Optimized cd3 antigen-binding domains.

Abstract

This application relates to antibodies or fragments thereof comprising an antigen-binding domain capable of binding to a CDS protein or a fragment thereof. This application also relates to such CDS-binding antibodies that have optimized affinity for inducing T-cell activation, but without being associated with excessive cytokine release and reduced tolerability. The application further relates to methods for producing these antibodies and their therapeutic uses.