Novel sunscreen composition

Abstract

The invention is directed to a sunscreen composition with a water-soluble UVA and UVB sunscreens, wherein a weight ratio of the water-soluble UVA sunscreen to the water-soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1:3, more preferably, 2.5:1 to 1:2.5, even more preferably, 2:1 to 1:3; and a base, wherein from 80 wt% to 100 wt%, preferably from 85 wt% to 100 wt%, more preferably from 85 wt% to 95 wt% of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably from 80g / mol to 350g / mol, more preferably from 85 g / mol to 300 g / mol, and has a pKa value from 6 to 12, preferably, from 6 to 11.

Description

[0001] Novel Sunscreen Composition

[0002] Field of the invention

[0003] The present application is directed to a novel sunscreen composition and a method of using the same.

[0004] Background of the invention

[0005] Skin is exposed to various environmental stresses, such as UV rays, which cause free radicals to form in the skin. Sunscreens are widely used to protect skin from sundamage, sunburn, photo-aging, as well as to decrease the chances of skin cancer development caused by exposure to ultraviolet ("UV") radiation. The degree of UV protection afforded by a composition is directly related to the amount and type of UV filters contained therein, for example, UVA and UVB filters. It is desirable for sunscreen compositions to provide good protection against UV radiation, a measure of which is the Sun Protection Factor (SPF) value, a desirable balance between UVA and UVB protection.

[0006] While there are many sunscreen products available on the market, it has been recognized that aesthetic and performance problems still exist in many sunscreen products. Some of the drawbacks include what is known as “white-cast” which appears as a noticeable white film of the skin after the sunscreen composition is applied to the skin. This affect is more noticeable with melanin-rich skin which can cause consumers to avoid using sunscreen compositions leaving the skin vulnerable to the UV radiation and damage it causes.

[0007] Accordingly, described herein is a novel sunscreen composition that does not whiten the skin after application or after becoming wet with water or perspiration, has excellent skin-feel properties, and optionally is translucent or transparent and can provide some additional skin care benefits in addition to simply protecting skin from UV radiation. SUMMARY OF THE INVENTION

[0008] In a first aspect, a sunscreen composition comprises: a water-soluble UVA and UVB sunscreens, wherein a weight ratio of the water-soluble UVA sunscreen to the water- soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1 :3, more preferably, from 2.5:1 to 1 :2.5, even more preferably, from 2:1 to 1:3; and a base, wherein from 80 wt% to 100 wt%, preferably, from 85 wt% to 100 wt%, more preferably, from 85 wt% to 95 wt% of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably, from 80g / mol to 350g / mol, more preferably, from 85 g / mol to 300 g / mol, and has a pKa value from 6 to 12, preferably from 6 to 11.

[0009] In a second aspect, a method of treating the skin with a sunscreen composition as described herein.

[0010] In a third aspect, a use of a sunscreen as described herein for protecting the skin from damage caused by ultraviolet radiation.

[0011] In another aspect, use of water-soluble sunscreens and an organic base to create a translucent and / or transparent composition.

[0012] All other aspects of the present invention will more readily become apparent from the description and examples which follow.

[0013] DETAILED DESCRIPTION OF THE INVENTION

[0014] Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and / or use may optionally be understood as modified by the word “about”.

[0015] All amounts are by weight of any of the compositions or components thereof, unless otherwise specified. It should be noted that in specifying any ranges of values, any particular upper value can be associated with any particular lower value. For the avoidance of doubt, the term "comprising" is meant not to be limiting to any stated elements but rather to encompass non-specified elements of major or minor functional importance. Therefore, the listed steps, elements or options need not be exhaustive. Whenever the words "including" or "having" are used, these terms are meant to be equivalent to "comprising" as defined above.

[0016] The disclosure, as found herein, is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy.

[0017] “Skin”, as used herein, includes skin on the face, neck, chest, back, arms (including underarms), axilla, buttocks, hands, legs and scalp.

[0018] “Skin care benefit”, as used herein, refers to an improvement in a facial or body characteristic after topical application, for example, even skin tone such as skin brightening and / or glow, skin texture such as reduction in wrinkles, fine lines and / or age spots, dry skin, anti-acne or the like. A “skin care benefit agent” can be used to address these skin care benefits.

[0019] “Skin-feel properties”, as used herein, refers to the sensation of applying the composition to the skin, such as glides easily across the skin (e.g., highly spreadable), does not feel greasy or tacky but instead a silky feel, is quickly absorbed into the skin, and / or having a cooling sensation after being applied to the skin.

[0020] As used herein, “substantially free of” refers having less than 3 wt%, or less than 1 wt%, or less than 0.5 wt%, or less than 0.1 wt%, or less than 0.01 wt% of the compound, by weight of the composition, preferably free of such compound (e.g., 0.0 wt%).

[0021] In one aspect, a sunscreen composition comprises: a water-soluble UVA and UVB sunscreens, wherein a weight ratio of the water-soluble UVA sunscreen to the water- soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1 :3, more preferably, from 2.5:1 to 1 :2.5, even more preferably, from 2:1 to 1:3; and a base, wherein from 80 wt% to 100 wt%, preferably from 85 wt% to 100 wt%, more preferably from 85 wt% to 95 wt% of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably from 80g / mol to 350g / mol, more preferably from 85 g / mol to 300 g / mol, and has a pKa value from 6 to 12, preferably from 6 to 11.

[0022] Sunscreen

[0023] The composition described herein comprises a water-soluble UVA sunscreen and a water-soluble UVB sunscreen. In one aspect, the water-soluble UVA sunscreen is present in the composition in a range from 0.5 wt% to 15 wt%, preferably, from 1 wt% to 10 wt%, more preferably, from 1.5 wt% to 6 wt%, even more preferably, from 1.5 wt% to 4 wt%, based on the total weight of the sunscreen composition. In one aspect, the water-soluble UVB sunscreen is present in the composition in a range from 0.5 wt% to 15 wt%, preferably, from 1 wt% to 13 wt%, more preferably, from 2 wt% to 8 wt%, even more preferably, from 2.5 wt% to 7 wt%, based on the total weight of the sunscreen composition. In one aspect, the weight ratio of the water-soluble UVA sunscreen to the water-soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1:3, more preferably, from 2.5:1 to 1:2.5, even more preferably, from 2:1 to 1:3. Preferably, the water-soluble UVA sunscreen is bisdisulizole disodium and the water- soluble UVB sunscreen is ensulizole.

[0024] The composition described herein may optionally include one or more oil-soluble sunscreens, such as an oil-soluble UVA and / or oil-soluble UVB sunscreen. Nonlimiting examples of suitable oil-soluble sunscreens include octyl salicylate, 3,3,5- trimethylcyclohexyl 2-hydroxybenzoate (“homosalate”), ethylhexyl salicylate (“octisalate”), 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate (or octocrylene), or 2- ethylhexyl-4-methoxycinnamate (also known as octyl methoxycinnamate or “OMC”), 4- t-butyl-4’-methoxydibenzoylmethane (“avobenzone”), 2-methyldibenzoylmethane, 4- methyl-dibenzoyl-ethane, 4-isopropyldibenzoyl-methane, 4-tert- butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5- dimethyldibenzoylmethane, 4,4’-diisopropyldibenzoylmethane, 2-methyl-5-isopropyl-4’- methoxy-dibenzoylmethane, 2-methyl-5-tert-butyl-4’-methoxy-dibenzoylmethane, 2,4- dimethyl-4’-methoxydibenzoylmethane, 2,6-dimehyl-4-tert-butyl-4’methoxy- dibenzoylmethane, diethylaminohydroxybenzoyl hexyl benzoate, or methyl anthranilate. Another suitable oil-soluble sunscreen includes Bemotrizinol (BEMT). Additional oil-soluble sunscreens include those commercially available from BASF corporation: Uvinul T-150 (Ethylhexyl triazone; a UV-B sunscreen oil), Uvinul A Plus (Diethylamino hydroxy benzoyl hexyl benzoate; a IIV-A sunscreen oil), Tinosorb S (bisethylhexyloxyphenol methoxyphenyl triazine; a IIV-A and IIV-B sunscreen oil), Tinosorb M(methylene bisbenzotriazolyl tetramethylbutylphenol; a IIV-A and IIV-B sunscreen oil), Mexoryl XL, and / or Mexoryl 400.

[0025] In one aspect, from 0 wt% to 50 wt%, or from 5 wt% to 50 wt%, or from 10 wt% to 45 wt%, or from 15 wt% to 40 wt%, of the total amount of sunscreen in the sunscreen composition is an oil-soluble sunscreen. In one aspect, the sunscreen composition is substantially free of oil-soluble sunscreens.

[0026] The total amount of sunscreen in the composition described herein (e.g., water-soluble UVA sunscreen, water-soluble UVB sunscreen, and optional oil-soluble sunscreen(s)) is from 4 wt% to 30 wt%, preferably, from 5 wt% to 25 wt%, and more preferably, from 6 wt% to 25 wt%, or from 6 wt% to 20 wt%, or from 8 wt% to 22 wt%, based on the total weight of the sunscreen composition.

[0027] Base

[0028] The composition described herein also comprises a base, wherein from 80 to 100 wt%, preferably, from 85% to 100 wt%, more preferably, from 85 to 95 wt%, of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably, from 80g / mol to 350g / mol, more preferably, from 85 g / mol to 300 g / mol. In one aspect, the organic base has a pKa from 6 to 12, preferably, from 6 to 11 , where pKa is a measurement of acidity taken at 20-30°C. In one aspect, the organic base is selected from monoamines, diamines, polyamines, and any combinations thereof, preferably, such that from 80 wt% to 100 wt%, from 90 wt% to 100 wt%, or from 95 wt% to 100 wt% of the organic base is a monoamine and / or a diamine. As used herein, a monoamine is a compound having a single amino group, a diamine is a compound having two amino groups, and a polyamide is a compound having more than two amino groups. Non-limiting examples of suitable organic bases include triethylamine, tetrahydroxypropyl ethylenediamine, aminomethyl propanol, triethanolamine, and / or N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine. In one aspect, the organic base is triethanolamine. In one aspect, the organic base is tetrahydroxypropyl ethylenediamine and triethanolamine, preferably, in a weight ratio from 3:1 to 1 :3, more preferably, from 2:1 to 1 :2, more preferably, from 1 :1 to 1 :2. The composition described herein may optionally include one or more inorganic base, preferably having a molecular weight of from 20 g / mol to 75 g / mol, more preferably, from 35g / mol to 60 g / mol. In one aspect, the composition includes from 0 wt% to 20 wt%, or from 0 wt% to 15 wt%, or from 0 wt% to 10 wt%, or from 0.1 wt% to 10 wt%, or from 2 wt% to 15 wt%, or from 2 wt% to 10 wt%, or from 2 wt% to 5 wt%, or from 5 wt% to 15 wt%, based on the total amount of the base in the sunscreen composition. In one aspect, the composition is substantially free of an inorganic base. Non-limiting examples of suitable inorganic bases include sodium hydroxide, potassium hydroxide, ammonium hydroxide and / or hydroxides or oxides of alkali metals or alkaline-earth metals. In one aspect, an alkali metal may be, for example, a sodium, lithium, and / or potassium, and an alkaline earth metal may be, for example, a calcium or magnesium, and an ammonium salt may be NH4+ and / or NR4+, with R being an alkyl group, optionally substituted with one of more hydroxy and / or alkoxy groups. Alkyl, as used herein, means carbon chains which may be linear or branched, or combinations thereof, containing the indicated number of carbon atoms. In particular embodiments, linear alkyl groups have 1-20 carbon atoms and branched alkyl groups have 3-20 carbon atoms. Examples of alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, sec- and tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl and the like.

[0029] The compositions described herein can be formulated to achieve a variety of different Sun Protection Factors (SPFs). For example, the composition described herein can have an SPF of at least 5, or at least 10, or at least 15. In some aspect, the composition described herein can have an SPF of at least 5, or 10, or 15, or 20, or 25, or 30, or 35, or 40, or 45, or 50, of 55, or 60, or 65, or 70. Preferably, composition described herein can have an SPF of from 10 to 60, more preferably, from 15 to 55, and even more preferably, from 15 to 50.

[0030] It was unexpectedly discovered that the composition described herein achieve a consumer desired SPF while not resulting in white-cast (e.g., white residue on skin) after being applied to skin and has excellent skin-feel properties.

[0031] Other optional ingredients

[0032] Silicone materials of liquid, solid or semi-solid consistency at room temperature may optionally be included in the composition described herein. Liquid silicones include silicone oils which may be divided into the volatile and nonvolatile variety. The term "volatile" as used herein refers to those materials which have a measurable vapor pressure at ambient temperature. Volatile silicone oils are preferably chosen from cyclic (cyclomethicone) or linear polydimethylsiloxanes containing from 3 to 9, preferably, from 4 to 5, silicon atoms, preferably, cyclotetrasiloxane (D4), cyclopentasiloxane (D5), cyclohexasiloxane (D6), hexamethyldisiloxane, and / or mixtures thereof. Nonvolatile silicones include nonvolatile silicone oils such as polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers, including dimethicones and caprylyl methicone, emulsifying and non-emulsifying silicone elastomers such as dimethicone / vinyl dimethicone crosspolymer, and silicone waxes such as dimethicone copolyol laurate. The total amount of silicone materials is from 0.01 wt% to 3 wt%, preferably, from 0.1 wt% to 2.5 wt%, more preferably, from 0.5 wt% to 2.25 wt%, based on the total weight of the sunscreen composition. In one aspect, the composition described herein is substantially free of silicones. Even without silicone materials, the composition described herein was able to maintain excellent skin-feel properties.

[0033] In one aspect, the composition is substantially free of silicone acrylates comprising at least one copolymer comprising carboxylate groups and polydimethylsiloxane groups.

[0034] In one aspect, the total amount of oil-soluble lipophilic material(s) with a Hansen Total Solubility Parameter (St) in a range from 10 to 22 (e.g., optional oil-soluble sunscreens and silicone materials) is from 0.001 wt% to 15 wt%, or from 0.001 wt% to 12 wt%, or from 0.001 wt% to 10 wt%, or from 0.01 wt% to 8 wt%, or from 0.01 wt% to 7 wt%, or from 0.001 wt% to 6 wt%, based on the total weight of the sunscreen composition. Hansen total solubility parameters (St) are determined based on three Hansen parameters, namely bd (defines energy from dispersion forces between molecules), bp (defines energy from dipolar intermolecular forces between molecules), and bh (defines energy from hydrogen bonds between molecules), bt values are obtained according to the CRC Handbook of Solubility Parameters and other Cohesion Parameters, Second Edition by Allan F.M. Barton. Illustrative examples include ethylhexyl methoxycinnamate (Parsol MCX) (bt =18.4), cyclopentasiloxane (bt =11.8), and isopropyl palmitate (bt =17.1). Without being bound to a particular theory, the present composition is able to achieve a cooling sensation by having a low load of oils, such as oil-soluble lipophilic materials (e.g., optional oil soluble sunscreens and silicones), in addition to having a consumer desired SPF while not resulting in whitecast.

[0035] In one aspect, the sunscreen composition has less than or equal to 10%, preferably, 0.01 wt% to 10 wt%, or from 0.01 wt% to 8 wt%, or from 0.01 wt% to 7 wt%, of oilsoluble lipophilic material(s) with a Hansen Total Solubility Parameter (St) in a range from 10 to 22, based on the total weight of the sunscreen composition, and the sunscreen composition is transparent or translucent. In one aspect, the sunscreen composition is substantially free of oil-soluble lipophilic materials and is transparent or translucent. "Translucent" or “transparent” is quantified with UV-vis spectroscopy (e.g., PerkinElmer LAMBDA 465 UV / Vis Spectrophotometer). For example, to test for transparency and / or translucency, a 0.5 mm pathlength UV quartz demountable cuvette cell (e.g., Type 19, supplied by FireflySci Cuvette Shop) is used in A20 cuvette mount holder, ensuring there are no air bubbles under cover slide, and a translucency value is reported as the average transmittance across the visible spectrum (400 to 700nm). As used herein, “transparent” refers to a translucency index >90, and “translucent” refers to a translucency index between 30-90. The transparent or translucent compositions may be colored or colorless.

[0036] Gelling agents may optionally be included in the sunscreen compositions. Examples of suitable hydrophilic gelling agents include carboxyvinyl polymers such as the Carbopol products (carbomers, such as Carbopol llltrez 21) and the Pemulen products (acrylate / C10-C30-alkylacrylate copolymer); polyacrylamides and polyacrylates, for instance, the crosslinked copolymers sold under the names Sepigel 305 (CTFA name: polyacrylamide / C13-14 isoparaffin / Laureth 7) or Simulgel 600 (CTFA name: acrylamide / sodium acryloyldimethyltaurate copolymer / isohexadecane / polysorbate 80) or Sepimax Zen (polyacrylate crosspolymer-6) by the company SEPPIC; 2-acrylamido- 2-methylpropanesulfonic acid polymers and copolymers, which are optionally crosslinked and / or neutralized, for instance the poly(2-acrylamido-2- methylpropanesulfonic acid) (CTFA name: ammonium polyacryldimethyltauramide) Lipophilic gelling agents may also be included, for example, modified clays such as hectorite and its derivatives. The gelling agent may also be ammonium acryloyldimethyltaurate / steareth-25 methacrylate crosspolymer, commercially available from Clariant under the tradename Aristoflex HMS. In one aspect, the composition described herein has at least one gum, preferably, xanthan gum. Other suitable gelling agents include polysaccharides, which comprise of starches, natural / synthetic 20 gums, and cellulosics. Desirable starches include tapioca starch, corn starch, potato starch, aluminum starch octenylsuccinate, and sodium hydroxypropyl starch phosphate. Desirable gums include xanthan, sclerotium, pectin, karaya, arabic, agar, guar, carrageenan, alginate, and combinations thereof. Desirable cellulosics include hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethylcellulose, and sodium carboxy methylcellulose. The total amount of the gelling agent is from 0.5 wt% to 3 wt%, preferably, from 0.75 wt% to 2.5 wt%, more preferably, from 1 wt% to 2.25 wt%, based on the total weight of the sunscreen composition.

[0037] Conventional humectants, generally of the polyhydric alcohol-type materials, are suitable for optional use. Typical polyhydric alcohols include glycerol (i.e. , glycerine or glycerin), propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, polyethylene glycol ethers of glycerin (e.g., glycereth), sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof, preferably, glycerin, propylene glycol or a mixture thereof. Other suitable humectants include water soluble esters and ethers such as Glycereth-7 Triacetate, Glycereth-5 Lactate, PEG / PPG-8 / 3 Laurate, Polyglyceryl-3 Laurate, PPG-20 Methyl Glucose Ether, Methyl Gluceth-20, and Methyl Gluceth-10.

[0038] The total amount of the humectant is from 0.01 wt% to 50 wt%, or from 0.01 wt% to 40 wt%, or from 0.01 wt% to 30 wt%, or from 0.01 wt% to 25 wt%, or from 0.01 wt% to 20 wt%, or from 0.1 wt% to about 15 wt%, or from 0.5 wt% to 10 wt%, based on the total weight of the sunscreen composition. In one aspect, the composition is substantially free of volatile alcohols having a molecular weight of greater than or equal to 60 g / mol, such as ethanol and isopropyl alcohol. Conventional preservatives can desirably be incorporated into the sunscreen composition to protect against the growth of potentially harmful microorganisms. Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy the preservative challenge test and to provide product stability. While traditional preservatives may be used, such as hydantoin derivatives, isothiazolinones, methyl paraben and / or propyl paraben, as described herein the sunscreen composition of the present invention is preferably substantially free of the same. Other preservatives suitable for use may include iodopropynyl butyl carbamate, phenoxyethanol, hydroxyacetophenone, ethylhexylglycerine, hexylene glycol, imidazolidinyl urea, sodium dehydroacetate, benzyl alcohol, sodium benzoate or mixtures thereof. Even other preservatives suitable for use include sodium dehydroacetate, chlorophenesin and decylene glycol. The preservatives should be selected having regard for the use of the composition and possible incompatibilities between the preservatives and other ingredients in the composition. Preservatives are preferably employed in amounts from 0.01 wt% to 2.0 wt%, based on the total weight of the sunscreen composition. Also preferred is a preservative system with hydroxyacetophenone alone or in a mixture with other preservatives. Use of common emollients classified as vicinal diols, like 1 ,2-octane diol (or other vicinal alkane diols), are also suitable for use with the preservatives described herein and typically at amounts ranging from 0.15 wt% to 1.5 wt%, and preferably, from 0.2 wt% to 1.25 wt%, and most preferably, from 0.25 wt% to 1 wt%, or 0.25 wt% to 0.8 wt%, based on the total weight of the sunscreen composition. In another embodiment of the invention, another preservative suitable for optional use in the present invention comprises capryloyl glycine, undecylenoyl glycine or a mixture thereof. In one aspect, the composition is substantially free of parabens.

[0039] Solubilizing agents may optionally be included in the sunscreen composition such as polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, PEG-40 hydrogenated castor oil, and mixtures thereof. Each of these substances may range from 0.01 wt% and 3 wt%, or from 0.02 wt% to 1.2 wt%, or from 0.1 wt% to 1 wt%, based on the total weight of the sunscreen composition.

[0040] Fragrances, fixatives, chelators (like EDTA, sodium phytate, tetra sodium glutamate diacetate and / or sodium gluconate) may optionally be included in the sunscreen composition. The total amount of these substances may range from 0.05 wt% to 5 wt%, preferably, from 0.01 and 3%, more preferably, from 0.1 to 2.5 wt%, based on the total weight of the sunscreen composition.

[0041] In one aspect, the pH of the sunscreen composition is from 6 to 8.5, or from 6.5 to 8.25, or from 7 to 8. pH may be measured by use of a pH meter, such as the Orion Star A111 Benchtop pH meter made commercially available from Thermo Scientific. Skin Care Benefit Agents

[0042] In one aspect, the sunscreen composition comprises: a water-soluble UVA and UVB sunscreens, wherein a weight ratio of the water-soluble UVA sunscreen to the water- soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1 :3, more preferably, from 2.5:1 to 1 :2.5, even more preferably, from 2:1 to 1:3; and a base, wherein from 80 wt% to 100 wt%, preferably, from 85 wt% to 100 wt%, more preferably, from 85 wt% to 95 wt% of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably, from 80g / mol to 350g / mol, more preferably, from 85 g / mol to 300 g / mol, and has a pKa value from 6 to 12, preferably, from 6 to 11 , and optionally at least one skin care benefit agent. In addition to being unexpectedly discovered that the composition described herein achieve a satisfactory SPF while not resulting in any white-cast after being applied to the skin with excellent skin-feel properties, a skin care benefit agent could also be added to such formulation while maintaining all of the benefits of the present invention and providing even more benefits to the consumer.

[0043] Skin care benefit agents include vitamin B1 and its precursors or derivatives (such as thiamine), vitamin B3 and its precursors or derivatives (such as niacinamide); vitamin B5 and its precursors or derivatives (such as panthenol and its precursors or derivatives); vitamin C and its precursors or derivatives (such as tetrahexyldecyl ascorbate, ascorbyl palmitate); and alpha lipoic acid. When used, from 0.0001 to 10% or from 0.001 to 8%, and most preferably, from 0.01 to 5% or from 0.01 to 3% or from 0.01 to 2% or from 0.01 to 1% by weight of each of such ingredients are used, based on the total weight of the sunscreen composition.

[0044] Skin benefit agents also include glutathione precursors such as a glutamate source (e.g., glutamate) and cystine and, optionally, glycine, as well as salts and esters thereof. Glutamate source can be present in the form of its functional equivalents including glutamine, glutamic acid and / or pyroglutamic acid and / or their salts. In another aspect, a carboxymethyl cysteine compound can be used. The carboxymethyl cysteine compound refers to compound selected from carboxymethyl cysteine, salt of carboxymethyl cysteine, ester of carboxymethyl cysteine, amide of carboxymethyl cysteine or a mixture thereof. Preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and / or salt of carboxymethyl cysteine. More preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, and / or salt of carboxymethyl cysteine. Even more preferably, carboxymethyl cysteine compound comprises salt of carboxymethyl cysteine. Still even more preferably the carboxymethyl cysteine compound comprises lysine carboxymethyl cysteinate and most preferably, the carboxymethyl cysteine compound is lysine carboxymethyl cysteinate.

[0045] Skin care benefit agents also include S-adenosyl-L-methionine, a 1 -alkyl nicotinamide having structure I, and a methionine having structure II: wherein Rc is a C1-C4 alkyl, preferably, methyl (N-methyl nicotinamide) and X- is a negative counter ion, preferably, CI-, Rd is methyl, ethyl, propyl, hydroxymethyl, 2- hydroxyethyl, preferably, methyl and Re is H, methyl, ethyl, isopropyl, preferably, H (N- acetyl methionine). Such components are described in WO / 2021 / 008824A1 , the disclosure of which is incorporated herein by reference. When used, from 0.0001 to 10% or from 0.001 to 8%, and most preferably, from 0.01 to 5% or from 0.01 to 3% or from 0.01 to 2% or from 0.01 to 1% by weight of each of such ingredients are used, based on the total weight of the sunscreen composition. In even another embodiment, the sunscreen composition may comprise acetyl cysteine at from 0.001 to 1.8% by weight.

[0046] Additional optional skin care benefit agent include: resorcinols, oil-soluble vitamins, fatty acids, PPARs, anti-irritants, extracts, and other oils. When used, from 0.0001 to 3% or from 0.001 to 2%, and most preferably, from 0.01 to 1.5% or from 0.01 to 1% or from 0.01 to 0.5% by weight of each of such ingredients are used, based on the total weight of the sunscreen composition.

[0047] A resorcinol, which is a monohydroxy phenol compound (i.e., 1 ,3-dihydroxybenzene or 1 ,3-benzenediol) characterized by alcohol groups (—OH) at positions 1 and 3. The chemical structure of resorcinols may be modified, resulting in substituted resorcinols characterized by at least one substituent in the 2, 4, 5 or 6 position. Substituted, as used herein, refers to a compound in which one or more hydrogen atoms are replaced by another atom or group, e.g., substituent. In one aspect, the substituted resorcinol comprises at least one substituent comprising 5 to 11 carbon atoms, or 5 to 9 carbon atoms. In one aspect, the substituted resorcinol has at least one substituent comprised of an alkyl group or unsaturated alkyl group.

[0048] In one aspect, the substituted resorcinol is only substituted at position 4 with an alkyl group, e.g., the substituted resorcinol is a 4-substituted alkyl resorcinol, including but not limited to 4-methyl resorcinol, 4-ethyl resorcinol, 4-hexyl resorcinol, 4-cyclohexyl resorcinol, 4-propyl resorcinol, 4-isopropyl resorcinol, 4-butyl resorcinol, 4-pentyl resorcinol, 4-phenylethyl resorcinol, 4-cyclopentyl resorcinol, 4-cyclohexyl resorcinol, 4-heptyl resorcinol, 4-cycloheptyl resorcinol, 4-octyl resorcinol, 4-cyclooctyl resorcinol, 4-nonyl resorcinol, 4-decyl resorcinol, 4-undecyl resorcinol, 4-dodecyl resorcinol and / or combinations or mixtures thereof. Preferably, the substituted resorcinol is 4- ethylresorcinol, 4-hexylresorcinol, and 4-isopropylresorcinol. In one aspect, the substituted resorcinol is substituted at position 4 with a substituted or unsubstituted 5- or 6-membered ring carbon-based heterocyclic ring containing one or more heteroatoms selected from N, S or O, preferably a substituted 5-membered ring carbon-based heterocyclic ring containing two heteroatoms selected from N or S, e.g., isobutylamido thiazolyl resorcinol or thiamidol.

[0049] Oil-soluble vitamins include vitamin A and its precursors or derivatives including retinoids such as retinol, beta-carotene, retinal, retinoic acid and C2-20 esters of retinol (such as retinyl palmitate, retinyl propionate, retinyl formate, retinyl acetate, retinyl butyrate, retinyl valerate, retinyl isovalerate, retinyl hexanoate, retinyl heptanoate, retinyl octanoate, retinyl nonanoate, retinyl decanoate, retinyl undecandate, retinyl taurate, retinyl tridecanoate, retinyl myristate, retinyl pentadecanoate, retinyl heptadeconoate, retinyl stearate, retinyl isostearate, retinyl nonadecanoate, retinyl arachidonate, retinyl behenate, retinyl linoleate, and retinyl oleate); vitamin D and its precursors or derivatives, vitamin E and its precursors or derivatives (such as d-alpha- tocopherol, tocopheryl acetate); vitamin K and its precursors or derivatives; selenium and its derivatives (such as L-selenomethionine).

[0050] A peroxisome proliferator-activated receptor (PPAR) activator are also suitable additional optional skin care benefit agents such as 10- hydroxy stearic acid (10-HSA), 12-hydroxystearic acid (12-HSA), cis parinaric acid, trans-7-octadecenoic acid, cis 5,8,11 ,14,17 eicosapentanoic acid, cis-4,7, 10, 13, 16, 19 docosahexenoic acid, conjugated linoleic acid (c9,t11), columbinic acid, linolenelaidic acid, ricinolaidic acid, stearidonic acid, 2- hydroxy stearic acid, alpha-linolenic acid, arachidonic acid, cis- 11 ,14-eicosadienoic acid, conjugated linoleic (t10,c12), conjugated linoleic acid (t9,t11), conjugated linoleic acid (50:50 mix of c9, t11 and t10 c12), coriander acids, linolelaidic acid, monopetroselinic acid, petroselinic acid, ricinoleic acid, stearolic acid, thuja extract or trans vaccenic acid. Even other PPAR activators include cis-11 ,14,17 eicosatrienoic acid, cis-5 eicosenoic acid, cis-8, 11,14 eicosatrienoic acid, hexadecatrienoic acid, palmitoleic acid, petroselaidic acid, farnesol, cis 13, 16 docosadienoic acid, cis vaccenic acid, cis-11 eicosenoic acid, cis-13, 16, 19 docosatrienoic acid, cis-13-octadecenoic acid, cis-15-octadecanoic acid, cis- 7,10,13,16 docosatetraenoic acid, elaidic acid, gamma-linolenic acid, geranic acid, geranyl geranoic acid, linoleic acid, petroselinyl alcohol, phytanic acid, pinolenic acid, trans- 13-octadecenoic acid or tridecyl salicylic acid (TDS). Still other PPAR activators include biochanin A (red clover phytoestrogen), chromolaena odorata extract, pomegranate saponifiable hydrolysable extract, buglossoides (stearidonic plant extract) or zanthalene (extract from Sichuan peppercorn), whereby it is within the scope of the invention to use a mixture of any of the herein noted PPAR activators. In an embodiment of the invention, the PPAR activator is petroselinic acid, conjugated linoleic acid, 12-hydroxystearic acid, ricinoleic acid or a mixture thereof.

[0051] Other additional optional skin care benefit agents include fatty acids containing from 8 to 30 carbon atoms (such as stearic acid, lauric acid, palmitic acid and oleic acid).

[0052] Anti-irritants suitable as additional optional skin care benefits agents in the invention include allantoin, aloe vera, a-bisabolol, caffeine, chamomile extract, Cola nitada extract, cucumber extract, dipotassium glycyrrhizinate, glycyrrhizic acid, green tea extract, lecithin or hydrogenated lecithin, licorice extract, tea tree oil, strontium acetate, strontium chloride, strontium nitrate, and aromatic aldehydes with anti-irritant properties (such as 4-methoxy benzaldehyde, 4-ethoxy benzaldehyde, 4-butoxy benzaldehyde and 4-pentoxy benzaldehyde). In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. Other additional optional skin care benefit agents include ceramides (e.g., ceramide 1 , ceramide 3 and / or ceramide 6), alpha-hydroxycarboxylic acids (known as AHAs), and coenzyme Q10.

[0053] Other additional optional skin care benefit agents include at least one of benzethonium chloride, benzalkonium chloride, cetrimonium chloride, zinc pyrithione, chloroxylenol, salicylic acid, citric acid, lactic acid, eugenol, terpineol, thymol, selenium sulfide, piroctone olamine, hinokitiol, linalool, cinnamon oil, lemon grass oil, eucalyptus, vanilla extract, mint extract, orange extract, linseed oil, flaxseed oil or a mixture thereof. If any of such are selected for use, the total amount of those selected for use will (in combined total) be from 0.001 to 4.5%, or from 0.01 to 3.5% or from 0.01 to 2.5% or from 0.02 to 1 % by weight of the sunscreen composition.

[0054] The composition as described herein are water continuous emulsions and can be in the form of a liquid, lotion, cream, foam, scrub, gel, soap bar or toner, or applied with an implement or via a face mask, pad or patch. Non-limiting examples of such compositions include leave-on skin lotions, creams, antiperspirants, deodorants, lipstickssunless tanners, and sunscreen lotions s. Also, the composition may be a spray-on.

[0055] In one aspect, the sunscreen composition is the combination of water-soluble sunscreens, base, and water (e.g., sunscreen premix) and later added to a chassis or emulsion. In one aspect, the sunscreen premix comprises up to 25% of water-soluble sunscreens, preferably, about 10-15% of water-soluble UVB sunscreen, preferably ensulizole, and 5-15% of a water-soluble UVA sunscreen, preferably, bisdisulizole disodium, and up to 25%, preferably 5-25%, more preferably, 10 to 20% of a base, preferably one or more organic bases.

[0056] The sunscreen composition described herein may be made by conventional method known to those skilled in the art.

[0057] In one aspect, a method of treating the skin with a sunscreen composition as described herein.

[0058] In one aspect, the composition is initially clear in appearance and remains clear in appearance upon application onto skin (e.g., no white cast). In one aspect, the composition described herein is used for protecting the skin from damage caused by ultraviolet radiation.

[0059] Examples

[0060] The following Examples are provided to further illustrate an understanding of the invention. The Examples are not intended to limit the scope of the claims.

[0061] Example 1

[0062] Sunscreen compositions (Examples A-C and l-l V) were made with the ingredients identified in Table 1.

[0063] Table 1 :

[0064] Subsequent to making the samples, each composition was tested on skin to determine if a white residue (e.g., white cast) was present after application to skin (e.g., rubbing the composition on the skin). Surprisingly and unexpectedly, the composition of the present invention (e.g., Examples l-l V) did not leave any white residue on the skin, whereas each of the comparative examples, there was a white residue on the skin after applicable of the sunscreen composition. The compositions of the present invention also maintained the excellent skin-feel properties, were translucent and / or transparent, and satisfactory SPF properties.

[0065] Example 2

[0066] Sunscreen composition (Example V) was made with the ingredients identified in Table 2.

[0067] Table 2:

[0068] Subsequent to making this sample, the composition was tested on skin to determine if a white residue (e.g., white cast) was present after application to skin (e.g., rubbing the composition on the skin). Surprisingly and unexpectedly, the composition of the present invention (e.g., Examples V) did not leave any white residue on the skin, was transparent, and had excellent skin-feel properties without silicone and satisfactory SPF properties with only water soluble sunscreens. Example 3

[0069] Sunscreen compositions (Examples 1-3) was made with the ingredients identified in

[0070] Table 3.

[0071] Table 3:

Claims

Claims1. A composition comprising: water-soluble UVA and UVB sunscreens selected from bisdisulizole disodium and ensulizole, wherein a weight ratio of the water-soluble UVA sunscreen to the water-soluble UVB sunscreen is from 4:1 to 1:4, preferably, from 3:1 to 1:3, more preferably, from 2.5:1 to 1 :2.5, even more preferably, from 2:1 to 1:3; and a base, wherein from 80 wt% to 100 wt%, preferably, from 85 wt% to 100 wt%, more preferably, from 85 wt% to 95 wt% of a total amount of the base is an organic base having a molecular weight of at least 80g / mol, preferably, from 80g / mol to 350g / mol, more preferably, from 85 g / mol to 300 g / mol, and has a pKa value from 6 to 12, preferably, from 6 to 11, wherein the base is tetrahydroxypropyl ethylenediamine and triethanolamine, preferably, in a weight ratio from 3:1 to 1 :3, and wherein the composition is substantially free of silicones.

2. The composition of claim 1 further comprising an oil-soluble sunscreen, preferably, an oil-soluble UVB sunscreen and / or an oil-soluble UVA sunscreen.

3. The composition of any of the preceding claims, wherein a total amount of sunscreen is from 4 wt% to 30 wt%, preferably, from 5 wt% to 25 wt%, more preferably, from 6 wt% to 25 wt%, or from 6 wt% to 20 wt%, or from 8 wt% to 22 wt%.

4. The composition of any of the preceding claims, wherein a pH of the composition is from 6 to 8.5, preferably, from 6.5 to 8.25, more preferably, from 7 to 8.

5. The composition of any of the preceding claims, wherein the total amount of base optionally comprises an inorganic base having a molecular weight of from 20 g / mol to 75 g / mol, preferably, from 35g / mol to 60 g / mol,selected from sodium hydroxide, potassium hydroxide, ammonium hydroxide, and / or hydroxides or oxides of alkali metals or alkaline-earth metals.

6. The composition of any of the preceding claims, wherein a total amount of oil-soluble lipophilic material having a Hansen Total Solubility Parameter in a range from 10 to 22 is from 0.001 wt% to 10 wt%, preferably, from 0.01 wt% to 8 wt%, and most preferably, from 0.01 wt% to 7 wt%, based on the total weight of the sunscreen composition.

7. The composition of any of the preceding claims further comprising at least one skin care benefit agent.

8. The composition of any of the preceding claims, wherein the composition is translucent and / or transparent.

9. A method of treating the skin comprising applying the composition of any of the preceding claims to skin.

10. Use of the composition of any of the preceding claims for protecting the skin from damage caused by ultraviolet radiation.