Method for improving the storage stability of a cosmetic preparation

Abstract

The present application aims to provide a method for stabilizing a cosmetic material for a long period. To achieve the above object, the present application provides a method for improving the storage stability of a cosmetic material, which comprises the step of incorporating a compound represented by the following general formula (1). (In formula (1), R 1 represents a group represented by general formula (2) or a hydrocarbon group having 2 or 3 carbon atoms.)(In formula (2), R 2 represents an alkylene group having 1 to 3 carbon atoms, and n represents a number 0 or 1.

Description

Technical Field

[0001] This invention relates to a method for improving the preservation stability of cosmetics. Background Technology

[0002] In cosmetics, antibacterial agents and preservatives are commonly used to inhibit the growth of bacteria and microorganisms. Parabens are the most frequently used antibacterial and preservative agents in cosmetics. While parabens have high antibacterial and preservative effects, they are also highly irritating to the skin, and their concentration in cosmetics is limited to less than 1% by weight in Japan. Therefore, the use of parabens is sometimes restricted. Furthermore, recently, the number of people experiencing allergic reactions to parabens has been increasing, leading to a surge in demand for cosmetics that do not contain parabens.

[0003] Therefore, antibacterial and preservative agents that can be used as substitutes for parabens in cosmetics include: alkyl diol compounds such as phenoxyethanol and 1,2-octanediol; glyceryl ether compounds such as 2-ethylhexylglycerin and n-hexylglycerin; etc. These compounds have antibacterial properties, are less irritating to the skin than parabens, and are safer for the human body. As a result, they have begun to be frequently used in pharmaceuticals and cosmetics in recent years (see, for example, patent documents 1-4).

[0004] However, when 1,2-octanediol, 2-ethylhexylglycerin ether, and n-hexylglycerin ether are incorporated into cosmetics, especially in cream-based formulations, their storage stability deteriorates, sometimes resulting in separation and precipitation. On the other hand, compared to these compounds, the presence of phenoxyethanol provides relative stability at room temperature (below 25°C), but under high-temperature conditions such as in summer, it may exhibit separation and precipitation similar to 1,2-octanediol, 2-ethylhexylglycerin ether, and n-hexylglycerin ether.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 10-265330

[0008] Patent Document 2: Japanese Patent Application Publication No. 2007-145748

[0009] Patent Document 3: Japanese Patent Application Publication No. 2015-086159

[0010] Patent Document 4: Japanese Patent Application Publication No. 2016-029099 Summary of the Invention

[0011] The problem that the invention aims to solve

[0012] As mentioned above, cosmetics, under various constraints, uniformly combine water-soluble and oil-soluble components, and as a product, they need to maintain this uniform state over a long period. Among compounds such as antibacterial preservatives, which can be used for purposes different from stabilizers, compounds with stabilizing effects in cosmetics have been discovered. Incorporating these compounds into cosmetics is useful in reducing the types and amounts of stabilizers and other additives used.

[0013] Solution for solving the problem

[0014] Therefore, the inventors conducted in-depth research and discovered that the compound represented by the following general formula (1), which has antibacterial and preservative properties, helps to improve the preservation stability of cosmetics, thus completing the present invention. That is, the present invention is a method for improving the preservation stability of cosmetics, comprising the step of using a compound represented by the following general formula (1).

[0015]

[0016] (where R is in the formula) 1 This refers to the group represented by general formula (2) or a hydrocarbon group with 2 or 3 carbon atoms.

[0017]

[0018] (where R is in the formula) 2 (This indicates an alkylene group with 1 to 3 carbon atoms, where n represents the number 0 or 1.)

[0019] Invention Effects

[0020] In this invention, compounds of general formula (1), known for their antibacterial and preservative effects, can be used to improve the stability of cosmetics, thus reducing the types and amounts of stabilizers and other additives required. Furthermore, the use of this compound prevents separation and precipitation of cosmetics even in hot and humid summer conditions. In particular, cosmetics containing antibacterial and preservative agents such as phenoxyethanol, 1,2-octanediol, 2-ethylhexylglycerin ether, or n-hexylglycerin ether sometimes exhibit decreased stability; this invention also helps stabilize cosmetics containing any of these agents.

[0021] Furthermore, the compounds represented by general formula (1) have low skin irritation, and thus, cosmetics with low skin irritation can also be provided by applying the present invention. Detailed Implementation

[0022] The present invention is a method for improving the preservation stability of cosmetics. Specifically, the method for improving the preservation stability of cosmetics includes the step of using a compound represented by the following general formula (1).

[0023]

[0024] (where R is in the formula) 1 This refers to the group represented by general formula (2) or a hydrocarbon group with 2 or 3 carbon atoms.

[0025]

[0026] (where R is in the formula) 2 (This indicates an alkylene group with 1 to 3 carbon atoms, where n represents the number 0 or 1.)

[0027] In general formula (1), R 1 The group represented by general formula (2) or a hydrocarbon group having 2 or 3 carbon atoms. Examples of hydrocarbon groups having 2 or 3 carbon atoms include ethyl, propyl, and isopropyl, among which ethyl is preferred from the viewpoint of easily obtaining the effects of the present invention.

[0028] In general formula (2), R 2 The group refers to an alkylene group having 1 to 3 carbon atoms. Examples of such groups include methylene, ethylene, propylene, and isopropylene. Among these, methylene and ethylene are preferred from the viewpoint of easy availability and ease of use as raw materials.

[0029] n represents the number 0 or 1, and from the viewpoint of obtaining a compound that readily yields the effects of the present invention, n is preferably 0.

[0030] In compounds represented by such general formula (1), especially from the viewpoint that cosmetics with high storage stability, excellent antibacterial and preservative effects, and low skin irritation can be easily obtained through the present invention, R of general formula (1) is preferred. 1 Compounds of the group represented by general formula (2).

[0031] For compounds of general formula (1), compounds of general formula (1) can be manufactured directly, or commercially available products can be purchased.

[0032] The method of manufacturing the compound shown in general formula (1) is not particularly limited. Any known manufacturing method can be used.

[0033] Among them, R in the compound represented by general formula (1) 1 In the case of a hydrocarbon group having 2 or 3 carbon atoms, it is convenient to manufacture or purchase a commercially available product by any of the manufacturing methods i or ii described below, and therefore preferred.

[0034] Manufacturing method i

[0035] A method for producing 1,2-diol by reacting hydrogen peroxide with olefins in the presence of a catalyst.

[0036] Manufacturing Method ii

[0037] A method for producing 1,2-diols from olefins via epoxides in the presence of an oxidizing agent.

[0038] Of the manufacturing methods i and ii described above, and of purchasing commercially available products, purchasing commercially available products is preferred from a simpler point of view. Examples of commercially available products include those manufactured by Osaka Organic Chemical Industry Co., Ltd., Tokyo Chemical Industry Co., Ltd., and Advanced Alcohol Industry Co., Ltd.

[0039] Additionally, R in the compound represented by general formula (1) 1 When the group is represented by the general formula (2), it is simple and inexpensive to manufacture by any of the manufacturing methods I to VI described below, and therefore preferred.

[0040] Manufacturing Method I

[0041] A method for causing an alcohol compound represented by the following general formula (3) to undergo a dehydration condensation reaction with glycerol.

[0042]

[0043] (where R is in the formula) 3 (This indicates an alkylene group with 1 to 3 carbon atoms; m represents the number 0 or 1.)

[0044] Manufacturing Method II

[0045] A method for reacting the alcohol compound represented by the above general formula (3) with 1-chloro-2,3-propanediol to undergo a dehydrochlorination reaction.

[0046] Manufacturing Method III

[0047] A method for hydrolyzing the resulting glycidyl ether compound after reacting the alcohol compound represented by general formula (3) with epichlorohydrin.

[0048] Manufacturing Method IV

[0049] A method for reacting the alcohol compound represented by general formula (3) with glycidyl ether.

[0050] Manufacturing method V

[0051] A method for hydrolyzing the resulting glycidyl ether compound by reacting the alcohol compound represented by general formula (3) with allyl chloride or allyl bromide and then oxidizing it with hydrogen peroxide or the like.

[0052] Manufacturing Method VI

[0053] A method for reacting the compound represented by the following general formula (4) with glycerol to undergo dehydrohalogenation.

[0054]

[0055] (where R is in the formula) 4 (This indicates an alkylene group with 1 to 3 carbon atoms, where q represents the number 0 or 1, and X represents a halogen atom.)

[0056] Of the methods described above, from the viewpoint of being simpler and cheaper, it is more preferable to manufacture by method III.

[0057] In general formula (3), R 3 Indicates an alkylene group having 1 to 3 carbon atoms. As R 3 Examples of suitable materials include methylene, ethylene, propylene, and isopropylene. From the viewpoint of easy availability and manufacture of raw materials, methylene and ethylene are preferred. m represents the number 0 or 1; from the viewpoint of obtaining compounds that readily achieve the effects of the present invention, m is preferably 0.

[0058] In general formula (4), R 4 Indicates an alkylene group having 1 to 3 carbon atoms. As R 4 Examples of suitable materials include methylene, ethylene, propylene, and isopropylene. From the viewpoint of easy availability and manufacture of raw materials, methylene and ethylene are preferred. q represents the number 0 or 1; from the viewpoint of obtaining compounds that readily achieve the effects of the present invention, q is preferably 0.

[0059] The amount of the compound represented by general formula (1) is not particularly limited, but from the viewpoint of easily obtaining the effects of the present invention, it is preferable to use it at 0.05 to 5% by mass in the total amount of cosmetics, more preferably at 0.1 to 3% by mass, and even more preferably at 0.5 to 1% by mass.

[0060] The compound shown in general formula (1) has antibacterial and preservative properties, low skin irritation, and high safety for the human body. Therefore, it can be used as an antibacterial and preservative ingredient in the same way as antibacterial and preservative agents for cosmetics. By being incorporated into cosmetics, it can impart antibacterial and preservative properties to cosmetics.

[0061] Furthermore, compared to commonly used antibacterial preservatives for cosmetics, it exhibits very good preservation stability when incorporated into cosmetics, and therefore can also be used as a preservation stability improver for cosmetics. It should be noted that this preservation stability is not only effective at room temperature (below 25°C), but also under assumed high-temperature conditions in summer (40–60°C).

[0062] The compound represented by general formula (1) can be used together with commonly used antimicrobial preservatives for cosmetics as an antimicrobial preservative ingredient. When commonly used antimicrobial preservatives for cosmetics are used alone as an antimicrobial preservative ingredient in cosmetics, the shelf life of the cosmetics may sometimes deteriorate significantly. However, by using it in combination with the compound represented by general formula (1), this deterioration in shelf life can be suppressed. It should be noted that this shelf life stability is maintained not only at room temperature (below 25°C) but also under assumed high-temperature conditions (40–60°C) during summer.

[0063] Commonly used antibacterial and preservative agents in cosmetics include, for example, benzoic acid, salicylic acid, carbolic acid, sorbic acid, potassium sorbate, parabens, sodium benzoate, p-chloro-m-cresol, hexachlorophenol, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizers, chlorphenesin, phenoxyethanol, n-hexylglycerol ether, methylparaben, ethylparaben, butylparaben, octylethylene glycol, 2-ethylhexylglycerol ether, resorcinol, triclosan, isopropyl methylphenol (IPMP), bis(2-thio-1-pyridine oxide) zinc, alkyl diaminoethyl glycine hydrochloride, pyridone ethanolamine salt, physalicylic acid, vitamin B6 hydrochloride (pyridoxine hydrochloride), phenol, chlorinated lysozyme, and cetylpyridinium chloride (CPC). Among them, the compound used in combination with the compound shown in general formula (1) is preferably selected from one or more of the group consisting of phenoxyethanol, n-hexylglycerol ether, octyl glycol, and ethylhexylglycerol, and is particularly preferably selected from one or two of the group consisting of n-hexylglycerol ether and ethylhexylglycerol, from the viewpoint of low skin irritation, high safety to the human body, and significant effect of the present invention.

[0064] From the viewpoint of antibacterial and preservative properties, the use of such an antibacterial preservative in the present invention inhibits the deterioration of preservation stability and easily yields a cosmetic with good preservation stability and high antibacterial and preservative effects, which is therefore preferred.

[0065] When the compound of general formula (1) is used together with an antibacterial preservative in a cosmetic, the ratio of the compound of general formula (1) to the antibacterial preservative in the cosmetic is not particularly limited as long as the effect of the present invention can be obtained. However, from the viewpoint of particularly improving the preservation stability of the cosmetic and easily obtaining a cosmetic with high antibacterial and preservative effects, it is preferable to set the mass ratio to 10:1 to 1:10, more preferably to 1:5 to 5:1, and even more preferably to 1:3 to 3:1.

[0066] When the compound represented by general formula (1) is incorporated into a cosmetic, the method of incorporation is not limited. It can be incorporated by dissolving it together with other aqueous components during the cosmetic manufacturing stage. Even if the cosmetic is manufactured in advance with components other than the compound represented by general formula (1), the effects of the present invention will be fully realized.

[0067] The dosage form of the cosmetics referred to in this specification is not particularly limited. For example, liquid, gel, sherbet, lotion, cream, ointment, solid paste, paste, solid, powder, etc., can be listed. Among them, by applying the present invention to cream-type cosmetics, which are prone to poor shelf-life stability when formulated with commonly used cosmetic antibacterial preservatives, cosmetics with significantly high shelf-life stability can be obtained, and therefore are preferred. Here, "cream" refers to a turbid, non-flowing, viscous form.

[0068] Furthermore, examples of cream-based cosmetics include oil-free creams (containing no oil), water-free creams (containing no water), oily creams with high oil content, mildly oily creams with low oil content, and medium-oily creams with oil content between oily and mildly oily creams. From the viewpoint of achieving the effects of the present invention more significantly, cosmetics targeting oily creams, mildly oily creams, and medium-oily creams are preferred. Additionally, in the case of emulsions such as oily creams, mildly oily creams, and medium-oily creams, which disperse two immiscible liquids such as water and oil in a stable state, they are generally classified into two types: oil-in-water (O / W) type, where water serves as a continuous layer to disperse the oil-soluble components, and water-in-oil (W / O) type, where oil serves as a continuous layer to disperse the water-soluble components. However, in any case, as long as the cream has a good balance of oil and water, the effects of the present invention can be easily obtained. Therefore, it is preferred, specifically, to use a cosmetic cream with a balanced oil content of 20-80% by mass and a water content of 80-20% by mass. It is particularly preferred to use a cosmetic cream with a balanced oil content of 20-40% by mass and a water content of 80-60% by mass.

[0069] From the viewpoint that the effects of the present invention can be easily obtained and that dosage forms such as liquid, gel, cream, lotion, cream, ointment, solid paste, paste, solid, and powder can be easily maintained, cosmetics using the method of the present invention preferably contain at least one selected from the group consisting of surfactants and higher alcohols.

[0070] As surfactants, examples include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants. Examples of nonionic surfactants include: sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglyceryl sorbitan penta-2-ethylhexanoate, diglyceryl sorbitan tetra-2-ethylhexanoate, etc.); glycerol fatty acid esters / polyglycerol fatty acid esters (e.g., glycerol monocotyledonate, glycerol monoerucic acid ester, glycerol monoerucic acid ester, glycerol sesquioleate, glycerol monostearate, glycerol α,α'-oleic acid pyroglutamate, glycerol monostearate malate). Polyglycerol fatty acid esters (e.g., polyglycerol laurate, polyglycerol myristate, polyglycerol palmitate, polyglycerol stearate, polyglycerol polyricinoleate); propylene glycol fatty acid esters (e.g., propylene glycol monostearate); hydrogenated castor oil derivatives; glyceryl alkyl ethers; POE-sorbitan fatty acid esters (e.g., POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.). ); POE-sorbitol fatty acid esters (e.g., POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerol fatty acid esters (e.g., POE-glycerol monostearate, POE-glycerol monoisostearate, POE-glycerol triisostearate, POE-monoleate, etc.); POE-fatty acid esters (e.g., POE-distearate, POE-monostearate, P... OE – mono-dioleate, ethylene glycol distearate, etc.; POE – alkyl ethers (e.g., POE – lauryl ether, POE – oleyl ether, POE – stearyl ether, POE – benzyl ether, POE – 2-octyl dodecyl ether, POE – cholesterol ether, etc.); Pluronic type (e.g., Pluronic, etc.); POE / POP – alkyl ethers (e.g., POE / POP – cetyl ether, POE / POP – 2-decyl tetradecyl ether, POE / PO P-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glyceryl ether, etc.; tetra-POE / tetra-POP-ethylenediamine condensates (e.g., Tetronic, etc.); POE-caster oil hydrogenated castor oil derivatives (e.g., POE-caster oil, POE-hydrogenated castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, POE-hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE-hydrogenated castor oil maleic acid, etc.);POE – beeswax / lanolin derivatives (e.g., POE – sorbitol beeswax); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE – propylene glycol fatty acid esters; POE – alkylamines; POE – fatty acid amides; sucrose fatty acid esters; alkylethoxydimethylamine oxide; trioleoyl phosphate; etc.

[0071] Examples of anionic surfactants include: fatty acid soaps (e.g., sodium lauryl sulfate, sodium palmitate, etc.); higher alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); N-acylsarcosine (e.g., sodium lauroylsarcosine, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl taurate, sodium lauryl methyl taurate, etc.); phosphates (POE-oil-based ether phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, etc.). Sodium lauryl polypropylene glycol sulfosuccinate, etc.; alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfates (e.g., sodium hydrogenated coconut oil fatty acid glycerol sulfate, etc.); N-acylglutamates (e.g., N-lauroyl glutamate monosodium, N-stearoyl glutamate disodium, N-myristoyl-L-glutamate monosodium, etc.); sulfated oils (e.g., Taikoo oil, etc.); POE-alkyl ether carboxylic acids; POE-alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkanolamide sulfates; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid di-triethanolamine; sodium casein; etc.

[0072] Examples of cationic surfactants include: alkyl trimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkyl pyridinium salts (e.g., cetylpyridinium chloride, etc.); distearate dimethylammonium chloride; dialkyl dimethylammonium salts; chlorinated poly(N,N'-dimethyl-3,5-methylenepiperidinium); alkyl quaternary ammonium salts; alkyl dimethylbenzylammonium salts; alkyl isoquinolineium salts; dialkyl morpholineium salts; POE-alkylamines; alkylamine salts; polyamine fatty acid derivatives; pentanol fatty acid derivatives. ; benzalkonium chloride; benzyl chloride; etc., as amphoteric surfactants, for example, include: imidazoline amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium salt, 2-cocoyl-2-imidazolineonium hydroxide-1-carboxyethoxy2 sodium salt, etc.); betaine surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolineonium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amide betaine, sulfobetaine, etc.); etc.

[0073] One or more of the above-mentioned same / different surfactants may be used.

[0074] In this invention, cream-form cosmetics are preferred. Therefore, nonionic surfactants are preferred in this invention, and one or more selected from glycerol fatty acid esters / polyglycerol fatty acid esters and POE-fatty acid esters are more preferred.

[0075] The amount of surfactant used is not particularly limited, but from the viewpoint of easily obtaining the effects of the present invention, it is preferable to use 0.5 to 30% by mass in the total amount of cosmetics, more preferably 1 to 15% by mass, and even more preferably 2 to 8% by mass.

[0076] As higher alcohols, examples include monohydric alcohols having a hydrocarbon group (straight-chain or branched, saturated or unsaturated) with 8 to 30 carbon atoms. More specifically, examples include, for instance, caprylyl alcohol, capryl alcohol, lauryl alcohol, myristol, cetyl alcohol, hexyldecyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, octyldodecyl alcohol, squalene, decyltetraol, hexyldecyl alcohol, eicosyl alcohol, betaine alcohol, carnaubyl alcohol, wax alcohol, etc., and one or more of these can be used. Among these, from the viewpoint of making a cosmetic cream in which the effects of the present invention are readily obtained, it is preferable to use one or more of cetyl alcohol, stearyl alcohol, eicosyl alcohol, and betaine alcohol, and more preferably betaine alcohol.

[0077] The amount of higher alcohols is not particularly limited, but from the viewpoint of easily obtaining the effects of the present invention, it is preferable to use 0.5 to 30% by mass in the total amount of cosmetics, more preferably 1 to 15% by mass, and even more preferably 2 to 8% by mass.

[0078] For the method of the present invention, as long as it is a cosmetic material, the effects of the present invention can be obtained in any application. However, from the viewpoint of obtaining more significant effects of the present invention, cosmetic materials used for washing face, removing makeup, and massaging, such as cold cream, nourishing cream, night cream, hand cream, body cream, and shaving cream, are preferred.

[0079] In cosmetics using the method of the present invention, any ingredient commonly used as an additive in cosmetics can be incorporated. Examples of such ingredients include solvents, powder components, oils, waxes, silicone oils, ester oils, hydrocarbon oils, higher fatty acids, moisturizers, water-soluble polymers, multivalent chelating agents, sugars, amino acids and their derivatives, organic amines, pH adjusters, vitamins, antioxidants, ultraviolet absorbers, fragrances, beauty ingredients, blood circulation promoters, anti-inflammatory agents, revitalizing agents, anti-seborrheic agents, anti-inflammatory agents, and various other extracts; one or more of these ingredients can be incorporated in combination.

[0080] Examples of solvents include alcohols such as ethanol, propanol, isopropanol, butanol, propylene glycol, dipropylene glycol, butanediol, and glycerol.

[0081] As powder components, examples include: inorganic powders (e.g., talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, silicon dioxide, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powders, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powders ( Examples include polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.; inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red lead), iron titanate, etc.); inorganic brown pigments (e.g., γ-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, loess, etc.); inorganic black pigments (e.g., black iron oxide, low-dimensional...). Inorganic pigments include: titanium dioxide, etc.; inorganic purple pigments (e.g., manganese violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, dark blue, etc.); pearlescent pigments (e.g., titanium dioxide coated mica, titanium dioxide coated bismuth oxychloride, titanium dioxide coated talc, colored titanium dioxide coated mica, bismuth oxychloride, fish scale foil, etc.); metallic powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lake (e.g., Red 201, Red 202, Red 204, Red 20...). Organic pigments such as No. 5, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404; Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, and Blue 1; natural pigments (e.g., chlorophyll, β-carotene); etc.

[0082] Examples of oils and fats include, for example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, almond oil, wheat germ oil, camellia oil, castor oil, flaxseed oil, safflower oil, cottonseed oil, perilla seed oil, soybean oil, peanut oil, tea seed oil, torreya nut oil, rice bran oil, Chinese tung oil (Paulownia mikado oil), Japanese tung oil (Paulownia tomentosa oil), jojoba oil, wheat germ oil, triglycerides, cocoa butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, sumac kernel oil, hydrogenated oil, wood wax, hydrogenated castor oil, rosemary oil, chamomile oil, eucalyptus oil, rice germ oil, wheat germ oil, gamma-oryzanol, phytoceramides (glycosylceramides), and carrot oil. Oils include: Coix seed extract, horsetail extract, arnica extract, chamomile extract, lithospermum root extract, linden extract, yarrow extract, sage extract, angelica extract, horse chestnut extract, peach leaf extract, rosemary extract, coix seed extract, loquat extract, borage oil, evening primrose oil, etc.

[0083] Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, insect wax, whale wax, lignite wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl ester, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

[0084] Examples of silicone oils include: chain silicone oils such as polydimethylsiloxane, methyl polytrimethylsiloxane, and octyl polymethylsiloxane; cyclic silicone oils such as octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane; phenyl silicone oils such as diphenyl polydimethylsiloxane, diphenylpropyl polydimethylsiloxane, phenyl polytrimethylsiloxane, trimethylpentaphenyltrisiloxane, diphenylsiloxyphenyl polytrimethylsiloxane, and trimethylsiloxyphenyl polydimethylsiloxane; etc.

[0085] Examples of ester oils include isopropyl myristate, octyl dodecyl myristate, isopropyl palmitate, hexyldecyl dimethyloctoate, isocetyl stearate, diisobutyl adipate, tri-2-ethylhexanoate, trimethylolpropane triisostearate, trimyristate, trioctyl glycerol, triisopalmitoate, cetyl ethylhexanoate, and 2-ethylhexyl palmitate.

[0086] Examples of hydrocarbon oils include liquid paraffin, ceresin, squalane, pterostilbene, paraffin wax, pure ceresin, squalene, petrolatum, and microcrystalline wax.

[0087] Examples of high-grade fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, benzolic acid, oleic acid, undecenoic acid, tall oil fatty acids, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0088] Examples of moisturizers include polyethylene glycol, erythritol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucin sulfate, carboxylic acid, determinate collagen, cholesterol-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglyceride (EO)PO adduct, prickly pear extract, yarrow extract, and mesona chinensis extract.

[0089] Examples of water-soluble polymers include: starch-based polymers (e.g., carboxymethyl starch, methyl hydroxypropyl starch, etc.); cellulose-based polymers (methylcellulose, ethylcellulose, methyl hydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginate-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.); vinyl-based polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymers, etc.); polyoxyethylene-based polymers (e.g., polyoxyethylene-polyoxypropylene copolymers obtained from polyethylene glycol 20000, 40000, or 60000, etc.); acrylic polymers (e.g., sodium polyacrylate, ethyl polyacrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers; etc.

[0090] Examples of multivalent chelating agents include, for example, 1-hydroxyethane-1,1-diphosphonic acid, tetrasodium 1-hydroxyethane-1,1-diphosphonic acid, disodium ethylenediaminetetraacetate, trisodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid, and trisodium hydroxyethylethylenediaminetriacetate.

[0091] As monosaccharides, examples include: trioses (e.g., D-glyceraldehyde, dihydroxyacetone, etc.); tetraoses (e.g., D-erythrose, D-erythritol, D-threose, etc.); pentoses (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc.); hexoses (e.g., D-glucose, D-tarose, D-alulose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); heptoses (… Examples include aldoheptose and heptulose; octose (e.g., octulose); deoxyglucose (e.g., 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose); aminoglucosides (e.g., D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid); uronic acids (e.g., D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid, L-iduronic acid); etc.

[0092] Examples of oligosaccharides include sucrose, umbelliferous sugar, lactose, planteose, isocorhizose, α,α-trehalose, raffinose, succinose, umbilicin, stachyose, and verbascose.

[0093] Examples of polysaccharides include cellulose, quince seeds, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratin sulfate, chondroitin, xanthan gum, mucin sulfate, guar gum, dextran, keratin sulfate, locust bean gum, succinyl polysaccharide, carnosic acid, etc.

[0094] Examples of amino acids include, for example, neutral amino acids (e.g., threonine, cysteine, etc.); basic amino acids (e.g., hydroxylysine, etc.); etc. Additionally, examples of amino acid derivatives include, for example, sodium lauroyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0095] Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0096] As pH adjusters, examples include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.

[0097] Examples of vitamins include, but are not limited to, vitamin E and its derivatives, vitamin C and its derivatives, vitamin D and its derivatives, vitamin F and its derivatives, vitamin K and its derivatives, vitamin A and its derivatives, and vitamin B derivatives. Specifically, examples include γ-tocopherol, stearate ascorbate, dipalmitate ascorbate, tocopheryl nicotinate, menadione, dehydrocholesterol, ergocalciferol, pyridoxine dioctanoate, ascorbyl tetra-hexyldecanoate (VCIP), retinol, retinyl palmitate, retinyl acetate and other retinol derivatives, docosahexaenoic acid, linoleic acid, panthenol, tocopheryl linoleate, isopropyl linoleate, linolenic acid, pyridoxine palmitate, vitamin A, β-carotene, pyridoxine dipalmitate, phylloquinone, pantothenic acid and its derivatives, and biotin.

[0098] As antioxidants, examples include butylated hydroxytoluene, butylated hydroxyanisole, sorbic acid, sodium sulfite, sodium bisulfite, sodium thiosulfate, metabisulfite, thiotaurine, taurine, thioglycerol, thiourea, mercaptoacetic acid, cysteine ​​hydrochloride, propyl gallate, gallic acid derivatives, ascorbic acid, ascorbic acid derivatives (ascorbic acid phosphate, etc.), tocopherol, tocopherol derivatives, isoascorbic acid, p-tert-butylphenol, phytic acid, L-cysteine ​​hydrochloride, etc.

[0099] Examples of UV absorbers include benzoic acid-based UV absorbers, anthranilic acid-based UV absorbers, salicylic acid-based UV absorbers, cinnamic acid-based UV absorbers, benzophenone-based UV absorbers, benzotriazole-based UV absorbers, triazine-based UV absorbers, benzoate-based UV absorbers, cyanoacrylate-based UV absorbers, oxaloyl aniline-based UV absorbers, and formamidin-based UV absorbers. Examples of benzoic acid-based ultraviolet absorbers include, for example, p-aminobenzoic acid, ethyl p-aminobenzoate, ethylhexyl p-dimethylaminobenzoate, octyl p-dimethylaminobenzoate, pentyl p-dimethylaminobenzoate, glyceryl mono-p-aminobenzoate, glyceryl p-aminobenzoate, ethyl dihydroxypropyl p-aminobenzoate, ethyl N,N-dipropoxy p-aminobenzoate, ethyl N,N-diethoxy p-aminobenzoate, ethyl N,N-dimethyl p-aminobenzoate, butyl N,N-dimethyl p-aminobenzoate, pentyl N,N-dimethyl p-aminobenzoate, octyl N,N-dimethyl p-aminobenzoate, and hexyl diethylaminohydroxybenzoylbenzoate. Examples of anthranilic acid-based ultraviolet absorbers include, for example, menthol ester N-acetyl anthranilic acid.

[0100] Examples of salicylic acid-based ultraviolet absorbers include, for example, salicylic acid and its sodium salt, pentyl salicylate, menthyl salicylate, menthol salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate. Examples of cinnamic acid-based ultraviolet absorbers include, for example, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isopentyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (2-ethylhexyl p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (Sinoxamate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate (octocrylene), glyceryl mono-2-ethylhexanoyl-di-p-methoxycinnamate, ferulic acid and its derivatives.

[0101] Examples of benzophenone-based ultraviolet absorbers include 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (benzophenone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylic acid ester, 2-hydroxy-4-n-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, and 5,5'-methylenebis(2-hydroxy-4-methoxybenzophenone).

[0102] Examples of benzotriazole-based ultraviolet absorbers include, for example, 2-(2-hydroxy-5-methylphenyl)benzotriazole, 2-(2-hydroxy-5-methylphenyl)-5-chlorobenzotriazole, 2-(2-hydroxy-5-tert-octylphenyl)benzotriazole, 2-(2-hydroxy-5-tert-octylphenyl)-5-chlorobenzotriazole, 2-(2-hydroxy-3,5-di-tert-butylphenyl)benzotriazole, 2-(2-hydroxy-3,5-di-tert-butylphenyl)-5-chlorobenzotriazole, 2-(2-hydroxy-3-tert-butyl-5-methylphenyl)benzotriazole, 2-(2-hydroxy-3-tert-butyl-5-methylphenyl)-5-chlorobenzotriazole, 2-(2-hydroxy-3,5-dicumylphenyl)benzotriazole, 2-(2-hydroxy-3,5-dicumylphenyl)-5-chloro ...2'-Methylenebis(4-tert-octyl-6-benzotriazolylphenol), polyethylene glycol esters of 2-(2-hydroxy-3-tert-butyl-5-carboxyphenyl)benzotriazole, 2-[2-hydroxy-3-(2-acryloyloxyethyl)-5-methylphenyl]benzotriazole, 2-[2-hydroxy-3-(2-acryloyloxyethyl)-5-methylphenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-(2-methacryloyloxyethyl)-5-tert-butylphenyl]benzotriazole, 2-[2-hydroxy-3-(2-methacryloyloxyethyl)-5-tert-butylphenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3- (2-Methacryloxyethyl)-5-tert-octylphenyl]benzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)-5-tert-octylphenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)-5-tert-butylphenyl]benzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)-5-tert-butylphenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-5-(2-methacryloxyethyl)phenyl]benzotriazole, 2-[2-hydroxy-5-(2-methacryloxyethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-(2-methacryloxyethyl)phenyl]-5-chlorobenzotriazole, [2-[2-hydroxy-3-tert-butyl-5-(2-methacryloyloxyethyl)phenyl]benzotriazole, 2-[2-hydroxy-3-tert-butyl-5-(2-methacryloyloxyethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-tert-pentyl-5-(2-methacryloyloxyethyl)phenyl]benzotriazole, 2-[2-hydroxy-3-tert-pentyl-5-(2-methacryloyloxyethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-3-tert-butyl-5-(3-methacryloyloxypropyl)phenyl] ... 2-[2-hydroxy-4-(2-methacryloyloxymethyl)phenyl]benzotriazole, 2-[2-hydroxy-4-(2-methacryloyloxymethyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-4-(3-methacryloyloxy-2-hydroxypropyl)phenyl]benzotriazole, 2-[2-hydroxy-4-(3-methacryloyloxy-2-hydroxypropyl)phenyl]-5-chlorobenzotriazole, 2-[2-hydroxy-4-(3-methacryloyloxypropyl)phenyl]benzotriazole, 2-[2-hydroxy-4-(3-methacryloyloxypropyl)phenyl]-5-chlorobenzotriazole, etc.

[0103] Examples of triazine-based ultraviolet absorbers include, for instance, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2-(2-hydroxy-4-methoxyphenyl)-4,6-diphenyl-1,3,5-triazine, 2-(2-hydroxy-4-hexyloxyphenyl)-4,6-diphenyl-1,3,5-triazine, 2-(2-hydroxy-4-hexyloxyphenyl)-4,6-diphenyl-1,3,5-triazine, 2-(2-hydroxy-4-octyloxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, and 2-[2-hydroxy-4-( [3-C12-C13 mixed alkoxy-2-hydroxypropoxy)phenyl]-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, 2-[2-hydroxy-4-(2-acryloyloxyethoxy)phenyl]-4,6-bis(4-methylphenyl)-1,3,5-triazine, 2-[2-hydroxy-4-(2-acetoxyethoxy)phenyl]-4,6-bisphenyl-1,3,5-triazine, 2-(2,4-dihydroxy-3-allylphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, 2,4,6-tris(2-hydroxy-3-methyl-4-hexyloxyphenyl)-1,3,5-triazine, etc. Examples of benzoic acid ester-based ultraviolet absorbers include resorcinol monobenzoate, 2,4-di-tert-butylphenyl-3,5-di-tert-butyl-4-hydroxybenzoate, octyl(3,5-di-tert-butyl-4-hydroxy)benzoate, dodecyl(3,5-di-tert-butyl-4-hydroxy)benzoate, tetradecyl(3,5-di-tert-butyl-4-hydroxy)benzoate, hexadecyl(3,5-di-tert-butyl-4-hydroxy)benzoate, octadecyl(3,5-di-tert-butyl-4-hydroxy)benzoate, betaine(3,5-di-tert-butyl-4-hydroxy)benzoate, stearyl(3,5-di-tert-butyl-4-hydroxy)benzoate, etc.

[0104] Examples of cyanoacrylate-based ultraviolet absorbers include, for example, ethyl-α-cyano-β,β-diphenyl acrylate and methyl-2-cyano-3-methyl-3-(p-methoxyphenyl)acrylate. Examples of oxaloylteaniline-based ultraviolet absorbers include, for example, 2-ethyl-2'-ethoxyoxaloylteaniline and 2-ethoxy-4'-dodecyloxaloylteaniline. Examples of formamidinium-based ultraviolet absorbers include N,N'-diphenyl-N'-(4-ethoxycarbonylphenyl)formamidinium, N'-(4-ethoxycarbonylphenyl)-N-methyl-N-phenylformamidinium, N,N'-bis(4-ethoxycarbonylphenyl)-N-methylformamidinium, N'-(4-ethoxycarbonylphenyl)-N-(2'-methoxyphenyl)-N-methylformamidinium, and N-(4-n-butoxycarbonylphenyl)-N'-(4'-ethylcarbonyl)-N-methylformamidinium.

[0105] Other ultraviolet absorbers include, for example, 3-(4'-methylbenzylene)-d,l-camphor, 3-benzylene-d,l-camphor, 2-phenyl-5-methylbenzoxazole, dibenzalazine, dianisoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentane-2-one, 4-tert-butylmethoxydibenzoylmethane, octyltriazinone, uric acid, ethyl uric acid, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzyldioxazolidinyl propionate, phenylbenzimidazole sulfonic acid, terephthalimethylene dicamphor sulfonic acid, cresoltrazolium trisiloxane, methyl anthranilate, rutin, rutin derivatives, oryzanol, and oryzanol derivatives.

[0106] As a flavoring, for example, blended flavorings that include natural and / or synthetic flavorings can be listed. Specifically, as natural fragrances, the following can be listed: jasmine oil, ambrette seed oil, ylang-ylang oil, ylang-ylang absolute, iris resinoid, iris absolute, iris oil, wintergreen oil, tarragon oil, elemi oleoresin, elemi resinoid absolute, elemi tincture, oakmoss concrete, oakmoss absolute, oakmoss resin, oakmoss resinoid, devilwood absolute, devilwood concrete, opopanax resinoid, opopanax absolute, opopanax oil, frankincense resinoid, frankincense absolute. Absolute), frankincense oil, allspice oil, oregano oil, oregano oleoresin, orange flower absolute, orange flower concrete, cananga oil, gurjun balsam, gurjun balsam oil, cassie absolute, cassie flower oil, cinnamon oil, cape jasmine absolute, carnation absolute, Brazilian sandalwood oil, chamomile oil, cardamom oil, galbanum oil, galbanum resin, galbanum resinoid, artemisia oil, carrot seed oil, litsea cubeba oil, guaiac wood oil, guaiac resin, guaiac concrete, camphor oil. oil), cumin oil, cumin absolute oil, cumin oleoresin (cumin)Oleoresin, sage oil, grapefruit oil, clove oil, costus oil, copaiba balsam, copaiba balsam oil, copaiba balsam resin, coriander oil, sandalwood oil, sage oil, cedar wood oil, lemongrass oil, jasmine oil, jasmine absolute, jasmine concrete, juniper berry oil, genet absolute, jonquil absolute, ginger oil, cinnamon oil, cinnamon bark oil, cinnamon leaf oil, Japanese cedar oil, star anise oil, styrax oil, styrax resinoid, lavender oil, spearmint oil, savory oil Oils including sage oil, cedar oil, cedar leaf oil, geranium oil, celery seed oil, thyme oil, marigold oil, orange oil, tuberose absolute, tea tree oil, tree moss absolute, tonka bean oil, tolu balsam, nutmeg oil, narcissus absolute, neroli oil, violet leaf absolute, pine oil, pine needle oil, basil oil, parsley leaf oil, parsley seed oil, parsley stem oil, patchouli oil, peppermint oil, vanilla absolute, honeysuckle absolute, palmarosa oil, valerian oil, bitter orange oil, hysso oil, and Japanese cypress oil. oils), Japanese cypress oil, hyacinth absolute, fennel oil, fig absolute, orange leaf oil, broom leaf oil, bay leaf oil, vetiver oil, pepper oil, peppermint absolute, peppermint oil, bergamot oil, Peru balsam, benzoin tincture, benzoin resin.(The following are listed as oils and their components: resinoid, linalool oil, marjoram oil, mandarin oil, satsuma oil, mimosa concrete, mimosa absolute, mimosa oil, stag seaweed resinoid, stag seaweed absolute, stag seaweed oil, musk absolute, musk tincture, eucalyptus oil, grapefruit oil, pearberry oil, labdanum resinoid, lavender oil, lavender absolute, lavender burnatii oil, lavender burnatii absolute, lemon oil, lemongrass oil, rose oil, rose absolute, rose concrete, rosemary oil, laurel oil, laurel leaf oil, etc.)

[0107] In addition, synthetic fragrances include asterolone, aldehydes C6-C12, anisaldehyde, acetal R, acetophenone, methyl cedrolone, adoxal, galbanum, pineapple ester, ambroxan, pentyl cinnamaldehyde, pentyl cinnamaldehyde dimethyl acetal, amyl valerianate, amyl salicylate, acetyl eugenol, isoamyl acetate, isoamyl salicylate, indole, ionone, isobornyl acetate, ifocyclocitraldehyde, ambroxol, isononyl acetate, isobutylquinoline, γ-undecyl lactone, ethylene brassinate, ethylene dodecanoate, and ethyl vanillin. vanillin), 2-ethylhexanol, aurantiol, 10-oxahexadecyl lactone, 11-oxahexadecyl lactone, 12-oxahexadecyl lactone, oxahexadecene-2-one, eugenol, orivone, oxyphenylone, galacin, caryophyllene, cashmereone, carvone, β-caryophyllene, citronellol, p-cresol methyl ether, geraniol, geraniyl acetate, geraniyl formate, citronellol, koavone, sandalore, San dela, Santalex, cinnamyl alcohol, cinnamaldehyde, cis-jasmone, citral, citral dimethyl acetal, neraldehyde, citronellol, citronellol acetate, citronellol formate, citronellol, sicuraset, cyclapropionate, dimethylbenzyl alcohol, dihydrojasmone, dihydrolinalool, dihydromyrcetol, 2,6-dimethyl-2-heptanol, 2,6-dimethyl-7-octen-2-ol, diphenyloxy (Oxide), hexyljasmone, jasmolactone, jasmofen, cinnamyl acetate, cyclopentadecenone, cyclohexadecenone, cyclopentadecenone, cyclohexadecenone, dimethyl benzyl acetate, tricyclodecenyl acetate, styrax acetate, styrax propionate, cedrol, celestrol, α-dihydrodamascone, β-dihydrodamascone, δ-dihydrodamascone, damascenone, terpineol, terpineol acetate, thymol, tetrahydrolinalool, tetrahydrolinalool acetate, tetrahydrogeraniol, acetic acid-3,7-Dimethyl octyl acetate, turpentine, turpentine, privet aldehyde, nerol acetate, nerol, neobergamate, γ-nonalactone nopylalcohol, nopyl acetate, bacontanol, 2-phenylpropanol (hydrotropic alcohol), α-pinene, β-pinene, hydroxyvanillin, hyacinth dimethyl acetal acetal), butyl butyrate, p-tert-butylcyclohexanol, p-tert-butylcyclohexyl acetate, o-tert-butylcyclohexanol, o-tert-butylcyclohexyl acetate, fructose ester, frankinc, phenylethylphenyl acetate, phenethyl acetate, pentalide, o-tert-butylcyclohexyl acetate (verdox), benzyl acetate, benzyl alcohol, benzyl salicylate, 2-methyl-6-methylene-7-octen-2-ol acetate (bergamyl acetate), benzaldehyde, benzyl formate, methyl dihydrojasmonic acid (hedione), neojasmaldehyde, heliotropin, cis-3-hexenol, cis-3-hexenyl acetate, cis-3-hexenyl salicylate, hexyl cinnamaldehyde, hexyl salicylate, bornyl acetate, borneol, manzanate, mayol, myrcene, citric acid, muguetaldehyde Aldehyde), Muguol, Musk™-11, Musk 781, Musk C14, Muskone, Ketone Musk, Tibetan Musk, Menthol, o-tert-butylcyclohexyl acetate, Methyl anthranilate, Methyleugenol, Menthol, α-methylionone, β-methylionone, γ-methylionone, Isoeugenol methyl ether, 1-hydroxy-3-decanone, Methyl salicylate, 14-methyl-hexadecenolide, 14-methyl-hexadecanolide, Methylnaphthyl ketone, Methylphenylacetate, Di-naphthyl methyl ether, δ-C6-C13 lactone, Calcium oxide Oxide), γ-C6-C13 lactone, raspberry ketone, limonene, privet aldehyde, lilial, linalool, linalool oxide, linalyl acetate, lyral, rhubafuran, rosephenone, rose ether, vanillin, etc.

[0108] It should be noted that the natural and / or synthetic fragrances listed above are dissolved in various solvents as flavor bases to form water-soluble or oil-soluble fragrances.

[0109] As cosmetic ingredients, examples include placental extract, mulberry bark extract, saxifrage extract, perilla extract, white mustard seed extract or its hydrolysate, fermented white mustard seed, Damask rose extract, peony extract or its hydrolysate, lactic acid bacteria fermented rice, lotus seed extract or its hydrolysate, lotus seed ferment, codonopsis extract, coix seed hydrolysate, coix seed ferment, royal jelly ferment, sake lees ferment, anise extract, and Arcangelicia. Flava extract, kiwi extract, chamomile extract, Salicornia zebrina extract, rice leaf extract or its hydrolysate, eggplant (water eggplant, long eggplant, Kamo eggplant, rice eggplant, etc.) extract or its hydrolysate, seaweed extracts such as Euphorbia milii, extracts of marine flowering plants such as Eelgrass, fermented soybean milk, jellyfish water, fermented rice extract, linoleic acid and its derivatives or processed products (e.g., liposome-modified linoleic acid), collagen and its derivatives derived from animals or fish, elastin and its derivatives, glycyrrhizic acid and its derivatives (dipotassium salt, etc.), tertiary cyclic amino acid derivatives, allantoin, arbutin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, Gentian extract, licorice extract, carrot extract, aloe extract, Laminaria angustata extract, Ulva procumbens extract, Rhamnoceae Zizyphus joazeiro extract, unripe peach extract, etc.

[0110] Other possible complementary ingredients include, for example: blood circulation enhancers (e.g., benzyl nicotinate, β-butoxyethyl nicotinate, capsaicin, gingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, nicotinic acid tocopherol, inositol nicotinate, cyclomansyl ester, cinnarizine, tolazoline, acetylcholine, verapamil, styraxetine, γ-oryzanol, etc.); anti-inflammatory agents (e.g., glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, physalisol, zinc oxide, allantoin, etc.); and activators. (e.g., royal jelly, photosensitizers, cholesterol derivatives, etc.); anti-seborrheic agents (e.g., sulfur, dimethylthiazide, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, linoleic acid, etc.); various other extracts (e.g., Phellodendron bark, Coptis root, purple root, peony root, Japanese swert, birch, sage, loquat, carrot, aloe vera, mallow, iris, grape, coix seed, loofah, lily, saffron, chuanxiong rhizome, ginger, forsythia, gentian flower, garlic, chili, tangerine peel, angelica, seaweed, etc.); etc.

[0111] Example

[0112] The present invention will now be specifically described through examples. However, the present invention is not limited to these examples, and variations may be made without departing from the scope of the invention. It should be noted that in the following examples, unless otherwise specified, % represents a quality standard.

[0113] Creamy cosmetics (I)

[0114] The following examples show compounds of general formula (1) that have antibacterial and preservative properties.

[0115] <Compounds represented by general formula (1)>

[0116] Compound (1)-1: Pentylene glycol (in general formula (1), R 1 (A compound of ethyl group)

[0117] Compound (1)-2: Cyclohexylglycerol ether (in general formula (1), R 1 (For compounds with the group represented by general formula (2) and n = 0)

[0118] The following shows the antibacterial preservatives commonly used in cosmetics in the comparative examples.

[0119] <Antibacterial Preservatives>

[0120] Phenoxyethanol

[0121] n-Hexylglycerol ether

[0122] Octyl ethylene glycol

[0123] Ethylhexylglycerin

[0124] [Storage stability test of cosmetics]

[0125] The ingredients of the cream cosmetic (I) used in the examples and comparative examples are shown in Table 1.

[0126] [Table 1]

[0127]

[0128] In the cream-like cosmetics (I) listed in Table 1, PEG-40 stearic acid and glyceryl monostearate were used as surfactants, betaine alcohol (a higher alcohol), dimeric pentaerythritol hexa(hydroxystearic acid / stearic acid / rosinic acid) ester and liquid paraffin were used as oil phase components, and 1,3-butanediol, glycerin, xanthan gum and water were used as aqueous phase components.

[0129] After a cosmetic is manufactured using ingredients other than antibacterial and preservative components, an antibacterial and preservative component is subsequently added, thereby obtaining an oil-in-water cream cosmetic (I). More specifically, a surfactant and an oil phase component are dissolved by heating, an aqueous phase component is dissolved by heating in another system, and the aqueous phase component is added to the oil phase component for phase inversion emulsification, thereby obtaining a cosmetic. Then, the compound shown in the general formula (1) and / or the antibacterial and preservative described above are subsequently added, thereby preparing the following cream cosmetics (I)-1 to (I)-20 (refer to Table 2). It should be noted that for the cream cosmetics (I)-13 to (I)-20 that use the compound shown in general formula (1) and the antibacterial and preservative, 0.5% by mass of each is used, totaling 1.0% by mass.

[0130] [Table 2]

[0131]

[0132] Next, a storage stability test was conducted using the aforementioned cream-like cosmetics. The obtained cream-like cosmetics (I)-1 to (I)-20 were placed in polyethylene containers with a diameter of 4 cm and a height of 6 cm, and a storage stability test was conducted at 50°C for one month. As an evaluation method, the following criteria were used, and the results were visually verified. The results are shown in Table 3.

[0133] [Evaluation Method]

[0134]

[0135]

[0136] [Table 3]

[0137]

[0138] As a result, in Examples 1-4 where the method of the present invention was applied, very good storage stability was observed under the assumed high temperature environment of summer. Furthermore, the cream-like cosmetics with poor storage stability in Comparative Examples 1, 3, 5, and 7 also showed a significant improvement in storage stability when used in combination with the compound shown in general formula (1) (Examples 5-12). That is, a cosmetic with good storage stability was obtained that combines the antibacterial and preservative effects of the compound shown in general formula (1) with the antibacterial and preservative effects of phenoxyethanol, n-hexylglycerol ether, octyl glycol, and ethylhexylglycerin.

[0139] Creamy cosmetics (II)

[0140] The following examples show compounds of general formula (1) that have antibacterial and preservative properties.

[0141] <Compounds represented by general formula (1)>

[0142] Compound (1)-1: Pentylene glycol (in general formula (1), R 1 (A compound of ethyl group)

[0143] Compound (1)-2: Cyclohexylglycerol ether (in general formula (1), R 1 (For compounds with the group represented by general formula (2) and n = 0)

[0144] The following shows the antimicrobial preservatives used in the comparative examples.

[0145] Antibacterial and preservative agents

[0146] Phenoxyethanol

[0147] n-Hexylglycerol ether

[0148] Octyl ethylene glycol

[0149] Ethylhexylglycerin

[0150] [Storage stability test of cosmetics]

[0151] The ingredients of the cream cosmetic (II) used in the examples and comparative examples are shown in Table 4.

[0152] [Table 4]

[0153] Element Component amount (mass%) Polyglycerol-6 polyricinoleate 1.50 Polyglycerol-10 stearate 0.50 squalane 8.00 Vaseline 4.00 Triisooctanoic acid glyceride 4.00 Diphenylsiloxyphenyl polytrimethylsiloxane 5.00 glycerin 5.00 Sorbitol 10.00 salt 2.00 Purified water Remaining Antibacterial and preservative ingredients (Y) total 100.00

[0154] In the cream-like cosmetic (II) described in Table 4, polyglycerol-6 polyricinoleate and polyglycerol-10 stearate were used as surfactants, squalane, petrolatum, triethylhexanoin and diphenylsiloxyphenyl polytrimethylsiloxane were used as oil phase components, and glycerol, sorbitol, salt and water were used as aqueous phase components.

[0155] After a cosmetic is manufactured using ingredients other than antibacterial and preservative components, an antibacterial and preservative component is subsequently added, thereby obtaining a water-in-oil cream cosmetic (II). More specifically, a surfactant and an oil phase component are dissolved by heating, an aqueous phase component is dissolved by heating in another system, and the aqueous phase component is added to the oil phase component for reverse emulsification, thereby obtaining a cosmetic. Then, a compound represented by the general formula (1) described above and / or an antibacterial and preservative are subsequently added, thereby preparing the following cream cosmetics (II)-1 to (II)-8 (see Table 5).

[0156] [Table 5]

[0157]

[0158] Next, a storage stability test was conducted using the aforementioned cream-like cosmetics. The obtained cream-like cosmetics (II)-1 to (II)-8 were placed in polyethylene containers with a diameter of 4 cm and a height of 6 cm, and a storage stability test was conducted at 50°C for one month. As an evaluation method, the following criteria were used, and the results were visually verified. The results are shown in Table 6.

[0159] [Evaluation Method]

[0160]

[0161]

[0162] [Table 6]

[0163]

[0164] As a result, very good preservation stability was observed in Examples 13-16 where the method of the present invention was applied. Thus, it is shown that by applying the present invention, cosmetics exhibiting high preservation stability can be obtained even under high-temperature environments such as summer.

[0165] Industrial availability

[0166] In the method of the present invention, by combining a compound of general formula (1) that has antibacterial and preservative effects and is less irritating to the skin, the preservation stability of cosmetics can be well maintained. Furthermore, the method of the present invention is a highly useful invention, and even when it is necessary to use commonly used antibacterial preservatives, the deterioration of preservation stability caused by commonly used antibacterial preservatives can be suppressed by applying the method of the present invention.

Claims

1. A method for preventing the separation and precipitation of aqueous components in a cream-like cosmetic at 40–60°C, comprising: In accordance with the steps of producing a compound represented by the following general formula (1), the cosmetic contains one or more antibacterial preservatives selected from the group consisting of n-hexylglycerol ether, octyl glycol, and ethylhexylglycerin. In the formula, R 1 The group or ethyl group represented by general formula (2) In the formula, R 2 This indicates an alkylene group with 1 to 3 carbon atoms, where n represents 0.

2. The method according to claim 1, wherein, The compound represented by the general formula (1) is combined in an amount of 0.05 to 5% by mass relative to the total amount of cosmetics.

3. The method according to claim 1 or 2, wherein, The cosmetic contains higher alcohols.

4. The method according to claim 1 or 2, wherein, The cosmetic contains surfactants.

5. The use of a compound represented by the following general formula (1) in preventing the separation and precipitation of aqueous components in a cream-like cosmetic at 40–60°C, said cosmetic containing one or more antibacterial preservatives selected from the group consisting of n-hexylglycerol ether, octyl glycol, and ethylhexylglycerin. In the formula, R 1 The group or ethyl group represented by general formula (2) In the formula, R 2 This indicates an alkylene group with 1 to 3 carbon atoms, where n represents 0.

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