Light radiation device, light radiation system, and method for operating light radiation device

Abstract

A light radiation device capable of effectively expressing the OPN5 gene or activating OPN5 by radiating light to an eye is provided. The device includes a light source that radiates light having a wavelength in a wavelength region overlapping an absorption spectrum of OPN5, and a radiation condition of the light is set to express the OPN5 gene or activate OPN5. A spectrum of the radiated light may be set so that a maximum value of a received effective spectral irradiance, calculated as a per-wavelength product of spectral irradiance in a wavelength region of 280 to 500 nm and a relative absorbance of OPN5 absorption spectral data, is at least 0.2% of a maximum value of a reference effective spectral irradiance calculated from an AM1.5G sunlight spectrum and the OPN5 absorption spectral data.

Description

Light irradiation device, light irradiation system, and method for operating a light irradiation device

[0001] The present invention relates to a light irradiation device, a light irradiation system, and a method for operating a light irradiation device. More specifically, the present invention relates to a light irradiation device, a light irradiation system, and a method for operating a light irradiation device that can irradiate light onto an eye and effectively express OPN5 gene or activate OPN5 by light.

[0002] The effects of light on the human body have been studied from various perspectives in recent years, and reports based on new findings have been published. For example, it has been reported that exposure to sunlight improves circadian rhythms (Non-Patent Document 1), that light emitted from LED lighting and liquid crystal displays using LEDs as backlights has a significant effect on the body and mind (Non-Patent Document 2), and that violet light prevents and suppresses the onset of myopia (Patent Document 1). In particular, the present inventor has recently reported on the effects of violet light on myopia. For example, Patent Document 1 and Non-Patent Document 3 propose that light of a specific wavelength has the effect of preventing or suppressing the progression of myopia, and this has generated great expectations in recent years as the number of people suffering from myopia continues to increase worldwide.

[0003] Opsin 5 (OPN5) is known as a photoreceptor protein, and research into its visual and non-visual functions in humans and animals is ongoing (Non-Patent Document 4).

[0004] Megumi Hatori, Kazuo Tsubota, Anti-Aging Medicine - Journal of the Japanese Society of Anti-Aging Medicine, Vol. 11, No. 3, 065(385)-072(392), (2015). Kazuo Tsubota, "Blue Light: A Threat to the Biological Clock," Shueisha, November 20, 2013. Hidemasa Torii et al., EBioMedicine, "DOI: http: / / dx.doi.org / 10.1016 / j.ebiom.2016.12.007". Takahiro Yamashita, "A Novel Ultraviolet Photoreceptor Protein in Vertebrates - Do Humans Also Sensitize UV ​​Light?", Biophysics, 51(4), 186-187 (2011).

[0005] WO2015 / 186723A1

[0006] OPN5 exhibits an absorption spectrum with a peak at 380 nm, as shown in Figure 1. If OPN5 can be effectively activated, it is expected that its relationship with visual and non-visual functions, as well as its relationship with the inhibition of myopia progression, which is an area of ​​ongoing research by the present inventors, will be clarified.

[0007] The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide a light irradiation device, a light irradiation system, and a method for operating a light irradiation device that can irradiate the eye with light to effectively express the OPN5 gene or activate OPN5.

[0008] (1) The light irradiation device of the present invention is a light irradiation device that irradiates light onto the eye to express the OPN5 gene or activate OPN5, and is characterized in that it has a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5, and the irradiation conditions of the light irradiated from the light source are set to express the OPN5 gene or activate OPN5.

[0009] According to this invention, light emitted from a light source is irradiated toward the eye, and since the light has a wavelength range that overlaps with the absorption spectrum of OPN5 (peak wavelength: approximately 380 nm), it is possible to express the OPN5 gene present in the retina or activate OPN5. Note that since OPN5 is present in the retina, the light is irradiated toward the eye, but it is more preferable to irradiate the eye directly, which can more effectively express the OPN5 gene or activate OPN5. The greater the wavelength overlap between the spectral data of the light and the OPN5 absorption spectral data, the more the light is absorbed by OPN5.

[0010] In the light irradiation device according to the present invention, the setting can be performed based on the results of comparing the spectral data of the light obtained by receiving the light irradiated from the light source with the absorption spectral data of the OPN5 in advance or on the spot.

[0011] According to this invention, the actual light spectrum data obtained by receiving light irradiated from a light source is compared in advance or in situ with the absorption spectrum data of OPN5, and the light irradiation conditions are set based on the results of the comparison, thereby making it possible to more effectively express the OPN5 gene or activate OPN5.

[0012] In the light irradiation device according to the present invention, the spectrum of the light obtained by receiving the light irradiated from the light source is a spectral irradiance (W / m) of the light in a wavelength range of 280 to 500 nm. ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is the spectral irradiance (W / m ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is set to be 0.2% or more of the maximum value.

[0013] According to this invention, the spectrum of light received by the irradiated body is set so that the received effective spectral irradiance is 0.2% or more of the maximum reference effective spectral irradiance. In this light irradiation device, the spectrum of light received by the irradiated body may be determined by appropriately selecting a light source that emits light in a wavelength range overlapping the peak wavelength of the OPN5 absorption spectrum based on the technical common sense of a person skilled in the art, so that the received effective spectral irradiance is 0.2% or more of the reference effective spectral irradiance. One or more of the light irradiation direction, light wavelength range, light irradiance, light irradiation time period, and light irradiation duration may be adjusted. As a result, the OPN5 gene can be expressed or OPN5 can be activated more effectively. The light that achieves a ratio within the above range is calculated based on the light spectrum measured at the irradiated body or at a position around the irradiated body.

[0014] As an example of a modified example of the light irradiation device, one or more light sources are provided that irradiate light with wavelengths in a wavelength range that overlaps with the peak wavelength of the OPN5 absorption spectrum, and the spectrum of the light received by the irradiated object is determined by the spectral irradiance (W / m) of each wavelength in the wavelength range of 280 nm to 500 nm of the light. ２ / nm) and the relative absorbance of the OPN5 absorption spectrum data for each wavelength. ２ / nm) in the wavelength range and obtain the effective irradiance (W / m ２ ) is the spectral irradiance (W / m) of the solar spectrum specified in AM1.5G. ２ / nm) and the relative absorbance of the OPN5 absorption spectrum, ２ / nm) in the wavelength range, and the reference effective irradiance (W / m ２ ) is set to 0.2% or more of the light irradiation device.

[0015] Furthermore, as a modified example of the light irradiation device different from the above, one or more light sources are provided which irradiate light in a wavelength range overlapping with the peak wavelength of the OPN5 absorption spectrum, and the spectrum of the light received by the irradiated object is a spectral irradiance (W / m) of each wavelength in the wavelength range of 280 nm to 500 nm of the light. ２ / nm) and the relative absorbance of the OPN5 absorption spectrum data for each wavelength. ２ / nm), and the effective irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the effective dose (J / m ２ ) is the spectral irradiance (W / m) of the solar spectrum specified in AM1.5G. ２ / nm) and the relative absorbance of the OPN5 absorption spectrum, ２ / nm), and the reference effective irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the reference effective dose (J / m ２) is set to 0.2% or more of the light irradiation device.

[0016] In the light irradiation device according to the present invention, the irradiation conditions are one or more selected from the irradiation direction of the light, the wavelength range of the light, the wavelength form of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light.

[0017] According to this invention, the irradiation conditions are one or more selected from the light irradiation direction, the light wavelength range, the light wavelength form, the light irradiance, the light irradiation time period, and the light irradiation duration, so that one or more conditions that can effectively express the OPN5 gene or activate OPN5 can be set depending on the form of light emitted from the light source toward the eye. A preferred embodiment of the setting is an embodiment in which one or more selected from the light irradiation direction, the light wavelength range, the light wavelength form, the light irradiance, the light irradiation time period, and the light irradiation duration are adjusted.

[0018] In the light irradiation device according to the present invention, the irradiation conditions of the light emitted from the light source are set by a light setting section that is provided together with the light source or that is provided separately.

[0019] According to this invention, the irradiation conditions of the light emitted from the light source are set by a light setting unit that is provided together with the light source or separately, and the light setting unit can set the conditions based on the comparison results. As a result, settings according to the irradiation purpose, etc. can be made by the light irradiation device or a separate device. Note that if the light irradiation device does not have a light setting unit, settings according to the irradiation purpose, etc. can be made by a control device (such as a mobile communication terminal such as a smartphone equipped with a control computer, or a central control device) connected wirelessly or wired as a separate device. This setting also includes, for example, setting firmware, for example, during the manufacturing stage, to provide the light irradiation conditions if it is known in advance that the device will be used for a specific irradiation purpose.

[0020] In the light irradiation device according to the present invention, the light irradiation conditions are set based on the results of the comparison and in accordance with the predetermined expression level of the OPN5 gene or the activation level of OPN5.

[0021] According to this invention, the light irradiation conditions are set according to the expression level of the OPN5 gene or the activation level of OPN5 that are predetermined based on the comparison results, and are therefore set according to the expression level of the OPN5 gene or the activation level of OPN5 that are predetermined in the environment in which the light irradiation device is installed. As a result, effective irradiation according to the irradiation purpose, etc. can be performed in the environment in which the light irradiation device is installed. Note that, although the "compared results" mentioned above include pre-compared results and in-situ (in-situ) comparison results, it may be difficult to pre-determine the results of in-situ comparisons, and therefore, here, it refers to the "pre-compared results."

[0022] In the light irradiation device according to the present invention, the light is preferably light of 360 to 400 nm that overlaps with the absorption spectrum of OPN5.

[0023] According to this invention, light in the range of 360 to 400 nm overlaps mainly with the absorption spectrum of OPN5 (peak wavelength: approximately 380 nm), and since light in the range of 360 to 400 nm is not dazzling, it can be irradiated directly onto the eyes, thereby effectively inducing expression of the OPN5 gene or activating OPN5.

[0024] In the light irradiation device of the present invention, the light source is positioned at a position selected from a position where the light is irradiated directly toward the eye, a position where the light enters the field of view, a position in the direction of the line of sight, a position where the light is irradiated to the eye as diffused light diffused by a diffusing material, and a position where the light is irradiated to the eye as reflected light reflected by a reflecting material.

[0025] According to this invention, since light of, for example, 360 to 400 nm is not dazzling, it is desirable to position the light source at a position where the light is irradiated directly toward the eye. On the other hand, even if light is not irradiated directly toward the eye, the light source can be positioned at a position within the field of view or in the line of sight, or at a position where the light is irradiated to the eye as diffused light diffused by a diffusing material, or at a position where a special reflector that reflects light of, for example, 360 to 400 nm is appropriately provided and the light source is irradiated to the eye as reflected light reflected by such a reflector. For example, in desk work, it is desirable to place the light source at a position directly in front of the eye, in the field of view, or in the line of sight. However, even if it is not possible or difficult to place the light at these positions, it is preferable to provide a diffusing material or a reflecting material and diffuse or reflect the light with the diffusing material or the reflecting material to irradiate the eye with diffused light or reflected light. The diffusing material can be selected from various types based on the diffusion angle characteristics and transmittance characteristics, and the reflective material can be a special reflective material that reflects the light that is difficult to reflect, as described above, and can be used in fixed, mobile, or portable types, which has the advantage of increasing the freedom of where the light source can be installed.

[0026] In the light irradiation device of the present invention, (i) when the light source is located at a position where the light is irradiated directly toward the eye, the irradiance of the light is set depending on the distance and / or angle from the light source to the person, (ii) when the light source is located at a position within the field of view or in the line of sight, the irradiance of the light is set depending on the distance and / or angle from the light source to the person, (iii) when the light source is located at a position where the light is irradiated to the eye as diffused light diffused by the diffusing material, the irradiance of the light is set depending on the distance from the light source and the diffusing material to the person and / or the diffusion angle and transmittance of the diffusing material, and (iv) when the light source is located at a position where the light is irradiated to the eye as reflected light reflected by a reflective material, the irradiance of the light is set depending on the distance from the light source and the reflective material to the person and / or the reflectance of the reflective material.

[0027] According to this invention, the irradiance of light is set by each of (i) to (iv), so that light of the necessary irradiance that can express the OPN5 gene in the retina or activate OPN5 can be delivered to a person.

[0028] In the light irradiation device according to the present invention, the light source may be selected from, but is not limited to, a structure-mounted light source mounted on a floor (including underfoot), a wall, a ceiling (including suspended), or other structure; an installation-mounted light source mounted on a desk, table, partition (room divider, screen), shelf, tabletop component, personal computer, display, PC keyboard, television, audio, or other device or installation; a built-in or mountable light source of a portable personal computer, tablet, smartphone, or other mobile terminal; a body-mounted light source mounted on or detachable by attachment to a vision correction device, eye protection device, face protection device, neck hanging device, ear hook, head-mounted device, or other body equipment; and a functional-device-mounted light source mounted on functional equipment for AR, VR, or MR (goggles, headset, or other functional equipment).

[0029] According to this invention, the light source is preferably a light source that can be attached to a structure, equipment, installed object, mobile terminal, body accessory, functional device, etc., and light emitted from such a light source can be effectively irradiated onto a person. As described above, it is desirable to install the light source in a position where the light emitted from the light source is directly irradiated onto the eyes, but in other cases, it is preferable to use a reflector to irradiate the light toward the eyes.

[0030] In the light irradiation device according to the present invention, the orientation or position of the light source is set manually or automatically.

[0031] According to this invention, the orientation or position of the light source can be set manually or automatically, allowing for efficient irradiation of a person either directly or by reflection. As a result, the OPN5 gene in the retina can be expressed or OPN5 can be activated. "Setting the orientation" means setting the orientation by rotating it in any of the three-dimensional X, Y, and Z directions, and "setting the position" means setting the position by moving it in any of the three-dimensional X, Y, and Z directions.

[0032] In one aspect of the light irradiation device according to the present invention, the spectrum of the received light is determined by the spectral irradiance (W / m) of each wavelength in the wavelength range of 280 to 500 nm of the light. ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is the spectral irradiance (W / m) of the absorption spectrum of sunlight specified by AM1.5G ２ / nm) and the relative absorbance of the absorption spectrum of OPN5, ２ / nm).

[0033] According to this invention, the effective spectral irradiance (W / m) of the received light, which is the product of both at each wavelength, is calculated. ２ / nm) is the reference effective spectral irradiance (W / m) which is the product of the spectral irradiance of the absorption spectrum of sunlight specified in AM1.5G and the absorption spectrum of OPN5 for each wavelength. ２ / nm), the actual effective spectral irradiance relative to the common reference effective spectral irradiance can be generalized and evaluated, regardless of the measurement area or measurement time. As a result, it is possible to clarify the objective relationship with the effect of expressing the OPN5 gene in the retina or activating OPN5, and the device can be used to clarify such a relationship.

[0034] In the above aspect, it is preferable that the received light effective spectral irradiance is set to 0.2% or more of the reference effective spectral irradiance.

[0035] In one aspect of this light irradiation device, the light spectrum data and the OPN5 absorption spectrum data may be normalized and then the overlapping portions thereof may be compared. In this case, it is preferable that the overlapping portions are large.

[0036] In the light irradiation device according to the present invention, as one aspect of the comparison, the received light effective spectral irradiance (W / m ２ / nm) is integrated over the wavelength range to be compared to obtain the effective irradiance (W / m ２) is obtained, and the reference effective spectral irradiance (W / m ２ / nm) is similarly integrated to obtain the reference effective irradiance (W / m ２ ) is calculated, and the resulting received effective irradiance is compared with the reference effective irradiance.

[0037] In the above aspect, it is preferable that the received light effective irradiance is set to 0.2% or more of the reference effective irradiance.

[0038] In one aspect of the light irradiation device, the effective irradiance of the received light (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the effective dose (J / m ２ ) and the reference effective irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the reference effective dose (J / m ２ ) may be compared.

[0039] According to this invention, the received effective irradiance is compared with the reference effective irradiance, and the received effective dose (J / m ２ ) and the reference effective dose (J / m ２ ) and the results (for example, percentages) can be used to evaluate the dependency of the light irradiation time on the effect of expressing the OPN5 gene in the retina or activating OPN5.

[0040] In the above aspect, it is preferable that the received effective dose is set to 0.2% or more of the reference received effective dose.

[0041] In the light irradiation device according to the present invention, the measurement during the comparison is performed by a measurement unit. The form of the measurement unit is not particularly limited as long as it is capable of performing the measurement. Non-limiting examples of the measurement unit include, based on the form of the light source that irradiates the light, a measurement unit that is provided in glasses, earphones, a wristwatch, a chest badge, or other item worn on the body, that is worn on the body itself, or that is attached to an installation near or around the body.

[0042] According to this invention, the mounting method in the above manner is arbitrarily selected based on the installation form of the light source that emits light (light source form, light source installation position, etc.), so it is less likely to get in the way and makes it easier to measure the light spectrum data received by the eyes and body.

[0043] In the light irradiation device according to the present invention, the light is flashing light and / or constant light, and the respective irradiation conditions are set by comparing the spectral data of the irradiated light with the absorption spectral data of OPN5 in advance or on the spot, and based on the results of the comparison, the irradiation conditions of the flashing light and / or constant light are set.

[0044] According to this invention, the irradiation conditions for the flashing light and / or constant light are set based on the results of a pre- or on-site comparison between the spectral data of the irradiated light and the absorption spectral data of OPN5, so that irradiation with effective light (flashing light and / or constant light) according to the purpose of irradiation, etc. can be performed in the environment where the light irradiation device is installed, thereby enabling expression of the OPN5 gene or activation of OPN5 in the retina.

[0045] (2) The light irradiation system according to the present invention is characterized in that it is a combination of two or more of the light irradiation devices according to the present invention, or includes two or more light sources constituting the light irradiation device according to the present invention.

[0046] According to this invention, a light irradiation system combining two or more light irradiation devices or a light irradiation system combining two or more light sources equipped in a light irradiation device can be configured. In a light irradiation system combining two or more light irradiation devices, each with its own set of irradiation conditions, a system can be configured in which each light irradiation device has its own role (illumination purpose). As a result, for example, light irradiation devices with their own roles can be placed in positions corresponding to indoor activities and behavioral patterns. Furthermore, in a light irradiation system including two or more light sources constituting a light irradiation device, irradiation conditions corresponding to the role of each light source can be set so that each light source plays a role (illumination purpose) to achieve a specific purpose, thereby configuring a system that achieves overall uniformity. As a result, for example, light set to achieve a specific purpose can be placed in positions corresponding to indoor activities and behavioral patterns.

[0047] (3) A method for operating a light irradiation device according to the present invention is a method for operating a light irradiation device that irradiates light onto an eye to express the OPN5 gene or activate OPN5, and is characterized by comprising: a light source arrangement step of arranging a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5; a light data comparison step of comparing in advance or on the spot the spectral data of the light obtained by receiving the light irradiated from the light source arranged in the light source arrangement step with the absorption spectral data of OPN5; and a light setting step of setting the light irradiation conditions based on the results of the comparison in the light data comparison step to express the OPN5 gene or activate OPN5.

[0048] According to this invention, particularly in the light setting step, the irradiation conditions of light irradiated from the light source are set based on the results of the comparison in the light data comparison step to express the OPN5 gene or activate OPN5, thereby enabling settings to be made according to the irradiation purpose, etc. Note that this light setting step may be performed by the light irradiation device or by a separate device. If performed by a separate device, the light setting step is performed by a control device (such as a mobile communication terminal such as a smartphone equipped with a control computer, or a central control device) connected wirelessly or via a cable, allowing settings to be made according to the irradiation purpose, etc. Furthermore, the setting in this light setting step may also include, for example, setting firmware during the manufacturing stage to provide the light irradiation conditions, if the use for a specific irradiation purpose is known in advance.

[0049] In the method for operating a light irradiation device according to the present invention, the light irradiation conditions set in the light setting step are one or more conditions selected from the installation position of the light source, the irradiation direction of the light, the wavelength range of the light, the wavelength form of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation duration of the light.

[0050] In the method for operating a light irradiation device according to the present invention, the light is light of 360 to 400 nm that overlaps with the absorption spectrum of OPN5.

[0051] According to the present invention, it is possible to provide a light irradiation device, a light irradiation system, and a method for operating a light irradiation device that can effectively activate OPN5 in the retina of the eye with light.

[0052] In particular, with the light irradiation device and its operating method according to the present invention, light emitted from a light source is irradiated toward the eye, and the light is in a wavelength range that overlaps with the peak wavelength (approximately 380 nm) of the absorption spectrum of OPN5, thereby expressing the OPN5 gene present in the retina or activating OPN5. Moreover, the light source compares in advance or on-site the spectral data of the actual light obtained by receiving the irradiated light with the absorption spectral data of OPN5, and the light irradiation conditions are set based on the results of the comparison, thereby more effectively expressing the OPN5 gene or activating OPN5.

[0053] According to the light irradiation system of the present invention, a light irradiation system combining two or more light irradiation devices, each with its own irradiation conditions, can be configured with a system in which each light irradiation device has its own role (illumination purpose). As a result, for example, light irradiation devices with their own roles can be placed in positions corresponding to indoor activities and behavioral patterns. Furthermore, in a light irradiation system including two or more light sources constituting a light irradiation device, irradiation conditions corresponding to the role of each light source can be set so that each light source plays a role (illumination purpose) to achieve a specific purpose, thereby configuring a system that achieves overall uniformity. As a result, for example, light set to achieve a specific purpose can be placed in positions corresponding to indoor activities and behavioral patterns.

[0054] This figure shows the absorbance (dimensionless) of the absorption spectrum of OPN5. This figure shows the absorption spectra of OPN5, OPN4, rhodopsin (Rh), and three photopsins (S, M, L). This figure shows the standard relative luminosity for photopic vision at each wavelength (top panel) and the color of light (bottom panel). This figure shows an example of a violet light LED with an irradiation wavelength range of 360 to 400 nm. (A) shows an example of a light source that irradiates light over a wide wavelength range, including wavelengths over 400 nm. (B) shows an example in which the wavelength range of the irradiated light is limited to 360 to 400 nm using a blocking filter. (C) shows the overlap between the irradiated light limited by (B) and the absorption spectrum of OPN5. This figure shows an example of a light source installation in a large office space. This figure shows an example of a light source installation in a home or office. This figure shows an example of a desktop light source on a desk and a computer-mounted light source. (A) is the absorbance (dimensionless) of the absorption spectrum of OPN5, (B) is the spectral irradiance of a violet light LED with a peak at 375 nm, and (C) is the received effective spectral irradiance, which is the product of both at each wavelength. (A) is the absorbance (dimensionless) of the absorption spectrum of OPN5, (B) is the spectral irradiance of a broadband light source emitting light of 300 nm or longer, and (C) is the received effective spectral irradiance, which is the product of both at each wavelength. (A) is the absorbance (dimensionless) of the absorption spectrum of OPN5, (B) is the spectral irradiance of the absorption spectrum of sunlight specified in AM1.5G, and (C) is the reference effective spectral irradiance, which is the product of both at each wavelength. The reference effective spectral irradiance (symbol b) shown in Figure 11(C) is compared with the received effective spectral irradiance (symbol a) shown in Figure 9(C). 1 is a schematic diagram showing an example of a light irradiation device. FIG. 2 is an explanatory diagram of the activation mechanism of OPN5.

[0055] The light irradiation device, light irradiation system, and operating method of the light irradiation device according to the present invention will be described below with reference to the drawings. The present invention is not limited to the following embodiments as long as it includes the gist of the present application, and can be modified into various forms. In this specification, the meaning of "setting" includes "adjustment" or "regulation" as one of its forms. "To be set" includes the meanings of "can be set" and "already set," but can also be divided into the two expressions expressing the respective meanings.

[0056] [Light Irradiation Device] The light irradiation device of the present invention is a light irradiation device that irradiates light onto the eye to express the OPN5 gene or activate OPN5, and is characterized in that it has a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5, and the irradiation conditions for the light irradiated from the light source are set to express the OPN5 gene or activate OPN5.

[0057] In this light irradiation device, light emitted from a light source is irradiated toward the eye, and since the light is in a wavelength range that overlaps with the absorption spectrum of OPN5 (peak wavelength: approximately 380 nm), it is possible to express the OPN5 gene present in the retina or activate OPN5. Note that since OPN5 is present in the retina, the light is irradiated toward the eye, but it is more preferable to irradiate the eye directly, which can more effectively express the OPN5 gene or activate OPN5.

[0058] In this light irradiation device, the setting can be performed based on the results of comparing in advance or in situ the spectral data of the light obtained by receiving the light irradiated from the light source with the absorption spectral data of OPN5, thereby more effectively expressing the OPN5 gene or activating OPN5.

[0059] In this light irradiation device, the spectrum of the light received from the light source is determined by the spectral irradiance (W / m) of the light in the wavelength range of 280 to 500 nm. ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is the spectral irradiance (W / m ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm). This allows the OPN5 gene to be expressed or OPN5 to be activated more effectively. The light having a ratio within the above range is calculated based on the spectrum of light measured at or near the irradiated object.

[0060] Each component will be described in detail.

[0061] <OPN5, OPN5 Absorption Spectrum> OPN5 (opsin 5) is a photoreceptor protein present in the human retina. As shown in Figure 1, OPN5 exhibits an absorption spectrum with a peak at 380 nm. In the present invention, the "OPN5 absorption spectrum" is defined as the absorption spectrum of OPN5 shown in Figure 1. Figure 1 is taken from Fig. 5A in "Kojima D, Mori S, Torii M, Wada A, Morishita R, et al. (2011) UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice. PLoS ONE 6(10): e26388. doi:10.1371 / journal.pone.0026388" and is understood as standard by those skilled in the art at the time of filing this application. Furthermore, the absorption spectrum of OPN5, which has an absorption peak at 380 nm, is also clearly stated in the cited document and is understood by those skilled in the art. Light irradiation according to the present invention is expected to induce expression or activation of the OPN5 gene present in the retina of the irradiated subject, which is expected to lead to the treatment and symptom improvement of various diseases, the improvement of visual and non-visual functions, the inhibition of myopia progression, and the exploration and development of related research. Figure 2 shows the absorption spectra of OPN5, OPN4, rhodopsin (Rh), and three photopsins (S, M, L). This is also shown in Fig. 5A of the aforementioned reference by Kojima et al. OPN5 is located in the lowest wavelength range among these.

[0062] 1 , when the absorbance at the peak at 380 nm is taken as 1, the absorption spectrum of OPN5 has the following wavelength ranges: an absorbance of 0.1 or more is in the range of about 300 to about 440 nm, an absorbance of 0.5 or more is in the range of about 340 to about 420 nm, an absorbance of 0.7 or more is in the range of about 350 to about 410 nm, and an absorbance of 0.8 or more is in the range of about 360 to about 400 nm. For OPN5 having such absorbance characteristics, it is preferable to irradiate it with light having a light spectrum in a wavelength range showing high absorbance, in order to effectively express the OPN5 gene or activate OPN5.

[0063] <Light> The light is emitted from a light source and has a wavelength range that overlaps with at least a portion of the wavelength range of the absorption spectrum of OPN5. Here, "at least a portion of the wavelength range of the absorption spectrum of OPN5" means that the light may overlap with the entire wavelength range of the absorption spectrum of OPN5 shown in FIG. 1 or may overlap with only a portion of the wavelength range. "The entire wavelength range of the absorption spectrum of OPN5" is the range of approximately 270 to 500 nm, as shown in FIG. 1. As described above, examples of "a portion of the absorption spectrum of OPN5" include a wavelength range (approximately 300 to approximately 440 nm) with an absorbance of 0.1 or more, a wavelength range (approximately 340 to approximately 420 nm) with an absorbance of 0.5 or more, a wavelength range (approximately 350 to approximately 410 nm) with an absorbance of 0.7 or more, and a wavelength range (approximately 360 to approximately 400 nm) with an absorbance of 0.8 or more. As light that effectively solves the problems of the present invention, violet light of 360 to 400 nm, which overlaps with the wavelength range (approximately 360 to 400 nm) in which the absorbance of the absorption spectrum of OPN5 is 0.8 or more, is desirable.

[0064] (Light Wavelength Range) Since light of less than 315 nm is said to be harmful to the eyes of humans, the lower limit wavelength of light is preferably 340 nm, 350 nm, or 360 nm. Which of these wavelengths is set as the lower limit depends on the irradiance of light in that lower limit region. Therefore, if the irradiance of light near the lower limit is low, 340 nm may be used. However, light having a lower limit range of 350 nm, and more preferably 360 nm, is preferred. In the absorption spectrum of OPN5 shown in FIG. 1 , the absorbance is 0.7 or higher in the wavelength range of about 350 to about 410 nm and 0.8 or higher in the wavelength range of about 360 to about 400 nm. Therefore, employing a light source that primarily irradiates light in the wavelength range of about 350 to about 410 nm or about 360 to 400 nm can contribute to the expression of the OPN5 gene or the activation of OPN5.

[0065] The light is preferably light with an upper wavelength limit of 400 nm or less or 410 nm or less. Light of such wavelengths has a low relative luminous efficiency. Light with a low relative luminous efficiency is non-dazzling and / or non-bright light. "Non-dazzling light" refers to light that is not dazzling to the irradiated subject, and since such light does not or only rarely perceives glare, it is advantageous in that it allows for long-term irradiation of the subject. "Non-bright light" refers to light with low illuminance. "Irradiation of light with a wavelength of 400 nm or less or 410 nm or less with a low relative luminous efficiency" can include irradiation from a light source that does not emit or substantially does not emit light greater than 400 nm or greater than 410 nm, and such light sources are particularly preferably violet light of 360 to 400 nm or light of 350 to 410 nm. Furthermore, even when light is irradiated from a light source equipped with a filter that blocks light with wavelengths greater than 400 nm or greater than 410 nm, or when light with wavelengths greater than 400 nm or greater than 410 nm is emitted, light with wavelengths of 400 nm or less or 410 nm or less can be irradiated.

[0066] Regarding relative luminous efficiency, for example, "Masanori Takase, Katsunori Okajima, Keiji Uchikawa, and Mitsuo Ikeda, 'Changes in Brightness of Colored Light During Direct Comparison,' Optics, Vol. 19 (No. 3), published in 1990," describes that it can be measured by the direct comparison method, cross illumination method, sequential method, MDB method, absolute threshold method, etc., and that the CIE standard relative luminous efficiency function is mainly determined by the cross illumination method, and is generally evaluated by the direct comparison method and the cross illumination method. Note that data on relative luminous efficiency (spectral luminous efficiency) is listed in Appendix 8 of "https: / / laws.e-gov.go.jp / download?law_unique_id=404M50000400080_20161001_000000000000000&file_type=PDF_H1." Relative luminous efficiency (relative luminous efficiency in a bright place) is standardized for light with a wavelength of 555 nm (green light). From this table, for example, a relative luminous efficiency of 0.01 or less corresponds to a wavelength range of less than 430 nm on the short wavelength side. Thus, humans perceive green light as the brightest, and the perception of brightness decreases as the wavelength increases or decreases. Relative luminous efficiency is expressed as a comparative value, with the brightness of a wavelength of 555 nm set to 1, relative to the brightness of other wavelengths with the same energy. Figure 3 shows the standard relative luminous efficiency for photopic vision. Because the degree to which light is perceived as non-glare varies from person to person, it is difficult to determine the relative values ​​on the vertical axis shown in Figure 3. However, light with wavelengths of 400 nm or less or 410 nm or less has a shorter wavelength than the wavelength range of less than 430 nm, where the relative luminous efficiency is 0.01 or less, and therefore has an even smaller relative luminous efficiency, at least less than 0.01. Light with wavelengths of 400 nm or less or 410 nm or less, which exhibits such extremely small relative luminous efficiency values, can be said to be less dazzling than light in other wavelength ranges with a relative luminous efficiency exceeding 0.01, regardless of individual differences. As a result, this light is advantageous in that it can be irradiated directly onto a person or for a long period of time without causing glare to the person. Note that, in this application, the terms "irradiated object" and "person" or "human eye" have the same meaning and can be used interchangeably. Such light has a large overlap with the absorption spectrum of OPN5 and is not dazzling, so it is not bothersome even when it enters the eye, and can, for example, express the OPN5 gene present in the retina or activate OPN5.

[0067] As described above, in the absorption spectrum of OPN5 shown in Figure 1, the absorbance is 0.7 or higher in the wavelength range of approximately 350 to 410 nm, and the absorbance is 0.8 or higher in the wavelength range of approximately 360 to 400 nm, so employing a light source that mainly irradiates light in the wavelength range of 350 to 410 nm or 360 to 400 nm can contribute to the activation of OPN5. Note that the inventors refer to light in the wavelength range of 360 to 400 nm as violet light, and so light in these wavelength ranges will hereinafter be referred to as "violet light."

[0068] <OPN5 Gene Expression or OPN5 Activation> With regard to OPN5 gene expression, prior art document WO2020 / 027305A1, which includes a publication by the present inventor, describes that OPN5 gene expression can be quantified and that such quantification can be used to evaluate the level of gene expression. As described above, the evaluation is performed by using a comparison reference value when no light of 360 to 400 nm is irradiated, at which the absorbance of the OPN5 absorption spectrum is 0.8 or higher, and evaluating the degree of gene expression from this comparison reference value as the OPN5 gene expression level. Desired irradiation conditions and the installation position of the light source can be determined by comprehensively evaluating the irradiation conditions and the effects on diseases. The light irradiation device according to the present invention is expected to be effective against a variety of diseases by determining the irradiation conditions and the installation position of the light source when irradiating the retina with light from the perspective of expressing the OPN5 gene.

[0069] OPN5 activation can also be evaluated in the same way as OPN5 gene expression. Incidentally, in evaluating OPN5 activation, the degree of activation can be evaluated by measuring electroencephalograms in response to light irradiation. In fact, similar prior art documents (WO2020 / 027305A1 and https: / / www.mdpi.com / 2075-4426 / 11 / 6 / 557) also show specific brain activity (electroencephalograms) upon irradiation with light of 360 to 400 nm, so OPN5 activation can be evaluated by the generation of electroencephalograms. Since OPN5 is a photoreceptor known as Gi-type GPCR, when measuring activity at the cellular level, cells are cultured and exposed to light, and K ＋The increase in intracellular levels of ions and the increase in cAMP are measured. ＋ The paper (https: / / www.pnas.org / doi / 10.1073 / pnas.1012498107) also describes that OPN5 inflow, which increases intracellular cAMP and raises the signal. The light irradiation device according to the present invention is expected to be effective against a variety of diseases by determining the irradiation conditions and light source installation position when irradiating the retina with light from the perspective of activating OPN5.

[0070] OPN5 activation by irradiation with light with wavelengths of 360-400 nm is achieved by activating the OPN5 protein in retinal ganglion cells in the retina, transmitting stimuli to the central brain, and increasing myelin, thereby increasing the efficiency of neurotransmission, as shown in Figure 14. This mechanism is also introduced in the inventor's paper (Violet light modulates the central nervous system to regulate memory and mood, https: / / www.biorxiv.org / content / 10.1101 / 2021.11.02.466604v1). Myelin is important for the appropriate transmission of neural signals in the brain, and is known to be related to various brain functions and brain functional diseases such as dementia, depression, sleep, and Parkinson's disease. Therefore, the present invention can increase myelin and improve the efficiency of neurotransmission by irradiating light in the wavelength range of 360 to 400 nm. When irradiating the retina with light and determining the installation position of the light source, by implementing the invention from the perspective of activating OPN5, it is expected that the invention will be effective against a variety of diseases.

[0071] <Light Source> The light source is not particularly limited as long as it irradiates light in the wavelength range described above. "Irradiating light in the wavelength range" refers to a light source whose emission spectrum itself has the wavelength range described above (e.g., light from 360 to 400 nm or 350 to 410 nm). Alternatively, the light source may emit light within the wavelength range described above even if its emission spectrum exceeds the upper limit of the wavelength range described above by using a blocking filter. When primarily irradiating non-glare light within the wavelength range, a light source that does not emit or substantially does not emit light with wavelengths exceeding 400 nm (e.g., a violet light LED light source with a peak wavelength at 375 nm) may be used, as shown in FIG. 4 . Alternatively, for a light source that irradiates light in a wide wavelength range, including wavelengths exceeding 400 nm, as shown in FIG. 5(A), a light source equipped with a blocking filter as shown in FIG. 5(B) may be used. Note that FIG. 5(B) shows an example of a light source in which the wavelength range of the irradiated light is limited to 360 to 400 nm using a blocking filter, and FIG. 5(C) is an explanatory diagram showing the overlap between the light irradiated from the light source and the absorption spectrum of OPN5.

[0072] For example, light of 360 to 400 nm or 350 to 410 nm overlaps largely with the absorption spectrum of OPN5, which has a peak at 380 nm, and has a small relative luminous efficiency and is not dazzling. Therefore, even if the light is irradiated onto the eye as direct light, diffused light, or reflected light, it is relatively unnoticeable, and can express the OPN5 gene present in the retina or activate OPN5, for example.

[0073] More preferably, the light source is a light source that emits light that primarily overlaps with the range of 380 nm ±20 nm, which is the peak wavelength of the absorption spectrum of OPN5. A light source that emits such light can express the OPN5 gene or activate OPN5 by irradiating light of 360 to 400 nm, which primarily overlaps with the range of 380 nm ±20 nm. "Light that primarily overlaps" may be light having an emission spectrum with a peak within the range of 380 nm ±20 nm, as shown in FIG. 4, for example, or light that does not have a peak within the range of 380 nm ±20 nm, as shown in FIG. 5(A), but has an emission spectrum that exhibits strong spectral irradiance within that range. With such a light source, the light irradiated from the light source and the absorption spectrum of OPN5 primarily overlap, as shown in FIG. 5(C), for example.

[0074] <Installation form of light source> One or more light sources are provided. The light source is preferably an indoor-installed light source, such as a light source directly installed in a building such as a house or room of an ordinary household, a school building or classroom, a government building, a company building, an office or workshop, a gymnasium or an indoor sports field, or a building that is covered with a roof but has no walls, or a light source attached to furniture or an installed object. Alternatively, the light source may be a portable light source that can be carried by a person or a light source that can be worn by a person.

[0075] Examples of portable light sources that can be carried by a person include light sources that can be attached to mobile terminals such as portable personal computers, tablets, and smartphones, and examples of light sources that can be worn by a person include light sources attached to vision correction devices, eye protection devices, face protection devices, neck hanging devices, ear hooks, head attachment devices, etc. Note that the light sources that can be worn by a person may be eyeglass-mounted light sources in which a light source is attached to eyeglasses that can be worn by a person regardless of whether they have a vision correction function, attachment light sources that can be attached and detached to such eyeglasses, or light sources attached to goggle-type devices for functional, AR, VR, and MR purposes.

[0076] The light source may be selected from the following: a structure-mounted light source attached to a floor (including underfoot), a wall, a ceiling (including hanging), or other structure; an installation-mounted light source attached to a desk, table, partition (room divider, screen), shelf, tabletop component, personal computer, display, PC keyboard, television, audio, or other device or installation; a built-in or installation-mounted light source for a portable personal computer, tablet, smartphone, or other mobile terminal; a body-mounted light source attached to or detachable by attachment to a vision correction device, eye protection device, face protection device, neck hanging device, ear hook, head-mounted device, or other body equipment; and a functional device-mounted light source attached to functional equipment for AR, VR, or MR (goggles, headset, or other functional equipment). Depending on the installation form, the light source is preferably an installation-mounted light source for a structure, installation, device, mobile terminal, etc., a body-mounted light source, or a functional device-mounted light source, and the light emitted from the light source can be irradiated to a person as direct light, diffused light, or reflected light. 6 to 8 show examples of light source installation, with Fig. 6 showing an example of a light source installation in a large office space, Fig. 7 showing an example of a light source installation in a home or office, and Fig. 8 showing an example of a desktop light source or a light source installed on a computer. In this way, light sources can be installed in a variety of ways.

[0077] The term "one or more light sources" means one or more light sources selected from the various light sources described above (installed light sources, body accessory light sources, and functional device installed light sources). When there is one light source, it is desirable that the light emitted from the light source be positioned so that it is directed toward the eyes.

[0078] As a specific installation form of the stationary light source, for example, as shown in Figures 6 and 7 , when the direction of the line of sight does not change much, such as when mainly doing desk work in an office or studying at school, a study room, or at home, it is desirable to place the stationary light source 10 at the line of sight and orient the stationary light source 10 so that light is emitted toward the eye direction D. Also, in Figures 6 and 7 , the light source 10 is placed at a position within the field of view or in the line of sight, and the light source 10 may be placed at such a position. Furthermore, even if the light source 10 is not facing the person, the light source 10 may be placed at a position (e.g., outside the field of view or outside the line of sight) where light can be irradiated onto the eye using a diffusing material or a reflecting material 11 (see Figures 6 and 7 ). In this way, one or more light sources 10 can be provided in various positions. 6 and 7 show examples of a stationary light source in which the light source 10 is mainly attached to a wall or ceiling, or to a desk, table, or floor (including underfoot), but the light source 10 may also be attached to other structures, or to a partition (room divider, screen), shelf, tabletop component, or other installed object. Furthermore, as shown in Fig. 8, it is desirable that the light source 10 be oriented in a position within the field of view or in the line of sight, for example, on the frame of a display or an extension thereof, or beside the keyboard of a personal computer.

[0079] Furthermore, as shown in Figure 7, in cases where the direction of the line of sight may change at work, at home, etc., it is desirable to arrange two or more installed light sources 10 and set the positions and orientations of the light sources 10 so that light is emitted as close to the eyes as possible. For example, if a person often sits on a chair or sofa, it is desirable to arrange the installed light source 10 as close to eye height as possible and to install the light source so that it is directed as close to the eyes as possible at that height. Similarly, in cases where a person often stands, it is desirable to arrange the installed light source 10 as close to eye height as possible and to install the light source so that it is directed as close to the eyes as possible at that height. Note that when a person sits and stands, it is desirable to arrange the installed light source 10 so that it satisfies both situations and to install the installed light source 10 so that it is directed as close to the eyes as possible at each height.

[0080] Since the above-mentioned light (e.g., light with a wavelength of approximately 400 nm or less) is usually difficult to reflect, it is desirable to position the light source at a position where the light is directly irradiated toward the eye, as described above. On the other hand, even if the light is not directly irradiated toward the eye, the light source can be positioned in the following ways: a) at a position within the field of view or in the line of sight; b) at a position where the light is irradiated toward the eye as diffused light diffused by a diffusing material; or c) at a position where a special reflector that reflects light with a wavelength of 400 nm or less is appropriately provided and the light source is irradiated toward the eye as reflected light reflected by such a reflector. For example, in desk work, it is desirable to place the light source directly in front of the eye, in the field of view, or in the line of sight. However, if it is not possible or difficult to place the light in these positions, or if sunlight is the light source and the materials of the walls and floors of the room do not easily reflect or diffuse the light and prevent it from entering the room, it is preferable to use a suitable diffusing material or reflecting material to diffuse or reflect the light and irradiate the diffused light or reflected light toward the eye. It is preferable to irradiate the eye with light by using one or more of these means in combination. The diffusing material can be selected from various types based on the diffusion angle characteristics and transmittance characteristics, and the reflective material can be a special reflective material that reflects the light that is difficult to reflect, as described above, and can be used in fixed, mobile, or portable types, which has the advantage of increasing the freedom of where the light source can be installed.

[0081] It is preferable that the stationary light source is pre-installed so that the light is directed toward the eyes, or installed at a position that is within the field of view or in the line of sight. The installation position of the light source may be changed manually or automatically, and the angle of light emitted from the light source may be changed manually or automatically. It is also effective to equip the light source with a tracking system that detects the human eye or human movement and irradiates light accordingly. It is also effective to swing the light source in various directions or to use a light source with a wide light emission angle. When using a diffusing material or a reflective material, the light source position may be changed, or the type of diffusing material or the installation angle of the reflective material may be changed.

[0082] Examples of the mobile device-mounted light source include a light source attached to a mobile device such as a portable personal computer, tablet, or smartphone, but may also be a light source that can be attached to other mobile devices. Like the fixed light source, the mobile device-mounted light source is preferably pre-installed so that the light is directed toward the eye. The installation position of the light source may be changed manually or automatically, and the angle of the light emitted from the light source may be changed manually or automatically. As with the above, it is also effective to equip the light source with a tracking system, and it is also effective to swing the light source in various directions or use a light source with a wide light emission angle.

[0083] Examples of body-attached light sources include attachment light sources that can be attached or detached to vision correction devices, eye protection devices, face protection devices, neck hanging devices, ear hooks, head attachment devices, etc., but other light sources may also be used as long as they are attachable to the body. As with the above-mentioned light sources, it is preferable that the body-attached light source is also pre-installed so that the light is directed toward the eyes. Note that, since the body-attached light source is closer to the eyes, it does not require changing its installation position compared to the above-mentioned light sources, but it may be changed manually or automatically as needed, and the angle of the light emitted from the light source may be changed manually or automatically.

[0084] The functional device-mounted light source is a light source attached to functional devices (goggles, headsets, etc.) for AR, VR, MR, etc., but may also be a light source that can be attached to other devices. Like the above-mentioned body-accessory light source, the functional device-mounted light source is close to the eye, so it does not need to be installed at a different position than the above-mentioned light sources, but it may be manually or automatically changed as needed, and the angle of the light emitted from the light source may be changed manually or automatically.

[0085] <Irradiation Form> Light emitted from a light source is irradiated toward a person, particularly preferably toward the eyes. "Irradiated" means that light emitted from a light source is irradiated toward a person. The light source may be aimed at the person and the light emitted from the light source may be directly irradiated toward the person, or light emitted from a light source at a position within the field of view or in the line of sight may be irradiated, or light emitted from a light source may be irradiated as diffused light or reflected light even if the light source is not aimed at the person. "Direct or reflected" means that the light source may be directly irradiated toward the person (preferably the eye) or may be irradiated after being reflected by a reflector. "Direct irradiation" also includes light diffused by a diffusing material and irradiated toward the eye. The orientation or position of the light source may be set manually or automatically. This allows the orientation or position of the light source to be set manually or automatically, thereby allowing for efficient irradiation toward the person directly or by reflection. As a result, the OPN5 gene can be expressed or OPN5 can be activated. "Setting the orientation" means setting it by rotating it arbitrarily in each of the three-dimensional X, Y, and Z directions, and "setting the position" means setting it by moving it arbitrarily in each of the three-dimensional X, Y, and Z directions.

[0086] In such a light irradiation device, it is preferable that (i) when the light source is located at a position where light is irradiated directly toward the eye, the irradiance of the light is set depending on the distance and / or angle from the light source to the person, (ii) when the light source is located at a position within the field of view or in the line of sight, the irradiance of the light is set depending on the distance and / or angle from the light source to the person, (iii) when the light source is located at a position where the light is irradiated to the eye as diffused light diffused by a diffusing material, the irradiance of the light is set depending on the distance from the light source and the diffusing material to the person and / or the diffusion angle and transmittance of the diffusing material, and (iv) when the light source is located at a position where the light is irradiated to the eye as reflected light reflected by a reflective material, the irradiance of the light is set depending on the distance from the light source and the reflective material to the person and / or the reflectance of the reflective material. Since the irradiance of the light is set depending on each of (i) to (iv), it is possible to deliver light of the irradiance required to express the OPN5 gene or activate OPN5 to the person.

[0087] (Reflective material) A reflective material is a material that reflects violet light in a specific direction. Violet light is not reflected by reflective materials that reflect normal white light. Therefore, by providing a special reflective material that reflects violet light, the violet light can be reflected by the reflective material and directed toward a person even when the violet light is not directed directly toward a person, when direct irradiation is not possible due to installation reasons, or when the person is located far from the light source (for example, sunlight) (a position farther back from a window in a room than sunlight).

[0088] When the light source cannot be placed in a position where it can be irradiated directly onto the eyes due to the circumstances surrounding the light source installation, it is possible to irradiate the reflected light toward the eyes by placing the above-mentioned special reflector in an appropriate position. For example, in the desk work shown in Figure 6, it is desirable to place the light source 10 in front of the eyes. However, if the light source cannot be placed in front of the eyes, it is preferable to place a reflector 11 in front of the eyes and use the reflector 11 to reflect the light toward the eyes. The reflector 11 in Figure 6 is an example of a reflector that reflects light from a light source suspended from the ceiling toward the eyes. Using a fixed, mobile, or portable reflector as the reflector has the advantage of increasing the flexibility of the light source installation location. As such, it is desirable to place the light source in a position where the light emitted from the light source can be irradiated directly onto the eyes, but in other cases, it is preferable to use a reflector to irradiate the light toward the eyes.

[0089] The reflective material can be installed by applying a resist ink to a plate or wall. Specific examples include a highly ultraviolet reflective white resist ink manufactured by Okamoto Glass Co., Ltd. A reflective material formed by applying the white resist ink to a thickness of 20 μm on a glass substrate can be used to illuminate an NSPU510CS (bullet-type LED, peak wavelength: 375 nm) manufactured by Nichia Corporation at a distance of 10 cm from the reflective material, with an output of 69 μW / cm. 2 In an experiment where the irradiance was 1000 uV, the reflectance could be increased by about 2.9 times.

[0090] When sunlight is used as the light source, even if the violet light enters the room through a glass window that transmits violet light, or even if the window is opened and sunlight enters the room directly, according to the results of measurements made by the inventor with the window open (measured with the line of sight facing out the open window), the light intensity of the violet light at a point one meter into the room from the window is 326 μW / cm ２ to 67 μW / cm ２ In order to make the violet light reach deeper into the room, it is necessary to use highly reflective wall and floor materials or to increase the diffusivity of the window glass. To achieve this, the window glass itself should be made to have a composition or structure that diffuses violet light, or a sheet with such functionality should be attached to the window glass, so that the violet light can be diffused deeper into the room and reach the eyes of people who are not sitting at a desk next to a window.

[0091] It should be noted that there are many diffusing materials on the market that have distinctive diffusion angle characteristics and transmittance characteristics, and therefore, a diffusing material can be selected from a variety of materials based on these characteristics.

[0092] (Directivity) Regarding light directionality, it is desirable to install a light source so that light reaches the direction of the face (line of sight), or to install a diffusing or reflective material. The height of the light source is also an important factor. For example, it is preferable to install the light source at a position based on the behavioral patterns in the office or home, and to set its height and direction. As a means for increasing directionality, it is preferable to install the light source so that the light emitted from the light source is directly directed toward the eyes, or to install the light source at a position within the field of view or in the line of sight so that the light emitted from the light source is easily directed toward the eyes. For example, when the fluctuation of the line of sight axis is relatively small (for example, during desk work as shown in Figures 6 and 8), it is preferable to install the light source at a position where it is irradiated at an angle of 30° or less with respect to the virtual line of sight axis of the person. This allows light to be irradiated to the eyes, thereby expressing the OPN5 gene or activating OPN5.

[0093] <Spectral Data> Next, important data (light spectral data, OPN5 absorption spectral data, etc.) that are taken into consideration when determining the light irradiation conditions and the installation position of the light source in the light irradiation device of the present invention will be described. The light irradiation device of the present invention is a device that can irradiate light to a human eye to express the OPN5 gene or activate OPN5 in the retina of the eye, and therefore is a device that sets the light irradiation conditions and the installation position of the light source by comparing data that are necessary when determining the light irradiation conditions and the installation position of the light source.

[0094] The measuring device for acquiring such data may be included in the light irradiation device according to the present invention, as shown in an example in Figure 13, or may be a measuring device separate from the light irradiation device. The measuring device 21 has a measuring unit 22 that measures received light spectrum data and a calculation unit 23 that calculates the light spectrum data and the absorption spectrum data of OPN5. The calculation unit 23 may be built in, or may not be built in but may be configured to transmit the data to an external calculation unit via communication means. The memory 24 stores the absorption spectrum data of OPN5, etc. The display unit 25 displays the calculation results.

[0095] In this example of the measuring device 21, the received light spectrum data is measured by the measuring unit 22, and the measured light spectrum data and the OPN5 absorption spectrum data are calculated by an internal or external calculation unit 23, thereby obtaining data for evaluating whether light can express the OPN5 gene or activate OPN5. This evaluation data can be used as basic data for evaluating the relationship between the received light and the OPN5 gene expression or OPN5 activation. In particular, by calculating and quantifying the degree of overlap between the measured light spectrum data and the OPN5 absorption spectrum data, this data can be used for objectively evaluating the physical effects of OPN5. This can be used, for example, to evaluate what wavelength range of light, at what irradiance, during what time period, and for how long irradiation is effective in relation to the physical effects of OPN5. Note that the light in the "received light spectrum data" refers not only to light from the light source of the light irradiation device of the present invention, but also to light spectrum data including all measured light. Furthermore, it is preferable that this measuring device 21 be capable of accurately measuring the light that enters the human eye, and it is particularly preferable that it be worn by the person or attached to a member that is worn on the person.

[0096] As shown in FIGS. 9 and 10, the calculation unit in this example of the measuring device 21 calculates the product of the optical spectrum data at each wavelength and the absorption spectrum data of the OPN5 as the effective spectral irradiance (W / m ２ / nm) and the effective spectral irradiance (W / m ２ / nm) can be used as evaluation data, and therefore the device can be used as an irradiation device to clarify the objective relationship between the obtained evaluation data and the physical effects achieved through OPN5.

[0097] In addition, the calculation unit calculates the spectral irradiance (W / m) of the absorption spectrum of sunlight specified by AM1.5G as shown in FIG. ２ / nm) and the absorption spectrum of OPN5 for each wavelength. ２ / nm) is the effective spectral irradiance (W / m ２ / nm) in the calculation unit. By doing so, the reference effective spectral irradiance (W / m ２ / nm) is the effective spectral irradiance (W / m ２ / nm) is calculated by the calculation unit, so that the degree (for example, percentage: %) of the actual received effective spectral irradiance relative to the common reference effective spectral irradiance can be generalized and evaluated. Based on the calculated results, an objective relationship with the physical effects of OPN5 can be clarified.

[0098] 12 compares the reference effective spectral irradiance (symbol b) shown in FIG. 11C with the received effective spectral irradiance (symbol a) shown in FIG. 9C. In this way, the received effective spectral irradiance obtained in FIG. 9, for example, is converted into the reference effective spectral irradiance (W / m) which is the product of the spectral irradiance of the sunlight spectrum specified by AM1.5G at each wavelength and the absorption spectrum of OPN5. ２ / nm). This allows for generalized evaluation of the degree (ratio: %) of the actual received effective spectral irradiance relative to a common reference effective spectral irradiance. In the results shown in FIG. 12, for example, the effective irradiance integrated over the wavelength range of 280 to 500 nm is 57 W / m for sunlight (symbol b). ２ and 3.3 W / m for violet light (symbol a). ２ If sunlight is standardized as 100%, violet light can be evaluated as 6%. In this way, by comparing the results with sunlight standardized as 100%, the objective relationship between the comparison results and the physical effects of OPN5 can be clarified. Furthermore, the obtained effective irradiance can be compared not only with the reference effective irradiance of sunlight, but also with the effective irradiance obtained with a different light source system, allowing comparisons between light sources.

[0099] "AM1.5G" is solar data adopted at the standard level for solar cell development, etc., and "AM" stands for Air Mass. This AM1.5G has been standardized by the American Society for Testing and Materials (ASTM), as can be seen in the URL "https: / / unit.aist.go.jp / rp-envene2022 / PV / ja / about_pv / output / measure.html," and the data is published at "https: / / tinystones.net / pv / pv04.html" (U.S. Department of Energy National Renewable Energy Laboratory (NREL)) ("https: / / www.nrel.gov / grid / solar-resource / spectra.html").

[0100] From FIG. 11(C), the maximum value of the effective spectral irradiance is 0.93 W / m ２ / nm (value at 402 nm). As mentioned above, the integrated value of the effective irradiance in the wavelength range of 280 to 500 nm is 57 W / m ２ The effective dose when exposed to AM 1.5G sunlight for 3 hours a day is 57 W / m ２ multiplied by 10,800 seconds, which is 615,600 J / m ２ (=615.6kJ / m ２ ) The maximum value is approximately 1 W / m ２ / nm, it is 10 times that, 10W / m ２ The effective irradiance is 10 W / m / nm, assuming that the effective spectral irradiance is a rectangular spectrum. ２ / nm×220nm=2200W / m ２ The effective dose is 21,600,000 J / m assuming irradiation for 3 hours a day at this effective irradiance. ２ (=21.6MJ / m ２ ) can be used.

[0101] As mentioned above, the effective irradiance integrated over the wavelength range of 280 to 500 nm is 57 W / m for sunlight. ２ and 3.3 W / m for violet light.２ For example, the minimum value of these values ​​is 0.01 W / m ２ / nm, and the effective irradiance is 0.1 W / m ２ , effective dose is 1000 J / m ２ In addition, the maximum effective spectral irradiance is 10 W / m ２ / nm, and the effective irradiance is 2200 W / m ２ , the effective dose is 21.6 MJ / m ２ (M is million) is an example. The effective irradiance is the value when the light is irradiated for three hours.

[0102] The optical spectrum data may be calculated by comparing it with all or part of the wavelength range of the absorption spectrum of OPN5. This allows calculation by comparing it with all or part of the wavelength range of the absorption spectrum of OPN5, even when the received light contains various optical spectrum data. Therefore, it is applicable to any evaluation in which the wavelength range of light is specified using a filter or the like. As a result, the device can be used as an irradiation device to clarify whether the physical effects of OPN5 are related to the effective spectral irradiance of light received over the entire wavelength range of the absorption spectrum of OPN5, or to the effective spectral irradiance of light received over a specific wavelength range of the absorption spectrum of OPN5. Furthermore, the wavelength range of light can be specified using a filter or the like, for example, to a specific wavelength range, such as violet light in the wavelength range of 360 to 400 nm, and therefore can also be used to verify detailed effects by specifying the wavelength range.

[0103] In the calculation unit of this example of the measuring device 21, when comparing wavelength regions, the effective spectral irradiance of received light is integrated in the wavelength region to be compared to obtain the effective irradiance of received light (W / m ２ ) is calculated, and the reference effective spectral irradiance is similarly integrated in the same wavelength range to obtain the reference effective irradiance (W / m ２ ) and compare the received light effective irradiance thus obtained with the reference effective irradiance (for example, as a percentage) for evaluation.

[0104] For comparison of the integrated results, the effective irradiance (W / m) obtained by integrating the results over a specific wavelength range was calculated. ２) can be compared, for example, between the reference effective irradiance of sunlight and the effective irradiance received by the violet light LED, and the result can be compared as the effective irradiance received by the violet light LED relative to the reference effective irradiance of sunlight. In the results shown in FIG. 12, for example, the effective irradiance integrated in the wavelength range of 280 to 500 nm is 57 W / m for sunlight. ２ and 3.3 W / m for violet light. ２ If sunlight is standardized as 100%, the violet light LED can be evaluated as 6%. In this way, by comparing it with sunlight standardized as 100%, the objective relationship between the comparison result and the physical effects of OPN5 can be clarified. Furthermore, the obtained effective irradiance can be compared not only with the reference effective irradiance of sunlight, but also with the effective irradiance obtained with a different light source system, allowing comparisons between light sources.

[0105] Furthermore, the calculation unit calculates the effective light irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the effective dose (J / m ２ ) and reference effective irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the reference effective dose (J / m ２ ) (for example, percentage: %), the dependency of light irradiation time on the effect on the body caused by the body absorbing light via OPN5 can be evaluated. The dose is the amount of light that is exposed in a day, and the exposure time can be short or strong light (for example, when a strong flash-like light is applied for a short time), or weak light can be applied for a long time. On the other hand, the time of exposure (time period) is not particularly limited, but in reality, exposure during the daytime is more effective.

[0106] These evaluations based on effective irradiance and effective dose make it possible to quantitatively evaluate the effects on the body caused by the body absorbing light via OPN 5. Clarifying this relationship can be used to evaluate, for example, what wavelength range of light, at what level of irradiance, at what time of day, and for how long irradiation is effective in relation to the physical effects of OPN 5.

[0107] 8(A) and 8(B) , and is preferably provided on eyeglasses, earphones, a wristwatch, a chest badge, or other items worn on the upper body, attached to the body itself by sticking, or attached to an object near or around the body. Such attachment is arbitrarily selected based on the installation form of the light source that irradiates light (light source form, light source installation position, etc.), so it is less intrusive in daily life and makes it easy to measure light spectrum data received by the eyes and body.

[0108] (Measurement of Spectral Data) Light spectral data can usually be measured using a spectrometer or a UV meter (also called a power meter). A spectrometer can measure and obtain spectral irradiance, and the result can be integrated with respect to wavelength to obtain irradiance. By integrating over a specific wavelength range, the irradiance in that wavelength range can be expressed, making it a preferred tool. On the other hand, a UV meter can directly display irradiance. For example, a commercially available UVA meter is convenient because it senses light from 320 to 400 nm and displays the irradiance in that wavelength range. However, from the perspective of quantitative measurement, a meter that is calibrated according to the sensor used is preferable. Therefore, since a UV meter cannot measure spectral information (wavelength dependency), it can be said that it is difficult to apply it to the various spectral quantities in the present invention. Note that the "dose" is simply calculated by multiplying the irradiance by the irradiation time (seconds).

[0109] <Setting Irradiation Conditions, etc. According to the Purpose> The light irradiation device according to the present invention irradiates a human eye with light to express the OPN5 gene or activate OPN5 in the retina of the eye, which can be useful for setting desirable irradiation conditions, etc. for a variety of diseases, including the improvement or prevention of depression, suppression or prevention of stress, improvement or increase in concentration, improvement or prevention of Alzheimer's disease, improvement or prevention of dementia and cognitive function, suppression of myopia progression (for example, suppression of axial length elongation), suppression of myopia onset, effects on choroidal thickness, cerebral blood flow and the nervous system, and others (testes, skin, etc.).

[0110] As for irradiation conditions, the light irradiation device of the present invention can be used to determine irradiation modes (irradiance, irradiation time, irradiation time interval, irradiance change cycle, irradiation period, etc.) that will produce a more effective improvement effect on diseases, etc. This is particularly advantageous for setting irradiance modes (irradiance, irradiation time, irradiation time interval, irradiance change cycle, irradiation period, etc.) for each target disease. Furthermore, the violet light effectively employed in the light irradiation device of the present invention can preferably be a constant light or a flashing light. Therefore, the light irradiation device of the present invention can be used to evaluate the irradiance modes (on intensity, off intensity, irradiation time period, peak irradiation time, irradiance change cycle, duty ratio, etc.) of such flashing light. Furthermore, the light irradiation device of the present invention can clarify an objective relationship with the effect of expressing the OPN5 gene in the retina or activating OPN5, which is desirable from the subject-centered perspective of providing an effective treatment to the test subject.

[0111] Furthermore, when evaluating the effect on such diseases, the degree (e.g., percentage) of the actual received effective spectral irradiance relative to a common reference effective spectral irradiance can be generalized and evaluated regardless of the measurement region or measurement time. As a result, it is possible to clarify the objective relationship with the effect of expressing the OPN5 gene in the retina or activating OPN5, and the device can be used to clarify such relationship.

[0112] [Method for operating light irradiation device] The method for operating a light irradiation device according to the present invention is a method for operating the above-mentioned light irradiation device (a light irradiation device that irradiates light onto a human eye to express the OPN5 gene or activate OPN5), and is characterized by comprising: a light source arrangement step of arranging a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5; a light data comparison step of comparing in advance or on the spot the spectral data of the light obtained by receiving the light irradiated from the light source arranged in the light source arrangement step with the absorption spectral data of OPN5; and a light setting step of setting the light irradiation conditions based on the results of the comparison in the light data comparison step to express the OPN5 gene or activate OPN5.

[0113] The operating method of this light irradiation device is similar to the components described for the light irradiation device described above. Note that in the operating method of this light irradiation device, the light irradiation conditions set in the light setting step are one or more conditions selected from the installation position of the light source, the light irradiation direction, the light wavelength range, the light wavelength form, the light irradiance, the light irradiation time zone, and the light irradiation duration, and the light is 360 to 400 nm light that overlaps with the absorption spectrum of OPN5, which are also similar to the components described for the light irradiation device.

[0114] In this operation method, particularly in the light setting step, the irradiation conditions of light irradiated from the light source are set based on the results of the comparison in the light data comparison step to express the OPN5 gene or activate OPN5, thereby allowing settings to be made according to the irradiation purpose, etc. Note that this light setting step does not have to be performed by the light irradiation device; in that case, the light setting step can be performed by a control device (such as a mobile communication terminal such as a smartphone equipped with a control computer, or a central control device) connected separately, wirelessly or via a cable, and settings according to the irradiation purpose, etc. Furthermore, the settings in this light setting step also include, for example, setting firmware at the manufacturing stage to provide the light irradiation conditions, if it is known in advance that the device will be used for a specific irradiation purpose.

[0115] [Light Irradiation System] Next, a light irradiation system will be described. The light irradiation system according to the present invention is characterized in that it includes a combination of two or more of the light irradiation devices according to the present invention described above, or includes two or more light sources constituting the light irradiation device according to the present invention described above.

[0116] In a light irradiation system that combines two or more light irradiation devices, each with its own irradiation conditions, a system can be configured in which each light irradiation device has its own role (irradiation purpose). As a result, for example, light irradiation devices with their own roles can be placed in positions corresponding to indoor activities and behavioral patterns. Furthermore, in a light irradiation system that includes two or more light sources constituting a light irradiation device, irradiation conditions corresponding to the role of each light source can be set so that each light source plays a role (irradiation purpose) to achieve a specific purpose, thereby configuring a system that achieves overall uniformity. As a result, for example, light set to achieve a specific purpose can be placed in positions corresponding to indoor activities and behavioral patterns.

[0117] (Optical Sensor) The light irradiation system determines the effective spectral irradiance of light actually received by the eye, and therefore, the substantial spectral irradiance of light received by the eye is measured by an optical sensor. Examples of optical sensors include GaAsP photodiodes, and any of these can be selected and applied. Such optical sensors 12 may be optical sensors 12 attached to eyeglasses, as shown in FIG. 8, or may be sensor 12 in the form of a chest band, or may be optical sensors attached around the eye, and are not particularly limited. The means for attaching the optical sensor to eyeglasses or around the eye are not particularly limited. The optical sensor may be directly attached to eyeglasses or hung on a hook or the like. Alternatively, the optical sensor may be attached to an ear hook or the like and hung on the ear.

[0118] (Light source installation mode and light control) In a light irradiation system, the installation mode of the light source (including the arrangement mode when a diffuser or reflector is provided as necessary) and the control of the light delivered to the eye are important. By using the light source installation mode and light control described below, the light delivered to the eye can be controlled to achieve expression of the OPN5 gene or activation of OPN5. Examples of light control include a means for controlling the light irradiation conditions and a means for controlling the light directionality.

[0119] As the "control means for light irradiation conditions", for example, it is preferable that the light emitted from one or more light sources is set by one or more means selected from setting or changing the wavelength range, setting or changing the irradiance, setting or changing the time period, and setting or changing the irradiation time.

[0120] Regarding "setting or changing the wavelength range," "setting a specific wavelength range" means setting the wavelength range of light irradiated from a light source, such as providing a light source that emits light in a specific wavelength range, or providing a filter that transmits wavelengths in a specific wavelength range in front of the light source to emit light in a specific wavelength range. Also, "changing a specific wavelength range" means changing the wavelength range of light irradiated from a light source, such as providing a separate light source that emits light in a different wavelength range and switching to a different filter that transmits wavelengths in a specific wavelength range in front of the light source to transmit light in a different wavelength range.

[0121] "Setting or changing the irradiance" refers to setting or changing the irradiance of light emitted from a light source to an arbitrary value. Such setting or changing of the irradiance is preferably set or changed depending on the level of effective spectral irradiance received by the eye. When the effective spectral irradiance received is sufficient from the perspective of the optical effect of OPN5 evaluated based on the evaluation method of the present invention, irradiation may be stopped or the irradiance may be reduced. On the other hand, when the effective spectral irradiance received is still insufficient from the perspective of the optical effect of OPN5 evaluated based on the evaluation method of the present invention, the irradiance may be increased. Specifically, for example, when a violet light LED light source emitting violet light with a wavelength of 360 to 400 nm is used, the lower and upper limits of the irradiance reaching the eye are not particularly limited. The lower limit of the irradiance is preferably 0.05 W / m ２ (5 μW / cm ２ ), more preferably 0.10 W / m ２ , and more preferably 0.2 W / m ２ The upper limit of the irradiance is preferably 50 W / m ２ (5000 μW / cm ２), more preferably 20 W / m ２ , more preferably 10 W / m ２ The range of the actual irradiance can be a range that combines the above-mentioned lower limit value and upper limit value, and it is preferable to arbitrarily set or change the irradiance within such a range.

[0122] "Setting or changing the time period" means arbitrarily setting or changing the time period during which light is emitted from the light source. The setting or change of the time period is preferably set or changed depending on the time period during which light should be emitted from the perspective of the light effect of OPN5 evaluated based on the evaluation method of the present invention. Specifically, for example, after the sun has set, light within the absorption spectrum range of OPN5 cannot be obtained from the sun outdoors. Therefore, from the perspective of not disrupting the circadian rhythm, it is desirable not to set or change the time period so that light is emitted indoors from the time period after the sun has set. Furthermore, since the time period can be set arbitrarily, it may be a regular or intermittent time period.

[0123] "Setting or changing the irradiation time" means arbitrarily setting or changing the irradiation time for emitting light from the light source. The setting or change of the irradiation time is preferably set or changed depending on the length of time for which light should be irradiated from the perspective of the light effect of OPN5 evaluated based on the evaluation method of the present invention. Specifically, for example, the light may be irradiated intermittently. When setting or changing the irradiation time, it is preferable to set the radiation intensity as well.

[0124] The "light directionality control means" is preferably set by one or more means selected from the following: installing or changing a light source (including installing or changing a light source when a diffuser or reflector is provided as needed) so that light emitted from one or more light sources is directed toward the eye; setting or changing the angle of light emitted from the light source; if a light diffusing material is provided, setting the diffusion angle of the light diffusing material and installing or changing a light source that utilizes the diffuser; if a light reflecting material is provided, setting the reflection angle of the reflector and installing or changing a light source that utilizes the reflector. This embodiment is a light directionality control means. "Directivity" is an important factor from the perspective of the optical effect of OPN5. For example, in the case of desk work, it is particularly desirable to have a light source positioned in the line of sight so that it irradiates light toward the eye. Furthermore, as shown in FIG. 7, it is preferable that the light direction can be automatically or manually changed from "D" to "D'".

[0125] In all of the "installation or change of a light source," "setting or change of the angle of light emitted from the light source," "installation or change of a diffusing material that diffuses light," and "installation or change of a reflective material that reflects light," it is preferable to install the material in advance so that the direction of light is directed toward the eye, or to install it so that it can be changed to any direction.

[0126] Such a light irradiation system is a system for effectively achieving the light effect of expressing the OPN5 gene or activating OPN5, and is desirable for evaluating, for example, the inhibition of myopia progression (e.g., inhibition of axial length elongation), the inhibition of myopia onset, choroidal thickness, effects on cerebral blood flow and the nervous system, and other effects (testes, skin, etc.).

[0127] 10 Light source 11 Reflector 12 Sensor D, D' Light direction 21 Light irradiation device 22 Measuring unit 23 Calculating unit 24 Memory 25 Display unit

Claims

1. A light irradiation device that irradiates the eye with light to express the OPN5 gene or activate OPN5, characterized in that it has a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5, and the irradiation conditions for the light irradiated from the light source are set to express the OPN5 gene or activate OPN5.

2. The light irradiation device according to claim 1, wherein the setting is performed by comparing the spectral data of the light received from the light source with the absorption spectral data of the OPN5 in advance or on the spot, and based on the results of the comparison.

3. The spectrum of the light received by irradiating the light from the light source is the spectral irradiance (W / m) of the light in the wavelength range of 280 to 500 nm. ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is the spectral irradiance (W / m ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ The light irradiation device according to claim 1 , wherein the light intensity is set to be 0.2% or more of the maximum value of the light intensity (nm).

4. The light irradiation device according to any one of claims 1 to 3, wherein the irradiation conditions are one or more selected from the irradiation direction of the light, the wavelength range of the light, the wavelength form of the light, the irradiance of the light, the irradiation time period of the light, and the irradiation time of the light.

5. The light irradiation device according to claim 1 or 2, wherein the light irradiation conditions are set by a light setting section provided together with the light source or provided separately.

6. A light irradiation device described in any one of claims 1 to 3, wherein the light irradiation conditions are set based on the results of the comparison and in accordance with a predetermined expression level of the OPN5 gene or activation level of OPN5.

7. The light irradiation device according to any one of claims 1 to 3, wherein the light is light of 360 to 400 nm that overlaps with the absorption spectrum of the OPN5.

8. A light irradiation device according to any one of claims 1 to 3, wherein the light source is positioned at a position selected from a position where the light is irradiated directly onto the eye, a position where the light enters the field of view, a position in the direction of the line of sight, a position where the light is irradiated onto the eye as diffused light diffused by a diffusing material, and a position where the light is irradiated onto the eye as reflected light reflected by a reflecting material.

9. A light irradiation device according to any one of claims 1 to 3, wherein (i) when the light source is located at a position where the light is irradiated directly toward the eye, the irradiance of the light is set depending on the distance and / or angle from the light source to the person; (ii) when the light source is located at a position within the field of view or in the line of sight, the irradiance of the light is set depending on the distance and / or angle from the light source to the person; (iii) when the light source is located at a position where the light is irradiated to the eye as diffused light diffused by the diffusing material, the irradiance of the light is set depending on the distance from the light source and the diffusing material to the person and / or the diffusion angle and transmittance of the diffusing material; and (iv) when the light source is located at a position where the light is irradiated to the eye as reflected light reflected by a reflective material, the irradiance of the light is set depending on the distance from the light source and the reflective material to the person and / or the reflectance of the reflective material.

10. The light irradiation device according to any one of claims 1 to 3, wherein the light source is selected from a structure-mounted light source attached to a floor (including underfoot), wall, ceiling (including suspended), or other structure; an installation-mounted light source attached to a desk, table, partition (room divider, screen), shelf, tabletop component, personal computer, display, PC keyboard, television, audio, or other device or installation; a built-in or mountable light source of a portable personal computer, tablet, smartphone, or other portable terminal; a body-mounted light source that is mountable on or detachable by attachment to a vision correction device, eye protection device, face protection device, neck hanging device, ear hook, head mounting device, or other body equipment; and a functional-device-mounted light source mounted on functional equipment for AR, VR, or MR (goggles, headset, or other functional equipment).

11. The light irradiation device according to any one of claims 1 to 3, wherein the orientation or position of the light source is set manually or automatically.

12. The spectrum of the received light is the spectral irradiance (W / m) of each wavelength in the wavelength range of 280 to 500 nm of the light. ２ / nm) and the relative absorbance of the absorption spectrum data of OPN5 for each wavelength. ２ / nm) is the spectral irradiance (W / m) of the absorption spectrum of sunlight specified by AM1.5G. ２ / nm) and the relative absorbance of the absorption spectrum of OPN5 for each wavelength. ２ The light irradiation device according to claim 1 or 2, wherein the light irradiation efficiency is evaluated in comparison with the light irradiation efficiency (λ / nm).

13. The light irradiation device according to claim 12, wherein the received light effective spectral irradiance is set to 0.2% or more of the reference effective spectral irradiance.

14. When comparing the effective spectral irradiance (W / m ２ / nm) is integrated over the wavelength range to be compared to obtain the effective irradiance (W / m ２ ) is obtained, and the reference effective spectral irradiance (W / m ２ / nm) is similarly integrated to obtain the reference effective irradiance (W / m ２ 13. The light irradiation device according to claim 12, wherein the received effective irradiance is calculated based on the reference effective irradiance.

15. The light irradiation device according to claim 14, wherein the received light effective irradiance is set to 0.2% or more of the reference effective irradiance.

16. The effective irradiance of the received light (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the effective dose (J / m ２ ) and the reference effective irradiance (W / m ２ ) multiplied by the irradiation time (seconds) to obtain the reference effective dose (J / m ２ 15. The light irradiation device according to claim 14, wherein:

17. The light irradiation device according to claim 16, wherein the effective dose of received light is set to 0.2% or more of the reference effective dose of received light.

18. A light irradiation device as described in claim 1 or 2, wherein the measurement during the comparison is performed by a measuring unit, and the measuring unit is provided in glasses, earphones, a wristwatch, a badge, or other item worn on the body, or is worn on the body itself, or is attached to an object near or around the body, depending on the form of the light source that emits the light.

19. A light irradiation device according to any one of claims 1 to 3, wherein the light is flashing light and / or constant light, and the irradiation conditions for each of the flashing light and / or constant light are set by comparing the spectral data of the irradiated light with the absorption spectral data of OPN5 in advance or on the spot, and based on the results of the comparison, the irradiation conditions for the flashing light and / or constant light are set.

20. A light irradiation system characterized by combining two or more light irradiation devices according to any one of claims 1 to 19, or comprising two or more light sources constituting a light irradiation device according to any one of claims 1 to 19.

21. A method for operating a light irradiation device that irradiates light onto an eye to express the OPN5 gene or activate OPN5, comprising: a light source arrangement step of arranging a light source that irradiates light with a wavelength in a wavelength range that overlaps with the absorption spectrum of OPN5; a light data comparison step of comparing in advance or on the spot the spectral data of the light obtained by receiving the light irradiated from the light source arranged in the light source arrangement step with the absorption spectral data of OPN5; and a light setting step of setting the light irradiation conditions based on the results of the comparison in the light data comparison step to express the OPN5 gene or activate OPN5.

22. A method for operating a light irradiation device according to claim 21, wherein the light irradiation conditions set in the light setting step are one or more conditions selected from the installation position of the light source, the direction of irradiation of the light, the wavelength range of the light, the wavelength form of the light, the irradiance of the light, the time period during which the light is irradiated, and the duration of irradiation of the light.

23. A method for operating a light irradiation device according to claim 21 or 22, wherein the light is light of 360 to 400 nm that overlaps with the absorption spectrum of the OPN5.