">11.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.93±0.2∘<annotation encoding="application / x-tex">13.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.80±0.2∘<annotation encoding="application / x-tex">14.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.25±0.2∘<annotation encoding="application / x-tex">15.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.60±0.2∘<annotation encoding="application / x-tex">16.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.88±0.2∘<annotation encoding="application / x-tex">16.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.84±0.2∘<annotation encoding="application / x-tex">17.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.00±0.2∘<annotation encoding="application / x-tex">19.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.16±0.2∘<annotation encoding="application / x-tex">19.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.84±0.2∘<annotation encoding="application / x-tex">19.84\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.09±0.2∘<annotation encoding="application / x-tex">20.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.34±0.2∘<annotation encoding="application / x-tex">20.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.51±0.2∘<annotation encoding="application / x-tex">21.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.35±0.2∘<annotation encoding="application / x-tex">22.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.22±0.2∘<annotation encoding="application / x-tex">23.22\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.86±0.2∘<annotation encoding="application / x-tex">23.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.06±0.2∘<annotation encoding="application / x-tex">25.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.31±0.2∘<annotation encoding="application / x-tex">25.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.63±0.2∘<annotation encoding="application / x-tex">25.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.68±0.2∘<annotation encoding="application / x-tex">26.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.10±0.2∘<annotation encoding="application / x-tex">28.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.87±0.2∘<annotation encoding="application / x-tex">28.87\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.53±0.2∘<annotation encoding="application / x-tex">30.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.45±0.2∘<annotation encoding="application / x-tex">32.45\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.59±0.2∘<annotation encoding="application / x-tex">33.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form F has an X-ray powder diffraction pattern substantially as shown in Figure 44. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the hydrochloride crystal form F of the compound of Formula I-1 is shown in Figure 44. Table 22 XRPD analysis data for the hydrochloride crystal form F of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form F of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>36.03∘C±2∘C<annotation encoding="application / x-tex">36.03^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 172.45°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>212.66∘C±2∘C<annotation encoding="application / x-tex">212.66^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form F has a differential scanning calorimetry pattern substantially as shown in Figure 45. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form F of the compound of Formula I-1 is shown in Figure 45. In some embodiments of the present invention, the hydrochloride crystal form F of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>33.35∘C±2∘C<annotation encoding="application / x-tex">33.35^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>100.00∘C±2∘C<annotation encoding="application / x-tex">100.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>150.00∘<annotation encoding="application / x-tex">150.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form F has a thermogravimetric analysis pattern substantially as shown in Figure 46. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form F of the compound of Formula I-1 is shown in Figure 46. The present invention also provides a method for preparing the hydrochloride crystal form F of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to ethanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, or a mixed solvent of methyl isobutyl ketone / trifluoroethanol, and then performing recrystallization at 50°C or slurrying to obtain it, the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form F of the compound of Formula I-1 is a hydrate crystal form with a water content of 2.0 equivalents. In another preferred embodiment, the hydrochloride crystal form F of the compound of formula (I) is a hydrate crystal form, wherein the water content is 1 to 4 equivalents. The present invention also provides the hydrochloride crystal form G of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>5.83±0.2∘<annotation encoding="application / x-tex">5.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.97±0.2∘<annotation encoding="application / x-tex">9.97\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.26±0.2∘<annotation encoding="application / x-tex">13.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.17±0.2∘<annotation encoding="application / x-tex">14.17\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.52±0.2∘<annotation encoding="application / x-tex">15.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.77±0.2∘<annotation encoding="application / x-tex">16.77\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.37±0.2∘<annotation encoding="application / x-tex">18.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.27±0.2∘<annotation encoding="application / x-tex">20.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.48±0.2∘<annotation encoding="application / x-tex">20.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.35±0.2∘<annotation encoding="application / x-tex">21.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.82±0.2∘<annotation encoding="application / x-tex">21.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.65±0.2∘<annotation encoding="application / x-tex">22.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.04±0.2∘<annotation encoding="application / x-tex">23.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.43±0.2∘<annotation encoding="application / x-tex">24.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.24±0.2∘<annotation encoding="application / x-tex">26.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.54±0.2∘<annotation encoding="application / x-tex">26.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.94±0.2∘<annotation encoding="application / x-tex">28.94\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.18±0.2∘<annotation encoding="application / x-tex">30.18\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form G of the compound of Formula I-1 has characteristic diffraction peaks at the following 2θ angles: 5.83±0.2°, 7.18±0.2°, 9.97±0.2°, 11.63±0.2°, 12.00±0.2°, <Formule mathématique disponible dans le document PDF, Math available in the PDF document>$12.35\pm0.2^{\circ}, \quad 13.26\pm0.2^{\circ}, \quad 13.58\pm0.2^{\circ}, \quad 14.17\pm0.2^{\circ}, \quad 14.60\pm0.2^{\circ}, \quad 15.52\pm0.2^{\circ}, \quad 16.77\pm0.2^{\circ}, \\ 17.64\pm0.2^{\circ}, \quad 18.37\pm0.2^{\circ}, \quad 18.81\pm0.2^{\circ}, \quad 19.14\pm0.2^{\circ}, \quad 19.80\pm0.2^{\circ}, \quad 20.27\pm0.2^{\circ}, \quad$ <com:Math><semantics>21.35±0.2∘<annotation encoding="application / x-tex">21.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.82±0.2∘<annotation encoding="application / x-tex">21.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.65±0.2∘<annotation encoding="application / x-tex">22.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.04±0.2∘<annotation encoding="application / x-tex">23.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.35±0.2∘<annotation encoding="application / x-tex">23.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.43±0.2∘<annotation encoding="application / x-tex">24.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.47±0.2∘<annotation encoding="application / x-tex">25.47\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 26.24±0.2°, 26.54±0.2°, 26.84±0.2°, 27.92±0.2°, 28.94±0.2°, 29.31±0.2°, 30.18±0.2°. In another preferred embodiment, the hydrochloride crystal form G has an X-ray powder diffraction pattern substantially as shown in Figure 47. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the hydrochloride crystal form G of the compound of Formula I-1 is shown in Figure 47. Table 23 XRPD analysis data for the hydrochloride crystal form G of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form G of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>59.42∘C±2∘C<annotation encoding="application / x-tex">59.42^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>151.02∘C<annotation encoding="application / x-tex">151.02^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±<annotation encoding="application / x-tex">\pm< / annotation>< / semantics>< / com:Math> 2°C, and 166.01°C <com:Math><semantics>±<annotation encoding="application / x-tex">\pm< / annotation>< / semantics>< / com:Math> 2°C in its differential scanning calorimetry (DSC) curve. In another preferred embodiment, the hydrochloride crystal form G has a differential scanning calorimetry pattern substantially as shown in Figure 48. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form G of the compound of Formula I-1 is shown in Figure 48. In some embodiments of the present invention, the hydrochloride crystal form G of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>26.28∘<annotation encoding="application / x-tex">26.28^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C, <com:Math><semantics>120.00∘<annotation encoding="application / x-tex">120.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C, and <com:Math><semantics>150.00∘C±2∘C<annotation encoding="application / x-tex">150.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form G has a thermogravimetric analysis pattern substantially as shown in Figure 49. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form G of the compound of Formula I-1 is shown in Figure 49. The present invention also provides a method for preparing the hydrochloride crystal form G of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to water, and then performing suspension recrystallization at 25°C, 50°C, or under heating-cooling cycles or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form G of the compound of Formula I-1 is a hydrate crystal form with a water content of 3.0 equivalents. In another preferred embodiment, the hydrochloride crystal form G of the compound of formula (I) is a hydrate crystal form, wherein the water content is 1.0 to 6 equivalents. The present invention also provides the hydrochloride crystal form H of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>5.83±0.2∘<annotation encoding="application / x-tex">5.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.16±0.2∘<annotation encoding="application / x-tex">7.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.02±0.2∘<annotation encoding="application / x-tex">10.02\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.64±0.2∘<annotation encoding="application / x-tex">11.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.23±0.2∘<annotation encoding="application / x-tex">13.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.58<annotation encoding="application / x-tex">14.58< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.67±0.2∘<annotation encoding="application / x-tex">16.67 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.40±0.2∘<annotation encoding="application / x-tex">18.40 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.62±0.2∘<annotation encoding="application / x-tex">18.62 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.23±0.2∘<annotation encoding="application / x-tex">20.23 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.54±0.2∘<annotation encoding="application / x-tex">20.54 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.40±0.2∘<annotation encoding="application / x-tex">21.40 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.62±0.2∘<annotation encoding="application / x-tex">22.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.78±0.2∘<annotation encoding="application / x-tex">22.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.36±0.2∘<annotation encoding="application / x-tex">23.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.73±0.2∘<annotation encoding="application / x-tex">24.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.23±0.2∘<annotation encoding="application / x-tex">26.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.57±0.2∘<annotation encoding="application / x-tex">26.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.91±0.2∘<annotation encoding="application / x-tex">26.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.30±0.2∘<annotation encoding="application / x-tex">29.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.21±0.2∘<annotation encoding="application / x-tex">30.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form H of the compound of Formula I-1 has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>5.83±0.2∘<annotation encoding="application / x-tex">5.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.16±0.2∘<annotation encoding="application / x-tex">7.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.02±0.2∘<annotation encoding="application / x-tex">10.02\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.64±0.2∘<annotation encoding="application / x-tex">11.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.35±0.2∘<annotation encoding="application / x-tex">12.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.23±0.2∘<annotation encoding="application / x-tex">13.23 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.59±0.2∘<annotation encoding="application / x-tex">13.59 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.58±0.2∘<annotation encoding="application / x-tex">14.58 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.51±0.2∘<annotation encoding="application / x-tex">15.51 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.97±0.2∘<annotation encoding="application / x-tex">15.97 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.67±0.2∘<annotation encoding="application / x-tex">16.67 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.63±0.2∘<annotation encoding="application / x-tex">17.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.40±0.2∘<annotation encoding="application / x-tex">18.40\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.62±0.2∘<annotation encoding="application / x-tex">18.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.11±0.2∘<annotation encoding="application / x-tex">19.11\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.23±0.2∘<annotation encoding="application / x-tex">20.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.54±0.2∘<annotation encoding="application / x-tex">20.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.40±0.2∘<annotation encoding="application / x-tex">21.40\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.07±0.2∘<annotation encoding="application / x-tex">22.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.62±0.2∘<annotation encoding="application / x-tex">22.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.78±0.2∘<annotation encoding="application / x-tex">22.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.36±0.2∘<annotation encoding="application / x-tex">23.36\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.73±0.2∘<annotation encoding="application / x-tex">24.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.98±0.2∘<annotation encoding="application / x-tex">24.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.23±0.2∘<annotation encoding="application / x-tex">26.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.57±0.2∘<annotation encoding="application / x-tex">26.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.91±0.2∘<annotation encoding="application / x-tex">26.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.88±0.2∘<annotation encoding="application / x-tex">27.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.01±0.2∘<annotation encoding="application / x-tex">29.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.30±0.2∘<annotation encoding="application / x-tex">29.30\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.61±0.2∘<annotation encoding="application / x-tex">29.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.21±0.2∘<annotation encoding="application / x-tex">30.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.21±0.2∘<annotation encoding="application / x-tex">31.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.12±0.2∘<annotation encoding="application / x-tex">32.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.66±0.2∘<annotation encoding="application / x-tex">34.66\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form H has an X-ray powder diffraction pattern substantially as shown in Figure 50. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the hydrochloride crystal form H of the compound of Formula I-1 is shown in Figure 50. Table 24 XRPD analysis data for the hydrochloride crystal form H of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form H of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>51.49∘C±2∘C<annotation encoding="application / x-tex">51.49^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 153.61°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>211.73∘C±2∘C<annotation encoding="application / x-tex">211.73^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form H has a differential scanning calorimetry pattern substantially as shown in Figure 51. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form H of the compound of Formula I-1 is shown in Figure 51 In some embodiments of the present invention, the hydrochloride crystal form H of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>26.12∘C±2∘C<annotation encoding="application / x-tex">26.12^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>110.00∘C±2∘C<annotation encoding="application / x-tex">110.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>150.00∘<annotation encoding="application / x-tex">150.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form H has a thermogravimetric analysis pattern substantially as shown in Figure 52. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form H of the compound of Formula I-1 is shown in Figure 52. The present invention also provides a method for preparing the hydrochloride crystal form H of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to a methanol / water mixed solvent, and then performing suspension recrystallization at 25°C or 50°C or slurrying to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form H of the compound of Formula I-1 is a hydrate crystal form, with a water content of 3.9 equivalents. In another preferred embodiment, the hydrochloride crystal form H of the compound of formula (I) is a hydrate crystal form, wherein the water content is 2 to 8 equivalents. The present invention also provides the hydrochloride crystal form I of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.68±0.2∘<annotation encoding="application / x-tex">6.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.31±0.2∘<annotation encoding="application / x-tex">12.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.54±0.2∘<annotation encoding="application / x-tex">12.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.34±0.2∘<annotation encoding="application / x-tex">13.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.05±0.2∘<annotation encoding="application / x-tex">14.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.96<annotation encoding="application / x-tex">14.96< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.92±0.2∘<annotation encoding="application / x-tex">17.92 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.03±0.2∘<annotation encoding="application / x-tex">19.03 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.74±0.2∘<annotation encoding="application / x-tex">19.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.99±0.2∘<annotation encoding="application / x-tex">19.99 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.96±0.2∘<annotation encoding="application / x-tex">20.96 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.42±0.2∘<annotation encoding="application / x-tex">21.42 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.62<annotation encoding="application / x-tex">21.62< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.81±0.2∘<annotation encoding="application / x-tex">26.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.21±0.2∘<annotation encoding="application / x-tex">27.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.60±0.2∘<annotation encoding="application / x-tex">27.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.78±0.2∘<annotation encoding="application / x-tex">27.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.07±0.2∘<annotation encoding="application / x-tex">30.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.00±0.2∘<annotation encoding="application / x-tex">31.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.83±0.2∘<annotation encoding="application / x-tex">34.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form I of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.68±0.2∘<annotation encoding="application / x-tex">6.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>9.50±0.2∘<annotation encoding="application / x-tex">9.50\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.31±0.2∘<annotation encoding="application / x-tex">12.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.54±0.2∘<annotation encoding="application / x-tex">12.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.34±0.2∘<annotation encoding="application / x-tex">13.34\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.05±0.2∘<annotation encoding="application / x-tex">14.05 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.96±0.2∘<annotation encoding="application / x-tex">14.96 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.38±0.2∘<annotation encoding="application / x-tex">15.38 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.18±0.2∘<annotation encoding="application / x-tex">17.18 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.92±0.2∘<annotation encoding="application / x-tex">17.92 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.03±0.2∘<annotation encoding="application / x-tex">19.03 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.74±0.2∘<annotation encoding="application / x-tex">19.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.99±0.2∘<annotation encoding="application / x-tex">19.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.96±0.2∘<annotation encoding="application / x-tex">20.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.42±0.2∘<annotation encoding="application / x-tex">21.42\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.62±0.2∘<annotation encoding="application / x-tex">21.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.99±0.2∘<annotation encoding="application / x-tex">21.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.98±0.2∘<annotation encoding="application / x-tex">22.98\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.52±0.2∘<annotation encoding="application / x-tex">23.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.80±0.2∘<annotation encoding="application / x-tex">23.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.38±0.2∘<annotation encoding="application / x-tex">24.38\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.92±0.2∘<annotation encoding="application / x-tex">25.92\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.81±0.2∘<annotation encoding="application / x-tex">26.81\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.21±0.2∘<annotation encoding="application / x-tex">27.21\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.60±0.2∘<annotation encoding="application / x-tex">27.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.78±0.2∘<annotation encoding="application / x-tex">27.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.26±0.2∘<annotation encoding="application / x-tex">28.26\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.74±0.2∘<annotation encoding="application / x-tex">28.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.07±0.2∘<annotation encoding="application / x-tex">30.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.00±0.2∘<annotation encoding="application / x-tex">31.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.69±0.2∘<annotation encoding="application / x-tex">32.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.02±0.2∘<annotation encoding="application / x-tex">34.02\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>34.83±0.2∘<annotation encoding="application / x-tex">34.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form I has an X-ray powder diffraction pattern substantially as shown in Figure 53. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form I of the compound of Formula I-1 is shown in Figure 53. Table 25 XRPD analysis data for the hydrochloride crystal form I of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form I of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>18.15∘C±2∘C<annotation encoding="application / x-tex">18.15^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 194.49°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>215.51∘C±2∘C<annotation encoding="application / x-tex">215.51^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> In another preferred embodiment, the hydrochloride crystal form I has a differential scanning calorimetry pattern substantially as shown in Figure 54. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form I of the compound of Formula I-1 is shown in Figure 54. In some embodiments of the present invention, the hydrochloride crystal form I of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>28.31∘C±2∘C<annotation encoding="application / x-tex">28.31^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>70.00∘C±2∘C<annotation encoding="application / x-tex">70.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>173.00∘<annotation encoding="application / x-tex">173.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form I has a thermogravimetric analysis pattern substantially as shown in Figure 55. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form I of the compound of Formula I-1 is shown in Figure 55. The present invention also provides a method for preparing the hydrochloride crystal form I of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to methanol or a methanol / tert-butyl methyl ether mixed solvent, and then performing suspension recrystallization in a tert-butyl methyl ether or slurrying to obtain it, the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form I of the compound of Formula I-1 is an anhydrous crystal form. In another preferred embodiment, the hydrochloride crystal form I of the compound of formula (I) is an anhydrous crystal form. The present invention also provides the hydrochloride crystal form J1 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.80±0.2∘<annotation encoding="application / x-tex">6.80 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.69±0.2∘<annotation encoding="application / x-tex">11.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.87±0.2∘<annotation encoding="application / x-tex">14.87 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.98±0.2∘<annotation encoding="application / x-tex">15.98 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.05±0.2∘<annotation encoding="application / x-tex">18.05 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.49±0.2∘<annotation encoding="application / x-tex">19.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.55±0.2∘<annotation encoding="application / x-tex">21.55\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.70±0.2∘<annotation encoding="application / x-tex">21.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.06±0.2∘<annotation encoding="application / x-tex">22.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.69±0.2∘<annotation encoding="application / x-tex">23.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.92±0.2∘<annotation encoding="application / x-tex">24.92\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.13±0.2∘<annotation encoding="application / x-tex">25.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.07±0.2∘<annotation encoding="application / x-tex">29.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.16±0.2∘<annotation encoding="application / x-tex">30.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form J1 of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.80±0.2∘<annotation encoding="application / x-tex">6.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.82±0.2∘<annotation encoding="application / x-tex">7.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.95±0.2∘<annotation encoding="application / x-tex">7.95\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.08±0.2∘<annotation encoding="application / x-tex">10.08\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.69±0.2∘<annotation encoding="application / x-tex">11.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.30±0.2∘<annotation encoding="application / x-tex">12.30 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.60±0.2∘<annotation encoding="application / x-tex">12.60 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.60±0.2∘<annotation encoding="application / x-tex">13.60 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.87±0.2∘<annotation encoding="application / x-tex">14.87 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.98±0.2∘<annotation encoding="application / x-tex">15.98 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.25±0.2∘<annotation encoding="application / x-tex">16.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.05±0.2∘<annotation encoding="application / x-tex">18.05\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.60±0.2∘<annotation encoding="application / x-tex">18.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.79±0.2∘<annotation encoding="application / x-tex">18.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.49±0.2∘<annotation encoding="application / x-tex">19.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.41±0.2∘<annotation encoding="application / x-tex">20.41\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.82±0.2∘<annotation encoding="application / x-tex">20.82\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.55±0.2∘<annotation encoding="application / x-tex">21.55\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.70±0.2∘<annotation encoding="application / x-tex">21.70\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.06±0.2∘<annotation encoding="application / x-tex">22.06\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.88±0.2∘<annotation encoding="application / x-tex">22.88\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.69±0.2∘<annotation encoding="application / x-tex">23.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.92±0.2∘<annotation encoding="application / x-tex">24.92\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.13±0.2∘<annotation encoding="application / x-tex">25.13\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.19±0.2∘<annotation encoding="application / x-tex">26.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.57±0.2∘<annotation encoding="application / x-tex">26.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.07±0.2∘<annotation encoding="application / x-tex">29.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.16±0.2∘<annotation encoding="application / x-tex">30.16\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>31.85±0.2∘<annotation encoding="application / x-tex">31.85\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.80±0.2∘<annotation encoding="application / x-tex">32.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form J1 has an X-ray powder diffraction pattern substantially as shown in Figure 56. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form J1 of the compound of Formula I-1 is shown in Figure 56. Table 26 XRPD analysis data for the hydrochloride crystal form J1 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form J1 of the compound of Formula I-1 has the onsets of the endothermic peaks at 70.82°C ± 2°C and 165.48°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>212.96∘C±2∘C<annotation encoding="application / x-tex">212.96^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form J1 has a differential scanning calorimetry pattern substantially as shown in Figure 57. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form J1 of the compound of Formula I-1 is shown in Figure 57. In some embodiments of the present invention, the hydrochloride crystal form J1 of the compound of Formula I-1 has two weight loss steps at <com:Math><semantics>33.94∘C±2∘C<annotation encoding="application / x-tex">33.94^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> and <com:Math><semantics>110.00∘C±2∘C<annotation encoding="application / x-tex">110.00^{\circ}\text{C} \pm 2^{\circ}\text{C}< / annotation>< / semantics>< / com:Math> in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form J1 has a thermogravimetric analysis pattern substantially as shown in Figure 58. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form J1 of the compound of Formula I-1 is shown in Figure 58. The present invention also provides a method for preparing the hydrochloride crystal form J1 of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to 2-methyl-tetrahydrofuran, and then performing suspension recrystallization at 50°C or under heating-cooling cycles or slurrying to obtain it, the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form J1 of the compound of Formula I-1 is a solvate of 2-methyl tetrahydrofuran and water, with a 2-methyl tetrahydrofuran content of 0.75 equivalents and a water content of 0.98 equivalents. In another preferred embodiment, the hydrochloride crystal form J1 of the compound of formula (I) is a solvate of 2-methyl-tetrahydrofuran and water, wherein the content of 2- methyl-tetrahydrofuran is 0.1 to 2 equivalents and the content of water is 0.1 to 2 equivalents. The present invention also provides the hydrochloride crystal form J2 of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.78±0.2∘<annotation encoding="application / x-tex">6.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.24±0.2∘<annotation encoding="application / x-tex">12.24\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.56±0.2∘<annotation encoding="application / x-tex">13.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.69±0.2∘<annotation encoding="application / x-tex">14.69\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.45±0.2∘<annotation encoding="application / x-tex">17.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.12±0.2∘<annotation encoding="application / x-tex">18.12 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.89±0.2∘<annotation encoding="application / x-tex">18.89 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.51±0.2∘<annotation encoding="application / x-tex">19.51 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.28±0.2∘<annotation encoding="application / x-tex">21.28 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.46±0.2∘<annotation encoding="application / x-tex">21.46 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.23±0.2∘<annotation encoding="application / x-tex">22.23 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.09±0.2∘<annotation encoding="application / x-tex">24.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.86±0.2∘<annotation encoding="application / x-tex">24.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.99±0.2∘<annotation encoding="application / x-tex">24.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.00±0.2∘<annotation encoding="application / x-tex">29.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form J2 of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.78±0.2∘<annotation encoding="application / x-tex">6.78\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.96±0.2∘<annotation encoding="application / x-tex">7.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.31±0.2∘<annotation encoding="application / x-tex">8.31\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.59±0.2∘<annotation encoding="application / x-tex">11.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.24±0.2∘<annotation encoding="application / x-tex">12.24 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.56±0.2∘<annotation encoding="application / x-tex">13.56 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.69±0.2∘<annotation encoding="application / x-tex">14.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.44±0.2∘<annotation encoding="application / x-tex">16.44 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.63±0.2∘<annotation encoding="application / x-tex">16.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.45±0.2∘<annotation encoding="application / x-tex">17.45 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.12±0.2∘<annotation encoding="application / x-tex">18.12 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.89±0.2∘<annotation encoding="application / x-tex">18.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.51±0.2∘<annotation encoding="application / x-tex">19.51\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.12±0.2∘<annotation encoding="application / x-tex">20.12\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.35±0.2∘<annotation encoding="application / x-tex">20.35\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.49±0.2∘<annotation encoding="application / x-tex">20.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.28±0.2∘<annotation encoding="application / x-tex">21.28\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.46±0.2∘<annotation encoding="application / x-tex">21.46\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.23±0.2∘<annotation encoding="application / x-tex">22.23\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.75±0.2∘<annotation encoding="application / x-tex">22.75\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.27±0.2∘<annotation encoding="application / x-tex">23.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.09±0.2∘<annotation encoding="application / x-tex">24.09\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.86±0.2∘<annotation encoding="application / x-tex">24.86\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.99±0.2∘<annotation encoding="application / x-tex">24.99\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.37±0.2∘<annotation encoding="application / x-tex">25.37\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.65±0.2∘<annotation encoding="application / x-tex">25.65\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.54±0.2∘<annotation encoding="application / x-tex">26.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.62±0.2∘<annotation encoding="application / x-tex">27.62\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>28.61±0.2∘<annotation encoding="application / x-tex">28.61\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.00±0.2∘<annotation encoding="application / x-tex">29.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>30.43±0.2∘<annotation encoding="application / x-tex">30.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.10±0.2∘<annotation encoding="application / x-tex">32.10\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>33.01±0.2∘<annotation encoding="application / x-tex">33.01\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>36.96±0.2∘<annotation encoding="application / x-tex">36.96\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form J2 has an X-ray powder diffraction pattern substantially as shown in Figure 59. In some embodiments of the present invention, the X-ray diffraction (XRPD) pattern of the hydrochloride crystal form J2 of the compound of Formula I-1 is shown in Figure 59. Table 27 XRPD analysis data for the hydrochloride crystal form J2 of the compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form J2 of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>77.60∘<annotation encoding="application / x-tex">77.60^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±<annotation encoding="application / x-tex">\pm< / annotation>< / semantics>< / com:Math> 2<com:Math><semantics>∘<annotation encoding="application / x-tex">^{\circ}< / annotation>< / semantics>< / com:Math>C and 163.47°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>211.78∘C±2∘C<annotation encoding="application / x-tex">211.78^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form J2 has a differential scanning calorimetry pattern substantially as shown in Figure 60. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form J2 of the compound of Formula I-1 is shown in Figure 60. In some embodiments of the present invention, the hydrochloride crystal form J2 of the compound of Formula I-1 has two weight loss steps at 28.73°C ± 2°C and 120.00°C ± 2°C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form J2 has a thermogravimetric analysis pattern substantially as shown in Figure 61. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form J2 of the compound of Formula I-1 is shown in Figure 61. The present invention also provides a method for preparing the hydrochloride crystal form J2 of the compound of Formula I-1, comprising heating the hydrochloride crystal form J1 of the compound of Formula I-1 to 110°C to obtain it, wherein the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, the hydrochloride crystal form J2 of the compound of Formula I-1 is a solvate of 2-methyl-tetrahydrofuran and water, with a 2-methyl-tetrahydrofuran content of 0.39 equivalents and a water content of 0.94 equivalents. In another preferred embodiment, the hydrochloride crystal form J2 of the compound of formula (I) is prepared by heating the hydrochloride crystal form J1 of the compound of formula (I) to 90°C to 130°C. In another preferred embodiment, the hydrochloride crystal form J2 of the compound of formula (I) is a solvate of 2-methyl-tetrahydrofuran and water, wherein the content of 2- methyl-tetrahydrofuran is 0.2 to 0.8 equivalents and the content of water is 0.5 to 2 equivalents. The present invention also provides the hydrochloride crystal form K of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>6.79±0.2∘<annotation encoding="application / x-tex">6.79 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.61±0.2∘<annotation encoding="application / x-tex">11.61 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.93±0.2∘<annotation encoding="application / x-tex">14.93 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.08±0.2∘<annotation encoding="application / x-tex">16.08 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.05±0.2∘<annotation encoding="application / x-tex">18.05 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.63±0.2∘<annotation encoding="application / x-tex">18.63 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.49±0.2∘<annotation encoding="application / x-tex">20.49 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.64±0.2∘<annotation encoding="application / x-tex">20.64 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.52±0.2∘<annotation encoding="application / x-tex">21.52 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.72±0.2∘<annotation encoding="application / x-tex">21.72 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.93±0.2∘<annotation encoding="application / x-tex">21.93 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.68±0.2∘<annotation encoding="application / x-tex">23.68 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.19±0.2∘<annotation encoding="application / x-tex">25.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.25±0.2∘<annotation encoding="application / x-tex">26.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.57±0.2∘<annotation encoding="application / x-tex">26.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.91±0.2∘<annotation encoding="application / x-tex">29.91\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>32.56±0.2∘<annotation encoding="application / x-tex">32.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form K of the compound of Formula I-1 has characteristic diffraction peaks at the following 20 angles: <com:Math><semantics>6.79±0.2∘<annotation encoding="application / x-tex">6.79\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>7.83±0.2∘<annotation encoding="application / x-tex">7.83\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>8.04±0.2∘<annotation encoding="application / x-tex">8.04\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.00±0.2∘<annotation encoding="application / x-tex">10.00\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>10.74±0.2∘<annotation encoding="application / x-tex">10.74\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>11.61±0.2∘<annotation encoding="application / x-tex">11.61 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.25±0.2∘<annotation encoding="application / x-tex">12.25 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.64±0.2∘<annotation encoding="application / x-tex">12.64 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.57±0.2∘<annotation encoding="application / x-tex">13.57 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.93±0.2∘<annotation encoding="application / x-tex">14.93 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.08±0.2∘<annotation encoding="application / x-tex">16.08 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.05±0.2∘<annotation encoding="application / x-tex">18.05 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.63±0.2∘<annotation encoding="application / x-tex">18.63\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.43±0.2∘<annotation encoding="application / x-tex">19.43\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.15±0.2∘<annotation encoding="application / x-tex">20.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.49±0.2∘<annotation encoding="application / x-tex">20.49\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.64±0.2∘<annotation encoding="application / x-tex">20.64\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.52±0.2∘<annotation encoding="application / x-tex">21.52\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.72±0.2∘<annotation encoding="application / x-tex">21.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.93±0.2∘<annotation encoding="application / x-tex">21.93\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.27±0.2∘<annotation encoding="application / x-tex">23.27\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>23.68±0.2∘<annotation encoding="application / x-tex">23.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>24.73±0.2∘<annotation encoding="application / x-tex">24.73\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.19±0.2∘<annotation encoding="application / x-tex">25.19\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.25±0.2∘<annotation encoding="application / x-tex">26.25\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>26.57±0.2∘<annotation encoding="application / x-tex">26.57\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, 27.42±0.2°, 28.02±0.2°, 28.67±0.2°, 29.13±0.2°, 29.91±0.2°, 32.56±0.2°. In another preferred embodiment, the hydrochloride crystal form K has an X-ray powder diffraction pattern substantially as shown in Figure 62. In some embodiments of the present invention, the X-ray powder diffraction (XRPD) pattern of the hydrochloride crystal form K of the compound of Formula I-1 is shown in Figure 62. Table 28 XRPD analysis data for the hydrochloride crystal form K of compound of Formula I-1 [Image disponible dans le document PDF, Image available in the PDF document] [Image disponible dans le document PDF, Image available in the PDF document] In some embodiments of the present invention, the hydrochloride crystal form K of the compound of Formula I-1 has the onsets of the endothermic peaks at <com:Math><semantics>80.73∘C±2∘C<annotation encoding="application / x-tex">80.73^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math> and 171.74°C ± 2°C in its differential scanning calorimetry (DSC) curve, and decomposition of the sample begins at <com:Math><semantics>211.42∘C±2∘C<annotation encoding="application / x-tex">211.42^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>. In another preferred embodiment, the hydrochloride crystal form K has a differential scanning calorimetry pattern substantially as shown in Figure 63. In some embodiments of the present invention, the DSC pattern of the hydrochloride crystal form K of the compound of Formula I-1 is shown in Figure 63. In some embodiments of the present invention, the hydrochloride crystal form K of the compound of Formula I-1 has three weight loss steps at <com:Math><semantics>33.39∘C±2∘C<annotation encoding="application / x-tex">33.39^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>125.00∘C±2∘C<annotation encoding="application / x-tex">125.00^{\circ}C \pm 2^{\circ}C< / annotation>< / semantics>< / com:Math>, and <com:Math><semantics>155.00∘<annotation encoding="application / x-tex">155.00^{\circ}< / annotation>< / semantics>< / com:Math>C <com:Math><semantics>±2∘<annotation encoding="application / x-tex">\pm 2^{\circ}< / annotation>< / semantics>< / com:Math>C in its thermogravimetric analysis (TGA) curve. In another preferred embodiment, the hydrochloride crystal form K has a thermogravimetric analysis pattern substantially as shown in Figure 64. In some embodiments of the present invention, the TGA pattern of the hydrochloride crystal form K of the compound of Formula I-1 is shown in Figure 64. The present invention also provides a method for preparing the hydrochloride crystal form K of the compound of Formula I-1, comprising adding the compound of Formula I-1 and hydrochloric acid to methyl tert-butyl ether, and then performing suspension recrystallization at 50°C or under heating-cooling cycles or slurrying to obtain it, the ratio of the compound of Formula I-1 to hydrochloric acid is selected from 0.8 to 1.2, and the hydrochloride crystal form K of the compound of Formula I-1 is a solvate of methyl tert-butyl ether and water, with a methyl tert-butyl ether content of 0.5 equivalents and a water content of 0.93 equivalents. In another preferred embodiment, the hydrochloride crystal form K of the compound of formula (I) is a solvate of methyl tert-butyl ether and water, wherein the content of methyl tert-butyl ether is 0.1 to 1 equivalent and the content of water is 0.5 to 2 equivalents. The present invention also provides the hydrochloride crystal form L of the compound of Formula I-1, and its X-ray powder diffraction pattern has characteristic diffraction peaks at the following <com:Math><semantics>2θ<annotation encoding="application / x-tex">2\theta< / annotation>< / semantics>< / com:Math> angles: <com:Math><semantics>8.15±0.2∘<annotation encoding="application / x-tex">8.15\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>12.72±0.2∘<annotation encoding="application / x-tex">12.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.59±0.2∘<annotation encoding="application / x-tex">13.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.07±0.2∘<annotation encoding="application / x-tex">15.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.56±0.2∘<annotation encoding="application / x-tex">15.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.60<annotation encoding="application / x-tex">16.60< / annotation>< / semantics>< / com:Math> <com:Math><semantics>±0.2∘<annotation encoding="application / x-tex">\pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.89±0.2∘<annotation encoding="application / x-tex">16.89 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.56±0.2∘<annotation encoding="application / x-tex">17.56 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>19.74±0.2∘<annotation encoding="application / x-tex">19.74 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>20.52±0.2∘<annotation encoding="application / x-tex">20.52 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>21.69±0.2∘<annotation encoding="application / x-tex">21.69 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>22.60±0.2∘<annotation encoding="application / x-tex">22.60 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>25.57±0.2∘<annotation encoding="application / x-tex">25.57 \pm 0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>27.48±0.2∘<annotation encoding="application / x-tex">27.48\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.54±0.2∘<annotation encoding="application / x-tex">29.54\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>29.80±0.2∘<annotation encoding="application / x-tex">29.80\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>. In some embodiments of the present invention, the X-ray powder diffraction pattern of the hydrochloride crystal form L of the compound of Formula I-1 has characteristic diffraction peaks at the following 2θ angles: 7.70±0.2°, 8.15±0.2°, 8.82±0.2°, 9.85±0.2°, 11.25±0.2°, <com:Math><semantics>12.72±0.2∘<annotation encoding="application / x-tex">12.72\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>13.59±0.2∘<annotation encoding="application / x-tex">13.59\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>14.68±0.2∘<annotation encoding="application / x-tex">14.68\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.07±0.2∘<annotation encoding="application / x-tex">15.07\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>15.56±0.2∘<annotation encoding="application / x-tex">15.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.60±0.2∘<annotation encoding="application / x-tex">16.60\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>16.89±0.2∘<annotation encoding="application / x-tex">16.89\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>17.56±0.2∘<annotation encoding="application / x-tex">17.56\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.53±0.2∘<annotation encoding="application / x-tex">18.53\pm0.2^{\circ}< / annotation>< / semantics>< / com:Math>, <com:Math><semantics>18.98±0.2∘<annotation encoding="application / x-...

Claims

1. A compound of formula (I), [Image disponible dans le document PDF, Image available in the PDF document] (I) in an amorphous form or a crystal form or a solvate thereof; wherein m is 1, 2, 3, 4, 5, 6, 7, 8, or 9; n is 0, 0.5, 1, 1.5, 2, 2.5, or 3; and X is selected from the group consisting of: hydrochloric acid, hydrobromic acid, hydrofluoric acid, sulfuric acid, nitric acid, or phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, benzoic acid, methanesulfonic acid, ethanesulfonic acid, p- toluenesulfonic acid, benzenesulfonic acid, naphthalenesulfonic acid, hippuric acid, glycolic acid, or glutaric acid.

2. A crystal form A of the compound of formula (I) according to claim 1, wherein, the compound of formula (I) is I-1, n = 0 n = 0 , and the X-ray powder diffraction pattern of the crystal form A has 20 angles selected from the group consisting of: 14.16 ± 0.2 ∘ 14.16 \pm 0.2^{\circ} , 16.74 ± 0.2 ∘ 16.74 \pm 0.2^{\circ} , and 23.01 ± 0.2 ∘ 23.01 \pm 0.2^{\circ} [Image disponible dans le document PDF, Image available in the PDF document]3. A method for preparing the crystal form A according to claim 2, wherein, the method comprises the following steps: a. dissolving or dispersing compound I-1 in acetonitrile, an alcoholic solvent, an ester solvent, an ether solvent, or a mixed solvent of the alcoholic solvent and water at a volume ratio of 1-5 times; b. performing recrystallization or slurrying; wherein the alcoholic solvent is selected from the group consisting of: methanol, ethanol, isopropanol, or a combination thereof; the ester solvent is selected from the group consisting of: ethyl acetate, isopropyl acetate, methyl formate, ethyl formate, isopropyl formate, or a combination thereof; the ether solvent is selected from the group consisting of: methyl tert-butyl ether, tetrahydrofuran, ethylene glycol dimethyl ether, or a combination thereof; the mixed solvent of the alcoholic solvent and water is selected from the group consisting of: a mixture of methanol and water, a mixture of ethanol and water, or a mixture of isopropanol and water; wherein the volume ratio of the alcoholic solvent to water is 1: ( 0.1 − 1.5 ) (0.1-1.5) .

4. A crystal form of the compound of formula (I) according to claim 1, wherein, the compound of formula (I) is a salt formed by compound I-1 and an acid; wherein the acid is an inorganic acid or an organic acid; preferably, the inorganic acid is selected from the group consisting of: hydrochloric acid, hydrobromic acid, hydrofluoric acid, sulfuric acid, nitric acid, or phosphoric acid; preferably, the organic acid is selected from the group consisting of: formic acid, acetic acid, trifluoroacetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, benzoic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, benzenesulfonic acid, naphthalenesulfonic acid, hippuric acid, glycolic acid, or glutaric acid; preferably, the molar ratio of compound I-1 to the acid is 1: (0.8–3); more preferably, 1: (0.8–2).

5. The crystal form according to claim 4, wherein, the crystal form is the maleate crystal form A of the compound of formula I-1, the X-ray powder diffraction pattern of the maleate crystal form A has 20 angles selected from the group consisting of: 15.17 ± 0.2 ∘ 15.17 \pm 0.2^{\circ} , 23.02 ± 0.00 23.02 \pm 0.00 0.2 ∘ 0.2^{\circ} , 24.42 ± 0.2 ∘ 24.42 \pm 0.2^{\circ} ; the crystal form is the monomaleate crystal form B of the compound of Formula I-1, the X-ray powder diffraction pattern of the monomaleate crystal form B has 20 angles selected from the group consisting of: 16.57 ± 0.2 ∘ 16.57\pm0.2^{\circ} , 17.38 ± 0.2 ∘ 17.38\pm0.2^{\circ} , and 20.39 ± 0.2 ∘ 20.39\pm0.2^{\circ} ; the crystal form is the fumarate crystal form A of the compound of formula I-1, the X- ray powder diffraction pattern of the fumarate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 5.11 ± 0.2 ∘ 5.11\pm0.2^{\circ} , 14.23 ± 0.2 ∘ 14.23\pm0.2^{\circ} , 28.85 ± 0.2 ∘ 28.85\pm0.2^{\circ} ; the crystal form is the hemifumarate crystal form B of the compound of formula I-1, the X-ray powder diffraction pattern of the hemifumarate crystal form B has 2θ angles selected from the group consisting of: 5.12 ± 0.2 ∘ 5.12\pm0.2^{\circ} , 14.24 ± 0.2 ∘ 14.24\pm0.2^{\circ} , 10.20 ± 0.2 ∘ 10.20\pm0.2^{\circ} ; the crystal form is the monoglycolate crystal form A of the compound of formula I-1, the X-ray powder diffraction pattern of the monoglycolate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 18.22±0.2°, 22.83±0.2°, 26.41±0.2°; the crystal form is the glycolate crystal form B of the compound of formula I-1, the X- ray powder diffraction pattern of the glycolate crystal form B has 2 θ 2\theta angles selected from the group consisting of: 13.87 ± 0.2 ∘ 13.87\pm0.2^{\circ} , 17.30 ± 0.2 ∘ 17.30\pm0.2^{\circ} , 19.49 ± 0.2 ∘ 19.49\pm0.2^{\circ} , 23.50 ± 0.2 ∘ 23.50\pm0.2^{\circ} ; the crystal form is of the compound of formula I-1, the X-ray powder diffraction pattern of the mono-L-malate crystal form A has 2θ angles selected from the group consisting of: 17.99 ± 0.2 ∘ 17.99\pm0.2^{\circ} , 22.58 ± 0.2 ∘ 22.58\pm0.2^{\circ} , and 24.00 ± 0.2 ∘ 24.00\pm0.2^{\circ} ; the crystal form is the monosuccinate crystal form A of the compound of formula I-1, the X-ray powder diffraction pattern of the monosuccinate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 18.40 ± 0.2 ∘ 18.40\pm0.2^{\circ} , 24.09 ± 0.2 ∘ 24.09\pm0.2^{\circ} , and 24.62 ± 0.2 ∘ 24.62\pm0.2^{\circ} ; the crystal form is sulfate crystal form A of the compound of formula I-1, the X-ray powder diffraction pattern of sulfate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 14.97 ± 0.2 ∘ 14.97\pm0.2^{\circ} , 20.21 ± 0.2 ∘ 20.21\pm0.2^{\circ} , 22.58 ± 0.2 ∘ 22.58\pm0.2^{\circ} ; the crystal form is the L-tartrate crystal form A of the compound of Formula I-1, the X- ray powder diffraction pattern of the L-tartrate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 5.53 ± 0.2 ∘ 5.53\pm0.2^{\circ} , 16.95 ± 0.2 ∘ 16.95\pm0.2^{\circ} , 20.79 ± 0.2 ∘ 20.79\pm0.2^{\circ} ; the crystal form is the hippurate crystal form A of the compound of Formula I-1, the X- ray powder diffraction pattern of the hippurate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 6.17 ± 0.2 ∘ 6.17\pm0.2^{\circ} , 12.30 ± 0.2 ∘ 12.30\pm0.2^{\circ} , and 18.78 ± 0.2 ∘ 18.78\pm0.2^{\circ} ; the crystal form is the glutarate crystal form A of the compound of Formula I-1, the X- ray powder diffraction pattern of the glutarate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 17.82 ± 0.2 ∘ 17.82\pm0.2^{\circ} , 23.20 ± 0.2 ∘ 23.20\pm0.2^{\circ} , and 24.47 ± 0.2 ∘ 24.47\pm0.2^{\circ} ; the crystal form is the p-toluenesulfonate crystal form A of the compound of Formula I-1, the X-ray powder diffraction pattern of the p-toluenesulfonate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 19.12 ± 0.2 ∘ 19.12\pm0.2^{\circ} , 20.11 ± 0.2 ∘ 20.11\pm0.2^{\circ} , and 20.53 ± 0.2 ∘ 20.53\pm0.2^{\circ} ; the crystal form is the p-toluenesulfonate crystal form B of the compound of formula I- 1, the X-ray powder diffraction pattern of p-toluenesulfonate crystal form B has 2θ angles selected from the group consisting of: 13.95 ± 0.2 ∘ 13.95\pm0.2^{\circ} , 19.52 ± 0.2 ∘ 19.52\pm0.2^{\circ} , and 25.40 ± 0.2 ∘ 25.40\pm0.2^{\circ} ; the crystal form is the methanesulfonate crystal form A of the compound of formula I- 1, the X-ray powder diffraction pattern of the methanesulfonate crystal form A has 2 θ 2\theta angles selected from the group consisting of: 19.57 ± 0.2 ∘ 19.57\pm0.2^{\circ} , 14.27 ± 0.2 ∘ 14.27\pm0.2^{\circ} , 24.99 ± 0.2 ∘ 24.99\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form C1 of the compound of Formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form C1 has 2 θ 2\theta angles selected from the group consisting of: 7.73 ± 0.2 ∘ 7.73\pm0.2^{\circ} , 19.57 ± 0.2 ∘ 19.57\pm0.2^{\circ} , 19.78 ± 0.2 ∘ 19.78\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form C2 of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form C2 has 2 θ 2\theta angles selected from the group consisting of: 7.79 ± 0.2 ∘ 7.79\pm0.2^{\circ} , 19.66 ± 0.2 ∘ 19.66\pm0.2^{\circ} , 19.82 ± 0.2 ∘ 19.82\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form D of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form D has 2 θ 2\theta angles selected from the group consisting of: 15.93 ± 0.2 ∘ 15.93\pm0.2^{\circ} , 20.09 ± 0.2 ∘ 20.09\pm0.2^{\circ} , 20.41 ± 0.2 ∘ 20.41\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form E1 of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form E1 has 2 θ 2\theta angles selected from the group consisting of: 7.90 ± 0.2 ∘ 7.90\pm0.2^{\circ} , 14.06 ± 0.2 ∘ 14.06\pm0.2^{\circ} , 20.19 ± 0.2 ∘ 20.19\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form E2 of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form E2 has 2θ angles selected from the group consisting of: 7.88 ± 0.2 ∘ 7.88\pm0.2^{\circ} , 14.14 ± 0.2 ∘ 14.14\pm0.2^{\circ} , 19.75 ± 0.2 ∘ 19.75\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form F of the compound of Formula I-1, wherein the X-ray powder diffraction pattern of the hydrochloride crystal form F has 2 θ 2\theta angles selected from the group consisting of: 7.65 ± 0.2 ∘ 7.65\pm0.2^{\circ} , 11.47 ± 0.2 ∘ 11.47\pm0.2^{\circ} , and 13.93 ± 0.2 ∘ 13.93\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form G of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form G has 2 θ 2\theta angles selected from the group consisting of: 15.52 ± 0.2 ∘ 15.52\pm0.2^{\circ} , 16.77 ± 0.2 ∘ 16.77\pm0.2^{\circ} , and 23.04 ± 0.2 ∘ 23.04\pm0.2^{\circ} ; the crystal form is the hydrochloride crystal form H of the compound of formula I-1, the X-ray powder diffraction pattern of the hydrochloride crystal form H has 2 θ 2\theta angles selected from the group consisting of: 5.83 ± 0.2 ∘ 5.83\pm0.2^{\circ} , 16.67 ± 0.2 ∘ 16.67\pm0.2^{\circ} , 18.40 ± 0.2 ∘ 18.40\pm0.2^{\circ} ; the crystal form is hydrochloride crystal form I, the X-ray powder diffraction pattern of the hydrochloride crystal form I has 20 angles selected from the group consisting of: 6.68 ± 6.68 \pm 0.2 ∘ 0.2^{\circ} , 13.34 ± 0.2 ∘ 13.34 \pm 0.2^{\circ} , and 21.42 ± 0.2 ∘ 21.42 \pm 0.2^{\circ} ; the crystal form is hydrochloride crystal form J1, the X-ray powder diffraction pattern of hydrochloride crystal form J1 comprises 2 θ 2\theta angles selected from the group consisting of: 6.80 ± 0.2 ∘ 6.80\pm0.2^{\circ} , 14.87 ± 0.2 ∘ 14.87\pm0.2^{\circ} , and 20.41 ± 0.2 ∘ 20.41\pm0.2^{\circ} ; the crystal form is hydrochloride crystal form J2, the X-ray powder diffraction pattern of hydrochloride crystal form J2 has 2 θ 2\theta angles selected from the group consisting of: 14.69 ± 0.2 ∘ \pm 0.2^{\circ} , 18.89 ± 0.2 ∘ \pm 0.2^{\circ} , and 22.23 ± 0.2 ∘ \pm 0.2^{\circ} ; the crystal form is hydrochloride crystal form K, the X-ray powder diffraction pattern of the hydrochloride crystal form K has 2 θ 2\theta angles selected from the group consisting of: 14.93 ± 0.2 ∘ 14.93 \pm 0.2^{\circ} , 16.08 ± 0.2 ∘ 16.08 \pm 0.2^{\circ} , and 23.68 ± 0.2 ∘ 23.68 \pm 0.2^{\circ} ; the crystal form is hydrochloride crystal form L, the X-ray powder diffraction pattern of hydrochloride crystal form L has 20 angles selected from the group consisting of: 16.89 ± 16.89 \pm 0.2 ∘ 0.2^{\circ} , 21.69 ± 0.2 ∘ 21.69 \pm 0.2^{\circ} , and 22.60 ± 0.2 ∘ 22.60 \pm 0.2^{\circ} ; the crystal form is hydrochloride crystal form M, the X-ray powder diffraction pattern of hydrochloride crystal form M has 2 θ 2\theta angles selected from the group consisting of: 14.17 ± 0.2 ∘ \pm 0.2^{\circ} , 20.82 ± 0.2 ∘ \pm 0.2^{\circ} , and 22.60 ± 0.2 ∘ \pm 0.2^{\circ} ; the crystal form is hydrochloride crystal form N, the X-ray powder diffraction pattern of hydrochloride crystal form N has 2θ angles selected from the group consisting of: 16.19 ± 0.2 ∘ \pm 0.2^{\circ} , 20.10 ± 0.2 ∘ \pm 0.2^{\circ} , and 28.42 ± 0.2 ∘ \pm 0.2^{\circ} ; or the crystal form is hydrochloride crystal form O, the X-ray powder diffraction pattern of hydrochloride crystal form O has 2θ angles selected from the group consisting of: 15.51 ± 0.2 ∘ \pm 0.2^{\circ} , 18.36 ± 0.2 ∘ 18.36 \pm 0.2^{\circ} , and 20.17 ± 0.2 ∘ 20.17 \pm 0.2^{\circ} .

6. The crystal form according to claim 5, wherein, the X-ray powder diffraction pattern of the maleate crystal form A further comprises one or more 2θ angles selected from the group consisting of: 5.82 ± 0.2 ∘ 5.82\pm0.2^{\circ} , 9.86 ± 0.2 ∘ 9.86\pm0.2^{\circ} , 11.06 ± 0.2 ∘ 11.06\pm0.2^{\circ} , 11.29 ± 0.2 ∘ 11.29\pm0.2^{\circ} , 11.64 ± 0.2 ∘ 11.64\pm0.2^{\circ} , 11.90 ± 0.2 ∘ 11.90\pm0.2^{\circ} 0.2 0.2 °, 12.72 ± 0.2 12.72 \pm 0.2 °, 13.04 ± 0.2 13.04 \pm 0.2 °, 15.66 ± 0.2 15.66 \pm 0.2 °, 16.36 ± 0.2 16.36 \pm 0.2 °, 17.70 ± 0.2 17.70 \pm 0.2 °, 17.88 ± 0.2 17.88 \pm 0.2 °, 18.11 ± 0.2 ∘ 18.11\pm0.2^{\circ} , 18.35 ± 0.2 ∘ 18.35\pm0.2^{\circ} , 18.61 ± 0.2 ∘ 18.61\pm0.2^{\circ} , 19.41 ± 0.2 ∘ 19.41\pm0.2^{\circ} , 20.16 ± 0.2 ∘ 20.16\pm0.2^{\circ} , 20.38 ± 0.2 ∘ 20.38\pm0.2^{\circ} , 20.69 ± 0.2 ∘ 20.69\pm0.2^{\circ} , 21.32 ± 0.2 ∘ 21.32\pm0.2^{\circ} , 21.62 ± 0.2 ∘ 21.62\pm0.2^{\circ} , 22.28 ± 0.2 ∘ 22.28\pm0.2^{\circ} , 22.71 ± 0.2 ∘ 22.71\pm0.2^{\circ} , 25.00 ± 0.2 ∘ 25.00\pm0.2^{\circ} , 25.34 ± 0.2 ∘ 25.34\pm0.2^{\circ} , 26.24 ± 0.2 ∘ 26.24\pm0.2^{\circ} , 26.77 ± 0.2 ∘ 26.77\pm0.2^{\circ} , 29.85 ± 0.2 ∘ 29.85\pm0.2^{\circ} , 34.09 ± 0.2 ∘ 34.09\pm0.2^{\circ} ; the monomaleate crystal form B further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the monomaleate crystal form B further has one or more 2θ angles selected from the group consisting of: 7.98±0.2°, 8.29±0.2°, 10.27 ± 0.2 ∘ 10.27\pm0.2^{\circ} , 11.61 ± 0.2 ∘ 11.61\pm0.2^{\circ} , 13.21 ± 0.2 ∘ 13.21\pm0.2^{\circ} , 13.99 ± 0.2 ∘ 13.99\pm0.2^{\circ} , 14.52 ± 0.2 ∘ 14.52\pm0.2^{\circ} , 15.25 ± 0.2 ∘ 15.25\pm0.2^{\circ} , 15.95 ± 0.2 ∘ 15.95\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 16.89 ± 0.2 ∘ 16.89 \pm 0.2^{\circ} , 18.06 ± 0.2 ∘ 18.06 \pm 0.2^{\circ} , 20.61 ± 0.2 ∘ 20.61 \pm 0.2^{\circ} , 21.25 ± 0.2 ∘ 21.25 \pm 0.2^{\circ} , 21.61 ± 0.2 ∘ 21.61 \pm 0.2^{\circ} , 22.17 ± 0.2 ∘ 22.17 \pm 0.2^{\circ} , 23.31 ± 0.2 ∘ 23.31 \pm 0.2^{\circ} , 23.54 ± 0.2 ∘ 23.54\pm0.2^{\circ} , 23.98 ± 0.2 ∘ 23.98\pm0.2^{\circ} , 24.70 ± 0.2 ∘ 24.70\pm0.2^{\circ} , 24.93 ± 0.2 ∘ 24.93\pm0.2^{\circ} , 25.32 ± 0.2 ∘ 25.32\pm0.2^{\circ} , 25.91 ± 0.2 ∘ 25.91\pm0.2^{\circ} , 26.55 ± 0.2 ∘ 26.55\pm0.2^{\circ} , 27.24 ± 0.2 ∘ 27.24\pm0.2^{\circ} , 28.23 ± 0.2 ∘ 28.23\pm0.2^{\circ} , 28.54 ± 0.2 ∘ 28.54\pm0.2^{\circ} , 29.00 ± 0.2 ∘ 29.00\pm0.2^{\circ} , 29.47 ± 0.2 ∘ 29.47\pm0.2^{\circ} , 29.71 ± 0.2 ∘ 29.71\pm0.2^{\circ} , 32.64 ± 0.2 ∘ 32.64\pm0.2^{\circ} , 35.12 ± 0.2 ∘ 35.12\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the monomaleate crystal form B has the onset of the endothermic peak at 213.92 ∘ C ± 2 ∘ C 213.92^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the monomaleate crystal form B has two weight loss steps at 24.00 ∘ C ± 2 ∘ C 24.00^{\circ}\text{C} \pm 2^{\circ}\text{C} and 180.00 ∘ C ± 2 ∘ C 180.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins above 250.00 ∘ C ± 2 ∘ C ; 250.00^{\circ}\text{C} \pm 2^{\circ}\text{C}; the X-ray powder diffraction pattern of the fumarate crystal form A further has one or more 20 angles selected from the group consisting of: 7.26 ± 0.2 ∘ 7.26\pm0.2^{\circ} , 10.20 ± 0.2 ∘ 10.20\pm0.2^{\circ} , 10.51 ± 0.2 ∘ 10.51\pm0.2^{\circ} , 14.47 ± 0.2 ∘ 14.47 \pm 0.2^{\circ} , 14.93 ± 0.2 ∘ 14.93 \pm 0.2^{\circ} , 16.17 ± 0.2 ∘ 16.17 \pm 0.2^{\circ} , 17.03 ± 0.2 ∘ 17.03 \pm 0.2^{\circ} , 17.90 ± 0.2 ∘ 17.90 \pm 0.2^{\circ} , 18.79 ± 0.2 ∘ 18.79 \pm 0.2^{\circ} , 19.44 ± 0.2 ∘ 19.44 \pm 0.2^{\circ} , 20.19 ± 0.2 ∘ 20.19\pm0.2^{\circ} , 20.80 ± 0.2 ∘ 20.80\pm0.2^{\circ} , 22.48 ± 0.2 ∘ 22.48\pm0.2^{\circ} , 23.07 ± 0.2 ∘ 23.07\pm0.2^{\circ} , 23.74 ± 0.2 ∘ 23.74\pm0.2^{\circ} , 24.07 ± 0.2 ∘ 24.07\pm0.2^{\circ} , 27.06 ± 0.2 ∘ 27.06\pm0.2^{\circ} , 27.85 ± 0.2 ∘ 27.85\pm0.2^{\circ} , 28.30 ± 0.2 ∘ 28.30\pm0.2^{\circ} , 29.46 ± 0.2 ∘ 29.46\pm0.2^{\circ} , 38.24 ± 0.2 ∘ 38.24\pm0.2^{\circ} ; the hemifumarate crystal form B further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hemifumarate crystal form B further comprises one or more 2 θ 2\theta angles selected from the group consisting of: 7.27 ± 0.2 ∘ 7.27\pm0.2^{\circ} , 7.48 ± 0.2 ∘ 7.48\pm0.2^{\circ} , 8.77 ± 0.2 ∘ 8.77 \pm 0.2^{\circ} , 9.18 ± 0.2 ∘ 9.18 \pm 0.2^{\circ} , 9.74 ± 0.2 ∘ 9.74 \pm 0.2^{\circ} , 10.53 ± 0.2 ∘ 10.53 \pm 0.2^{\circ} , 14.96 ± 0.2 ∘ 14.96 \pm 0.2^{\circ} , 16.09 ± 0.2 ∘ 16.09 \pm 0.2^{\circ} , 16.99 ± 0.2 ∘ 16.99 \pm 0.2^{\circ} , 17.61 ± 0.2 ∘ 17.61\pm0.2^{\circ} , 17.95 ± 0.2 ∘ 17.95\pm0.2^{\circ} , 18.81 ± 0.2 ∘ 18.81\pm0.2^{\circ} , 19.45 ± 0.2 ∘ 19.45\pm0.2^{\circ} , 20.22 ± 0.2 ∘ 20.22\pm0.2^{\circ} , 20.43 ± 0.2 ∘ 20.43\pm0.2^{\circ} , 20.84 ± 0.2 ∘ 20.84\pm0.2^{\circ} , 22.51 ± 0.2 ∘ 22.51\pm0.2^{\circ} , 23.11 ± 0.2 ∘ 23.11\pm0.2^{\circ} , 23.76 ± 0.2 ∘ 23.76\pm0.2^{\circ} , 24.19 ± 0.2 ∘ 24.19\pm0.2^{\circ} , 25.24 ± 0.2 ∘ 25.24\pm0.2^{\circ} , 27.04 ± 0.2 ∘ 27.04\pm0.2^{\circ} , 27.90 ± 0.2 ∘ 27.90\pm0.2^{\circ} , 28.25 ± 0.2 ∘ 28.25\pm0.2^{\circ} , 28.75 ± 0.2 ∘ 28.75\pm0.2^{\circ} , 29.73 ± 0.2 ∘ 29.73\pm0.2^{\circ} , 30.14 ± 0.2 ∘ 30.14\pm0.2^{\circ} , 30.77 ± 0.2 ∘ 30.77\pm0.2^{\circ} , 31.28 ± 0.2 ∘ 31.28\pm0.2^{\circ} , 33.95 ± 0.2 ∘ 33.95\pm0.2^{\circ} , 34.52 ± 0.2 ∘ 34.52\pm0.2^{\circ} , 37.07 ± 0.2 ∘ 37.07\pm0.2^{\circ} , 38.26 ± 0.2 ∘ 38.26\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hemifumarate crystal form B has the onsets of the endothermic peaks at 21.34 ∘ C ± 2 ∘ C 21.34^{\circ}C \pm 2^{\circ}C , 172.21 ∘ C ± 2 ∘ C 172.21^{\circ}C \pm 2^{\circ}C , and 234.34 ∘ C ± 2 ∘ C 234.34^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hemifumarate crystal form B has three weight loss steps at 31.90 ∘ C ± 2 ∘ C 31.90^{\circ}\text{C} \pm 2^{\circ}\text{C} , 90.00 ∘ C ± 2 ∘ C 90.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 190.00 ∘ C ± 2 ∘ C 190.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins above 270.00 ∘ C ± 2 ∘ C 270.00^{\circ}\text{C} \pm 2^{\circ}\text{C} ; the monoglycolate crystal form A further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the monoglycolate crystal form A also has one or more 2 θ 2\theta angles selected from the group consisting of: 6.37 ± 0.2 ∘ 6.37\pm0.2^{\circ} , 10.37 ± 0.2 ∘ 10.37\pm0.2^{\circ} , 11.09 ± 0.2 ∘ 11.09\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 11.70 ± 0.2 ∘ 11.70 \pm 0.2^{\circ} , 12.69 ± 0.2 ∘ 12.69 \pm 0.2^{\circ} , 13.55 ± 0.2 ∘ 13.55 \pm 0.2^{\circ} , 14.06 ± 0.2 ∘ 14.06 \pm 0.2^{\circ} , 15.97 ± 0.2 ∘ 15.97 \pm 0.2^{\circ} , 17.34 ± 0.2 ∘ 17.34 \pm 0.2^{\circ} , 18.47 ± 0.2 ∘ 18.47\pm0.2^{\circ} , 19.09 ± 0.2 ∘ 19.09\pm0.2^{\circ} , 20.41 ± 0.2 ∘ 20.41\pm0.2^{\circ} , 20.71 ± 0.2 ∘ 20.71\pm0.2^{\circ} , 21.25 ± 0.2 ∘ 21.25\pm0.2^{\circ} , 22.06 ± 0.2 ∘ 22.06\pm0.2^{\circ} , 22.43 ± 0.2 ∘ 22.43\pm0.2^{\circ} , 23.49 ± 0.2 ∘ 23.49\pm0.2^{\circ} , 24.09 ± 0.2 ∘ 24.09\pm0.2^{\circ} , 24.79 ± 0.2 ∘ 24.79\pm0.2^{\circ} , 25.21 ± 0.2 ∘ 25.21\pm0.2^{\circ} , 27.23 ± 0.2 ∘ 27.23\pm0.2^{\circ} , 28.00 ± 0.2 ∘ 28.00\pm0.2^{\circ} , 29.59 ± 0.2 ∘ 29.59\pm0.2^{\circ} , 30.44 ± 0.2 ∘ 30.44\pm0.2^{\circ} , 30.96 ± 0.2 ∘ 30.96\pm0.2^{\circ} , 38.67 ± 0.2 ∘ 38.67\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the monoglycolate crystal form A has the onsets of the endothermic peaks at 109.66 ∘ C ± 2 ∘ C 109.66^{\circ}\text{C} \pm 2^{\circ}\text{C} and 198.83 ∘ C ± 2 ∘ C 198.83^{\circ}\text{C} \pm 2^{\circ}\text{C} ; c. the thermogravimetric analysis curve of the monoglycolate crystal form A has three weight loss steps at 33.00 ∘ C ± 2 ∘ C 33.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , 100.00 ∘ C ± 2 ∘ C 100.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 165.00 ∘ C ± 2 ∘ C 165.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins above 200.00 ∘ C ± 2 ∘ C 200.00^{\circ}\text{C} \pm 2^{\circ}\text{C} ; the X-ray powder diffraction pattern of the glycolate crystal form B further has one or more 20 angles selected from the group consisting of: 5.95 ± 0.2 ∘ 5.95\pm0.2^{\circ} , 11.06 ± 0.2 ∘ 11.06\pm0.2^{\circ} , 12.20 ± 0.2 ∘ 12.20\pm0.2^{\circ} , 15.01 ± 0.2 ∘ 15.01 \pm 0.2^{\circ} , 15.79 ± 0.2 ∘ 15.79 \pm 0.2^{\circ} , 15.97 ± 0.2 ∘ 15.97 \pm 0.2^{\circ} , 16.44 ± 0.2 ∘ 16.44 \pm 0.2^{\circ} , 16.63 ± 0.2 ∘ 16.63 \pm 0.2^{\circ} , 16.79 ± 0.2 ∘ 16.79 \pm 0.2^{\circ} , 17.90 ± 0.2 ∘ 17.90 \pm 0.2^{\circ} , 18.33 ± 0.2 ∘ 18.33\pm0.2^{\circ} , 18.91 ± 0.2 ∘ 18.91\pm0.2^{\circ} , 21.59 ± 0.2 ∘ 21.59\pm0.2^{\circ} , 22.18 ± 0.2 ∘ 22.18\pm0.2^{\circ} , 22.80 ± 0.2 ∘ 22.80\pm0.2^{\circ} , 23.16 ± 0.2 ∘ 23.16\pm0.2^{\circ} , 23.93 ± 0.2 ∘ 23.93\pm0.2^{\circ} , 24.49 ± 0.2 ∘ 24.49\pm0.2^{\circ} , 25.13 ± 0.2 ∘ 25.13\pm0.2^{\circ} , 26.68 ± 0.2 ∘ 26.68\pm0.2^{\circ} , 27.95 ± 0.2 ∘ 27.95\pm0.2^{\circ} , 30.49 ± 0.2 ∘ 30.49\pm0.2^{\circ} , 31.62 ± 0.2 ∘ 31.62\pm0.2^{\circ} , 32.27 ± 0.2 ∘ 32.27\pm0.2^{\circ} ; the mono-L-malate crystal form A further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the mono-L-malate crystal form A also has one or more 2 θ 2\theta angles selected from the group consisting of: 6.01 ± 0.2 ∘ 6.01\pm0.2^{\circ} , 10.06 ± 0.2 ∘ 10.06\pm0.2^{\circ} , 11.04 ± 0.2 ∘ 11.04\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 11.98 ± 0.2 ∘ 11.98 \pm 0.2^{\circ} , 12.66 ± 0.2 ∘ 12.66 \pm 0.2^{\circ} , 12.86 ± 0.2 ∘ 12.86 \pm 0.2^{\circ} , 13.39 ± 0.2 ∘ 13.39 \pm 0.2^{\circ} , 15.15 ± 0.2 ∘ 15.15 \pm 0.2^{\circ} , 15.62 ± 0.2 ∘ 15.62 \pm 0.2^{\circ} , 16.46 ± 0.2 ∘ 16.46\pm0.2^{\circ} , 17.27 ± 0.2 ∘ 17.27\pm0.2^{\circ} , 18.58 ± 0.2 ∘ 18.58\pm0.2^{\circ} , 19.53 ± 0.2 ∘ 19.53\pm0.2^{\circ} , 19.77 ± 0.2 ∘ 19.77\pm0.2^{\circ} , 20.25 ± 0.2 ∘ 20.25\pm0.2^{\circ} , 21.01 ± 0.2 ∘ 21.01\pm0.2^{\circ} , 21.57 ± 0.2 ∘ 21.57\pm0.2^{\circ} , 22.04 ± 0.2 ∘ 22.04\pm0.2^{\circ} , 23.67 ± 0.2 ∘ 23.67\pm0.2^{\circ} , 24.50 ± 0.2 ∘ 24.50\pm0.2^{\circ} , 25.00 ± 0.2 ∘ 25.00\pm0.2^{\circ} , 27.34 ± 0.2 ∘ 27.34\pm0.2^{\circ} , 28.54 ± 0.2 ∘ 28.54\pm0.2^{\circ} , 28.91 ± 0.2 ∘ 28.91\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 29.40 ± 0.2 ∘ 29.40 \pm 0.2^{\circ} , 29.89 ± 0.2 ∘ 29.89 \pm 0.2^{\circ} , 30.53 ± 0.2 ∘ 30.53 \pm 0.2^{\circ} , 31.33 ± 0.2 ∘ 31.33 \pm 0.2^{\circ} , 33.67 ± 0.2 ∘ 33.67 \pm 0.2^{\circ} , 36.16 ± 0.2 ∘ 36.16 \pm 0.2^{\circ} ; b. the differential scanning calorimetry curve of the mono-L-malate crystal form A has the onset of the endothermic peak at 204.74 ∘ C ± 2 ∘ C 204.74^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the mono-L-malate crystal form A has two weight loss steps at 33.00 ∘ C ± 2 ∘ C 33.00^{\circ}\text{C} \pm 2^{\circ}\text{C} and 185.00 ∘ C ± 2 ∘ C 185.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 250.00 ∘ C 250.00^{\circ}\text{C} ± 2 \pm 2 °C; the monosuccinate crystal form A further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the monosuccinate crystal form A also has one or more 2θ angles selected from the group consisting of: 6.15 ± 0.2 ∘ 6.15\pm0.2^{\circ} , 9.64 ± 0.2 ∘ 9.64\pm0.2^{\circ} , 9.95 ± 0.2 ∘ 9.95\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 11.19 ± 0.2 ∘ 11.19 \pm 0.2^{\circ} , 12.26 ± 0.2 ∘ 12.26 \pm 0.2^{\circ} , 12.70 ± 0.2 ∘ 12.70 \pm 0.2^{\circ} , 13.30 ± 0.2 ∘ 13.30 \pm 0.2^{\circ} , 14.95 ± 0.2 ∘ 14.95 \pm 0.2^{\circ} , 15.25 ± 0.2 ∘ 15.25 \pm 0.2^{\circ} , 16.18 ± 0.2 ∘ 16.18\pm0.2^{\circ} , 17.59 ± 0.2 ∘ 17.59\pm0.2^{\circ} , 18.89 ± 0.2 ∘ 18.89\pm0.2^{\circ} , 19.11 ± 0.2 ∘ 19.11\pm0.2^{\circ} , 19.73 ± 0.2 ∘ 19.73\pm0.2^{\circ} , 20.28 ± 0.2 ∘ 20.28\pm0.2^{\circ} , 20.90 ± 0.2 ∘ 20.90\pm0.2^{\circ} , 21.27 ± 0.2 ∘ 21.27\pm0.2^{\circ} , 21.64 ± 0.2 ∘ 21.64\pm0.2^{\circ} , 22.12 ± 0.2 ∘ 22.12\pm0.2^{\circ} , 23.12 ± 0.2 ∘ 23.12\pm0.2^{\circ} , 23.83 ± 0.2 ∘ 23.83\pm0.2^{\circ} , 24.35 ± 0.2 ∘ 24.35\pm0.2^{\circ} , 24.93 ± 0.2 ∘ 24.93\pm0.2^{\circ} , 25.17 ± 0.2 ∘ 25.17\pm0.2^{\circ} , 26.05 ± 0.2 ∘ 26.05\pm0.2^{\circ} , 27.00 ± 0.2 ∘ 27.00\pm0.2^{\circ} , 28.27 ± 0.2 ∘ 28.27\pm0.2^{\circ} , 28.72 ± 0.2 ∘ 28.72\pm0.2^{\circ} , 30.12 ± 0.2 ∘ 30.12\pm0.2^{\circ} , 31.20 ± 0.2 ∘ 31.20\pm0.2^{\circ} , 33.57 ± 0.2 ∘ 33.57\pm0.2^{\circ} , 34.13 ± 0.2 ∘ 34.13\pm0.2^{\circ} , 34.58 ± 0.2 ∘ 34.58\pm0.2^{\circ} , 35.60 ± 0.2 ∘ 35.60\pm0.2^{\circ} , 38.23 ± 0.2 ∘ 38.23\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the monosuccinate crystal form A has the onsets of the endothermic peaks at 72.75 ∘ C ± 2 ∘ C 72.75^{\circ}C \pm 2^{\circ}C , 146.41 ∘ C ± 2 ∘ C 146.41^{\circ}C \pm 2^{\circ}C , and 175.72 ∘ C ± 2 ∘ C 175.72^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the monosuccinate crystal form A has three weight loss steps at 33.00 ∘ C ± 2 ∘ C 33.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , 90.00 ∘ C ± 2 ∘ C 90.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 160.00 ∘ C ± 2 ∘ C 160.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins above 260.00 ∘ C ± 2 ∘ C 260.00^{\circ}\text{C} \pm 2^{\circ}\text{C} ; the X-ray powder diffraction pattern of the sulfate crystal form A further comprises one or more 20 angles selected from the group consisting of: 6.74 ± 0.2 ∘ 6.74\pm0.2^{\circ} , 9.56 ± 0.2 ∘ 9.56\pm0.2^{\circ} , 12.89 ± 0.2 ∘ 12.89\pm0.2^{\circ} , 13.78 ± 0.2 ∘ 13.78 \pm 0.2^{\circ} , 14.68 ± 0.2 ∘ 14.68 \pm 0.2^{\circ} , 15.49 ± 0.2 ∘ 15.49 \pm 0.2^{\circ} , 15.70 ± 0.2 ∘ 15.70 \pm 0.2^{\circ} , 16.41 ± 0.2 ∘ 16.41 \pm 0.2^{\circ} , 16.90 ± 0.2 ∘ 16.90 \pm 0.2^{\circ} , 18.47 ± 0.2 ∘ 18.47 \pm 0.2^{\circ} , 18.68 ± 0.2 ∘ 18.68\pm0.2^{\circ} , 18.86 ± 0.2 ∘ 18.86\pm0.2^{\circ} , 19.33 ± 0.2 ∘ 19.33\pm0.2^{\circ} , 19.87 ± 0.2 ∘ 19.87\pm0.2^{\circ} , 20.70 ± 0.2 ∘ 20.70\pm0.2^{\circ} , 21.54 ± 0.2 ∘ 21.54\pm0.2^{\circ} , 21.76 ± 0.2 ∘ 21.76\pm0.2^{\circ} , 22.25 ± 0.2 ∘ 22.25\pm0.2^{\circ} , 23.75 ± 0.2 ∘ 23.75\pm0.2^{\circ} , 24.11 ± 0.2 ∘ 24.11\pm0.2^{\circ} , 24.50 ± 0.2 ∘ 24.50\pm0.2^{\circ} , 25.25 ± 0.2 ∘ 25.25\pm0.2^{\circ} , 25.86 ± 0.2 ∘ 25.86\pm0.2^{\circ} , 26.10 ± 0.2 ∘ 26.10\pm0.2^{\circ} , 26.71 ± 0.2 ∘ 26.71\pm0.2^{\circ} , 26.96 ± 0.2 ∘ 26.96\pm0.2^{\circ} , 27.73 ± 0.2 ∘ 27.73\pm0.2^{\circ} , 28.41 ± 0.2 ∘ 28.41\pm0.2^{\circ} , 28.90 ± 0.2 ∘ 28.90\pm0.2^{\circ} , 29.70 ± 0.2 ∘ 29.70\pm0.2^{\circ} , 30.21 ± 0.2 ∘ 30.21\pm0.2^{\circ} , 30.99 ± 0.2 ∘ 30.99\pm0.2^{\circ} ; the X-ray powder diffraction pattern of L-tartarate crystal form A further has one or more 2 θ 2\theta angles selected from the group consisting of: 8.90 ± 0.2 ∘ 8.90\pm0.2^{\circ} , 9.35 ± 0.2 ∘ 9.35\pm0.2^{\circ} , 11.05 ± 0.2 ∘ 11.05\pm0.2^{\circ} , 12.54 ± 0.2 ∘ 12.54\pm0.2^{\circ} , 12.90 ± 0.2 ∘ 12.90\pm0.2^{\circ} , 14.35 ± 0.2 ∘ 14.35\pm0.2^{\circ} , 14.64 ± 0.2 ∘ 14.64\pm0.2^{\circ} , 18.70 ± 0.2 ∘ 18.70\pm0.2^{\circ} , 19.45 ± 0.2 ∘ 19.45\pm0.2^{\circ} , 19.74 ± 0.2 ∘ 19.74\pm0.2^{\circ} , 20.38 ± 0.2 ∘ 20.38\pm0.2^{\circ} , 21.45 ± 0.2 ∘ 21.45\pm0.2^{\circ} , 21.94 ± 0.2 ∘ 21.94\pm0.2^{\circ} , 22.88 ± 0.2 ∘ 22.88\pm0.2^{\circ} , 23.80 ± 0.2 ∘ 23.80\pm0.2^{\circ} , 25.01 ± 0.2 ∘ 25.01\pm0.2^{\circ} , 25.77 ± 0.2 ∘ 25.77\pm0.2^{\circ} , 27.33 ± 0.2 ∘ 27.33\pm0.2^{\circ} , 27.80 ± 0.2 ∘ 27.80\pm0.2^{\circ} , 28.65 ± 0.2 ∘ 28.65\pm0.2^{\circ} , 29.41 ± 0.2 ∘ 29.41\pm0.2^{\circ} , 30.00 ± 0.2 ∘ 30.00\pm0.2^{\circ} , 31.09 ± 0.2 ∘ 31.09\pm0.2^{\circ} ; the X-ray powder diffraction pattern of the hippurate crystal form A further has one or more 2θ angles selected from the group consisting of: 6.52±0.2°, 8.77±0.2°, 10.74±0.2°, 11.16 ± 0.2 ∘ 11.16\pm0.2^{\circ} , 14.18 ± 0.2 ∘ 14.18\pm0.2^{\circ} , 14.70 ± 0.2 ∘ 14.70\pm0.2^{\circ} , 15.62 ± 0.2 ∘ 15.62\pm0.2^{\circ} , 16.06 ± 0.2 ∘ 16.06\pm0.2^{\circ} , 16.78 ± 0.2 ∘ 16.78\pm0.2^{\circ} , 17.64 ± 0.2 ∘ 17.64\pm0.2^{\circ} , 20.42 ± 0.2 ∘ 20.42\pm0.2^{\circ} , 21.15 ± 0.2 ∘ 21.15\pm0.2^{\circ} , 21.29 ± 0.2 ∘ 21.29\pm0.2^{\circ} , 21.79 ± 0.2 ∘ 21.79\pm0.2^{\circ} , 23.03 ± 0.2 ∘ 23.03\pm0.2^{\circ} , 24.05 ± 0.2 ∘ 24.05\pm0.2^{\circ} , 24.42 ± 0.2 ∘ 24.42\pm0.2^{\circ} , 25.32 ± 0.2 ∘ 25.32\pm0.2^{\circ} , 26.45 ± 0.2 ∘ 26.45\pm0.2^{\circ} , 26.87 ± 0.2 ∘ 26.87\pm0.2^{\circ} , 28.85 ± 0.2 ∘ 28.85\pm0.2^{\circ} ; the X-ray powder diffraction pattern of the glutarate crystal form A further has one or more 20 angles selected from the group consisting of: 9.86 ± 0.2 ∘ 9.86\pm0.2^{\circ} , 10.97 ± 0.2 ∘ 10.97\pm0.2^{\circ} , 11.82 ± 0.2 ∘ 11.82\pm0.2^{\circ} , 12.29 ± 0.2 ∘ 12.29 \pm 0.2^{\circ} , 12.75 ± 0.2 ∘ 12.75 \pm 0.2^{\circ} , 13.19 ± 0.2 ∘ 13.19 \pm 0.2^{\circ} , 14.87 ± 0.2 ∘ 14.87 \pm 0.2^{\circ} , 15.10 ± 0.2 ∘ 15.10 \pm 0.2^{\circ} , 15.37 ± 0.2 ∘ 15.37 \pm 0.2^{\circ} , 16.33 ± 0.2 ∘ 16.33 \pm 0.2^{\circ} , 17.10 ± 0.2 ∘ 17.10\pm0.2^{\circ} , 18.35 ± 0.2 ∘ 18.35\pm0.2^{\circ} , 19.17 ± 0.2 ∘ 19.17\pm0.2^{\circ} , 19.75 ± 0.2 ∘ 19.75\pm0.2^{\circ} , 20.14 ± 0.2 ∘ 20.14\pm0.2^{\circ} , 20.70 ± 0.2 ∘ 20.70\pm0.2^{\circ} , 21.14 ± 0.2 ∘ 21.14\pm0.2^{\circ} , 22.23 ± 0.2 ∘ 22.23\pm0.2^{\circ} , 24.26 ± 0.2 ∘ 24.26\pm0.2^{\circ} , 24.86 ± 0.2 ∘ 24.86\pm0.2^{\circ} , 25.28 ± 0.2 ∘ 25.28\pm0.2^{\circ} , 29.92 ± 0.2 ∘ 29.92\pm0.2^{\circ} ; the X-ray powder diffraction pattern of the p-toluenesulfonate crystal form A further has one or more 20 angles selected from the group consisting of: 7.08 ± 0.2 ∘ 7.08\pm0.2^{\circ} , 8.00 ± 0.2 ∘ 8.00\pm0.2^{\circ} , 9.39 9.39 ± 0.2 ∘ \pm 0.2^{\circ} , 10.23 ± 0.2 ∘ 10.23 \pm 0.2^{\circ} , 13.36 ± 0.2 ∘ 13.36 \pm 0.2^{\circ} , 14.16 ± 0.2 ∘ 14.16 \pm 0.2^{\circ} , 14.81 ± 0.2 ∘ 14.81 \pm 0.2^{\circ} , 15.77 ± 0.2 ∘ 15.77 \pm 0.2^{\circ} , 16.21 ± 0.2 ∘ 16.21 \pm 0.2^{\circ} , 17.77 ± 0.2 ∘ 17.77\pm0.2^{\circ} , 18.10 ± 0.2 ∘ 18.10\pm0.2^{\circ} , 18.90 ± 0.2 ∘ 18.90\pm0.2^{\circ} , 20.91 ± 0.2 ∘ 20.91\pm0.2^{\circ} , 21.29 ± 0.2 ∘ 21.29\pm0.2^{\circ} , 22.49 ± 0.2 ∘ 22.49\pm0.2^{\circ} , 23.11 ± 0.2 ∘ 23.11\pm0.2^{\circ} , 24.41 ± 0.2 ∘ 24.41\pm0.2^{\circ} , 25.51 ± 0.2 ∘ 25.51\pm0.2^{\circ} , 26.77 ± 0.2 ∘ 26.77\pm0.2^{\circ} , 28.28 ± 0.2 ∘ 28.28\pm0.2^{\circ} , 28.81 ± 0.2 ∘ 28.81\pm0.2^{\circ} , 29.22 ± 0.2 ∘ 29.22\pm0.2^{\circ} , 29.95 ± 0.2 ∘ 29.95\pm0.2^{\circ} , 30.98 ± 0.2 ∘ 30.98\pm0.2^{\circ} , 35.22 ± 0.2 ∘ 35.22\pm0.2^{\circ} ; the X-ray powder diffraction pattern of the p-toluenesulfonate crystal form B further has one or more 2 θ 2\theta angles selected from the group consisting of: 8.27 ± 0.2 ∘ 8.27 \pm 0.2^{\circ} , 12.59 ± 0.2 ∘ 12.59 \pm 0.2^{\circ} , 13.69 ± 0.2 ∘ 13.69 \pm 0.2^{\circ} , 14.63 ± 0.2 ∘ 14.63 \pm 0.2^{\circ} , 16.15 ± 0.2 ∘ 16.15 \pm 0.2^{\circ} , 17.72 ± 0.2 ∘ 17.72 \pm 0.2^{\circ} , 18.68 ± 0.2 ∘ 18.68 \pm 0.2^{\circ} , 20.75 ± 0.2 ∘ 20.75 \pm 0.2^{\circ} , 21.05 ± 0.2 ∘ 21.05 \pm 0.2^{\circ} , 21.92 ± 0.2 ∘ 21.92\pm0.2^{\circ} , 22.45 ± 0.2 ∘ 22.45\pm0.2^{\circ} , 23.23 ± 0.2 ∘ 23.23\pm0.2^{\circ} , 23.91 ± 0.2 ∘ 23.91\pm0.2^{\circ} , 27.33 ± 0.2 ∘ 27.33\pm0.2^{\circ} , 29.25 ± 0.2 ∘ 29.25\pm0.2^{\circ} ; the X-ray powder diffraction pattern of the methanesulfonate crystal form A further comprises one or more 2 θ 2\theta angles selected from the group consisting of: 6.70 ± 0.2 ∘ 6.70\pm0.2^{\circ} , 9.10 ± 0.2 ∘ 9.10\pm0.2^{\circ} , 9.81 ± 0.2 ∘ 9.81 \pm 0.2^{\circ} , 10.16 ± 0.2 ∘ 10.16 \pm 0.2^{\circ} , 13.34 ± 0.2 ∘ 13.34 \pm 0.2^{\circ} , 13.87 ± 0.2 ∘ 13.87 \pm 0.2^{\circ} , 15.37 ± 0.2 ∘ 15.37 \pm 0.2^{\circ} , 15.79 ± 0.2 ∘ 15.79 \pm 0.2^{\circ} , 17.21 ± 0.2 ∘ 17.21 \pm 0.2^{\circ} , 18.75 ± 0.2 ∘ 18.75\pm0.2^{\circ} , 21.16 ± 0.2 ∘ 21.16\pm0.2^{\circ} , 22.09 ± 0.2 ∘ 22.09\pm0.2^{\circ} , 23.31 ± 0.2 ∘ 23.31\pm0.2^{\circ} , 23.86 ± 0.2 ∘ 23.86\pm0.2^{\circ} , 24.30 ± 0.2 ∘ 24.30\pm0.2^{\circ} , 27.18 ± 0.2 ∘ 27.18\pm0.2^{\circ} , 28.04 ± 0.2 ∘ , 28.83 ± 0.2 ∘ ; 28.04\pm0.2^{\circ}, 28.83\pm0.2^{\circ}; the hydrochloride crystal form C1 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form C1 also has one or more 2θ angles selected from the group consisting of: 7.47±0.2°, 9.63±0.2°, 11.46 ± 0.2 ∘ 11.46\pm0.2^{\circ} , 12.25 ± 0.2 ∘ 12.25\pm0.2^{\circ} , 13.18 ± 0.2 ∘ 13.18\pm0.2^{\circ} , 13.51 ± 0.2 ∘ 13.51\pm0.2^{\circ} , 14.96 ± 0.2 ∘ 14.96\pm0.2^{\circ} , 15.46 ± 0.2 ∘ 15.46\pm0.2^{\circ} , 16.79 ± 0.2 ∘ 16.79\pm0.2^{\circ} , 17.04 ± 0.2 ∘ 17.04 \pm 0.2^{\circ} , 17.31 ± 0.2 ∘ 17.31\pm0.2^{\circ} , 17.72 ± 0.2 ∘ 17.72\pm0.2^{\circ} , 18.56 ± 0.2 ∘ 18.56\pm0.2^{\circ} , 19.34 ± 0.2 ∘ 19.34\pm0.2^{\circ} , 20.01 ± 0.2 ∘ 20.01\pm0.2^{\circ} , 20.41 ± 0.2 ∘ 20.41\pm0.2^{\circ} , 20.76 ± 0.2 ∘ 20.76\pm0.2^{\circ} , 22.60 ± 0.2 ∘ 22.60\pm0.2^{\circ} , 23.09 ± 0.2 ∘ 23.09\pm0.2^{\circ} , 23.80 ± 0.2 ∘ 23.80\pm0.2^{\circ} , 24.36 ± 0.2 ∘ 24.36\pm0.2^{\circ} , 25.63 ± 0.2 ∘ 25.63\pm0.2^{\circ} , 26.47 ± 0.2 ∘ 26.47\pm0.2^{\circ} , 27.51 27.51 ± 0.2 ∘ \pm 0.2^{\circ} , 29.09 ± 0.2 ∘ \pm 0.2^{\circ} , 30.76 ± 0.2 ∘ \pm 0.2^{\circ} , 31.99 ± 0.2 ∘ \pm 0.2^{\circ} , 36.24 ± 0.2 ∘ \pm 0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form C1 has the onsets of the endothermic peaks at 39.76°C ± \pm 2°C and 153.80°C ± \pm 2°C; c. the thermogravimetric analysis curve of the hydrochloride crystal form C1 has three weight loss steps at 26.03 ∘ C ± 2 ∘ C 26.03^{\circ}\text{C} \pm 2^{\circ}\text{C} , 100.00 ∘ C ± 2 ∘ C 100.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 214.75 ∘ C ± 2 ∘ C 214.75^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form C2 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form C2 further has one or more 2θ angles selected from the group consisting of: 7.56±0.2°, 9.65±0.2°, 11.48 ± 0.2 ∘ 11.48\pm0.2^{\circ} , 12.32 ± 0.2 ∘ 12.32\pm0.2^{\circ} , 13.21 ± 0.2 ∘ 13.21\pm0.2^{\circ} , 13.63 ± 0.2 ∘ 13.63\pm0.2^{\circ} , 15.10 ± 0.2 ∘ 15.10\pm0.2^{\circ} , 15.56 ± 0.2 ∘ 15.56\pm0.2^{\circ} , 16.86 ± 0.2 ∘ 16.86\pm0.2^{\circ} , 17.16 ± 0.2 ∘ 17.16 \pm 0.2^{\circ} , 17.41 ± 0.2 ∘ 17.41\pm0.2^{\circ} , 17.77 ± 0.2 ∘ 17.77\pm0.2^{\circ} , 18.58 ± 0.2 ∘ 18.58\pm0.2^{\circ} , 19.36 ± 0.2 ∘ 19.36\pm0.2^{\circ} , 20.32 ± 0.2 ∘ 20.32\pm0.2^{\circ} , 20.91 ± 0.2 ∘ 20.91\pm0.2^{\circ} , 22.71 ± 0.2 ∘ 22.71\pm0.2^{\circ} , 23.21 ± 0.2 ∘ 23.21\pm0.2^{\circ} , 23.80 ± 0.2 ∘ 23.80\pm0.2^{\circ} , 24.35 ± 0.2 ∘ 24.35\pm0.2^{\circ} , 25.71 ± 0.2 ∘ 25.71\pm0.2^{\circ} , 26.56 ± 0.2 ∘ 26.56\pm0.2^{\circ} , 27.53 ± 0.2 ∘ 27.53\pm0.2^{\circ} , 27.80 ± 0.2 ∘ 27.80\pm0.2^{\circ} , 28.20 ± 0.2 ∘ 28.20\pm0.2^{\circ} , 29.15 ± 0.2 ∘ 29.15\pm0.2^{\circ} , 30.74 ± 0.2 ∘ 30.74\pm0.2^{\circ} , 32.06 ± 0.2 ∘ 32.06\pm0.2^{\circ} , 36.30 ± 0.2 ∘ 36.30\pm0.2^{\circ} , 38.22 ± 0.2 ∘ 38.22\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form C2 has the onsets of the endothermic peaks at 33.27 ∘ C ± 2 ∘ C 33.27^{\circ}C \pm 2^{\circ}C and 155.72 ∘ C ± 2 ∘ C 155.72^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form C2 has three weight loss steps at 28.19 ∘ C ± 2 ∘ C 28.19^{\circ}\text{C} \pm 2^{\circ}\text{C} , 115.00 ∘ C ± 2 ∘ C 115.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.45°C ± \pm 2°C; the hydrochloride crystal form D further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form D also has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2 θ 2\theta angles selected from the group consisting of: 6.60 ± 0.2 ∘ 6.60\pm0.2^{\circ} , 7.26 ± 0.2 ∘ 7.26\pm0.2^{\circ} , 7.79 ± 0.2 ∘ 7.79\pm0.2^{\circ} , 8.48 ± 0.2 ∘ 8.48\pm0.2^{\circ} , 9.84 ± 0.2 ∘ 9.84\pm0.2^{\circ} , 11.18 ± 0.2 ∘ 11.18\pm0.2^{\circ} , 13.31 ± 0.2 ∘ 13.31\pm0.2^{\circ} , 13.89 ± 0.2 ∘ 13.89\pm0.2^{\circ} , 14.64 ± 0.2 ∘ 14.64\pm0.2^{\circ} , 14.98 ± 0.2 ∘ 14.98\pm0.2^{\circ} , 15.23 ± 0.2 ∘ 15.23\pm0.2^{\circ} , 16.27 ± 0.2 ∘ 16.27\pm0.2^{\circ} , 17.04 ± 0.2 ∘ 17.04\pm0.2^{\circ} , 18.21 ± 0.2 ∘ 18.21\pm0.2^{\circ} , 19.33 ± 0.2 ∘ 19.33\pm0.2^{\circ} , 21.23 ± 0.2 ∘ 21.23\pm0.2^{\circ} , 21.80 ± 0.2 ∘ 21.80\pm0.2^{\circ} , 23.49 ± 0.2 ∘ 23.49\pm0.2^{\circ} , 24.79 ± 0.2 ∘ 24.79\pm0.2^{\circ} , 28.43 ± 0.2 ∘ 28.43\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form D has the onsets of the endothermic peaks at 55.20 ∘ C ± 2 ∘ C 55.20^{\circ}\text{C} \pm 2^{\circ}\text{C} and 164.37 ∘ C ± 2 ∘ C 164.37^{\circ}\text{C} \pm 2^{\circ}\text{C} , c. the thermogravimetric analysis curve of the hydrochloride crystal form D has two weight loss steps at 36.24 ∘ C ± 2 ∘ C 36.24^{\circ}\text{C} \pm 2^{\circ}\text{C} and 110.00 ∘ C ± 2 ∘ C 110.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 211.35 ∘ C 211.35^{\circ}\text{C} ± 2 \pm 2 °C; the hydrochloride crystal form E1 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form E1 further has one or more 20 angles selected from the group consisting of: 6.15 ± 0.2 ∘ 6.15\pm0.2^{\circ} , 7.66 ± 0.2 ∘ 7.66\pm0.2^{\circ} , 8.41 ± 0.2 ∘ 8.41\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 9.49 ± 0.2 ∘ 9.49 \pm 0.2^{\circ} , 9.91 ± 0.2 ∘ 9.91 \pm 0.2^{\circ} , 10.88 ± 0.2 ∘ 10.88 \pm 0.2^{\circ} , 11.42 ± 0.2 ∘ 11.42 \pm 0.2^{\circ} , 13.06 ± 0.2 ∘ 13.06 \pm 0.2^{\circ} , 13.66 ± 0.2 ∘ 13.66 \pm 0.2^{\circ} , 14.69 ± 0.2 ∘ 14.69 \pm 0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 15.32 ± 0.2 ∘ 15.32 \pm 0.2^{\circ} , 15.52 ± 0.2 ∘ 15.52 \pm 0.2^{\circ} , 15.88 ± 0.2 ∘ 15.88 \pm 0.2^{\circ} , 16.25 ± 0.2 ∘ 16.25 \pm 0.2^{\circ} , 16.81 ± 0.2 ∘ 16.81 \pm 0.2^{\circ} , 17.35 ± 0.2 ∘ 17.35 \pm 0.2^{\circ} , 18.37 ± 0.2 ∘ 18.37\pm0.2^{\circ} , 19.01 ± 0.2 ∘ 19.01\pm0.2^{\circ} , 19.75 ± 0.2 ∘ 19.75\pm0.2^{\circ} , 21.15 ± 0.2 ∘ 21.15\pm0.2^{\circ} , 21.51 ± 0.2 ∘ 21.51\pm0.2^{\circ} , 21.81 ± 0.2 ∘ 21.81\pm0.2^{\circ} , 22.50 ± 0.2 ∘ 22.50\pm0.2^{\circ} , 22.87 ± 0.2 ∘ 22.87\pm0.2^{\circ} , 23.56 ± 0.2 ∘ 23.56\pm0.2^{\circ} , 24.95 ± 0.2 ∘ 24.95\pm0.2^{\circ} , 25.18 ± 0.2 ∘ 25.18\pm0.2^{\circ} , 25.63 ± 0.2 ∘ 25.63\pm0.2^{\circ} , 26.71 ± 0.2 ∘ 26.71\pm0.2^{\circ} , 27.10 ± 0.2 ∘ 27.10\pm0.2^{\circ} , 27.91 ± 0.2 ∘ 27.91\pm0.2^{\circ} , 28.47 ± 0.2 ∘ 28.47\pm0.2^{\circ} , 29.30 ± 0.2 ∘ 29.30\pm0.2^{\circ} , 29.81 ± 0.2 ∘ 29.81\pm0.2^{\circ} , 30.12 ± 0.2 ∘ 30.12\pm0.2^{\circ} , 32.93 ± 0.2 ∘ 32.93\pm0.2^{\circ} , 34.96 ± 0.2 ∘ 34.96\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form E1 has the onsets of the endothermic peaks at 13.36 ∘ C ± 2 ∘ C 13.36^{\circ}C \pm 2^{\circ}C and 174.06 ∘ C ± 2 ∘ C 174.06^{\circ}C \pm 2^{\circ}C ; c. The thermogravimetric analysis curve of the hydrochloride crystal form E1 has three weight loss steps at 25.81 ∘ 25.81^{\circ} C ± 2 ∘ \pm 2^{\circ} C, 120.00 ∘ 120.00^{\circ} C ± 2 ∘ \pm 2^{\circ} C, and 160.00 ∘ 160.00^{\circ} C ± 2 ∘ \pm 2^{\circ} C, and decomposition begins at 211.29 ∘ C ± 2 ∘ C 211.29^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form E2 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form E2 also has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 20 angles selected from the group consisting of: 9.51 ± 0.2 ∘ 9.51\pm0.2^{\circ} , 10.90 ± 0.2 ∘ 10.90\pm0.2^{\circ} , 11.49 ± 0.2 ∘ 11.49\pm0.2^{\circ} , 13.10 ± 0.2 ∘ 13.10\pm0.2^{\circ} , 13.64 ± 0.2 ∘ 13.64\pm0.2^{\circ} , 14.76 ± 0.2 ∘ 14.76\pm0.2^{\circ} , 15.39 ± 0.2 ∘ 15.39\pm0.2^{\circ} , 15.75 ± 0.2 ∘ 15.75\pm0.2^{\circ} , 16.30 ± 0.2 ∘ 16.30\pm0.2^{\circ} , 16.93 ± 0.2 ∘ 16.93\pm0.2^{\circ} , 19.01 ± 0.2 ∘ 19.01\pm0.2^{\circ} , 20.69 ± 0.2 ∘ 20.69\pm0.2^{\circ} , 21.54 ± 0.2 ∘ 21.54\pm0.2^{\circ} , 21.84 ± 0.2 ∘ 21.84\pm0.2^{\circ} , 22.19 ± 0.2 ∘ 22.19\pm0.2^{\circ} , 22.57 ± 0.2 ∘ 22.57\pm0.2^{\circ} , 23.01 ± 0.2 ∘ 23.01\pm0.2^{\circ} , 23.63 ± 0.2 ∘ 23.63\pm0.2^{\circ} , 24.96 ± 0.2 ∘ 24.96\pm0.2^{\circ} , 25.90 ± 0.2 ∘ 25.90\pm0.2^{\circ} , 26.32 ± 0.2 ∘ 26.32\pm0.2^{\circ} , 26.78 ± 0.2 ∘ 26.78\pm0.2^{\circ} , 27.19 ± 0.2 ∘ 27.19\pm0.2^{\circ} , 27.48 ± 0.2 ∘ 27.48\pm0.2^{\circ} , 27.94 ± 0.2 ∘ 27.94\pm0.2^{\circ} , 28.68 ± 0.2 ∘ 28.68\pm0.2^{\circ} , 29.07 ± 0.2 ∘ 29.07\pm0.2^{\circ} , 29.50 ± 0.2 ∘ 29.50\pm0.2^{\circ} , 29.91 ± 0.2 ∘ 29.91\pm0.2^{\circ} , 31.74 ± 0.2 ∘ 31.74\pm0.2^{\circ} , 32.96 ± 0.2 ∘ 32.96\pm0.2^{\circ} , 33.66 ± 0.2 ∘ 33.66\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form E2 has the onsets of the endothermic peaks at 14.99 ∘ C ± 2 ∘ C 14.99^{\circ}C \pm 2^{\circ}C and 174.19 ∘ C ± 2 ∘ C 174.19^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form E2 has three weight loss steps at 33.18 ∘ C ± 2 ∘ C 33.18^{\circ}\text{C} \pm 2^{\circ}\text{C} , 90.00 ∘ C ± 2 ∘ C 90.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 140.00 ∘ C ± 2 ∘ C 140.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 213.17 ∘ C ± 2 ∘ C 213.17^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form F further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form F also has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2 θ 2\theta angles selected from the group consisting of: 6.85 ± 0.2 ∘ 6.85\pm0.2^{\circ} , 10.21 ± 0.2 ∘ 10.21\pm0.2^{\circ} , 10.70 ± 0.2 ∘ 10.70\pm0.2^{\circ} , 14.80 ± 0.2 ∘ 14.80\pm0.2^{\circ} , 15.25 ± 0.2 ∘ 15.25\pm0.2^{\circ} , 16.60 ± 0.2 ∘ 16.60\pm0.2^{\circ} , 16.88 ± 0.2 ∘ 16.88\pm0.2^{\circ} , 17.84 ± 0.2 ∘ 17.84 \pm 0.2^{\circ} , 19.00 ± 0.2 ∘ 19.00 \pm 0.2^{\circ} , 19.16 ± 0.2 ∘ 19.16 \pm 0.2^{\circ} , 19.84 ± 0.2 ∘ 19.84 \pm 0.2^{\circ} , 20.09 ± 0.2 ∘ 20.09 \pm 0.2^{\circ} , 20.34 ± 0.2 ∘ 20.34 \pm 0.2^{\circ} , 21.51 ± 0.2 ∘ 21.51 \pm 0.2^{\circ} , 22.35 ± 0.2 ∘ 22.35\pm0.2^{\circ} , 23.22 ± 0.2 ∘ 23.22\pm0.2^{\circ} , 23.86 ± 0.2 ∘ 23.86\pm0.2^{\circ} , 25.06 ± 0.2 ∘ 25.06\pm0.2^{\circ} , 25.31 ± 0.2 ∘ 25.31\pm0.2^{\circ} , 25.63 ± 0.2 ∘ 25.63\pm0.2^{\circ} , 26.68 ± 0.2 ∘ 26.68\pm0.2^{\circ} , 28.10 28.10 ± 0.2 \pm 0.2 °, 28.87 ± 0.2 \pm 0.2 °, 30.53 ± 0.2 \pm 0.2 °, 32.45 ± 0.2 \pm 0.2 °, 33.59 ± 0.2 \pm 0.2 °; b. the differential scanning calorimetry curve of the hydrochloride crystal form F has the onsets of the endothermic peaks at 36.03 ∘ C ± 2 ∘ C 36.03^{\circ}C \pm 2^{\circ}C and 172.45 ∘ C ± 2 ∘ C 172.45^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form F has three weight loss steps at 33.35 ∘ C ± 2 ∘ C 33.35^{\circ}\text{C} \pm 2^{\circ}\text{C} , 100.00 ∘ C ± 2 ∘ C 100.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.66 ∘ C ± 2 ∘ C 212.66^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form G further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form G also has one or more 20 angles selected from the group consisting of: 5.83 ± 0.2 ∘ 5.83\pm0.2^{\circ} , 7.18 ± 0.2 ∘ 7.18\pm0.2^{\circ} , 9.97 ± 0.2 ∘ 9.97\pm0.2^{\circ} , 11.63 ± 0.2 ∘ 11.63 \pm 0.2^{\circ} , 12.00 ± 0.2 ∘ 12.00 \pm 0.2^{\circ} , 12.35 ± 0.2 ∘ 12.35 \pm 0.2^{\circ} , 13.26 ± 0.2 ∘ 13.26 \pm 0.2^{\circ} , 13.58 ± 0.2 ∘ 13.58 \pm 0.2^{\circ} , 14.17 ± 0.2 ∘ 14.17 \pm 0.2^{\circ} , 14.60 ± 0.2 ∘ 14.60 \pm 0.2^{\circ} , 17.64 ± 0.2 ∘ 17.64\pm0.2^{\circ} , 18.37 ± 0.2 ∘ 18.37\pm0.2^{\circ} , 18.81 ± 0.2 ∘ 18.81\pm0.2^{\circ} , 19.14 ± 0.2 ∘ 19.14\pm0.2^{\circ} , 19.80 ± 0.2 ∘ 19.80\pm0.2^{\circ} , 20.27 ± 0.2 ∘ 20.27\pm0.2^{\circ} , 20.48 ± 0.2 ∘ 20.48\pm0.2^{\circ} , 21.35 ± 0.2 ∘ 21.35\pm0.2^{\circ} , 21.82 ± 0.2 ∘ 21.82\pm0.2^{\circ} , 22.65 ± 0.2 ∘ 22.65\pm0.2^{\circ} , 23.35 ± 0.2 ∘ 23.35\pm0.2^{\circ} , 24.43 ± 0.2 ∘ 24.43\pm0.2^{\circ} , 25.47 ± 0.2 ∘ 25.47\pm0.2^{\circ} , 26.24 ± 0.2 ∘ 26.24\pm0.2^{\circ} , 26.54 ± 0.2 ∘ 26.54\pm0.2^{\circ} , 26.84 ± 0.2 ∘ 26.84\pm0.2^{\circ} , 27.92 ± 0.2 ∘ 27.92\pm0.2^{\circ} , 28.94 ± 0.2 ∘ 28.94\pm0.2^{\circ} , 29.31 ± 0.2 ∘ 29.31\pm0.2^{\circ} , 30.18 ± 0.2 ∘ 30.18\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form G has the onsets of the endothermic peaks at 59.42 ∘ C ± 2 ∘ C 59.42^{\circ}C \pm 2^{\circ}C , 151.02 ∘ C ± 2 ∘ C 151.02^{\circ}C \pm 2^{\circ}C , and 166.01 ∘ C ± 2 ∘ C 166.01^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form G has three weight loss steps at 26.28 ∘ C ± 2 ∘ C 26.28^{\circ}\text{C} \pm 2^{\circ}\text{C} , 120.00 ∘ C ± 2 ∘ C 120.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} ; the hydrochloride crystal form H further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form H further has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2θ angles selected from the group consisting of: 7.16 ± 0.2 ∘ 7.16\pm0.2^{\circ} , 10.02 ± 0.2 ∘ 10.02\pm0.2^{\circ} , 11.64 ± 0.2 ∘ 11.64\pm0.2^{\circ} , 12.35 ± 0.2 ∘ 12.35\pm0.2^{\circ} , 13.23 ± 0.2 ∘ 13.23\pm0.2^{\circ} , 13.59 ± 0.2 ∘ 13.59\pm0.2^{\circ} , 14.58 ± 0.2 ∘ 14.58\pm0.2^{\circ} , 15.51 ± 0.2 15.51 \pm 0.2 °, 15.97 ± 0.2 15.97 \pm 0.2 °, 17.63 ± 0.2 17.63 \pm 0.2 °, 18.62 ± 0.2 18.62 \pm 0.2 °, 19.11 ± 0.2 19.11 \pm 0.2 °, 20.23 ± 0.2 20.23 \pm 0.2 °, 20.54 ± 0.2 20.54 \pm 0.2 °, 21.40 ± 0.2 ∘ 21.40\pm0.2^{\circ} , 22.07 ± 0.2 ∘ 22.07\pm0.2^{\circ} , 22.62 ± 0.2 ∘ 22.62\pm0.2^{\circ} , 22.78 ± 0.2 ∘ 22.78\pm0.2^{\circ} , 23.36 ± 0.2 ∘ 23.36\pm0.2^{\circ} , 24.73 ± 0.2 ∘ 24.73\pm0.2^{\circ} , 24.98 ± 0.2 ∘ 24.98\pm0.2^{\circ} , 26.23 ± 0.2 ∘ 26.23\pm0.2^{\circ} , 26.57 ± 0.2 ∘ 26.57\pm0.2^{\circ} , 26.91 ± 0.2 ∘ 26.91\pm0.2^{\circ} , 27.88 ± 0.2 ∘ 27.88\pm0.2^{\circ} , 29.01 ± 0.2 ∘ 29.01\pm0.2^{\circ} , 29.30 ± 0.2 ∘ 29.30\pm0.2^{\circ} , 29.61 ± 0.2 ∘ 29.61\pm0.2^{\circ} , 30.21 ± 0.2 ∘ 30.21\pm0.2^{\circ} , 31.21 ± 0.2 ∘ 31.21\pm0.2^{\circ} , 32.12 ± 0.2 ∘ 32.12\pm0.2^{\circ} , 34.66 ± 0.2 ∘ 34.66\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form H has the onsets of the endothermic peaks at 51.49 ∘ C ± 2 ∘ C 51.49^{\circ}C \pm 2^{\circ}C and 153.61 ∘ C ± 2 ∘ C 153.61^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form H has three weight loss steps at 26.12 ∘ C ± 2 ∘ C 26.12^{\circ}\text{C} \pm 2^{\circ}\text{C} , 110.00 ∘ C ± 2 ∘ C 110.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 211.73 ∘ C ± 2 ∘ C 211.73^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form I further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form I also has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2 θ 2\theta angles selected from the group consisting of: 9.50 ± 0.2 ∘ 9.50\pm0.2^{\circ} , 12.31 ± 0.2 ∘ 12.31\pm0.2^{\circ} , 12.54 ± 0.2 ∘ 12.54\pm0.2^{\circ} , 14.05 ± 0.2 ∘ 14.05\pm0.2^{\circ} , 14.96 ± 0.2 ∘ 14.96\pm0.2^{\circ} , 15.38 ± 0.2 ∘ 15.38\pm0.2^{\circ} , 17.18 ± 0.2 ∘ 17.18\pm0.2^{\circ} , 17.92 ± 0.2 ∘ 17.92 \pm 0.2^{\circ} , 19.03 ± 0.2 ∘ 19.03 \pm 0.2^{\circ} , 19.74 ± 0.2 ∘ 19.74\pm0.2^{\circ} , 19.99 ± 0.2 ∘ 19.99\pm0.2^{\circ} , 20.96 ± 0.2 ∘ 20.96\pm0.2^{\circ} , 21.62 ± 0.2 ∘ 21.62\pm0.2^{\circ} , 21.99 ± 0.2 ∘ 21.99\pm0.2^{\circ} , 22.98 ± 0.2 ∘ 22.98\pm0.2^{\circ} , 23.52 ± 0.2 ∘ 23.52\pm0.2^{\circ} , 23.80 ± 0.2 ∘ 23.80\pm0.2^{\circ} , 24.38 ± 0.2 ∘ 24.38\pm0.2^{\circ} , 25.92 ± 0.2 ∘ 25.92\pm0.2^{\circ} , 26.81 ± 0.2 ∘ 26.81\pm0.2^{\circ} , 27.21 ± 0.2 ∘ 27.21\pm0.2^{\circ} , 27.60 ± 0.2 ∘ 27.60\pm0.2^{\circ} , 27.78 ± 0.2 ∘ 27.78\pm0.2^{\circ} , 28.26 ± 0.2 ∘ 28.26\pm0.2^{\circ} , 28.74 ± 0.2 ∘ 28.74\pm0.2^{\circ} , 30.07 ± 0.2 ∘ 30.07\pm0.2^{\circ} , 31.00 ± 0.2 ∘ 31.00\pm0.2^{\circ} , 32.69 ± 0.2 ∘ 32.69\pm0.2^{\circ} , 34.02 ± 0.2 ∘ 34.02\pm0.2^{\circ} , 34.83 ± 0.2 ∘ 34.83\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form I has the onsets of the endothermic peaks at 18.15 ∘ C ± 2 ∘ C 18.15^{\circ}C \pm 2^{\circ}C and 194.49 ∘ C ± 2 ∘ C 194.49^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form I has three weight loss steps at 28.31 ∘ C ± 2 ∘ C 28.31^{\circ}\text{C} \pm 2^{\circ}\text{C} , 70.00 ∘ C ± 2 ∘ C 70.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 173.00 ∘ C ± 2 ∘ C 173.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 215.51 ∘ C ± 2 ∘ C 215.51^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form J1 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form J1 also has one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) 2 θ 2\theta angles selected from the group consisting of: 7.82 ± 0.2 ∘ 7.82\pm0.2^{\circ} , 7.95 ± 0.2 ∘ 7.95\pm0.2^{\circ} , 10.08 ± 0.2 ∘ 10.08\pm0.2^{\circ} , 11.69 ± 0.2 ∘ 11.69\pm0.2^{\circ} , 12.30 ± 0.2 ∘ 12.30\pm0.2^{\circ} , 12.60 ± 0.2 ∘ 12.60\pm0.2^{\circ} , 13.60 ± 0.2 ∘ 13.60\pm0.2^{\circ} , 15.98 ± 0.2 ∘ 15.98\pm0.2^{\circ} ± 0.2 ∘ \pm 0.2^{\circ} , 16.25 ± 0.2 ∘ 16.25 \pm 0.2^{\circ} , 18.05 ± 0.2 ∘ 18.05 \pm 0.2^{\circ} , 18.60 ± 0.2 ∘ 18.60 \pm 0.2^{\circ} , 18.79 ± 0.2 ∘ 18.79 \pm 0.2^{\circ} , 19.49 ± 0.2 ∘ 19.49 \pm 0.2^{\circ} , 20.82 ± 0.2 ∘ 20.82 \pm 0.2^{\circ} , 21.55 ± 0.2 ∘ 21.55 \pm 0.2^{\circ} , 21.70 ± 0.2 ∘ 21.70\pm0.2^{\circ} , 22.06 ± 0.2 ∘ 22.06\pm0.2^{\circ} , 22.88 ± 0.2 ∘ 22.88\pm0.2^{\circ} , 23.69 ± 0.2 ∘ 23.69\pm0.2^{\circ} , 24.92 ± 0.2 ∘ 24.92\pm0.2^{\circ} , 25.13 ± 0.2 ∘ 25.13\pm0.2^{\circ} , 26.19 ± 0.2 ∘ 26.19\pm0.2^{\circ} , 26.57 ± 0.2 ∘ 26.57\pm0.2^{\circ} 0.2 ∘ 0.2^{\circ} , 29.07 ± 0.2 ∘ 29.07 \pm 0.2^{\circ} , 30.16 ± 0.2 ∘ 30.16 \pm 0.2^{\circ} , 31.85 ± 0.2 ∘ 31.85 \pm 0.2^{\circ} , 32.80 ± 0.2 ∘ 32.80 \pm 0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form J1 has the onsets of the endothermic peaks at 70.82 ∘ C ± 2 ∘ C 70.82^{\circ}C \pm 2^{\circ}C and 165.48 ∘ C ± 2 ∘ C 165.48^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form J1 has two weight loss steps at 33.94 ∘ C ± 2 ∘ C 33.94^{\circ}\text{C} \pm 2^{\circ}\text{C} and 110.00 ∘ C ± 2 ∘ C 110.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.96 ∘ C 212.96^{\circ}\text{C} ± 2 \pm 2 °C; the hydrochloride crystal form J2 further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form J2 also has one or more 20 angles selected from the group consisting of: 6.78 ± 0.2 ∘ 6.78\pm0.2^{\circ} , 7.96 ± 0.2 ∘ 7.96\pm0.2^{\circ} , 8.31 ± 0.2 ∘ 8.31\pm0.2^{\circ} , 11.59 ± 0.2 ∘ 11.59 \pm 0.2^{\circ} , 12.24 ± 0.2 ∘ 12.24 \pm 0.2^{\circ} , 13.56 ± 0.2 ∘ 13.56 \pm 0.2^{\circ} , 16.44 ± 0.2 ∘ 16.44 \pm 0.2^{\circ} , 16.63 ± 0.2 ∘ 16.63 \pm 0.2^{\circ} , 17.45 ± 0.2 ∘ 17.45 \pm 0.2^{\circ} , 18.12 ± 0.2 ∘ 18.12 \pm 0.2^{\circ} , 19.51 ± 0.2 ∘ 19.51\pm0.2^{\circ} , 20.12 ± 0.2 ∘ 20.12\pm0.2^{\circ} , 20.35 ± 0.2 ∘ 20.35\pm0.2^{\circ} , 20.49 ± 0.2 ∘ 20.49\pm0.2^{\circ} , 21.28 ± 0.2 ∘ 21.28\pm0.2^{\circ} , 21.46 ± 0.2 ∘ 21.46\pm0.2^{\circ} , 22.75 ± 0.2 ∘ 22.75\pm0.2^{\circ} , 23.27 ± 0.2 ∘ 23.27\pm0.2^{\circ} , 24.09 ± 0.2 ∘ 24.09\pm0.2^{\circ} , 24.86 ± 0.2 ∘ 24.86\pm0.2^{\circ} , 24.99 ± 0.2 ∘ 24.99\pm0.2^{\circ} , 25.37 ± 0.2 ∘ 25.37\pm0.2^{\circ} , 25.65 ± 0.2 ∘ 25.65\pm0.2^{\circ} , 26.54 ± 0.2 ∘ 26.54\pm0.2^{\circ} , 27.62 ± 0.2 ∘ 27.62\pm0.2^{\circ} , 28.61 ± 0.2 ∘ 28.61\pm0.2^{\circ} , 29.00 ± 0.2 ∘ 29.00\pm0.2^{\circ} , 30.43 ± 0.2 ∘ 30.43\pm0.2^{\circ} , 32.10 ± 0.2 ∘ 32.10\pm0.2^{\circ} , 33.01 ± 0.2 ∘ 33.01\pm0.2^{\circ} , 36.96 ± 0.2 ∘ 36.96\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of hydrochloride crystal form J2 has the onsets of the endothermic peaks at 77.60 ∘ C ± 2 ∘ C 77.60^{\circ}\text{C} \pm 2^{\circ}\text{C} and 163.47 ∘ C ± 2 ∘ C 163.47^{\circ}\text{C} \pm 2^{\circ}\text{C} ; c. the thermogravimetric analysis curve of the hydrochloride crystal form J2 has two weight loss steps at 28.73 ∘ C ± 2 ∘ C 28.73^{\circ}\text{C} \pm 2^{\circ}\text{C} and 120.00 ∘ C ± 2 ∘ C 120.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 211.78 ∘ C 211.78^{\circ}\text{C} ± 2 \pm 2 °C; the hydrochloride crystal form K further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form K also has one or more 20 angles selected from the group consisting of: 6.79 ± 0.2 ∘ 6.79\pm0.2^{\circ} , 7.83 ± 0.2 ∘ 7.83\pm0.2^{\circ} , 8.04 ± 0.2 ∘ 8.04\pm0.2^{\circ} , 10.00 ± 0.2 10.00 \pm 0.2 °, 10.74 ± 0.2 10.74 \pm 0.2 °, 11.61 ± 0.2 11.61 \pm 0.2 °, 12.25 ± 0.2 12.25 \pm 0.2 °, 12.64 ± 0.2 12.64 \pm 0.2 °, 13.57 ± 0.2 13.57 \pm 0.2 °, 18.05 ± 0.2 18.05 \pm 0.2 °, 18.63 ± 0.2 ∘ 18.63\pm0.2^{\circ} , 19.43 ± 0.2 ∘ 19.43\pm0.2^{\circ} , 20.15 ± 0.2 ∘ 20.15\pm0.2^{\circ} , 20.49 ± 0.2 ∘ 20.49\pm0.2^{\circ} , 20.64 ± 0.2 ∘ 20.64\pm0.2^{\circ} , 21.52 ± 0.2 ∘ 21.52\pm0.2^{\circ} , 21.72 ± 0.2 ∘ 21.72\pm0.2^{\circ} , 21.93 ± 0.2 ∘ 21.93\pm0.2^{\circ} , 23.27 ± 0.2 ∘ 23.27\pm0.2^{\circ} , 24.73 ± 0.2 ∘ 24.73\pm0.2^{\circ} , 25.19 ± 0.2 ∘ 25.19\pm0.2^{\circ} , 26.25 ± 0.2 ∘ 26.25\pm0.2^{\circ} , 26.57 ± 0.2 ∘ 26.57\pm0.2^{\circ} , 27.42 ± 0.2 ∘ 27.42\pm0.2^{\circ} , 28.02 ± 0.2 ∘ 28.02\pm0.2^{\circ} , 28.67 ± 0.2 ∘ 28.67\pm0.2^{\circ} , 29.13 ± 0.2 ∘ 29.13\pm0.2^{\circ} , 29.91 ± 0.2 ∘ 29.91\pm0.2^{\circ} , 32.56 ± 0.2 ∘ 32.56\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form K has the onsets of the endothermic peaks at 80.73 ∘ C ± 2 ∘ C 80.73^{\circ}C \pm 2^{\circ}C and 171.74 ∘ C ± 2 ∘ C 171.74^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form K has three weight loss steps at 33.39 ∘ C ± 2 ∘ C 33.39^{\circ}\text{C} \pm 2^{\circ}\text{C} , 125.00 ∘ C ± 2 ∘ C 125.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 155.00 ∘ C ± 2 ∘ C 155.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 211.42 ∘ C ± 2 ∘ C 211.42^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form L further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form L further has one or more 2 θ 2\theta angles selected from the group consisting of: 7.70 ± 0.2 ∘ 7.70\pm0.2^{\circ} , 8.15 ± 0.2 ∘ 8.15\pm0.2^{\circ} , 8.82 ± 0.2 ∘ 8.82\pm0.2^{\circ} , 9.85 ± 0.2 9.85 \pm 0.2 °, 11.25 ± 0.2 11.25 \pm 0.2 °, 12.72 ± 0.2 12.72 \pm 0.2 °, 13.59 ± 0.2 13.59 \pm 0.2 °, 14.68 ± 0.2 14.68 \pm 0.2 °, 15.07 ± 0.2 15.07 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 15.56 ± 0.2 15.56 \pm 0.2 °, 0.2 ∘ 0.2^{\circ} , 16.60 ± 0.2 ∘ 16.60\pm0.2^{\circ} , 17.56 ± 0.2 ∘ 17.56\pm0.2^{\circ} , 18.53 ± 0.2 ∘ 18.53\pm0.2^{\circ} , 18.98 ± 0.2 ∘ 18.98\pm0.2^{\circ} , 19.74 ± 0.2 ∘ 19.74\pm0.2^{\circ} , 20.29 ± 0.2 ∘ 20.29\pm0.2^{\circ} , 20.52 ± 0.2 ∘ 20.52\pm0.2^{\circ} , 21.30 ± 0.2 ∘ 21.30\pm0.2^{\circ} , 22.79 ± 0.2 ∘ 22.79\pm0.2^{\circ} , 24.38 ± 0.2 ∘ 24.38\pm0.2^{\circ} , 25.57 ± 0.2 ∘ 25.57\pm0.2^{\circ} , 26.21 ± 0.2 ∘ 26.21\pm0.2^{\circ} , 26.50 ± 0.2 ∘ 26.50\pm0.2^{\circ} , 26.97 ± 0.2 ∘ 26.97\pm0.2^{\circ} , 27.48 ± 0.2 ∘ 27.48\pm0.2^{\circ} , 28.17 ± 0.2 ∘ 28.17\pm0.2^{\circ} , 28.60 ± 0.2 ∘ 28.60\pm0.2^{\circ} , 29.54 ± 0.2 ∘ 29.54\pm0.2^{\circ} , 29.80 ± 0.2 ∘ 29.80\pm0.2^{\circ} , 31.17 ± 0.2 ∘ 31.17\pm0.2^{\circ} , 33.28 ± 0.2 ∘ 33.28\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form L has an onset of an endothermic peak at 180.17 ∘ C ± 2 ∘ C 180.17^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form L has two weight loss steps at 33.53 ∘ C ± 2 ∘ C 33.53^{\circ}\text{C} \pm 2^{\circ}\text{C} and 140.00 ∘ C ± 2 ∘ C 140.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.43 ∘ C 212.43^{\circ}\text{C} ± 2 \pm 2 °C; the hydrochloride crystal form M further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form M also has one or more 20 angles selected from the group consisting of: 6.84 ± 0.2 ∘ 6.84\pm0.2^{\circ} , 7.21 ± 0.2 ∘ 7.21\pm0.2^{\circ} , 8.92 ± 0.2 ∘ 8.92\pm0.2^{\circ} , 10.07 ± 0.2 10.07 \pm 0.2 °, 10.69 ± 0.2 10.69 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 11.24 ± 0.2 11.24 \pm 0.2 °, 13.23 ± 0.2 13.23 \pm 0.2 °, 14.90 ± 0.2 14.90 \pm 0.2 °, 15.59 ± 0.2 15.59 \pm 0.2 °, 10.69 ± 0.2 10.69 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 10.89 ± 0.2 10.89 \pm 0.2 °, 0.2 0.2 °, 16.74 ± 0.2 16.74 \pm 0.2 °, 17.67 ± 0.2 17.67 \pm 0.2 °, 18.29 ± 0.2 18.29 \pm 0.2 °, 18.94 ± 0.2 18.94 \pm 0.2 °, 19.46 ± 0.2 19.46 \pm 0.2 °, 19.71 ± 0.2 19.71 \pm 0.2 °, 19.96 ± 0.2 ∘ 19.96\pm0.2^{\circ} , 21.49 ± 0.2 ∘ 21.49\pm0.2^{\circ} , 21.83 ± 0.2 ∘ 21.83\pm0.2^{\circ} , 23.14 ± 0.2 ∘ 23.14\pm0.2^{\circ} , 23.54 ± 0.2 ∘ 23.54\pm0.2^{\circ} , 24.17 ± 0.2 ∘ 24.17\pm0.2^{\circ} , 25.17 ± 0.2 ∘ 25.17\pm0.2^{\circ} , 25.45 ± 0.2 ∘ 25.45\pm0.2^{\circ} , 26.10 ± 0.2 ∘ 26.10\pm0.2^{\circ} , 27.17 ± 0.2 ∘ 27.17\pm0.2^{\circ} , 27.61 ± 0.2 ∘ 27.61\pm0.2^{\circ} , 28.09 ± 0.2 ∘ 28.09\pm0.2^{\circ} , 28.88 ± 0.2 ∘ 28.88\pm0.2^{\circ} , 29.42 ± 0.2 ∘ 29.42\pm0.2^{\circ} , 30.12 ± 0.2 ∘ 30.12\pm0.2^{\circ} , 32.48 ± 0.2 ∘ 32.48\pm0.2^{\circ} , 35.22 ± 0.2 ∘ 35.22\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form M has the onsets of the endothermic peaks at 31.74 ∘ C ± 2 ∘ C 31.74^{\circ}C \pm 2^{\circ}C and 150.05 ∘ C ± 2 ∘ C 150.05^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form M has two weight loss steps at 32.98 ∘ C ± 2 ∘ C 32.98^{\circ}\text{C} \pm 2^{\circ}\text{C} and 115.00 ∘ C ± 2 ∘ C 115.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 215.09 ∘ C 215.09^{\circ}\text{C} ± 2 \pm 2 °C; the hydrochloride crystal form N further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form N also has one or more 20 angles selected from the group consisting of: 6.61 ± 0.2 ∘ 6.61\pm0.2^{\circ} , 7.80 ± 0.2 ∘ 7.80\pm0.2^{\circ} , 9.75 ± 0.2 ∘ 9.75\pm0.2^{\circ} , 11.19 ± 0.2 ∘ 11.19 \pm 0.2^{\circ} , 12.53 ± 0.2 ∘ 12.53 \pm 0.2^{\circ} , 13.17 ± 0.2 ∘ 13.17 \pm 0.2^{\circ} , 14.61 ± 0.2 ∘ 14.61 \pm 0.2^{\circ} , 15.24 ± 0.2 ∘ 15.24 \pm 0.2^{\circ} , 16.02 ± 0.2 ∘ 16.02 \pm 0.2^{\circ} , 18.51 ± 0.2 ∘ 18.51 \pm 0.2^{\circ} , 19.36 ± 0.2 ∘ 19.36 \pm 0.2^{\circ} , 21.57 ± 0.2 ∘ 21.57 \pm 0.2^{\circ} , 21.95 ± 0.2 ∘ 21.95 \pm 0.2^{\circ} , 23.47 ± 0.2 ∘ 23.47 \pm 0.2^{\circ} , 25.60 ± 0.2 ∘ 25.60 \pm 0.2^{\circ} , 27.32 ± 0.2 ∘ 27.32 \pm 0.2^{\circ} , 29.12 ± 0.2 ∘ 29.12 \pm 0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form N has the onsets of the endothermic peaks at 47.38 ∘ C ± 2 ∘ C 47.38^{\circ}C \pm 2^{\circ}C and 167.91 ∘ C ± 2 ∘ C 167.91^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form N has three weight loss steps at 33.22 ∘ C ± 2 ∘ C 33.22^{\circ}\text{C} \pm 2^{\circ}\text{C} , 75.00 ∘ C ± 2 ∘ C 75.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 150.00 ∘ C ± 2 ∘ C 150.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.57 ∘ C ± 2 ∘ C 212.57^{\circ}C \pm 2^{\circ}C ; the hydrochloride crystal form O further comprises one or more of the following characteristics: a. the X-ray powder diffraction pattern of the hydrochloride crystal form O also has one or more 2θ angles selected from the group consisting of: 6.14±0.2°, 8.39±0.2°, 9.90±0.2°, 11.28 ± 0.2 11.28 \pm 0.2 °, 13.19 ± 0.2 13.19 \pm 0.2 °, 13.54 ± 0.2 13.54 \pm 0.2 °, 14.40 ± 0.2 14.40 \pm 0.2 °, 15.33 ± 0.2 15.33 \pm 0.2 °, 15.87 ± 0.2 15.87 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 °, 15.87 ± 0.2 15.87 \pm 0.2 °, 15.87 ± 0.2 15.87 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 °, 16.79 ± 0.2 16.79 \pm 0.2 0.2 ∘ 0.2^{\circ} , 17.32 ± 0.2 ∘ 17.32\pm0.2^{\circ} , 19.03 ± 0.2 ∘ 19.03\pm0.2^{\circ} , 19.38 ± 0.2 ∘ 19.38\pm0.2^{\circ} , 19.84 ± 0.2 ∘ 19.84\pm0.2^{\circ} , 20.39 ± 0.2 ∘ 20.39\pm0.2^{\circ} , 21.14 ± 0.2 ∘ 21.14\pm0.2^{\circ} , 21.82 ± 0.2 ∘ 21.82\pm0.2^{\circ} , 22.51 ± 0.2 ∘ 22.51\pm0.2^{\circ} , 22.84 ± 0.2 ∘ 22.84\pm0.2^{\circ} , 23.77 ± 0.2 ∘ 23.77\pm0.2^{\circ} , 24.59 ± 0.2 ∘ 24.59\pm0.2^{\circ} , 25.28 ± 0.2 ∘ 25.28\pm0.2^{\circ} , 26.21 ± 0.2 ∘ 26.21\pm0.2^{\circ} , 26.82 ± 0.2 ∘ 26.82\pm0.2^{\circ} , 27.07 ± 0.2 ∘ 27.07\pm0.2^{\circ} , 27.93 ± 0.2 ∘ 27.93\pm0.2^{\circ} , 28.45 ± 0.2 ∘ 28.45\pm0.2^{\circ} , 29.24 ± 0.2 ∘ 29.24\pm0.2^{\circ} , 29.70 ± 0.2 ∘ 29.70\pm0.2^{\circ} , 30.12 ± 0.2 ∘ 30.12\pm0.2^{\circ} , 30.91 ± 0.2 ∘ 30.91\pm0.2^{\circ} , 31.32 ± 0.2 ∘ 31.32\pm0.2^{\circ} , 32.02 ± 0.2 ∘ 32.02\pm0.2^{\circ} , 32.81 ± 0.2 ∘ 32.81\pm0.2^{\circ} , 33.99 ± 0.2 ∘ 33.99\pm0.2^{\circ} , 35.51 ± 0.2 ∘ 35.51\pm0.2^{\circ} , 37.27 ± 0.2 ∘ 37.27\pm0.2^{\circ} ; b. the differential scanning calorimetry curve of the hydrochloride crystal form O has the onsets of the endothermic peaks at 12.36 ∘ C ± 2 ∘ C 12.36^{\circ}C \pm 2^{\circ}C and 174.87 ∘ C ± 2 ∘ C 174.87^{\circ}C \pm 2^{\circ}C ; c. the thermogravimetric analysis curve of the hydrochloride crystal form O has three weight loss steps at 27.70 ∘ C ± 2 ∘ C 27.70^{\circ}\text{C} \pm 2^{\circ}\text{C} , 115.00 ∘ C ± 2 ∘ C 115.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and 160.00 ∘ C ± 2 ∘ C 160.00^{\circ}\text{C} \pm 2^{\circ}\text{C} , and decomposition begins at 212.00 ∘ C ± 2 ∘ C 212.00^{\circ}\text{C} \pm 2^{\circ}\text{C} .

7. A method for preparing a crystal form of a pharmaceutically acceptable salt of the compound of formula (I) according to any one of claims 4-6, wherein, the method comprises the following steps: a. dissolving or dispersing the compound of formula (I) and an acid at a molar ratio of 1: (0.8–3) into 1-20 times of solvent A; b. performing suspension, recrystallization, or slurrying treatment; wherein the acid is not selected from hydrochloric acid (preferably, the acid is selected from the group consisting of: maleic acid, fumaric acid, glycolic acid, L-malic acid, succinic acid, sulfuric acid, L-tartaric acid, hippuric acid, glutaric acid, p-toluenesulfonic acid, or methanesulfonic acid); wherein solvent A is selected from the group consisting of: acetonitrile, dichloromethane, tetrahydrofuran, or a combination thereof; or the acid is hydrochloric acid or hydrogen chloride in dioxane; and the solvent A is selected from the group consisting of: ethyl acetate, 2-methyl-4-hydroxyfuran, butanone, ethanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, methyl isobutyl ketone, trifluoroethanol, water, methanol, tert-butyl methyl ether, toluene, isopropanol, dimethyl sulfoxide, isopropyl acetate, dichloromethane, or combinations thereof.

8. A method for preparing a crystal form of a pharmaceutically acceptable salt of the compound of formula (I) according to any one of claims 4-6, wherein, the method is a crystal form transformation by converting one crystal form of a pharmaceutically acceptable salt of the compound of formula (I) into another crystal form thereof; wherein the method of crystal form transformation comprises the following steps: a. dissolving or dispersing a crystal form of a pharmaceutically acceptable salt of the compound of formula (I) in 1-20 times of solvent A; b. performing suspension treatment; c. centrifuging the resulting suspension through a 0.4 to 0.5 µm filter membrane at a speed of 12,000 to 16,000 rpm; wherein the solvent A is selected from the group consisting of: ethanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, methyl isobutyl ketone, trifluoroethanol, methanol, 2- methyl-tetrahydrofuran, methyl tert-butyl ether, toluene, isopropanol, dimethyl sulfoxide, isopropyl acetate, dimethyl sulfoxide, methanol, dichloromethane, water, or a combination thereof.

9. A pharmaceutical composition comprising the compound of formula (I) according to any one of claims 1-2, the crystal form A according to claims 3, or the crystal form of the compound of formula (I) according to any one of claims 4-6; and one or more pharmaceutically acceptable carriers, excipients, adjuvants, ingredients, and / or diluents.

10. A use of the compound of formula (I) according to any one of claims 1-2, the crystal form A according to claims 3, the crystal forms of the compound of formula (I) according to any one of claims 4-6, and the pharmaceutical composition according to claim 9 in preparing a medicament for the prevention and / or treatment of diseases associated with increased activity or expression of FGFR2.