Isoflavone carbamate compound, preparation method and applications of isoflavone carbamate compound
By developing new isoflavone carbamate compounds, we have solved the problems of single action and high side effects of existing drugs for treating Alzheimer's disease and vascular dementia, achieved selective inhibition of acetylcholinesterase and neuroprotection, and provided New possibilities for treating neurodegenerative diseases.
CN102827131AInactive Publication Date: 2012-12-19SICHUAN UNIV
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Patent Information
- Application Number
- CN201210329644.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2012-09-10
- Publication Date
- 2012-12-19
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Existing drugs for treating Alzheimer's disease and vascular dementia have problems such as single target, many toxic and side effects, poor long-term efficacy for patients, and lack of effective drugs to block the progression of the disease.
Method used
A new class of isoflavone carbamate compounds and their pharmaceutically acceptable salts have been developed. By interacting with acetylcholinesterase inhibitors, they can selectively inhibit acetylcholinesterase, protect neurons and improve brain function.
Benefits of technology
This compound shows significant acetylcholinesterase inhibitory activity and selectivity, can effectively protect PC12 cells from hydrogen peroxide-induced damage, and has potential therapeutic effects on neurodegenerative diseases.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a novel isoflavone carbamate compound (I) and a pharmaceutically acceptable salt of the isoflavone carbamate compound, and also discloses a preparation method of the compound and applications in the preparation of drugs for treating and / or preventing related neurodegenerative diseases, wherein the diseases include but not limit to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, human immunodeficiency virus (HIV) related dementia, multiple sclerosis, progressive lateral sclerosis, neuropathic pain, glaucoma and the like.
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