Stereoisomers of compounds derived from benzo[b][1,5,4]oxathiazine and use for treating cancer.

Abstract

The stereoisomeric compounds of 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro(benzo)(b)(1,5,4)oxatiazecin-3,1'-cyclopropane)-2,2-dioxide and the pharmaceutical compositions comprising them are described. Methods of their use for the treatment, prevention, or improvement of a disease or disorder in which the RAS pathway is activated, such as cancer, RASopathies, and laminopathies, are also described.