PSMA特异性的双环肽配体

By designing PSMA-specific bicyclic peptide ligands to covalently bind to a molecular scaffold, forming at least two polypeptide rings, the problem of insufficient polypeptide binding force and selectivity in existing technologies is solved, achieving high affinity binding and stability to PSMA, and making it suitable for therapeutic applications via various routes of administration.

CN113507960BActive Publication Date: 2026-07-17BICYCLERD LTD
View PDF 6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BICYCLERD LTD
Filing Date
2019-12-13
Publication Date
2026-07-17

Smart Images

  • Figure BDA0003160534890000111
    Figure BDA0003160534890000111
  • Figure BDA0003160534890000112
    Figure BDA0003160534890000112
  • Figure BDA0003160534890000161
    Figure BDA0003160534890000161
Patent Text Reader

Abstract

本发明涉及多肽，其与分子支架共价结合，使得在支架的连接点之间对向存在两个或更多个肽环。特别地，本发明描述了作为前列腺特异性膜抗原(PSMA)的高亲和力结合物的肽。本发明还包括包含与一个或多个效应子和 / 或官能团偶联的所述肽的药物偶联物，包含所述肽配体和药物偶联物的药物组合物，以及所述肽配体和药物偶联物在预防、抑制或治疗PSMA介导的疾病或疾患中的用途。
Need to check novelty before this filing date? Find Prior Art