Lactam derivatives to inhibit NLRP3 and their uses.

Abstract

This description relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R3, R4, R4a, R4b, Z, R5, R6, R6', and R6'D are described herein, and R7 and R2 combine to form a 5- to 10-membered monocyclic or bicyclic heterocycle or a 5- to 10-membered monocyclic or bicyclic heteroaryl, and methods of preparation, methods of treatment and prevention, and pharmaceutical compositions comprising them. This description further relates to the use of the compounds of Formula (I) and pharmaceutically acceptable salts thereof in the treatment or prevention of diseases and disorders related to NLRP3.