Heterocyclic regulator containing benzonitrogen, method of preparation thereof and use thereof.

Abstract

A heterocyclic regulator containing benzoic nitrogen, a method for its preparation, and its use. In particular, the present invention relates to a compound represented by the general formula (XIX), a method for its preparation, a pharmaceutical composition containing the compound, and a use of the compound as a regulator in the preparation of drugs for treating metabolic and related diseases, wherein each substituent of the general formula (XIX) is the same as defined in the description.

Description

A benzo-nitrogen-containing heterocyclic derivative regulator, its preparation method and application Technical Field

[0001] The present invention belongs to the field of medicine and biology, and specifically relates to a benzo-nitrogen-containing heterocyclic derivative regulator, a preparation method and an application thereof. Background Art

[0002] Diabetes mellitus is a common endocrine and metabolic disease caused by a variety of metabolic disorders, leading to multi-system and multi-organ damage. It has a high incidence rate, with approximately 425 million people suffering from diabetes worldwide. In China, the incidence rate is approximately 10%, of which type 2 diabetes accounts for 90%. The prevalence is still increasing, and the age of onset is becoming younger.

[0003] Currently, there are many types of drugs on the market for the treatment of type 2 diabetes, including insulin, biguanides, glucagon-like peptide 1 (GLP-1) receptor agonists, dipeptidyl peptidase (DPP-IV) inhibitors, sodium-glucose cotransporter 2 (SGLT-2) inhibitors, α-glucosidase inhibitors, etc., among which GLP-1 receptor agonists are the most popular.

[0004] GLP-1 is a peptide hormone secreted by human intestinal L cells. Its receptors are distributed in pancreatic islet cells, various gastrointestinal cells, and neurons in the central and peripheral nervous systems. Activation of the GLP-1 receptor has physiological effects such as promoting insulin secretion, inhibiting glucagon secretion, suppressing appetite, and delaying gastric emptying. Clinical evidence shows that compared with other hypoglycemic drugs, GLP-1 receptor agonists have a better blood sugar-lowering effect and are less likely to cause side effects such as hypoglycemia. In addition, they have additional cardiovascular benefits, can reduce food intake and delay gastric emptying, and are beneficial for weight control.

[0005] Currently available GLP-1 receptor agonists are all peptide drugs, most of which require subcutaneous administration, resulting in poor patient compliance. Furthermore, oral peptides have very low bioavailability. Therefore, there is a significant clinical need for the development of oral small molecule GLP-1 receptor agonists.

[0006] Currently, there are no approved small-molecule GLP-1 receptor agonists, and there is a huge clinical need. Oral small-molecule GLP-1 receptor agonists with lower costs and better compliance have the potential to treat a variety of metabolic diseases and have broad market prospects.

[0007] Summary of the Invention

[0008] The object of the present invention is to provide a compound represented by general formula (XIX), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0009] in,

[0010] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0011] L1, L2 or L3 are each independently selected from a bond, C 2-4 Alkenylene, C 2-4 Alkynylidene or -(CH2) n1 -;

[0012] Ring A is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0013] Ring B is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further deuterated, halogenated, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0014] Ring C is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further deuterated, halogenated, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0015] Ring D is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0016] Ring E is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0017] Alternatively, ring E is optionally substituted with one or more substituents selected from the group consisting of methyl, ethyl, methoxy, and ethoxy;

[0018] R 1 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0019] R c1 、R c3 or R c4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2)m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0020] R a1 、R a2 、R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0021] Or, R 9 or R 16 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0022] Or, when n is not 1,

[0023] R 1 and R 1 、R 2 and R 1 、R 4 and R 5 、R 5 and R 6 、R 7 and R 8 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1- 6-hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1- 6-halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0024] n, n1, m1, m2, m3 or m4 are each independently selected from 0, 1, 2, 3, 4 or 5.

[0025] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0026] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1- 3-deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0027] Preferably, R 13 Selected from -CD3, hydrogen, deuterium, fluorine, chlorine, bromine, methyl or cyclopropyl, wherein the methyl or cyclopropyl group is optionally further substituted by deuterium, halogen or C 1-3 The alkyl group is substituted by one or more substituents.

[0028] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0029] Ring A is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-12 Aryl or 5-12 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0030] Preferably, ring A is selected from C 6-12 Cycloalkyl, 6-12 membered heterocyclyl containing 1-3 N, O or S atoms, or 6-12 membered heteroaryl containing 1-3 N, O or S atoms;

[0031] More preferably, ring A is selected from

[0032] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0033] Ring B is selected from C 3-8Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; optionally further substituted by deuterium, halogen, amino, oxo, mercapto, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0034] Preferably, ring B is selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by deuterium, halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0035] More preferably, ring B is selected from Optionally further substituted with deuterium, halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents.

[0036] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0037] Ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S; optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, mercapto, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy or C 1-3 substituted by one or more substituents in a deuterated haloalkoxy group;

[0038] Preferably, ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 selected from N, O or S, or 5-8 membered heteroaryl containing 1-3 selected from N, O or S; optionally further substituted by deuterium, hydroxyl, thioxo, oxo or C 1-3 substituted by one or more substituents in a haloalkoxy group;

[0039] More preferably, ring C is selected from Optionally further substituted with one or more substituents selected from deuterium, hydroxy, thio or oxo.

[0040] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0041] Ring D is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl group containing 1-3 atoms selected from N, O or S;

[0042] Preferably, ring D is selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclyl containing 1-3 N, O or S atoms, or 5-8 membered heteroaryl containing 1-3 N, O or S atoms;

[0043] More preferably, ring D is selected from

[0044] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0045] Ring E is selected from C 3-8 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1- 3-Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0046] Preferably, ring E is selected from Optionally substituted with one or more substituents selected from the group consisting of methyl, ethyl, methoxy, and ethoxy.

[0047] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0048] R 1 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4, optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0049] Preferably, R 1 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , the amino group, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , optionally further substituted with deuterium, amino, halogen, deuterated methyl, hydroxy, methyl, cyclopropyl, oxo, thio, C 1-3 Alkyl or C 1-3 substituted by one or more substituents in the alkoxy group;

[0050] More preferably, R 1 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 14 、R 15 or R 16 are each independently selected from hydrogen, oxo, thioxo, cyano, methyl, fluoro, chloro, cyclopropyl, ethynyl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , the cyclopropyl, ethynyl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , optionally further deuterated, fluorinated, chlorinated, bromine, hydroxyl, -CD3, methyl, ethyl, cyclopropyl, oxo, thio or is substituted by one or more substituents.

[0051] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0052] R c1 、R c3 or R c4 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1or -(CH2) m4 C(O)OR a2 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0053] Preferably, R c1 、R c3 or R c4 Selected from fluorine, methyl, cyano, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl, oxetane, phenyl, -(CH2) m2 ORc2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino, methyl, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, cyclopropyl, oxetane, phenyl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with one or more substituents selected from deuterium, halogen, methoxy, deuterated methyl or hydroxy.

[0054] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0055] R a1 、R a2 、R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0056] Preferably, R a1 、R a2 、R b1 or R c2 Each is independently selected from fluorine, methyl, ethyl, -CH2F, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl, oxetane or phenyl, and the amino, methyl, ethyl, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, cyclopropyl, oxetane or phenyl is optionally further substituted with one or more substituents of deuterium, halogen, methoxy, deuterated methyl or hydroxy.

[0057] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0058] R 9 or R 16 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0059] Preferably, R 9 or R 16The atoms to which they are attached are linked to form a cyclopropyl group.

[0060] In a further preferred embodiment of the present invention, the compound of general formula (XIX):

[0061] R 1 and R 1 、R 2 and R 1 、R 4 and R 5 、R 5 and R 6 、R 7 and R 8 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0062] Preferably, R 1 and R 1 、R 2 and R 1 、R 4 and R 5 、R 5 and R 6 、R 7 and R 8 The atoms connected to them form cyclopropyl groups, Optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, nitro, hydroxy, cyano, oxo, thioxo, methyl or ethyl.

[0063] The object of the present invention is to provide a compound represented by general formula (XVIII), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0064] in,

[0065] R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 12 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0066] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0067] R a1 、R a2 、R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0068] Or, R 9 or R 16 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C6-12 Aryl or 5-12 membered heteroaryl;

[0069] or,

[0070] R 1 and R 10 、R 2 and R 12 、R 4 and R 5 、R 5 and R 6 、R 7 and R 8 、R 10 and R 12 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0071] R 13 , L1, L2, L3, Ring A, Ring B, Ring C, and Ring E are as described in the general formula (XIX);

[0072] n1, m1, m2, m3 or m4 are each independently selected from 0, 1, 2, 3, 4 or 5.

[0073] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0074] R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R7 、R 8 、R 9 、R 10 、R 12 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-3 Alkyl, C 1- 3-deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0075] Preferably, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 12 、R 14 、R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , the amino group, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, amino, halogen, deuterated methyl, hydroxy, methyl, cyclopropyl, oxo, thio, C 1-3 Alkyl or C 1-3 substituted by one or more substituents in the alkoxy group;

[0076] More preferably, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R9 、R 10 、R 12 、R 14 、R 15 or R 16 are each independently selected from hydrogen, oxo, thioxo, cyano, methyl, fluoro, chloro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , the cyclopropyl, ethynyl or -(CH2) m1 OR c1 , optionally further deuterated, fluorinated, chlorinated, bromine, hydroxyl, -CD3, methyl, ethyl, cyclopropyl, oxo, thio or is substituted by one or more substituents.

[0077] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0078] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or - (CH2) m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0079] Preferably, R c1 Selected from fluorine, methyl, cyano, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl, oxetane, phenyl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino, methyl, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, cyclopropyl, oxetane, phenyl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 Rb1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with one or more substituents selected from deuterium, halogen, methoxy, deuterated methyl or hydroxy.

[0080] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0081] R a1 、R a2 、R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0082] Preferably, R a1 、R a2 、R b1 or R c2 Each is independently selected from fluorine, methyl, ethyl, -CH2F, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl, oxetane or phenyl, and the methyl, ethyl, -CH2F, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl, oxetane or phenyl is optionally further substituted with one or more substituents of deuterium, halogen, methoxy, deuterated methyl or hydroxy.

[0083] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0084] R 9 or R 16 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0085] Preferably, R 9 or R 16 The atoms to which they are attached are linked to form a cyclopropyl group.

[0086] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0087] R 1 and R 10 、R 2 and R 12 、R 4 and R 5 、R 5 and R 6 、R7 and R 8 、R 10 and R 12 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1- 3-deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0088] Preferably, R 1 and R 10 、R 2 and R 12 、R 4 and R 5 、R 5 and R 6 、R 7 and R 8 、R 10 and R 12 The atoms connected to them form cyclopropyl groups, Optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, nitro, hydroxy, cyano, oxo, thioxo, methyl or ethyl.

[0089] In a further preferred embodiment of the present invention, the compound of formula (XVIII):

[0090] R 1 and R 10 、R 2 and R 12 、R 4 and R 5 、R 5 and R6 、R 7 and R 8 、R 10 and R 12 The atoms connected to them form cyclopropyl groups, Optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, nitro, hydroxy, cyano, oxo, thioxo, methyl or ethyl.

[0091] In a further preferred embodiment of the present invention, the compound of general formula (XVIII) is further represented by general formula (XVIII-A):

[0092] Among them, ring A, ring B, ring C, ring E, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 、R 15 、R 16 , L1, L2 and L3 are as defined in the general formula (XVIII).

[0093] In a further preferred embodiment of the present invention, the compound of general formula (XVIII) is further represented by general formula (XVIII-B):

[0094] Among them, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 、R 15 and L1 are as defined in the general formula (XVIII).

[0095] In a further preferred embodiment of the present invention, the compound of general formula (XVIII) is further represented by general formula (XVIII-1):

[0096] In a further preferred embodiment of the present invention, the compound of general formula (XVIII) is further represented by general formula (XVIII-A-1):

[0097] In a further preferred embodiment of the present invention, the compound of general formula (XVIII) is further represented by general formula (XVIII-B-1):

[0098] The object of the present invention is to provide a compound represented by general formula (V), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0099] in,

[0100] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0101] Or, R 5 and R 6 Linking with adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6-sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0102] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、 -NR a5 S(O)NR a4 R b4 、-(CH2) n2 R a5 R b5 or The amino group, C1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0103] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 or R b6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0104] Or, R a1 and R b1 、R a2 and R b2 、R a3 and Rb3 、R a4 and R b4 、R a5 and R b5 、R a6 and R b6 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0105] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0106] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0107] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) n2 R a5 R b5 or Optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0108] n1-n3 are integers from 0 to 5;

[0109] m1 is an integer from 0 to 5;

[0110] When R 7 、R 8 is hydrogen, R 9 、R 10 、R 12 is methyl, R 3 、R 5 When it is fluorine, R 4 and R 6 Not all methyl groups at the same time;

[0111] When R 7 and R 8 is hydrogen, R 9 、R 10 、R 12 is methyl, R 3 is hydrogen, R 5 When it is a halogen, R 4 and R 6 Not all methyl groups at the same time;

[0112] When R 7 、R 8 、R 9 、R 10 、R 12 is methyl, R 5 When it is fluorine, R 4 When R is halogen, trifluoromethyl or cyclopropyl, 6 Not simultaneously hydrogen;

[0113] When R7 、R 8 、R 9 、R 10 is methyl, R 12 is a deuterated methyl group, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is a deuterated methyl group, R 6 Not simultaneously deuterated methyl;

[0114] When R 4 、R 6 、R 7 、R 8 、R 9 、R 10 is methyl, R 3 、R 5 When is fluorine, R 12 Not simultaneously deuterated methyl;

[0115] When R 7 、R 8 、R 9 、R 10 、R 12 is methyl, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is methyl, R 6 Not all methyl groups at the same time;

[0116] When R 7 、R 8 、R 9 、R 10 is methyl, R 12 is a deuterated methyl group, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is a deuterated methyl group, R 6 Not simultaneously deuterated methyl;

[0117] When R 4 、R 6 、R 7 、R 8 、R 9 、R 10 is methyl, R 3 、R 5 When is fluorine, R 12 Different from deuterated methyl.

[0118] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0119] R 4 、R 5 or R6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 1-3 Alkyl, C 1-3 Sulfanyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms; optionally further substituted by halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 substituted by one or more substituents in the alkoxy group;

[0120] Preferably, R 4 、R 5 or R 6 Each is independently selected from fluorine, methyl, cyano, ethynyl, methylthio, amino, cyclopropyl, oxetane; and optionally further substituted by halogen, methoxy, or deuterated methyl.

[0121] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0122] R 5 and R 6 Linking with adjacent atoms to form C 3-6 Cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, C 1-3 Alkyl, oxo or one or more substituents;

[0123] Preferably, R 5 and R 6 Linked with adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 selected from N, O or S; optionally further substituted by halogen, amino, C 1-3 Alkyl, oxo or one or more substituents;

[0124] More preferably, R 5 and R 6 Linking with adjacent atoms to form Optionally further substituted with halogen, amino, C 1-3 The alkyl group or the oxo group may be substituted by one or more substituents.

[0125] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0126] R 7 、R 8 Each independently selected from deuterium or C 1-6 deuterated alkyl;

[0127] Preferably, R 7 、R8 Each independently selected from deuterium or C 1-3 Deuterated alkyl.

[0128] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0129] R 9 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0130] Preferably, R 9 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-8 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0131] More preferably, R 9 Selected from cyano, cyclopropyl; optionally further halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl.

[0132] In another embodiment of the present invention, the compound of formula (V):

[0133] R 9 The carbon atoms connected to it form a C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0134] Preferably, R 9 The carbon atoms connected to it form a C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0135] More preferably, R 9 The carbon atom to which it is attached is further preferably linked to form a cyclopropyl group.

[0136] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0137] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n2 R a5 R b5 or The amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0138] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 Rb4 、-(CH2) n2 R a5 R b5 or The amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1- 3. The alkyl group is substituted by one or more substituents.

[0139] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0140] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0141] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0142] More preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1-3 The alkyl group is substituted by one or more substituents.

[0143] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0144] R 12 Selected from C 1-3 Alkyl, C 3-6 Cycloalkyl, -(CH2) n2 R a5 R b5 or Optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1- 3 alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0145] Preferably, R 12 Selected from methyl, cyclopropyl, -(CH2) n2 R a5 R b5or Optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1- 3 alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 The aryl group or the 5-8 membered heteroaryl group is substituted by one or more substituents.

[0146] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0147] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0148] Preferably, R 12 Selected from C 1-3 alkyl;

[0149] More preferably, R 12 Selected from methyl.

[0150] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0151] Ra1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 or R b6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0152] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 or R b6 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0153] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0154] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 、R a5 and R b5 、R a6 and R b6 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0155] Preferably, R a2 and R b2 、Ra3 and R b3 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0156] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0157] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0158] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0159] More preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0160] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0161] R a1 and R b1 、Ra2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0162] Preferably, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0163] More preferably, R a2 and R b2 、R a3 and R b3 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0164] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0165] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0166] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1- 3 haloalkyl;

[0167] More preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from methyl.

[0168] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0169] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0170] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, cyano, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0171] More preferably, R 7 、R 8 、R 9 or R 10 Each is independently selected from methyl, fluoro, cyclopropyl or ethynyl.

[0172] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0173] R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0174] Preferably, R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl;

[0175] More preferably, R 7 、R 8 、R9 or R 10 The atoms to which they are attached are linked to form a cyclopropyl group.

[0176] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0177] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2- 4-alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 The aryl group or the 5-8 membered heteroaryl group is substituted by one or more substituents.

[0178] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0179] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0180] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0181] More preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, cyano, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 ;

[0182] More preferably, R 7 、R 8 、R 9 or R 10 Each is independently selected from methyl, fluoro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 .

[0183] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0184] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0185] Preferably, R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2- 4-Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0186] More preferably, R c1 is selected from fluoro, methyl, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane; optionally further substituted by halogen, methoxy or deuterated methyl.

[0187] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0188] R 10 The atoms connected to it and the adjacent atoms link to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0189] Preferably, R 10 The atoms connected to it and the adjacent atoms link to form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0190] More preferably, R 10 The atoms connected to it and the adjacent atoms form a link

[0191] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0192] R 10 The atoms connected to it and the adjacent atoms form a link

[0193] In a further preferred embodiment of the present invention, the compound of general formula (V):

[0194] R 10 The atoms connected to it and the adjacent atoms form a link

[0195] In a further preferred embodiment of the present invention, the compound of general formula (V) is further represented by general formula (V-1):

[0196] The object of the present invention is to provide a compound represented by general formula (XVI), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0197] in,

[0198] Ring F is selected from C 3-18 Cycloalkyl, 3-18 membered heterocyclic group, C 6-18 Aryl or 5-18 membered heteroaryl;

[0199] Ring B is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0200] Ring C is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0201] Ring E is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-10 membered heteroaryl;

[0202] Alternatively, ring E is Optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl;

[0203] L1, L2 or L3 are each independently selected from a bond, a sub-C 2-4 Alkenyl, C 2-4 Alkynyl, -(CH2) n1 -or-(CH2) n5 NR b5 , the sub-C 2-4 Alkenyl, C 2-4 Alkynyl, -(CH2) n1 -or-(CH2) n5 NR b5, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1- 6-hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1- 6-halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0204] R 1 Each independently selected from Hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 Rb8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further Halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0205] or,

[0206] R 1 Linked to the connected atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further Deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 Rb1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0207] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1- 6-deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0208] or,

[0209] R a1 and R b1 、R a2 and R b2 、R a3 and Rb3 、R a4 and R b4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and R b10 Linked to adjacent atoms to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0210] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0211] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0212] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0213] Or, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0214] or,

[0215] R 10 and R 12 The atoms connected to it form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0216] n1-n5, m1 or x are each independently selected from 0, 1, 2, 3, 4 or 5.

[0217] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0218] Ring F is selected from C 3-12 Cycloalkyl, 3-14 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-14 Aryl or a 5-14 membered heteroaryl group containing 1-3 heteroatoms selected from N, O or S;

[0219] Preferably, ring F is selected from C 3-10 Cycloalkyl, 5-14 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6- 10 Aryl or a 5-10 membered heteroaryl group containing 1-3 heteroatoms selected from N, O or S;

[0220] More preferably, ring F is selected from C3-6 Bridged cycloalkyl, 8-14 membered tricyclic fused heterocyclic group containing 1-5 heteroatoms, 3-8 membered bridged heterocyclic group containing 1-3 heteroatoms, fused heterocyclic group containing 1-3 heteroatoms, bridged heterocyclic group containing 1-3 heteroatoms, C 6-10 Aryl or a 5-10 membered fused heteroaryl group containing 1-3 heteroatoms;

[0221] More preferably, ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0222] Note: Indicates connection with L1.

[0223] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0224] Ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0225] Note: Indicates connection with L1.

[0226] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0227] Ring B is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy or C 1-3 substituted by one or more substituents in a deuterated haloalkoxy group;

[0228] Preferably, ring B is selected from C 3-6Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0229] More preferably, ring B is selected from Optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents.

[0230] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0231] Ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 selected from N, O or S; optionally further substituted by halogen, amino, nitro, hydroxyl, cyano, oxo, mercapto, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy or C 1-3 substituted by one or more substituents in a deuterated haloalkoxy group;

[0232] Preferably, ring C is selected from C 3-8 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 selected from N, O or S or 5-6 membered heteroaryl containing 1-3 selected from N, O or S; optionally further substituted by hydroxyl, thioxo, oxo or C 1-6 substituted by one or more substituents in a haloalkoxy group;

[0233] More preferably, ring C is selected from Optionally further substituted with one or more substituents selected from the group consisting of hydroxy, thio or oxo.

[0234] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0235] Ring E is selected from C 3-10Cycloalkyl, 3-12 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-12 Aryl or 5-12 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0236] Preferably, ring E is selected from C 3-6 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl;

[0237] More preferably, ring E is selected from Optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl.

[0238] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0239] Ring E is Optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl.

[0240] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0241] R 1 Each independently selected from Hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n1 S(O)2R b5 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n1 S(O)2R b5 , optionally further Halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0242] Preferably, R 1 Each independently selected from Hydrogen, deuterium, amino, oxo, fluorine, chlorine, bromine, C 1-3Alkyl, C 1- 3-deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3-8 Bridged cycloalkyl, C 3-8 Spiroalkyl, 3-8 membered spiro heterocyclic group containing 1-3 heteroatoms, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3- 8-bridged cycloalkyl, C 3-8 Spiroalkyl, 3-8 membered spiro heterocyclic group containing 1-3 heteroatoms, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 Rb4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further Halogen, cyano or C 1-3 The alkyl group is substituted by one or more substituents.

[0243] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0244] More preferably, R 1 Each independently selected from Hydrogen, deuterium, amino, oxo, cyano, fluorine, chlorine, bromine, methyl, ethyl, cyclopropyl, -CD3, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino, methyl, ethyl, cyclopropyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further Halogen, cyano or C 1-3 The alkyl group is substituted by one or more substituents.

[0245] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0246] R 1 Linked to the connected atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 selected from N, O or S, C 6-10Aryl or 5-8 membered heteroaryl containing 1-3 selected from N, O or S, optionally further Deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0247] Preferably, R 1 Linked to the connected atoms to form C 3-4 Cycloalkyl or 5-7 membered heterocyclic group containing 1-3 selected from N, O or S, optionally further Deuterium, halogen, C 1-3Alkyl, C 1-3 Deuterated alkyl, C 3-6 Cycloalkyl, amino, oxo, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0248] More preferably, R 1 are linked to the atoms to form cyclopropyl groups, optionally further Deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 Cycloalkyl, amino, oxo, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2)n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents.

[0249] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0250] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 3-6 Bridged cycloalkyl, C 3-6 Spiroalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 3-6 Bridged cycloalkyl, C 3- 6-spirocycloalkyl, 3-8-membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen or C 1-3 The alkyl group is substituted by one or more substituents;

[0251] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, methyl, ethyl, cyano, deuterated methyl, cyclopropyl, cyclopentyl, phenyl, The methyl, ethyl, deuterated methyl, cyclopropyl, cyclopentyl, phenyl, Optionally further substituted with one or more fluorines.

[0252] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0253] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and Rb10 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0254] Preferably, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and R b10 Linked to adjacent atoms to form C 3-6 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents.

[0255] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0256] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1- 3 haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1- 3-deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0257] Preferably, R 4 、R 5 or R 6Each is independently selected from fluoro, cyano, cyclopropyl or methyl, and the cyclopropyl or methyl is optionally further substituted with one or more substituents selected from deuterium, deuterated methyl, methyl, cyclopropyl or oxo.

[0258] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0259] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1- 3-deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0260] Preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, cyano, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , the C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , optionally further substituted with one or more substituents selected from deuterium, deuterated methyl, methyl, cyclopropyl or oxo;

[0261] More preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 are each independently selected from cyano, methyl, fluoro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , the methyl, cyclopropyl, ethynyl or -(CH2) m1 OR c1, optionally further substituted with one or more substituents selected from deuterium, deuterated methyl, methyl, cyclopropyl or oxo.

[0262] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0263] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 Each is independently selected from cyano, methyl, fluoro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , the methyl, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , optionally further substituted with one or more substituents selected from deuterium, hydroxy, deuterated methyl, methyl, cyclopropyl or oxo.

[0264] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0265] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0266] Preferably, R c1 is selected from fluorine, methyl, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane, wherein the methyl, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane is optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl.

[0267] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0268] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 The atoms connected to them form C 3-6 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms;

[0269] Preferably, R 7 、R8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms;

[0270] More preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 or R 15 The atoms to which they are connected form cyclopropyl or

[0271] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0272] R 10 and R 12 The atoms connected to it form a C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms;

[0273] Preferably, R 10 and R 12 The atoms connected to it form a C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms;

[0274] More preferably, R 10 and R 12 The atoms connected to it form a link

[0275] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0276] R 10 The atoms connected to it and the adjacent atoms form a link

[0277] In a further preferred embodiment of the present invention, the compound of formula (XVI):

[0278] Ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0279] Note: Indicates connection with L1.

[0280] In a further preferred embodiment of the present invention, the compound of general formula (XVI) is further represented by general formula (XVI-1):

[0281] In a further preferred embodiment of the present invention, the compound of general formula (XVI) is further represented by general formula (XVI-A):

[0282] in,

[0283] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further Hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 Rb4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0284] or,

[0285] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 Ra5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2)n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0286] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1- 6-deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0287] or,

[0288] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and R b10 Linked to adjacent atoms to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0289] Ring B, Ring C, Ring E, L1, L2, L3, R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 12 、R 13 、R 14 、R 15 , n1, n2, n3, n4, n5, m1, and x are defined as described in the general formula (XVI).

[0290] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0291] R 1and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 selected from N, O or S, optionally further Deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0292] Preferably, R 1 and R 2 、R 1 and R 11 Respectively linked with adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 selected from N, O or S, optionally further Deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 Cycloalkyl, amino, oxo, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 is substituted by one or more substituents;

[0293] More preferably, R 1 and R 2 、R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NRa5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 、-(CH2) n5 C(O)NR a10 R b10 、 Deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, amino or oxo.

[0294] Note: Indicates connection with L1.

[0295] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0296] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1- 3 alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3- 6-membered cycloalkyl, 3-6-membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 Rb1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1- 3-deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0297] Preferably, R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, amino, oxo, fluorine, chlorine, bromine, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3-8 Bridged cycloalkyl, C 3-8Spiroalkyl, 3-8 membered spiro heterocyclic group containing 1-3 heteroatoms, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3- 8-bridged cycloalkyl, C 3-8 Spiroalkyl, 3-8 membered spiro heterocyclic group containing 1-3 heteroatoms, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、- (CH2) n1 C(O)NRa6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further substituted by halogen, cyano or C 1-3 The alkyl group is substituted by one or more substituents.

[0298] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0299] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 3-6 Bridged cycloalkyl, C 3-6 Spiroalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 3-6 Bridged cycloalkyl, C 3- 6-spirocycloalkyl, 3-8-membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen or C 1-3 The alkyl group is substituted by one or more substituents;

[0300] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, methyl, ethyl, cyano, deuterated methyl, cyclopropyl, cyclopentyl, phenyl, The methyl, ethyl, deuterated methyl, cyclopropyl, cyclopentyl, phenyl, Optionally further substituted with one or more fluorines.

[0301] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0302] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and Rb4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and R b10 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0303] Preferably, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 、R a6 and R b6 、R a8 and R b8 、R a9 and R b9 、R a10 and R b10 Linked to adjacent atoms to form C 3-6 Cycloalkyl or a 3-6 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S.

[0304] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0305] In the general formula (XVI-A) Further As shown, optionally further substituted by halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl;

[0306] Ring M1, Ring M2, Ring M3, Ring M4, Ring M5, Ring M6, Ring M7, Ring M8, M9 or M 10 Each independently selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1- 6-hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1- 6-halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0307] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0308] In the general formula (XVI-A) Further As shown, optionally further substituted by halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl;

[0309] Ring M1, Ring M2, Ring M3, Ring M4, Ring M5, Ring M6, Ring M7, Ring M8, M9 or M 10 Each independently selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0310] Preferably, ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7, ring M8, M9 or M 10 Each independently selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted with halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 The cycloalkyl group or the deuterated methyl group is substituted with one or more substituents.

[0311] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0312] In the general formula (XVI-A) Further As shown, optionally further substituted by halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl;

[0313] Ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7 or ring M8 are each independently selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6-deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0314] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0315] In the general formula (XVI-A) Further As shown, optionally further substituted by halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl;

[0316] Ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7 or ring M8 are each independently selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0317] Preferably, ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7 or ring M8 are each independently selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted with halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 The cycloalkyl group or the deuterated methyl group is substituted with one or more substituents.

[0318] In a further preferred embodiment of the present invention, the compound of formula (XVI-A):

[0319] R 1 and R 2 、R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 、-(CH2) n5 C(O)NR a10 R b10 、 Deuterium, halogen, C 1-3Alkyl, C 1-3 Deuterated alkyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, amino or oxo.

[0320] Note: Indicates connection with L1.

[0321] In a further preferred embodiment of the present invention, the compound of formula (XVI-A) is further represented by formula (XVI-B):

[0322] The object of the present invention is to provide a compound represented by general formula (II), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0323] in,

[0324] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0325] Or, R 1 、R 2 、R 3 or R 11 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0326] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0327] Or, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0328] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0329] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0330] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0331] Or, R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6- 12 Aryl or 5-12 membered heteroaryl;

[0332] n1 is an integer from 0 to 5;

[0333] m1 is an integer ranging from 0 to 5.

[0334] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0335] R1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0336] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0337] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, C 1-3 substituted by one or more substituents of alkyl, amino or oxo;

[0338] Preferably, R 1 and R 2 、R 1 and R 11 They are linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, which is optionally further substituted by an oxo group.

[0339] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0340] R 1 and R 2 、R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further halogen, C1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, amino or oxo.

[0341] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0342] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted with one or more substituents selected from halogen, amino and oxo;

[0343] Preferably, R 1 and R 2 、R 1 and R 11 They are linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, which is optionally further substituted by an oxo group.

[0344] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0345] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0346] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0347] More preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1-3 The alkyl group is substituted by one or more substituents.

[0348] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0349] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0350] Preferably, R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 Rb3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1-3 The alkyl group is substituted by one or more substituents.

[0351] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0352] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0353] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0354] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0355] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aryl or 5-8 membered heteroaryl.

[0356] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0357] R a2 and Rb2 、R a3 and R b3 Linked to adjacent atoms to form C 3-8 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0358] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0359] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0360] Preferably, R 4 、R 5 or R 6 are each independently selected from fluoro or methyl.

[0361] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0362] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0363] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from methyl.

[0364] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0365] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, C 1-3 Alkyl, C 3-6 substituted by one or more substituents of cycloalkyl, amino or oxo;

[0366] Preferably, R 1 and R2 、R 1 and R 11 are linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, optionally further C 3-6 substituted by cycloalkyl or oxo;

[0367] More preferably, R 1 and R 2 、R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, amino or oxo.

[0368] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0369] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0370] Preferably, R 4 、R 5 or R 6 Each is independently selected from fluoro, cyano, cyclopropyl or methyl.

[0371] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0372] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0373] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from methyl or cyclopropyl.

[0374] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0375] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0376] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0377] R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0378] Preferably, R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl;

[0379] More preferably, R7 、R 8 、R 9 or R 10 The atoms to which they are attached are linked to form a cyclopropyl group.

[0380] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0381] R 10 The atoms connected to it and the adjacent atoms link to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0382] Preferably, R 10 The atoms connected to it and the adjacent atoms link to form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0383] More preferably, R 10 The atoms connected to it and the adjacent atoms form a link

[0384] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0385] R 10 The atoms connected to it and the adjacent atoms form a link

[0386] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0387] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0388] Preferably, R c1 is selected from fluoro, methyl, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane; optionally further substituted by halogen, methoxy or deuterated methyl.

[0389] In a further preferred embodiment of the present invention, the compound of general formula (II):

[0390] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1- 6-hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0391] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0392] More preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, cyano, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 ;

[0393] More preferably, R 7 、R 8 、R 9 or R 10 Each is independently selected from methyl, fluoro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 .

[0394] In a further preferred embodiment of the present invention, the compound of general formula (II) is further represented by general formula (II-1):

[0395] The object of the present invention is to provide a compound represented by general formula (XI), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0396] in,

[0397] Ring E is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0398] L2 is selected from a bond, -(CH2) n4 -, Sub-C 2-4 Alkenyl, C 2-4 Alkynyl;

[0399] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents in aryl or 5-10 membered heteroaryl; R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0400] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0401] Or, R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6- 12 Aryl or 5-12 membered heteroaryl;

[0402] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 or R b9 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0403] Or, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a7 and R b7 or R a8 and R b8 or R a9 and R b9 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0404] R 4 、R5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1- 6-deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0405] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0406] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 or R b9 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0407] Or, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a7 and R b7 or R a8 and R b8 or R a9 and Rb9 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0408] n1~n4 are integers of 0~5.

[0409] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0410] Ring E is selected from C 3-8 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms;

[0411] Preferably, ring E is selected from

[0412] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0413] Ring E is selected from

[0414] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0415] Ring E is selected from

[0416] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0417] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 The amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 In a further preferred embodiment of the present invention, the compound of formula (XI) is:

[0418] Preferably, R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3- 6-membered cycloalkyl, 3-6-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1- 3 alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0419] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0420] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 The amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0421] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0422] R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5、-(CH2) n1 O(CH2) n2 R b5 、 In a further preferred embodiment of the present invention, the compound of formula (XI):

[0423] Preferably, R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 is substituted by one or more substituents;

[0424] More preferably, R 1 and R 2 or R 1 and R 11 Respectively linked to adjacent atoms to form a phenyl group, a 5-7 membered heterocyclic group containing 1-3 selected from N, O or S, optionally further substituted by an oxo group, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 replaced.

[0425] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0426] R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1- 3-deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、 -P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n P(O)R a7 R b7 or -(CR a8 R b8 )n4 C(O)NR a9 R b9 is substituted by one or more substituents;

[0427] Preferably, R 1 and R 2 or R 1 and R 11 They are linked to adjacent atoms to form phenyl or a 5-7 membered heterocyclic group containing 1-3 groups selected from N, O or S, optionally further substituted by methyl, halogen, oxo, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 is substituted by one or more substituents;

[0428] More preferably, R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms Optionally further substituted with methyl, halogen, oxo, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1O(CH2) n2 R b5 、 -(CH2) n P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 is substituted by one or more substituents.

[0429] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0430] R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms

[0431] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0432] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 Cycloalkyl, C 1-3 alkyl halide;

[0433] Preferably, R 4 、R 5 or R 6 Each is independently selected from fluoro, methyl, and cyclopropyl.

[0434] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0435] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 alkyl halide;

[0436] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen or methyl.

[0437] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0438] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 or R b6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl; or, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 The aryl group or the 5-10 membered heteroaryl group is substituted by one or more substituents.

[0439] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0440] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 or R b9 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0441] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 or R b9 are each independently selected from hydrogen, deuterium, halogen, cyano, cyclopropyl, cyclopentyl, methyl, ethyl, phenyl or

[0442] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0443] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、Ra6 or R b6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 alkyl halide;

[0444] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 or R b6 Each is independently selected from hydrogen, deuterium, halogen, and methyl.

[0445] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0446] Ring E is

[0447] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0448] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3- 6 cycloalkyl or C 1-3 alkyl halide;

[0449] Preferably, R 4 、R 5 or R 6 Each is independently selected from fluoro, methyl, cyano or cyclopropyl.

[0450] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0451] R 7 、R 8 、R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0452] Preferably, R 7 、R 8 、R9 or R 10 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl;

[0453] More preferably, R 7 、R 8 、R 9 or R 10 The atoms to which they are attached are linked to form a cyclopropyl group.

[0454] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0455] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 or R b9 are each independently selected from hydrogen, deuterium, halogen, cyano, cyclopropyl, cyclopentyl, methyl, ethyl, deuterated methyl, phenyl or

[0456] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0457] R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a7 and R b7 or R a8 and R b8 or R a9 and R b9 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0458] Preferably, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a7 and R b7 or R a8 and R b8 or R a9 and R b9 They are linked to adjacent atoms to form cyclopropyl groups.

[0459] In a further preferred embodiment of the present invention, the compound of formula (XI):

[0460] R 1 and R 2 or R 1 and R 11 They are linked to adjacent atoms to form phenyl or a 5-7 membered heterocyclic group containing 1-3 groups selected from N, O or S, optionally further substituted by methyl, halogen, oxo, cyclopropyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2)n1 P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 is substituted by one or more substituents;

[0461] Preferably, R 1 and R 2 or R 1 and R 11 Linked to adjacent atoms Optionally further substituted with methyl, halogen, oxo, cyclopropyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 R b5 、 -(CH2) n1 P(O)R a7 R b7 or -(CR a8 R b8 ) n4 C(O)NR a9 R b9 is substituted by one or more substituents.

[0462] In a further preferred embodiment of the present invention, the compound of general formula (XI) is further represented by general formula (XI-1):

[0463] The object of the present invention is to provide a compound represented by general formula (XV), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0464] in,

[0465] R 1 、R 2 、R 3 or R 11are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1- 6 alkyl, C 1-6Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0466] or,

[0467] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0468] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0469] Or, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a6 and R b6 or R a8 and R b8 or R a9 and R b9 or R a10 and R b10 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0470] Ring A is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy or C 1-6 substituted by one or more substituents in a haloalkoxy group;

[0471] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0472] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R 14 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0473] Or, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R 14The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0474] n1-n5 are integers from 0 to 5;

[0475] x is an integer from 0 to 5.

[0476] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0477] R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-3Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1- 3 alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0478] Preferably, R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclyl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n5 C(O)NR a10 R b10 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or C 2-4 Alkynyl, optionally further substituted with halogen, -NS(O)R a1 R b1 、C 1-3 Alkyl or C 3-6 substituted by one or more substituents in the cycloalkyl group;

[0479] More preferably, R 1 、R 2 、R 3 or R 11 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 2-4 Alkynyl, C 3-8 Bridged cycloalkyl, C 3-8 Spiroalkyl, 3-8 membered spiro heterocyclic group containing 1-3 heteroatoms, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CR a8 R b8 ) n4 C(O)NR a9 R b9 or -(CH2) n5C(O)NR a10 R b10 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl or C 2-4 Alkynyl, optionally further substituted with halogen, -NS(O)R a1 R b1 、C 1-3 Alkyl or C 3-6 The cycloalkyl group is substituted by one or more substituents.

[0480] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0481] R 1 and R 2 、R 1 and R 11 Linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, C 1-3 Alkyl, C 3-6 substituted by one or more substituents of cycloalkyl, amino or oxo;

[0482] Preferably, R 1 and R 2 、R 1 and R 11 are linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, optionally further C 3-6 substituted by cycloalkyl or oxo;

[0483] More preferably, R 1 and R 2 or R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 The alkyl group is substituted by one or more substituents selected from cycloalkyl, amino or oxo.

[0484] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0485] R a1 、R b1 、R a2 、R b2 、Ra3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 3-6 Bridged cycloalkyl, C 3-6 Spiroalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, wherein the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 3-6 Bridged cycloalkyl, C 3-6 Spiroalkyl, 3-8 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 6-10 Aryl or 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S, optionally further substituted by halogen or C 1-3 The alkyl group is substituted by one or more substituents;

[0486] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 、R a9 、R b9 、R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, methyl, deuterated methyl, cyclopropyl, Optionally, further substituted with fluorine.

[0487] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0488] R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a6 and R b6 or R a8 and R b8 or R a9 and R b9 or R a10 and R b10 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0489] Preferably, R a1 and R b1 or R a2 and R b2 or R a3 and R b3 or R a4 and R b4 or R a6 and R b6 or R a8 and R b8 or R a9 and R b9 or R a10 and R b10 Linked to adjacent atoms to form C 3-6 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0490] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0491] Ring A is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; optionally further substituted by halogen, amino, oxo, mercapto, thio or C 1-6 The alkyl group is substituted by one or more substituents;

[0492] Preferably, ring A is selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thio or C1-3 The alkyl group is substituted by one or more substituents;

[0493] More preferably, ring A is selected from

[0494] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0495] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0496] Preferably, R 4 、R 5 or R 6 Each is independently selected from fluoro, cyano, cyclopropyl or methyl.

[0497] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0498] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R 14 are each independently selected from hydrogen, deuterium, halogen, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0499] Preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R 14 are each independently selected from methyl or cyclopropyl.

[0500] In a further preferred embodiment of the present invention, the compound of formula (XV):

[0501] R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R14 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0502] Preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 13 or R 14 The atoms to which they are attached are linked to form a cyclopropyl group.

[0503] In a further preferred embodiment of the present invention, the compound of general formula (XV) is further represented by general formula (XV-1):

[0504] The object of the present invention is to provide a compound represented by general formula (IV), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0505] in,

[0506] L1 and L2 are each independently selected from a bond, a C2-4 alkenyl group, a C2-4 alkynyl group, -(CH2) n2 -、-(CH2) n3 NR b5 ;

[0507] Ring B is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy or C 1-6 substituted by one or more substituents in a haloalkoxy group;

[0508] R b5 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl;

[0509] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0510] R a1 、R b1、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0511] Or, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0512] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0513] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0514] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0515] n1 is an integer from 0 to 5;

[0516] n2 is an integer from 0 to 5;

[0517] n3 is an integer from 0 to 5.

[0518] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0519] L1 and L2 are each independently selected from a bond, -(CH2) n3 NR b5 .

[0520] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0521] Ring B is selected from C 3-6Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0522] Preferably, ring B is selected from

[0523] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0524] Ring B is selected from C 3-6 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms or 5-10 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thioxo or C 1-3 The alkyl group is substituted by one or more substituents;

[0525] Preferably, ring B is selected from

[0526] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0527] Ring B is selected from C 3-6 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms or 5-10 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thioxo or C 1-3 The alkyl group is substituted by one or more substituents;

[0528] Preferably, ring B is selected from

[0529] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0530] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10Aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0531] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1-3 The alkyl group is substituted by one or more substituents.

[0532] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0533] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0534] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0535] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0536] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aryl or 5-8 membered heteroaryl.

[0537] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0538] R a2 and R b2 、R a3 and R b3 Linked to adjacent atoms to form C 3-8 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0539] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0540] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0541] Preferably, R 4 、R 5 or R 6 are each independently selected from fluoro or methyl.

[0542] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0543] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0544] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from methyl.

[0545] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0546] R 12 Selected from C 1-3 alkyl;

[0547] Preferably, R 12 Selected from methyl.

[0548] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0549] Ring B is selected from

[0550] In a further preferred embodiment of the present invention, the compound of formula (IV):

[0551] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2- 4-alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0552] Preferably, R 12 Selected from C 1-3 Alkyl or C 3-6 Cycloalkyl;

[0553] More preferably, R 12 is selected from methyl or cyclopropyl.

[0554] In a further preferred embodiment of the present invention, the compound of general formula (IV) is further represented by general formula (IV-1):

[0555] The object of the present invention is to provide a compound represented by general formula (VI), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0556] in,

[0557] Ring C is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, -NR a6 S(O)2R b6is substituted by one or more substituents;

[0558] R 10 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0559] or R 10 Linked to the connected C atom to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6-sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0560] R a6 、R b6are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl;

[0561] When R 3 is fluorine, R 4 and R 6 is methyl, R 5 is fluorine, R 7 and R 8 is hydrogen or methyl, R 12 is methyl, ring C is R 10 It cannot be methyl at the same time;

[0562] When R 3 is fluorine, R 4 and R 6 is methyl, R 5 is fluorine, R 7 and R 8 is hydrogen, R 12 is methyl, ring C is R 10 It cannot be hydroxymethyl at the same time;

[0563] When R 3 is fluorine, R 4 and R 6 is methyl, R 5 is fluorine, R 7 and R 8 is hydrogen, R 12 is methyl, ring C is R 10 Cannot be

[0564] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0565] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0566] Or, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0567] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0568] R 7 、R 8 or R 9 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0569] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0570] n1 is an integer from 0 to 5.

[0571] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0572] Ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C6-10 aryl or 5-8 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxyl, cyano, oxo, mercapto, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Haloalkoxy, -NR a6 S(O)2R b6 is substituted by one or more substituents;

[0573] Preferably, ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 selected from N, O or S, 5-8 membered heteroaryl containing 1-3 selected from N, O or S; optionally further substituted by hydroxyl, oxo, -NR a6 S(O)2R b6 is substituted by one or more substituents;

[0574] More preferably, ring C is selected from Optionally further substituted with hydroxyl, oxo, -NR a6 S(O)2R b6 is substituted by one or more substituents.

[0575] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0576] R 10 Selected from hydrogen, deuterium, halogen, C 1-3 alkyl;

[0577] Preferably, R 10 Selected from methyl.

[0578] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0579] R 10 Linked to the connected C atom to form C 3-6 Cycloalkyl;

[0580] Preferably, R 10 The linkage with the attached C atom preferably forms a cyclopropyl group.

[0581] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0582] R a6 、R b6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-3 Alkenyl, C 2-3 Alkynyl, C 3-8 Cycloalkyl, 5-7 membered heterocyclyl, C6-10 aryl, 5-8 membered heteroaryl;

[0583] Preferably, R a6 、R b6 Each is independently selected from hydrogen, methyl.

[0584] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0585] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2- 4-Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0586] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 or C 1-3 The alkyl group is substituted by one or more substituents.

[0587] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0588] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0589] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0590] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0591] R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linking with adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0592] Preferably, R a2 and R b2 、R a3 and R b3 Linked to adjacent atoms to form C 3-8 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0593] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0594] R4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0595] Preferably, R 4 、R 5 or R 6 are each independently selected from fluoro or methyl.

[0596] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0597] R 7 、R 8 、R 9 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0598] Preferably, R 7 、R 8 、R 9 are each independently selected from methyl.

[0599] In a further preferred embodiment of the present invention, the compound of formula (VI):

[0600] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2- 4-alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0601] Preferably, R 12 Selected from C 1-3 alkyl;

[0602] More preferably, R 12 Selected from methyl.

[0603] In a further preferred embodiment of the present invention, the compound of general formula (VI) is further represented by general formula (VI-1):

[0604] The object of the present invention is to provide a compound represented by general formula (VII), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0605] in,

[0606] Ring D is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0607] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0608] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0609] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0610] Or, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0611] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0612] R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0613] R12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0614] n1 is an integer from 0 to 5;

[0615] x is an integer from 0 to 5.

[0616] When R 3 is hydrogen, R 4 and R 6 is methyl, R 5 is fluorine, R 9 、R 10 、R 12 When it is methyl, R 10 Cannot be

[0617] In a further preferred embodiment of the present invention, the compound of general formula (VII):

[0618] Ring D is selected from a 5-12 membered bicyclic fused heterocyclic group, a 5-12 membered bispiro heterocyclic group, and a 5-12 membered bicyclic bridged heterocyclic group;

[0619] Ring D is preferably a 5-8 membered bicyclic fused heterocyclic group, a 5-8 membered bispiro heterocyclic group, or a 5-8 membered bicyclic bridged heterocyclic group;

[0620] Ring D is more preferably

[0621] In a further preferred embodiment of the present invention, the compound of general formula (VII):

[0622] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 is substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl; R 13 A methyl group is further preferred.

[0623] In another embodiment of the present invention, the compound of formula (VII):

[0624] Ring D is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0625] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0626] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0627] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl;

[0628] Or, R a1 and R b1 、R a2 and R b2 、R a3 and R b3 、R a4 and R b4 Linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl and 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0629] Or, R a1 and R b1 、R a2 and Rb2 、R a3 and R b3 、R a4 and R b4 Preferably, they are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl;

[0630] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0631] R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0632] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0633] n1 is an integer from 0 to 5;

[0634] x is an integer from 0 to 5.

[0635] In another embodiment of the present invention, the compound of formula (VII):

[0636] Ring D is selected from 3-8 membered monocyclic heterocyclyl, 5-12 membered bicyclic fused heterocyclyl, 5-12 membered bispiro heterocyclyl, 5-12 membered bicyclic bridged heterocyclyl;

[0637] Preferably, ring D is selected from a 5-6 membered monoheterocyclic group, a 5-10 membered bicyclic fused heterocyclic group, a 5-10 membered bispiro heterocyclic group, and a 5-8 membered bicyclic bridged heterocyclic group;

[0638] More preferably, ring D is selected from

[0639] In another embodiment of the present invention, the compound of formula (VII):

[0640] R 13 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0641] Preferably, R 13 Selected from methyl.

[0642] In another embodiment of the present invention, the compound of formula (VII):

[0643] R 3 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl, 5-8 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2- 4-Alkynyl, C 3-6 substituted by one or more substituents selected from cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl;

[0644] Preferably, R 3 Selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NRa4 R b4 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, optionally further substituted with halogen, -NS(O)R a1 R b1 、C 1-3 The alkyl group is substituted by one or more substituents.

[0645] In another embodiment of the present invention, the compound of formula (VII):

[0646] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0647] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen or methyl.

[0648] In another embodiment of the present invention, the compound of formula (VII):

[0649] R a2 and R b2 、R a3 and R b3 Each independently links with adjacent atoms to form C 3-8 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 heteroatoms.

[0650] In another embodiment of the present invention, the compound of formula (VII):

[0651] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0652] Preferably, R 4 、R 5 or R 6 are each independently selected from fluoro or methyl.

[0653] In another embodiment of the present invention, the compound of formula (VII):

[0654] R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0655] Preferably, R 9 or R 10 are each independently selected from methyl.

[0656] In another embodiment of the present invention, the compound of formula (VII):

[0657] R 12 Selected from C 1-3 alkyl;

[0658] Preferably, R 12 Selected from methyl.

[0659] In another embodiment of the present invention, the compound of formula (VII):

[0660] Ring D is selected from

[0661] In another embodiment of the present invention, the compound of formula (VII):

[0662] R 12 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2- 4-alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0663] Preferably, R 12 Selected from C 1-3 Alkyl or C 3-6 Cycloalkyl;

[0664] More preferably, R 12 is selected from methyl or cyclopropyl.

[0665] In a further preferred embodiment of the present invention, the compound of general formula (VII) is further represented by general formula (VII-1):

[0666] The object of the present invention is to provide a compound represented by general formula (XII), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0667] L1 is selected from a bond, a sub-C 2-4 Alkenyl, C 2-4 Alkynyl, -(CH2) n4 -、-(CH2) n5 NR b5 , the C2-4 alkenyl group, C 2-4 Alkynyl, -(CH2) n4 -or-(CH2) n5 NR b5 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2- 6 alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0668] Ring F is selected from C 3-12 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl;

[0669] R1 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n4 NR a8 C(O)R b8 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0670] or,

[0671] R 1 and the connected C atoms to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0672] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1- 6-deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0673] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0674] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 or R b8 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10Aryl, 5-10 membered heteroaryl, the amino C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0675] n1~n5 are integers of 0~5.

[0676] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0677] Ring F is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 In a further preferred embodiment of the present invention, the compound of formula (XII):

[0678] Preferably, ring F is selected from C 3-10 Cycloalkyl, 5-14 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0679] More preferably, ring F is selected from C 3-6 Bridged cycloalkyl, 8-14 membered tricyclic fused heterocyclic group containing 1-5 heteroatoms, 3-8 membered bridged heterocyclic group containing 1-3 heteroatoms, fused heterocyclic group containing 1-3 heteroatoms, bridged heterocyclic group containing 1-3 heteroatoms, C 6-10 Aryl or a 5-10 membered fused heteroaryl group containing 1-3 heteroatoms;

[0680] More preferably, ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0681] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0682] Ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0683] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0684] Ring F is selected from C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0685] Preferably, ring F is selected from C 3-6 Bridged cycloalkyl, 3-8 membered bridged heterocyclic group containing 1-3 heteroatoms, fused heterocyclic group containing 1-3 heteroatoms, bridged heterocyclic group containing 1-3 heteroatoms, C 6-10 Aryl or a 5-10 membered fused heteroaryl group containing 1-3 heteroatoms;

[0686] More preferably, ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0687] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0688] Ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0689] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0690] Ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl,

[0691] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0692] R 1 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-membered cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 or -(CH2) n1 S(O)2R b5 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0693] Preferably, R 1 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 or -(CH2) n1 S(O)2R b5 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0694] More preferably, R 1 Each independently selected from amino, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 or -(CH2) n1 S(O)2R b5 , the amino group, C 1-3 Alkyl, optionally further substituted with cyano, C 1-3 Alkyl substituted.

[0695] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0696] R 1 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3- 6-membered cycloalkyl, 3-6-membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 、C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0697] Preferably, R 1 Each independently selected from amino, oxo, C 1-3 Alkyl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 、 -(CH2) n1 NR a8 C(O)R b8 , the amino group, C 1-3 Alkyl, optionally further substituted with cyano, C 1-3 Alkyl substituted.

[0698] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0699] R 1 and the connected C atoms to form C 3-6 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl;

[0700] Preferably, R 1 and the connected C atoms further link to form C 3-4 Cycloalkyl.

[0701] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0702] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 alkyl halide;

[0703] Preferably, R 4 、R5 or R 6 are each independently selected from fluoro or methyl.

[0704] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0705] R 7 、R 8 、R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 alkyl halide;

[0706] Preferably, R 7 、R 8 、R 9 or R 10 are each independently selected from methyl.

[0707] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0708] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl, 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0709] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0710] More preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R b5 、R a6 、R b6 、R a7 、R b7 、Ra8 、R b8 Each is independently selected from hydrogen, deuterium, halogen, phenyl or methyl.

[0711] In a further preferred embodiment of the present invention, the compound of general formula (XII):

[0712] R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 are each independently selected from hydrogen, deuterium, halogen, amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 alkyl halide;

[0713] Preferably, R a1 、R b1 、R a2 、R b2 、R a3 、R b3 、R a4 、R b4 、R a5 、R a6 、R b6 、R a7 、R b7 、R a8 、R b8 Each is independently selected from hydrogen, deuterium, halogen, and methyl.

[0714] In a further preferred embodiment of the present invention, the compound of general formula (XII) is further represented by general formula (XII-1):

[0715] The object of the present invention is to provide a compound represented by general formula (XVII), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0716] in,

[0717] R 3 or R 13 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0718] L1, L2 or L3 are each independently selected from a bond, C 2-4 Alkenylene, C 2-4 Alkynylidene or -(CH2) n1 -;

[0719] Ring B is selected from C 3-12Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0720] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1- 6-sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0721] R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6-deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0722] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0723] Or, R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0724] or,

[0725] R 7 and R 8 、R 14 and R 15 、R 10 and R 12 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0726] Ring E is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14Aryl or 5-14 membered heteroaryl;

[0727] Alternatively, ring E is

[0728] Ring C is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 substituted by one or more substituents in a deuterated haloalkoxy group;

[0729] n1, n2 or m1 are each independently selected from 0, 1, 2, 3, 4 or 5.

[0730] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0731] R 3 or R 13 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0732] Preferably, R 3 or R 13 Each independently selected from hydrogen, deuterium, fluorine, chlorine, bromine, methyl or cyclopropyl, wherein the methyl or cyclopropyl group is optionally further substituted by halogen or C 1-3 The alkyl group is substituted by one or more substituents.

[0733] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0734] Ring B is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 atoms selected from N, O or S; optionally further substituted by halogen, amino, oxo, mercapto, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0735] Preferably, ring B is selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered heteroaryl containing 1-3 N, O or S atoms; optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents;

[0736] More preferably, ring B is selected from Optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents.

[0737] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0738] R 4 、R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0739] Preferably, R 4 、R 5 or R 6 Each independently selected from fluorine, cyano, cyclopropyl or methyl, wherein the cyclopropyl or methyl is optionally further substituted by halogen, amino, oxo, thio or C 1-3 The alkyl group is substituted by one or more substituents.

[0740] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0741] R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-3 Alkyl, C1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6- 10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0742] Preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, cyano, C 2-4 Alkynyl, C 3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , the C 2-4 Alkynyl, C3-6 Cycloalkyl, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl or -(CH2) m1 OR c1 , optionally further substituted with one or more substituents selected from deuterium, deuterated methyl, methyl, cyclopropyl or oxo;

[0743] More preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 Each is independently selected from cyano, methyl, fluoro, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , the methyl, cyclopropyl, ethynyl or -(CH2) m1 OR c1 , optionally further substituted with one or more substituents selected from deuterium, deuterated methyl, methyl, cyclopropyl or oxo.

[0744] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0745] R c1 Selected from hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1- 3 haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0746] Preferably, R c1 is selected from fluorine, methyl, cyano, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane, wherein the methyl, difluoromethyl, trifluoromethyl, ethynyl, methylthio, amino, cyclopropyl or oxetane is optionally further substituted with one or more substituents selected from halogen, methoxy or deuterated methyl.

[0747] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0748] R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0749] Preferably, R 7 、R 8 、R 9 、R 10 、R 12 、R 14 or R 15 The atoms to which they are attached are linked to form a cyclopropyl group.

[0750] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0751] R 10 and R 12 The atoms connected to it form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl;

[0752] R 10 and R 12 The atoms connected to it form a C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S;

[0753] Preferably, R 10 and R 12 The atoms connected to it form a link

[0754] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0755] R 7 and R 8 、R 14 and R 15 、R 10 and R 12 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1- 3-deuterated sulfanyl, C1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0756] Preferably, R 7 and R 8 、R 14 and R 15 、R 10 and R 12 The atoms connected to them form cyclopropyl groups, Optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, nitro, hydroxy, cyano, oxo, thioxo, methyl or ethyl.

[0757] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0758] Ring E is selected from C 3-8 Cycloalkyl, 3-10 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 aryl or a 5-10 membered heteroaryl group containing 1-3 atoms selected from N, O or S;

[0759] Preferably, ring E is selected from

[0760] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0761] Ring E is

[0762] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0763] Ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S; optionally further substituted by halogen, amino, nitro, hydroxy, cyano, oxo, mercapto, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Deuterated haloalkyl, C 1-3-Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1- 3 haloalkoxy or C 1-3 substituted by one or more substituents in a deuterated haloalkoxy group;

[0764] Preferably, ring C is selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 selected from N, O or S, or 5-8 membered heteroaryl containing 1-3 selected from N, O or S; optionally further substituted by hydroxyl, thioxo, oxo or C 1-3 substituted by one or more substituents in a haloalkoxy group;

[0765] More preferably, ring C is selected from Optionally further substituted with one or more substituents selected from the group consisting of hydroxy, thio or oxo.

[0766] In a further preferred embodiment of the present invention, the compound of formula (XVII):

[0767] R 13 Selected from C 1-6 Deuterated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Deuterated alkoxy, C 1-6 Deuterated haloalkoxy, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 1-6 Deuterated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Deuterated alkoxy, C 1-6 Deuterated haloalkoxy, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Halogenated alkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C6-10 substituted by one or more substituents of aryl or 5-10 membered heteroaryl;

[0768] Preferably, R 13 Selected from C 1-3 Deuterated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Deuterated sulfanyl, C 1-3 Deuterated alkoxy, C 1-3 Deuterated haloalkoxy, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the C 1- 3-deuterated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Deuterated sulfanyl, C 1-3 Deuterated alkoxy, C 1-3 Deuterated haloalkoxy, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Halogenated alkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 substituted by one or more substituents in aryl or 5-8 membered heteroaryl;

[0769] More preferably, R 13 Selected from -CD3 or cyclopropyl, wherein the -CD3 or cyclopropyl is optionally further substituted by deuterium, halogen or C 1-3 The alkyl group is substituted by one or more substituents;

[0770] More preferably, R 13 Selected from cyclopropyl, optionally further substituted by deuterium, halogen or C 1-3 The alkyl group is substituted by one or more substituents.

[0771] In a further preferred embodiment of the present invention, the compound of general formula (XVII) is further represented by general formula (XVII-1):

[0772] The present invention further provides a compound represented by the general formula (IN-A), (IN-B) or (IN-C), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

[0773] Among them, in the general formula (IN-A), R 13 , Ring A, Ring B, L1, L2, R 4 、R 5 、R 6 、R 9 is as defined in formula (XIX);

[0774] In the general formula (IN-B), ring C, ring D, ring E, L3, R 1 、R 7 、R 8 、R 14 、R 15 , n is as defined in general formula (XIX);

[0775] In the general formula (IN-C), ring F, ring B, L1, L2, R 1 、R 4 、R 5 、R 6 、R 9 , x is as defined in the general formula (XVI).

[0776] In a further preferred embodiment of the present invention, the compound of general formula (IN-A): R 13 Selected from C 3-8 Cycloalkyl, C 6- 10 Aryl, 5-10 membered heteroaryl; the C 3-8 Cycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, optionally further deuterated, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 The alkyl group is substituted by one or more substituents.

[0777] In a further preferred embodiment of the present invention, the compound of general formula (IN-B): Ring D is selected from C 3-8 Bicyclic cycloalkyl, 3-8 membered bicyclic heterocyclic group or 5-10 membered bicyclic heteroaryl containing 1-3 atoms selected from N, O or S; preferably, ring D is selected from C 3-6 Bicyclic cycloalkyl, 3-8 membered bicyclic heterocyclic group containing 1-3 N, O or S atoms or 5-8 membered bicyclic heteroaryl containing 1-3 N, O or S atoms; preferably, ring D is selected from

[0778] In a further preferred embodiment of the present invention, in the compound of the general formula (IN-C), ring F is selected from an 8-14 membered tricyclic fused heterocyclic group containing 1-5 heteroatoms.

[0779] The present invention further provides a method of preparing the above-mentioned general formula and compound, comprising the following steps:

[0780] Among them: Ring A, Ring B, Ring C, Ring D, Ring E, L1, L2, L3, R 1 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 13 、R 14 、R 15 、R 16 is as defined in formula (XIX);

[0781] General formula (IN-A) and general formula (IN-B) react under the action of a condensing agent and a base to obtain general formula (XIX);

[0782] The condensing agent is selected from EDC, DIC, DCC, TBTU, HATU, HBTU, HCTU, DEPBT, PyBOP or PyAOP;

[0783] The base is selected from DIPEA, DIEA, Et3N, NMP, DBU or DABCO.

[0784] In a further preferred embodiment of the present invention, in the preparation method, the condensing agent is selected from HATU; and the base is selected from DIPEA.

[0785] In a further preferred embodiment of the present invention, the preparation method is carried out under solvent conditions, and the reaction solvent is selected from N,N-dimethylformamide, N,N-dimethylacetamide, tetrahydrofuran, acetonitrile or dichloromethane; preferably N,N-dimethylformamide.

[0786] The present invention further provides a method of preparing the above-mentioned general formula and compound, comprising the following steps:

[0787] Among them: Ring F, Ring B, Ring C, Ring E, L1, L2, L3, R 1 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R12 、R 13 、R 14 , x is as defined in formula (XVI);

[0788] General formula (IN-C) and general formula (IN-D) react under the action of a condensing agent and a base to obtain general formula (XVI);

[0789] The condensing agent is selected from EDC, DIC, DCC, TBTU, HATU, HBTU, HCTU, DEPBT, PyBOP or PyAOP; preferably HATU;

[0790] The base is selected from DIPEA, DIEA, Et3N, NMP, DBU or DABCO.

[0791] In a further preferred embodiment of the present invention, in the preparation method, the condensing agent is selected from HATU; and the base is selected from DIEA.

[0792] In a further preferred embodiment of the present invention, the preparation method is carried out under solvent conditions, and the reaction solvent is selected from N,N-dimethylformamide, N,N-dimethylacetamide, tetrahydrofuran, acetonitrile or dichloromethane; preferably N,N-dimethylformamide.

[0793] The present invention further relates to a pharmaceutical composition comprising a therapeutically effective dose of any compound of the general formula shown, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers, diluents or excipients.

[0794] In certain embodiments of the present invention, the pharmaceutical composition, calculated as the free base, the weight percentage of the compound, its prodrug, its stereoisomer or its pharmaceutically acceptable salt is 0.1% to 95%, preferably 5-70%, for example 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10% or 5%.

[0795] In certain embodiments of the present invention, the pharmaceutical composition is selected from tablets, capsules, liquid preparations or injections, and preferably further comprises a filler, optionally a disintegrant, or further comprises one or more of a glidant or a lubricant.

[0796] In certain embodiments of the present invention, the pharmaceutical composition is a rapid-release formulation or a sustained-release formulation.

[0797] In certain embodiments of the present invention, the pharmaceutical composition, calculated as the free base, the unit dose of the compound, its prodrug, its stereoisomer or its pharmaceutically acceptable salt is 1-1000 mg, preferably 1-500 mg, or preferably 1 mg, 2 mg, 3 mg, 5 mg, 10 mg, 20 mg, 40 mg, 50 mg, 60 mg, 80 mg, 100 mg, 200 mg, 300 mg, 400 mg or 500 mg.

[0798] In certain embodiments of the present invention, the compound, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof, can be administered by any convenient method, for example, by oral, parenteral, buccal, sublingual, nasal, rectal, intrathecal or transdermal administration, and the pharmaceutical composition adjusted accordingly.

[0799] In certain embodiments of the present invention, the compound, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof can be formulated into liquid or solid preparations, such as syrups, suspensions, emulsions, tablets, capsules, powders, granules, or lozenges.

[0800] The present invention further relates to the use of any compound of the general formula shown, its prodrug, its stereoisomer or pharmaceutically acceptable salt, or the pharmaceutical composition in the preparation of GLP-1 receptor agonist drugs.

[0801] The present invention further relates to the use of a compound represented by the general formula, a prodrug thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof in the preparation of a medicament for treating metabolic-related diseases, wherein the disease is selected from diabetes, obesity, or non-alcoholic steatohepatitis-related diseases or other related diseases caused by diabetes, obesity, or non-alcoholic steatohepatitis.

[0802] The present invention further relates to a method for using the compound represented by the general formula, its prodrug, its stereoisomer or pharmaceutically acceptable salt, or its pharmaceutical composition in the preparation of drugs for treating metabolic diseases and related diseases.

[0803] The present invention also relates to a method for treating, preventing and / or treating metabolic-related diseases, which comprises administering to a patient a therapeutically effective dose of a compound represented by the general formula, a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof.

[0804] The present invention also provides methods of using the compounds or pharmaceutical compositions of the present invention to treat disease conditions, including but not limited to conditions associated with GLP-1 receptor modulators.

[0805] The present invention also relates to a method for treating metabolic disease-related diseases in mammals, comprising administering to the mammal a therapeutically effective amount of a compound of the present invention or a pharmaceutically acceptable salt, ester, prodrug, solvate, hydrate or derivative thereof.

[0806] Detailed Description of the Invention

[0807] Unless otherwise stated, the terms used in the specification and claims have the following meanings.

[0808] The term "alkyl" refers to a saturated aliphatic hydrocarbon group, which is a straight or branched chain group containing 1 to 20 carbon atoms, preferably an alkyl group containing 1 to 8 carbon atoms, more preferably an alkyl group containing 1 to 6 carbon atoms, and most preferably an alkyl group containing 1 to 3 carbon atoms. Non-limiting examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 2-methylbutyl, 3-methylbutyl, n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl, n-heptyl, 2-methylhexyl, 3-methylhexyl, 4-methylhexyl, 5-methylhexyl, 2, 3-Dimethylpentyl, 2,4-dimethylpentyl, 2,2-dimethylpentyl, 3,3-dimethylpentyl, 2-ethylpentyl, 3-ethylpentyl, n-octyl, 2,3-dimethylhexyl, 2,4-dimethylhexyl, 2,5-dimethylhexyl, 2,2-dimethylhexyl, 3,3-dimethylhexyl, 4,4-dimethylhexyl, 2-ethylhexyl, 3-ethylhexyl, 4-ethylhexyl, 2-methyl-2-ethylpentyl, 2-methyl-3-ethylpentyl, n-nonyl, 2-methyl-2-ethylhexyl, 2-methyl-3-ethylhexyl, 2,2-diethylpentyl, n-decyl, 3,3-diethylhexyl, 2,2-diethylhexyl, and various branched-chain isomers thereof. More preferred are lower alkyl groups containing 1 to 6 carbon atoms, non-limiting examples of which include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 2-methylbutyl, 3-methylbutyl, n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl, and the like. The alkyl group may be substituted or unsubstituted. When substituted, the substituent may be substituted at any available point of attachment. The substituent is preferably one or more of the following groups independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, halogen, mercapto, hydroxy, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkoxy, heterocycloalkoxy, cycloalkylthio, heterocycloalkylthio, oxo, carboxyl or carboxylate groups. Methyl, ethyl, isopropyl, tert-butyl, haloalkyl, deuterated alkyl, alkoxy-substituted alkyl and hydroxy-substituted alkyl are preferred.

[0809] The term "alkylene" means that one hydrogen atom of an alkyl group is further substituted, for example: "methylene" refers to -CH2-, "ethylene" refers to -(CH2)2-, "propylene" refers to -(CH2)3-, "butylene" refers to -(CH2)4-, etc.

[0810] The term "alkenyl" refers to an alkyl group as defined above consisting of at least two carbon atoms and at least one carbon-carbon double bond, for example, ethenyl, 1-propenyl, 2-propenyl, 1-, 2- or 3-butenyl, etc. The alkenyl group may be substituted or unsubstituted, and when substituted, the substituent is preferably one or more of the following groups independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, halogen, mercapto, hydroxy, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkoxy, heterocycloalkoxy, cycloalkylthio, heterocycloalkylthio.

[0811] The term "alkenylene" refers to an alkenyl group with one hydrogen atom further substituted, for example, "vinylene" refers to -CH2=CH2-, "propenylene" refers to -CH2-=CH2-CH2-, etc. Alkenylene can be substituted or unsubstituted. When substituted, the substituent is preferably one or more of the following groups independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, halogen, mercapto, hydroxy, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkoxy, heterocycloalkoxy, cycloalkylthio, heterocycloalkylthio. The term "cycloalkyl" refers to a saturated or partially unsaturated monocyclic or polycyclic hydrocarbon substituent, the cycloalkyl ring containing 3 to 20 carbon atoms, preferably 3 to 12 carbon atoms, more preferably 3 to 8 carbon atoms, and even more preferably 3 to 6 carbon atoms. Non-limiting examples of monocyclic cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cyclohexadienyl, cycloheptyl, cycloheptatrienyl, cyclooctyl, and the like; polycyclic cycloalkyl groups include spiro, fused, and bridged cycloalkyl groups, preferably cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl.

[0812] The term "spiroalkyl" refers to a polycyclic group having a carbon atom (called a spiro atom) shared between 5 to 20 monocyclic rings, which may contain one or more double bonds, but no ring has a completely conjugated π electron system. Preferably, it is 6 to 14 yuan, more preferably 7 to 10 yuan. According to the number of spiro atoms shared between the rings, the spiroalkyl group is divided into a single spiroalkyl group, a double spiroalkyl group or a multi-spiroalkyl group, preferably a single spiroalkyl group and a double spiroalkyl group. More preferably, it is a 4 yuan / 4 yuan, 4 yuan / 5 yuan, 4 yuan / 6 yuan, 5 yuan / 5 yuan or 5 yuan / 6 yuan single spiroalkyl group. Non-limiting examples of spiroalkyl groups include:

[0813] It also includes spirocycloalkyl groups that share a spiro atom with a heterocycloalkyl group. Non-limiting examples include:

[0814] The term "fused cycloalkyl" refers to a 5 to 20-membered, all-carbon polycyclic group in which each ring in the system shares a pair of adjacent carbon atoms with the other rings in the system, wherein one or more rings may contain one or more double bonds, but no ring has a completely conjugated π electron system. Preferably, it is 6 to 14 members, more preferably 7 to 10 members. Depending on the number of constituent rings, it can be divided into bicyclic, tricyclic, tetracyclic or polycyclic fused cycloalkyl groups, preferably bicyclic or tricyclic, more preferably 5-membered / 5-membered or 5-membered / 6-membered bicyclic alkyl groups. Non-limiting examples of fused cycloalkyl groups include:

[0815] The term "bridged cycloalkyl" refers to a 5-20 membered, all-carbon polycyclic group in which any two rings share two carbon atoms that are not directly connected, which may contain one or more double bonds, but no ring has a completely conjugated π electron system. Preferably, it is 6-14 members, more preferably 7-10 members. Depending on the number of constituent rings, it can be classified as a bicyclic, tricyclic, tetracyclic or polycyclic bridged cycloalkyl group, preferably a bicyclic, tricyclic or tetracyclic group, more preferably a bicyclic or tricyclic group. Non-limiting examples of bridged cycloalkyl groups include:

[0816] The cycloalkyl ring may be fused to an aryl, heteroaryl or heterocycloalkyl ring, wherein the ring attached to the parent structure is a cycloalkyl, non-limiting examples of which include indanyl, tetrahydronaphthyl, benzocycloheptanyl, etc. The cycloalkyl group may be optionally substituted or unsubstituted, and when substituted, the substituents are preferably one or more of the following groups independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, halogen, mercapto, hydroxy, nitro, cyano, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkoxy, heterocycloalkoxy, cycloalkylthio, heterocycloalkylthio, oxo, carboxyl or carboxylate.

[0817] The term "heterocyclyl" refers to a saturated or partially unsaturated monocyclic or polycyclic hydrocarbon substituent containing 3 to 20 ring atoms, one or more of which is selected from nitrogen, oxygen or S(O) m (wherein m is an integer from 0 to 2) heteroatoms, but excluding the ring portion of -OO-, -OS- or -SS-, the remaining ring atoms are carbon. Preferably, it contains 3 to 12 ring atoms, of which 1 to 4 are heteroatoms; more preferably, it contains 3 to 10 ring atoms; further preferably, it contains 3 to 8 ring atoms. Non-limiting examples of monocyclic heterocyclic groups include pyrrolidinyl, azetidinyl, oxetanyl, oxetanyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothienyl, dihydroimidazolyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperazinyl and pyranyl; preferably, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydrofuranyl, pyrazolidinyl, morpholinyl, Piperazinyl and pyranyl; more preferably pyrrolidinyl, azetidinyl, oxetanyl, oxahenyl, piperidinyl, Piperazinyl and pyranyl. Polycyclic heterocyclic groups include spirocyclic, fused-ring and bridged heterocyclic groups; wherein the spirocyclic, fused-ring and bridged heterocyclic groups are optionally connected to other groups through single bonds, or further connected to other cycloalkyl, heterocyclic, aryl and heteroaryl groups through any two or more atoms on the ring.

[0818] The term "spiroheterocyclyl" refers to a polycyclic heterocyclic group in which the monocyclic rings of 5 to 20 members share one atom (called a spiro atom), wherein one or more ring atoms are selected from nitrogen, oxygen or S(O) m (wherein m is an integer 0 to 2) heteroatom, and the remaining ring atoms are carbon. It may contain one or more double bonds, but no ring has a completely conjugated π electron system. It is preferably 6 to 14 members, more preferably 7 to 10 members. According to the number of shared spiral atoms between the rings, the spiro heterocyclic group is divided into a monospiro heterocyclic group, a dispiro heterocyclic group or a polyspiro heterocyclic group, preferably a monospiro heterocyclic group and a dispiro heterocyclic group. It is more preferably 4 yuan / 4 yuan, 4 yuan / 5 yuan, 4 yuan / 6 yuan, 5 yuan / 5 yuan or 5 yuan / 6 yuan monospiro heterocyclic group. Non-limiting examples of spiro heterocyclic groups include:

[0819] The term "fused heterocycl...

Claims

1. A compound represented by general formula (XIX), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: R 13 Selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1- 6-deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; L1, L2 or L3 are each independently selected from a bond, C 2-4 Alkenylene, C 2-4 Alkyne or -(CH2) n1 -; Ring A is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; Ring B is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 is substituted by one or more substituents in a deuterated haloalkoxy group; Ring C is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 is substituted by one or more substituents in a deuterated haloalkoxy group; Ring D is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; Ring E is selected from C 3-14 Cycloalkyl, 3-14 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 14 , R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic ring Base, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m1 OR c1 or (=C)R c3 R c4 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R c1 , R c3 or R c4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R a1 , R a 2. R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Or, R 9 or R 16 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl; Preferably, R 9 or R 16 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or a 5-8 membered heteroaryl group containing 1-3 atoms selected from N, O or S; More preferably, R 9 or R 16 The atoms connected to them are linked to form a cyclopropyl group; Or, when n is not 1, R 1 and R 1 , R 4 and R 5 , R 5 and R 6 , R 7 and R 8 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 is substituted by one or more substituents in a membered heteroaryl group; n, n1, m1, m2, m3 or m4 are each independently selected from 0, 1, 2, 3, 4 or 5.

2. The compound, prodrug, stereoisomer or pharmaceutically acceptable salt thereof according to claim 1, characterized in that: The general formula (XIX) is further represented by the general formula (XVIII): in, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , R 14 , R 15 or R 16 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , the amino group, C 1-3 Alkyl, C 1- 3-deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; R c1 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , the amino group, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, -(CH2) m2 OR c2 、-(CH2) m3 C(O)NR a1 R b1 or -(CH2) m4 C(O)OR a2 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Haloalkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; R a1 , R a2 , R b1 or R c2 Each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, the amino, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy Base, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; or, R 1 and R 10 , R 2 and R 12 , R 4 and R 5 , R 5 and R 6 , R 7 and R 8 , R 10 and R 12 The atoms connected to them form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 atoms selected from N, O or S, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 atoms selected from N, O or S, optionally further substituted by deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1- 3-deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; Preferably, R 1 and R 10 , R 2 and R 12 , R 4 and R 5 , R 5 and R 6 , R 7 and R 8 , R 10 and R 12 The atoms connected to them form cyclopropyl groups, Optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, nitro, hydroxyl, cyano, oxo, thioxo, methyl or ethyl; R 13 , L1, L2, L3, ring A, ring B, ring C, and ring E are as described in claim 1; n1, m1, m2, m3 or m4 are each independently selected from 0, 1, 2, 3, 4 or 5.

3. The compound according to claim 2, its prodrug, its stereoisomer or its pharmaceutically acceptable salt, characterized in that: R 13 Selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, C 1-6 Deuterated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Deuterated alkoxy or C 1-6 Deuterated haloalkoxy, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-6 Deuterated alkyl, C 1-6 Deuterated haloalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Deuterated alkoxy or C 1-6 Deuterated haloalkoxy, optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R 13 Selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, C 1-3 Deuterated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Deuterated sulfanyl, C 1-3 Deuterated alkoxy or C 1-3 Deuterated haloalkoxy, the C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl, 5-8 membered heteroaryl, C 1-3 Deuterated alkyl, C 1-3 Deuterated haloalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Deuterated sulfanyl, C 1-3 Deuterated alkoxy or C 1-3 Deuterated haloalkoxy, optionally further substituted with deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; More preferably, R 13 is selected from cyclopropyl or -CD3, wherein the cyclopropyl or -CD3 is optionally further substituted by deuterium, halogen or C 1-3 The alkyl group is substituted by one or more substituents; More preferably, R 13 is selected from cyclopropyl, wherein the cyclopropyl is optionally further substituted by deuterium, halogen or C 1-3 The alkyl group is substituted with one or more substituents.

4. The compound, its prodrug, its stereoisomer or its pharmaceutically acceptable salt according to claim 2, characterized in that the general formula (XVIII) is further represented by general formula (XVIII-A): Alternatively, the general formula (XVIII) is further represented by general formula (XVIII-B): in, Ring A, Ring B, Ring C, Ring E, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , R 14 , R 15 , R 16 , L1, L2 and L3 are defined as in claim 2.

5. The compound, prodrug, stereoisomer or pharmaceutically acceptable salt thereof according to claim 1, characterized in that: The general formula (XIX) is further represented by the general formula (V): in, R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl and 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; Preferably, R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 1-3 Alkyl, C 1-3 Sulfanyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms; optionally further substituted by halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl and C 1-3 substituted by one or more substituents in the alkoxy group; More preferably, R 4 , R 5 or R 6 Each independently selected from fluorine, methyl, cyano, ethynyl, methylthio, amino, cyclopropyl , oxetane; optionally further substituted by halogen, methoxy, deuterated methyl; Or, R 5 and R 6 Link Form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl and 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; R 3 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl and 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; R a1 , R b1 , R a2 , R b2 , R a3 , R b3 , R a4 , R b4 or R a5 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl; Or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 Link Form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl and 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; Preferably, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 Link Form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl; R 7 , R 8 , R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; R 12 Selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aromatic, 5-10 membered heteroaryl, hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-haloalkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2- 6-alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 substituted by one or more substituents of aryl and 5-10 membered heteroaryl; n1 is an integer from 0 to 5; When R 7 , R 8 is hydrogen, R 9 , R 10 , R 12 is methyl, R 3 , R 5 When it is fluorine, R 4 and R 6 Not methyl at the same time; When R 7 and R 8 is hydrogen, R 9 , R 10 , R 12 is methyl, R 3 is hydrogen, R 5 When it is a halogen, R 4 and R 6 Not methyl at the same time; When R 7 , R 8 , R 9 , R 10 , R 12 is methyl, R 5 When it is fluorine, R 4 When R is halogen, trifluoromethyl or cyclopropyl, 6 Not hydrogen; When R 7 , R 8 , R 9 , R 10 is methyl, R 12 is a deuterated methyl group, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is deuterated methyl, R 6 Not a deuterated methyl group; When R 4 , R 6 , R 7 , R 8 , R 9 , R 10 is methyl, R 3 , R 5 When is fluorine, R 12 Not a deuterated methyl group; When R 7 , R 8 , R 9 , R 10 , R 12 is methyl, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is methyl, R 6 Not A base; When R 7 , R 8 , R 9 , R 10 is methyl, R 12 is a deuterated methyl group, R 3 is fluorine, R 5 When it is a halogen, R 4 When it is deuterated methyl, R 6 Not a deuterated methyl group; When R 4 , R 6 , R 7 , R 8 , R 9 , R 10 is methyl, R 3 , R 5 When is fluorine, R 12 It is not a deuterated methyl group.

6. The compound, prodrug, stereoisomer or pharmaceutically acceptable salt thereof according to claim 1, characterized in that: The general formula (XIX) is further represented by the general formula (V): in, R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-1 0 aromatic or 5-10 membered heteroaryl, the amino, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, cyano, C 1-3 Alkyl, C 1-3 Sulfanyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl or 3-6 membered heterocyclic group containing 1-3 N, O or S atoms; optionally further substituted by halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl or C 1-3 substituted by one or more substituents in the alkoxy group; More preferably, R 4 , R 5 or R 6 Each is independently selected from fluoro, methyl, cyano, ethynyl, methylthio, amino, cyclopropyl or oxetane; optionally further substituted by halogen, methoxy or deuterated methyl; Or, R 5 and R 6 Links with adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6-sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 3 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n2 R a5 R b5 or The amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R a1 , R b1 , R a2 , R b2 , R a3 , R b3 , R a4 , R b4 , R a5 , R b5 , R a6 or R b6 are each independently selected from hydrogen, deuterium, Halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; Or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 , R a5 and R b5 , R a6 and R b6 They are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 7 , R 8 , R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1- 6-Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R 7 , R 8 , R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic, 5-8 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; R c1 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R c1 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2- 4-Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 aromatic or 5-8 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Alkoxy, C 1-3 Halogenated alkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; Or, R 7 , R 8 , R 9 or R 10 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6- 12 Aryl or 5-12 membered heteroaryl; R 12 Selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic, 5-10 membered heteroaryl, hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, -(CH2) n2 R a5 R b5 or Optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6 alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; or, R 10 The atoms connected to it and the adjacent atoms link to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl; Preferably, R 10 The atoms connected to it and the adjacent atoms link to form C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl; More preferably, R 10 The atoms connected to it and the adjacent atoms link to form n1-n3 are integers from 0 to 5; m1 is an integer ranging from 0 to 5.

7. The compound according to claim 1, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof, wherein: The compound structure is as follows:

8. A compound represented by general formula (XVI), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: in, Ring F is selected from 3-18 membered heterocyclic group, C 3-18 Cycloalkyl, C 6-18 Aryl or 5-18 membered heteroaryl; Preferably, ring F is selected from a 3-14 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 3-12 Cycloalkyl, C 6- 14 Aryl or 5-14 membered heteroaryl containing 1-3 heteroatoms selected from N, O or S; More preferably, ring F is selected from a 5-14 membered heterocyclic group containing 1-3 heteroatoms selected from N, O or S, C 3-10 Cycloalkyl, C 6-10 Aryl or a 5-10 membered heteroaryl group containing 1-3 heteroatoms selected from N, O or S; More preferably, ring F is selected from an 8-14 membered tricyclic fused heterocyclic group containing 1-5 heteroatoms, 3-6 bridged cycloalkyl, 3-8 membered bridged heterocyclic group containing 1-3 heteroatoms, fused heterocyclic group containing 1-3 heteroatoms, bridged heterocyclic group containing 1-3 heteroatoms, C 6-10 Aryl or 5-10 membered fused heteroaryl containing 1-3 heteroatoms; More preferably, ring F is selected from phenyl, pyridyl, pyrimidinyl, thiazolyl, pyridazinyl, oxazolyl, morpholinyl, Ring B is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 is substituted by one or more substituents in a deuterated haloalkoxy group; Ring C is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl; optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, thiol, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Haloalkoxy or C 1-6 is substituted by one or more substituents in a deuterated haloalkoxy group; Ring E is selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1- 6-Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; L1, L2 or L3 are each independently selected from a bond, a sub-C 2-4 Alkenyl, C 2-4 Alkynyl, -(CH2) n1 -or-(CH2) n5 NR b5 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1- 6 alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 1 Each independently selected from Hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 O(CH2) n2 R a5 、-(CH2) n1 C(O)NR a6 R b6 、-(CH2) n1 P(O)R a3 R b3 , -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 , optionally further Halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6-deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; or, R 1 Link to the connected atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further Deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, thio, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 、-NR a5 S(O)NR a4 R b4 、-(CH2) n1 S(O)2R a5 、-(CH2) n1 O(CH2) n2 P b5 , -(CH2) n1 NR a8 C(O)R b8 、-(CR a8 R b8 ) n4 C(O)NR a9 R b9 、-(CH2) n1 S(O)2R b5 or -(CH2) n5 C(O)NR a10 R b10 One or more substituents in replace; R a1 , R b1 , R a2 , R b2 , R a3 , R b3 , R a4 , R b4 , R a5 , R a6 , R b6 , R a7 , R b7 , R a8 , R b8 , R a9 , R b9 , R a10 or R b10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 , R a6 and R b6 , R a8 and R b8 , R a9 and R b9 , R a10 and R b10 They are linked to adjacent atoms to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1- 6-deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 7 , R 8 , R 9 , R 10 , R 12 , R 13 , R 14 or R 15 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1- 6-haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R c1 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1-6 Halogenated alkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Or, R 7 , R 8 , R 9 , R 10 , R 12 , R 13 , R 14 or R 15 The atoms connected to them form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl; or, R 10 and R 12 The atoms connected to it form a C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl; Preferably, R 10 and R 12 The atoms connected to it form a C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms; n1-n5, m1 or x are each independently selected from 0, 1, 2, 3, 4 or 5.

9. The compound, prodrug, stereoisomer or pharmaceutically acceptable salt thereof according to claim 8, characterized in that: The general formula (XVI) is further shown in the general formula (XVI-A): in, Further As shown, optionally further halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl; Ring M1, Ring M2, Ring M3, Ring M4, Ring M5, Ring M6, Ring M7, Ring M8, M9 or M 10 Each independently selected from C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Deuterated haloalkyl, C 1- 6-Hydroxyalkyl, C 1-6 Deuterated hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Deuterated sulfanyl, C 1-6 Alkoxy, C 1-6 Deuterated alkoxy, C 1- 6-haloalkoxy, C 1-6 Deuterated haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7, ring M8, M9 or M 10 Each independently selected from C 3-8 Cycloalkyl, 3-8 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-10 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 1-3 Haloalkyl, C 1-3 Deuterated haloalkyl, C 1-3 Hydroxyalkyl, C 1-3 Deuterated hydroxyalkyl, C 1-3 Sulfanyl, C 1-3 Deuterated sulfanyl, C 1-3 Alkoxy, C 1-3 Deuterated alkoxy, C 1-3 Halogenated alkoxy, C 1-3 Deuterated haloalkoxy, C 2-4 Alkenyl, C 2-4 Alkynyl, C 3-6 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-8 membered heteroaryl; More preferably, ring M1, ring M2, ring M3, ring M4, ring M5, ring M6, ring M7, ring M8, M9 or M 10 Each independently selected from C 3-6 Cycloalkyl, 3-6 membered heterocyclic group containing 1-3 N, O or S atoms, C 6-10 Aryl or 5-8 membered heteroaryl containing 1-3 N, O or S atoms, optionally further substituted with halogen, methoxy, C 1-3 Cycloalkyl, C 3-6 substituted by one or more substituents of cycloalkyl or deuterated methyl; Ring B, Ring C, Ring E, L1, L2, L3, R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , R 13 , R 14 The definition as set forth in claim 9.

10. The compound, prodrug, stereoisomer or pharmaceutically acceptable salt thereof according to claim 8, characterized in that: The general formula (XVI) is further represented by the general formula (II): in, R 1 and R 2 , R 1 and R 11 They are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R 1 and R 2 , R 1 and R 11 They are linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl, optionally further substituted by one or more substituents selected from halogen, amino or oxo; More preferably, R 1 and R 2 , R 1 and R 11 Each of them is linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, which is optionally further substituted by an oxo group; R 3 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R a1 , R b1 , R a2 , R b2 , R a3 , R b3 , R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; Or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 They are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 They are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-6 membered heterocyclic group, C 6-10 Aryl or 5-8 membered heteroaryl; R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 deuterium Alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 7 , R 8 , R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; n1 is an integer from 0 to 5.

11. The compound according to claim 8, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof, characterized in that: The general formula (XVI) is further represented by the general formula (II): in, R 1 and R 2 , R 1 and R 11 They are linked to adjacent atoms to form C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, the C 3-12 Cycloalkyl, 3-12 membered heterocyclic group, C 6-14 Aryl or 5-14 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; Preferably, R 1 and R 2 , R 1 and R 11 They are linked to adjacent atoms to form C 3-6 Cycloalkyl, 3-10 membered heterocyclic group, C 6- 10 Aryl or 5-8 membered heteroaryl, optionally further substituted with halogen, C 1-3 Alkyl, C 3-6 is substituted by one or more substituents of cycloalkyl, amino or oxo; More preferably, R 1 and R 2 , R 1 and R 11 are linked to adjacent atoms to form a 5-7 membered heterocyclic group containing 1-3 atoms selected from N, O or S, optionally further C 3-6 Substituted by cycloalkyl or oxo; More preferably, R 1 and R 2 , R 1 and R 11 Linked with adjacent phenyl groups to form Optionally further halogen, C 1-3 Alkyl, C 1-3 Deuterated alkyl, C 3-6 is substituted by one or more substituents of cycloalkyl, amino or oxo; R 1 , R 2 , R 3 or R 11 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1- 6-deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, -NS(O)R a1 R b1 、-(CH2) n1 S(O)NR a2 R b2 、-P(O)R a3 R b3 or -NR a5 S(O)NR a4 R b4 , the amino group, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1- 6-Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, -NS(O)R a1 R b1 , C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R a1 , R b1 , R a2 , R b2 , R a3 , R b3 , R a4 or R b4 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl; Or, R a1 and R b1 , R a2 and R b2 , R a3 and R b3 , R a4 and R b4 They are linked to adjacent atoms to form C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, the C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 4 , R 5 or R 6 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3- 8-cycloalkyl, 3-8-membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R 7 , R 8 , R 9 or R 10 are each independently selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1- 6 alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl or -(CH2) m1 OR c1 , optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1- 6-Hydroxyalkyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6- 10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; R c1 is selected from hydrogen, deuterium, halogen, amino, nitro, hydroxyl, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1- 6 haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 aromatic or 5-10 membered heteroaryl, the amino, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Sulfanyl, C 1-6 Alkoxy, C 1-6 Halogenated alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 Aryl or 5-10 membered heteroaryl, optionally further substituted with halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 Alkyl, C 1-6 Deuterated alkyl, C 1-6 Haloalkyl, C 1-6 Hydroxyalkyl, C 1-6 Alkoxy, C 1- 6-haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 3-8 membered heterocyclic group, C 6-10 is substituted by one or more substituents of aryl or 5-10 membered heteroaryl; or, R 10 The atoms connected to it and the adjacent atoms link to form C 3-10 Cycloalkyl, 3-10 membered heterocyclic group, C 6-12 Aryl or 5-12 membered heteroaryl; n1 is an integer from 0 to 5; m1 is an integer ranging from 0 to 5.

12. The compound according to any one of claims 8 to 11, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof, wherein: The compound structure is as follows:

13. A compound represented by the general formula (IN-A), (IN-B) or (IN-C), a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: in, In the general formula (IN-A), R 13 Selected from C 3-8 Cycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl; the C 3-8 Cycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, optionally further deuterated, halogen, amino, nitro, hydroxy, cyano, oxo, C 1-6 One or more substituents in the alkyl group; Ring A, Ring B, L1, L2, R 3 , R 4 , R 5 , R 6 , R 9 The definition of as in claim 1; In the general formula (IN-B), ring D is selected from C 3-8 bicyclic cycloalkyl, 3-8 membered bicyclic heterocyclic group or 5-10 membered bicyclic heteroaryl containing 1-3 atoms selected from N, O or S; Ring C, Ring E, L3, R 1 , R7, R 8 , R 14 , R 15 , n is defined as in claim 1; In the general formula (IN-C), ring F is selected from a 8-14 membered tricyclic fused heterocyclic group containing 1-5 heteroatoms; ring B, L1, L2, R 1 , R 4 , R 5 , R 6 , R 9 , x is defined as in claim 8.

14. A method for preparing a compound of the general formula as claimed in claims 1 to 12, characterized in that: The following steps are included: Among them: Ring A, Ring B, Ring C, Ring D, Ring E, L1, L2, L3, R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 13 , R 14 , R 15 , R 16 The definition of as in claim 1; The general formula (IN-A) and the general formula (IN-B) react under the action of a condensing agent and a base to obtain the general formula (XIX); The condensing agent is selected from EDC, DIC, DCC, TBTU, HATU, HBTU, HCTU, DEPBT, PyBOP or PyAOP, preferably HATU; The base is selected from DIPEA, DIEA, Et3N, NMP, DBU or DABCO, preferably DIPEA; Or, including the following steps, Among them: Ring F, Ring B, Ring C, Ring E, L1, L2, L3, R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , R 13 , R 14 , the definition of x is as described in claim 8; The general formula (IN-C) and the general formula (IN-D) react under the action of a condensing agent and a base to obtain the general formula (XVI); The condensing agent is selected from EDC, DIC, DCC, TBTU, HATU, HBTU, HCTU, DEPBT, PyBOP or PyAOP, preferably HATU; The base is selected from DIPEA, DIEA, Et3N, NMP, DBU or DABCO, preferably DIEA.

15. A pharmaceutical composition comprising a therapeutically effective dose of a compound as claimed in any one of claims 1 to 12, a prodrug thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers or excipients.

16. Use of the compound according to any one of claims 1 to 12, its prodrug, its stereoisomer or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition according to claim 15 in the preparation of a GLP-1 receptor agonist drug.

17. Use of the compound according to any one of claims 1 to 12, its prodrug, its stereoisomer or its pharmaceutically acceptable salt, or the pharmaceutical composition according to claim 15 in the preparation of a medicament for treating metabolic-related diseases; the disease is selected from diabetes, obesity or non-alcoholic fatty liver disease-related diseases or other related diseases caused by diabetes, obesity or non-alcoholic fatty liver disease.